Digital Commons Network^™

Magnetic Nanoparticles For Hyperthermia For Cancer Treatment, Bianca Paola Meneses Brassea

Open Access Theses & Dissertations

Fe3O4 and NixCu4-x magnetic nanoparticles were synthesized using supercritical conditions of liquids and wet chemistry, respectively. Characterization methods (VSM, SEM, TEM, and magnetic hyperthermia) yielded results that prove feasibility for magnetic hyperthermia for cancer treatment.

Potential Of Nanoscale Elements To Control Fusarium Wilt Disease In Tomato (Solanum Lycopersicum), Enhance Macronutrient Use Efficiency, And Increase Its Yield, Ishaq Olarewaju Adisa

Open Access Theses & Dissertations

Nanotechnology has a great potential in ensuring food production, security and safety globally. Over the past decade, research on the use of nanomaterials to supply nutrient elements and protect plants from pest and diseases has significantly increased. Tomato (Solanum lycopersicum) is one of the most consumed vegetables in the world and United State is one of its largest producers globally generating billions of dollars annually in revenue.. Tomato plants are affected worldwide by Fusarium wilt caused by Fusarium oxysporum f. sp. Lycopersici. There is growing concern about excessive use of conventional pesticides in controlling Fusarium and other diseases in tomato …

Under The Skin: Psychophysiological Consequences Of Racial Discrimination, Miriam Josephine Alvarez

Open Access Theses & Dissertations

Background. Attitudes toward one's ethnic group can have particular implications for health functioning among groups that are misrepresented or discriminated against by societal institutions. The present experiments tested the consequences of experiencing racism on psychophysiological stress and executive function. Resilience and ethnic identity are examined as a protective factors. Specifically, Experiment 1 testes how discrimination impacts (1) anxiety, (2) heart rate, (3) working memory, and (4) the role of resilience as a protective factor. Experiment 2 sought to (1) replicate Experiment 1, (2) explore the interaction of ethnic identification and perceived prejudice on stress among Latinxs, and (3) establish a …

Computer-Aided Classification Of Impulse Oscillometric Measures Of Respiratory Small Airways Function In Children, Nancy Selene Avila

Open Access Theses & Dissertations

Computer-aided classification of respiratory small airways dysfunction is not an easy task. There is a need to develop more robust classifiers, specifically for children as the classification studies performed to date have the following limitations: 1) they include features derived from tests that are not suitable for children and 2) they cannot distinguish between mild and severe small airway dysfunction.

This Dissertation describes the classification algorithms with high discriminative capacity to distinguish different levels of respiratory small airways function in children (Asthma, Small Airways Impairment, Possible Small Airways Impairment, and Normal lung function). This ability came from innovative feature selection, …

Raman Computational And Experimental Studies On Label-Free Biological Investigations, John Ciubuc

Open Access Theses & Dissertations

Raman spectroscopy is an optical technique that allows for label-free biological investigations to take place. This approach presents both new perspectives and a means for visualizing investigations. This thesis confronts two biological cases: dopamine (DA) detection at physiological levels and assessment of renal osteodystrophy (ROD). We employed surface-enhanced Raman spectroscopy on silver nanoparticles recording DA concentrations as low as 10−11 molar. Quantum chemical density functional calculations were carried out using Gaussian-09 analytical suite software. Good agreement between the simulated and experimentally determined results indicates the existence of distinct DA molecular forms, such as uncharged DA±, anionic DA−, and dopaminequinone. Disappearance …

U.S. Perceptions Of Economic Mobility Since The Enactment Of Nafta And Their Impact On American Politics And Society, Jairemy Quinton Edwards

Open Access Theses & Dissertations

In this study, I examine how perceptions of NAFTA developed over 20 years since its enactment, measured as perceived economic mobility in 2016, have affected more recent public perceptions leading to increased, controversial tendencies towards nationalism, protectionism, and pessimism about the future of the U.S. economy. I then assess whether and how such perceptions in turn may have affected voter perceptions about Donald Trump, setting the stage for his 2016 election victory. Therein, I have found that among U.S. voters in 2016, those with perceptions of reduced economic mobility since the enactment of NAFTA were significantly more likely to have …

Assessing Delamination Of Concrete Bridge Decks With Aging In Arid Regions Using Nondestructive Testing Methods, Melissa Escalante

Open Access Theses & Dissertations

Bridge decks usually experience deterioration at a more rapid pace than other infrastructure components due to the heavy traffic loads and environmental conditions that the deck sustains. Delamination within concrete bridge decks accelerates due to water and deicing salts penetrating the concrete; resulting in the corrosion of reinforcing steel. The corrosion of rebar may result in a fracture parallel to the surface of the concrete structure at the top of the reinforcement layer. The delamination is then subjected to expansion over a large span; risking the overall stability of the structural element. Health monitoring of concrete bridge decks is therefore …

The Role That Language Proficiency Variables Play On Grammaticality, Morphosyntax, And Semanitc Skills In Bilingual Children, Stephanie Escobar

Open Access Theses & Dissertations

Purpose: A number of experiential factors contribute to bilingual development. Factors such as opportunities to hear and use language, age of first exposure, context of learning, social value of a language, education and others have been discussed in other studies. (Bedore et al 2016; Bedore et al 2012). Language questionnaires and self-reports have been used to quantify language variables and current usage of a language. The current study was part of a larger project examining diagnostic accuracy of various assessment tools for Spanish English bilingual children living in a US/Mexico border city (Curtis, Summers, Stubbemann, & Smith, 2017). The purpose …

Application Of Urinary Metabolites For Cancer Detection, Qin Gao

Open Access Theses & Dissertations

Prostate cancer (PCa) is the 3rd most common cause of male cancer mortality in the US. Early diagnosis and treatment of PCa will improve the quality of care and reduce mortality. The prostate specific antigen (PSA) is commonly used in the current PCa screening, but its limitation has resulted in an intense search for more reliable biomarkers. Studies showed that dogs could differentiate PCa patients from negative control by sniffing their urine. As the odor profiles are generated by volatile organic compounds (VOCs), the finding suggests that particular VOCs could be linked to PCa, PCa risk levels and other cancers. …

Lenders' Influence On Borrower Firms' Internal Controls, Md Mahmudul Hasan

Open Access Theses & Dissertations

I identify a covenant in commercial loan contracts that requires borrowers to provide lenders internal control-related private information. Lenders use accounting information to monitor loan contracts and reliable accounting information is dependent on effective internal controls of the firm. I argue and provide evidence that lenders are more likely to demand internal control-related private information when borrowers have weak internal controls, when lenders use more accounting information in debt contracts, and when debt contracts have terms that expose lenders to greater risk. I further show that lenders' demand for internal control-related private information is positively associated with improvement in borrower …

Assessing The Predictive Utility Of The Positive Achievement Change Tool At A Texas Juvenile Justice Agency, Elizabeth Perez Hutchins

Open Access Theses & Dissertations

In the United States, millions of youth are processed in the juvenile justice system each year. Juvenile probation officers, case managers, and clinicians have the daunting task of making critical case-processing decisions for this vulnerable population including program placement, supervision, and treatment. Moreover, juvenile justice professionals must be mindful of numerous factors such as risk to public safety and the juvenile's risk to reoffend when making these decisions. In recent years, juvenile justice agencies have employed the Risk-Need-Responsivity model, the pre-eminent evidence-based model for offender assessment and management, to aide in the decision-making process. Although implementation of risk assessment tools …

Development Of Ligand-Kinase Binding Affinity Predictive Model, Govinda Kc

Open Access Theses & Dissertations

Prediction of interaction between drugs or drug like compounds and targets, is of high importance in drug discovery process as it provides important insights into therapeutic potential and possible adverse effects. As the experimental testing would be highly expensive, laborious and time consuming, screening the molecules computationally before performing experiments would be cost effective, faster and convenient as a method of approach. In this study, I have developed computational models, leveraging machine learning techniques, to predict drug-kinase binding affinities. The predictive model is mainly built using the Random Forest (RF) machine learning method. This study is focused on kinases because …

A Bottom-Up Modeling Methodology Using Knowledge Graphs For Composite Metric Development Applied To Traffic Crashes In The State Of Texas, Daniel Michael Mejia

Open Access Theses & Dissertations

Data is a key factor for understanding real-world phenomena. Data can be discovered and integrated from multiple sources and has the potential to be interpreted in a multitude of ways. Traffic crashes, for example, are common events that occur in cities and provide a significant amount of data that has potential to be analyzed and disseminated in a way that can improve mobility of people, and ultimately improve the quality of life. Improving the quality of life of city residents through the use of data and technology is at the core of Smart Cities solutions. Measuring the improvement that Smart …

Women Legislators & Representation Of The Indigenous Interests: The Case Of Mexico, Michelle Muñoz Cisneros

Open Access Theses & Dissertations

Elsa Chaney (1979) argued that women legislators in Latin America exhibit a supermadre approach in their legislatures. As a result of this, women legislators are relegated to "less important" committees, such as those dealing with family, children, and social issues. Based on her approach, this Thesis argues that due to gender socialization women legislators create an inclusive political environment in the legislature for minorities and marginalized groups. Specifically, it investigates women legislators' bill initiation behavior regarding the inclusion of indigenous populations' interests. This Thesis analyzes original data gathered from the 2009-2018 Mexican Congress using logistic regression. The findings indicate that …

Ghosts Of Madmen: A Generational Tale, Kristen Leigh Olin

Open Access Theses & Dissertations

A family story depicting an immigrant family that must deal with the horrors of the past while delving through the psyche of the present. One woman's look into the deepest reaches of her American family and their generations of alcoholism and abuse and her resolution to the ghosts that haunt the family's women.

Social Cohesion Among Individuals Participating In Re-Entry Groups, Todd Reiser

Open Access Theses & Dissertations

When prisoners are released from incarceration they enter a social landscape that holds unique challenges. One of the ways humans living within social systems understand their place and role is through the mechanism of religion. This study investigates how group religious practice establishes a shared worldview among those recently released from prison; a worldview that promotes the creation of positive social cohesion which contribute to life improvements, social mobility, and social status changes. "Social networks may include friendship circles in local congregations, scripture study groups and relationships with religious leaders who serve as role models for individuals" (Kerley et al …

The Illusion Of An Abundant End- A Phenomenological Approach To Sustainability: The Progress Trap And The Transformative Potential Of Dialogue, Shantanu Rojatkar

Open Access Theses & Dissertations

Abundance is a concept according to which a thing is deemed to be in plenty. The feeling of satisfaction and assurance, arising from something that is concretely abundant, serves as a material reason for motivation of a desired action. Just like the stock of food lying in our fridge, ensuring more than just the needs of the moment, the abundance cooks the taste of freedom, freedom from worrying about tomorrow. However, over consumption out of greed as a potential outcome of abundance, could result in the increased capacity of a person in order to reach the initial level of satisfaction. …

Ultrafine Black Carbon: A Cumulative Assessment On The Physiology Of Lung - Derived Cells, M Esther Salinas

Open Access Theses & Dissertations

Combustion-derived nanomaterials are noxious ultrafine (<100 nm) aerosolized by-products generated by human activity. They pose threats to pulmonary health due to their small size, allowing them to penetrate deep into the alveolar regions causing detrimental responses downstream. Indeed, an examination between nanocarbon particle exposure and poor pulmonary health via cellular behavior was needed. I hypothesized that low-dose and long-term administrations of carbonaceous nanoparticles contribute to respiratory conditions by irritating lung-derived cells. Responses to ultrafine black carbon (UBC), a key component of airborne pollutants, by human lung A549 and murine lung LA4 epithelial cells, human peripheral-blood monocytes THP1, and murine macrophages RAW264.7 were investigated. These lines were chosen because epithelial cells and mononuclear cells (monocytes and macrophages) are the first to come in contact with inhaled particulate matter (PM) and contribute to stress and inflammation of pulmonary tissues. The cells were first plated on day zero and fed fresh UBC suspended in culture media on days one, four, and seven. The exposure regimen included three different low-level concentrations of UBC. On day ten, all cells were prepared for subsequent assays. Effects on cellular viability revealed that UBC was modestly cytotoxic while ATPase and esterase activity (termed enzyme vitality for the purpose of this study) were significantly diminished in a dose-dependent manner. Additionally, beta-galactosidase proportionally increased with UBC concentration compared to untreated cells, indicating that cellular senescence was promoted across all cell types. Multiple markers of oxidative stress were subsequently measured, showing non-uniform trends and displaying moderate accumulation of oxidative damage, contingent upon cell line and UBC treatment. However, a significant induction of inner mitochondrial membrane depolarization of human UBC-treated cells was observed; an aberrant cell-cycle progression was found across all cells. The implemented regimen of UBC exposure elicited an imbalance of free (reduced) glutathione, altered mitochondrial potential, and abnormal cell-cycle activity. This method demonstrated that modifications across both species induced changes to cellular fitness overall. The data supported that compounding nanosized black carbon exposure could negatively affect overall pulmonary cell health by distinctively modifying intracellular activity. Additionally, we further surmised that sustained exposure to nanocarbon could impair innate immunity. Therefore, reactive oxygen species (ROS), reactive nitrogen species (RNS), and cytokine levels upon continuous administrations to 3.0 μg/mL UBC after brief challenges to microbial proxies were assessed; on day 9, the cells were succumbed to three different microbial insults (LPS, Poly I:C, and Zymosan). On day 10, measurements demonstrated a moderate accumulation of oxidative stress, conditional to each cell type. Thus, UBC plus microbe approach triggered pro-oxidant levels and cytokine production across different cell types and diminished phagocytic response by murine macrophages. Based on the results, ultrafine-PM exposure may impair inflammatory function in response to pathogenic infections. In summation, our findings indicated that additive nanosized UBC in combination with microbe-like challenges may compromise cellular behavior, suggesting potential ways by which inhalation of ultrafine-PM may contribute to or exacerbate poor pulmonary health.

Attitudes And Barriers Affecting Hearing Aid Use In Hispanics Living In The U.S. Borderland Region, Loren Renee Sotelo

Open Access Theses & Dissertations

Hearing loss can affect a person's overall quality of life, and has been linked to depression and dementia in older adults (Brewster, Ciarleglio, Brown, Chen, Kim, Roose, Golub & Rutherford, 2018; Ciorba, Bianchini, Pelucchi, & Pastore, 2012). In the largest study to date of hearing loss among Hispanic adults residing in the U.S., researchers found that nearly 1 in 7 has hearing loss, which is close to the overall national average (National Institutes of Health, 2015). Currently, hearing aids are the primary/most effective treatment for an age-related hearing loss; Unfortunately, the adult uptake rates are low (Chien & Lin, 2012; …

Investigation Into The Effects Of Copper Based Nanoparticles On Sugarcane (Saccharum Officinarium) And Zucchini (Cucurbita Pepo), Carlos Tamez

Open Access Theses & Dissertations

The widespread use of copper-based nanomaterials has been accompanied by an increasing interest to understand their potential risks. Due to high surface area to volume properties, nanomaterials are more reactive than their bulk counterparts. Copper nanoparticles are used in numerous products, and could enter the environment through their synThesis or incidental use. It is essential to understand the effects of nanoparticles on edible crops by performing both short-term and long-term experiments at relevant exposure concentrations. In order to evaluate biochemical and physiological effects crops, sugarcane and zucchini, were grown in soil amended with: Kocide 3000 (copper-based fungicide), nano-sized CuO (nCuO), …

Spectroscopic Analysis Of Calcium Oxalate Kidney Stone Inhibition By Nordihydroguaiaretic Acid (Ndga), Mahendra Subedi

Open Access Theses & Dissertations

This current study provides information regarding the inhibition of calcium oxalate type of kidney stones by the use of nordihydroguaiaretic acid (NDGA). Around 80% of kidney stones found in patients are principally made of calcium oxalate and calcium phosphate. NDGA is an antioxidant compound that is chemically extracted from the desert bush Larrea tridentata. This work is a logical continuation of a previous research, where different concentrations of Larrea tridentata extract were used for such inhibition. Size and morphological changes from a calcium oxalate monohydrate (COM) structure to a calcium oxalate dihydrate (COD) structure were previously reported.

In the current …

Fishers' Ecological Knowledge And Stable Isotope Analysis: A Social-Ecological Systems Approach To Endangered Species Conservation, Kathryn Rose Wedemeyer-Strombel

Open Access Theses & Dissertations

Identifying developmental habitat is essential for understanding population structure and species resiliency, especially for critically endangered species. In long-lived, oceanic, migratory animals such as sea turtles, elucidating developmental grounds is particularly difficult. When data are deficient or challenging to acquire, scientists often lean towards traditional quantitative methods when a social-ecological systems approach could better provide crucial baseline data and guiding information. Fishers’ ecological knowledge (FEK), the combination of experiential and culturally transmitted knowledge, is expert knowledge and should be treated as such. In 2008, FEK led to the “rediscovery” of the critically endangered eastern Pacific (EP) population of hawksbill sea …

Nonvoting Shares And Efficient Corporate Governance, Dorothy S. Lund

Faculty Scholarship

A growing number of technology companies, including Google, Zillow, and Snap, have issued stock that does not allow investors to vote on corporate decisions. But there is fundamental disagreement among scholars and investors about whether nonvoting stock is beneficial or harmful. Critics argue that nonvoting shares perpetually insulate corporate insiders from influence and oversight, and therefore increase agency costs. By contrast, proponents contend that nonvoting shares may provide benefits that exceed these agency costs, such as enabling corporate insiders to pursue their long-term vision for the company without interference from outside shareholders.

This Article offers a novel perspective on this …

Newcomer English Language Learners In High School Choral Music Education: An Ethnographic Case Study, Lisa Ann Serna

Open Access Theses & Dissertations

This five month long ethnographic case study seeks to add to the limited literature on Newcomers enrolled in choir (Carlow, 2006), by understanding the role a focused choral music education plays in their ability to listen, speak, read, and write in the English language. The study also seeks to contribute to the literature connecting language learning and choral music education. The purpose of the study was to understand Newcomer English language learners' (NELs) experiences of practice and performance in high school choir, as it relates to language learning and social belonging. Cultural Historical Activity Theory framed my study which allowed …

A Comparative Study Of College Students’ Cultural Orientation, Aging Attitude, And Anxiety: Japan, China, And Usa., Hiroko Tomioka, Ginny Q. Zhan, Sharon M. Pearcey

Faculty Articles

The current study compared responses from young people on cultural orientation, aging attitudes, and aging anxiety in Japan, China, and the United States. A total of 1,136 college students (357 Japanese, 434 Chinese, and 345 American) filled out a questionnaire that included an IC Scale (Cultural Orientation Scale), Kogan’s Attitudes toward Old People Scale, and a modified Aging Anxiety Scale, in addition to demographic information. Cronbach’s alphas indicated satisfactory reliability on all three scales for the three groups. The results indicate that the Japanese were significantly more collectivistic than both the Chinese and American participants, but the three groups all …

Showcase Panel I: What Is Regulation For?, Richard Epstein, Philip A. Hamburger, Kathryn Kovacs, John D. Michaels, Britt Grant

Faculty Scholarship

2018 National Lawyers Convention Transcripts

“The administrative state, with roots over a century old, was founded on the premise that Congress lacked the expertise to deal with the many complex issues facing government in a fast-changing country, and that it was unhelpfully mired in and influenced by politics, leading to bad outcomes when it did act. The alternative was to establish administrative agencies, each with assigned areas of responsibility, housing learned experts qualified to make policy decisions, deliberately insulated from political accountability. The Administrative Procedure Act (APA), passed in 1946, both governs the manner in which agencies may adopt and …

Assessing Aspects Of Acculturation In A Muslim American Sample: Development And Testing Of The Acculturation Scale For Muslim Americans, Anisah Bagasra, Mitchell Mackinem

Faculty Articles

Acculturation of Muslims into the American culture continues to be a topic of deep interest. The purpose of this study was to examine acculturation in a sample of both American-born and Immigrant Muslim Americans. Two hundred and fifty five Muslim Americans completed a scale designed to assess two aspects of acculturation within the population: adherence to Islamic identity and conformity to American social norms. The survey was distributed in both a paper-based and online anonymous format consisting of demographic questions and the acculturation scale designed for this study. Results revealed that both immigrants and U.S. born Muslim Americans demonstrate a …

Environmental Law, Travis M. Trimble

Scholarly Works

In 2017,1 district courts in the United States Court of Appeals for the Eleventh Circuit decided three cases that clarified issues arising under the Clean Water Act (CWA). 2 The United States District Court for the Southern District of Georgia preliminarily enjoined the Environmental Protection Agency (EPA) and the Army Corps of Engineers from enforcing the Waters of the United States Rule (WOTUS Rule), 3 a regulatory attempt to define the term "Waters of the United States," which is a jurisdictional threshold for agencies' regulatory authority under the CWA.4 Also, the United States District Court for the Northern District of …

Social Vulnerability Assessment Of Dog Intake Location Data As A Planning Tool For Community Health Program Development: A Case Study In Athens-Clarke County, Ga, 2014-2016, Lisa Milot, Jessie Lee Dyer

Scholarly Works

A retrospective spatial analysis of dog intake data from an open admission animal shelter in Georgia was conducted to explore patterns within dog demographics and outcomes by pickup location or by the home address of the person who transferred ownership rights of the dog to Athens-Clarke County Animal Control during the period 2014–2016. Spatial analysis found the relationship between these intake locations and the final disposition of the dogs to be non-random, suggesting social and environmental influences on distribution. Statistically significant clusters were identified using the Getis-Ord Gi* statistic. This study found statistically significant hot spots (i.e., areas with higher …

Code Revision Commission V. Public.Resource.Org And The Fight Over Copyright Protection For Annotations And Commentary, David E. Shipley

Scholarly Works

This article is about the Eleventh Circuit’s 2018 decision in Code Revision Commission v. Public.Resource.Org concerning the public edicts doctrine and holding that the State of Georgia’s copyright on the annotations, commentary and analyses in the Official Code of Georgia Annotated is invalid. About a third of the States claim copyright in the annotations to their codes so the potential impact of this decision is substantial. The U.S. Supreme Court granted Georgia’s petition for a writ of certiorari on Monday, June 24.

The article’s thesis is that the Eleventh Circuit was wrong and should be reversed. It first discusses the …