Digital Commons Network^™

Sofosbuvir/Velpatasvir For 12 Weeks In Hepatitis C Virus-Infected Patients With End-Stage Renal Disease Undergoing Dialysis, Sergio M. Borgia, Janet Dearden, Eric M. Yoshida, Stephen D. Shafran, Ashley Brown, Ziv Ben-Ari, Matthew E. Cramp, Curtis Cooper, Matthew Foxton, Conrado Fernandez Rodriguez, Rafael Esteban, Robert Hyland, Sophia Lu, Brian J. Kirby, Amy Meng, Svetlana Markova, Hadas Dvory-Sobol, Anu O. Osinusi, Rafael Bruck, Javier Ampuero, Stephen D. Ryder, Kosh Agarwal, Raymond Fox, David Shaw, Shariq Haider, Bernard Willems, Yoav Lurie, Jose Luis Calleja, Edward J. Gane

Peninsula Medical School

BACKGROUND & AIMS: Although off-label use of sofosbuvir-containing regimens occurs regularly in patients with hepatitis C virus (HCV) infection undergoing dialysis for severe renal impairment or end-stage renal disease (ESRD), these regimens are not licensed for this indication, and there is an absence of dosing recommendations in this population. This study evaluated the safety and efficacy of sofosbuvir/velpatasvir in patients with HCV infection with ESRD undergoing dialysis. METHODS: In this phase II, single-arm study, 59 patients with genotype 1-6 HCV infection with ESRD undergoing hemodialysis or peritoneal dialysis received open-label sofosbuvir/velpatasvir (400 mg/100 mg) once daily for 12 weeks. Patients …

Belonging In Brexit Britain: Central And Eastern European 1.5 Generation Young People's Experiences, Naomi Tyrrell, Daniela Sime, Claire Kelly, Christina Mcmellon

School of Geography, Earth and Environmental Sciences

No abstract provided.

163 Development Of Clinical And Patient-Reported Quality Metrics For Multiple Sclerosis: A Uk Pilot Study Report, G Giovannoni, S White, N Mistry, S Calhoun, C Young, M Coutts, M Roberts, P Anderson, R Bernstein, J Hobart

Peninsula Medical School

BackgroundQuality standards (QS) for people with multiple sclerosis (PwMS) are suboptimal, ambiguous and restricted to certain patient subgroups and care pathways.AimDevelop and pilot MS metrics measuring service provision quality to identify areas for improvement.MethodsA multidisciplinary Working Group developed clinician and patient-reported metrics and standardised data collection forms through an iterative process.ResultsMetrics covered: referral; diagnosis; treatment; annual review; general management; education. Pilot (n=76) showed: 31% of PwMS were referred to MS specialist within 4 weeks of suspected/confirmed demyelination; 28% and 56% had uncomplicated MS confirmed and were offered specialist MS nurse appointment, respectively, within 4 weeks of specialist referral; 75% of …

Impacts Of The Mycotoxin Zearalenone On Growth And Photosynthetic Responses In Laboratory Populations Of Freshwater Macrophytes (Lemna Minor) And Microalgae (Pseudokirchneriella Subcapitata)., Ej Eagles, R Benstead, S Macdonald, R Handy, Th Hutchinson

School of Biological and Marine Sciences

Mycotoxins are an important class of chemicals of emerging concern, recently detected in aquatic environments, potentially reflecting the influence of fungicide resistance and climatic factors on fungal diseases in agricultural crops. Zearalenone (ZON) is a mycotoxin formed by Fusarium spp. and is known for its biological activity in animal tissues; both in vitro and in vivo. ZON has been reported in US and Polish surface waters at 0.7 - 96 ng/L, with agricultural run-off and wastewater treatment plants being the likely sources of mycotoxins. As some mycotoxins can induce phytotoxicity, laboratory studies were conducted to evaluate the toxicity of ZON …

Effects Of Historic And Projected Climate Change On The Range And Impacts Of An Emerging Wildlife Disease, Stephen J. Price, William T.M. Leung, Christopher J. Owen, Robert Puschendorf, Chris Sergeant, Andrew A. Cunningham, Francois Balloux, Trenton W.J. Garner, Richard A. Nichols

School of Biological and Marine Sciences

No abstract provided.

Differential Immunity As A Factor Influencing Mussel Hybrid Zone Structure, Deryk Tolman, Hannah L. Wood, David O.F. Skibinski, Manuela Truebano

School of Biological and Marine Sciences

No abstract provided.

Patterns Of Polypharmacy Before Diagnosis Of Dementia: A Data-Driven, Retrospective, Population-Based Study With Primary Care Electronic Health Records, E Longo, L Huo, B Burnett, J Demmler, A Morris, S Brophy, Ra Lyons, S-M Zhou

School of Nursing and Midwifery

No abstract provided.

Is The Court Of Justice Of The European Union Finding Its Religion?, Philippa Watson, Peter Oliver

Fordham International Law Journal

No abstract provided.

The Frand Ceremony And The Engagement Of Article 102 Tfeu In The Licensing Of Standard Essential Patents, Jeffery Atik

Fordham International Law Journal

No abstract provided.

European Union Law And International Arbitration At A Crossroads, George A. Bermann

Fordham International Law Journal

No abstract provided.

From Retribution To Restoration: Implementing Nationwide Restorative Justice Initiatives - Lessons From Jamaica, Inga N. Laurent

Fordham International Law Journal

No abstract provided.

National Security And Economic Globalization: Toward Collision Or Reconciliation?, J. Benton Heath

Fordham International Law Journal

No abstract provided.

A Proposal For “Rebalancing” To Deal With “National Security” Trade Restrictions, Simon Lester, Huan Zhu

Fordham International Law Journal

No abstract provided.

Countervailing Social Dumping—Regulating Ill Gotten Economic Gains, Ruarri Rogan

Fordham International Law Journal

No abstract provided.

The European Road To Autonomous Vehicles, Francesco Paolo Patti

Fordham International Law Journal

No abstract provided.

Protecting Religious Freedom And Conscience: What Australia Might Learn From Germany, Patrick T. Quirk

Fordham International Law Journal

No abstract provided.

The Counter-Associational Revolution: The Rise, Spread, And Contagion Of Restrictive Civil Society Laws In The World’S Strongest Democratic States, Chrystie F. Swiney

Fordham International Law Journal

No abstract provided.

Nutritional Education Program Using The Dash Diet For African Americans, Angela B. Williams

Walden Dissertations and Doctoral Studies

Hypertension (HTN) is a serious yet common condition that can be prevented or

controlled. Complications of uncontrolled HTN can lead to cardiac failure, renal disease,

and stroke. In the United States, HTN is greater among African Americans than any other

ethnic group and is prevalent in the community in which this project was conducted. To

address the problem of HTN and its effect on members of the African American (AA)

population in the site community, a program of HTN self-management emphasizing

patient education and healthy behaviors for the AA community was developed. The

purpose of this project was to search …

Fair And Impartial Adjudication, Thomas W. Merrill

Faculty Scholarship

Any legal system that purports to respect the rule of law must ensure the fair and impartial adjudication of disputes under the law. Classic accounts of the rule of law assume that courts should resolve such disputes. However, this is too narrow. All forms of adjudication, not just by courts, need to be fair and impartial. In any event, no one could claim that courts or entities by that name are always fair and impartial. All legal systems need a guarantee of fair and impartial adjudication that applies to all forms of dispute resolution under law.

A dispute arising under …

New Look Constitutionalism: The Cold War Critique Of Military Manpower Administration, Jeremy K. Kessler

Faculty Scholarship

By reconstructing the anxious, constitutional dialogue that shaped the administration of military manpower under President Eisenhower’s New Look, this Article explores the role that administrative constitutionalism played in the development of the American national-security state, a state that became both more powerful and more legalistic during the pivotal years of the Cold War. The Article also questions the frequent identification of administrative constitutionalism with the relative autonomy and opacity of the federal bureaucracy. The back-and-forth of administrative constitutionalism continually recalibrated the degree of autonomy and opacity that characterized the draft apparatus. This evidence suggests that bureaucratic autonomy and opacity may …

Factors That Influence Physical Activity Among African American Mothers At Recreation Centers, Nichole Leigh Glover

Walden Dissertations and Doctoral Studies

Physical activity is a critical factor in preventing obesity and other chronic illnesses. African American women experience higher rates of physical inactivity than the general population. As a key figure in the family, African American mothers should model healthy behaviors to the family, especially their children. This qualitative study explored the physical activity attitudes of African American mothers who frequently visit a recreation center in the Columbus, Ohio, area. The research questions focused on the possible barriers and motivators for physical activity engagement. The theory of planned behavior, which emphasizes behaviors, intentions, and attitudes when exploring health behaviors, guided the …

Examining Cultural Humility And Intersectionality In Mental Health Treatment, Sandra Y. Herrera-Spinelli

Walden Dissertations and Doctoral Studies

Cultural awareness is an ethical standard in the social work profession and, as the diversity in the United States continues to grow, it is a social work practice problem when cultural awareness is not implemented in mental health settings. The National Association of Social Workers revised the cultural awareness standards to include cultural humility and intersectionality as practice indicators. The purpose of this action research study was to examine how clinical social workers demonstrated cultural humility and intersectionality in mental health settings. Person-centered theory guided this study and a total of 17 clinical social workers in New Mexico participated in …

The Self-Perceived Cultural Competency Of Hiv Interventionists, Tonya Herring

Walden Dissertations and Doctoral Studies

Despite significant research and inroads with the human immunodeficiency virus (HIV), disparities in HIV infection continue to widen for African American (AA) men who have sex with men (MSM). In recent times, cultural competence has been receiving increased attention as a possible factor to enhance the quality of health messaging and lessening HIV disparities. However, there is a dearth of research specifically dedicated to AA MSM and culturally competent HIV health messages. To address this gap, this qualitative research was designed to investigate the self-perceived cultural competency among HIV counselors. The theoretical framework for the project was the PEN-3 cultural …

Recidivism Differences And Measures Of Predictability For Federally Convicted Child Pornographers, Ricardo J. Rodriguez

Walden Dissertations and Doctoral Studies

There is a gap in research on the effectiveness of mandatory-€minimum sentences on the recidivism rates of federal child pornography offenders, resulting in policy that may be ineffective and costly. Relevant research can further understanding of criminogenic behavior that results in the exploitation of children and aid future policy making decisions. Therefore, the purpose of this study was to better understand the relationship between federal sentencing and federal child pornographer recidivism. Central to this study is the research question of whether there exists a statistically significant difference between the likelihood of recidivism in 2 child pornographer cohorts that receive different …

Exploring How Emdr Social Workers In Eastern Canada Experience Vicarious Trauma, Ashley Amara Spinney

Walden Dissertations and Doctoral Studies

Social workers are increasingly using eye movement, desensitization, and reprocessing (EMDR) to help clients recover from trauma. Little is known about how social workers who work with traumatic client material while using EMDR as their main psychotherapeutic modality experience vicarious trauma. The purpose of this phenomenological study was to explore the experience of vicarious trauma among social workers in Eastern Canada who used EMDR in their practice with clients. Constructivist self-development theory was the framework that informed this study. Data were collected using semistructured interviews with 7 EMDR social work participants who were selected using purposive sampling. Participants were required …

Influence Of Police Officer Fear And Use-Of-Force Outcomes, Michele D. Stafford

Walden Dissertations and Doctoral Studies

Police officer and community relations tensions have heightened with increases in publicized deadly use-of-force incidents on social media platforms. Though some deadly force encounters have been justified because officers stated they feared for their lives, little is known about the impact fear has on police officers' actions. The purpose of this phenomenological study was to explore the impact fear plays when officers implement use-of-force continuum practices during encounters with civilians. Schacter and Singers' two-factor theory of emotion was used as the conceptual framework for this study. The key research question examined the influence of police officer fear as a factor …

Nurse Executives' Lived Experience Of Incorporating Caring Leadership, Rachel Elizabeth Stepp

Walden Dissertations and Doctoral Studies

The link between compassion and caring at all levels of nursing practice and the enhancement of the patient experience is well-documented. However, the techniques nurse executives use to incorporate caring into their daily practice while coping with competing organizational priorities is poorly understood. The purpose of this qualitative phenomenological study, guided by Watson's theory of human caring, was to examine detailed accounts of the experiences of nurse executives incorporating compassion and caring into their daily practice, including techniques they use to build and sustain compassion and caring while balancing competing priorities. A purposive sample of 10 nurse executives participated in …

Root Cause Of Medication Errors In A Pediatric Intensive Care Unit, Louis Gilbert Tingling

Walden Dissertations and Doctoral Studies

Five to 27% of all pediatric medication orders lead to errors and play a significant role in the morbidity and mortality of the pediatric patients admitted to hospitals. The practice problem explored the high rate of medication errors in the pediatric intensive care unit (PICU) of the project site, where the population is particularly vulnerable due to their acute illnesses. The purpose of this project was to analyze the root causes of all cases of medication error in this hospital's PICU during the last 2 years. The literature review was used to categorize secondary data extracted from the hospital's quality …

Resilience Building In Biracial And Multiracial, Bisexual Adults: An Interpretative Phenomenological Analysis, Melissa Gale Swartz

Walden Dissertations and Doctoral Studies

Until recently, society and science often ignored, erased, and avoided bisexual women and men and individuals with biracial and multiracial identities, and rarely considered these identities simultaneously. Prior research has shown that some lesbians and gay people of color exhibit resilience against sexual minority stress due in part to an inoculating effect of exposure to racism earlier in life. However, little is known about the lived experience of thriving, resilient bisexual multiracial individuals. In the tradition of positive psychology and context of intersectionality theory, this qualitative study explored how multiracial bisexual individuals develop and maintain flourishing well-€being despite sociocultural factors …

Trauma-€Informed Care For Persons With Opioid Use Disorder In Ohio, Kimberly Toler

Walden Dissertations and Doctoral Studies

Prevention, social work, and community awareness programs have not led to the successful reduction of opioid overdose deaths nationwide, and particularly in Ohio. This study explored social work perspectives about trauma-€informed care (TIC) for persons with opioid use disorder in Ohio. The research questions for this study examined how social workers in Ohio implemented TIC when providing outpatient treatment to opioid users and what challenges they faced when providing TIC. Using an action research methodology, data were collected through individual semistructured interviews with 5 social work professionals, selected through purposive sampling based on experience in the field of substance use …