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2019

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Qualitative Analysis Of A Sir Epidemic Model With A Nonlinear Relapse And Incidence Rate Stochastically Perturbed, Abdelaziz Assadouq, Adel Settati, Ali El Myr Nov 2019

Qualitative Analysis Of A Sir Epidemic Model With A Nonlinear Relapse And Incidence Rate Stochastically Perturbed, Abdelaziz Assadouq, Adel Settati, Ali El Myr

Applied Mathematics & Information Sciences

In this paper, we analyze a stochastic SIR epidemic model in a constant population with a relapse and nonlinear perturbation. First, we illustrate show that the system has a unique global positive solution that belongs to a positively invariant set. Then, we obtain sufficient conditions for the extinction and persistence in the mean. Finally, numerical simulations are carried out to illustrate the theoretical results.

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Assessing Clinical Judgment Utilizing Embedded Patients In A Baccalaureate Nursing Program’S Simulation Laboratory, David K. Wells Nov 2019

Assessing Clinical Judgment Utilizing Embedded Patients In A Baccalaureate Nursing Program’S Simulation Laboratory, David K. Wells

All Theses And Dissertations

The purpose of this study was to determine if clinical judgment could be assessed in baccalaureate nursing students during a 15 to 20-minute embedded (live patient) simulation scenario using role play. Graduate nurses are expected to apply critical reasoning and be clinically competent when caring for patients when they enter the nursing profession. The use of simulation scenarios is an approved and effective supplement to the clinical experience of nursing students. This study was conducted due to the sparsity of evidence referencing clinical judgment in live patient simulation scenarios. This study used a convenience sample (n=22) of baccalaureate nursing students …

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The Dynamics Of Real-Time Online Information And Disease Progression: Understanding Spatial Heterogeneity In The Relationship, Blake Tindol, Utkarsh Shrivastava, Kuanchin Chen Nov 2019

The Dynamics Of Real-Time Online Information And Disease Progression: Understanding Spatial Heterogeneity In The Relationship, Blake Tindol, Utkarsh Shrivastava, Kuanchin Chen

Transactions of the International Conference on Health Information Technology Advancement

The re-emergence of infectious diseases such as measles and polio is creating logistics challenges for the state authorities to curb their spread and contain them. (CL, 2015) Real-time surveillance of infectious diseases is important to detect possible epidemics in advance to prevent shortages of medications (FDA, 2018). The outbreak of an infectious disease creates panic in the community and is accompanied by a sudden increase in the online interest in knowing more about the disease and its symptoms. Prior studies have found a strong relationship between web-based information and disease outbreak but the influence of dynamics of web-based information in …

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Microbial Profile And Antibiotic Susceptibility Trend In Postoperative Endophthalmitis: A 12-Year Review, Rashid Baig, Pushpa Bhawan Mal, Khabir Ahmed, Salman Naveed Sadiq, Sidra Zafar, Ghazala Jabeen, Saajan Kukreja Nov 2019

Microbial Profile And Antibiotic Susceptibility Trend In Postoperative Endophthalmitis: A 12-Year Review, Rashid Baig, Pushpa Bhawan Mal, Khabir Ahmed, Salman Naveed Sadiq, Sidra Zafar, Ghazala Jabeen, Saajan Kukreja

Section of Ophthalmology

Objective: To identify the microbial profile and susceptibility pattern of pathogens responsible for culture-proven postoperative endophthalmitis, and to investigate possible trends in both pathogens and antibiotic sensitivities.
Methods: The retrospective study was conducted at Aga Khan University Hospital, Karachi, and comprised record of ophthalmology patients from January 1, 2005, to December 31, 2016. Culture and sensitivity reports of vitreous and aqueous humor samples from all the patients were retrieved from the medical record section of the hospital. SPSS 19 was used for data analysis.
Results: Of the samples of 202 patients with a mean age of 58.2±15.8 years, 106(52.5%) were …

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An Investigation Into How Teachers Support Learners Reading In Grade One: A Study Of A Selected Primary School In Kenya, Kisumu County, Nyando Sub-County, Felix Okoth K'Ochuka Nov 2019

An Investigation Into How Teachers Support Learners Reading In Grade One: A Study Of A Selected Primary School In Kenya, Kisumu County, Nyando Sub-County, Felix Okoth K'Ochuka

Master of Education

Reading is very important as it helps the learners to interpret information. Its foundation in young learners enhances their understanding of other subjects as well. It is for this reason that teachers should ensure that learners in grade one are taught how to articulate words well and be in a position to read. In order for reading to be meaningful to these learners, teachers should make it real and meaningful by using relevant resources when teaching so that learners can easily master them. The objective of this study was to find out which materials teachers use in teaching reading in …

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A Baker's Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2018, Elias B. Chahine, Spencer H. Durham, Krutika N. Mediwala, Daniel B. Chastain, Timothy P. Gauthier, Brandon K. Hill, Bruce M. Jones, Jamie J. Kisgen, Ashley H. Marx, Kayla R. Stover, Marylee V. Worley, Christopher M. Bland, P Brandon Bookstaver Nov 2019

A Baker's Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2018, Elias B. Chahine, Spencer H. Durham, Krutika N. Mediwala, Daniel B. Chastain, Timothy P. Gauthier, Brandon K. Hill, Bruce M. Jones, Jamie J. Kisgen, Ashley H. Marx, Kayla R. Stover, Marylee V. Worley, Christopher M. Bland, P Brandon Bookstaver

Faculty Publications

With an increasing number of antimicrobial stewardship-related articles published each year, attempting to stay current is challenging. The Southeastern Research Group Endeavor (SERGE-45) identified antimicrobial stewardship-related peer-reviewed literature that detailed an actionable intervention for 2018. The top 13 publications were selected using a modified Delphi technique. These manuscripts were reviewed to highlight the actionable intervention used by antimicrobial stewardship programs to provide key stewardship literature for teaching and training as well as to identify potential intervention opportunities within one's institution.

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Testing Predictability Of Disease Outbreaks With A Simple Model Of Pathogen Biogeography, Tad A. Dallas, Colin J. Carlson, Timothée Poisot Nov 2019

Testing Predictability Of Disease Outbreaks With A Simple Model Of Pathogen Biogeography, Tad A. Dallas, Colin J. Carlson, Timothée Poisot

Faculty Publications

© 2019 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. Predicting disease emergence and outbreak events is a critical task for public health professionals and epidemiologists. Advances in global disease surveillance are increasingly generating datasets that are worth more than their component parts for prediction-oriented work. Here, we use a trait-free approach which leverages information on the global community of human infectious diseases to predict the biogeography of pathogens through time. Our approach takes pairwise dissimilarities between countries’ pathogen …

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Avian Ecological Succession In The Amazon: A Long-Term Case Study Following Experimental Deforestation, Cameron L. Rutt, Vitek Jirinec Nov 2019

Avian Ecological Succession In The Amazon: A Long-Term Case Study Following Experimental Deforestation, Cameron L. Rutt, Vitek Jirinec

Faculty Publications

Approximately 20% of the Brazilian Amazon has now been deforested, and the Amazon is currently experiencing the highest rates of deforestation in a decade, leading to large-scale land-use changes. Roads have consistently been implicated as drivers of ongoing Amazon deforestation and may act as corridors to facilitate species invasions. Long-term data, however, are necessary to determine how ecological succession alters avian communities following deforestation and whether established roads lead to a constant influx of new species. We used data across nearly 40 years from a large-scale deforestation experiment in the central Amazon to examine the avian colonization process in a …

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Incorporating B Cell Activating Factor (Baff) Into The Membrane Of Rabies Virus (Rabv) Particles Improves The Speed And Magnitude Of Vaccine-Induced Antibody Responses., Joseph R Plummer, James P Mcgettigan Nov 2019

Incorporating B Cell Activating Factor (Baff) Into The Membrane Of Rabies Virus (Rabv) Particles Improves The Speed And Magnitude Of Vaccine-Induced Antibody Responses., Joseph R Plummer, James P Mcgettigan

Department of Microbiology and Immunology Faculty Papers

B cell activating factor (BAFF) is a member of the tumor necrosis factor (TNF) superfamily of cytokines that links innate with adaptive immunity. BAFF signals through receptors on B cells, making it an attractive molecule to potentiate vaccine-induced B cell responses. We hypothesized that a rabies virus (RABV)-based vaccine displaying both antigen and BAFF on the surface of the same virus particle would target antigen-specific B cells for activation and improve RABV-specific antibody responses. To test this hypothesis, we constructed a recombinant RABV-based vector expressing virus membrane-anchored murine BAFF (RABV-ED51-mBAFF). BAFF was incorporated into the RABV particle and determined to …

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Multiple Cytosolic Dna Sensors Bind Plasmid Dna After Transfection, Nina Semenova, Masa Bosnjak, Katarina Znidar, Maja Cemazar, Loree Heller Nov 2019

Multiple Cytosolic Dna Sensors Bind Plasmid Dna After Transfection, Nina Semenova, Masa Bosnjak, Katarina Znidar, Maja Cemazar, Loree Heller

Bioelectrics Publications

Mammalian cells express a variety of nucleic acid sensors as one of the first lines of defense against infection. Despite extensive progress in the study of sensor signaling pathways during the last decade, the detailed mechanisms remain unclear. In our previous studies, we reported increased type I interferon expression and the upregulation of several proposed cytosolic DNA sensors after transfection of several tumor cell types with plasmid DNA (pDNA). In the present study, we sought to reveal the early events in the cytosolic sensing of this nucleic acid in a myoblast cell line. We demonstrated that DNA-dependent activator of interferon …

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Cul3 Regulates Cyclin E1 Protein Abundance Via A Degron Located Within The N-Terminal Region Of Cyclin E, Brittney Marie Davidge, Katia De Oliveira Rebola, Larry N. Agbor, Curt D. Sigmund, Jeffrey D. Singer Nov 2019

Cul3 Regulates Cyclin E1 Protein Abundance Via A Degron Located Within The N-Terminal Region Of Cyclin E, Brittney Marie Davidge, Katia De Oliveira Rebola, Larry N. Agbor, Curt D. Sigmund, Jeffrey D. Singer

Biology Faculty Publications and Presentations

mammalian cells. Increased levels of cyclin E are found in some cancers. Additionally, proteolytic removal of the cyclin E N-terminus occurs in some cancers and is associated with increased cyclin E–Cdk2 activity and poor clinical prognosis. Cyclin E levels are tightly regulated and controlled in part through ubiquitin-mediated degradation initiated by one of two E3 ligases, Cul1 and Cul3. Cul1 ubiquitylates phosphorylated cyclin E, but the mechanism through which Cul3 ubiquitylates cyclin E is poorly understood. In experiments to ascertain how Cul3 mediates cyclin E destruction, we identified a degron on cyclin E that Cul3 targets for ubiquitylation. Recognition of …

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Investigation Of Wellbeing Of Preschoolers In Shared School Environment, Hamza Shabani Nov 2019

Investigation Of Wellbeing Of Preschoolers In Shared School Environment, Hamza Shabani

Master of Education

Tanzania as a member of the international community is in the implementation of various conversion which advocates for the wellbeing of children at home and the school environment. This study investigated the wellbeing of preschoolers in a shared school environment at Kiomboi district Singida- Tanzania. The study employed a qualitative approach and case study designed in which interview, observation and document analysis were used as a tool of data collections. Two primary schools were involved in this study where respondents were two preschool teachers, one quality assurer and two heads of school were interviewed during data collection. Data revealed that …

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How Oxygen Availability Affects The Antimicrobial Efficacy Of Host Defense Peptides: Lessons Learned From Studying The Copper-Binding Peptides Piscidins 1 And 3, Adenrele Oludiran, David S. Courson, Malia D. Stuart, Anwar R. Radwan, John C. Putsma, Myriam L. Cotten, Erin B. Purcell Nov 2019

How Oxygen Availability Affects The Antimicrobial Efficacy Of Host Defense Peptides: Lessons Learned From Studying The Copper-Binding Peptides Piscidins 1 And 3, Adenrele Oludiran, David S. Courson, Malia D. Stuart, Anwar R. Radwan, John C. Putsma, Myriam L. Cotten, Erin B. Purcell

Chemistry & Biochemistry Faculty Publications

The development of new therapeutic options against Clostridioides difficile (C. difficile) infection is a critical public health concern, as the causative bacterium is highly resistant to multiple classes of antibiotics. Antimicrobial host-defense peptides (HDPs) are highly effective at simultaneously modulating the immune system function and directly killing bacteria through membrane disruption and oxidative damage. The copper-binding HDPs piscidin 1 and piscidin 3 have previously shown potent antimicrobial activity against a number of Gram-negative and Gram-positive bacterial species but have never been investigated in an anaerobic environment. Synergy between piscidins and metal ions increases bacterial killing aerobically. Here, we …

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Septic Shock And Vasopressor Therapy: The Impact Of Excessive Mean Arterial Pressure Values, Barbara Clark Mims Nov 2019

Septic Shock And Vasopressor Therapy: The Impact Of Excessive Mean Arterial Pressure Values, Barbara Clark Mims

Biennial Convention (CONV)

A retrospective, correlational, longitudinal study explores relationships between excessive mean arterial pressure values and adverse outcomes during septic shock. These include duration of vasopressor exposure, duration of mechanical ventilation, length of ICU stay, length of hospital stay, and mortality at 28 days, 90 days, and one year after hospital discharge.

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Community-Acquired Pneumonia Pathogenesis In Patients With Chronic Obstructive Pulmonary Disease, Julio A. Ramirez, Rodrigo Cavallazzi Nov 2019

Community-Acquired Pneumonia Pathogenesis In Patients With Chronic Obstructive Pulmonary Disease, Julio A. Ramirez, Rodrigo Cavallazzi

The University of Louisville Journal of Respiratory Infections

No abstract provided.

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Is There Value To Sub-Specialty Training In Sub-Saharan Africa?, Elkanah Omenge, S. E. Sinasac, Peter Itsura, Philip Tonui, B. Rosen, A. Covens Nov 2019

Is There Value To Sub-Specialty Training In Sub-Saharan Africa?, Elkanah Omenge, S. E. Sinasac, Peter Itsura, Philip Tonui, B. Rosen, A. Covens

Obstetrics and Gynaecology, East Africa

Over the past three decades, Africa has focused on combatting infectious diseases, such as tuberculosis, malaria, and HIV/ AIDS. As treatment strategies for infectious diseases have improved over time, life expectancy has increased, shifting the burden to chronic diseases, such as cancer. The WHO has now identified non-communicable diseases, including cancer, as the new epidemic in sub-Saharan Africa1. Cancer incidence and mortality are increasing rapidly in low and middle-income countries (LMIC) as compared to high-income countries. By 2020, it is predicted that 70% of all new cancers worldwide will occur in LMIC2. In 2012 850 000 new cancers were diagnosed …

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Combatting The Opioid Epidemic In Texas By Holding Big Pharma Manufacturers Liable, Katherine Spiser Nov 2019

Combatting The Opioid Epidemic In Texas By Holding Big Pharma Manufacturers Liable, Katherine Spiser

St. Mary's Law Journal

Abstract forthcoming

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Whither Extensive Genomic-Based Microbial Taxonomic Revision?, Erik Munson, Karen C. Carroll Nov 2019

Whither Extensive Genomic-Based Microbial Taxonomic Revision?, Erik Munson, Karen C. Carroll

Clinical Lab Sciences Faculty Research and Publications

No abstract provided.

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Cerebral Septic Emboli, Muhammad Affan Nov 2019

Cerebral Septic Emboli, Muhammad Affan

Detroit Stroke Conference 2019

No abstract provided.

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Twenty Novel Disease Group-Specific And 12 New Shared Macrophage Pathways In Eight Groups Of 34 Diseases Including 24 Inflammatory Organ Diseases And 10 Types Of Tumors., Bin Lai, Jiwei Wang, Alexander Fagenson, Yu Sun, Jason Saredy, Yifan Lu, Gayani Nanayakkara, William Y Yang, Daohai Yu, Ying Shao, Charles Drummer, Candice Johnson, Fatma Saaoud, Ruijing Zhang, Qian Yang, Keman Xu, Kevin Mastascusa, Ramon Cueto, Hangfei Fu, Susu Wu, Lizhe Sun, Peiqian Zhu, Xuebin Qin, Jun Yu, Daping Fan, Ying H Shen, Jianxin Sun, Thomas Rogers, Eric T Choi, Hong Wang, Xiaofeng Yang Nov 2019

Twenty Novel Disease Group-Specific And 12 New Shared Macrophage Pathways In Eight Groups Of 34 Diseases Including 24 Inflammatory Organ Diseases And 10 Types Of Tumors., Bin Lai, Jiwei Wang, Alexander Fagenson, Yu Sun, Jason Saredy, Yifan Lu, Gayani Nanayakkara, William Y Yang, Daohai Yu, Ying Shao, Charles Drummer, Candice Johnson, Fatma Saaoud, Ruijing Zhang, Qian Yang, Keman Xu, Kevin Mastascusa, Ramon Cueto, Hangfei Fu, Susu Wu, Lizhe Sun, Peiqian Zhu, Xuebin Qin, Jun Yu, Daping Fan, Ying H Shen, Jianxin Sun, Thomas Rogers, Eric T Choi, Hong Wang, Xiaofeng Yang

Center for Translational Medicine Faculty Papers

The mechanisms underlying pathophysiological regulation of tissue macrophage (Mφ) subsets remain poorly understood. From the expression of 207 Mφ genes comprising 31 markers for 10 subsets, 45 transcription factors (TFs), 56 immunometabolism enzymes, 23 trained immunity (innate immune memory) enzymes, and 52 other genes in microarray data, we made the following findings. (1) When 34 inflammation diseases and tumor types were grouped into eight categories, there was differential expression of the 31 Mφ markers and 45 Mφ TFs, highlighted by 12 shared and 20 group-specific disease pathways. (2) Mφ in lung, liver, spleen, and intestine (LLSI-Mφ) express higher M1 Mφ …

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An Update On Pharmaceutical Strategies For Oral Delivery Of Therapeutic Peptides And Proteins, Nirnoy Dan Nov 2019

An Update On Pharmaceutical Strategies For Oral Delivery Of Therapeutic Peptides And Proteins, Nirnoy Dan

Theses and Dissertations (ETD)

Peptides and proteins are imperative for the human body and play crucial roles in governing various bio-chemical processes. Recent advances in molecular biology and biochemistry helped in understanding the role of these endogenous macromolecules in different pathological and disease conditions. Currently, small molecule drugs (< 900dalton) in comparison to the therapeutic peptides and proteins-based drugs (TPP) dominate pharmaceutical market. However, the game is changing with the recent advances of biotechnological tools like recombinant DNA technology, solid phase protein synthesis etc., which enabled large-scale production of therapeutic peptides and proteins. The Success of Human Insulin, the first FDA approved commercial recombinant protein based therapeutic in 1982, revolutionized the field of TPPs. The number of FDA approved TPPs reached about to ~239 in 2017 compared to where it was only ~130 in 2008. Rapid progress in this sector can be attributed to several advantages of proteins and peptides over small molecule drugs both financially and clinically. From a clinical perspective, proteins and peptides are inherently more specific to the target site than the small molecules drugs, which lead to less interferences with normal biological system of the patient and caused minimal off-target side effects. A handful of proteins which are used for different clinical complications are less immunogenic because they are produced in the body naturally. Furthermore, proteins and peptides also take part in several complex and complicated biological processes, which is difficult to be to be mimicked by the small molecule drugs. From a financial standpoint, median total pre-market development times were shorter for biologics (10.6 years) than the small molecules drugs (12.6 years) estimated using Merck Index. In 2009, US Congress passed the Biologics Price Competition and Innovation Act (BPCIA) which gave new biologics 12 years of guaranteed exclusivity. The most commonly utilized routes for administering TPPs are I.V, I.P or I.M injections, which largely suffer from patient compliances. There are ~350 TPPs under clinical development and among them only 2 are given orally which is Interferon-α and Human growth hormone. Currently, most efforts in both industry and academia are centered around enhancing bioavailability of orally administered TPPs which typically are less than 1%. Oral administration is the non-invasive, most preferred route of drug administration for the patients. Furthermore, oral dosage forms are cheaper to manufacture as well as to administer, because they do not need to be produced under sterile conditions or administered in clinics. However, unfavorable physicochemical characteristics of TPPs like high molecular weight, hydrophilicity, poor stability in the physiological conditions, short biological half-life, low permeability through the epithelial barrier in the small intestine put up a massive barrier in the development of orally available dosage forms of TPPs. In this review, we will discuss the challenges associated with oral delivery of TPPs and the ongoing efforts to solve them.

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A Matched Case-Control Study To Assess The Carbapenem-Resistant Enterobacteriaceae Infections Among Hospitalized Children At King Fahad Medical City, Riyadh, Saudi Arabia, Omar A. Alzomor, Tariq S. Alfawaz, Amani Abu-Shaheen, Mohammed A. Alshehri, Dayel Al Shahrani Nov 2019

A Matched Case-Control Study To Assess The Carbapenem-Resistant Enterobacteriaceae Infections Among Hospitalized Children At King Fahad Medical City, Riyadh, Saudi Arabia, Omar A. Alzomor, Tariq S. Alfawaz, Amani Abu-Shaheen, Mohammed A. Alshehri, Dayel Al Shahrani

Saudi Medical Journal

Objectives: To identify risk factors associated with carbapenem-resistant Enterobacteriaceae (CRE) infections among hospitalized children at King Fahad Medical City, Riyadh, Saudi Arabia. Methods: A retrospective matched case-control study was conducted in pediatric patients with CRE infection at King Fahad Medical City, Riyadh, Saudi Arabia between January 2016-2017. Results: During the study period, 19 CRE cases and 37 controls were identified for analysis. Children ≤17 years (mean age±SD for cases was 43.9±46 months and controls was 29.2±52.2 months) were included in the study. Several factors associated with CRE infections were identified, which included, central venous catheter (CVC) line placement ( p …

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Analysis Of Drug Resistance Of Extended-Spectrum Beta-Lactamases-Producing Escherichia Coli And Klebsiella Pneumoniae In Children With Urinary Tract Infection, Lu Keshi, Xiao Weiwei, Li Shoulin, Liu Xiaodong, Wang Hao, Jiang Junhai, Wang Xiangwei, Wang Rui, Zhu Pei Nov 2019

Analysis Of Drug Resistance Of Extended-Spectrum Beta-Lactamases-Producing Escherichia Coli And Klebsiella Pneumoniae In Children With Urinary Tract Infection, Lu Keshi, Xiao Weiwei, Li Shoulin, Liu Xiaodong, Wang Hao, Jiang Junhai, Wang Xiangwei, Wang Rui, Zhu Pei

Saudi Medical Journal

Objectives: To investigate the drug resistance of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli ( E. coli ) and Klebsiella pneumoniae (K.pneumoniae) in children with urinary tract infection (UTI) and to provide the rationale for clinical use of antibiotics. Methods: This is a retrospective analysis of drug susceptibility in children with E. coli or K. pneumoniae -positive urine culture between August 2013 and August 2017, Shenzhen Children’s Hospital, Shenzhen, China. Drug resistance was statistically assessed using Fisher exact test and χ 2 test. Results: A total of 698 cases of E. coli , 426 of which were confirmed ESBL-producing strains, and 217 …

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Medtruth: A Semi-Supervised Approach To Discovering Knowledge Condition Information From Multi-Source Medical Data, Yang Deng, Yaliang Li, Ying Shen, Nan Du, Wei Fan, Min Yang, Kai Lei Nov 2019

Medtruth: A Semi-Supervised Approach To Discovering Knowledge Condition Information From Multi-Source Medical Data, Yang Deng, Yaliang Li, Ying Shen, Nan Du, Wei Fan, Min Yang, Kai Lei

Research Collection School Of Computing and Information Systems

Knowledge Graph (KG) contains entities and the relations between entities. Due to its representation ability, KG has been successfully applied to support many medical/healthcare tasks. However, in the medical domain, knowledge holds under certain conditions. Such conditions for medical knowledge are crucial for decisionmaking in various medical applications, which is missing in existing medical KGs. In this paper, we aim to discovery medical knowledge conditions from texts to enrich KGs. Electronic Medical Records (EMRs) are systematized collection of clinical data and contain detailed information about patients, thus EMRs can be a good resource to discover medical knowledge conditions. Unfortunately, the …

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Professional Competency Development Utilizing Emotional Intelligence In Medical Programs, Christopher Carlin Nov 2019

Professional Competency Development Utilizing Emotional Intelligence In Medical Programs, Christopher Carlin

All Theses And Dissertations

The purpose of this mixed methods study was to examine the perceptions of physician assistant faculty about emotional intelligence. The study sought to determine PA educators’ familiarity with EI as a construct and to elicit perceived barriers in implementing EI within PA educational programs. The data were collected from a both a focus group of physician assistant faculty was convened from a university in New England and an online cross-sectional survey of randomized physician assistant faculty throughout the United States. The quantitative portion of the research investigated the perceptions faculty held about emotional intelligence. Additionally, the survey asked participants to …

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Innovative Business Model For Smart Healthcare Insurance, Maryam Hasan Al Thawadi Nov 2019

Innovative Business Model For Smart Healthcare Insurance, Maryam Hasan Al Thawadi

Information Security Theses

Information revolution and technology growth have made a considerable contribution to restraining the cost expansion and empowering the customer. They disrupted most business models in different industries. The customer-centric business model has pervaded the different sectors. Smart healthcare has made an enormous shift in patient life and raised their expectations of healthcare services quality. Healthcare insurance is an essential business in the healthcare sector; patients expect a new business model to meet their needs and enhance their wellness. This research develops a holistic smart healthcare architecture based on the recent development of information and communications technology. Then develops a disruptive …

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Human Monoclonal Antibodies Against Chikungunya Virus Target Multiple Distinct Epitopes In The E1 And E2 Glycoproteins, Jose A. Quiroz, Ryan J. Malonis, Larissa B. Thackray, Courtney A. Cohen, Jesper Pallesen, Rohit K. Jangra, Rebecca S. Brown, Daniel Hofmann, Frederick W. Holtsberg, Sergey Shulenin, Elisabeth K. Nyakatura, Lorellin A. Durnell, Vinayak Rayannavar, Johanna P. Daily, Andrew B. Ward, M. Javad Aman, John M. Dye, Kartik Chandran, Michael S. Diamond, Margaret Kielian, Jonathan R. Lai Nov 2019

Human Monoclonal Antibodies Against Chikungunya Virus Target Multiple Distinct Epitopes In The E1 And E2 Glycoproteins, Jose A. Quiroz, Ryan J. Malonis, Larissa B. Thackray, Courtney A. Cohen, Jesper Pallesen, Rohit K. Jangra, Rebecca S. Brown, Daniel Hofmann, Frederick W. Holtsberg, Sergey Shulenin, Elisabeth K. Nyakatura, Lorellin A. Durnell, Vinayak Rayannavar, Johanna P. Daily, Andrew B. Ward, M. Javad Aman, John M. Dye, Kartik Chandran, Michael S. Diamond, Margaret Kielian, Jonathan R. Lai

Open Access Publications

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes persistent arthritis in a subset of human patients. We report the isolation and functional characterization of monoclonal antibodies (mAbs) from two patients infected with CHIKV in the Dominican Republic. Single B cell sorting yielded a panel of 46 human mAbs of diverse germline lineages that targeted epitopes within the E1 or E2 glycoproteins. MAbs that recognized either E1 or E2 proteins exhibited neutralizing activity. Viral escape mutations localized the binding epitopes for two E1 mAbs to sites within domain I or the linker between domains I and III; and for two …

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Time To Adopt Developmental Origins Of Health And Disease (Dohad) Science In Pakistan, Rozina Nuruddin, Akbar Shoukat Ali, Nuruddin Badruddin Mohammed Nov 2019

Time To Adopt Developmental Origins Of Health And Disease (Dohad) Science In Pakistan, Rozina Nuruddin, Akbar Shoukat Ali, Nuruddin Badruddin Mohammed

Community Health Sciences

No abstract provided.

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Plasma Cysteine/Cystine And Glutathione/Glutathione Disulfide Redox Potentials In Hiv And Copd Patients., Walter H. Watson, Jeffrey D. Ritzenthaler, Paula Peyrani, Timothy L. Wiemken, Stephen P. Furmanek, Andrea Reyes-Vega, Tom J. Burke, Yuxuan Zheng, Julio A. Ramirez, Jesse Roman Nov 2019

Plasma Cysteine/Cystine And Glutathione/Glutathione Disulfide Redox Potentials In Hiv And Copd Patients., Walter H. Watson, Jeffrey D. Ritzenthaler, Paula Peyrani, Timothy L. Wiemken, Stephen P. Furmanek, Andrea Reyes-Vega, Tom J. Burke, Yuxuan Zheng, Julio A. Ramirez, Jesse Roman

Faculty and Staff Scholarship

Chronic obstructive pulmonary disease (COPD) is prevalent in patients infected with HIV. The purpose of this study was to test the hypothesis that systemic oxidation correlates with loss of lung function in subjects with COPD, and that HIV infection can contribute to creating such an environment. Subjects were recruited at the University of Louisville in the following groups: HIV-infected (n = 36), COPD (n = 32), HIV and COPD (n = 28), and uninfected controls with normal lung function (n = 34). HIV infection was assessed by viral load and CD4 cell counts. Pulmonary function was determined by spirometry …

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Analysis Of Genetic Variation Of Western And Eastern Populations Of Socotra Cormorant (Phalacrocorax Nigrogularis) In The Uae, Salama Rashed Al Mansouri Nov 2019

Analysis Of Genetic Variation Of Western And Eastern Populations Of Socotra Cormorant (Phalacrocorax Nigrogularis) In The Uae, Salama Rashed Al Mansouri

Biology Theses

Understanding the genetic structure of threatened and endangered species is important in management and conservation efforts. Measuring the pattern and scale of genetic variation within and among populations is important for understanding population dynamics. It helps us improve our understanding of the ecological and genetic relation between the populations. The current research looks at the population structure of the endemic seabird of the United Arab Emirates (UAE), the Socotra cormorant (Phalacrocorax nigrogularis). The lack of genetic information, increased threats, and small breeding habitats of the Socotra cormorants, makes it important to investigate the genetic population structure in the …

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