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2019

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Articles 63751 - 63780 of 65574

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Evaluation Of The Retinal Nerve Fiber Layer And Ganglion Cell Complex Thicknesses In Patients With Exfoliation Syndrome, Cem Alay, Oya Tekeli̇, Özge Yanik Odabaş, Feyza Çaliş Karanfi̇l Jan 2019

Evaluation Of The Retinal Nerve Fiber Layer And Ganglion Cell Complex Thicknesses In Patients With Exfoliation Syndrome, Cem Alay, Oya Tekeli̇, Özge Yanik Odabaş, Feyza Çaliş Karanfi̇l

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses using spectral domain optical coherence tomography (SD-OCT) in both unilateral and bilateral exfoliation syndrome (XFS) patients.Materials and methods: Twenty-four patients with unilateral XFS, 20 patients with bilateral XFS, and 23 healthy subjects were enrolled in this study. Eyes with XFS were compared with both fellow eyes and age-matched control subject eyes in terms of mean and segmental RNFL thickness and minimum, mean, and segmental GCC thickness. Results: In the bilateral XFS group, minimum GCC of the right eye (75.80 ± 11.6 μm) was …

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Risk Factors For Rectal Colonization Of Carbapenem-Resistant Enterobacteriaceae In A Tertiary Care Hospital: A Case-Control Study From Turkey, Fatma Eser, Gülruhsar Yilmaz, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fatma Yekta Ürkmez Korkmaz, Zi̇yaci̇bali̇ Açikgöz, Mehmet Akin Taşyaran Jan 2019

Risk Factors For Rectal Colonization Of Carbapenem-Resistant Enterobacteriaceae In A Tertiary Care Hospital: A Case-Control Study From Turkey, Fatma Eser, Gülruhsar Yilmaz, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Fatma Yekta Ürkmez Korkmaz, Zi̇yaci̇bali̇ Açikgöz, Mehmet Akin Taşyaran

Turkish Journal of Medical Sciences

Background/aim: This study aimed to evaluate the risk factors of patients colonized with carbapenem-resistant Enterobacteriaceae (CRE).Materials and methods: The study was conducted between January 2010 and March 2016. The colonized group consisted of patients who had a CRE strain in their rectal swab cultures, whereas patients with negative rectal surveillance cultures for CRE who were concurrently hospitalized in the same units with the colonized group patients were included in the control group.Results: The number of patients in the colonized and the control group was 71 and 120, respectively. Both groups were evaluated for demographic and healthcare-associated characteristics. Isolated microorganisms in …

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Effects Of Ankaferd Hemostat On Helicobacter Pylori Strains And Antibiotic Resistance, Rafi̇ye Çi̇ftçi̇ler, Ahmet Koluman, İbrahi̇m Celaletti̇n Haznedaroğlu, Nejat Akar Jan 2019

Effects Of Ankaferd Hemostat On Helicobacter Pylori Strains And Antibiotic Resistance, Rafi̇ye Çi̇ftçi̇ler, Ahmet Koluman, İbrahi̇m Celaletti̇n Haznedaroğlu, Nejat Akar

Turkish Journal of Medical Sciences

Background/aim: Ankaferd hemostat (ABS; Ankaferd blood stopper, İstanbul, Turkey) is a folkloric medicinal plant extract. The aim of this study was to determine the effect of Ankaferd hemostat (ABS) on the fate of Helicobacter pylori strains. The study also aims to determine alterations in the antimicrobial resistance of three different H. pylori strains in response to ABS exposure.Materials and methods: H. pylori Strain 1 was obtained from the culture collection ATCC 43504 and passaged three times for viability. Strain 2 was isolated from a gastric ulcer patient and Strain 3 was isolated from a gastritis patient. 1% of ABS was …

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Factors Associated With Glomerular Filtration Rate Variation In Primary Hyperparathyroidism After Parathyroidectomy, Mustafa Çalişkan, Muhammed Kizilgül, Selvi̇han Beysel, Beki̇r Uçan, Fati̇h Alper Akcan, Mümtaz Takir, Mustafa Özbek, Erman Çakal Jan 2019

Factors Associated With Glomerular Filtration Rate Variation In Primary Hyperparathyroidism After Parathyroidectomy, Mustafa Çalişkan, Muhammed Kizilgül, Selvi̇han Beysel, Beki̇r Uçan, Fati̇h Alper Akcan, Mümtaz Takir, Mustafa Özbek, Erman Çakal

Turkish Journal of Medical Sciences

Background/aim: Prolonged hypercalcemia impairs renal function, and a reduced glomerular filtration rate (GFR) is typical in advanced primary hyperparathyroidism (PHPT). There are scarce data related to predictors of renal impairment in patients with PHPT. Hence, we aimed to evaluate changes in kidney function in PHPT patients after parathyroidectomy (PTX) and identify factors associated with GFR variation in these patients.Materials and methods: One hundred and twenty-five patients with PHPT who underwent surgery between 2012 and 2014 were enrolled in the study. Patients were divided into two groups according to GFR values: patients whose GFR was lower than 60 mL/min/1.73 m2 and …

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Anticandidal Activities Of Lactic Acid Bacteria Isolated From The Vagina, Sevda Er, Ayşe İstanbullu Tosun, Gi̇zem Arik Berk, Meri̇h Kivanç Jan 2019

Anticandidal Activities Of Lactic Acid Bacteria Isolated From The Vagina, Sevda Er, Ayşe İstanbullu Tosun, Gi̇zem Arik Berk, Meri̇h Kivanç

Turkish Journal of Medical Sciences

Background/aim: Lactic acid bacteria prevent the overgrowth of pathogenic agents and opportunistic pathogens in the vagina. Moreover, lactic acid bacteria contribute to the preservation of vaginal microbiota by producing antimicrobial agents. Previous studies showed that some lactic acid bacteria exhibited antimicrobial activity against Candida species causing yeast vaginosis as well as many bacterial pathogens.Materials and methods: The antifungal activities of various lactic acid bacteria isolated from the vagina of healthy women on some Candida species isolated from the vagina were investigated by agar diffusion technique. Results: Most of the lactic acid bacteria that belong to the species of Lactobacillus crispatus, …

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Serum Fetuin-A Is Associated With The Components Of Miac(Malnutrition, Inflammation, Atherosclerosis, Calcification) Syndrome In Different Stages, Rüya Mutluay, Ceyla Konca Değerteki̇n, Emel Işiktaş Sayilar, Ülver Deri̇ci̇, Serap Gülteki̇n, Sevi̇m Gönen, Seli̇m Turgay Arinsoy, Mahmut Şükrü Si̇ndel Jan 2019

Serum Fetuin-A Is Associated With The Components Of Miac(Malnutrition, Inflammation, Atherosclerosis, Calcification) Syndrome In Different Stages, Rüya Mutluay, Ceyla Konca Değerteki̇n, Emel Işiktaş Sayilar, Ülver Deri̇ci̇, Serap Gülteki̇n, Sevi̇m Gönen, Seli̇m Turgay Arinsoy, Mahmut Şükrü Si̇ndel

Turkish Journal of Medical Sciences

Background/aim: Fetuin-A, a circulating inhibitor of calcification, is a marker of inflammatory-nutritional state. We evaluated the association between serum fetuin-A levels and vascular calcification, intima-media thickness, and nutritional and inflammatory markers in different stages of chronic kidney disease (CKD). Materials and methods: CKD patients were sampled for calcium-phosphate parameters and nutritional and inflammatory markers [highly sensitive C-reactive protein (hs-CRP)], and serum fetuin-A levels. Intima-media thicknesses of the common carotid arteries (CIMT) were measured. Peripheral artery calcification scores were obtained.Results: A total of 238 patients were included in the study. Fetuin-A levels in patients with end-stage renal disease were significantly lower …

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S1pr2 Deficiency Enhances Neuropathic Pain Induced By Partial Sciatic Nerve Ligation, Qiang Gu, Jin Chao Hou, Xiang Ming Fang Jan 2019

S1pr2 Deficiency Enhances Neuropathic Pain Induced By Partial Sciatic Nerve Ligation, Qiang Gu, Jin Chao Hou, Xiang Ming Fang

Turkish Journal of Medical Sciences

Background/aim: Sphingosine 1-phosphate receptor 2 (S1PR2), a member of the seven-transmembrane receptor family, can be activated by its natural ligand sphingosine 1-phosphate (S1P) to initiate signal transduction and is involved in a wide range of biological effects such as immune cell migration and vascular permeability. Its relationship with neuropathic pain (NP) has not been reported. In this study, the effects of S1PR2 on the development of NP were studied.Materials and methods: We generated a model of NP by partial sciatic nerve ligation (pSNL). The 50% paw withdrawal threshold of the wild-type (WT) group and the S1PR2 deficiency group were measured …

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Virulence Factors And Antimicrobial Resistance In Uropathogenic Escherichiacoli Strains Isolated From Cystitis And Pyelonephritis, Hosseinali Ghazvini, Keyvan Taheri, Elahe Edalati, Ali Miri, Mansour Sedighi, Shiva Mirkalantari Jan 2019

Virulence Factors And Antimicrobial Resistance In Uropathogenic Escherichiacoli Strains Isolated From Cystitis And Pyelonephritis, Hosseinali Ghazvini, Keyvan Taheri, Elahe Edalati, Ali Miri, Mansour Sedighi, Shiva Mirkalantari

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the prevalence of virulence genes as well as patterns of antibiotic resistance in cystitis and pyelonephritis uropathogenic Escherichia coli (UPEC) isolates. Materials and methods: Two hundred UPEC isolates were collected from hospitalized patients with pyelonephritis (n = 50) and cystitis (n = 150) in Shafa Hospital in Iran. Antimicrobial susceptibility and ESBL production were determined with confirmatory tests. Polymerase chain reaction assay was performed to determine the prevalence of virulence genes in UPEC strains. Results: Of a total 200 UPEC isolates, the highest and lowest resistance rates to antibiotics were for …

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About "Efficacy Of Bispectral Index Monitoring For Prevention Of Anesthetic Awareness And Complications During Oocyte Pick-Up Procedure", Ayşe Çi̇ğdem Tütüncü Jan 2019

About "Efficacy Of Bispectral Index Monitoring For Prevention Of Anesthetic Awareness And Complications During Oocyte Pick-Up Procedure", Ayşe Çi̇ğdem Tütüncü

Turkish Journal of Medical Sciences

No abstract provided.

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A Comparative Biomechanical Analysis Of Suprapectineal And Infrapectineal Fixation On Acetabular Anterior Column Fracture By Finite Element Modeling, Mehmet Yücens, Kadi̇r Bahadir Alemdaroğlu, Ahmet Özmeri̇ç, Serkan İltar, Ahmet Özgür Yildirim, Nevres Hürri̇yet Aydoğan Jan 2019

A Comparative Biomechanical Analysis Of Suprapectineal And Infrapectineal Fixation On Acetabular Anterior Column Fracture By Finite Element Modeling, Mehmet Yücens, Kadi̇r Bahadir Alemdaroğlu, Ahmet Özmeri̇ç, Serkan İltar, Ahmet Özgür Yildirim, Nevres Hürri̇yet Aydoğan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to compare the stability and implant stresses of suprapectineal plate with infrapectineal plate in three subconfigurations of the screw types. Materials and methods: The stabilities of different fixation methods were compared by finite element analysis on six models. Three infrapectineal and three suprapectineal models each with locked, unlocked, or combined screws were employed. Three-dimensional finite element stress analysis was performed by using isotropic materials with a load of 2.3 kN applied at standing positions. Motion at the fracture line was measured on four different points located on the pubic and iliac sides of …

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Cloning And Molecular Characterization Of Thiol-Specific Antioxidant Gene Of Leishmania Tropica Turkey Isolate, Hamza Özavci, Mustafa Kaplan Jan 2019

Cloning And Molecular Characterization Of Thiol-Specific Antioxidant Gene Of Leishmania Tropica Turkey Isolate, Hamza Özavci, Mustafa Kaplan

Turkish Journal of Medical Sciences

Background/aim: Thiol-specific antioxidant (TSA) protein is one of the most promising molecules among candidates for vaccine against cutaneous leishmaniasis. It was found to be significantly protective against different Leishmania species. In this study, cloning and molecular characterization of thiol-specific antioxidant gene of L. tropica Turkey isolate (LtTSA) were aimed. Materials and methods: LtTSA was amplified by PCR using the specific primers of TSA gene and cloned into the pcDNA3.1 vector. The cloning was confirmed by PCR screening, restriction enzyme reactions, and DNA sequence analysis. Finally, three-dimensional structure and antigenic properties of the protein encoded by the LtTSA were determined.Results: Six …

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Determining The Insulin Secretion Potential For Certain Specific G-Protein Coupled Receptors In Min6 Pancreatic Beta Cells, Hasan Gençoğlu, Kazi̇m Şahi̇n, Peter M. Jones Jan 2019

Determining The Insulin Secretion Potential For Certain Specific G-Protein Coupled Receptors In Min6 Pancreatic Beta Cells, Hasan Gençoğlu, Kazi̇m Şahi̇n, Peter M. Jones

Turkish Journal of Medical Sciences

Background/aim: The polypeptide hormone insulin is essential for the maintenance of whole-body fuel homeostasis, and defects in insulin secretion and/or action are associated with the development of type 1 and type 2 diabetes. The aim of this study was to assess the role of some G-protein coupled receptors (GPCRs), GPR54, GPR56, and GPR75, and cannabinoid receptors CB1R and CB2R, in the regulation of pancreatic ß-cell function.Materials and methods: Insulin secretion from mouse insulinoma ß-cell line (MIN6) monolayers was assessed via insulin radioimmu-noassay (RIA). Reverse transcription-polymerase chain reaction (RT-PCR) was used to assess the expression of some specific GPCRs and the …

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Mir-33 And Rip140 Participate In Lps-Induced Acute Lung Injury, Hua Li, Huan Hou, Shuang Liu, Yangyang Feng, Wansi Zhong, Xiaojuan Hu, Nianlong Yan Jan 2019

Mir-33 And Rip140 Participate In Lps-Induced Acute Lung Injury, Hua Li, Huan Hou, Shuang Liu, Yangyang Feng, Wansi Zhong, Xiaojuan Hu, Nianlong Yan

Turkish Journal of Medical Sciences

Background/aim: Pulmonary microvascular endothelial cells (PMVECs) play a pivotal role in the process of acute lung injury (ALI), which can be induced by lipopolysaccharide (LPS). Numerous reports have indicated that both miR-33 and RIP140 are involved in the inflammatory response in macrophages. In this study, we sought to investigate whether miR-33 and RIP140 participate in ALI induced by LPS.Materials and methods: First, we isolated and identified PMVECs from BALB/c mice. Subsequently, both PMVECs and BALB/c mice were treated with PBS, LPS, or pyrrolidine dithiocarbamate (PDTC) plus LPS and divided into three groups: control (PBS), LPS (LPS), and L+P (LPS plus …

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Comparison Of Venous Repair Results Using Either Arterial Or Vein Grafts In A Crush-Avulsion Injury Model, Selami̇ Serhat Şi̇rvan, Işil Akgün Demi̇r, Fati̇h Irmak, Dağhan Dağdelen, Kamuran Zeynep Sevi̇m, Ayşe Ayşi̇m Özağari, Ayşi̇n Karasoy Yeşi̇lada Jan 2019

Comparison Of Venous Repair Results Using Either Arterial Or Vein Grafts In A Crush-Avulsion Injury Model, Selami̇ Serhat Şi̇rvan, Işil Akgün Demi̇r, Fati̇h Irmak, Dağhan Dağdelen, Kamuran Zeynep Sevi̇m, Ayşe Ayşi̇m Özağari, Ayşi̇n Karasoy Yeşi̇lada

Turkish Journal of Medical Sciences

Background/aim: Venous insufficiency after replantation or revascularization is one of the most common causes of limb loss in either the short or the long term. The aim of this study was to evaluate the results of a new technique to overcome venous insufficiency.Materials and Methods: A crush-avulsion type of injury was formed in the femoral veins of rats of 3 separate groups. In the control group, primary repair was applied to the damaged veins and the remaining 2 groups were repaired with either an arterial graft or a vein graft. The success rates of anastomosis were then compared.Results: In the …

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Characterization And Haplotype Study Of 6 Novel Str Markers Related To The Kcnq1 Gene In Heterogeneous Cardiovascular Disorders In The Iranian Population, Azam Amirian, Zahra Zafari, Zohre Sharifi, Alireza Kordafshari, Morteza Karimipoor, Sirous Zeinali Jan 2019

Characterization And Haplotype Study Of 6 Novel Str Markers Related To The Kcnq1 Gene In Heterogeneous Cardiovascular Disorders In The Iranian Population, Azam Amirian, Zahra Zafari, Zohre Sharifi, Alireza Kordafshari, Morteza Karimipoor, Sirous Zeinali

Turkish Journal of Medical Sciences

No abstract provided.

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Urinary Phytate Concentration And Risk Of Fracture Determined By The Frax Index In A Group Of Postmenopausal Women, Angel Arturo Lopez Gonzalez, Felix Grases, Bartolome Mari, Matias Tomas-Salva, Adrian Rodriguez Jan 2019

Urinary Phytate Concentration And Risk Of Fracture Determined By The Frax Index In A Group Of Postmenopausal Women, Angel Arturo Lopez Gonzalez, Felix Grases, Bartolome Mari, Matias Tomas-Salva, Adrian Rodriguez

Turkish Journal of Medical Sciences

Background/aim: This study was designed to evaluate the relationship between urinary phytate concentration and risk of fracture at 10 years, determined by using the FRAX model, in women who had undergone menopause within 5 years of the time of enrollment. Materials and methods: Of the 212 postmenopausal women evaluated, 69 were excluded because they had urinary phytate concentrations between 0.51 and 0.99 mg/L. Of the remaining 143 women, 91 had low (≤0.50 mg/L) and 52 had high (≥1.0 mg/L) urinary phytate concentrations. The 10-year risk of fracture was calculated by using the FRAX model.Results: The risks of major osteoporotic fracture …

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Reference Ranges For Serum Immunoglobulin (Igg, Iga, And Igm) And Igg Subclass Levels In Healthy Children, Rumeysa Olcay Bayram, Hülya Özdemi̇r, Ayça Emsen, Hati̇ce Türk Daği, Hasi̇be Artaç Jan 2019

Reference Ranges For Serum Immunoglobulin (Igg, Iga, And Igm) And Igg Subclass Levels In Healthy Children, Rumeysa Olcay Bayram, Hülya Özdemi̇r, Ayça Emsen, Hati̇ce Türk Daği, Hasi̇be Artaç

Turkish Journal of Medical Sciences

Background/aim: The serum immunoglobulin levels are used routinely in clinical practice because they provide key information on the humoral immune status. This study aimed to determine the age-related reference values of serum immunoglobulin levels in healthy children.Materials and methods: A total of 330 healthy children, aged between 0 and 18 years, were included in this study. The serum immunoglobulin levels were measured using a nephelometric method in a total of 11 groups, each group consisting of 30 individuals, and IgG subclasses in 6 groups of children aged more than 2 years. Results: The serum IgG levels were high during the …

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Long-Term Monitoring Of Graves' Disease In Children And Adolescents: A Single-Center Experience, Selma Tunç, Özge Köprülü, Hati̇ce Ortaç, Özlem Nalbantoğlu, Ceyhun Di̇zdarer, Korcan Demi̇r, Behzat Özkan Jan 2019

Long-Term Monitoring Of Graves' Disease In Children And Adolescents: A Single-Center Experience, Selma Tunç, Özge Köprülü, Hati̇ce Ortaç, Özlem Nalbantoğlu, Ceyhun Di̇zdarer, Korcan Demi̇r, Behzat Özkan

Turkish Journal of Medical Sciences

Background/aim: Graves' disease (GD) is more severe, requires a more complex treatment, and has a lower probability of achieving remission in children than in adults. There is no consensus on the appropriate duration of antithyroid drug (ATD) treatment. Surgical or radioactive iodine (RAI) treatments are not definitive and generally result in permanent hypothyroidism.This study's goal was examining the effectiveness of ATD treatment in children and adolescents withGD and determining the risk factors of remission and relapse.Materials and methods: This retrospective study included 45 patients (36 females and 9 males, median age 12.5 years) aged 4-18 who were diagnosed with GD …

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High Neutrophil-To-Lymphocyte Ratio Predicts Acute Allograft Rejection In Kidney Transplantation: A Retrospective Study, Gi̇ray Ergi̇n, Serpi̇l Müge Değer, Burak Köprü, Ülver Deri̇ci̇, Seli̇m Turgay Arinsoy Jan 2019

High Neutrophil-To-Lymphocyte Ratio Predicts Acute Allograft Rejection In Kidney Transplantation: A Retrospective Study, Gi̇ray Ergi̇n, Serpi̇l Müge Değer, Burak Köprü, Ülver Deri̇ci̇, Seli̇m Turgay Arinsoy

Turkish Journal of Medical Sciences

Background/aim: Our research focused on the identification of easily available and sensitive markers for early prediction of acute kidney allograft rejection (AR). We aimed to investigate the association between neutrophil-to-lymphocyte ratio (NLR) and AR in kidney transplant patients. Materials and methods: The medical records of 51 kidney transplant patients [12 female/39 male; median age of 32 (IQR: 24-44) years] were evaluated retrospectively. We considered a cut-off value of >2.5 as high NLR. Results: A total of 22 biopsy-proven AR patients and 29 controls were evaluated. The AR group had a higher NLR compared to the controls (P < 0.001). NLR levels over 2.5 [95% CI: 54.88 (9.96-302.3), P < 0.001] were significantly associated with AR in univariate analysis. The NLR levels were the only significant factor associated with AR in multivariate models, in model 1 (adjusted by age and sex) [95% CI: 114 (11.1-1175), P < 0.001], and in model 2 (adjusted by steroid dosage, uric acid, and NLR) [95% CI: 4.60 (1.59-29.3), P = 0.004]. Conclusion: Our data showed that higher NLR values (>2.5) are associated …

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Seroprevalence Of Hantavirus And Borreliaburgdorferi In Düzce (Turkey) Forest Villages And The Relationship With Sociodemographic Features, Ni̇da Akar, Emel Çalişkan, Ci̇hadi̇ye Eli̇f Öztürk, Handan Ankarali, Özge Kilinçel, Şükrü Öksüz, İdri̇s Şahi̇n Jan 2019

Seroprevalence Of Hantavirus And Borreliaburgdorferi In Düzce (Turkey) Forest Villages And The Relationship With Sociodemographic Features, Ni̇da Akar, Emel Çalişkan, Ci̇hadi̇ye Eli̇f Öztürk, Handan Ankarali, Özge Kilinçel, Şükrü Öksüz, İdri̇s Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Hantavirus and Borrelia burgdorferi are two zoonotic agents that pose a great risk especially for people living in forest areas. This study aimed to investigate the seroprevalence of hantavirus and B. burgdorferi in forest villages of Düzce and its relationship with sociodemographic features.Materials and methods: The presence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against hantavirus and B. burgdorferi in serum samples was investigated via enzyme-linked immunosorbent assay (ELISA). Hantavirus IgG and B. burgdorferiIgM and IgG positivity was then validated by western blot (WB) method. Results: During the analyses,193 serum samples were tested. Eleven (6%) cases of …

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Influence Of Lrp5 (Rs556442) Polymorphism On Insulin Resistance In Healthy Iranian Children And Adolescents, Nima Montazeri Najafabady, Mohammad Hossein Dabbaghmanesh, Rajeeh Mohamadian-Amiri, Marzieh Bakhshayeshkaram, Gholamhossein Ranjbar Omrani Jan 2019

Influence Of Lrp5 (Rs556442) Polymorphism On Insulin Resistance In Healthy Iranian Children And Adolescents, Nima Montazeri Najafabady, Mohammad Hossein Dabbaghmanesh, Rajeeh Mohamadian-Amiri, Marzieh Bakhshayeshkaram, Gholamhossein Ranjbar Omrani

Turkish Journal of Medical Sciences

Background/aim: Genetic aspects play a role in insulin resistance in children. In this study, for the first time, the association of LRP5 (rs556442) polymorphism and insulin resistance in Iranian children and adolescents was investigated.Materials and methods: The study population comprises children and adolescents aged 9-18 years. Anthropometric and biochemical parameters were assessed. Insulin resistance/sensitivity was determined by the quantitative insulin sensitivity check index (QUICKI), homeostasis model assessment-insulin resistance (HOMA-IR), insulin-to-glucose ratio, McAuley index, revised McAuley index, fasting insulin resistance index (FIRI), and Bennett's index. LRP5 (rs566442) single nucleotide polymorphism (SNP) was identified using restriction fragment length polymorphism (RFLP). Linear regression …

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Prevalence Of Atopy And Allergic Rhinitis In Patients With Adult Non-Cystic Fibrosis Bronchiectasis, Eli̇f Yelda Ni̇ksarlioğlu, Saci̇de Rana Işik, Mehmet Ati̇lla Uysal, Derya Ünal, Güngör Çamsari Jan 2019

Prevalence Of Atopy And Allergic Rhinitis In Patients With Adult Non-Cystic Fibrosis Bronchiectasis, Eli̇f Yelda Ni̇ksarlioğlu, Saci̇de Rana Işik, Mehmet Ati̇lla Uysal, Derya Ünal, Güngör Çamsari

Turkish Journal of Medical Sciences

Background/aim: Non-cystic fibrosis bronchiectasis (non-CF BR) is common in developing countries.Limited data are available regarding the impact of atopy, and no data are available regarding allergic rhinitis in patients with adult bronchiectasis.The aim of this study was to evaluate the prevalence of atopy and allergic rhinitis in the clinical conditions of patients with BR.Materials and methods: The study enrolled 101 patients who were diagnosed with non-CF BR using high-resolution computed chest tomography. Allergic rhinitis (AR) was defined by skin prick test (SPT) positivity and the presence of any nasal symptoms (watery runny nose, nasal obstruction, nasal itching, and sneezing). Results: …

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Reliability, Validity, And Cross-Cultural Adaptation Study Of The Turkish Version Of The Patient-Rated Wrist/Hand Evaluation Questionnaire, Deni̇z Öke Topcu, Sevği̇ İkbali̇ Afşar Jan 2019

Reliability, Validity, And Cross-Cultural Adaptation Study Of The Turkish Version Of The Patient-Rated Wrist/Hand Evaluation Questionnaire, Deni̇z Öke Topcu, Sevği̇ İkbali̇ Afşar

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to cross-culturally adapt the Turkish version of the Patient-Rated Wrist/Hand Evaluation (T-PRWHE) questionnaire for use in the Turkish patient population. Moreover, we aimed to evaluate the reliability and validity of the T-PRWHE questionnaire. Materials and methods: A total of 166 patients with hand and wrist problems were included in the study. They completed the T-PRWHE, the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, and the 36-Item Short-Form Health Survey (SF-36) at baseline and at the 3rd month of the study. Reliability was evaluated by analyzing internal consistency (Cronbach alpha coefficient) and …

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Evaluation Of Sarcopenia, Sarcopenic Obesity, And Phase Angle In Geriatric Gastrointestinal Cancer Patients: Before And After Chemotherapy, Derya Hopanci Biçakli, Rüksan Çehreli̇, Ahmet Özveren, Reci̇ Meseri̇, Rüçhan Uslu, Mehmet Uyar, Bülent Karabulut, Selahatti̇n Fehmi̇ Akçi̇çek Jan 2019

Evaluation Of Sarcopenia, Sarcopenic Obesity, And Phase Angle In Geriatric Gastrointestinal Cancer Patients: Before And After Chemotherapy, Derya Hopanci Biçakli, Rüksan Çehreli̇, Ahmet Özveren, Reci̇ Meseri̇, Rüçhan Uslu, Mehmet Uyar, Bülent Karabulut, Selahatti̇n Fehmi̇ Akçi̇çek

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to determine sarcopenia, sarcopenic obesity and phase angle (PA) and the influence of chemotherapy (CT) on anthropometric measurements and and the PA in in geriatric patients with gastrointestinal (GI) cancer. Material and methods: The anthropometric measurements, calf circumference (CC), upper midarm circumference (UMAC), and hand grip strength (HGS), have been measured to understand muscle function of 153 patients (mean age of 70.5 ± 5.6 years, 28.8% female, 71.2% male). Sarcopenia and PA measurements have been evaluated by bioelectrical impedance analyses. The same evaluations were checked again after 1 cycle of CT (min: 4, …

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Percutaneous Navigable Intradiscal Decompression In Treatment Of Lumbar Disc Herniation: A Single-Center Experience, Ayşegül Ceylan, Ibrahim Asik Jan 2019

Percutaneous Navigable Intradiscal Decompression In Treatment Of Lumbar Disc Herniation: A Single-Center Experience, Ayşegül Ceylan, Ibrahim Asik

Turkish Journal of Medical Sciences

Background/aim: Minimally invasive procedures have been increasingly used for the treatment of herniated discs. Nonsurgical interventions minimize the secondary damage to other tissues and shorten the length of hospital stay by avoiding general anesthesia. Possible complications are thermal injuries, root injury, discitis, endplate damage, dural injury, meningitis, infection, increase in pain, and muscle spasm. We aimed to evaluate the efficacy of percutaneous decompression therapy by using intradiscal navigable electrodes on pain and functional movement index in patients with herniated nucleus pulposus (HNP).Materials and methods: A total of 209 patients with protrusive lumbar disc herniation underwent percutaneous ablation decompression treatment using …

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Glutamate Transporter Slc1a1 Is Associated With Clear Cell Renal Cell Carcinoma, Sercan Ergün, Sezgi̇n Güneş, Recep Büyükalpelli̇, Oğuz Aydin Jan 2019

Glutamate Transporter Slc1a1 Is Associated With Clear Cell Renal Cell Carcinoma, Sercan Ergün, Sezgi̇n Güneş, Recep Büyükalpelli̇, Oğuz Aydin

Turkish Journal of Medical Sciences

Background/aim: This study aimed to comparatively analyze the expression levels of the SLC1A1 gene in renal specimens from tumors and adjacent healthy kidney tissues of patients with clear cell renal cell carcinoma (ccRCC).Material and methods: Nineteen patients diagnosed with ccRCC were included in the study. The expression levels of the SLC1A1 and GAPDH genes were measured in tumor and formalin-fixed paraffin-embedded (FFPE) tissue specimens from the adjacent healthy kidney of each subject. Via the GEPIA database, the distribution of SLC1A1 gene expressions in ccRCC and healthy kidney tissues was obtained. The relative expression of SLC1A1 was evaluated for the association …

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Mortality Predictors Of Patients Suffering Of Acute Pancreatitis And Development Of Intraabdominal Hypertension, Maja Stojanovic, Petar Svorcan, Aleksandar Karamarkovic, Nebojsa Ladjevic, Radmilo Jankovic, Predrag Stevanovic Jan 2019

Mortality Predictors Of Patients Suffering Of Acute Pancreatitis And Development Of Intraabdominal Hypertension, Maja Stojanovic, Petar Svorcan, Aleksandar Karamarkovic, Nebojsa Ladjevic, Radmilo Jankovic, Predrag Stevanovic

Turkish Journal of Medical Sciences

Background/aim: Intraabdominal hypertension (IAH) occurs frequently in patients with acute pancreatitis and adds to their morbidity and mortality. The main aim of the study was to identify the determination of the predictive factors connected to IAH that influence the evolution of acute pancreatitis. Materials and methods: The prospective cohort study was conducted on 100 patients who had acute pancreatitis. According to obtained intraabdominal pressure (IAP) values, the patients were divided into two groups: one group (n = 40) with normal IAP values and the other (IAH group, n = 60) with increased IAP values. Deceased patients were specially analyzed within …

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Mild To Moderate Proteinuria Is A Heralding Sign For Acute Kidney Injury And Mortality For Intensive Care Unit Patients, Haci Hasan Yeter, Tolga Yildirim, Nesri̇n Damla Eyüpoğlu, Tural Pasayev, Abdullah Tarik Aslan, Sila Çeti̇k, Ömer Faruk Akçay, Arzu Topeli̇ İski̇t, Mustafa Arici Jan 2019

Mild To Moderate Proteinuria Is A Heralding Sign For Acute Kidney Injury And Mortality For Intensive Care Unit Patients, Haci Hasan Yeter, Tolga Yildirim, Nesri̇n Damla Eyüpoğlu, Tural Pasayev, Abdullah Tarik Aslan, Sila Çeti̇k, Ömer Faruk Akçay, Arzu Topeli̇ İski̇t, Mustafa Arici

Turkish Journal of Medical Sciences

Background/aim: Lack of early predictors of acute kidney injury is currently delaying timely diagnosis.This study was done to evaluate the relationship between mild to moderate proteinuria and incidence of acute kidney injury (AKI) and 28-day mortality in intensive care unit (ICU) patients. Material and methods: This observational, retrospective study was conducted in the internal medicine ICU. A total of 796 patients were screened and 525 patients were used for this analysis. Proteinuria was measured by urine dipstick test. AKI was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. Results: Patients with dipstick urine protein positivity on admission …

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Efficacy Of Chemical Shift Mri For Differentiating Diffuse Red Bone Marrow Reconversion And Hematological Malignancies, Burcu Akman, Hati̇ce Ayça Ata Korkmaz, Ahmet Sari Jan 2019

Efficacy Of Chemical Shift Mri For Differentiating Diffuse Red Bone Marrow Reconversion And Hematological Malignancies, Burcu Akman, Hati̇ce Ayça Ata Korkmaz, Ahmet Sari

Turkish Journal of Medical Sciences

Background/aim: The main purpose of our study was to determine the efficacy of chemical shift imaging (CSI) for differentiating diffuse red bone marrow reconversion (RBMR) and hematological malignancies. We also aimed to calculate the cut-off value for these entities with similar imaging features in routine magnetic resonance (MR) sequences.Materials and methods: A total of 54 patients were included: 17 patients (31.4%) with hematological malignancies (group 1), 16 patients (29.6%) with RBMR (group 2), and 21 patients (38.0%) with no clinical and hematological malignancies (control group). Patients with no pathological data or completed two-year follow-up and children were excluded from the …

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The Impact Of Jak/Stat Inhibitor Ruxolitinib On The Genesis Of Lymphoproliferative Diseases, Can Türk, Müfi̇de Okay, Seyhan Türk, Eli̇f Sena Temi̇rci̇, Osama Jawad, Sali̇h Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu Jan 2019

The Impact Of Jak/Stat Inhibitor Ruxolitinib On The Genesis Of Lymphoproliferative Diseases, Can Türk, Müfi̇de Okay, Seyhan Türk, Eli̇f Sena Temi̇rci̇, Osama Jawad, Sali̇h Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu

Turkish Journal of Medical Sciences

Background/aim: Ruxolitinib, a JAK/STAT signaling pathway inhibitor targeted drug, has been approved for the controlling of disease symptoms and splenomegaly in patients with myeloproliferative neoplastic diseases. Recently, it has been proposed that ruxolitinib-induced JAK/STAT pathway inhibition in myelofibrosis is associated with an elevated frequency of aggressive B-cell lymphomas. However, the biological basis and significance of this pharmacobiological adverse event is unknown. The aim of this bioinformatics study is to detect any possible confounding effects of ruxolitinib on the genesis of lymphoproliferative disorders. Materials and methods: The gene expression data were retrieved from the E-MTAB-783 Cancer Genome Project database. Gene expression …

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