Digital Commons Network^™

Timely Linkage Of Individuals To Substance Use Disorder Treatment: Development, Implementation, And Evaluation Of Findhelpnowky.Org, Terry Lee Bunn, Dana Quesinberry, Tyler Jennings, Amber Kizewski, Heather Jackson, Sarah Mckee, Sarah Eustice

Kentucky Injury Prevention and Research Center Faculty Publications

Background: Substance use disorders (SUD) have steadily increased over the last two decades. Seeking SUD treatment involves searching SUD treatment facility types (inpatient, outpatient and intensive outpatient, residential and family residential, and detoxification facilities) that offer specialized SUD treatment depending on individual needs and preferences. Referrals to SUD treatment require innovative strategies that rapidly link individuals to SUD treatment when they are at the critical stage of readiness. The aim of this study was to develop, implement, and evaluate a user-friendly SUD treatment facility opening availability website called FindHelpNowKY.org. The objectives of the study were to 1) recruit SUD treatment …

Seasonal Variation Of Contaminant Concentrations In Wastewater Treatment Works Effluents And River Waters., S. D.W. Comber, M. J. Gardner, B. Ellor

School of Geography, Earth and Environmental Sciences

Results are presented for 170 wastewater treatment works sites (20 per substance in influent, effluent and 36 per substance in river water upstream and downstream of the WwTW discharge) over a period of two years between 2015 and 2017; this comprises data for approximately 3000 samples for effluent and 6000 for river samples taken downstream of effluent discharges. Seasonal trends in contaminant concentrations for several substances are reported. Two clear patterns of seasonal variation are proposed over and above all of the variables associated with environmental data including process technology, dilution and geography. Firstly, variation of riverine concentrations caused by …

Differential Diagnosis Between The Varieties Of Vasculitis Forms, Joana Hankollari, Marsida Duli, Qamil Dika, Xhenila Duli, Indrit Bimi, Daniela Dervishi

International Journal of Business and Technology

Vasculitis is an inflammation of the blood vessels. It can affect any blood vessel in the body by manifesting a variety of systemic, non-specific symptoms that make difficult the diagnosis of this pathology and especially its specific form. In front of any patient suspected of being affected by vasculitis, some questions are asked: Is the vasculitis or other pathology that camouflages, whether it is primary or secondary vasculitis, in which vessels this pathology extends, how can the diagnosis be confirmed and how can it be determined the type of vasculitis?The purpose of this study is to inform about the protocols …

Spatio-Temporal Patterns And Characteristics Of Swine Shipments In The U.S. Based On Interstate Certificates Of Veterinary Inspection, Erin E. Gorsich, Ryan S. Miller, Holly M. Mask, Clayton Hallman, Katie Portacci, Colleen T. Webb

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Domestic swine production in the United States is a critical economic and food security industry, yet there is currently no large-scale quantitative assessment of swine shipments available to support risk assessments. In this study, we provide a national-level characterization of the swine industry by quantifying the demographic (i.e. age, sex) patterns, spatio-temporal patterns, and the production diversity within swine shipments. We characterize annual networks of swine shipments using a 30% stratified sample of Interstate Certificates of Veterinary Inspection (ICVI), which are required for the interstate movement of agricultural animals. We used ICVIs in 2010 and 2011 from eight states that …

Utility Of Combination Antimicrobial Therapy In Adults With Bloodstream Infections Due To Enterobacteriaceae And Non-Fermenting Gram-Negative Bacilli Based On In Vitro Analysis At Two Community Hospitals, Rachel Foster, Casey Troficanto, P. Brandon Bookstaver, Joseph Kohn, Julie Ann Justo, Majdi Al-Hasan

Faculty Publications

This study examined the utility of combination therapy for bloodstream isolates of Enterobacteriaceae and non-fermenting Gram-negative bacilli (NFGN) from adults at two community hospitals from January 2010 through to June 2015. Changes to in vitro antimicrobial susceptibilities by adding ciprofloxacin or gentamicin to third-generation cephalosporins (3GC) were examined overall and in patients with risk factors for 3GC resistance. Overall ceftriaxone susceptibility among Enterobacteriaceae was 996/1063 (94%) and 247/295 (84%) in patients with 3GC resistance risk factors. Susceptibilities increased marginally by adding ciprofloxacin or gentamicin (mean difference 2.4% (95% CI 1.5, 3.4) and 3.0% (95% CI 2.0, 4.0), respectively, overall and …

Strengthened Scientific Support For The Endangerment Finding For Atmospheric Greenhouse Gases, Pb Duffy, Cb Field, Ns Diffenbaugh, Sc Doney, Et Al

School of Biological and Marine Sciences

We assess scientific evidence that has emerged since the U.S. Environmental Protection Agency’s 2009 Endangerment Finding for six well-mixed greenhouse gases and find that this new evidence lends increased support to the conclusion that these gases pose a danger to public health and welfare. Newly available evidence about a wide range of observed and projected impacts strengthens the association between the risk of some of these impacts and anthropogenic climate change, indicates that some impacts or combinations of impacts have the potential to be more severe than previously understood, and identifies substantial risk of additional impacts through processes and pathways …

Event Program, Emory Law Journal

Randolph W. Thrower Symposium

No abstract provided.

A Pilot Study Of The Effects Of Mycoplasma Ovipneumoniae Exposure On Domestic Lamb Growth And Performance, Thomas E. Besser, Jessica Levy, Melissa Ackerman, Danielle Nelson, Kezia R. Manlove, Kathleen A. Potter, Jan Busboom, Margaret Benson

Wildland Resources Faculty Publications

Mycoplasma ovipneumoniae is a globally distributed pathogen that has been associated with pneumonia in both domestic and wild Caprinae. It is closely related to M. hyopneumoniae, a respiratory pathogen of swine that is associated with decreased growth rates of pigs as well as clinical respiratory disease. In order to assess the effects of M. ovipneumoniae on lamb performance, we generated a cohort of lambs free of M. ovipneumoniae by segregation of test negative ewes after lambing, then compared the growth and carcass quality traits of M. ovipneumoniae-free and -colonized lambs from weaning to harvest. Some signs of respiratory disease …

Early Dexamethasone Administration In Adults With Suspected Meningitis Lowers Morbidity And Mortality, Dana Siegel

Clinical Research in Practice: The Journal of Team Hippocrates

A critical appraisal and clinical application of de Gans J, van de Beek D, Investigators EDiABMS. Dexamethasone in adults with bacterial meningitis. New Eng J Med. 2002;347(20):1549-1556. doi: 10.1056/NEJMoa021334.

Volume 56, Number 25: February 06, 2019, University Of North Dakota

University Letter Archive

No abstract provided.

Ic 042 Gude To Texas Children's Hospital Historical Archives, 1953-2003, Texas Children's Hospital

Institutional Finding Aids

Texas Children's Hospital Historical Archives contains 10 cubic feet of processed material and 79 boxes of unprocessed material. The later is labeled as the TCH Historical Archives and arrived in the HRC in 2008. See more at IC 042.

Betting On Climate Policy: Using Prediction Markets To Address Global Warming, Gary M. Lucas Jr, Felix Mormann

Faculty Scholarship

Global warming, sea level rise, and extreme weather events have made climate change a top priority for policymakers across the globe. But which policies are best suited to tackle the enormous challenges presented by our changing climate? This Article proposes that policymakers turn to prediction markets to answer that crucial question. Prediction markets have a strong track record of outperforming other forecasting mechanisms across a wide range of contexts — from predicting election outcomes and economic trends to guessing Oscar winners. In the context of climate change, market participants could, for example, bet on important climate outcomes conditioned on the …

Blood Parasites Infecting The Hoatzin (Opisthocomus Hoazin), A Unique Neotropical Folivorous Bird, M. Andreína Pacheco, M. Alexandra García-Amado, Jaime Manzano, Nubia E. Matta, Ananias A. Escalante

Harold W. Manter Laboratory of Parasitology: Library Materials

The Hoatzin (Opisthocomus hoazin) is the only extant member of the order Opisthocomiformes. This unique South American bird lives in the riparian lowland vegetation characteristic of the Amazon and Orinoco basins. Hoatzins nest in communal social units close to water bodies; they are strictly folivores being the only bird with pregastric fermentation in the crop. Because of the complex logistics involved in capturing this bird, there is a knowledge gap on its parasites. This study documents two distant lineages of haemosporidian parasites (Plasmodium spp.) in a juvenile and two adults sampled in the Cojedes state, Venezuela. Although …

Correction To: Nasopharyngeal Carriage Of Streptococcus Pneumoniae In Children Under 5 Years Of Age Before Introduction Of Pneumococcal Vaccine (Pcv10) In Urban And Rural Districts In Pakistan, Muhammad Imran Nisar, Kanwal Nayani, Tauseef Akhund, Atif Riaz, Omar Irfan, Sadia Shakoor, Sehrish Muneer, Sana Muslim, Aneeta Hotwani, Furqan Kabir, Cynthia Whitney, Lindsay Kim, Velusamy Srinivasan, Syed Asad Ali, Anita K. M. Zaidi, Fyezah Jehan

Department of Paediatrics and Child Health

No abstract provided.

Finding The 'Qr' To Patient Safety: Applying Gamification To Incorporate Patient Safety Priorities Through A Simulated 'Escape Room' Experience., Xiao Chi Zhang, Gretchen Diemer, Hyunjoo Lee, Rebecca Jaffe, Dimitrios Papanagnou

Department of Emergency Medicine Faculty Papers

Medical errors are the eighth leading cause of mortality in the United States and contribute to over one million preventable injuries. In an effort to prevent medical errors, reporting systems serve as invaluable tools to detect patient safety events and quality problems longitudinally. Historically, trainees (i.e., students and residents) rarely submit incident reports for encountered patient safety threats. The authors propose an immersive learning experience utilizing gamification theory and leveraging the increasingly popular ‘escape room’ to help resident trainees identify reportable patient safety priorities. All 130 incoming intern physicians at the Thomas Jefferson University (Jefferson) were enrolled in the Patient …

A Variant In The Mica Gene Is Associated With Liver Fibrosis Progression In Chronic Hepatitis C Through Tgf-Β1 Dependent Mechanisms., Rasha El Sharkawy, Ali Bayoumi, Mayada Metwally, Alessandra Mangia, Thomas Berg, Manuel Romero-Gomez, Maria Lorena Abate, William L. Irving, David Sheridan, Gregory J. Dore, Ulrich Spengler, Pietro Lampertico, Elisabetta Bugianesi, Martin Weltman, Lindsay Mollison, Wendy Cheng, Stephen Riordan, Rosanna Santoro, Rocío Gallego-Durán, Janett Fischer, Jacob Nattermann, R D'Ambrosio, Duncan Mcleod, Elizabeth Powell, Olivier Latchoumanin, Khaled Thabet, Mustafa A.M. Najim, Mark W. Douglas, Christopher Liddle, Christopher Liddle, Jacob George, Mohammed Eslam, Liver Disease Genetics Consortium (Ildgc) International

Peninsula Medical School

Hepatocarcinogenesis is tightly linked to liver fibrosis. Recently, two GWAS variants, MICA rs2596542 and DEPDC5 rs1012068 were identified as being associated with the development of HCV-induced hepatocellular carcinoma (HCC) in Japanese patients. The role of these variants on hepatic inflammation and fibrosis that are closely associated with HCC development is not known, nor are the biological mechanisms underlying their impact on the liver. Here, we demonstrate in 1689 patients with chronic hepatitis C (CHC) (1,501 with CHC and 188 with HCV-related HCC), that the MICA (T) allele, despite not being associated with HCC susceptibility, is associated with increased fibrosis stage …

Development Of A Novel Loop-Mediated Isothermal Amplification Method To Detect Guiana Extended-Spectrum (Ges) Β-Lactamase Genes In Pseudomonas Aeruginosa, Chika Takano, Mitsuko Seki, Dong Wook Kim, Humphrey Gardner, Robert E. Mclaughlin, Paul E. Kilgore, Kazunari Kumasaka, Satoshi Hayakawa

Department of Pharmacy Practice

Infections caused by multidrug-resistant Pseudomonas aeruginosa in hospitalized patients are often fatal, and nosocomial infections caused by Guiana extended-spectrum (GES) β-lactamase-producing strains are of growing concern. Several genotypes of the GES β-lactamase gene (bla_GES) include a single missense mutation, a change from G to A at nucleotide position 493 (G_493A) that changes glycine to serine; the mutant enzyme exhibits carbapenemase activity. Rapid and reliable identification of drug-resistance is important in clinical settings; however, culture methods remain the gold standard. Conventional and real-time PCR cannot identify carbapenemase-producing genotypes, and direct DNA sequencing is essential. We established …

Ada News - 02/04/2019, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Faculty Senate Agenda, February 4, 2019, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• EPC Monthly Report – January 10, 2019
• Academic Freedom and Tenure Annual Report
• Council on Teacher Education Annual Report
• 405.7.2 – External Reviewers
• Greenhouse Gas Resolution
• 403.3.1 – Standards of Conduct – Faculty Responsibilities to Students
• 403.3.2 – Standards of Conduct – Professional Obligations
• 405.2.1 – 405.3.2 – 405.5.1 – 405.10.1 Community Engagement Inclusion
• 407.1.1 – Non Punitive Measure
• 407.8.5(3) – Sexual Harassment
• 407.11.2(2) - Notification of Faculty Member
• 407.11.3(2) – Protection of Complainant and Others

Faculty Senate Minutes, February 4, 2019, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• Academic Freedom and Tenure
• Council on Teacher Education
• Greenhouse Gas Resolution

Identification And Treatment Of Sepsis In The Field, Jamie Roney

Books, Presentations, Posters, Etc.

No abstract provided.

Would “Hamsterdam” Work? Drug Depenalization In The Wire And In Real Life, John Bronsteen

University of Chicago Legal Forum

The television show The Wire depicts a plan called “Hamsterdam” in which police let people sell drugs in isolated places, and only those places, without fear of arrest. Based on limited but decent empirical evidence, we can make educated guesses about what would happen if that were tried in real life. Indeed, Swiss police tried something remarkably similar in the 1980s. More generally, the results of various forms of drug legalization, depenalization, and decriminalization in Europe—such as in Portugal, which has transferred the state’s method of dealing with drug use (including heroin and cocaine) from the criminal justice system to …

Determining Best Practices For Management Of Bacteriuria In Spinal Cord Injury: Protocol For A Mixed-Methods Study, Felicia Skelton, Lindsey Ann Martin, Charlesnika T. Evans, Jennifer Kramer, Larissa Grigoryan, Peter Richardson, Mark E. Kunik, Ivy Oiyee Poon, S. Ann Holmes, Barbara W. Trautner

Faculty Publications

Background: Bacteriuria, either asymptomatic (ASB) or symptomatic, urinary tract infection (UTI), is common in persons with spinal cord injury (SCI). Current Veterans Health Administration (VHA) guidelines recommend a screening urinalysis and urine culture for every veteran with SCI during annual evaluation, even when asymptomatic, which is contrary to other national guidelines. Our preliminary data suggest that a positive urine culture (even without signs or symptoms of infection) drives antibiotic use. Objective: Through a series of innovative studies utilizing mixed methods, administrative databases, and focus groups, we will gain further knowledge about the attitudes driving current urine testing practices during the …

Enhanced Il-1Β Production Is Mediated By A Tlr2-Myd88-Nlrp3 Signaling Axis During Coinfection With Influenza A Virus And Streptococcus Pneumoniae, Angeline E. Rodriguez, Christopher Bogart, Christopher M. Gilbert, Jonathan A. Mccullers, Amber M. Smith, Thirumala Devi Kanneganti, Christopher Lupfer

College of Natural and Applied Sciences

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Viral-bacterial coinfections, such as with influenza A virus and Streptococcus pneumoniae (S.p.), are known to cause severe pneumonia. It is well known that the host response has an important role in disease. Interleukin-1β (IL-1β) is an important immune signaling cytokine responsible for inflammation and has been previously shown to contribute to disease severity in numerous infections. Other studies in mice indicate that IL-1β levels are dramatically …

3d-Printed Isoniazid Tablets For The Treatment And Prevention Of Tuberculosis—Personalized Dosing And Drug Release, Heidi Öblom, Jiaxiang Zhang, Manjeet Pimparade, Isabell Speer, Maren Preis, Michael Repka, Niklas Sandler

Faculty and Student Publications

© 2019 by the authors. Although 4-O-Methylhonokiol (MH) effects on neuronal and immune cells have been established, it is still unclear whether MH can cause a change in the structure and function of the cardiovascular system. The overarching goal of this study was to evaluate the effects of MH, isolated from Magnolia grandiflora, on the development of the heart and vasculature in a Japanese medaka model in vivo to predict human health risks. We analyzed the toxicity of MH in different life-stages of medaka embryos. MH uptake into medaka embryos was quantified. The LC50 of two different exposure windows (stages …

Shifts In Leukocyte Counts Drive The Differential Expression Of Transcriptional Stroke Biomarkers In Whole Blood, Grant C. O'Connell, Madison B. Treadway, Connie S. Tennant, Noelle Lucke-Wold, Paul D. Chantler, Taura L. Barr

Clinical and Translational Science Institute

Our group recently identified a panel of ten genes whose RNA expression levels in whole blood have utility for detection of stroke. The purpose of this study was to determine the mechanisms by which these genes become differentially expressed during stroke pathology. First, we assessed the transcriptional distribution of the ten genes across the peripheral immune system by measuring their expression levels on isolated neutrophils, monocytes, B-lymphocytes, CD-4+ T-lymphocytes, CD-8+ T-lymphocytes, and NK-cells generated from the blood of healthy donors (n = 3). Then, we examined the relationship between the whole-blood expression levels of the ten genes and white blood …

Decrease In Population And Increase In Welfare Of Community Cats In A Twenty-Three Year Trap-Neuter-Return Program In Key Largo, Fl: The Orcat Program, Rachael Kreisler, Heather Cornell, Julie Levy

Management - TNR

The objective of this study was to evaluate the effect of a long-term (23-year) trap-neuter-return program on the population size of community cats in the Ocean Reef Community and to describe the demographic composition and outcome of enrolled cats. A retrospective study was performed using both cat census data collected between 1999 and 2013 as well as individual medical records for cats whose first visit occurred between 3/31/1995 and 12/31/2017. Medical record entries were reviewed to determine program inputs, cat outcomes, retroviral disease prevalence, and average age of first visit, sterilization, and death through 6/11/2018. Change over time was analyzed …

Biom 227.01: Vectors And Parasites, James D. Driver

University of Montana Course Syllabi

No abstract provided.

Supportive Hand-Holding Attenuates Pupillary Responses To Stress In Adult Couples, Wendy C. Birmingham, Tyler C. Graff, Steven G. Luke

Faculty Publications

Background

Social relationships, particularly marriage, have been shown to ameliorate the potentially pathogenic impact of stressful events but prior research has been mostly aimed at downstream effects, with less research on real-time reactivity. Pupillometry is an innovative procedure that allows us to see the effects of acute stress in real time. The muscles that control pupil size are linked to the autonomic nervous system, so that when stressed, the pupils dilate; this occurs within 200ms. This quick response allows us to see the immediate effects of acute stress on the autonomic nervous system (ANS), and the real-time effects of social …

Towards Multi-Lingual Pneumonia Research Data Collection Using The Community-Acquired Pneumonia International Cohort Study Database, William A. Mattingly, Kimberley A. Buckner, Senen Pena

The University of Louisville Journal of Respiratory Infections

Background: Although multilingual interfaces are preferred by most users when they have a choice, organizations are often unable to support and troubleshoot problems involving multiple user languages. Software that has been structured with multiple languages and data interlinking considerations early in its development is more likely to be easily maintained. We describe the process of adding multilingual support to the CAPO international Cohort study database using REDCap.

Methods: Using Google Translate API we extend the supported Spanish language version of REDCap to the most recent version used by CAPO, 8.1.4. We then translate the English data dictionary for CAPO to …