Digital Commons Network^™

The Anaplasma Phagocytophilum Adhesin Asp14 Directs Pdi-Mediated Disulfide Reduction To Promote Infection, Ryan S. Green

Theses and Dissertations

Obligate intracellular pathogens must invade host cells to survive and pose a global health risk. As such, internalization is a critical life stage and represents an excellent therapeutic target. Oxidoreductase exploitation is a thematic invasion strategy among obligate intracellular pathogens. Delineating the mechanisms and proteins mediating this exploitation could identify novel therapeutic targets for many important pathogens. Anaplasma phagocytophilum infects neutrophils by an incompletely defined mechanism, resulting in the emerging potentially fatal disease, human granulocytic anaplasmosis. The bacterial adhesin, Asp14, contributes to invasion by virtue of its C-terminus engaging an unknown receptor. Yeast two-hybrid analysis identified protein disulfide isomerase (PDI) …

Pharmacologic Profiling Of Novel Compounds Via Fluorometric Analyses Of Monoamine Transporter Responses, Ashkhan Hojati

Theses and Dissertations

In humans and other organisms, monoaminergic systems are crucial in neuronal function and behavior. The monoamine transporters (MATs), which can be found on the presynaptic plasma membrane of neurons in the central nervous system (CNS), are crucial in the regulation of neurotransmitter concentration in the synaptic cleft. As the duration and concentration of neurotransmitters in the cleft affect further downstream signaling responses, these proteins are important targets for both understanding neuronal physiology and compounds of interest. Multiple theories exist proponing the contribution of MATs to a variety of mental and neurological disorders, including depression. This theory establishes that depression is …

Factors Influencing Parental Care And Home Range Size Of A Monomorphic Species, The Red-Headed Woodpecker (Melanerpes Erythrocephalus), L. Abigail Walter

Theses and Dissertations

Parental care in animals can be costly and is shared between both parents in many bird species. Not surprisingly, most studies of how parental care is shared between the sexes are in sexually dimorphic species, and much less in known about sexually monomorphic species where sex cannot be determined in the field. This has prevented a full understanding of parental care behaviors – which are intrinsically linked to fitness – in species such as the Red-headed Woodpecker (Melanerpes erythrocephalus) that is experiencing population declines throughout much of its range. In this study we assessed whether Redheaded Woodpecker brooding time, nestling …

The Role Of Psychosocial And Health Behavioral Factors In Pregnancy Induced Hypertension, Sylvia Sreeparna Rozario

Theses and Dissertations

Background: Pregnancy induced hypertension (PIH) is the leading cause of maternal mortality and a major contributor to preterm birth and neonatal mortality. Literature suggests that several modifiable psychosocial and health behavioral factors may play significant roles in the development of PIH. However, interrelationships among these factors and their collective impact on PIH are not well understood.

Objectives: This study aims to: 1) Examine the relationship between pre-pregnancy physical activity and risk of PIH, 2) Determine the association between prepregnancy depression and PIH and the role of race/ethnicity in this association, 3) Evaluate the association between intimate partner violence (IPV) in …

Incidence And Predictor Variables Of Pressure Injuries In Patients Undergoing Ventricular Assist Device And Total Artificial Heart Surgeries: An Eight-Year Retrospective Review, Christopher T. Brindle

Theses and Dissertations

BACKGROUND

Cardiac surgery patients have some of the highest reported incidence and prevalence of pressure injuries (PI). A growing subset of cardiac surgery include patients with end-stage heart failure who undergo ventricular assist device (VAD) or total artificial heart (TAH) surgery. The risk of PI and their natural history of development in this population are unknown and the specific risk factors for PI development remain unexplored.

OBJECTIVES

To perform a systematic review of the literature to identify the incidence and risk factors of PI development in patients undergoing VAD-TAH surgery and thereby inform study design and variables in an eight-year …

Chemical Characterization Of Pseudognaphalium Obtusifolium By Gas Chromatography - Mass Spectrometry (Gc-Ms) To Assess Potential Therapeutic Phytochemicals And Toxicological Concerns Using Simulated Use Conditions, Regina Ballentine

Theses and Dissertations

Chemical Characterization of Pseudognaphalium obtusifolium by Gas Chromatography – Mass Spectrometry (GC-MS) to Assess Potential Therapeutic Phytochemicals and Toxicological Concerns Using Simulated Use Conditions

By Regina Ballentine

Virginia Commonwealth University, 2019

Director: Sarah C. Rutan, Professor, Department of Chemistry

Currently, there is an increasing demand for natural therapies and herbal products to treat various ailments. It is generally believed that natural therapies have fewer side-effects than traditional western medicine; however, they are often used in different strengths and formulations without consistency of the levels of target compounds or knowledge about toxicity. Due to this growing trend, a comprehensive chemical evaluation …

Spatial And Temporal Distributions Of Larval Clupeid Fishes In A Tidal Freshwater Marsh Complex, Philip Reid Anderson

Theses and Dissertations

Tidal freshwater wetlands provide valuable ecosystem services such as nutrient cycling, coastal flood control, and reproductive habitat for early life stages of economically and ecologically important fishes. The nutrient rich environments that tidal freshwater wetlands occur in support high levels of primary productivity of phytoplankton and vegetation that provide essential reproductive habitat for anadromous clupeid fishes (Alosa spp., Brevoortia tyrannus) in Chesapeake Bay tributaries. Seasonal retention of clupeid eggs and larvae within tidal freshwater habitats may enhance early growth, survival, and year class strength. The primary goal of the present study was to characterize the relative importance of …

Glial Cell Mechanisms Regulate Alcohol Sedation In Drosophila Melanogaster, Kristen M. Lee

Theses and Dissertations

Approximately 16 million people in America are diagnosed with Alcohol Use Disorder (AUD) but no efficacious medical treatments exist. Alcohol-related behaviors can be studied in model organisms, and changes in these behaviors can be correlated with either (i) a risk for alcohol dependence or (ii) a symptom/feature of AUD itself. Although AUD is a disease of the central nervous system, a majority of research has focused on the neuronal underpinnings, leaving glial contributions largely undescribed. We used Drosophila melanogaster (fruit fly) to identify genes whose expression in glia regulates alcohol sedation. Mammals and Drosophila have conserved behavioral responses to alcohol …

Research On The Law Of Garlic Price Based On Big Data, Feng Guo, Pingzeng Liu, Chao Zhang, Weijie Chen, Wei Han, Wanming Ren, Yong Zheng, Jianrui Ding

Computer Science Student Research

In view of the frequent fluctuation of garlic price under the market economy and the current situation of garlic price, the fluctuation of garlic price in the circulation link of garlic industry chain is analyzed, and the application mode of multidisciplinary in the agricultural industry is discussed. On the basis of the big data platform of garlic industry chain, this paper constructs a Garch model to analyze the fluctuation law of garlic price in the circulation link and provides the garlic industry service from the angle of price fluctuation combined with the economic analysis. The research shows that the average …

Perspectives Winter/Spring 2019, Nova Southeastern University

Perspectives

Dr. Pallavi Patel College of Health Care Sciences

Kids Count: The State Of The Child In Tennessee [2019], Policy And Issue Guide, Tennessee Commission On Children And Youth

Kids Count/State of the Child in Tennessee Reports

This report provides an overview of information on healthy infants, children and teens; child/teen well-being; education; economic security; and demographics.

Adapting An Elementary School Nutrition Context Assessment For High School Settings And Students, Deborah H. John, Beret Halverson, Tia H. Ho

Urban Studies and Planning Faculty Publications and Presentations

The school nutrition context is comprised of supportive environmental features, programs, policies, and social relationships that shape students’ healthy dietary choices and patterns. When engaging students as change agents, advocates, and partners in making healthy nutrition choices easier, environmental assessment tools developed for adults may be too complex or inappropriately tailored for youth. Adolescents need practical, user-tailored tools that reliably measure the food and beverage environments they encounter in school to inform youth-led changes to the school nutrition context. To meet this need, an evidence-based school environmental assessment was adapted for use in high schools by students as evaluators. Cooperative …

Scandal In The Us And Australian Wine Industry! Trademarks And Gis As A Consumer Magnet?, 118 J. Marshall Rev. Intell. Prop. L. 421 (2019), Sarah Hinchliffe

UIC Review of Intellectual Property Law

In a dense global market, wine is heavily reliant on catering to the needs of consumers. Consumers, as part of the decision-making process, rely on information – comprising information type, and the way that it is portrayed. This article identifies branding opportunities for New World wineries – particularly in the United States and Australia – to capitalize on without compromising innovation in branding nor breaching IP law. It highlights that wineries in the New World have a plethora of opportunity to create a spunk and pizazz effect in their branding. At the same time, it cautions what wineries should avoid …

The Forking Phenomenon And The Future Of Cryptocurrency In The Law, 19 Uic Rev. Intell. Prop. L. 1 (2019), Chelsea Button

UIC Review of Intellectual Property Law

In the evolving and ever-changing world of cryptocurrency, new and exciting phenomena arise, including hard forks. Hard forks occur when two groups supporting a cryptocurrency disagree on how the code should evolve. If the changes are incompatible, the code diverges into two chains, essentially doubling the amount of each holder’s coin. Forking a coin is theoretically easy. However, maintaining a fork requires great effort and support by members of the community. This Article discusses the November 15, 2018 Bitcoin Cash hard fork and subsequent lawsuit, analyzing anti-trust, negligence, and conversion claims. Forcing de facto fiduciary duties on developers and miners …

Developing Zebrafish As An In Vivo Model To Screen Compounds For Anti-Cancer Activity In Human Breast Cancer, Trisha Dhawan

Electronic Theses and Dissertations

Breast Cancer (BC) is the most frequently diagnosed cancer; 1:8 women are at risk of developing BC in her lifetime. Cancer metastasis causes the majority of deaths in BC patients. Moreover, side effects of traditional chemotherapeutic drugs (TCD) impair the quality of life of these patients. Discovery and development of safe and effective new therapies is imperative for the treatment of BC and targeting metastasis. The goal herein is to further expand the applicability of in vivo xenotransplantation of human BC cells in transgenic zebrafish to screen potential chemotherapeutics for toxicity and efficacy. For xenotransplantation, MCF-7, BT-474, and MDA-MB-231 BC …

Weight Teasing Among Obese Youth: Social Functioning Outcomes Following A Pediatric Weight Management Intervention, Joseph Mitchell Magness

Electronic Theses and Dissertations

The prevalence of excess weight and obesity among children and adolescents in the United States continues to increase. Aside from the different effects weight has on a person’s physical and psychological well-being, obese youth often experience poorer social functioning than normal weight peers. Weight teasing is among those highlighted social difficulties. Pediatric weight management program interventions have been shown to improve health-related quality of life (HRQoL) across domains for obese youth. However, few studies have examined the impact of weight management interventions on social quality of life for those with a history of weight teasing. The present study aimed to …

Feedback In The Flipped High School Stem Classroom, Trisha Michele Gilbreath

Electronic Theses and Dissertations

This study examined how much feedback students received in the flipped high school science, technology, engineering and math (STEM) classroom. The flipped classroom is a pedagogical technique where students watch video instruction at home and complete collaborative activities in class. This technique has gained popularity in recent years, especially in STEM classrooms. The literature on the flipped classroom is inconclusive, with studies mainly conducted in higher education. Student and instructor perceptions were often studied, and those perceptions are generally positive about the flipped classroom, though there are concerns to consider. Student performance shows that the flipped classroom is at least …

A Survey On Horse Use And Management In Horse Clubs In China: A Pilot Study, Zhen Li, Zhen Li

Murray State Theses and Dissertations

During the past three decades, significant development of the Chinese equine industry has resulted in a rapid increase in the number of horses in the country. At the same time, many horse clubs face shortages of trained management personnel or specialists in equine science and technology. The objective of this survey was to document and evaluate horse management and use in Chinese horse clubs. A 29-question survey was developed using SurveyMonkey© and tested on a small pilot group before being revised and released to a general pool of participants. The questionnaire link was distributed through WeChat to specific personnel in …

Social Networking Sites And Physical Activity: The Role Of Framed Health Messages, Cassie Gonzalez

Murray State Theses and Dissertations

Cardiovascular disease, cancer, and diabetes are the current leading causes of death in the United States, where most of these diseases are caused by a few specific risk behaviors including tobacco use, poor nutrition, and lack of physical activity (Rutledge, Lane, Merlo, & Elmi, 2018). Healthcare professional are being encouraged to educate patients and the community about the risks associated with health behaviors and lifestyle choices. I explore aspect of these health messages in the context of gain- vs loss-framed messages presented through two social networking sites, Twitter and Instagram, on subsequent health behavior changes. Whereas existing literature have explored …

An Evaluation Of The Racer Academy Of Agriculture And Its Effectiveness, Caleb Brannon

Murray State Theses and Dissertations

Through this thesis research study, an evaluation of the Racer Academy of Agriculture (RAA) is performed to get a better understanding of how well it is doing in several key areas. One of the focus areas for the RAA as well as most other dual credit programs includes allowing high school students to attain college credit through participation in a class that counts both towards high school and collegiate degree completion. Other key objectives for these programs include aiding in the recruitment of students to the participating university, preparing the students to succeed at a higher rate once becoming full-time …

Linking Microbial Community Structure And Ecosystem Functions In Acidic Soil From Pennsylvania, Usa, Madison T. James, Sophia T. Farrisi, Shreya Shah, Vishal Shah

Sustainability Research & Creative Activities Grants Reports

Microorganisms play a critical role in the structure and functioning of soil ecosystems. Within acidic soil across the northeastern United States and Canada, we have little understanding of the microbial diversity present and its relationship to the biochemical cycles. The current study is aimed at understanding the taxonomical and functional diversities in the acidic soil obtained from near various types of trees, how the diversities change as a function of depth, and the linkage between taxonomical and functional diversities. From eight sampling locations, soil samples were collected from three horizons (depths). The three depths were 0-10 cm (A), 11-25 cm …

Failure To Launch, Wellness, And Mentorship, Adriano Roberto Marcoccia

Walden Dissertations and Doctoral Studies

As of 2015, over 34% of emerging adults in the United States between 18 and 34-years-old were still living with their parents or guardians, and prior research has suggested this trend was steadily growing. The current study examined contextual factors, such as an individual's state of well-being during this transitional phase, to determine what, if any, variables may also be contributing to this issue. Both Adlerian theory and social exchange theory were used as the theoretical foundation to better understand how to mitigate this phenomenon. Amazon MTURK was used to recruit 336 participants who completed the survey. A series of …

Social-Emotional Support As A Mediator Of Household Structure And Mental Distress In Women, Trisha Jeanine Walker

Walden Dissertations and Doctoral Studies

Mental illness affects more women than men in the United States. Poor mental health in reproductive-age women has negative implications on population health. The purpose of this quantitative, correlational study was to examine the relationship between household structure and frequency of mental distress, with consideration of the mediation social-emotional support provides for reproductive-age women. The social ecological model was the theoretical framework for this research, in which frequency of mental distress related to the individual-level of the human-environment interaction construct. Household structure and social-emotional support were examined at the relationship-level. Pearson's correlation coefficient and linear regression were used to conduct …

Natural Environment Associations With Mental Health And Obesity Status, Adam Edwin London

Walden Dissertations and Doctoral Studies

Mental health and obesity were ranked among the health priorities of the 2014 and 2017 Community Health Needs Assessments in Kent County, Michigan. Exposure to nature is correlated to improved health outcomes across a variety of morbidities including poor mental health and obesity. This cross-sectional study set within the frameworks of attention restoration theory, environmental health, and pathways to health benefits from nature assessed county survey data including self-reported nature exposures/interactions separated into 3 domain areas: access to nature, attitudes about nature, and physical activity in nature or in nature-based activities. Binary logistic regression analyses of the 653 respondents found …

Middle School Mathematics Teachers' Perception Of Socioeconomic Status And Effects On Instruction, Kristen A. Jones

Walden Dissertations and Doctoral Studies

In a small but diverse suburban school district, the gap in mathematics performance between economically disadvantaged and economically nondisadvantaged students was slowly widening as evidenced by state test scores. The purpose and key research questions of this instrumental case study were designed to (a) identify what Grades 6, 7 and 8 mathematics teachers perceive the role socioeconomic status plays in ability to learn mathematics and to (b) understand what teachers believe affects their perceptions of students' ability to learn mathematics. The conceptual framework guiding this study was social reproduction theory. The nine participants were middle school (i.e., Grades 6, 7 …

Physical Activity And Dietary Interventions For Adolescent African Americans In Mississippi, Tanga Deson Hart Robinson

Walden Dissertations and Doctoral Studies

African American (AA) adolescents have higher rates of obesity than many other ethnic groups, which increases their risk for obesity-related diseases. Culturally sensitive obesity preventive interventions have been unsuccessful, resulting in a steady increase of obesity among AA adolescents. AA adolescents in the southern region of the United States are at a higher risk for obesity and physical inactivity; knowledge and understanding of causative factors remains limited. To identify the impact of programs, a systematic review of the literature focused on structured physical activity and/or dietary education interventions in Mississippi. The ecological framework was used to guide this study. The …

Nursing Knowledge On Pressure Injury Prevention In The Intensive Care Unit, Yanick Jacob

Walden Dissertations and Doctoral Studies

Over 60,000 hospital patients die each year from complications associated with hospital-acquired pressure injuries (HAPIs). Pressure-injury rates have increased by 2% within the past decade as life expectancy has also increased due to high cost in Medicare. Evidence shows that the incidence of pressure injuries (PIs) in healthcare facilities is increasing, with high rates of occurrence in intensive care units (ICUs). At the clinical site for which this project was developed, multiple in-services had been provided to staff regarding PIs, but uncertainty persisted about how knowledgeable the nurses were. This project, using the Academic Center for Evidence Star Model of …

Physical Activity, Healthcare Use, And Medication Use In Diabetes Patients, Julie Kwon Evans

Walden Dissertations and Doctoral Studies

Physical Activity, Healthcare Use, and Medication Use in Diabetes Patients

by

Julie Kwon Evans

MS, The Chicago School of Professional Psychology, 2013

Dissertation Submitted in Partial Fulfillment

of the Requirements for the Degree of

Doctor of Philosophy

Psychology

Walden University

November 2019

Associations Between Healthcare Utilization Factors And Diabetic Retinopathy Among Adult African Americans, Olusina Adesanya

Walden Dissertations and Doctoral Studies

African Americans are disproportionately affected by diabetes mellitus (DM) and complications that include diabetic retinopathy and its disease and socioeconomic burdens. This study examined the relationships between diabetic retinopathy and health care utilization factors, such as gender, DM comorbidities of hypertension and hyperlipidemia, and health care access, among sampled African Americans with DM in the United States. The Andersen health care utilization model was the framework for the study. In this correlational cross-sectional study, data from the 2011-2016 National Health and Nutrition Examination Survey datasets were analyzed. Results of complex samples logistic regression showed that there were no significant associations …

Influence Of Educational Equity Policies On High School Graduation Rates For Black Students, Vincent Kiriza Chirimwami

Walden Dissertations and Doctoral Studies

The achievement gaps between White and Black students remain prevalent in American public schools. To resolve the problem, many school districts have developed equity-centered practices to improve high school graduation rates. The purpose of this quantitative study was to determine whether the (a) duration of exposure to educational equity policies, (b) percentage of economically disadvantaged students, (c) percentage of students with disabilities, and (d) percentage of limited-English-proficient (LEP) students are predictive of high school graduation rates for Black students in large school districts. This study was grounded in Schneider and Ingram’s social construction of target populations theory. Archival data of …