Digital Commons Network^™

Healthy People 2020: Identifying Roles For Pharmacists In Public Health, Ellen Hazelet, Aisha Oliver, Katherine Salay, Breanne Rizzo, Alison L. Huet, Natalie Dipietro

Pharmacy and Wellness Review

Healthy People, sponsored by the United States Department of Health and Human Services, utilizes evidence-based medicine to create objectives addressing significant preventable health issues. The vision of Healthy People is to improve the quality and length of life free from preventable disease, disability, injury and death. Based on objectives outlined by Healthy People 2020 (HP 2020) pharmacists can play a role in public awareness, collaborate with other health care professionals and help achieve goals set forth by HP 2020. Based on the expertise and accessibility of the pharmacist, pharmacists can impact nine of the 13 new focus areas pf HP …

Will New Mrsa Guidelines Make A Difference In Clinical Outcomes? A Comparison Of United States And United Kingdom Guidelines And Outcomes, Kelly Fargo, Erica Schoenberger, Kristen Thatcher, Lindsey Hallman, Andrew Roecker, Tarek Mahfouz

Pharmacy and Wellness Review

As of February 2011, the Infectious Disease Society of America (IDSA) published the first guidelines assessing the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. S. aureus is present in the environment and is also located on the skin's surface. MRSA can cause a variety of clinical syndromes presenting with different symptoms that vary with the type and stage of the infection. MRSA is also classified into community-acquired MRSA (CA-MRSA) and hospital-acquired (HA-MRSA), both of which possess different treatment options and strategies. Due to the complex treatment of MRSA, as well the concern over the development of resistance, suggested treatment guidelines …

Conservation Risk Of Batrachochytrium Salamandrivorans To Endemic Lungless Salamanders, Edward Davis Carter, Debra L. Miller, Anna C. Peterson, William B. Sutton, Joseph Patrick W. Cusaac, Jennifer A. Spatz, Louise Rollins-Smith, Laura Reinert, Markese Bohanon, Lori A. Williams, Andrea Upchurch, Matthew J. Gray

Agricultural and Environmental Sciences Faculty Research

The emerging fungal pathogen, Batrachochytrium salamandrivorans (Bsal), is a significant conservation threat to salamander biodiversity in Europe, although its potential to affect North American species is poorly understood. We tested the susceptibility of two genera (Eurycea and Pseudotriton) and three populations of lungless salamanders (Plethodontidae) to Bsal. All species became infected with Bsal and two (Pseudotriton ruber and Eurycea wilderae) developed chytridiomycosis. We also documented that susceptibility of E. wilderae differed among populations. Regardless of susceptibility, all species reduced feeding when exposed to Bsal at the highest zoospore dose, and P. ruber and one population of E. wilderae used cover …

Double-Crested Cormorant Colony Effects On Soil Chemistry, Vegetation Structure And Avian Diversity, Leah Moran Veum, Brian S. Dorr, Katie C. Hanson-Dorr, R.J. Moore, Scott A. Rush

United States Department of Agriculture Wildlife Services: Staff Publications

Effects of Double-crested Cormorants (Phalacrocorax auritus) on vegetation, soil chemistry and tree health have been documented from their breeding colonies in the northern breeding grounds of Canada and the United States (U.S.) but not for areas within the southeastern United States where breeding activity is relatively novel. We compared vegetation and tree metrics such as structure diversity, and soil chemistry among colony islands, uninhabited islands, and abandoned colony islands within Guntersville Reservoir, a temperate forest ecosystem. Avian diversity and community structure were also quantified on these islands. Concentrations of potassium (K), phosphorus (P) and nitrate (NO3 −) in soil were …

Uab Cfar Researchers Awarded Contracts To Aid The Ending The Hiv Epidemic Plan, Alicia Rohan

Browse All News

No abstract provided.

Endovascular Management And The Risk Of Late Failure In The Treatment Of Ureteroarterial Fistulas, George Titomihelakis, Anthony Feghali, Tuong Nguyen, Dawn Salvatore, Paul Dimuzio, Babak Abai

Department of Medicine Faculty Papers

Ureteroarterial fistula (UAF) is a rare and life-threatening source of hematuria. A high index of suspicion is warranted for early diagnosis and timely intervention. Because of high perioperative risk and comorbidities in UAF patients, the endovascular approach has become preferred for repair. Infection can complicate this mode of therapy, and treatment with antibiotics is important. Herein we present five cases of secondary UAFs treated with stent graft alone or stent graft and embolization.

Pharmacotherapeutic Study Of Antiretroviral Therapy For Hiv/Aids Patients At The Federal Medical Centre, Owo, Ondo State, Nigeria, Isiaka Adebowale Ayeni Pharm., Adelanwa Oludele Itiola Prof, Tajudeen Temitayo Adebayo Dr.

Library Philosophy and Practice (e-journal)

A 6-12 months retrospective study is made of HAART utilization in cases of HIV/AIDS patients at Federal Medical Centre, Owo, Nigeria. The objective to evaluate the rational pharmacotherapeutic approach to the management of the retroviral disease. Sixty two (62) antiretroviral drug-naive HIV/AIDS patients, which comprise of (19) 30.65% males with a mean age of 37.15±8.55 years and (43) 69.35% females with a mean age of 35.68±9.75 years case files are reviewed. The data used for this study was extracted from the clinical records of the Hospital. Sixty six percent of the patients are at World Health Organization (WHO) clinical stage …

Closed-Form Probability Distribution Of Number Of Infections At A Given Time In A Stochastic Sis Epidemic Model, Olusegun M. Otunuga

Mathematics Faculty Research

We study the effects of external fluctuations in the transmission rate of certain diseases and how these affect the distribution of the number of infected individuals over time. To do this, we introduce random noise in the transmission rate in a deterministic SIS model and study how the number of infections changes over time. The objective of this work is to derive and analyze the closed form probability distribution of the number of infections at a given time in the resulting stochastic SIS epidemic model. Using the Fokker-Planck equation, we reduce the differential equation governing the number of infections to …

Adoption And Usage Of Web-Based Library Resources And Services: An Investigation Of Icddr,B Library In Bangladesh, Md. Nazim Uddin, M. Al Mamun, Md. Shafiur Rahman

Library Philosophy and Practice (e-journal)

Purpose – The core purpose of this study is to explore the web-based library services available in icddr,b Library. In addition, this research aims to investigate the adoption and utilisation of subscribed, registered and open access e-resources by the scientists and researchers at icddr,b Library. The existing facilities that influenced smooth usage of web-based information services of icddr,b library have been assessed. The study involved scientists and researchers of icddr,b.

Design/methodology/approach – The study used a mixed-method research design using case study approach. Both qualitative and quantitative approaches were used. An online survey was conducted in June 2017 to ascertain …

Multispectral Tracing In Densely Labeled Mouse Brain With Ntracer, Douglas H Roossien, John M Webb, Cristina Mazuski, Erik D Herzog, Et Al.

2010-2019 OA Pubs

SUMMARY: This note describes nTracer, an ImageJ plug-in for user-guided, semi-automated tracing of multispectral fluorescent tissue samples. This approach allows for rapid and accurate reconstruction of whole cell morphology of large neuronal populations in densely labeled brains.

AVAILABILITY AND IMPLEMENTATION: nTracer was written as a plug-in for the open source image processing software ImageJ. The software, instructional documentation, tutorial videos, sample image and sample tracing results are available at https://www.cai-lab.org/ntracer-tutorial.

SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Pathogenic Interplay Between Chlamydia Trachomatis And Neisseria Gonorrhoeae That Influences Management And Control Efforts—More Questions Than Answers?, Cory Ann Leonard, Robert V. Schoborg, Nicola Low, Magnus Unemo, Nicole Borel

ETSU Faculty Works

Purpose of Review: To emphasize key gaps in knowledge impacting efforts to control single infection and co-infections with Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), the most common bacterial sexually transmitted infections (STIs) worldwide. Recent Findings: Clinical and epidemiological studies describe gaps in understanding about female rectal CT infection, screening effectiveness, pelvic inflammatory disease, and influence of the microbiome. For NG, gaps in knowledge include factors increasing incidence in men who have sex with men, correlations between treatment and antibiotic resistance, the role of pharyngeal infection, and microbiome influence. CT/NG co-infections are poorly understood, and adequate models to explore pathophysiological …

How Il-6 Allows The Immune Response To Develop For A Key Cell, The T Follicular Helper, Jeff Hansen

Browse All News

No abstract provided.

Endoglin Protein Interactome Profiling Identifies Trim21 And Galectin-3 As New Binding Partners, Eunate Gallardo-Vara, Lidia Ruiz-Llorente, Juan Casado-Vela, María J. Ruiz-Rodríguez, Natalia López-Andrés, Asit K. Pattnaik, Miguel Quintanilla

School of Veterinary and Biomedical Sciences: Faculty Publications

Endoglin is a 180-kDa glycoprotein receptor primarily expressed by the vascular endothelium and involved in cardiovascular disease and cancer. Heterozygous mutations in the endoglin gene (ENG) cause herediatry hemorrhagic telangiectasia type 1, a vascular disease that presents with nasal and gastrointestinal bleeding, skin and mucosa telangiectase, and arteriovenous malformations in internal organs. A circulating form of endoglin (alias soluble endoglin, sEng), proteolytically released from the membrane-bound protein, has been observed in several inflammation-related pathological conditions and appears to contribute to endothelial dysfunction and cancer development through unknown mechanisms. Membrane-bound endoglin is an auxiliary component of the TGF-B receptor complex and …

Influence Of Social Isolation During Prolonged Simulated Weightlessness By Hindlimb Unloading, Candice G.T. Tahimic, Amber M. Paul, Ann-Sofie Schreurs, Samantha M. Torres, Linda Rubinstein, Sonette Steczina

Publications

The hindlimb unloading (HU) model has been used extensively to simulate the cephalad fluid shift and musculoskeletal disuse observed in spaceflight with its application expanding to study immune, cardiovascular and central nervous system responses, among others. Most HU studies are performed with singly housed animals, although social isolation also can substantially impact behavior and physiology, and therefore may confound HU experimental results. Other HU variants that allow for paired housing have been developed although no systematic assessment has been made to understand the effects of social isolation on HU outcomes. Hence, we aimed to determine the contribution of social isolation …

Networkfleming Symposium: Update On Quality, Patient Safety And Wellness, Matthew M. Mccambridge Md, Ms, Facp, Fccp

Fleming Infection Prevention and Infectious Disease Symposium

Objective:

Examine how provider wellness is foundational to providing high-quality and safe care.

Behind The Scenes Of “To Err Is Human”, Mike Eisenberg

Fleming Infection Prevention and Infectious Disease Symposium

Objective:

Illustrate how public awareness of medical errors can improve patient safety.

Reducing The Risk For Surgical Site Infections: Will Evidence-Based Practices Really Lead Us To The Promised Land?, Charles E. Edmiston Jr., Phd, Sm (Ascp), Cic (Cbic)

Fleming Infection Prevention and Infectious Disease Symposium

No abstract provided.

You May Be Prepared, But Are You Ready?, Michael Consuelos Md, Mba

Fleming Infection Prevention and Infectious Disease Symposium

Objective:

Explain how planning and preparation is required to achieve readiness for infectious diseases.

Agenda, Lehigh Valley Health Network

Fleming Infection Prevention and Infectious Disease Symposium

No abstract provided.

17-09 Assessing The Impact Of Air Pollution On Public Health Along Transit Routes, Stephen Mattingly, Kyung (Kate) Hyun, Shirin Kamali Rad, Mehrdad Arabi, Sina Famili

Transportation Research Center Reports

Transportation sources account for a large proportion of the pollutants found in most urban areas. Also, transportation activity and intensity appear likely to contribute to the risk of respiratory disease occurrence. This research investigates the impacts of transportation, urban design and socioeconomic characteristics on the risk of air pollution-related respiratory diseases in two of the biggest MSAs (Metropolitan Statistical Areas) in the US, Dallas-Fort Worth (DFW) and Los Angeles at the block group (BG) level, by considering the US Environmental Protection Agency’s respiratory hazard quotient (RHQ) as the dependent variable. The researchers identify thirty candidate indicators of disease risk from …

9th Annual Postdoctoral Science Symposium, University Of Texas Md Anderson Cancer Center Postdoctoral Association

Annual Postdoctoral Science Symposium Abstracts

The mission of the Annual Postdoctoral Science Symposium (APSS) is to provide a platform for talented postdoctoral fellows throughout the Texas Medical Center to present their work to a wider audience. The MD Anderson Postdoctoral Association convened its inaugural Annual Postdoctoral Science Symposium (APSS) on August 4, 2011.

The APSS provides a professional venue for postdoctoral scientists to develop, clarify, and refine their research as a result of formal reviews and critiques of faculty and other postdoctoral scientists. Additionally, attendees discuss current research on a broad range of subjects while promoting academic interactions and enrichment and developing new collaborations.

Sandy Soil Improvement Through Microbially Induced Calcite Precipitation (Micp) By Immersion, Shihui Liu, Kang Du, Wei Huang, Lin Li

Civil and Architectural Engineering Faculty Research

The goal of this article is to develop an immersion method to improve the microbially induced calcite precipitation (MICP) treated samples. A batch reactor was assembled to immerse soil samples into cementation media. The cementation media can freely diffuse into the soil samples in the batch reactor instead of cementation media being injected. A full contact flexible mold, a rigid full contact mold, and a cored brick mold were used to prepare different soil sample holders. Synthetic fibers and natural fibers were selected to reinforce the MICP-treated soil samples. The precipitated CaCO3 in different areas of the MICP-treated samples was …

An Overview Of The Health Profile Of Syrian Refugees Arriving In Kentucky From 2012-2017, Camila Calderon, Annie Rominger

Journal of Refugee & Global Health

Background:

The civil unrest in Syria has led to millions of displaced Syrians. The United States has relocated over 15,000 Syrian refugees, mostly arriving since 2015. Little is known about the health of Syrian refugees entering the United States.

Methods:

Syrian refugees in Kentucky who had a medical screening and documented RHA from October 2012 to September 2017 were included in the study. The information is collected and stored in the Arriving Refugee Informatics Surveillance and Epidemiology (ARIVE) database. This study is a retrospective review of the ARIVE database to describe the general health of the Syrian refugees …

Identification Of 4-Amino-Thieno[2,3-D]Pyrimidines As Qcrb Inhibitors In Mycobacterium Tuberculosis, Gregory A Harrison, Anne E Mayer Bridwell, Megh Singh, Keshav Jayaraman, Leslie A Weiss, Rachel L Kinsella, Janessa S Aneke, Kelly Flentie, Miranda E Schene, Margaret Gaggioli, Samantha D Solomon, Scott A Wildman, Marvin J Meyers, Christina L Stallings

Open Access Publications

Antibiotic resistance is a global crisis that threatens our ability to treat bacterial infections, such as tuberculosis, caused by

Seaweeds As Nutraceuticals For Health And Nutrition, Emer Shannon, Nissreen Abu-Ghannam

Articles

Throughout human history, seaweeds have been used as food, folk remedies, dyes, and as mineral-rich fertilisers. Seaweeds as nutraceuticals or functional foods with dietary benefits beyond their fundamental macronutrient content are now a major research and industrial development concept. The occurrence of dietary and lifestyle related diseases, notably type 2 diabetes, obesity, cancer, and metabolic syndrome has become a health epidemic in developed countries. Global epidemiological studies have shown that countries where seaweed is consumed on a regular basis have significantly fewer instances of obesity and dietary-related disease. This review outlines recent developments in seaweed applications for human health from …

Dmbt1 Inhibition Of Pseudomonas Aeruginosa Twitching Motility Involves Its N-Glycosylation And Cannot Be Conferred By The Scavenger Receptor Cysteine-Rich Bacteria-Binding Peptide Domain., Jianfang Li, Stephanie J Wan, Matteo M E Metruccio, Sophia Ma, Kamran Nazmi, Floris J Bikker, David J. Evans, Suzanne M J Fleiszig

Faculty Publications & Research of the TUC College of Pharmacy

The scavenging capacity of glycoprotein DMBT1 helps defend mucosal epithelia against microbes. DMBT1 binding to multiple bacterial species involves its conserved Scavenger Receptor Cysteine-Rich (SRCR) domains, localized to a 16-mer consensus sequence peptide, SRCRP2. Previously, we showed that DMBT1 bound Pseudomonas aeruginosa pili, and inhibited twitching motility, a pilus-mediated movement important for virulence. Here, we determined molecular characteristics required for twitching motility inhibition. Heat-denatured DMBT1 lost capacity to inhibit twitching motility and showed reduced pili binding (~40%). Size-exclusion chromatography of Lys-C-digested native DMBT1 showed that only high-Mw fractions retained activity, suggesting involvement of the N-terminal containing repeated SRCR domains with …

Resistance Is Futile: Rna-Sequencing Reveals Differing Responses To Bat Fungal Pathogen In Nearctic Myotis Lucifugus And Palearctic Myotis Myotis, Thomas M. Lilley, Jenni M. Prokkola, Anna S. Blomberg

KIP Articles

Resistance and tolerance allow organisms to cope with potentially life-threatening pathogens. Recently introduced pathogens initially induce resistance responses, but natural selection favors the development of tolerance, allowing for a commensal relationship to evolve. Mycosis by Pseudogymnoascus destructans, causing white-nose syndrome (WNS) in Nearctic hibernating bats, has resulted in population declines since 2006. The pathogen, which spread from Europe, has infected species of Palearctic Myotis for a longer period. We compared ecologically relevant responses to the fungal infection in the susceptible Nearctic M. lucifugus and less susceptible Palearctic M. myotis, to uncover factors contributing to survival differences in the two species. …

Related And Unrelated Donor Transplantation For Β-Thalassemia Major: Results Of An International Survey., Chunfu Li, Vikram Mathews, Soyoung Kim, Biju George, Kyle Hebert, Hua Jiang, Changgang Li, Yiping Zhu, Daniel A. Keesler, Jaap Jan Boelens, Christopher C. Dvorak, Rajni Agarwal, Jeffery J. Auletta, Rakesh K. Goyal, Rabi Hanna, Kimberly Kasow, Shalini Shenoy, Angela R. Smith, Mark C. Walters, Mary Eapen

Manuscripts, Articles, Book Chapters and Other Papers

We studied 1110 patients with β-thalassemia major aged ≤25 years who received transplants with grafts from HLA-matched related (n = 677; 61%), HLA-mismatched related (n = 78; 7%), HLA-matched unrelated (n = 252; 23%), and HLA-mismatched unrelated (n = 103; 9%) donors between 2000 and 2016. Ninety percent of transplants were performed in the last decade. Eight-five percent of patients received ≥20 transfusions and 88% were inadequately chelated. All patients received myeloablative-conditioning regimen. Overall and event-free survival were highest for patients aged ≤6 years and after HLA-matched related and HLA-matched unrelated donor transplantation. The 5-year probabilities of overall survival for …

Histological Findings In Wild Rodents Of The Great Basin, Andrew W. Bartlow

Western North American Naturalist

In the western United States, significant environmental change is expected through the combined effects of climate change, tree mortality, drought, and invasive species. Wild animals can be used as indicators of threats to populations and even entire communities by looking for histopathological changes in their tissues. This method may identify threats to wild populations quickly and more accurately than waiting to observe population declines; however, baseline data are needed for comparisons. Here, rodents are surveyed at 5 sites in the Great Basin to record histopathological changes. Additionally, one site is next to a copper mine that was in operation for …

Peptide Presentation By Bat Mhc Class I Provides New Insight Into The Antiviral Immunity Of Bats, Dan Lu, Kefang Liu, Di Zhang, Can Yue, Qiong Lu, Hao Cheng, Liang Wang, Yan Chai, Jianxun Qi, Lin-Fa Wang, George F. Gao, William J. Liu

KIP Articles

No abstract provided.