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Adaptation Of Translational Machinery In Malaria Parasites To Accommodate Translation Of Poly-Adenosine Stretches Throughout Its Life Cycle, Jessey Erath, Sergej Djuranovic, Slavica Pavlovic Djuranovic

Open Access Publications

Malaria is caused by unicellular apicomplexan parasites of the genus

Novel Amphiphilic Cyclobutene And Cyclobutane Cis-C18 Fatty Acid Derivatives Inhibit Mycobacterium Avium Subsp. Paratuberculosis Growth, Denise K. Zinniel, Wantanee Sittiwong, Darrell D. Marshall, Govardhan Rathnaiah, Isin T. Sakallioglu, Robert Powers, Patrick H. Dussault, Raul G. Barletta

School of Veterinary and Biomedical Sciences: Faculty Publications

Mycobacterium avium subspecies paratuberculosis (Map) is the etiologic agent of Johne’s disease in ruminants and has been associated with Crohn’s disease in humans. An effective control of Map by either vaccines or chemoprophylaxis is a paramount need for veterinary and possibly human medicine. Given the importance of fatty acids in the biosynthesis of mycolic acids and the mycobacterial cell wall, we tested novel amphiphilic C₁₀ and C₁₈ cyclobutene and cyclobutane fatty acid derivatives for Map inhibition. Microdilution minimal inhibitory concentrations (MIC) with 5 or 7 week endpoints were measured in Middlebrook 7H9 base broth media. We compared the …

Investigation Of Congestive Heart Failure In Beef Cattle In A Feedyard At A Moderate Altitude In Western Nebraska, Rodney A. Moxley, David R. Smith, Dale M. Grotelueschen, Tom Edwards, David Steffen

School of Veterinary and Biomedical Sciences: Faculty Publications

Right-sided congestive heart failure (brisket disease) commonly occurs in cattle raised at elevations >2,500– 3,500 m. We investigated clinical cases resembling brisket disease at a western Nebraska feedyard at a moderate altitude (1,369 m). Over a 15-mo period (2009–2010), we examined 17 cases (16 steers and 1 heifer), all purebred Angus. All animals had clinical right-sided heart failure: brisket and ventral abdominal edema, and severe chronic passive congestion of the liver. Gross examination confirmed right ventricular hypertrophy (left ventricle plus septum: right ventricle weight ratio mean: 1.33 vs. 2.8–4.0 reference interval). Microscopically, all 17 cases had interstitial fibrosis (mean score: …

Thymic Expression Of Il-4 And Il-15 After Systemic Inflammatory Or Infectious Th1 Disease Processes Induce The Acquisition Of"Innate" Characteristics During Cd8 + T Cell Development, Natalia S. Baez, Fabio Cerbán, Constanza Savid-Frontera, Deborah L. Hodge, Jimena Tosello, Eva Acosta-Rodriguez, Laura Almada, Adriana Gruppi, Maria Estefania Viano, Howard A. Young, Maria Cecilia Rodriguez-Galan

United States Public Health Resources

Innate CD8 + T cells express a memory-like phenotype and demonstrate a strong cytotoxic capacity that is critical during the early phase of the host response to certain bacterial and viral infections. These cells arise in the thymus and depend on IL-4 and IL-15 for their development. Even though innate CD8 + T cells exist in the thymus of WT mice in low numbers, they are highly enriched in KO mice that lack certain kinases, leading to an increase in IL-4 production by thymic NKT cells. Our work describes that in C57BL/6 WT mice undergoing a Th1 biased infectious disease, …

Comparative Characteristics Of Antibacterial Activity Of Plants Growing In The Central Part Of The Republic Of Tajikistan., Saidbeg Satorov, F. Mirzoeva, Sh. Satorov, M. Vakhidova, Vyacheslav Dushenkov

Publications and Research

Objective: To evaluate the spectrum of antibacterial activity of plants growing in the central part of the Republic of Tajikistan.
Methods: The antibacterial properties of 18 plant species from the 14 families were studied. The extract samples on dry filter discs were prepared according to the method developed at Rutgers University. Screens-to-Nature (STN) and disc diffusion (DD) methods were used to assess antimicrobial properties of the extracts. The antimicrobial activity of plant extracts was determined against four types of pathogenic standard museum strains of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, as well as …

Prevalence Of Enteric Helminths And Protozoa And Identification Of Hookworm, Threadworm And Giardia Spp. In Cats In Bangkok And Vicinity, Thailand, Wanarit Jitsamai

Chulalongkorn University Theses and Dissertations (Chula ETD)

A total of 835 fecal samples collected from client-owned and community cats between 2014 and 2016 were subjected to wet fecal smear and/or PBS-ethyl acetate and/or ZnSO4 centrifugal flotation. Ancylostoma spp. was the most common, 28.5%, followed by 6.7% Toxocara spp., 5.3% Cystoisospora spp., 4.4% Platynosomum fastosum, 2.5% Taenia taeniaeformis, 1.7% Strongyloides spp., 1.4% Spirometra spp., 1.3% Dipylidium caninum, 0.1% Eucoleus aerophilus and 0.1% Opisthorchis-like trematode egg. For retroviruses, FeLV and FIV were positive 7.1% (19/269) and 5.2% (14/269), respectively, without association with endoparasitic infection. Based on Giardia copro-antigen detection test, 3.9% (9/233) of tested cats were positive. From multivariable …

Predictive Relationship Between Socio-Demographics, Medication, And Treatment Completion Among Persons Experiencing Homelessness Treated For Tuberculosis, Sophia Ajoku

Walden Dissertations and Doctoral Studies

Approximately 80% of people who contract tuberculosis (TB) in the United States are first infected with untreated latent tuberculosis infection (LTBI). LTBI is an ongoing public health concern in people who experience homelessness. Because of the transient nature of this population, it is often difficult for them to adhere to and complete treatment for LTBI. In this quantitative, correlational of a cross-sectional study, secondary data was from a public health clinic in southern U.S. The theoretical framework used for the study was the social ecological framework. Multiple logistic regression was used to determine if a statistically significant predictive relationship existed …

Effects Of Commercial Feed Additives On The Gut Microbiota Of Food Animals, Prakash Poudel

Electronic Theses and Dissertations

Weaning is a stressful event of newborn animals which can lead to dysbiosis in the GIT causing invasion of pathogens, retarded growth, high incidence of diarrhea, and increased neonatal mortality. Since antibiotics use in livestock production have been regulated, various feed additives have been designed as antibiotic alternatives to use in newborn animal during weaning. This thesis investigated the dynamics of bacterial composition of GIT in weaned animals fed commercial feed additives by analysis of high throughput sequencing data generated from PCR-amplified DNA targeting V1-V3 region of 16S rRNA gene. Experiment 1 investigated the rumen environment of neonatal calves fed …

Increasing Accumulation Of Glyceollins In Soybeans Via Optimization Of The Fungal Incubation Process, Stephanie Wootton

Electronic Theses and Dissertations

Continual use of antibiotics in the feed of food animals was viewed a solution to the problem of disease outbreaks in livestock produced in confinement operations. This practice also improved animal performance, likely due to the reduction in sub-clinical infections. Unfortunately, this practice led to a new problem, the development of antibiotic resistant microbes. This increase in antibiotic resistance reduced the direct benefits of antibiotics in animal production. Moreover, as antibiotic resistance spread from animal to human pathogens, this practice created a major public health concern. This led the FDA to enact the Veterinary Feed Directive in 2017 that greatly …

Academic Preparation For Business, Industry, And Government Positions, Alejandra Alvarado, Candice R. Price

Mathematics Sciences: Faculty Publications

According to the 2015 Annual Survey of the Mathematical Sciences, 1901 PhDs were awarded in the USA. The report shows that 52% of those recipients are working in academia. This is a decrease from the 2014 survey which stated that 56% of new doctoral recipients went on to academia. Thus, what support do we, as academics, provide to this growing population of business/industry, or government job seekers? The goal of this paper is to provide insight into programs tackling this question along with relevant information and advice for new PhDs interested in jobs outside of academia as well as those …

Should Governments Tax The Rich And Subsidize The Poor? A Comparative Study Of Muslim And Christian Respondents, Robert W. Mcgee, Serkan Benk, Bahad?R Yüzba??

College of Business and Economics

This study used the most recent World Values Survey (WVS) dataset to determine whether Christian and Muslim views on the acceptability of taxing the rich and subsidizing the poor was an essential feature of democracy. The sample size included more than 23,000 individuals from more than 50 countries. More than a dozen socioeconomic and attitudinal variables were also examined to determine whether significant differences existed. The study found that differences in viewpoint were often significant.

Examining Factors Associated With Minority Turnover Intention In State And Local Public Health Organizations: The Relationship Among Diversity Climate, Career Growth Perception, Job & Organizational Satisfaction And Turnover Intention., Ashley Kennedy Mitchell

College of Graduate Studies: Theses & Dissertations

Research shows that a diverse workforce can increase workplace satisfaction, organizational performance, and retention (Konrad, 2006; Choi, 2013; McKay et al., 2007). There is a need to understand governmental public health workforce turnover to ensure the retention of public health minority workers, the capitalization on diversity benefits, and the services needed to provide for a more diverse population. This study aimed to assess the impact of the workforce environment, particularly employee perceptions of the diversity climate, individual career growth, and job and organizational satisfaction, on minority state and local health worker turnover intention. Data were analyzed from the 2017 The …

Characterization Of Ovine Monocytes In Response To Haemonchus Contortus Larvae In Vitro And A Novel Role Of Interleukin-13 Inducing Larval Paralysis, Elizabeth Shepherd

Graduate Theses, Dissertations, and Problem Reports (ETD)

Haemonchus contortus is a hematophagous, gastrointestinal parasite affecting small ruminants. Parasitism by H. contortus is the greatest concern of sheep producers in the United States and accounts for billions of dollars in economic loss worldwide. However, different breeds of sheep display differences n natural resistance to H. contortus. St. Croix hair sheep have a remarkable ability to clear H. contortus without the aid of anthelmintics and develop a robust T helper type 2 (Th2) immune response, preventing establishment of infective stage 3 larvae (L3), when compared to susceptible Suffolk sheep. However, the mechanism of development of immune response and …

Predictors Of Clostridioides Difficile Recurrence Across A National Cohort Of Veterans In Outpatient, Acute, And Long-Term Care Settings, Haley J. Appaneal, R. Caffrey, Maya Beganivic, Sanja Avramovic, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

Purpose: The greatest challenge in treating Clostridioides difficile infection (CDI) is disease recurrence, which occurs in about 20% of patients, usually within 30 days of treatment cessation. We sought to identify independent predictors of first recurrence among a national cohort of veterans with CDI.

Methods: We conducted a case-control study among acute and long-term care Veterans Affairs (VA) inpatients and outpatients with a first CDI episode (positive stool sample for C. difficile toxin[s] and receipt of at least 2 days of CDI treatment) between 2010 and 2014. Cases experienced first recurrence within 30 days from the end of …

Is There A Greater Statistically Significant Difference In The Clearance Or Partial Clearance Of Anogenital/Genital Warts When It Comes To Combination Therapies That Include Cryotherapy Versus Cryotherapy Alone?, Erika Burbano

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine if there is a statistically significant difference in using combination therapies that include cryotherapy vs. cryotherapy alone in the clearance of genital/anogenital warts.

STUDY DESIGN: Systematic review of three peer reviewed primary studies that were published between 2009-2014.

DATA SOURCES: Review of a double-blind placebo-controlled study, a single-blinded randomized controlled study, and a randomized clinical comparative study from 2011. All sources were selected from PubMed based on the applicability to the clinical question and how accurately they answered the question regarding the patient population

OUTCOMES: The outcomes of investigation …

Examining The Relationship Between Medical Student Satisfaction And Academic Performance In A Pre-Clinical, Flipped-Classroom Curriculum, Matthew J. Mackey

Scholarship in Medicine - All Papers

Medical schools are tasked with the responsibility of facilitating the acquisition of the specific vernacular, skill set, and reasoning capabilities of a physician for a group of individuals with a mélange of diverse experiences. Determining the best methods to train physicians is thus a challenge for those in medical education. Starting with the class of 2021, flipped classroom teaching and learning activities dominate Wright State University Boonshoft School of Medicine’s (WSU-BSOM) curriculum for MS1s and MS2s. This new curriculum is under constant evaluation to make sure it is best serving Boonshoft students. However, evaluating student evaluations on course satisfaction is …

New Host Records And Range Extensions For Helminth Parasites From Wading Birds In Southeastern Florida, Sarah E. Gumbleton, David W. Kerstetter, Amy C. Hirons, Christopher A. Blanar

Florida Field Naturalist

No abstract provided.

Public Health And Personal Choice: The Ethics Of Vaccine Mandates And Parental Refusal In The United States, Rebecca Horan

Undergraduate Honors Theses

No abstract provided.

Factors Affecting Health Care Access And Utilization Among U.S. Migrant Farmworkers, Melinda R. Kelly

Walden Dissertations and Doctoral Studies

There are over 3 million seasonal and migrant farmworkers in the U.S. agricultural industry with a significant percentage of farmworkers documented or native to the United States. Migrant farmworkers live below the federal poverty levels at high rates and experience low health care access and utilization. Guided by the fundamental cause theory, the purpose of this phenomenological study was to examine the lived experiences of migrant farmworkers and identify the factors impacting their health care access and utilization. Face-to-face interviews were conducted with 12 migrant farmworkers who had worked in Southwest Texas agricultural stream. Data were analyzed and coded to …

Family Predictive Factors Of Rural Malaria Prevalence In Nsukka, Eastern Nigeria, Gabriel Ugwuja Ugwu

Walden Dissertations and Doctoral Studies

Children in early childhood are still suffering from burdens of malaria-related morbidity and mortality. There have been insufficient studies on how family-level factors may predict the prevalence of malaria (PoM), and negatively impact the control of malaria in rural areas, especially among children. In this study, potential family factors were explored to address the challenges associated with the increase in PoM among the children in rural areas of Nsukka. Socioecological framework guided this study at the interpersonal level. The quantitative cross-sectional study used secondary data from Demographic and Health Surveys (DHS) of 2015 in Nsukka rural communities. Data were analyzed …

Connecticut Primary Care Physicians And Chronic Lyme Disease, Yvette P. Ghannam

Walden Dissertations and Doctoral Studies

The prevalence of chronic Lyme disease (CLD) remains relatively unknown in Connecticut because there is not an agreement on what CLD is and how it should be diagnosed in addition to which pathological agent causes CLD. The aim of this quantitative study was to assess whether there were significant differences between two groups of primary care physicians (PCP) working in Connecticut from two different points in time regarding their knowledge in the diagnosis, treatment, and management of CLD. A knowledge, attitude, and practice model was used as the underlying theoretical framework for this study. A random cross-sectional survey was mailed …

The Religious Exemption Loophole: A Building Public Health Crisis In North Carolina, Brian Champion

North Carolina Law Review

No abstract provided.

Developing Product Label Information To Support Evidence-Informed Use Of Vaccines In Pregnancy, Terra A. Manca, Janice E. Graham, Ève Dubé, Melissa Kervin, Eliana Castillo, Natasha S. Crowcroft, Deshayne B. Fell, Michael Hadskis, Jaelene M. Mannerfeldt, Devon Greyson, Noni E. Macdonald, Karina A. Top, On Behalf Of The Canadian Vaccine Product Monograph Working Group

Articles, Book Chapters, & Popular Press

Background: Product labelling information describing the use of vaccines in pregnancy continues to contain cautionary language even after clinical and epidemiological evidence of safety becomes available. This language raises safety concerns among healthcare providers who may hesitate to recommend vaccines during pregnancy.

Purpose: To develop clear evidence-based language about vaccine safety and effectiveness in pregnancy for inclusion in vaccine product labels.

Methods: We conducted a three-stage consensus-methods project with stakeholders, including: healthcare providers, vaccine regulators, industry representatives, and experts in public health, communication, law, ethics, and social sciences. Using qualitative and quantitative methods, we held a nominal group technique (NGT) …

Catching Congress Up: Restoring The Office Of Technology Assessment, Bruno Youn

CMC Senior Theses

Congress has become infamous for its lack of understanding of technology, particularly with the Facebook and Google hearings in 2018. To improve this understanding, this thesis argues for the return of the Office of Technology Assessment (OTA), a congressional support agency created in 1972 that provided science and technology expertise to Congress until its termination in 1995. It also considers potential changes that might be made to the old OTA model and the political environment in which a new OTA would need to survive.

The War On Drugs In Contrast To The War On Big Pharma: Contextualizing Shifts In Drug Policy During The Opioid Crisis, Alexandra Carter

CMC Senior Theses

New drug epidemics often unleash punitive campaigns to end them- highlighted by the 1980’s drug wars. However, the opioid crisis has been met with public-health driven policies, like clean needle programs and community-based substance abuse therapy. This thesis asks why policy responses to the opioid crisis are so different than those of the War on Drugs.

First, as the cost of the drug war became clearer, policy makers across the political spectrum became less inclined to wage a new punitive war against opioids, especially as public-health responses proved to be more effective while also less costly.

Second, the demographics of …

The Intersection Of Indigenous Public Health With Law And Policy In Canada, Constance Macintosh

Articles, Book Chapters, & Popular Press

This chapter presents an overview of the law, policy and governance practices that are most directly implicated in the population health of Indigenous people who reside in Canada. The first section provides a general description of the socio-legal categories that are drawn upon in health policy, programming and legislation regarding Indigenous peoples. It briefly describes roles in funding and delivering community health services and programming, as well as disputes about responsibilities and some shortcomings.

The second section provides an overview of the population health status of Indigenous peoples. Epidemiological data is presented, and select social determinants of health are also …

Reputation And Accountability: Another Look At The United Nations’ Response To The Cholera Epidemic In Haiti, Kristina Daugirdas

Articles

The cholera outbreak in Haiti offers a useful case study of reputation as a disciplinarian of international organizations. On the one hand, UN officials and member states alike have emphasized the need to repair the organization’s damaged reputation. On the other hand, the UN secretariat declined to take certain steps that might have averted—or at least mitigated—that reputational damage in the first place. This contribution argues that the United Nations’ response to cholera in Haiti showcases some important limitations and complications of reputation as a disciplinarian. Reputation will function as a less effective disciplinarian of organizations in the context of …

Pulmonary Vein Thrombosis Secondary To Tuberculosis In A Non-Hiv Infected Patient, Yonas Raru, Jason Ballengee, Mahmoud Abouzid, Samson Teka

Pulmonology

Tuberculosis has been suggested as an independent risk factor for thromboembolism due to a hypercoagulable state induced by changes in clotting factors, protein C and vascular endothelium. Pulmonary vein thrombosis (PVT) is a rare, potentially serious and life-threatening condition that can be caused by tuberculosis. Its rare occurrence is due to a rich network of venous collateral vessels that drain the lung. PVT can also occur following lobectomy for malignancy, lung transplantation, radiofrequency catheter ablation for atrial fibrillation, sclerosing mediastinitis and following metastatic cancer, such as liposarcoma. Pulmonary vein thrombosis is difficult to diagnose clinically and requires a combination of …

Regulatory Gaps In Drug Compounding: Implications For Patient Safety, Innovation, And Fraud, Joanna Shepherd

Faculty Articles

Drug compounding is the practice of mixing, combining, or altering drug ingredients to create a product that meets the medical needs of a patient whose needs cannot otherwise be met with commercially-available products. Compounding is essential for patients that are allergic to certain ingredients or cannot tolerate the route of administration or dosage form of a commercially-available drug. Compounding may also enable pharmacists to supply medications when there is a shortage of commercially-available drugs. For example, amid the nationwide shortage of generic liquid Tamiflu and growing flu deaths in early 2018, pharmacists around the country used Tamiflu capsules to compound …

Environmental Health Needs Assessment Base On Priority Need Index Corresponding With Health Effects From Flood For Improving Local Government Action Plans: A Case Study Of Nakhon Si Thammarat Province, Thailand, Jariya Matrongduang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Flooding is considered as one of disaster that affect more people than any other natural disaster. The effects of flooding are extremely dangerous in developing countries due to low level flood protection. Initiatives in the development of response to floods need to create responses and support from stakeholders to identify causes, decision makers and local solutions. However, there’s limited studies on environmental health needs assessment for local government flood response. The purposes of this study are access environmental health needs of flooding action plan among affected people and compare environmental health needs between people who have and non-have health related …