Digital Commons Network^™

Chloroviruses, James L. Van Etten, Irina V. Agarkova, David D. Dunigan

Nebraska Center for Virology: Faculty Publications

Chloroviruses are large dsDNA, plaque-forming viruses that infect certain chlorella-like green algae; the algae are normally mutualistic endosymbionts of protists and metazoans and are often referred to as zoochlorellae. The viruses are ubiquitous in inland aqueous environments throughout the world and occasionally single types reach titers of thousands of plaque-forming units per ml of native water. The viruses are icosahedral in shape with a spike structure located at one of the vertices. They contain an internal membrane that is required for infectivity. The viral genomes are 290 to 370 kb in size, which encode up to 16 tRNAs and 330 …

A Microfluidic Paper-Based Analytical Device For Early Diagnosis And Prognosis Of Acute Myocardial Infarction, Lim Wei Yin

Student Works (2020-2029)

Acute myocardial infarction (AMI), also termed as heart attack, is often clinically screened by blood test through the measurement of cardiac biomarkers (i.e., troponin (T or I), creatine kinase (CK−MB) and myoglobin) and electrocardiography (ECG) changes which are presented to the hospital. However, the early diagnosis of AMI is challenging because the detection of biomarkers such as troponin (T or I) and CK−MB are only reliable at the intermediate and later stages (> 6 hours after chest pain onset), during myocardial injury and myocardial infarction. On the other hand, myoglobin often been used as early biomarker which is detectable within …

Eye Spy, Robbin Ray

UNH Today Archive

No abstract provided.

State V. Nasker Respondent's Brief Dckt. 46728

Not Reported

No abstract provided.

State V. Moore Appellant's Brief Dckt. 46965

Not Reported

No abstract provided.

Interpretable Deep Neural Network For Cancer Survival Analysis By Integrating Genomic And Clinical Data, Jie Hao, Youngsoon Kim, Tejaswini Mallavarapu, Jung Hun Oh, Mingon Kang

Computer Science Faculty Research

Background: Understanding the complex biological mechanisms of cancer patient survival using genomic and clinical data is vital, not only to develop new treatments for patients, but also to improve survival prediction. However, highly nonlinear and high-dimension, low-sample size (HDLSS) data cause computational challenges to applying conventional survival analysis. Results: We propose a novel biologically interpretable pathway-based sparse deep neural network, named Cox-PASNet, which integrates high-dimensional gene expression data and clinical data on a simple neural network architecture for survival analysis. Cox-PASNet is biologically interpretable where nodes in the neural network correspond to biological genes and pathways, while capturing the nonlinear …

Robust Cullin-Ring Ligase Function Is Established By A Multiplicity Of Poly-Ubiquitylation Pathways, Spencer Hill, Kurt Reichermeier, Daniel C. Scott, Lorena Samentar, Jasmin Coulombe-Huntington, Luisa Izzi, Xiaojing Tang, Rebeca Ibarra, Thierry Bertomeu, Annie Moridian, Michael J. Sweredoski, Nora Caberoy, Brenda A. Schulman, Frank Sicheri, Mike Tyers, Gary Kleiger

Life Sciences Faculty Research

The cullin-RING ligases (CRLs) form the major family of E3 ubiquitin ligases. The prototypic CRLs in yeast, called SCF enzymes, employ a single E2 enzyme, Cdc34, to build poly-ubiquitin chains required for degradation. In contrast, six different human E2 and E3 enzyme activities, including Cdc34 orthologs UBE2R1 and UBE2R2, appear to mediate SCF-catalyzed substrate polyubiquitylation in vitro. The combinatorial interplay of these enzymes raises questions about genetic buffering of SCFs in human cells and challenges the dogma that E3s alone determine substrate specificity. To enable the quantitative comparisons of SCF-dependent ubiquitylation reactions with physiological enzyme concentrations, mass spectrometry was employed …

Longitudinal Change In Regional Brain Volumes With Exposure To Repetitive Head Impacts, Charles Bernick, Guogen Shan, Henrik Zetterberg, Sarah Banks, Virendra R. Mishra, Lynn Bekris, James B. Leverenz, Kaj Blennow

Environmental & Global Health Faculty Research

Objective This study tests the hypothesis that certain MRI-based regional brain volumes will show reductions over time in a cohort exposed to repetitive head impacts (RHI). Methods Participants were drawn from the Professional Fighters Brain Health Study, a longitudinal observational study of professional fighters and controls. Participants underwent annual 3T brain MRI, computerized cognitive testing, and blood sampling for determination of neurofilament light (NfL) and tau levels. Yearly change in regional brain volume was calculated for several predetermined cortical and subcortical brain volumes and the relationship with NfL and tau levels determined. Results A total of 204 participants who had …

Multicenter Clinical Evaluation Of Etest Meropenem-Vaborbactam (Biomérieux) For Susceptibility Testing Of Enterobacterales (Enterobacteriaceae) And Pseudomonas Aeruginosa, Sophonie Jean, Sheri Garrett, Claire Anglade, Laurence Bridon, Leanne Davies, Omai B Garner, Jennifer Richards, Meghan Wallace, Mandy Wootton, Carey-Ann D. Burnham

Open Access Publications

Meropenem-vaborbactam (MEV) is a novel carbapenem-beta-lactamase inhibitor combination antibiotic approved by the U.S. Food and Drug Administration (FDA) for treatment of complicated urinary tract infections, including pyelonephritis, in adults. In this study, we evaluated the performance of Etest MEV (bioMérieux, Marcy l'Etoile, France) compared to that of broth microdilution for 629

A Qualitative Study Of Older Adults' Perspectives On Initiating Exercise And Mindfulness Practice, Diana C Parra, Julie Loebach Wetherell, Alexandria Van Zandt, Ross C Brownson, Janardan Abhishek, Eric J Lenze

Open Access Publications

BACKGROUND: Mindfulness practice and exercise are ways by which older adults can improve and maintain their physical, emotional and cognitive health.

METHODS: This single-site qualitative study gathered insights of older adults' perceptions about initiating and maintaining mindfulness and exercise practices. We carried out focus groups with 41 adults aged 65-85 who had recently initiated Mindfulness Based Stress Reduction (MBSR), structured exercise, or their combination as part of participation in a clinical trial. We used a semi-structured interview to ask them open-ended questions regarding the benefits, barriers and facilitators of participating in mindfulness and/or exercise interventions. The interview also included questions …

Community-Based Responses To Negative Health Impacts Of Sexual Humanitarian Anti-Trafficking Policies And The Criminalization Of Sex Work And Migration In The Us, Heidi Hoefinger, Jennifer Musto, P.G. Macioti, Anne E. Fehrenbacher, Nicola Mai, Calum Bennachie, Calogero Giametta

Publications and Research

System-involvement resulting from anti-trafficking interventions and the criminalization of sex work and migration results in negative health impacts on sex workers, migrants, and people with trafficking experiences. Due to their stigmatized status, sex workers and people with trafficking experiences often struggle to access affordable, unbiased, and supportive health care. This paper will use thematic analysis of qualitative data from in-depth interviews and ethnographic fieldwork with 50 migrant sex workers and trafficked persons, as well as 20 key informants from legal and social services, in New York and Los Angeles. It will highlight the work of trans-specific and sex worker-led initiatives …

Safety Of Paclitaxel-Coated Balloon Angioplasty For Femoropopliteal Peripheral Artery Disease, Constantino Pena

All Publications

No abstract provided.

Parenting Paused: Pathological Video Game Use And Parenting Outcomes, Laura Stockdale, Sarah M. Coyne

Faculty Publications

For most people, playing video games is a normal recreational activity, with little disruption to gamers’ emotional, social, or physical health and well-being. However, for a small percentage of gamers, video gaming can become pathological (Fam, 2018). Substantial research has examined pathological gaming in teens and young adults (Cheng, Cheung, & Wang, 2018; Choo, Gentile, Sim, Khoo, & Liau, 2010), yet pathological gaming in adults (c.f.Holgren, 2017), especially in the context of parenthood, has been relatively ignored. The current study sought to address this limitation by studying associations between pathological gaming characteristics and parenting outcomes in a sample of men …

Blockchain Based Access Control For Enterprise Blockchain Applications, Lei Xu, Isaac Markus, Subhod I, Nikhil Nayab

Computer Science Faculty Publications

Access control is one of the fundamental security mechanisms of IT systems. Most existing access control schemes rely on a centralized party to manage and enforce access control policies. As blockchain technologies, especially permissioned networks, find more applicability beyond cryptocurrencies in enterprise solutions, it is expected that the security requirements will increase. Therefore, it is necessary to develop an access control system that works in a decentralized environment without compromising the unique features of a blockchain. A straightforward method to support access control is to deploy a firewall in front of the enterprise blockchain application. However, this approach does not …

Characterization And Domestication Of Wild Edible Mushrooms From Selected Indigenous Forests In Burundi, Vincent Nteziryayo, Donatha D. Tibuhwa, Prosper Kiyuku, Tatien Masharabu

Tanzania Journal of Science

In Burundi, minimum work has been done to comprehensively identify and commercialize high yielding local mushrooms. The previous studies carried out on mushroom cultivation have focused on exotic strains. This is the first study undertaken on domestication of wild edible mushrooms from Burundi indigenous forests. Nine samples were collected from four protected areas and characterized using phenotypic and molecular markers. Germoplasm isolation through tissue culture techniques, spawn production and cultivation studies were also undertaken. Mushroom samples were identified as Pleurotus citrinopileatus, Lentinus squarrosulus, Hypholoma fasciculare, Laetiporus sulfureus, Macrolepiota dolichaula, Trametes polyzona, Amanita zambiana, Lactarius delicious and Amanita verna. Spawn production …

Radioactivity Assessment Of 40k, 238u And 232th In Surface Soil Samples Of Igbokoda, Southwest Of Nigeria, Olusegun Sowole, Kolawole A. Egunjobi

Tanzania Journal of Science

Natural radionuclides are found in soil and are capable of disintegrating leading to the release of ionizing radiations that can have harmful effects on individuals exposed to them most especially when exceeding the recommended global limits of radiological parameters. Assessment of activity  concentrations of 40K, 238U and 232Th in surface soil samples from different locations  at Igbokoda where crude oil exploration was taking place, at Ondo State in Nigeria, had been determined by gamma spectrometry using NaI (TI) detector coupled with a pre-amplifier base connected to a multiple channel analyzer (MCA) which was used to calculate the radiological indicators. 10 …

Assessment Of Tree Species Richness, Diversity, Population Structure And Natural Regeneration In Nongeni Forest Reserve In Morogoro Region, Tanzania, David Sylvester Kacholi

Tanzania Journal of Science

This study examined tree species richness, diversity, population structure and regeneration in Nongeni forest reserve, Morogoro, Tanzania. The study deployed plot sampling technique whereby a total of 20 plots of 0.05 ha each were randomly established in the forest. All species and individuals encountered in each plot were counted, identified and DBH measured. A total of 751 individuals/ha representing 24 species belonging to 11 families were recorded. Family Fabaceae was dominant with 9 species. The Shannon-Wiener, Margalef, Simpson’s and Pielou J index were calculated as 2.667, 3.474, 10.58 and 0.839, respectively. The Diplorhynchus condylocarpon (52.18) was the dominant species in …

Target-To-Target Interaction In Through-The-Wall Radars Under Path Loss Compensated Multipath Exploitation-Based Signal Model For Sparse Image Reconstruction, Emmanuel K. Kokumo, Baraka Maiseli, Abdi T. Abdalla

Tanzania Journal of Science

Multipath caused by reflections from interior walls of buildings has been a long-standing challenge that affects through-the-wall radar imaging. Multipath creates ghost images that introduce confusion when detecting desired targets. Traditionally, multipath exploitation techniques under the compressive sensing framework have widely been applied to address the challenge. However, the multipath component emanating from target-to-target interactions has not been considered–a consequence that may, under multiple target scenarios, lead to incorrect image interpretation. Besides, far targets experience more attenuation due to free space path loss, hence resulting into target undetectability. This study proposes a signal model, based on multipath exploitation techniques, by …

Preliminary Palynology Of The Karoo Equivalent Tanga Beds, Coastal Tanzania: Insights On Preservation, Age And Depositional Environments, Stephen Peter Magohe

Tanzania Journal of Science

The major challenge to the current understanding of the stratigraphy of the Tanga Basin is scarcity of biostratigraphy age-control data. A number of palynomorphs retrieved from core samples of the Tanga Beds and analysed for palynology are here presented. These include bisaccate pollen grains belonging to the Alisporites-Falcisporites complex, making about 55% average of the total assemblage. The rest of the assemblage comprises other palynomorphs (pollen and spores) and phytoclasts. The miospores documented from the studied samples have poor to fairly good preservation; the organic residues (non-pollen palynomorphs) are excellently preserved. Based on palynologic evidences, and the presence of fossil …

Antimicrobial Activities Of Endophytic Fungi Secondary Metabolites From Moringa Oleifera (Lam), Zuhura N. Mwanga, Esther F. Mvungi, Donatha D Tibuhwa

Tanzania Journal of Science

This study presents the antimicrobial activities of secondary metabolites of endophytic fungi isolated from a medicinal plant Moringa oleifera growing at the University of Dar es Salaam, Tanzania. Two endophytic fungi were identified, Nigrospora sp. from leaves, and Fusarium sp. from roots and seeds. The disc method was used in testing the antimicrobial activities of the crude extracts of endophytic fungi secondary metabolites against four human pathogens, namely, Bacillus substilis, Staphylococcus aureus, Escherichia coli, and Candida albicans. The results revealed that the crude extracts of endophytes secondary metabolites from leaves showed strong antimicrobial activities against two Gram positive bacteria and …

Effects Of Seasons And Zonation On Biochemical Contents Of Two Seagrass Species Along Dar Es Salaam Coast, Tanzania, Wamwi M. Mbaga, Esther F. Mvungi

Tanzania Journal of Science

Accumulation and allocation of biochemicals in plants are affected by various factors. The influence of seasons and vertical zonation on biochemical contents of seagrasses Cymodocea rotundata and Thalassia hemprichii from Mjimwema seagrass meadow along the coast of Dar es Salaam were assessed. Samples were collected in 2016 during wet/rainy (April–May) and dry (June–July) seasons. Concentrations of crude protein, soluble carbohydrates, phosphorus, lipid, and proline were determined using standard methods. Significant higher levels of phosphorus, lipid, protein and proline were observed during the dry season than in wet season (p < 0.05). Likewise, seagrass population occurring at the shore zone expressed higher levels of biochemical contents than those found at the subtidal zones. The highest concentration of protein was recorded in Thalassia hemprichii (5.8 mg/g dw)), while those of lipid and carbohydrates (27.1 and 53.1 mg/g dw, respectively) were recorded in Cymodocea rotundata. The two species studied did not vary significantly in their biochemical concentrations in both seasons. Generally it was observed that the concentrations of studied biochemicals were up-regulated during the dry season and varied depending on the locations where the seagrass grow. Thus, both season and zonation played roles in biochemical accumulation in the seagrasses understudy, however not interactively.

Land Cover Change Detection In The Urban Catchments Of Dar Es Salaam, Tanzania Using Remote Sensing And Gis Techniques, Philip Mzava, Joel Nobert, Patrick Valimba

Tanzania Journal of Science

In this study, the Maximum Likelihood (ML) classification, Normalized Difference Vegetation Index (NDVI) and Artificial Neural Network (ANN) methods were applied to three (3) Landsat images collected over time (1979, 1998 and 2014), that contained historical land cover features for the urban catchments of Dar es Salaam. Five major land cover classes were identified, mapped, and the land cover changes investigated. The major land cover changes observed from post-classification comparisons of the classified images are: the forest land losing 17.09% of its area in the period 1979-1998 to other land covers, mainly turning to grassland, and from 1998 to 2014, …

The Need Of A Structured Tilapia Breeding Program In Tanzania To Enhance Aquaculture Production: A Review, Redempta A. Kajungiro, Levinus L. Mapenzi, Christer S. Nyinondi, Anna Norman Haldén, Aviti J. Mmochi, Mwita Chacha, Matern S.P. Mtolera, Hieromin A. Lamtane, Dirk Jan De Koning

Tanzania Journal of Science

Breeding programs are crucial for boosting productivity and increase sustainability of aquaculture. Over years, Tanzania has witnessed fluctuation in its capture fisheries production from 320,900 to 375, 535 and back to 362,595 metric tonnes in the years 2000, 2005 and 2016, respectively (URT 2016). The declining trend in fish production has made fish supply in the country unstable and conversely, increased the demand for fishes to about 730,000 metric tonnes in 2017. However, the local aquaculture production has not increased accordingly. Tanzania is importing fish mainly from Asia to meet its increased demand. In 2017, a total of 2,055,721 kg …

The Afghan Peace Talks, China, And The Afghan Elections, Grant M. Farr

Sociology Faculty Publications and Presentations

After more than a year of negotiations it appeared in the fall of 2019 that an agreement had been reached between the United States and the Afghan Taliban. Yet before the agreement could be formally signed, the United States backed away from the agreement citing the death of an American serviceman as a result of a Taliban bomb. The negotiations are now officially on hold, although Zalmay Khalilzad, the United States Special Representative, continues to talk to the Taliban through other channels. The failure, at least so far, of an agreement between the United States and Taliban has numerous consequences, …

How Save Aquinas's "Intellectus Essentiae Arguement" For The Real Distinction Between Essence And Esse?, David Twetten

Philosophy Faculty Research and Publications

Aquinas’ so-called “Intellectus essentiae Argument” for the distinction between being and essence is notoriously suspect, including among defenders of Aquinas’ distinction. For the paper in this volume, I take as my starting point the recent defense of the argument by Fr. Lawrence Dewan, O.P. Fr. Dewan’s project is unsuccessful. Pointing out some shortcomings in his readings allows me to take up his call to highlight the “formal” or “quidditative side” of Aquinas’ metaphysics, in this case in regards to the proofs of the “real distinction.” Accordingly, the second half of this paper sets forth a way in which the …

Remediating Professionalism Lapses In Medical Students And Doctors: A Systematic Review, Nicola Brennan, Tristan Price, Julian Archer, Joe Brett, Nicola Brennan

Peninsula Medical School

No abstract provided.

The Impact Of Neuro Linguistic Programming On Employees’ Performance:An Experimental Study In Al-Hussein Bin Abdullah Ii Industrial Estate-Jordan, Asaad Hameed O. Al-Ali, Basma Salem Shamaileh

Al-Balqa Journal for Research and Studies البلقاء للبحوث والدراسات

This study investigates the impact of Neuro Linguistic Programming (NLP) on employees performance, using the experimental approach in Al-Hussein Bin Abdullah II Industrial Estates. The focus is on behavioral-based performance through four dimensions: self-efficacy, communication skills, problem-solving skills and the employees productivity. The sample consists of (44) employees from different departments distributed randomly into two groups. The first group (experimental) has attended the NLP training program introduced by a qualified specialist in this field, and the second group represents the control group. Leven test is used to verify variance homogeneity between groups. Pre-test and post-test are adopted by distributing questionnaires …

Does Sovereign Rating Announcement Have Symmetrical Effect On Stock Market Returns?Case Study: Amman Stock Exchange (Ase), Ohoud Khasawneh

Al-Balqa Journal for Research and Studies البلقاء للبحوث والدراسات

This paper aims to investigate whether the effect of Sovereign rating change is symmetrical or not. As well as are the effects are same of Sovereign rating upgrades and downgrades announcement on stock return in the Amman Stock Exchange (ASE). In this study, the event study methodology was applied to analyse the effect of ten announcements (included four upgrades and six downgrades) from the rating agency S&P500 and Moody’s over the period 2003-2013. By using the daily closing price of Amman free float market index as a proxy for return and an event period which are set as [-10, +10] …

Childhood Disability: Challenges And Theory-Informed Child Life Interventions In The Healthcare Setting, Fatema-Zahra Jaffer

Graduate Student Independent Studies

Children with intellectual, sensory, physical, and/or speech disabilities encounter a proliferation of challenges in the healthcare environment. Such challenges are exacerbated by insufficient knowledge in doctors, nurses, child life specialists, and other healthcare providers in bias-free and specialized healthcare delivery. To remedy this, pertinent methods informed by theoretical perspectives of atypical development that ameliorate stress and augment coping in children with disabilities are warranted. Therefore, the purpose of this independent study is to provide a synthesis of the literature that chronicles this topic. Multifarious child life interventions that are premised on contemporary developmental frameworks of childhood disability will be presented. …

Features Of The Use Of Information And Communication Technologies In The Educational Process, Doniyor Baxodirovich Аbduraximov, Muzrob Doniyor OʼGʼLi Baxodirov

Bulletin of Gulistan State University

The article describes the features of the use of information and communication technologies in the educational process. As a result of the introduction of information and communication technologies in various fields, the concept of informatization of an informed society arises. Informatization of society means the process of using information as the wealth of society, which ensures economic development, scientific and technological progress of the country, accelerating the process of democratization and intellectualization of society. Public awareness is an objective process related to the increasing role of intellectual activity in all spheres of human life. Informatization of society serves to improve …