Digital Commons Network^™

Electronic Health Records: Improved Healthcare Is In Our Hands, Veronika Danchine

The Synapse: Intercollegiate science magazine

No abstract provided.

Word Find Game

The Synapse: Intercollegiate science magazine

No abstract provided.

The Synapse 20

The Synapse: Intercollegiate science magazine

No abstract provided.

Ccr5: The Perfect Mutation?, Anna Harrison

The Synapse: Intercollegiate science magazine

No abstract provided.

Phones: The Hand We Don't Wash, How To Protect Yourself Against Common Diseases, Nathalie Weiss

The Synapse: Intercollegiate science magazine

No abstract provided.

Did You Hear That? An Exploration Of Auditory Hallucinations In Schizophrenia Disorder, Victoria Fisher

The Synapse: Intercollegiate science magazine

No abstract provided.

Catalog Denison University 2019-2020

Denison University Catalogs

No abstract provided.

Employment Research, Vol. 26, No. 1, January 2019

Employment Research Newsletter

No abstract provided.

Enhancing The Productivity, Competitiveness And Independence Of Productive Cooperatives In Egypt / تحسين الانتاجية والتنافسية والاستقلالية للتعاونيات الإنتاجية بمصر, Yomna Mohamed Gamil Esmat

Papers, Posters, and Presentations

This paper sheds light on the conceptual framework of productive cooperatives, identifies the distinctive characteristics of this type of enterprises and examines the economic and social relative importance of the sector. Based on the importance of the cooperatives sector at the international level, and because of the many local efforts in Egypt that are aimed at promoting cooperatives at large, this paper identifies areas which need to be attended to by suitable legesilative and policy support and also examines selected international experiences, in order to draw lessons learned that can positively reflect on the situation in Egypt.

A Detection And Data Acquisition System For Precision Beta Decay Spectroscopy, Aaron P. Jezghani

Theses and Dissertations--Physics and Astronomy

Free neutron and nuclear beta decay spectroscopy serves as a robust laboratory for investigations of the Standard Model of Particle Physics. Observables such as decay product angular correlations and energy spectra overconstrain the Standard Model and serve as a sensitive probe for Beyond the Standard Model physics. Improved measurement of these quantities is necessary to complement the TeV scale physics being conducted at the Large Hadron Collider. The UCNB, ⁴⁵Ca, and Nab experiments aim to improve upon existing measurements of free neutron decay angular correlations and set new limits in the search for exotic couplings in beta decay. To …

Flexible Liminality Among The Tibetan Diaspora: Tibetan Exiles Adjusting Cultural Practices In Dharamsala, India And The United States, Sneha Thapa

Theses and Dissertations--Anthropology

In this dissertation, I investigate the characteristics and quality of liminality among the Tibetan exile community in Dharamsala, India, and the United States. I argue that the quality of their liminality defines this exile community’s ability to maneuver and voice their influence to geo-political community of states that surround them, all while within their liminal condition. The Tibetan exile people live as stateless foreigners in India but have a better standard of living and better opportunities to acquire transnational resources than their surrounding host community. In the U.S., Tibetan diaspora people live as asylum-seekers and naturalized Tibetan-Americans but have established …

Finding The Singing Spruce: Craft Labor, Global Forests, And Musical Instrument Makers In Appalachia, Jasper Waugh-Quasebarth

Theses and Dissertations--Anthropology

Musical instrument makers in the state of West Virginia in the United States pursue “singing,” lively instruments that capture ideals of musical tone and “re-enchant” their work and lives through relationships with craft materials and the forest landscape. Suitable tonewoods that grow in the region, such as red spruce (Picea rubens), intersect with makers’ desires to craft instruments in the style of famed makers such as the C.F. Martin Company and the Gibson Company as well as provide instruments imbued with a sense of place. While the demand for and symbolic import of instruments made with local wood …

Consuming Appalachia: An Archaeology Of Company Coal Towns, Zada Komara

Theses and Dissertations--Anthropology

Material culture is an understudied aspect of social life in Appalachian Studies, the multi- disciplinary investigation of social life in the Appalachian region. Historically, material culture in the region has been largely studied for its semiotic properties, decoded as a tangible symbol of “a region apart,” lagging behind the rest of America in terms of moral, mental, economic, and social development. Critical material studies from archaeology and other disciplines paint a different picture, however, and construct a region as American as any other. This study utilizes discourse analysis of material rhetoric about Appalachia and archaeological and oral historical data from …

The Wages Of Precarious Work: An Ethnography Of Upstate South Carolina’S Reserve Army Of The Laboring, Henry Bundy

Theses and Dissertations--Anthropology

The proliferation of precarious work represents a sea change in the opportunity structure of the new economies of the American South. As the role of the State has shifted from guarantor of rights and services to anxious custodian of economic liberalization, Americans have been enjoined to shoulder ever-larger shares of the responsibilities and risks associated with wage labor. As a result, the working poor have been left to weather the vicissitudes of the unfettered market with the increasingly paltry social membership guaranteed through waged employment. Among the risks now frequently assumed by individuals, are the responsibilities of health.

In the …

Making Experts: An Ethnographic Study Of “Makers” In Fablabs In Japan, Vaughn M. Krebs

Theses and Dissertations--Anthropology

“Makers” around the world cohere in a digital and physical network of technology hobbyists. “Makers" are open-source hardware enthusiasts who use machines like 3D printers and laser cutters - manufacturing tools that have only recently become accessible to laypeople - to make things. “Makers" share a vision for a world where everyone would be able to make almost anything, supplanting top-down economic systems and channels of production. This ethnographic research examines a subset of the “maker” community: “makers” in “FabLabs” in Japan. These “FabLabs” are small workshops that house the machines that “makers” need and make them open to the …

Ecological Rationality: Fast-And-Frugal Heuristics For Managerial Decision Making Under Uncertainty, Shenghua Luan, Jochen Reb, Gerd Gigerenzer

Research Collection Lee Kong Chian School Of Business

Heuristics are often viewed as inferior to “rational” strategies that exhaustively search and process information. Introducing the theoretical perspective of ecological rationality, we challenge this view and argue that under conditions of uncertainty common to managerial decision making, managers can actually make better decisions using fast-and-frugal heuristics. Within the context of personnel selection, we show that a heuristic called Δ-inference can more accurately predict which of two job applicants would perform better in the future than logistic regression, a prototypical rational strategy. Using data from 236 applicants at an airline company, we demonstrate in Study 1 that despite searching less …

Situational Judgment Tests As Measures Of 21st Century Skills: Evidence Across Europe And Latin America, Christoph Herde, Filip Lievens, Emily G. Solberg, Harbaugh Jan L., Mark H. Strong, Gary J. Burkholder

Research Collection Lee Kong Chian School Of Business

Over the years, various governmental, employment, and academic organizations have identified a list of skills to successfully master the challenges of the 21st century. So far, an adequate assessment of these skills across countries has remained challenging. Limitations inherent in the use of self-reports (e.g., lack of self-insight, socially desirable responding, response style bias, reference group bias, etc.) have spurred on the search for methods that could complement or even substitute self-report inventories. Situational judgment tests (SJTs) have been proposed as one of the complements/alternatives to the traditional self-report inventories. SJTs are low-fidelity simulations that confront participants with multiple domain-relevant …

Akt Expression And Lactose Synthesis During Heat Exposure In Saanen Goat, Nungnuch Saipin

Chulalongkorn University Theses and Dissertations (Chula ETD)

In tropical countries, high ambient temperature (HTa) is a fundamental factor that cause a decline in the mammary gland function in dairy animals. Dairy animals fed under HTa decreased milk yield (MY) as well as milk compositions. The current study focuses on the effect of HTa to decrease milk synthesis from natural and in vitro HTa condition. The first experiment was performed to investigate the effect of HTa from the natural condition in early lactating Saanen goat, 2-4 weeks of postpartum (2 PP-4 PP). Five animals were investigated during the winter season as control ambient condition. Six animals as the …

Studies Of Beta-Cardiotoxin From King Cobra Venom On Rat Cardiac Functions: Effect On Isolated Single Cardiomyocyte, Tuchakorn Lertwanakarn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Beta-cardiotoxin (ß-CTX), a novel protein isolated from the King cobra (Ophiophagus hannah) venom has previously been proposed as a beta-blocker candidate. However, cellular mechanisms of ß-CTX on cardiomyocyte is unknown. This study aimed to evaluate the impact of ß-CTX on isolated rat cardiomyocyte function and the cardiac myofibrillar activity, and to explore involvement of ß-adrenergic receptor (ß-AR) signaling pathway. ß-CTX was isolated and purified using two-step chromatographic method and confirmed by N-terminal sequencer. The function of ß-CTX on cardiomyocyte was compared to propranolol in 3 conditions, basal state, with isoproterenol (ISO), and with forskolin (FSK). ß-CTX exhibited more potency than …

The Left Ventricular Functions And Heart Rate Variability In Dogs With Pulmonic Valvular Stenosis, Ploypanut Trikhun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Pulmonic valvular stenosis (PS) is one of the most common congenital heart diseases in dogs that can lead to the cardiac maladaptation. Also, PS can affect the cardiac autonomic nervous system (ANS). However, clinical information regarding to systolic function and cardiac ANS alteration in PS dogs had not been fully elucidated. The objectives of this study were to evaluate cardiac electrical property, left ventricular (LV) function, and to assess cardiac ANS from heart rate variability (HRV) analysis in PS dogs compared with healthy dogs. The dogs in this study were divided into 2 groups, PS dogs (n=13) and healthy control …

Adjustment Of Maximum Likelihood Method For Multivariate Fay-Herriot Model, Annop Angkunsit

Chulalongkorn University Theses and Dissertations (Chula ETD)

The most widely used area-level model in small area estimation is the Fay-Herriot model, proposed by Fay and Herriot. It was used first to estimate average per capita income for small places (population less than 1,000) of the USA. In the context of the Fay-Herriot model, the traditional method in obtaining estimation of the population mean is the empirical best linear unbiased prediction (EBLUP) estimator. The estimate can be expressed as a weighted sum of the direct survey estimator and regression estimator. One problem that has received attention is the estimation of variance of the area random effects in the …

First Order Integer-Valued Autoregressive Model With A Two-Parameter Generalized Poisson-Lindley Distribution, Suchiraporn Bunyaris

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this study, we introduce the first order integer-valued autoregressive models for count data with the two-parameter generalized Poisson-Lindley distribution. The thinning operators considered in this study are the binomial and negative binomial thinning operators. Some important probabilistic and statistical properties such as moments, stationarity and autocorrelation functions are derived. Moreover, parameter estimations and numerical simulations to examine the constructed model are performed. Finally, applications of the models for real data sets are also discussed.

Argonaute 4 Promotes Genomic Methylation, Kanwalat Chalertpet

Chulalongkorn University Theses and Dissertations (Chula ETD)

RNA-directed DNA methylation (RdDM) is the major small RNA-mediated epigenetic pathway in plants. Similar to genome and epigenome editing with the CRISPR-Cas9 system, RdDM is composed of a regulatory protein and a “guide” RNA (gRNA), which recruits the complex to specific genomic locations containing DNA sequences homologous to the RNA sequence. In humans, we found that Argonaute-4 (AGO4) colocalization has a strong correlation to promoter methylation of AGO4-binding genes. Here, we engineered cell-penetrating tagged oligoarginines (R9) tagged AGO4 (R9-AGO4) or xentry tagged AGO4 (X-AGO4) loaded with single guided-RNA (sgRNA) as a tool to specifically add methylation at genome locations where …

Serum Non-Coding Rna Levels As Potential Diagnostic And Prognostic Markers Of Hepatocellular Carcinoma, Pornpitra Pratedrat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Hepatocellular carcinoma (HCC) is one of the most common type of liver cancers in the world. Most common cause of HCC is viral hepatitis B infection (HBV). That lead to HCC detection at late stage and be difficult for curative treatment. So, biomarkers for HCC are required to detect HCC efficiently. MicroRNAs and long non-coding RNAs (lncRNAs) play a key role in tumorigenesis through many different mechanisms. Moreover, non-coding RNA can be released into body fluid. Hence purpose of this study is to investigate the level of miRNA and lncRNAs in serum as the used as potential biomarkers for HBV-HCC …

Role Of Neutrophils In Osteoarthritis And Rheumatoid Arthritis And Their Metabolomics, Dong Zhan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: Fibroblast-like synoviocytes (FLS) plays a function in the development of synovitis in osteoarthritis (OA) and rheumatoid arthritis (RA). Neutrophil-derived microvesicles (NDMV) can protect cartilage and possess anti-inflammatory effects on recipient cells. We investigated the expression of inflammatory cytokines produced by TNFα-stimulated FLS which were pre-treated with NDMV. Methods: FLS isolated from the synovium of patients with OA were characterized by flow cytometry. Neutrophils were isolated from healthy volunteer blood and were characterized by cytospin and flow cytometry. NDMV, generated from TNFα-stimulated neutrophils, were characterized by electron microscopy, nanoparticle tracking analysis and flow cytometry. MicroRNA of NDMV were sequenced by …

The Effect Of 1’ Acetoxychavicol Acetate On Cell Proliferation, Metastasis, And Angiogenesis In Human Endocrine-Resistant Breast Cancer Cells, Nalinee Pradubyat

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Oestrogen receptor (ER)-positive breast cancer patients have a good prognosis, but 30% of these developed resistance through hyperactivation of PI3K/AKT, ERK1/2, and NFκB, which interconnected with ER signalling. In this study, the effects of 1’ acetoxychavicol acetate (ACA), a plant-metabolite acetate ester compound with an NF-kB inhibitory activity, were investigated in a panel of endocrine-resistant breast cancer cells. Methods: Plant material was purified by chromatographic methods and followed by structural identification using nuclear magnetic resonance and mass spectroscopy. In vitro and in vivo antiproliferative effects of ACA were studied in MCF7/LCC2 and MCF7/LCC9 endocrine-resistant cells using the MTT assay …

Enhanced Propagation Yield Of Influenza Viruses For Vaccine Production Through Cellular Micrornas Regulation, Suthat Saengchoowong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Annual influenza vaccination aims to prevent influenza virus infection thus reduce the incidence of infection and disease in humans. Nowadays, Madin–Darby canine kidney (MDCK) cell culture-based system has been approved as an alternative for influenza vaccine production. Although cellular microRNAs may play an important role in controlling the replication of viruses, the interaction between human seasonal influenza viruses and host microRNAs has not been investigated in this permissive cell line. The primary objective of this study is to improve the yield of seasonal influenza virus (i.e. vaccine virus) production via manipulation of the host microRNAs. MDCK cells were infected with …

Angiogenic Effect Of Salt-Leached Thai Silk Fibroin Scaffolds With Human Adipose-Derived Stem Cells, Tanapong Watchararot

Chulalongkorn University Theses and Dissertations (Chula ETD)

Angiogenesis plays important role in tissue regeneration. Biomaterials that allow and promote angiogenesis are thus beneficial. Silk fibroin (SF) scaffolds are good candidates for angiogenesis activation because of the biodegradability, biocompatibility, and interaction of extracellular matrices. Human adipose-derived stem cells (ADSCs) are also promising for tissue regeneration. This study thus aims to investigate the angiogenic potential of SF scaffolds with/without ADSCs on chick chorioallantoic membrane (CAM). Firstly, the SF scaffolds were fabricated with a porosity of 77.34 ± 16.96% and a pore diameter of 513.95 µm. Then, ADSCs were seeded on SF scaffolds (SF-ADSC scaffolds) and placed on CAM on …

Antioxidant And Antibacterial Agents From Parmotrema Dilatatum (Vainio) Hale, Knema Angustifolia (Roxb.) Warb. And Persicaria Odorata Lour, Asshaima Paramita Devi

Chulalongkorn University Theses and Dissertations (Chula ETD)

In the search of antioxidant and antibacterial agents, the extracts and isolated compounds from lichen Parmotrema dilatatum, Knema angustifolia full name, Persicaria odorata and Mansonia gagei. were examined. Nine compounds were isolated from lichen P. dilatatum including (E)-2,4-dihydroxy-6-methyl-3-(3-oxobut-1-en-1-yl)benzoate (PD.1), hopane-16ß,22-diol (PD.2), methyl orsellinate (PD.3), methyl haemmatomate (PD.4), methyl ß-orcinolcarboxylate (PD.5), 2-hydroxy-4-methoxy-3,6-dimethylbenzoic acid (PD.6), atranol (PD.7), atranorin (PD.8) and lecanorin (PD.9). The dichloromethane and acetone fractions, and atranol (PD.7) gave excellent activities as antioxidants. While in tyrosinase activity the dichloromethane fraction and atranorin (PD.8) showed the highest inhibition. For α-glucosidase inhibition activity, the methanol fraction and methyl haemmatommate (PD.4) revealed the …

Screening And Identification Of Probiotic Lactic Acid Bacteria From Plant Samplesd, Ratthanatda Nuhwa

Chulalongkorn University Theses and Dissertations (Chula ETD)

Seventy lactic acid bacteria (LAB) were isolated from flowers (17 strains), 3 tree barks (7 strains), one fruit (2 strains), ten fermented tea leaves (31 strains) and two silage (13 strains). They were identified as Lactobacillus pentosus (12 strains), L. plantarum subsp. plantarum (9 strains), L. paracasei subsp. tolerans (5 strains), L. brevis (1 strain), L. silagincola (1 strain), L. kunkeei (1 strain), and L. formosensis (1 strain), Enterococcus durans (3 strains), E. lactis (2 strains), E. faecalis (1 strain), E. faecium (1 strain), E. gallinarum (1 strain) and E. gilvus (1 strain), Pediococcus acidilactici (1 strain) and P. pentosaceus …