Storm On The Horizon: Climate Change, Hurricanes, And The Future Of The Eastern Caribbean, Joseph P. Odegaard

Student Theses 2015-Present

Hurricanes are a fact of life in the Caribbean. This meteorological reality has shaped the islands’ development throughout its history. However, in recent years, the Atlantic’s most fearsome storms have been unprecedented, both in strength and number. This paper explores the relationship between climate change and hurricanes and the effect this relationship has on the Eastern Caribbean. Chapter 1 uses quantitative data from a variety of sources, including the Intergovernmental Panel on Climate Change and the Millennium Ecosystem Assessment of the United Nations, as well as the National Oceanic and Atmospheric Association and the National Climate Assessment of the United …

Fighting Food Insecurity For Nyc Children And Youth: Urban Agriculture And Food Justice, Devin C. O'Mara

Student Theses 2015-Present

The positive benefits of urban agriculture go beyond just providing fresh and healthy food to metropolitan areas. As the practice of urban farming has become increasingly more popular over the last decade or so, it has proven to develop community relations and aide with metropolitan and global issues such as poverty. Children and teens especially benefit from urban agriculture, specifically those that comes from underprivileged homes that may not have the resources to obtain fresh food every day. A shocking number of kids can go hungry every day due to lack of available food. Many children that live in metropolitan …

Transcription Regulation Of Human Il1b Gene In Monocytes And Lymphoid Cd4 T Cells, Sree H. Pulugulla

Electronic Theses and Dissertations

Cytokines are key regulators of the inflammatory response and play an important role in facilitating intercellular communication between various immune cell types. Interleukin‑1β (IL‑1β) is a potent pro-inflammatory cytokine that is required for robust initiation of innate immune response and subsequent development of adaptive immunity. IL-1β is first synthesized as an inactive cytoplasmic, non‑glycosylated, precursor molecule (proIL‑1β) by monocytes and macrophages in response to invading pathogenic microbes. The activation of caspase‑1 by inflammasomes cleaves proIL-1β into mature biologically active IL-1β that is released from cells via a non-classical, endoplasmic reticulum‑independent secretory pathway directly from the cytoplasm via Gasdermin D membrane …

Synthesis And Characterization Of Long Acting Darunavir Prodrugs, Mary Banoub

Theses & Dissertations

Patient adherence is critical for ART success to ensure adequate viral suppression, therefore, long-acting antiretrovirals are soon replacing current daily regimens. In recent years, two drugs were successfully transformed into long-acting injectables; CAB LA and RPV LA. These long-acting nanoformulations made it possible to abandon the daily pill burden, instead approximately a bimonthly injection of both drugs is enough to suppress and maintain viral load suppression. Our laboratory has been instrumental in transforming FDA-approved and experimental-HIV medications into long-acting slow effective release drugs, also known as LASER ART. LASER ART consists of slow drug metabolism and high permeability and retention …

Enhancing The Identification Of Rheumatoid Arthritis-Associated Lung Disease, Bryant England

Theses & Dissertations

Rheumatoid arthritis (RA) is a systemic autoimmune disease that predisposes afflicted individuals to reduced quality of life, physical disability, and premature mortality. While joint involvement is the primary manifestation of RA, extra-articular features including lung disease are responsible for a significant portion of the excess mortality. In this dissertation I demonstrate the contribution of chronic lung diseases to premature mortality in RA, contrasting with the more widely recognized comorbidity in RA of cardiovascular disease. Then, I establish that a novel serum biomarker, anti-malondialdehyde-acetaldehyde adduct (MAA) antibody, is associated with the presence of interstitial lung disease (ILD) in RA subjects. Further …

Engineering Hyaluronic Acid For Biomedical Applications, Deep S. Bhattacharya

Theses & Dissertations

This work presents research using the naturally available non- sulfated carbohydrate glycosaminoglycan hyaluronic acid (HA) for the synthesis of different chemical derivatives of HA for evaluation of binding kinetics with CD44 and P- selectin proteins for applications in fluorescence image-guided surgery. Chemical derivatives of HA such as deacetylated HA (deHA), sulfated HA (sHA), and deacetylated and sulfated HA (s-deHA) were synthesized by modulating sulfating and deacetylating reagents to alter binding specificities to CD44. Modified HA derivatives and CD44 biophysical interactions were assessed by fluorescence polarization. In silico techniques were also used to determine binding using molecular docking and MM-PBSA approaches. …

Theranostics For Antiretroviral Biodistribution And Pharmacokinetics, Brendan M. Ottemann

Theses & Dissertations

RATIONALE: Our laboratories birthed the field of human immunodeficiency virus (HIV) theranostics. The new field allows simultaneous detection (diagnostics) and treatment (therapeutic) for the identification, treatment and inevitable elimination of virus in cell and tissue compartments. By employing theranostics, antiretroviral drugs (ARVs) can be tracked in lymph nodes, gut, spleen and liver. Cellular viral reservoirs including CD4+ T cell populations and mononuclear phagocytes (MP; monocytes, macrophages, microglia and dendritic cells) along with subcellular endosomal structures can now be targeted for drug delivery bringing therapeutics to areas where virus replicates. The overarching idea rests in improving precision targeted ARV delivery. …

Role Of Astrocyte-Derived Extracellular Vesicles In Neuroinflammation Mediated By Drug Abuse, Ke Liao

Theses & Dissertations

Neuronal damage and neuroinflammation is a hallmark feature of HIV-associated neurological disorders (HANDs). Opioids abuse accelerates the incidence and progression of HAND; however, the mechanisms underlying the potentiation of neuropathogenesis by these drugs remain elusive. Extracellular vesicles (EVs) are essential conduits in HIV and drug abuse-mediated synaptodendritic injury and neuroinflammation. Findings from our group have demonstrated that astrocyte-derived EV (ADEV)-miRNA-29b mediates HIV Tat and morphine-induced neuronal injury, thus underscoring the importance of such interactions in NeuroHIV.

Besides, HIV Tat and morphine-mediated synaptodendritic injury via ADEVs, we are also interested in whether ADEVs contributes to neuroinflammation. Microglia are critical players in …

Identification Of More Potent And Efficacious Analogs Of The Novel Host-Derived Immunostimulant Ep67, Abdul Alshammari

Theses & Dissertations

EP67 is a human C5a-derived decapeptide agonist of C5a Receptor 1 (C5aR1/CD88) that selectively activates mononuclear phagocytes over neutrophils to stimulate protective innate and adaptive immune responses while potentially minimizing neutrophil-mediated toxicity. Two N-alkyl amino acids Pro⁷ and N-methyl-Leu⁸ (nme-Leu⁸) within EP67 induce structural changes that increase potency and selective activation of mononuclear phagocytes over neutrophils. Cis/trans isomerization at these positions, however, likely limits the activity of EP67 and low coupling efficiency between Pro⁷ and nme-Leu⁸ increases scale-up costs for clinical use. Thus, the goals of this study were to …

Determining Levers Of Cost-Effectiveness For Screening Infants At High Risk For Peanut Sensitization Before Early Peanut Introduction, Matthew Greenhawt, Marcus Shaker

Dartmouth Scholarship

Importance Early peanut introduction reduces the risk of developing peanut allergy, especially in high-risk infants. Current US recommendations endorse screening but are not cost-effective relative to other international strategies.

Objective To identify scenarios in which current early peanut introduction guidelines would be cost-effective.

Design, Setting, and Participants This simulation/cohort economic evaluation used microsimulations and cohort analyses in a Markov model to evaluate the cost-effectiveness of early peanut introduction with and without peanut skin prick test (SPT) screening in high-risk infants during an 80-year horizon from a societal perspective. Data were analyzed from April to May 2019.

Exposures High-risk infants with …

The Effects Of Health Beliefs, Acculturation, And A Culturally Appropriate Teaching Intervention On Parents' Knowledge Of And Compliance With Tuberculosis Treatment In A Mexican-American Population: A Preliminary Analysis, Renee P. Mcleod

Dissertations

The primary purpose of this research study, using a correlational and comparative descriptive design, was to examine the effects of health beliefs, acculturation, and a culturally appropriate Spanish-language audiotaped novena on knowledge of Tuberculosis (TB), and compliance with treatment and medications in Mexican-American parents' of a child with TB infection. Due to the limited number of subjects obtained (N = 31), the research data and analyses are presented as preliminary findings since meaningful hypothesis testing would be premature at this time.

A Mathematical Model Of Regulatory Mechanisms Of Hepatocytes And Hepatitis B, Mahruy Saidalieva, Mohiniso Baxromovna Hidirova, Abrorjon Makhamatsolievich Turgunov

Makara Journal of Science

The study of the functioning of hepatitis B viruses in liver cells using methods of mathematical modeling is considered one of today’s pressing issues. In this article, the domains of functional- differential equations in a mathematical model of regulatory mechanisms of hepatocytes interacting with hepatitis B viruses (HBV) are presented. Characteristic molecular genetic systems regulatory mechanisms of the interrelated activities of liver cells and HBV are analyzed. A series of computational experiments show that the “chaos” and “black hole” theories describe two of the more dangerous regimes. As a result of the analysis of the “chaos” regime, small regions with …

Usage Statistics: Project Counter R4 Journal Report 1 (Jr1) 2018-2019, Andree Rathemacher

Technical Services Reports and Statistics

Project COUNTER R4 Journal Report 1 (JR1) for the University of Rhode Island for the period from July 1, 2018 - June 30, 2019. Journal Report 1 is defined as "Number of Successful Full-Text Article Requests by Month and Journal." This report presents an annual total only.

File for download is Excel spreadsheet generated by Alma Analytics.

Results: 1,055,792 successful full-text article requests for 30,329 reported titles.

Migration To The Us Among Rural Puerto Ricans Who Inject Drugs: Influential Factors, Sources Of Support, And Challenges For Harm Reduction Interventions, Roberto Abadie, Patrick Habecker, C. Gelpi-Acosta, Kirk Dombrowski

Department of Sociology: Faculty Publications

Background: While PWID of Puerto Rican origin have been migrating to the US for decades, the range of factors influencing their migration to the US and the resources they draw on to do so are not well understood. This is particularly true for rural Puerto Rican PWID, and the present study is the first empirical research to document migration patterns among this population. The specificities of their migration raise important challenges that need to be documented in order to implement more effective harm reduction policies at home (Puerto Rico) and abroad (US).

Methods: This paper draws from data obtained employing …

Design Of An Enhanced Public Health Surveillance System For Hepatitis C Virus Elimination In King County, Washington, Atar Baer, Meaghan S. Fagalde, Curtis D. Drake, Elisabeth H. Sohlberg, Elizabeth Barash, Sara Glick, Alexander J. Millman, Jeffrey S. Duchin

Project ECHO Bibliography

Introduction:

With the goal of eliminating hepatitis C virus (HCV) as a public health problem in Washington State, Public Health–Seattle & King County (PHSKC) designed a Hepatitis C Virus Test and Cure (HCV-TAC) data system to integrate surveillance, clinical, and laboratory data into a comprehensive database. The intent of the system was to promote identification, treatment, and cure of HCV-infected persons (ie, HCV care cascade) using a population health approach.

Materials and Methods:

The data system automatically integrated case reports received via telephone and fax from health care providers and laboratories, hepatitis test results reported via electronic laboratory reporting, and …

Print Journal Analysis And Journal Removal Projects, Robyn M Gleasner

Projects

The Health Sciences Library and Informatics Center's main objectives were:

• To analyze the print journal holdings to determine which titles should be retained, donated, or discarded.
• To develop a plan for retaining, removing, and consolidating selected material on both the 3rd floor of the library and in offsite storage in HSSB.

A Model For The Prediction Of Antimicrobial Resistance In Escherichia Coli Based On A Comparative Evaluation Of Fatty Acid Profiles, Randal S. Stahl, Bledar Bisha, Sebabrata Mahapatra, Jeffrey C. Chandler

United States Department of Agriculture Wildlife Services: Staff Publications

Antimicrobial resistance is a threat to agricultural production and public health. In this proof-of-concept study, we investigated predicting antimicrobial sensitive/resistant (S/R) phenotypes and host sources of Escherichia coli (n = 128) based on differential fatty acid abundance. Myristic (14:0), pentadecanoic acid (15:0), palmitic (16:0), elaidic (18:19) and steric acid (18:0) were significantly different (α = 0.05) using a two-way ANOVA for predicting nalidixic acid, ciprofloxacin, aztreonam, cefatoxime, and ceftazidime S/R phenotypes. Additionally, analyses of palmitoleic (16:1), palmitic acid (16:0), methyl palmitate (i-17:0), and cis-9,10-methyleneoctadecanoic acid (19:0Δ) showed these markers were significantly different (α = 0.05) between isolates obtained from cattle …

Constraint And Trade-Offs Regulate Energy Expenditure During Childhood, Samuel S. Urlacher, J. Josh Snodgrass, Lara R. Dugas, Lawrence S. Sugiyama, Melissa A. Liebert

Biostatistics Collaborative Core: Faculty Publications and Other Works

Children’s metabolic energy expenditure is central to evolutionary and epidemiological frameworks for understanding variation in human phenotype and health. Nonetheless, the impact of a physically active lifestyle and heavy burden of infectious disease on child metabolism remains unclear. Using energetic, activity, and biomarker measures, we show that Shuar forager-horticulturalist children of Amazonian Ecuador are ~25% more physically active and, in association with immune activity, have ~20% greater resting energy expenditure than children from industrial populations. Despite these differences, Shuar children’s total daily energy expenditure, measured using doubly labeled water, is indistinguishable from industrialized counterparts. Trade-offs in energy allocation between competing …

The Dissemination Of Multidrug Resistance (Mdr) And Extensively Drug Resistant (Xdr) Among Uropathogenic E. Coli (Upec) Isolates From Urinary Tract Infection Patients In Babylon Province, Iraq, Huda Hadi Al-Hasnawy, Mohammad Ridha Judi, Hiba Jasim Hamza

Baghdad Science Journal

Antibiotic resistance is a problem of deep scientific concern both in hospital and community settings. Rapid detection in clinical laboratories is essential for the judicious recognition of antimicrobial resistant organisms. So, the growth of Uropathgenic Escherichia coli (UPEC) isolates with Multidrug-resistant (MDR) and Extensively Drug-resistant (XDR) profiles that thwart therapy for (UTIs) has been detected and has straight squeezed costs and extended hospital stays. This study aims to detect MDR- and XDR-UPEC isolates. Out of 42 UPEC clinical isolates were composed from UTI patients. The bacterial strains were recognized by standard laboratory protocols. Susceptibility to antibiotic was measured by the …

Week Of December 16, 2019, New York Medical College

InTouch

• General Dental Practice Residents and M.P.H. Candidates Complete Federal Service Internship
• Department of Public Health Hosts Annual Student Appreciation Night

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern: Reports on Ethics of Parental Refusal to Vaccinate
• Georgia Southern: Reports on Ethical Approaches to Mandating Influenza Vaccinations for Local Health Department Workforce in Georgia

Two Algorithms For The Reorganisation Of The Problem List By Organ System, Daniel B. Hier, Joshua Pearson

Chemistry Faculty Research & Creative Works

Objective Long Problem Lists Can Be Challenging to Use. Reorganization of the Problem List by Organ System is a Strategy for Making Long Problem Lists More Manageable. Methods in a Small-Town Primary Care Setting, We Examined 4950 Unique Problem Lists over 5 Years (24 033 Total Problems and 2170 Unique Problems) from Our Electronic Health Record. All Problems Were Mapped to the International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) and SNOMED CT Codes. We Developed Two Different Algorithms for Reorganizing the Problem List by Organ System based on Either the ICD-10-CM or the SNOMED CT Code. Results the …

Medical School Watercooler Newsletter - December 15, 2019, Lindsey Lyle

Watercooler Newsletter

This is the December 15, 2019 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Register Now: Pediatric Symposium set for Jan. 17

USA College of Medicine teams up with Yale on mosquito research

Barrington receives grant to develop data on rare lung disease

A Story Of Two Videos Plus Coda: Perspectives On "Contact" In Western Amazonia, Giancarlo Rolando

Tipití: Journal of the Society for the Anthropology of Lowland South America

In 2014, the Xinane people of Brazilian Amazonia made international news after two videos showing scenes of their “first contact” were uploaded to the internet. This paper explores the ways in which different audiences reacted to news about this “first contact.” Local Peruvian and Brazilian settlers, the international public, and the Mastanawa, a people culturally proximate to the Xinane, had different readings of this event and expressed opposing views concerning what actions should have been taken following the events depicted in the videos. These differences in opinion are telling of the different ways in which each group thinks of “isolated …

A Community Of Care: Patterns Of Pathology And Trauma With A Focus On The Bioarchaeology Of Care At Carrier Mills, Il (10,000 – 1000 Bp), Alecia Schrenk

UNLV Theses, Dissertations, Professional Papers, and Capstones

Illness and injury are universal human experiences which are endowed with cultural meaning. Bioarchaeology has only recently begun to engage with the socioeconomic impacts of illness, injury, impairment, and healthcare provisioning in the past. This study examines how the Middle Archaic (6000 – 300 BC) and Early Woodland (1000 – 200 BC) hunter-gatherer community of Carrier Mills, Illinois was affected by and managed the socioeconomic burdens of poor health. The data presented in this study used bioarchaeological analyses to reveal patterns of poor health and healthcare provisioning within the Carrier Mills community. Bioarchaeology is ideally situated for such investigations since …

Why Won't This Heal?: Actinomyces And Wounds, Christina Wagener

Doctor of Nursing Practice Projects

Why Won’t This heal? Actinomyces and Wounds

Christina Wagener, MSN, Steve Kalish, MD, Mary Lee Barron, PhD, APRN, FNP-BC, FAANP

An incidental finding of Actinomyces europaeus in a refractory healing abscess presents an opportunity to close a knowledge and treatment gap. After finding Actinomyces species in multiple patients within a twenty-month period in an independent hospital in Chicago, IL, the probability exists that Actinomyces is becoming more prevalent in subcutaneous wounds. Chronic, non-healing wounds cause multiple negative consequences including financial, psychological and physical losses and possibly death.

Actinomyces is a Gram-positive, filamentous, non-acid-fast and anaerobic-to-microaerophilic bacteria first identified in 1997 …

Clearance Of Chikungunya Virus Infection In Lymphoid Tissues Is Promoted By Treatment With An Agonistic Anti-Cd137 Antibody, Jun P Hong, Mary K Mccarthy, Bennett J Davenport, Thomas E Morrison, Michael S Diamond

Open Access Publications

CD137, a member of the tumor necrosis factor receptor superfamily of cell surface proteins, acts as a costimulatory receptor on T cells, natural killer cells, B cell subsets, and some dendritic cells. Agonistic anti-CD137 monoclonal antibody (MAb) therapy has been combined with other chemotherapeutic agents in human cancer trials. Based on its ability to promote tumor clearance, we hypothesized that anti-CD137 MAb might activate immune responses and resolve chronic viral infections. We evaluated anti-CD137 MAb therapy in a mouse infection model of chikungunya virus (CHIKV), an alphavirus that causes chronic polyarthritis in humans and is associated with reservoirs of CHIKV …

Infection Control: The Nurse's Responsibility, Marisa Francis

UNLV Theses, Dissertations, Professional Papers, and Capstones

Over the last century and a half, infection control measures implemented by nursing staff have continued to evolve, resulting in improved patient outcomes. While this progress is impressive, a decline in rates of hospital acquired infections (HAIs) seems to have slowed, with only a 0.5% decrease in the last seventeen years. Unfortunately, nurses are rarely provided educational support on infection control practices beyond undergraduate and new employee trainings. Meanwhile, the Centers for Disease Control (CDC) is frequently updating their infection control practice recommendations.

The purpose of this project was to observe the current rate of infection control compliance by nurses, …

Sideromycin Pathway Elucidation: Insights Into Salmycin Biosynthesis, Transport Paradigms, And Drug Release, Gerry Sann Macaraeg Rivera

Arts & Sciences Graduate Student Theses and Dissertations

Antibiotic resistance is an increasing threat in today’s society. In order to overcome resistant bacteria, it is necessary to discover new drugs with novel mechanisms of action. This work focuses on the sideromycin pathway, encompassing the biosynthetic production, mechanism of entry and hydrolysis-mediated drug release. Sideromycins are an interesting approach to combat the rise of antibiotic resistance since they provide a different avenue that overcomes problems that arise when entering the cell. The dissertation is separated into distinct sections dealing with the various areas of interest in the sideromycin pathway, particularly for the sideromycin, salmycin, produced by Streptomyces violaceus. The …

Generation And Utilization Of Diverse Memory B Cells After Flavivirus Challenges, Rachel Wong

Arts & Sciences Graduate Student Theses and Dissertations

Over the course of an effective immune response to an infection, two distinct B cell populations are generated to provide protection against reinfection, long-lived plasma cells (LLPCs) and memory B cells (MBCs). LLPCs and MBCs originate from germinal center (GC) B cells that have undergone B cell receptor (BCR) affinity maturation through iterative rounds of somatic hypermutation, proliferation, and selection. Thus, LLPCs and MBCs can bind to their antigen with higher affinity than their naïve B cell precursors. LLPCs constitutively secrete antibodies and can provide sterilizing immunity that pre-exists subsequent infections. MBCs, on the other hand, are quiescent and provide …