Digital Commons Network^™

Further Analyses Of The Safety Of Verubecestat In The Phase 3 Epoch Trial Of Mild-To-Moderate Alzheimer’S Disease, Michael F. Egan, Yuki Mukai, Tiffini Voss, James Kost, Julie Stone, Christine Furtek, Erin Mahoney, Jeffrey L. Cummings, Pierre N. Tariot, Paul S. Aisen, Bruno Vellas, Christopher Lines, David Michaelson

Integrated Health Sciences Faculty Research

Background: Verubecestat, a BACE1 inhibitor that reduces Aβ levels in the cerebrospinal fluid of humans, was not effective in a phase 3 trial (EPOCH) of mild-to-moderate AD and was associated with adverse events. To assist in the development of BACE1 inhibitors, we report detailed safety findings from EPOCH. Methods: EPOCH was a randomized, double-blind, placebo-controlled 78-week trial evaluating verubecestat 12 mg and 40 mg in participants with mild-to-moderate AD diagnosed clinically. The trial was terminated due to futility close to its scheduled completion. Of 1957 participants who were randomized and took treatment, 652 were assigned to verubecestat 12 mg, 652 …

Evaluating The Efficacy Of Point-Of-Use Water Filtration Units In Fiji, Nathan L. Tintle, Adam Heynen, Kristin Van De Griend, Rachel Ulrich, Matthew Ojo, Emma Boven, Sarah Brokus, Randall Wade, Aaron A. Best

Faculty Work Comprehensive List

Background: To develop and evaluate a strategy for reducing the prevalence and impact of waterborne disease, a water quality intervention was developed for Fiji by Give Clean Water, Inc. in partnership with the Fiji Ministry of Health. Residents were provided and trained on how to use a Sawyer® PointONE™ filter, while also being taught proper handwashing techniques. At the time of the filter installation, all households were surveyed inquiring about the prior 2- to 4-week period. Households were measured a second time between 19 and 225 days later (mean = 66 days).

Results: To date, five economic and health outcomes …

The Parthenon, August 7, 2019, Hanna Pennington

The Parthenon

The Parthenon, Marshall University’s student newspaper, was published by students Monday through Friday during the regular semester and weekly on Thursdays during the summer. Due to budgetary constraints, beginning with the 2018 Fall semester, the newspaper is only published one day a week (and once every other week during the summer). The editorial staff is responsible for the news and the editorial content.

Genome-Edited Animals Are Not Transgenic Animals: Moving Toward Responsible Research And Innovation With New Biotechnologies, Yvie Yao

Minnesota Journal of Law, Science & Technology

No abstract provided.

Short- And Long-Term Social Effects Of Parental Sex Roles In Zebra Finches, Ákos Pogány, Boglárka Morvai, E. Tobias Krause, Eugene Kitsios, Thijs Böhm, Tim Ruploh, Nikolaus Von Engelhardt, Tamás Székely, Jan Komdeur, Ádám Miklósi, Oliver Krüger

School of Biological and Marine Sciences

No abstract provided.

Effects Of Visit Frequency On Swallowing Function During Organ Preservation For Head And Neck Cancer, Mathew Blaine Vansant

LSU Doctoral Dissertations

Chemoradiotherapy is not without risk of injury to the muscles and nerves associated with swallowing function. Current research supports the use of prophylactic behavioral swallowing exercise in the HNC population, however, wide variations in swallowing treatment methodologies exist and no optimal SLP-patient visit frequency has been established. In addition, poor patient adherence to swallowing exercise appears prevalent. The current study explored the impact of speech language pathologist (SLP)-patient contact time, adherence to prophylactic behavioral swallowing exercises, and explored effects of exercise intensity on immediate post-radiation swallowing outcomes. Groups included a high frequency group (5 weekly SLP-patient visits, n = 15), …

Sub-Fields And Countries In The Literature Of Gout: An Analysis, Ramakrishnan Jagannathan, Ravi Sankar G, Kotti Thavamani

Library Philosophy and Practice (e-journal)

This paper presents an analysis of Sub-Fields and Countries in the literature of Gout using bibliometric techniques. The literature covered in the database for the period 2008-2017 was considered. It shows that there is a growth of literature in the subject of study by year after year. 40.44% records were covered by Journal Article. 51 journals were needed to supply one-third of the cited records for zone-1. However, 223 journals were required to produce the second grouping of records in Zone-2, and 725 journals to yield the records that constitute Zone-3. Most frequently cited primary journals were General Medicine in …

An Epidemiological Study Of Diabetes Mellitus In Dogs Attending First Opinion Practice In The Uk, Madeleine Mattin, Dan G. O'Neill, David B. Church, Paul D. Mcgreevy, Peter C. Thomson, Dave C. Brodbelt

Epidemiology Collection

Objectives: To estimate the prevalence of canine diabetes mellitus (DM) in primarycare clinics in England, to identify risk factors associated with DM and to describe the survival of affected dogs.

Methods: Cases of DM were identified within the electronic patient records of 89 small-animal practices. A nested case-control study identified risk factors for the diagnosis of DM using logistic regression models. Cox proportional hazards models were used to analyse variables associated with survival.

Results: Four-hundred and thirty-nine canine DM cases were identified, giving an apparent prevalence of 0.34% (95% confidence interval 0.31 - 0.37%). Neutered males were at an increased …

Weight Gain Trajectory And Pain Interference In Young Adulthood: Evidence From A Longitudinal Birth Cohort Study, Jamie Lynch

Faculty Creative and Scholarly Works

Introduction: Obesity is associated with chronic pain, but the contribution of body mass index (BMI) trajectories over the life course to the onset of pain problems remains unclear. We retrospectively analyzed how BMI trajectories during the transition to adulthood were associated with a measure of pain interference obtained at age 29 in a longitudinal birth cohort study.

Methods: Data from the National Longitudinal Survey of Youth, 1997 Cohort (follow-up from 1997 to 2015) were used to determine BMI trajectories from age 14 to 29 via group trajectory modeling. At age 29, respondents described whether pain interfered with their work inside …

2019-August-06-Researchers Secure Nih Grant To Study Childhood Obesity Risk Factors, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

“And They Shall Eat Until They Are Satisfied:” Critical Disability Theory And Widows, Orphans, Aliens, And Levites In The Book Of Deuteronomy, Cheryl Strimple

Religious Studies Theses and Dissertations

This dissertation considers the construction of widows, orphans, aliens, and Levites in deuteronomic law. Making use of multiple methodologies, literary criticism, Disability Studies, and food and foodway studies, this study argues that, in Deuteronomy, the members of the formulaic reference, “the alien, the orphan, and the widow,” often associated with “the Levite” operate as cultic functionaries and participate in cultic meals in order to secure stability and continuing abundance in the land for all of Israel.

Peroxiredoxin 6 And Phospholipids In Alzheimer's Disease, Nathan A. Drolet

Biological Sciences Theses and Dissertations

Although many neurological mechanisms that contribute to Alzheimer’s disease (AD) have been elucidated, none so far have yielded treatments that can improve AD patient prognosis or slow progression of the disease. Oxidative stress and inflammation in the brain have been identified as major hallmarks of AD, and studies suggest these phenomena induce neurodegeneration. However, connections between AD and the development of these symptoms remain poorly understood. The redox regulator Prx6 has been implicated by studies in humans and mice as a potential mediator between these phenomena. Prx6 may be able to influence oxidative stress and inflammation simultaneously using its peroxidase …

Clinical Trial Design And Analysis, Shuang Li

Statistical Science Theses and Dissertations

Clinical trials are experiments tested on human to compare the effect of certain intervention. In early-stage trials, fewer number of patients are enrolled to get preliminary information on safety and efficacy. In late-stage trials, larger number of patients are randomized to further confirm the efficacy and safety.

In Chapter 2, we propose a family of designs for phase I oncology trials. In these trials, oncologists assign different patients at a varying range of dose levels to find the dose that gives the highest acceptable rate of dose-limiting toxicities, which will be the recommended dose for phase II trials. Our proposed …

Retired Female Gymnasts' Reflections On Body Image And Sense Of Self, Briley Casanova

LSU Master's Theses

Researchers identify the early stages of retirement as a key developmental period when many female athletes struggle with both body image disturbances and changes to identity. Body image disturbances and changes to identity may be especially challenging for former female athletes participating in aesthetic focused sports such as gymnastics, because physical appearance plays an important role in elite performance. This study utilized semi-structured, in-depth interviews with five former NCAA Division I artistic gymnasts to learn about their experiences and perceptions of body image and athletic identity in the early stages of retirement. Three main themes emerged from the interviews: (a) …

Decomposing Trends In Child Obesity, Ashley Wendell Kranjac, Robert L. Wagmiller

Sociology Faculty Articles and Research

We unravel the absolute level and relative prominence of two demographic processes that are relevant for childhood obesity, and that will ultimately determine the long-term course and pace of change in child obesity rates. We leverage data from the National Health and Nutrition Examination Survey to decompose change in child obesity from 1971 to 2012. We partition change into that attributable to (1) healthier, more nutritionally and economically advantaged cohorts in the population being replaced by cohorts of children who are less advantaged (between-cohort change), and (2) the health habits, nutrition, and social and economic circumstances of all cohorts of …

Association Of Baseline Inflammatory Biomarkers With Cancer Mortality In The Regards Cohort, Tomi Akinyemiju, Justin X. Moore, Maria Pisu, Michael Goodman, Virginia J. Howard, Monika Safford, Susan C. Gilchrist, Mary Cushman, Leann Long, Suzanne E. Judd

Open Access Publications

This study examines the association between inflammatory biomarkers and risk of cancer mortality by race. Data were obtained from 1,856 participants in the prospective REGARDS cohort who were cancer-free at baseline, and analyzed in relation to cancer mortality prospectively. Biomarkers were log-transformed and categorized into tertiles due to non-normal distributions, and Cox proportional hazard regression models were utilized to compute hazard ratios with 95% confidence intervals using robust sandwich methods. Individuals in the highest tertile of IL-6 had over a 12-fold increased risk of cancer mortality (HR: 12.97, 95% CI: 3.46-48.63); those in the highest tertile of IL-8 had over …

Robert Cordaro V. Usa

2019 Decisions

USDC for the Middle District of Pennsylvania

Examining The Youth Multi-Sport Event Environment: Implications Towards Athlete Development And Transitioning., Eric Macintosh, Keita Kinoshita, Michael L. Naraine, Shintaro Sato

Journal of Athlete Development and Experience

Many factors are associated with a person’s attitude formation and intention towards a behavior. In this study, we examined organizational factors that helped form young athletes attitudes regarding their future plans in high performance sport. Through a mixed method survey design, data was collected from 207 young pre-elite athletes who competed during the 2017 Commonwealth Youth Games in Bahamas. Several organizationally controlled aspects of the games environment were found to contribute to young athlete’s satisfaction with the event including their accommodations, available information regarding their sport and finally, the social and cultural activities during games-time. However, satisfaction with the games …

Innovative Solutions For State Medicaid Programs To Leverage Their Data, Build Their Analytic Capacity, And Create Evidence-Based Policy, Lauren Adams, Susan Kennedy, Lindsay Allen, Andrew Barnes, Tom Bias, Dushka Crane, Paul Lanier, Rachel Mauk, Shamis Mohamoud, Nathan Pauly, Jeffery C. Talbert, Cynthia Woodcock, Kara Zivin, Julie Donohue

Pharmacy Practice and Science Faculty Publications

As states have embraced additional flexibility to change coverage of and payment for Medicaid services, they have also faced heightened expectations for delivering high-value care. Efforts to meet these new expectations have increased the need for rigorous, evidence-based policy, but states may face challenges finding the resources, capacity, and expertise to meet this need. By describing state-university partnerships in more than 20 states, this commentary describes innovative solutions for states that want to leverage their own data, build their analytic capacity, and create evidence-based policy. From an integrated web-based system to improve long-term care to evaluating the impact of permanent …

An Event-Related Potential Study Of Inhibition To Sugar-Sweetened Beverages, Hanel Watkins

Undergraduate Honors Theses

In the United States, the intake of sugar-sweetened beverages per capita from 1977 to 2002 doubled across all age groups. One factor that may contribute to the consumption of sugar-sweetened beverages is inhibitory control, or the ability to withhold a dominant response in order to correctly respond to one’s environment. Studies suggest that increased recruitment of inhibitory control resources plays a role in decreasing the consumption of high-calorie foods and that strengthening an individual’s inhibitory control may help them manage their food intake. However, the neural response to sugar-sweetened beverages versus non-sweetened beverages is unknown. Thus, we tested event-related potential …

Assessment Of Nutritional Status Using Anthropometric Variables By Multivariate Analysis, Ankita Bhattacharya, Baidyanath Pal, Shankarashis Mukherjee, Subrata Kumar Roy

Journal Articles

Background: Undernutrition is a serious health problem and highly prevalent in developing countries. There is no as such confirmatory test to measure undernutrition. The objective of the present study is to determine a new Composite Score using anthropometric measurements. Composite Score was then compared with other methods like body mass index (BMI) and mid-upper arm circumference (MUAC) classification, to test the significance of the method. Methods: Anthropometric data were collected from 780 adult Oraon (Male = 387, Female = 393) labourers of Alipurduar district of West Bengal, India, following standard instruments, and protocols. Nutritional status of the study participants were …

Bjc Today

BJC Today

No abstract provided.

Summer Graduation August 2019, Andrews University

Andrews Agenda: Campus News

No abstract provided.

Higher Pro-Inflammatory Dietary Score Is Associated With Higher Hyperuricemia Risk: Results From The Case-Controlled Korean Genome And Epidemiology Study_Cardiovascular Disease Association Study, Hye Sun Kim, Minji Kwon, Yi Hyun Lee, Nitin Shivappa, James R. Hebert, Cheongmin Sohn, Woori Na, Mi Kyung Kim

Faculty Publications

In previous studies, the elevated dietary inflammatory index (DII^®) scores have been consistently associated with several chronic diseases. However, the relationship with hyperuricemia remains unknown. The aim of this study was to determine if the DII is associated with hyperuricemia risk. The study included 13,701 participants (men 5102; women 8599) in a large-scale cross-sectional study in South Korea. A validated semi-quantitative food frequency questionnaire (SQFFQ) was used to measure dietary intake, and blood samples were obtained to determine hyperuricemia. As the DII score increased, the hyperuricemia risk increased among women (OR 1.35, 95% CI 1.03–1.77, p trend = …

Incidence And Prevalence Of Francisella Noatunensis Subsp. Orientalis (Fno) Pathogenic Infections In Feral Hawaiian Tilapia, Daquille Peppers

Biology Theses

Aquaculture has become a major food source for many countries and continues to grow each year. However, many of the fishes that are farmed are susceptible to pathogenic infections such as Francisellosis, a bacterial infection that contributes to disease and high mortality rate in many populations of farmed and wild fish around the world. In 1994, feral and farmed populations of tilapia (e.g. Oreochromis mossambicus) on Oahu, Hawaii were found to be infected with a novel Francisellosis strain, Francisella noatunensis subsp. orientalis (Fno). To prevent the spread of this pathogen, the Hawaii Department of Aquaculture (HDOA) initiated …

Chronic Condition Patterns In The Us Population And Their Associations With Health Outcomes, Dandan Diane Zheng

Open Access Dissertations

Advances in modern medicine have substantially increased life expectancy and improved the outcomes of previously fatal diseases. As a result, more and more people are living into old age and developing chronic conditions. Persons with multiple chronic conditions are more likely to be hospitalized, have poor daily functioning, and elevated risk of death. A disproportionate share of health expenditures is incurred by individuals with multiple chronic conditions. Visual impairment (VI) is among the most disabling conditions. VI and visual disorders often co-occur with other disabling chronic conditions. The health effects of living with multiple chronic conditions in the presence of …

On Generalization Of Tweedie Distribution: A Bayesian Perspective, Tairan Ye

Doctoral Dissertations

With nonnegative support and discrete mass at zero, the Tweedie model becomes a popular method to analyze the continuous zero-spike data, which is fairly common in fields of insurance, biostatistics, epidemiology, economics, and geography. Several research articles had discussed other approaches to model data with mass zeros, especially the zero-inflated exponential family of distributions, including the zero-inflated gamma model and the zero-inflated log-normal distribution. However, no systematical comparison has been conducted to select the best model for the excess-zero data, which motivated us to propose a model comparison between the Tweedie model and other zero-inflated models under the Bayesian framework. …

Water Productivity In Meat And Milk Production In The Us From 1960 To 2016, Mesfin Mekonnen, C.M.U. Neale, Chittaranjan Ray, Galen E. Erickson, Arjen Y. Hoekstra

Daugherty Water for Food Global Institute: Faculty Publications

Global demand for livestock products is rising, resulting in a growing demand for feed and potentially burdening freshwater resources to produce this feed. To offset this increased pressure on water resources, the environmental performance of livestock sector should continue to improve. Over the last few decades, product output per animal and feedstuff yields in the US have improved, but before now it was unclear to what extent these improvements influenced the water productivity (WP) of the livestock products. In this research, we estimate changes in WP of animal products from 1960 to 2016. We consider feed conversion ratios (dry matter …

Dietary Inflammatory Index And Its Relationship With Cervical Carcinogenesis Risk In Korean Women: A Case-Control Study, Sundara Raj Sreeja, Hyun Yi Lee, Minji Kwon, Nitin Shivappa, James R. Hébert, Mi Kyung Kim

Faculty Publications

Several studies have reported that diet’s inflammatory potential is related to chronic diseases such as cancer, but its relationship with cervical cancer risk has not been studied yet. The aim of this study was to investigate the association between Dietary Inflammatory Index (DII^®) and cervical cancer risk among Korean women. This study consisted of 764 cases with cervical intraepithelial neoplasia (CIN)1, 2, 3, or cervical cancer, and 729 controls from six gynecologic oncology clinics in South Korea. The DII was computed using a validated semiquantitative Food Frequency Questionnaire (FFQ). Odds ratios and 95% CI were calculated using multinomial …

Assessment Of The Public Value Of Open Data In Ghana, Hubeidatu Nuhu, Jean-Paul Van Belle

African Conference on Information Systems and Technology

With rising enthusiasm for Open Data (OD) globally, there has been an expanding requirement for research on the impact this movement has created. Ghana is consid-ered as one of the early Open Data adopters in Africa. The case of Ghana presents an interesting and a unique area of concentration due to the country’s long stand in de-mocracy. The practice of democracy, accountability and transparency has been the core of government development in Ghana since independence in 1957. The research pur-pose is to understand and examine the impact of Open Data from the context of Gha-na from the perspective of created …