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Dean's Research Newsletter, Summer 2019, Jerry L. Nadler

SOM Dean's Research Newsletter

No abstract provided.

Summer 2019 Gsbms Alumni Connections, New York Medical College

Graduate School of Biomedical Sciences

• New York Medical College Celebrates 160th Commencement
• Inaugural Clinical Laboratory Sciences Class Arrives at NYMC
• NYMC Researchers Aim to Transform Treatment of Babesiosis
• Department of Cell Biology and Anatomy Hosts Annual Research Forum
• NYMC Observes Yom Hashoah, Holocaust Remembrance Day
• Lectureship Honors the Late Gabor Kaley, Ph.D.
• Center for Disaster Medicine Receives Funding and Expands Training Programs
• Graduate Student Research Forum Displays a Broad Field of Research

Biology, Saint Mary's College Of California

Academic Catalog

No abstract provided.

The Concentration Of Total Nucleated Cells In Harvested Bone Marrow For Transplantation Has Decreased Over Time., Nicole L. Prokopishyn, Brent R. Logan, Deidre M. Kiefer, Jennifer A. Sees, Pintip Chitphakdithai, Ibrahim A. Ahmed, Paolo N. Anderlini, Amer M. Beitinjaneh, Christopher Bredeson, Jan Cerny, Saurabh Chhabra, Andrew Daly, Miguel Angel Diaz, Nosha Farhadfar, Haydar A. Frangoul, Siddhartha Ganguly, Dennis A. Gastineau, Usama Gergis, Gregory A. Hale, Peiman Hematti, Rammurti T. Kamble, Kimberly A. Kasow, Hillard M. Lazarus, Jane L. Liesveld, Hemant S. Murthy, Maxim Norkin, Richard F. Olsson, Mona Papari, Bipin N. Savani, Jeffrey Szer, Edmund K. Waller, Baldeep Wirk, Jean A. Yared, Michael A. Pulsipher, Nirali N. Shah, Galen E. Switzer, Paul V. O'Donnell, Dennis L. Confer, Bronwen E. Shaw

Manuscripts, Articles, Book Chapters and Other Papers

Bone marrow (BM) is an essential source of hematopoietic stem cell grafts for many allogeneic hematopoietic cell transplant (HCT) recipients, including adult patients (for specific diseases and transplantation strategies) and the majority of pediatric recipient. However, since the advent of granulocyte colony-stimulating factor-mobilized peripheral blood stem cell (PBSC) grafts, there has been a significant decrease in the use of BM in HCT, thought to be due mainly to the increased logistical challenges in harvesting BM compared with PBSCs, as well as generally no significant survival advantage of BM over PBSCs. The decreased frequency of collection has the potential to impact …

Variability In Catheter-Associated Asymptomatic Bacteriuria Rates Among Individual Nurses In Intensive Care Units: An Observational Cross-Sectional Study, Olga Yakusheva, Deena K. Costa, Kathleen L. Bobay, Jorge P. Parada, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Catheter-associated asymptomatic bacteriuria (CAABU) is frequent in intensive care units (ICUs) and contributes to the routine use of antibiotics and to antibiotic-resistant infections. While nurses are responsible for the implementation of CAABU-prevention guidelines, variability in how individual nurses contribute to CAABU-free rates in ICUs has not been previously explored. This study’s objective was to examine the variability in CAABU-free outcomes of individual ICU nurses. This observational cross-sectional study used shift-level nurse-patient data from the electronic health records from two ICUs in a tertiary medical center in the US between July 2015 and June 2016. We included all adult (18+) catheterized …

Use Of The Who Access, Watch, And Reserve Classification To Define Patterns Of Hospital Antibiotic Use (Aware): An Analysis Of Paediatric Survey Data From 56 Countries., Yingfen Hsia, Brian R. Lee, Ann Versporten, Yonghong Yang, Julia Bielicki, Charlotte Jackson, Jason Newland, Herman Goossens, Nicola Magrini, Mike Sharland, Garpec And Global-Pps Networks

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Improving the quality of hospital antibiotic use is a major goal of WHO's global action plan to combat antimicrobial resistance. The WHO Essential Medicines List Access, Watch, and Reserve (AWaRe) classification could facilitate simple stewardship interventions that are widely applicable globally. We aimed to present data on patterns of paediatric AWaRe antibiotic use that could be used for local and national stewardship interventions.

METHODS: 1-day point prevalence survey antibiotic prescription data were combined from two independent global networks: the Global Antimicrobial Resistance, Prescribing, and Efficacy in Neonates and Children and the Global Point Prevalence Survey on Antimicrobial Consumption and …

Mapping Life Sciences & Biomedicine Research, Shah Salma, B. Mini Devi

Library Philosophy and Practice (e-journal)

Purpose: This study analyzes and highlights the research productivity and the trend in the top fields of “Life sciences and Biomedicine”.

Methods: The data were collected from Clarivate Analytic’s “Web of Science” for a period of 10 years (2006-2016). The search was further refined to the top 10 fields in the field of “Life Sciences and Biomedicine”. The data were downloaded on the following parameters: “author productivity”, “country contribution”, “organisational involvement”, “funding agencies”, “publication year”, “most preferred document type” and “language”.

Findings: No consistent growth is observed in the research activities pertinent to the fields of “Life …

Costas T. Lambrew Research Retreat At Maine Medical Center - Abstracts From 2019

Journal of Maine Medical Center

No abstract provided.

Increasing Actual And Perceived Burden Of Tick-Borne Disease In Maine, Robert P. Smith Md Mph, Carol A. Mccarthy Md, Susan P. Elias Phd

Journal of Maine Medical Center

Introduction: The burden of tick-borne disease (TBD) in Maine has steadily increased since the first case of Lyme disease was reported in the late 1980s. The emergence of five different agents of TBD in Maine has been challenging and confusing for clinicians and the public.

Methods: We reviewed the ecology of emerging of tick -borne disease, then reviewed risk factors for tick bites and tick-borne disease in Maine. We then compared the burden of TBD versus community-acquired comparison infections in terms of hospitalizations, deaths, and media attention.

Results and Discussion: In Maine, risk of exposure to bites from the vector …

Signs Of Psychosis Leading To A Diagnosis Of Progressive Multifocal Leukoencephalopathy: A Case Report, Bryan L. Walker, Christina Holt Md, Msc

Journal of Maine Medical Center

Introduction: Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating process of the central nervous system that occurs in in the setting of severe immunocompromise. Patients with PML develop varying focal neurological deficits and mental status changes that have not been well-described previously.

Clinical findings: We present a patient who was found by security wandering the lobby of this hospital. He was oriented only to self and unable to state a reason for presentation. Medical records were limited and included a visit to an outside hospital that documented a past medical history of HIV infection. He exhibited multiple signs of psychosis …

2018-2019 Department Of Surgery Scholarly Activity Report, Quillen College Of Medicine, East Tennessee State University

Quillen College of Medicine Scholarly Activity Reports

No abstract provided.

2018-2019 Department Of Biomedical Sciences Scholarly Activity Report, Quillen College Of Medicine, East Tennessee State University

Quillen College of Medicine Scholarly Activity Reports

No abstract provided.

Association Between Silica Dust Exposure And Serum Transforming Growth Factor-Β1 In Stone Quarry Workers, I Putu Eka Krisnha Wijaya, Ida Bagus Ngurah Rai, I Putu Andrika

Jurnal Penyakit Dalam Indonesia

Introduction. Silicosis is a disease that most often occurred as a result of silica dust exposure. Silica dust particles will stimulate alveolar macrophages to secrete proinflammatory mediators for fibroblast proliferation and collagen deposition. TGF-ß1 is one of the most extensively involved mediators in the development of fibrosis. To date, several studies have not shown consistent results regarding the association between silica dust exposure and TGF-β1. This study examined silica dust exposure and serum TGF-β1, which aims to determine the risk of silicosis in stone quarry workers. Methods. An analytic cross-sectional study was conducted at Company X, Karangasem in March 2016. …

Correlation Between Proper Antibiotics Administration To Community Acquired Pneumonia Patients Based On Alur Gyssens With Clinical Response, Cleopas Martin Rumende, Lie Khie Chen, Anis Karuniawati, Joyce Bratanata, Rezyta Falasiva, Truly Panca Sitorus, Erwin Christian Susanto

Jurnal Penyakit Dalam Indonesia

Introduction. The proper of antibiotics treatment will increase the improvement of the patient with community-acquired pneumonia (CAP) and also counteract antimicrobial resistance. Community-Acquired Pneumonia is commonly found in Indonesia with an incidence of 2.4%. This study aimed to determine the proper of antibiotic selection for CAP based on IDSA-ATS 2007 guidelines with Gyssens method and evaluate the relationship between the proper of antibiotic treatment with the clinical response of patients. Methods. A retrospective cohort study was conducted with secondary data from the previous study. Study was conducted in three hospitals in Jakarta, namely Cipto Mangunkusumo General Hospital, Budhi Asih Hospital, …

Recurrent Perianal Wart Therapy With 90% Trichloroacetate (Tca) Solution In Aids Patients, Sri Linuwih Sw Menaldi, Ika Anggraini, Hanny Nilasari

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Being the most commonly found sexually-transmitted infection (STI), anogenital warts are mainly caused by human papilloma virus (HPV) type 6 and 11. These infections are often recurrent, leading to loss of time and medical expenses. Various therapeutic modalities can be chosen singularly or in combination with varying results. Treatments with less responsive results usually occur when acquired comorbidities are present, such as HIV infection.

Case Illustration: A 28-year-old homosexual male was reported to have a recurrent perianal wart for the duration of eight months. He was also diagnosed with AIDS and pulmonary tuberculosis. Initially, patient was treated …

Karakteristik Pasien Tuberkulosis Lost To Follow Up Dari Empat Rs Di Kota Bandung, Azizah Muthiah, Noormarina Indraswari, Budi Sujatmiko

Jurnal Epidemiologi Kesehatan Indonesia

Jumlah kasus tuberkulosis (TB) yang tidak terlaporkan dan tidak terdeteksi di Indonesia sebelum pelaksanaan sistem pengawasan TB nasional pada tahun 2017 mencapai 47% dari total kasus, termasuk di dalamnya kasus TBlost to follow up atau hilang dari pengamatan. Pasien yang termasuk dalam kelompok ini akan meningkatkan risiko perburukan klinis, kambuh, gagal pengobatan, dan menjadi resistan terhadap obat, selain itu mereka juga akan mejadi sumber penularan di masyarakat. Tujuan penelitian ini yaitu untuk mengetahui karakteristik pasien rawat jalan TB yang hilang dari pengamatan dari empat rumah sakit terpilih di Kota Bandung. Penelitian ini menggunakan studi deskriptif dengan rancangan potong lintang. Sampel …

Pengaruh Penerapan Healthcare Infection Control Practices Advisory Committee Terhadap Kejadian Infeksi Saluran Kemih Terkait Penggunaan Kateter, Wendy Isman Sitepu

Jurnal ARSI : Administrasi Rumah Sakit Indonesia

An estimated 0,2-4,8 Catheter-associated Urinary Tract Infection (CAUTI) cases 1.000 catheter-days affected around the world. CAUTI not only has affected the patient but also has became a burden on hospital. Many prevented CAUTI guidelines has developed, one of them is issued by Healthcare Infection Control Practices Advisory Committe (HICPAC). The study aimed to evaluate HICPAC guideline decreasing CAUTI rate. A quasi-experimental study was performed to ass’s effectiveness HICPAC guidelines with two group pretest-posttest approach patients with catheter 150 samples each. Before implementation, all medic staff was explained and trained about the guideline. All medical staff was assessed their knowledge, attitudes, …

Determinant Of Latent Pulmonary Tuberculosis Incidence Among Health Workers In Community Health Centers In Surabaya, Indonesia, Susilowati Andajani

Folia Medica Indonesiana

About 2 billion people in the world are infected with latent TB, and 5-10% of them will develop into active TB. The purpose of this study was to analyze the relationship between nutritional status, behavior, duration of work, comorbidities, and workplace ventilation with the incidence of latent pulmonary TB. This type of research is an observational cross sectional analytic, a sample of research of poly TB analysts and nurses from 13 health centers in Surabaya, a sample of 30 people. Statistical analysis with Chi Square and t-2 test samples were free with a=0.05. The results of this study are: The …

Dapsone Hypersensitivity Syndrome Overlaps Reversal Reaction In Leprosy Patient, Chesia Christiani Liuwan, Medhi Denisa, M Yulianto Listiawan

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Leprosy is a chronic granulomatous infectious disease that primarily involves the skin and peripheral nerve and is caused by Mycobacterium leprae. Clinical features may vary depending on the patient’s immune response. Reversal reaction due to increased immunity is common after treatment in patients with borderline leprosy. Dapsone hypersensitivity syndrome (DHS) is an adverse effect from dapsone therapy that may occur in 5-6 weeks to 6 months after initial treatment.

Case Illustration: A 47-year-old female complained of a spreading red patches on the skin of her trunk and extremities for three weeks duration. She also felt itchiness and …

Dengue Fever And The Discourse Of Blame: An Ethnographic Study In A Thai Village That Produces “Lucky Bamboo”, Pilasinee Wongnuch, Pimpawun Boonmongkon, Thomas E. Guadamuz

Asia-Pacific Social Science Review

This paper aims to investigate the dengue fever discourse and discursive practices in a Thai village that produces lucky bamboo in terms of the source of poor sanitary, vector breeding, site of transmission, and responses of those in the village. In particular, villagers who produce lucky bamboo have been blamed for the risk for dengue emergence in the community, despite having no cases of dengue fever. The study included 14 months of participant observation, ethnographic interviews with 19 lucky bamboo farmers, in-depth interviews with 69 villagers, semi-structured interviews with 10 local government officials, and a discourse analysis on international guidelines, …

Role Of Gp120 Glycosylation In Sexual Transmission Of Hiv, Yingxue Sun, Adam Meadows, Najwa Zebian, Eric Arts, Carole Creuzenet

Western Research Forum

Background:

In chronic HIV patients, the viral populations are genetically diverse due to mutations introduced by the viral reverse transcriptase during HIV replication. However, more than 80% new infections result from single transmission founder (TF) viruses; therefore, targeting the TFs is key to control AIDS worldwide.

Gp120 is a glycosylated envelope protein required for HIV infection, propagation, and transmission. Glycans on gp120 influence HIV infectivity through their interactions with lectins, the carbohydrate-binding immune proteins in the host mucosa. To transmit sexually, viruses must overcome the lectin traps to access more target T cells.

Hypothesis:

TF viruses are less likely to …

Prevalence And Correlates Of Diagnosed And Undiagnosed Hypertension In The Indigenous Kuna Population Of Panamá, Daniel R. Hanna, Rebekah J. Walker, Brittany L. Smalls, Jennifer A. Campbell, Aprill Z. Dawson, Leonard E. Egede

Center for Health Services Research Faculty Publications

Background: To determine the prevalence of hypertension and investigate sociodemographic correlates in an indigenous Kuna community living on the San Blas islands of Panama.

Methods: Data was collected from adults using a paper-based survey using a cross sectional study design. Blood pressure was measured, and hypertension defined at two cut-points: 130/80 mmHg and 140/90 mmHg. Individuals with undiagnosed hypertension had a blood pressure measurement that indicated hypertension, however, the individual had not been told by a doctor they had hypertension. Whereas individuals with diagnosed hypertension had been told by a healthcare provider that they had hypertension. Univariate tests compared diagnosed …

Gallstone Ileus In Cipto Mangunkusumo General Hospital, Jakarta: A Case Series, Toar Jm Lalisang, Georgina P. Hehuwat, Arnetta Nl Lalisang, Irfan K. Pratama, Yarman Mazni

The New Ropanasuri Journal of Surgery

Introduction. Gallstone ileus is an uncommon mechanical bowel obstruction caused by a gallstone in the gastrointestinal tract which enters due to bile-enteric fistulae. This study aims to describe gallstone ileus and its management. Method. Data were retrospectively collected from medical records. Clinical manifestations, laboratory data, supporting radiographic examinations, treatment, postoperative care, and outcomes were collected. Results. We report two gallstone ileus cases at Cipto Mangunkusumo General Hospital, Jakarta which admitted in the last 20 years. The first case was a woman 33 years in 2002 and the second was man 45 years in 2017. Ileus was the main clinical symptoms. …

The Role Of The Community Health Delivery System In The Health And Well-Being Of Justice-Involved Women: A Narrative Review, Sharla A. Smith, Glen P. Mays, Tracie C. Collins, Megha Ramaswamy

Health Management and Policy Faculty Publications

Background: Over seven million imprisoned and jailed women are released into the community each year and many are ill-equipped to meet the challenges of re-integration. Upon release into their community, women are faced with uncertain barriers and challenges using community services to improve their health and well-being and reuniting with families. Few studies have identified and described the barriers of the community health delivery system (CHDS)- a complex set of social, justice, and healthcare organizations that provide community services aimed to improve the health and well-being (i.e. safety, health, the success of integration, and life satisfaction) of justice-involved women. We …

Epilepsy Diagnosis And Management Of Children In Kenya: Review Of Current Literature, Pauline Samia, Jane Hassell, Jessica-Anne Hudson, Symon M. Kariuki, Charles R. Newton, Jo M. Wilmshurst

Paediatrics and Child Health, East Africa

Introduction: The growing impact of non-communicable diseases in low- to middle-income countries makes epilepsy a key research priority. We evaluated peer-reviewed published literature on childhood epilepsy specific to Kenya to identify knowledge gaps and inform future priorities.

Methodology: A literature search utilizing the terms “epilepsy” OR “seizure” as exploded subject headings AND “Kenya” was conducted. Relevant databases were searched, generating 908 articles. After initial screening to remove duplications, irrelevant articles, and publications older than 15 years, 154 papers remained for full-article review, which identified 35 publications containing relevant information. Data were extracted from these reports on epidemiology, etiology, clinical features, …

Progress On Effects Of Plant Polyphenols On Intestinal Microecology, Li Hao, Peng Xiyang, Wu Paixuan, Dai Zhiyong, Wang Jiaqi, Zhan Yanhong, He Xiangli

Food and Machinery

This paper discussed the regulation mechanism of plantpolyphenols on intestinal microecology, summarized and analyzed the effects of different kinds of polyphenols and mixed polyphenols extracts on the change of intestinal flora community structure, and prospected the research direction of plant polyphenols and the development of related products in the future.

Using A Bundle Care To Reduce The Infection Rate Of Multi-Drug Resistant Microorganisms, Shan-Ying Wu, Shia-Cheng Lin, Li-Chun Cheng

International Nursing Research Congress (INRC)

A number of multi drug resistant microorganisms (MDR) are gradually increasing in the world. The aim of this program is to apply a bundle care to reduce the infection rate of MDR in one cardiovascular surgery intensive care unit in Taiwan.

Translating Theory To Practice: Integrating Global Health Curricula And Healthcare Across Nations, Olivia Catolico, Jane Anyango, Leandra Wallace

International Nursing Research Congress (INRC)

This presentation highlights the integration of intercultural knowledge and translation of theory to practice in nursing curricula. Conference participants will be able to design a course or curriculum using global learning outcomes, and develop effective measures of learning appropriately leveled within the curriculum.

Outcomes Of Children Prenatally Exposed To Opioids Around The World: A Systematic Review, Sara J. Arter, Brian Tyler, Cameron M. Hay, Jennifer Mcallister, Elizabeth Kiel

International Nursing Research Congress (INRC)

Illicit use of opioids is becoming a global health concern, especially amongst users of childbearing age. In this session, long-term developmental outcomes of children around the world prenatally exposed to opioids will be discussed, as well as implications for future research and nursing practice.

Perceptions And Understanding Of Antibiotic Use With Caregivers Of School-Age Children, Angela Opsahl, Allyson Hunsinger, Nicholas Bell, Megan Eble, Emily Pedigo, Breanna Martlage, Desiree Hensel

International Nursing Research Congress (INRC)

Common caregiver viewpoints regarding antibiotic use in school-age children were analyzed utilizing Q-methodology. An educational in-service was conducted based on the findings to improve understanding of antibiotics. A pre- and post-test survey of participants was created to evaluate the effectiveness of the educational intervention.