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2019

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Ndikimi I Ndërrimit Të Natës Në Gjendjen Emocionale Të Infermierëve Në Qkmf-Në E Rahovecit, Sumera Kabashi Nov 2019

Ndikimi I Ndërrimit Të Natës Në Gjendjen Emocionale Të Infermierëve Në Qkmf-Në E Rahovecit, Sumera Kabashi

Theses and Dissertations

Ky studim adreson çështje të gjendjes emocionale në punë të infermierëve në Qendrën Kryesore të Mjekësisë Familjare të Rahovecit. Një model linear që lidh rolin në punë dhe faktorët shoqërorë, ankthin depresionin, dhe vetvlersimin.

Ky hulumtim është realizuar me 24 infermierë, ku 12 infermierë janë intervistuar gjatë ndërrimit të natës dhe 12 infermierë gjatë ndërrimit të ditës. Nga këta, 6 janë të gjinisë mashkullore apo 25%, dhe 18 të gjinisë femërore apo 75%. Mosha më e ulët e infermierëve ishte 32 vjeç, ndërsa më e larta 54 vjeç.

Ky studim synon të identifikojë provat shkencore mbi shfaqjen e ndryshimeve të …


Barnat Më Të Përdorura Në Urgjencën E Qendrës Së Mjeksisës Familjare Në Pozheran, Valmira Hoxha Nov 2019

Barnat Më Të Përdorura Në Urgjencën E Qendrës Së Mjeksisës Familjare Në Pozheran, Valmira Hoxha

Theses and Dissertations

Shëndeti i çdo pacienti ёshtё gjëja primare që çdo profesionist shëndetësor duhet ta ketë parasysh dhe tё tregojë njё kujdes tё veçantë. Unё si studente e degës sё infermierisë dëshiroj qё ta trajtoj kёtё çështje sa tё bukur po aq edhe delikate për tё zgjeruar njohurit e mia si dhe ti’u tregoj se cilat janë parimet bazë të punës në Urgjencen e QMF- Pozheran .

Kudo që аplikohet kujdesi ndаj pаcientëve, përbërësi kryesor i tij është cilësiа që personeli shëndetësor sjell tek pаcientёt, mënyrа e kujdesit që bën të mundur dаllimin e nevojаve të pаcientit dhe fаmiljes, nevojаve që zhvillohen …


Promovimi Dhe Edukimi Shëndetësor Për Hiv Tek Të Rinjtë E Moshës 16-17 Vjeç, Shehale Koraqi Nov 2019

Promovimi Dhe Edukimi Shëndetësor Për Hiv Tek Të Rinjtë E Moshës 16-17 Vjeç, Shehale Koraqi

Theses and Dissertations

Ky punim teoriko-empirik përfshinë një problematikë të njohur për sistemin shëndetësor dhe tek shumica e individëve të moshës madhore. Karakteristikat esenciale të kësaj sëmundje mund të paraqiten si në vijim: nyjat limfatikë të fryra, fillimi i humbjes së peshës, ndjenja e plogështisë (lodhjes ekstreme) ethet, dhembja e fytit dhe kokës, dhimbje të muskujve, që paraqiten tek të gjitha nivelet e moshave. Ky hulumtim me temë “Promovimi dhe edukimi shëndetësor për HIV tek të rinjtë e moshës 16-17 vjeç”, kërkon të vërtetojë natyrën e ndërlidhjes mes moshave të paraqitura si në titull të temës, pra moshat rinore, njohuritë e tyre, …


Kujdesi I Infermieror Ne Trajtimin E Leukemise, Sadber Popaj Nov 2019

Kujdesi I Infermieror Ne Trajtimin E Leukemise, Sadber Popaj

Theses and Dissertations

Cilësia e kujdesit infermieror është një element thelbësor në trajtimin e pacientit me leukemi në njësitë e kujdesit ditor apo edhe ne njesite e hospitalizimit. Qëllimi i këtij studimi eshte të zbulojë gatishmërinë e infermierëve për të siguruar kujdesin infermieror tek pacientët me leukemi ne QKUK ne Departamentin e Onkologjise duke hetuar nëse infermieret që punojnë me pacientë me leukemi kanë njohuri të mjaftueshme për kujdesin ndaj leukemise. Një qëllim tjetër ishte marrja në pyetje nivelet e ekspertizës së personelit infermieror në kujdesin për leukemine.Hulumtimi u krye në Qendren Klinike Universitare te Kosoves ne Departamentin e Onkologjise me gjithsej 32 …


Automatic Lung Cancer Detection Using Artificial Intelligence, Bardh Rushiti Nov 2019

Automatic Lung Cancer Detection Using Artificial Intelligence, Bardh Rushiti

Theses and Dissertations

By far, lung cancer is the prominent cause of cancer deaths for both men and women around the world. In 2018, statistics for WCRF (Worldwide Cancer Research Fund) showed that out of 2.09 million people diagnosed with this disease, 1.76 million people died. The survival rate increases if detected in its earlier stages. Taking into consideration the complexity of the problem, many computer-aided diagnosis systems that increase the survival rate have been proposed and developed. Driven by the notable success of deep learning in the area of complex image classification problems, this paper presents the use of VGG16, VGG19, ResNet34, …


Përdorimi I Mbetjeve Të Newco Ferronikeli Në Prodhimin E Betonit, Armend Shabani Nov 2019

Përdorimi I Mbetjeve Të Newco Ferronikeli Në Prodhimin E Betonit, Armend Shabani

Theses and Dissertations

Industritë si ajo e përfitimit të metaleve dhe ato të produkteve të ndërtimit gjatë këtij shekulli kanë avancuar shumë me skemat dhe tekonologjitë e tyre prodhuese, duke vënë për objektiv kyç; shfrytëzimin efiçient të resurseve, përmirësimin e vetive të materialeve, rentabilitetin prodhues dhe sjellje të përgjegjshme ndaj mjedisit. Megjithatë, në vendin tonë ekzistojnë industri si ajo e ,,Ferronikelit’’ në Drenas të cilat ende vazhdojnë me skema prodhuese të cilat pamundësojnë shfrytëzimin e mes-produketeve, duke i shëndrruar ato në mbetje të cilat tani më janë një problem mjedisor. Në këtë temë të diplomës, kemi dashur të theksojmë se duke shtuar një …


Rigjenerimi Përbrenda Mureve Antike Në Qytetin E Vjetër Të Kotorrit, Alina Ahmeti Nov 2019

Rigjenerimi Përbrenda Mureve Antike Në Qytetin E Vjetër Të Kotorrit, Alina Ahmeti

Theses and Dissertations

Kishte kaluar një periudhë e gjatë kohore prej që e kisha vizituar për të fundit herë Qytetin e Vjetër të Kotorrit. Kështu, vendosa të shkoj për një vizitë tre ditore në fundjavën e datëlindjes sime. Me këtë rast zbulova se shumë gjëra kishin ndryshuar prej që kisha qenë herën e fundit. Meqenëse isha studente e Arkitekturës, mënyra se si e shihja këtë qytet tani, në sytë e mi, ishte ndryshe nga përjetimet e kaluara dhe përfundimisht më e veçantë se kurrë. Mu kujtua gjyshi im shumë i dashur, tashmë i ndjerë, i cili më rrëfente historinë e shqiptarëve, që e …


Immunohistochemical And Molecular Features Of Melanomas Exhibiting Intratumor And Intertumor Histomorphologic Heterogeneity, Haider A. Mejbel, Sri Krishna C. Arudra, Dinesh Pradhan, Carlos A. Torres-Cabala, Priyadharsini Nagarajan, Michael T. Tetzlaff, Jonathan L. Curry, Doina Ivan, Dzifa Y. Duose, Raja Luthra, Victor G. Prieto, Leomar Y. Ballester, Phyu P. Aung Nov 2019

Immunohistochemical And Molecular Features Of Melanomas Exhibiting Intratumor And Intertumor Histomorphologic Heterogeneity, Haider A. Mejbel, Sri Krishna C. Arudra, Dinesh Pradhan, Carlos A. Torres-Cabala, Priyadharsini Nagarajan, Michael T. Tetzlaff, Jonathan L. Curry, Doina Ivan, Dzifa Y. Duose, Raja Luthra, Victor G. Prieto, Leomar Y. Ballester, Phyu P. Aung

ETSU Faculty Works

Melanoma is a heterogeneous neoplasm at the histomorphologic, immunophenotypic, and molecular levels. Melanoma with extreme histomorphologic heterogeneity can pose a diagnostic challenge in which the diagnosis may predominantly rely on its immunophenotypic profile. However, tumor survival and response to therapy are linked to tumor genetic heterogeneity rather than tumor morphology. Therefore, understating the molecular characteristics of such melanomas become indispensable. In this study, DNA was extracted from 11 morphologically distinct regions in eight formalin-fixed, paraffin-embedded melanomas. In each region, mutations in 50 cancer-related genes were tested using next-generation sequencing (NGS). A tumor was considered genetically heterogeneous if at least one …


Diversity In Party Leadership In State Legislatures, Eric Hansen, Christopher J. Clark Nov 2019

Diversity In Party Leadership In State Legislatures, Eric Hansen, Christopher J. Clark

Political Science: Faculty Publications and Other Works

Members of historically underrepresented groups—women, African Americans, Latinos, and workers—are serving in American legislatures in increasing numbers. However, legislators wield substantially greater power in the lawmaking process when they hold leadership positions. Incorporation of these groups into leadership positions could indicate fuller political representation, but scholars to date have not assessed how well these groups are represented in leadership. We analyze original data describing the backgrounds of approximately 2,200 leaders in 30 states between 2003 and 2014. The data show that, on average across states, members of these groups are as well represented in state legislative leadership positions as they …


2019-November-01-Etsu’S Pack Chaired National Task Force On Opioid Crisis, University Marketing And Communications, East Tennessee State University Nov 2019

2019-November-01-Etsu’S Pack Chaired National Task Force On Opioid Crisis, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.


2019-2020 Spring Bulletin, University Of Mississippi Medical Center Nov 2019

2019-2020 Spring Bulletin, University Of Mississippi Medical Center

Bulletins/Catalogs

2019-2020 Spring Bulletin


The Role Of The School Principal In The Implementation Of Education Reforms, Esther Mumbua Mbondo Nov 2019

The Role Of The School Principal In The Implementation Of Education Reforms, Esther Mumbua Mbondo

Master of Education

This study sought to investigate how school principals implement education reforms in Kenya. It focused on the main roles of school principals in the implementation of national education reforms, the factors that support them during the implementation, and the challenges that hinder them and the strategies they devise to mitigate the challenges. The study adopted a qualitative approach a case study design. It used a purposively selected sample of 18 participants from two secondary schools in Mombasa County, Kenya. Data for this study was gathered by individual interviews, focus group discussions and document analysis. Study findings show that the school …


The Role Of Peer Mentoring In Influencing The Teaching Practices In Secondary Schools: A Case Study Of Millennial High School In Kampala, Uganda, Ibrahim Mutebi Nov 2019

The Role Of Peer Mentoring In Influencing The Teaching Practices In Secondary Schools: A Case Study Of Millennial High School In Kampala, Uganda, Ibrahim Mutebi

Master of Education

Peer mentorship is currently considered to be an effective means of continuous professional development for teachers in schools. It is believed to enhance teaching practices in schools because it facilitates an environment where peers willingly support and learn from each other. However, to create a culture that enhances reciprocal learning and peer scaffolding, there is need for a paradigm shift in what stakeholders believe about teachers capabilities in enhancing each other’s teaching practices within the school context. The belief that peer mentoring creates a thriving teaching practice and motivated teachers informed this study which explored how peer mentorship influences teachers’ …


Bring Your Own Device (Byod): Engaging High School Students In A Photovoice Project On School Health Promotion Using Their Own Smart Devices In Nakuru North Of Nakuru County, Kenya, Francis Wacieni Mureithi Nov 2019

Bring Your Own Device (Byod): Engaging High School Students In A Photovoice Project On School Health Promotion Using Their Own Smart Devices In Nakuru North Of Nakuru County, Kenya, Francis Wacieni Mureithi

Master of Education

The Bring Your Own Device (BYOD) initiative has in the recent years gained popularity globally where smart devices have become the bridge to close the digital divide in ICT integration in schools, enhanced individualized learning and expanded collaborations. Despite its proven efficacy in transforming learning and teaching, efforts to shift to BYOD is still very slow in developing countries. This is due to negative perceptions of stakeholders, among several other factors; teachers and parents do not trust that students can remain focused on education and be self-disciplined when using their smart devices in public schools in Kenya. The purpose of …


Average Speech Directivity, Samuel D. Bellows, Claire M. Pincock, Jennifer K. Whiting, Timothy W. Leishman Nov 2019

Average Speech Directivity, Samuel D. Bellows, Claire M. Pincock, Jennifer K. Whiting, Timothy W. Leishman

Directivity

Speech directivity describes the angular dependence of acoustic radiation from a talker’s mouth and nostrils and diffraction about his or her body and chair (if seated). It is an essential physical aspect of communication affecting sounds and signals in acoustical environments, audio, and telecommunication systems. Because high-resolution, spherically comprehensive measurements of live, phonetically balanced speech have been unavailable in the past, the authors have undertaken research to produce and share such data for simulations of acoustical environments, optimizations of microphone placements, speech studies, and other applications. The measurements included three male and three female talkers who repeated phonetically balanced passages …


Vimentin Protects Cells Against Nuclear Rupture And Dna Damage During Migration, Alison E. Patteson, Amir Vahabikashi, Katarzyna Pogoda, Stephen A. Adam, Kalpana Mandal, Mark Kittisopikul, Suganya Sivagurunathan, Anne Goldman, Robert D. Goldman, Paul A. Janmey Nov 2019

Vimentin Protects Cells Against Nuclear Rupture And Dna Damage During Migration, Alison E. Patteson, Amir Vahabikashi, Katarzyna Pogoda, Stephen A. Adam, Kalpana Mandal, Mark Kittisopikul, Suganya Sivagurunathan, Anne Goldman, Robert D. Goldman, Paul A. Janmey

Physics - All Scholarship

Mammalian cells frequently migrate through tight spaces during normal embryogenesis, wound healing, diapedesis, or in pathological situations such as metastasis. Nuclear size and shape are important factors in regulating the mechanical properties of cells during their migration through such tight spaces. At the onset of migratory behavior, cells often initiate the expression of vimentin, an intermediate filament protein that polymerizes into networks extending from a juxtanuclear cage to the cell periphery. However, the role of vimentin intermediate filaments (VIFs) in regulating nuclear shape and mechanics remains unknown. Here, we use wild-type and vimentin-null mouse embryonic fibroblasts to show that VIFs …


Unequal Opportunities And Public Policy: The Impact Of Parental Disability Benefits On Child Postsecondary Attendance, Kelly Chen, Lars Osberg, Shelley Phipps Nov 2019

Unequal Opportunities And Public Policy: The Impact Of Parental Disability Benefits On Child Postsecondary Attendance, Kelly Chen, Lars Osberg, Shelley Phipps

Economics Faculty Publications and Presentations

This paper uses Canada’s National Longitudinal Survey of Children and Youth to examine whether greater cash transfers available to parents with disabilities when their child was aged 5 to 15 increase the chances that the child will attend post-secondary education (PSE) as a young adult. We exploit differences across provinces and over time in the generosity of provincial disability benefits programs in Canada and find that higher disability benefits when the child was aged 5-15 years old increase the probability that he or she will have attended or be attending PSE by age 19 to 25. The estimated effect size …


Effect Of A 24-Week Randomized Trial Of An Organic Produce Intervention On Pyrethroid And Organophosphate Pesticide Exposure Among Pregnant Women, Cynthia L. Curl, Jessica Porter, Ian Penwell, Rachel Phinney, Marai Ospina, Antonia M. Calafat Nov 2019

Effect Of A 24-Week Randomized Trial Of An Organic Produce Intervention On Pyrethroid And Organophosphate Pesticide Exposure Among Pregnant Women, Cynthia L. Curl, Jessica Porter, Ian Penwell, Rachel Phinney, Marai Ospina, Antonia M. Calafat

Public and Population Health Faculty Publications and Presentations

Background: Introduction of an organic diet can significantly reduce exposure to some classes of pesticides in children and adults, but no long-term trials have been conducted. Objectives: To assess the effect of a long-term (24-week) organic produce intervention on pesticide exposure among pregnant women.

Methods: We recruited 20 women from the Idaho Women, Infants, and Children (WIC) program during their first trimester of pregnancy. Eligible women were nonsmokers aged 18–35 years who reported eating exclusively conventionally grown food. We randomly assigned participants to receive weekly deliveries of either organic or conventional fruits and vegetables throughout their second or third trimesters …


Addressing Challenges To The Reliable, Large-Scale Implementation Of Effective School Health Education, Michael J. Mann, David K. Lohrmann Nov 2019

Addressing Challenges To The Reliable, Large-Scale Implementation Of Effective School Health Education, Michael J. Mann, David K. Lohrmann

Public and Population Health Faculty Publications and Presentations

The long-held priority of teaching young people the knowledge and skills needed for healthy living has recently been diminished in many preK-12 schools. Driven by federal and state priorities, laws, and policies associated with high-stakes testing, instruction in untested subjects has been reduced or eliminated in most schools in order to devote more attention to tested subjects, like reading, math, writing, and science. This article proposes a pathway to ensure that all children are able to learn what society knows about health. To that end, four challenges to the reliable, large-scale implementation of effective school health education are identified: (1) …


The American West As A Social-Ecological Region: Drivers, Dynamics And Implications For Nested Social-Ecological Systems, Jodi Brandt, Matthew A. Williamson Nov 2019

The American West As A Social-Ecological Region: Drivers, Dynamics And Implications For Nested Social-Ecological Systems, Jodi Brandt, Matthew A. Williamson

Human-Environment Systems Research Center Faculty Publications and Presentations

The American West exists in the popular imagination as a distinct region, and policies and politics often suggest that both the challenges and the opportunities for land management and human well-being across the region are relatively homogeneous. In this paper, we argue that there are key characteristics that define the West as a social-ecological region, and also that there are myriad social-ecological systems (SESs) within the region that require diverse and dynamic approaches to managing change over time. We first conceptualize aridity, topography, and a unique political economy of land as exogenous factors that persist over time and space to …


Resource Characterisation Of Personal-Scale Sensing Models On Edge Accelerators, Mattia Antonini, Tran Huy Vu, Chulhong Min, Alessandro Montanari, Akhil Mathur, Fahim Kawsar Nov 2019

Resource Characterisation Of Personal-Scale Sensing Models On Edge Accelerators, Mattia Antonini, Tran Huy Vu, Chulhong Min, Alessandro Montanari, Akhil Mathur, Fahim Kawsar

Student Publications

Edge accelerator is a class of brand-new purpose-built System On a Chip (SoC) for running deep learning models efficiently on edge devices. These accelerators offer various benefits such as ultra-low latency, sensitive data protection, and high availability due to their locality and are opening up interminable opportunities for building sensory systems in the real world. Naturally, in the context of sensory awareness systems, e.g., IoT, wearables, and other sensory devices, the emergence of edge accelerators is pushing us to rethink how we design these systems at a personal-scale. To this end, in this paper we take a closer look at …


Academic Librarians Serving Diverse Populations Of Multilingual Students, Alexandra A. De Luise, Kanu A. Nagra, Bernadette M. López-Fitzsimmons, Michael W. Handis, Jeremy Czerw Nov 2019

Academic Librarians Serving Diverse Populations Of Multilingual Students, Alexandra A. De Luise, Kanu A. Nagra, Bernadette M. López-Fitzsimmons, Michael W. Handis, Jeremy Czerw

Publications and Research

A group of academic librarians working in community and four-year colleges, graduate programs and other settings present strategies and approaches for serving diverse multilingual populations. Multilingual students improve their awareness and understanding of United States academic libraries and higher education when librarians are cognizant of their needs. Encounters can occur at the research desk, in classroom instruction, and during research consultations. Also included are tips on how academic librarians can assist multilingual and international students, including how to improve communication. Based on an ACRL 2019 panel discussion of the same title.


Radical Technological Innovation And Perception: A Non-Physician Practitioners’ Perspective, Mercedes Maarup, Michael Dohan, Wenyao Zhao, Shikui Wu Nov 2019

Radical Technological Innovation And Perception: A Non-Physician Practitioners’ Perspective, Mercedes Maarup, Michael Dohan, Wenyao Zhao, Shikui Wu

Transactions of the International Conference on Health Information Technology Advancement

Radical technological innovations, such as chatbots, fundamentally alter many aspects of healthcare organizations. For example, they transform how clinicians care for their patients. Despite the potential benefits, they cannot be integrated into practice without the support of the clinicians whose jobs are affected. While previous research shed important light on physicians’ perceptions, little is known on nonphysician practitioners view said innovations. This paper reports on a qualitative study, involving 10 nonphysician clinicians from Ontario, Canada, conducted to determine the perceptions and cognitions of clinicians regarding radical innovation and their previous experiences with technological change. Results indicate that clinicians as semi-autonomous …


Transactions Of 2019 International Conference On Health Information Technology Advancement Vol. 4 No. 1, Center For Health Information Technology Advancement Nov 2019

Transactions Of 2019 International Conference On Health Information Technology Advancement Vol. 4 No. 1, Center For Health Information Technology Advancement

Transactions of the International Conference on Health Information Technology Advancement

The Fourth International Conference on Health Information Technology Advancement Kalamazoo, Michigan, October 31 - Nov. 1, 2019.

Conference Co-Chairs Bernard T. Han and Muhammad Razi, Department of Business Information Systems, Haworth College of Business, Western Michigan University Kalamazoo, MI 49008

Transaction Editor Dr. Huei Lee, Professor, Department of Computer Information Systems, Eastern Michigan University Ypsilanti, MI 48197

Volume 4, No. 1

Hosted by The Center for Health Information Technology Advancement, WMU


End-Point Modification Of Recombinant Thrombomodulin With Enhanced Stability And Anticoagulant Activity, Xia Liu, Mallorie Boron, Yu Zhao, Xue-Long Sun Nov 2019

End-Point Modification Of Recombinant Thrombomodulin With Enhanced Stability And Anticoagulant Activity, Xia Liu, Mallorie Boron, Yu Zhao, Xue-Long Sun

Chemistry Faculty Publications

Thrombomodulin (TM) is an endothelial cell membrane protein that plays essential roles in controlling vascular haemostatic balance. The 4, 5, 6 EGF-like domain of TM (TM456) has cofactor activity for thrombin binding and subsequently protein C activation. Therefore, recombinant TM456 is a promising anticoagulant candidate but has a very short half-life. Ligation of poly (ethylene glycol) to a bioactive protein (PEGylation) is a practical choice to improve stability, extend circulating life, and reduce immunogenicity of the protein. Site-specific PEGylation is preferred as it could avoid the loss of protein activity resulting from nonspecific modification. We report herein …


Privacy As Pretext, Susan Hazeldean Nov 2019

Privacy As Pretext, Susan Hazeldean

Faculty Scholarship

No abstract provided.


Exploring Teaching And Learning Of Chemistry Concepts: A Case Study Of A Secondary School In Kenya, Beatrice Adhiambo Okech Nov 2019

Exploring Teaching And Learning Of Chemistry Concepts: A Case Study Of A Secondary School In Kenya, Beatrice Adhiambo Okech

Master of Education

The purpose of this study was to explore teaching and learning of chemistry concepts in the secondary schools in Kenya. The study adopted a paradigm where a qualitative research approach and a single case study were used. The study was done in a secondary school in Kisumu County, Kenya. The study used face to face interviews with teachers and students as primary research instrument while classroom observations and document analysis supplemented the interviews. The findings reveal that although five strategies were used for teaching and learning of chemistry concepts, there are those that learners preferably enjoy and like when used …


An Exploration On How Teen Mothers Cope With Mothering And Schooling, Maxphiler Jepkosgei Rotich Nov 2019

An Exploration On How Teen Mothers Cope With Mothering And Schooling, Maxphiler Jepkosgei Rotich

Master of Education

Adolescent pregnancy and motherhood have been given considerable attention in the Kenyan education system. Much attention , research and funding is dedicated to teen pregnancy prevention and abstinence –only education, yet many teens still become pregnant each year. Nevertheless, the Kenyan re-entry policy of 1994 allows these learners to continue with their education amidst other factors determining the completion of their studies. The purpose of this study was to find out how teen mothers cope with the demands of going to school and at the same time being mothers of their own children. Specifically, this study took an in depth …


Exploring The Use Of Assessment For Learning In Mathematics Teaching And Learning: A Case Study Of One Secondary School In Temeke Municipal Dsm, Tanzania, Selemani Said Mdee Nov 2019

Exploring The Use Of Assessment For Learning In Mathematics Teaching And Learning: A Case Study Of One Secondary School In Temeke Municipal Dsm, Tanzania, Selemani Said Mdee

Master of Education

This study explored the use of assessment for learning (AfL) in mathematics teaching and learning in one of secondary schools in Temeke Municipal in Dar es Salaam Tanzania. The study was guided by four subsidiary questions which are: to what extent teachers clarify learning intention and share criteria for success to students and what techniques teachers use to elicit evidence of learning. The other questions were, how secondary school learners are activated as an instructional resource for one another during teaching and learning and finally, what are the methods secondary school teachers use to provide feedback that moves learning forward. …


Human Monoclonal Antibodies Against Chikungunya Virus Target Multiple Distinct Epitopes In The E1 And E2 Glycoproteins, Jose A. Quiroz, Ryan J. Malonis, Larissa B. Thackray, Courtney A. Cohen, Jesper Pallesen, Rohit K. Jangra, Rebecca S. Brown, Daniel Hofmann, Frederick W. Holtsberg, Sergey Shulenin, Elisabeth K. Nyakatura, Lorellin A. Durnell, Vinayak Rayannavar, Johanna P. Daily, Andrew B. Ward, M. Javad Aman, John M. Dye, Kartik Chandran, Michael S. Diamond, Margaret Kielian, Jonathan R. Lai Nov 2019

Human Monoclonal Antibodies Against Chikungunya Virus Target Multiple Distinct Epitopes In The E1 And E2 Glycoproteins, Jose A. Quiroz, Ryan J. Malonis, Larissa B. Thackray, Courtney A. Cohen, Jesper Pallesen, Rohit K. Jangra, Rebecca S. Brown, Daniel Hofmann, Frederick W. Holtsberg, Sergey Shulenin, Elisabeth K. Nyakatura, Lorellin A. Durnell, Vinayak Rayannavar, Johanna P. Daily, Andrew B. Ward, M. Javad Aman, John M. Dye, Kartik Chandran, Michael S. Diamond, Margaret Kielian, Jonathan R. Lai

Open Access Publications

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes persistent arthritis in a subset of human patients. We report the isolation and functional characterization of monoclonal antibodies (mAbs) from two patients infected with CHIKV in the Dominican Republic. Single B cell sorting yielded a panel of 46 human mAbs of diverse germline lineages that targeted epitopes within the E1 or E2 glycoproteins. MAbs that recognized either E1 or E2 proteins exhibited neutralizing activity. Viral escape mutations localized the binding epitopes for two E1 mAbs to sites within domain I or the linker between domains I and III; and for two …