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Copper-Catalyzed Regioselective Boracarboxylation Of Vinyl Arenes: Catalytic Efficiency And Synthetic Utility, Trina M. Perrone

Graduate Theses, Dissertations, and Problem Reports (ETD)

Hetero(element) carboxylation is an appealing transformation that involves the installation of CO2 and another hetero(element) in one step. This transition metal-catalyzed one-pot synthesis provides a route to achieve highly functionalized carboxylic acid products with an abundant and cheap C1 feedstock. This difunctionalization also avoids the use of reactive metal hydride species, which is a prominent limitation of hydrocarboxylation chemistry. A copper-catalyzed regioselective boracarboxylation of vinyl arenes has been developed to access pharmaceutically relevant β-boryl-α-aryl propionic acid products. One drawback of this reaction is the necessity for high catalyst loading to achieve catalytic turnover. To circumvent this issue, the reduction of …

Evaluating Post-Fire Plantation Restoration In A Mixed Conifer Forest In The Sierra Nevada, Iris C. Allen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Forests in the western United States have experienced a shift from historical disturbance regimes in the past century. Many of these changes were induced by European settlers logging the forests and suppressing fires. In the past, the dry mixed conifer forests of California’s Sierra Nevada mountains experience frequent, low to mixed severity fires. This fire regime helped maintain a heterogeneous landscape comprised of groups of trees and openings. However, due to fire suppression and high grading logging, forest structure has changed; there are less openings and more small, fire-intolerant trees that can carry a fire into the forests crown. The …

A Video Decision Aid To Influence Advance Care Planning, Angela Petry

Graduate Theses, Dissertations, and Problem Reports (ETD)

The best mechanism to achieve successful advance care planning has yet to be identified. A randomized, controlled, experimental study was performed with a sample of 54 men and women who met inclusion criteria and were randomized into the intervention versus the control group in an outpatient clinical setting in rural West Virginia (WV) from December 2018 to March 2019. Participant mean age was 72.4 years. For those who chose to participate (n=42), the intervention group received the usual standard of care, which was a face to face advance care planning (ACP) discussion with the new intervention of a video decision …

An Investigation Of The Relation Between Mindfulness And Self-Esteem Stability, Cameron Grant Ford

Graduate Theses, Dissertations, and Problem Reports (ETD)

Self-esteem stability is the magnitude of the short-term fluctuations in one’s immediate feelings of self-worth (Kernis, 2005). Stable self-esteem is associated with several psychological benefits, such as lower depression (Kernis et al., 1998). However, it is unknown what factors lead to self-esteem stability. Because mindfulness promotes a nonjudgmental orientation whereby thoughts, feelings, and reactions are viewed as transient events that do not necessarily represent objective reality, mindfulness might be associated with more stable self-esteem. Thus, the present research examined the relation between mindfulness and self-esteem stability. Undergraduates (N = 190) were randomly assigned to one of three conditions: mindfulness …

Untangling The Reciprocal Relation Of The Behavioral And Physiological Immune Systems, Baris Sevi

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the past decade, there has been an exponential increase in the study of the Behavioral Immune System (BIS), a suite of psychological processes that serves an infectious disease avoidance function. The BIS is proposed to be inherently intertwined with the physiological immune system. However, very few studies have actually demonstrated this fundamental, theoretical assumption. The purpose of this thesis was to test the possible relation between the physiological and behavioral immune systems in two studies. In Study 1 (N = 388), the relation between implied activation of the physiological immune system and BIS sensitivity was examined. Participants who reported …

Behavioral And Anti-Inflammatory Effects Of Magl Inhibition In A Mouse Model Of Inflammatory Arthritis, Floyd Franklin Steele Iii

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cannabinoids have analgesic and anti-inflammatory properties. For example, in preclinical models of acute inflammatory pain, cannabinoid receptor subtype 2 (i.e., CB_2, Table 1) agonists decrease paw inflammation and resulting pain. Yet, the anti-inflammatory properties of cannabinoid receptor manipulation in chronic inflammatory pain states are unknown. Monoacylglycerol lipase (MAGL) is the primary catabolic enzyme of the endocannabinoid (i.e., endogenous cannabinoid ligand) 2-arachidonoyl glycerol (i.e., 2-AG). Compounds that inhibit MAGL indirectly increase tissue levels of 2-AG by preventing its catabolism. MAGL inhibitors demonstrate efficacy in acute models of inflammatory/rheumatic disease. Thus, in this study, the MAGL inhibitor JZL184 was tested …

Choose Your Own Lecture: Students’ Motivational Resources As A Consequence Of Autonomy-Supportive Instruction, James P. Baker

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this dissertation was to extend the self-determination theory literature by investigating the utility of the choose your own lecture method of instruction. This method of instruction allows students to control the direction of a lesson. In line with the theoretical propositions of SDT, the researcher hypothesized that this style of teaching would support students’ inner motivational resources (i.e., autonomy-need satisfaction and intrinsic motivation) and in turn, foster students’ interest in the topic of the lesson, free-choice persistence, cognitive learning, affect for the course, and expressive dissent. A 50-minute live-lecture experiment on environmental communication (climate change, risk communication, …

Genetic And Pharmacologic Studies Towards Prevention Of Opioid Use Disorder, Shane W. Kaski

Graduate Theses, Dissertations, and Problem Reports (ETD)

Endogenous opioids mediate both analgesic and affective responses to stress. While the mu opioid receptor (MOR) produces the reinforcing euphoric effects responsible for the high abuse potential of traditional opioid analgesics, the kappa opioid receptor (KOR) is hypothesized to mediate the dysphoric component of stress. With increasing rates of opioid addiction, extensive research efforts are focused on better understanding each of these systems and how they interact, with the goal of developing less addictive pain management strategies and better approaches to addiction treatment. With this in mind, we conducted both clinical and pre-clinical studies aimed at developing better treatment strategies …

Environmental Regulation Of The Heart: The Role Of Non-Coding Rna And Epigenetics In Influencing Mitochondrial And Cellular Health, Quincy Alexander Hathaway

Graduate Theses, Dissertations, and Problem Reports (ETD)

The mitochondrion, a small but ubiquitously distributed organelle in the cell, continues to be the focus of many disease pathogeneses, tissue and organ dysfunctions, and other morbidities that occur throughout the body. The purpose of this work was to understand how cardiac mitochondrion are altered in disease and pathological states, specifically in their adaptation to environmentally stimulated regulatory networks, such as epigenetic modifications and promotion/inhibition of non-coding RNAs. Acute stress to mitochondrial regulation (inhalation toxicology) as well as chronic (type 2 diabetes mellitus) was examined. Using a FVB transgenic microRNA-378a mouse knockout model, the cardiovascular impact derived from altering the …

About A Revolution: Toward Integrated Treatment In Drug And Mental Health Courts, Sara Gordon

All Faculty Publications

and mental health courts, which proponents claim created a revolution in criminal justice. Defendants whose underlying crime is the result of a substance use disorder or a mental health disorder can choose to be diverted into a specialty court, where they receive treatment instead of punishment. Many of these individuals, however, do not just suffer from a substance use disorder or a mental health disorder; instead, many have a “cooccurring disorder.” Approximately 8.9 million American adults have co-occurring mental health and substance use disorders, and almost half of individuals who meet diagnostic criteria for one disorder will also meet criteria …

Family Separation And The Impact Of Digital Technology On The Mental Health Of Refugee Families In The United States: Qualitative Study, Sayyed Fawad Ali Shah, Julia Meredith Hess, Jessica R. Goodkind

Research, Publications & Creative Work

Background: Conflicts around the world have resulted in a record high number of refugees. Family separation is a critical factor that impacts refugee mental health. Thus, it is important to explore refugees’ ability to maintain contact with family members across the globe and the ways in which they attempt to do so. It is increasingly common for refugees to use information and communication technologies (ICTs), which include mobile phones, the internet, and social media sites, such as Facebook, WhatsApp, Skype, and Viber, for these purposes.

Objective: The aim of this study was to explore refugees’ perceptions of the …

Clinical Experts Statement: The Definition, Prescription, And Application Of Cupping Therapy, S. Andrew Cage, Diana M. Gallegos, Brian Coulombe, Brandon J. Warner

Clinical Practice in Athletic Training

No abstract provided.

Point-Of-Care Assessment At A Free, Out-Of-Hours Orthopedic Clinic, Whitney M. Graves, Zachary K. Winkelmann, Kenneth E. Games

Clinical Practice in Athletic Training

Access to healthcare is a challenge for many Americans living in rural communities. Hospital systems have created programs and developed models to improve access to care. However, documentation of the role of these clinics serving different populations and various types of communities is quite scarce. The purpose of this article is to describe the patient satisfaction and procedures assessed at the point-of-care during a 14-week, out-of-hours free orthopedic clinic in the Southeastern United States. One hundred and twenty-nine patients attended the orthopedic clinic and completed a patient satisfaction survey following their patient encounter. At the end of the 14-week, 89% …

Graston Technique® As A Treatment For Patients With Chronic Plantar Heel Pain, Troy R. Garrett, Peter J. Neibert

Clinical Practice in Athletic Training

Use of Instrument-Assisted Soft Tissue Massage has increased in popularity, and the plantar fascia is a superficial tissue that may benefit from this treatment. The objective of this study was to determine the effectiveness of Graston Technique® (GT) for decreasing pain and increasing function in participants with chronic plantar heel pain over a six-week period. A single blind, pretest-posttest control/comparison group design, with a sample of 22 adults (5 males, 17 females) was utilized. Participants were assigned to three groups: GT/stretching, effleurage/stretching, and stretching only. After completion, effleurage/stretching and stretching only groups were later offered GT with posttest scores recorded. …

Treatment Of Scapular Dyskinesis With Reflexive Neuromuscular Stimulation: A Case Report, Alli Z. Powell, Russell T. Baker

Clinical Practice in Athletic Training

Scapular dyskinesis is an abnormal movement of the scapula due to poor motor control of the surrounding musculature and can lead to other glenohumeral pathologies. The pathology results in the lateral tilting of the scapula during many glenohumeral joint movements and weight-bearing activities of the upper extremity (i.e., plank). The typical conservative treatment protocol focuses on strengthening surrounding musculature and is often a lengthy protocol. A weakness of strengthening protocols is the failure to address the motor function of targeted muscles at the level of the central nervous system (CNS) to restore dynamic stability and motor control. Reactive Neuromuscular Stabilization …

The Mulligan Concept In The Treatment Of Anterior Knee Pain, Karla S. Judge, Alan Nasypany, Russell T. Baker, James May

Clinical Practice in Athletic Training

The purpose of the disablement model case study was to describe the case of a collegiate basketball player suffering from anterior knee pain (AKP). The patient had been experiencing AKP while participating in pre-season basketball related activities (playing, weight lifting, and conditioning) for approximately six weeks. As the intensity increased, the pain became intolerable. Previously, the patient had missed a significant amount of off-season workouts due to surgery for an upper extremity injury sustained during the competitive season. The patient reported tenderness at the inferior pole of the patella, and at the tibial tuberosity. There was no joint line tenderness, …

Mesenchymal Stem Cells: Sources, Clinical Applications And Outcomes For Common Musculoskeletal Conditions, Steven Boyton, Lindsey Clemensen

Clinical Practice in Athletic Training

Background: The clinical use of Mesenchymal Stems Cells (MSC) in musculoskeletal medicine has become increasingly recognized in the medical field as a promising treatment modality. MSCs have been defined as spindle shaped cells that are capable of rapid proliferation and self-renewal contained within several tissues including bone marrow, synovial and adipose tissue, blood and periosteum. MSCs are currently being used in clinical trials for musculoskeletal purposes including the enhancement of tissue regeneration, bone and cartilage defects and tissue repair. Currently a variety of stem cell products, methods and applications are being used which can provide many misconceptions for the most …

Pelvic And Sacral Size Dimorphism And Allometry In Two Predatory Carnivores With Different Life Histories And Locomotory Adaptations, Alexander Csanady, Peter Krisovsky, Ladislav Hloska

Turkish Journal of Zoology

Sexual size dimorphism (SSD) of the wolf and the lynx was evaluated for 15 pelvic and sacral variables in 48 specimens from the Western Carpathians. Our data confirmed small male-biased SSD in the pelvic and sacral bones for both species. We suggest that this can be explained by the need for a compromise between requirements for locomotion and giving birth. We also confirmed that significant differences exist between the species in the size of the pelvic and sacral bones. We discuss our findings in light of the species? different life histories.

All Aspects Of The Toxic Effects Of Lipopolysaccharide On Rat Liver And The Protective Effect Of Vitamin E And Sodium Selenite, Di̇lek Pandir, Sedat Per, Züleyha Doğanyi̇ği̇t, Fati̇h Oğuz Bekdemi̇r, Gülşi̇fe Gök, Ali̇ Demi̇rbağ

Turkish Journal of Zoology

This work was planned to research the effects of lipopolysaccharide (LPS) and/or vitamin E (VE) and sodium selenite (SS), which have antioxidant properties, administered to the liver tissue of male rats. For this purpose, histopathology, immunohistochemistry, antioxidant capacity, terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling assay, liver function, and DNA structure tests were performed. The lipid profile was also evaluated in this study. Rats that were administered LPS were treated with VE and/or SS. The liver function tests and lipid profile parameters showed statistically significant changes and histological alterations in the LPS treated groups. The number of cells entering apoptosis …

Heavy Metal Accumulation As A Threat To The Endangered Egyptian Vulture(Neophron Percnopterus L.) In Turkey, Eli̇f Yamaç, Menekşe Özden, Sunay Balaban, Semra Malkoç

Turkish Journal of Zoology

Due to anthropogenic activity, most vulture species are threatened. Neophron percnopterus, the Egyptian vulture, is a vulture species with a declining population. One of the most important factors threatening the species is exposure to chemicals. The second largest population of this bird species is found in Turkey. Accumulation of heavy metals for this species has not been investigated. The aim of this study was to detect and measure As, Cd, Cr, Cu, Hg, Ni, Pb, and Zn values in the feathers of Neophron percnopterus. Calamis and vane, which are different part of the feathers, were analyzed separately with ICP-OES. According …

Neuroprotective Role Of Delta Opioid Receptors In Hypoxic Preconditioning, Şevi̇n Güney, Si̇bel Di̇ncer, Güleser Göktaş, Gülnur Take Kaplanoğlu

Turkish Journal of Medical Sciences

Background/aim: The purpose of the present study was to explore the neuroprotective role of delta opioid receptors (DOR) in the rat cortex in hypoxic preconditioning. Materials and methods: Rats were randomly divided into 8 groups: control (C), sham (S), hypoxic preconditioning (PC), severe hypoxia (SH), PC + SH, PC + SH + Saline (PS), PC + SH + DPDPE (DPDPE, selective DOR agonist), PC + SH + NT (NT, Naltrindole, selective DOR antagonist). Drugs were administered intracerebroventrically. Twenty four h after the end of 3 consecutive days of PC (10% O2, 2 h/day), the rats were subjected to severe hypoxia …

Seasonal, Sex Variations In Vitamin D Levels And Their Association With Pulmonary Function In Children With Asthma, Şebnem Özdoğan

Turkish Journal of Medical Sciences

Background/aim: We aimed to examine the seasonal and sex variations in vitamin D levels in children with asthma and their associations with lung function. Materials and methods: We conducted a cohort study involving children aged 7?17 years old with asthma. Vitamin D levels were obtained and pulmonary function tests (PFTs) were performed in winter months (December, January, and February) and at the end of summer (August, September, and October). Seasonal and sex variations in vitamin D levels and lung function were examined. Results: A total of 56 children (26 males, mean age: 11.93 ± 1.8) were enrolled. The mean vitamin …

A Novel Marker Relationship Between Carotid Intima-Media Thickness And Disease Activity Score-28 In Patients With Rheumatoid Arthritis: Human Endothelial Cell-Specific Molecule-1, Göksel Tuzcu, Ali̇ Uğur Uslu, Ayça Tuzcu, Rabi̇a Aydoğan Baykara, Ahmet Omma, Adem Küçük

Turkish Journal of Medical Sciences

Background/aim: Human endothelial cell-specific molecule-1 (endocan) is a marker of vascular endothelial dysfunction that may be used in the evaluation of inflammatory-associated atherosclerotic lesions. Endocan may be a marker for the evaluation of atherosclerosis and disease activity in rheumatoid arthritis (RA) patients.Materials and methods: We included 39 RA patients assessed according to the American College of Rheumatology/European League Against Rheumatology 2010 diagnostic criteria and recruited 30 age- and sex-matching healthy subjects for the control group.Results: Endocan values were 14.11 ± 3.27 for the RA patients and 12.10 ± 2.92 for the controls. The endocan values of the patients were significantly …

The Role Of Right Ventricular Volumes And Inferior Vena Cava Diameters In The Evaluation Of Volume Status Before Colonoscopy, Şule Arican, Ramazan Dertli̇, Çağdaş Dağli, Gülçi̇n Hacibeyoğlu, Mustafa Koyuncu, Ahmet Topal, Sema Tuncer Uzun, Mehmet Asil

Turkish Journal of Medical Sciences

Background/aim: Ultrasonographic measurements of inferior vena cava (IVC) diameters and right ventricle (RV) volumes are important tools for the evaluation of intravascular volume. The current study investigates the association of IVC diameters and RV volumes before colonoscopy in prediction of postanesthesia hypotension.Materials and methods: Seventy patients scheduled for colonoscopy were included in the study. Preoperatively, expirium (dIVC max) and inspirium (dIVC min) IVC diameters were measured using M-mode ultrasonography and the collapsibility index (IVC-CI) was calculated. Ventricular volumes and areas were also measured using transthoracic echocardiography. Postanesthesia hypotension was defined as mean arterial blood pressure of 30% in the mean …

Initial Regional Evaluation Of The Cystic Fibrosis Newborn Screening Program: Data From The Mediterranean Coast Of Turkey, Abdurrahman Erdem Başaran, Ayşen Başaran, Di̇lara Fatma Kocacik, Özgül Alper, Deni̇z Acican, Ayşen Bi̇ngöl

Turkish Journal of Medical Sciences

Background/ aim: Since January 2015, the Cystic Fibrosis Newborn Screening (CFNS) program has been implemented in Turkey. We aimed to evaluate the demographic, clinical, and laboratory data of cases referred from the CFNS program and to determine the most suitable cut-off value for immunoreactive trypsinogen (IRT)-1 and immunoreactive trypsinogen (IRT-2) that are used in the CFNS program in Turkey. Materials and methods: A total of 156 Turkish Caucasian subjects were determined as positive cases during 3 years, from January 2015 to January 2018, and were referred to the pediatric pulmonology clinics of Akdeniz University Hospital, Antalya, Turkey, for the national …

The Validity And Reliability Of The Turkish Version Of The Physical Activity Scale For Individuals With Physical Disabilities (Pasipd), Kardem Ulaş, Semra Topuz, Gönül Horasan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to assess the validity and reliability of Turkish translation of thePhysical Activity Scale for Individuals with Physical Disabilities (PASIPD) in a disabled Turkish population.Materials and methods: Following the translation protocol of the PASIPD, the Turkish version of the PASIPD, Short Form-36, and International Physical Activity Questionnaire were administered to 198 developmentally and physically disabled individuals.Results: The Turkish version of the PASIPD was found to be reliable. The domains of the Turkish version of the PASIPD were also found to be valid. Four factors were obtained from the questionnaire. The ICC was 1.0 since …

The Effect Of Parathyroidectomy On Bone Mineral Density In Primary Hyperparathyroidism, Mustafa Çalişkan, Selvi̇han Beysel, Muhammed Kizilgül, Mustafa Özbek, Erman Çakal

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the change in bone mineral density (BMD) before and 1 year after parathyroidectomy in patients with primary hyperparathyroidism (PHPT). Materials and methods: The clinical and biochemical parameters and DEXA screening of patients with symptomatic PHPT (n = 28) and asymptomatic PHPT (n = 63) were investigated before and 1 year after parathyroidectomy. Results: Patients with symptomatic PHPT had a higher prevalence of nephrolithiasis (18.2% vs. 4.6%, P = 0.032) when compared to the prevalence in patients with asymptomatic PHPT. The prevalence of osteoporosis in the lumbar spine (63.0% vs. 37.5%, P = 0.026) and …

Clinical Results Of Intradiscal Hydrogel Administration (Gelstix) In Lumbar Degenerative Disc Disease, Ayşegül Ceylan, İbrahi̇m Aşik, Güngör Enver Özgenci̇l, Burak Erken

Turkish Journal of Medical Sciences

Background/aim: Degenerative disc disease (DDD) is one of the main causes of lower back pain. In this study, we evaluate the efficacy of percutaneous intradiscal GelStix administration in patients with discogenic pain due to lumbar DDD who were unresponsive to conservative methods.Materials and methods: A total of 29 patients were included in the study, which took place between 2013 and 2017. Sedation was performed in the prone position in the operating room, and a C-arm was located so as to provide a lateral view of the surgical field. A 22-G, 3.5-inch needle was inserted into the center of the disc …

Pipeline Flex Embolization Device (Ped Flex) For The Treatment Of Intracranial Aneurysms: Periprocedural Outcomes And First-Year Angiographic Results, Şükrü Oğuz, Ömer Naci̇ Tabakci, Ender Uysal, Eser Bulut, Hasan Di̇nç

Turkish Journal of Medical Sciences

Background/aim: The Pipeline Flex Embolization Device (PED Flex) is a new updated version of the PED classic that incorporates a new delivery system to allow facilitation of stent deployment, resheathing, and removal of the capture coil. This study evaluated the PED Flex in terms of the technical aspects of the procedure and first-year follow-up results. Materials and methods: This retrospective study involved prospectively collected data from May 2015 to August 2017. The primary endpoint was technical aspects of the procedure, and the secondary endpoint was first-year follow-up results. Results: Forty-nine patients with 59 target intracranial aneurysms were enrolled. Patients' mean …

The Effect Of Pregabalin On Tourniquet-Induced Ischemia-Reperfusion Injury:A Prospective Randomized Study, Ömer Karaca, Hüseyi̇n Ulaş Pinar, Ahmet Fevzi̇ Özgür, Sevsen Kulaksizoğlu, Rafi̇ Doğan

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the efficacy of pregabalin on ischemia-reperfusion injuries.Materials and methods: Fifty-four patients were randomly assigned into 2 groups. A 150-mg tablet of pregabalin was given the night before and then 1 h before the operation for patients in Group P (pregabalin group, n = 27). A placebo was given to patients in Group C (control group, n = 27) at the same times. After combined spinal-epidural anesthesia was performed, venous blood samples were taken before tourniquet inflation (t1), just before tourniquet deflation (t2), and 20 min after tourniquet deflation (t3) for the …