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Computational Tools For The Untargeted Assignment Of Ft-Ms Metabolomics Datasets, Joshua Merritt Mitchell

Theses and Dissertations--Molecular and Cellular Biochemistry

Metabolomics is the study of metabolomes, the sets of metabolites observed in living systems. Metabolism interconverts these metabolites to provide the molecules and energy necessary for life processes. Many disease processes, including cancer, have a significant metabolic component that manifests as differences in what metabolites are present and in what quantities they are produced and utilized. Thus, using metabolomics, differences between metabolomes in disease and non-disease states can be detected and these differences improve our understanding of disease processes at the molecular level. Despite the potential benefits of metabolomics, the comprehensive investigation of metabolomes remains difficult.

A popular analytical technique …

City Limits: Heat Tolerance Is Influenced By Body Size And Hydration State In An Urban Ant Community, Dustin Jerald Johnson

University of the Pacific Theses and Dissertations

Cities are rapidly expanding, and global warming is intensified in urban environments due to the urban heat island effect. Therefore, urban animals may be particularly susceptible to warming associated with ongoing climate change. Thus, I used a comparative and manipulative approach to test three related hypotheses about the determinants of heat tolerance or critical thermal maximum (CTmax) in urban ants—specifically, that (1) body size, (2) hydration status, and (3) preferred micro-environments influence CTmax. I further tested a fourth hypothesis that native species are particularly physiologically vulnerable in urban environments. I manipulated water access and determined CTmax for 11 species common …

Immunological Pathways Triggered By Porphyromonas Gingivalis And Fusobacterium Nucleatum: Therapeutic Possibilities?, Kívia Queiroz De Andrade, Cassio Luiz Coutinho Almeida-Da-Silva, Robson Coutinho-Silva

All Dugoni School of Dentistry Faculty Articles

Porphyromonas gingivalis (P. gingivalis) and Fusobacterium nucleatum (F. nucleatum) are Gram-negative anaerobic bacteria possessing several virulence factors that make them potential pathogens associated with periodontal disease. Periodontal diseases are chronic inflammatory diseases of the oral cavity, including gingivitis and periodontitis. Periodontitis can lead to tooth loss and is considered one of the most prevalent diseases worldwide. P. gingivalis and F. nucleatum possess virulence factors that allow them to survive in hostile environments by selectively modulating the host's immune-inflammatory response, thereby creating major challenges to host cell survival. Studies have demonstrated that bacterial infection and the host immune responses are involved …

Special Education Non-Licensure Option, Special Education

Program Revisions/Additions

No abstract provided.

Political Science International Studies Option, Political Science

Program Revisions/Additions

No abstract provided.

Communication Studies Major, Communication And Journalism

Program Revisions/Additions

No abstract provided.

World Languages And Cultures Catalog Changes, World Languages & Cultures

Program Revisions/Additions

No abstract provided.

Bs Ed Ece Education Studies Option, Teaching, Learning, & Foundations

Program Revisions/Additions

No abstract provided.

Bs Ed Ele Education Studies Option, Teaching, Learning, & Foundations

Program Revisions/Additions

No abstract provided.

Bs Ed Mle Education Studies Option, Teaching, Learning, & Foundations

Program Revisions/Additions

No abstract provided.

Health Promotion Honors, Health Promotion

Program Revisions/Additions

No abstract provided.

Human Services Major, Human Services

Program Revisions/Additions

No abstract provided.

Multiomics Modeling Of The Immunome, Transcriptome, Microbiome, Proteome And Metabolome Adaptations During Human Pregnancy, Mohammad Sajjad Ghaemi, Daniel B. Digiulio, Kévin Contrepois, Benjamin Callahan, Thuy T.M. Ngo, Brittany Lee-Mcmullen, Benoit Lehallier, Anna Robaczewska, David Mcilwain, Yael Rosenberg-Hasson, Ronald J. Wong, Cecele Quaintance, Anthony Culos, Natalie Stanley, Athena Tanada, Amy Tsai, Dyani Gaudilliere, Edward Ganio, Xiaoyuan Han, Kazuo Ando, Leslie Mcneil, Martha Tingle, Paul Wise, Ivana Maric, Marina Sirota, Tony Wyss-Coray, Virginia D. Winn, Maurice L. Druzin, Ronald S. Gibbs

All Dugoni School of Dentistry Faculty Articles

Motivation Multiple biological clocks govern a healthy pregnancy. These biological mechanisms produce immunologic, metabolomic, proteomic, genomic and microbiomic adaptations during the course of pregnancy. Modeling the chronology of these adaptations during full-term pregnancy provides the frameworks for future studies examining deviations implicated in pregnancy-related pathologies including preterm birth and preeclampsia. Results We performed a multiomics analysis of 51 samples from 17 pregnant women, delivering at term. The datasets included measurements from the immunome, transcriptome, microbiome, proteome and metabolome of samples obtained simultaneously from the same patients. Multivariate predictive modeling using the Elastic Net (EN) algorithm was used to measure the …

Differential Dynamics Of The Maternal Immune System In Healthy Pregnancy And Preeclampsia, Xiaoyuan Han, Mohammad Sajjad Ghaemi, Kazuo Ando, Laura S. Peterson, Edward A. Ganio, Amy S. Tsai, Dyani K. Gaudilliere, Ina A. Stelzer, Jakob Einhaus, Basile Bertrand, Natalie Stanley, Anthony Culos, Athena Tanada, Julien Hedou, Eileen S. Tsai, Ramin Fallahzadeh, Ronald J. Wong, Amy E. Judy, Virginia D. Winn, Maurice L. Druzin, Yair J. Blumenfeld, Mark A. Hlatky, Cecele C. Quaintance, Ronald S. Gibbs, Brendan Carvalho, Gary M. Shaw, David K. Stevenson, Martin S. Angst, Nima Aghaeepour

All Dugoni School of Dentistry Faculty Articles

Preeclampsia is one of the most severe pregnancy complications and a leading cause of maternal death. However, early diagnosis of preeclampsia remains a clinical challenge. Alterations in the normal immune adaptations necessary for the maintenance of a healthy pregnancy are central features of preeclampsia. However, prior analyses primarily focused on the static assessment of select immune cell subsets have provided limited information for the prediction of preeclampsia. Here, we used a high-dimensional mass cytometry immunoassay to characterize the dynamic changes of over 370 immune cell features (including cell distribution and functional responses) in maternal blood during healthy and preeclamptic pregnancies. …

Due Process And The Myth Of Sovereignty, Michael Vitiello

McGeorge School of Law Scholarly Articles

No abstract provided.

Developmental Expression Of Monocarboxylate Transporter 1 And 4 In Rat Liver, Michael Ng, Justin Louie, Jieyun Cao, Melanie A. Felmlee

School of Pharmacy Faculty Articles

PURPOSE: Monocarboxylate transporters (MCT) are proton-coupled integral membrane proteins that control the influx and efflux of endogenous monocarboxylates such as lactate, acetate and pyruvate. They also transport and mediate the clearance of drugs such as valproate and gamma-hydroxybutyrate. CD147 functions as ancillary protein that chaperones MCT1 and MCT4 to the cell membrane. There is limited data on the maturation of MCT and CD147 expression in tissues related to drug distribution and clearance. The objective of the present study was to quantify hepatic MCT1, MCT4, and CD147 mRNA, whole cell and membrane protein expression from birth to sexual maturity.

METHODS: Liver …

Hiv Viral Rebound Due To A Possible Drug-Drug Interaction Between Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide And Calcium-Containing Products: Report Of 2 Cases, S. Lena Kang-Birken, Dena El-Sayed, John Prichard

School of Pharmacy Faculty Articles

Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (E/C/F/TAF) is a potent fixed-dose, once-daily regimen for HIV-1 treatment and has rare emergence of drug resistance. We report a potential drug-drug interaction in 2 female patients both receiving treatment for HIV and cerebral toxoplasmosis: one case between E/C/F/TAF with calcium carbonate and a second case involving leucovorin as calcium salt. Both cases resulted in rise in HIV RNA levels and emergence of M184 V mutation and resistance to elvitegravir and raltegravir. To the best of our knowledge, these 2 cases are the first reports of rapid emergence of mutation from coadministration of E/C/F/TAF and calcium.

Responsible, Safe, And Effective Use Of Biologics In The Management Of Low Back Pain: American Society Of Interventional Pain Physicians (Asipp) Guidelines, Annu Navani, Laxmaiah Manchikanti, Sheri L. Albers, Richard E. Latchaw, Jaya Sanapati, Alan David Kaye, Sairam Atluri, Sheldon Jordan, Ashim Gupta, David Cedeno, Alejandro Vallejo, Bert Fellows, Nebojsa Nick Knezevic, Miguel Pappolla, Sudhir Diwan, Andrea M. Trescot, Amol Soin, Adam M. Kaye, Steve M. Aydin, Aaron K. Calodney, Kenneth D. Candido, Sanjay Bakshi, Ramsin M. Benyamin, Ricardo Vallejo, Art Watanabe, Douglas Beall, Todd P. Stitik, Patrick M. Foye, Erik M. Helander, Joshua A. Hirsch

School of Pharmacy Faculty Articles

BACKGROUND: Regenerative medicine is a medical subspecialty that seeks to recruit and enhance the body's own inherent healing armamentarium in the treatment of patient pathology. This therapy's intention is to assist in the repair, and to potentially replace or restore damaged tissue through the use of autologous or allogenic biologics. This field is rising like a Phoenix from the ashes of underperforming conventional therapy midst the hopes and high expectations of patients and medical personnel alike. But, because this is a relatively new area of medicine that has yet to substantiate its outcomes, care must be taken in its public …

Mechanisms Underlying Neuroprotection By The Nsaid Mefenamic Acid In An Experimental Model Of Stroke, Parto S. Khansari, Robert F. Halliwell

School of Pharmacy Faculty Articles

Stroke is a devastating neurological event with limited treatment opportunities. Recent advances in understanding the underlying pathogenesis of cerebral ischemia support the involvement of multiple biochemical pathways in the development of the ischemic damage. Fenamates are classical non-steroidal anti-inflammatory drugs but they are also highly subunit-selective modulators of GABAA receptors, activators of IKS potassium channels and antagonists of non-selective cation channels and the NLRP3 inflammosome. In the present study we investigated the effect of mefenamic acid (MFA) in a rodent model of ischemic stroke and then addressed the underlying pharmacological mechanisms in vitro for its actions in vivo. The efficacy …

The Sight And Site Of North Korea: Citizen Cartography's Rhetoric Of Resolution In The Satellite Imagery Of Labor Camps, Timothy Barney

Rhetoric and Communication Studies Faculty Publications

In recent years, satellite mapping of North Korea, especially of its labor camps, has become important forms of evidence of human rights violations, used by transnational advocacy groups to lobby to Western governments for change. A phenomenon of “citizen cartography” has emerged where non-expert humanitarian actors use commercially available software like Google Earth to “infiltrate” the borders of North Korea. This essay interrogates the politics of seeing that takes place in creating the site and sight of North Korea by citizen cartographers, and historicizes these processes of seeing in Cold War and post-Cold War visual culture. Specifically, citizen cartography of …

Raman Spectroscopy Of Blood Plasma Samples From Breast Cancer Patients At Different Stages., H. F. Nargis, H. Nawaz, A. Ditta, T. Mahmood, N. Rashid, M. Muddassar, M. I. Majeed, H. N. Bhatti, M. Saleem, K. Jilani, Franck Bonnier, Hugh Byrne

Articles

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.

Kinder And Less Just: A Critical Analysis Of Modern Gleaning Organizations And Their Place In Food Recovery Discourse, Anna Clare Gorman

University of the Pacific Theses and Dissertations

The practice of gleaning began as a way for the poor to provide sustenance for themselves and their families. Changes in societal ideas about private property as well as a shift toward a neoliberal style of governance have caused gleaning to become what it is today: a practice primarily undertaken by charitable organizations, nonprofits, and church groups who then donate their bounty to local food banks, providing fresh produce to the food insecure. In modern society, gleaning is often held up as a single solution to the problems of food insecurity, poor nutrition, and food waste. This thesis complicates that …

Strategies To Identify And Reduce Workplace Bullying To Increase Productivity, Dr. Marvalene King

Walden Dissertations and Doctoral Studies

Workplace bullying caused business owners to lose about 80 million employees' workdays each year. Workplace bullying can cost an organization up to $300 billion for increased medical claims, lost productivity, and employee turnovers, and up to $23 billion in additional expenses, such as costs for employee absenteeism and legal costs. The purpose of this single case study was to explore successful strategies to address workplace bullying used by 7 human resource (HR) managers and executives in 1, small-to-medium-sized organization in Central Florida. The HR managers and executives had 5 or more years of HR experience. The risk management framework and …

School Personnel Perspectives On Supporting Teachers Of Students With Social-Emotional And Academic Needs, Ana Elisa Lee

Walden Dissertations and Doctoral Studies

Thirty percent of elementary schools that serve underprivileged students in a Texas school district are considered low-performing according to state standards in the 2016 2017 school year. Little is known about the perspectives on the support teachers need while teaching students with high social-emotional and academic needs. The purpose of this general qualitative study was to examine perspectives on principal support for teachers who teach these populations. Data were collected through interviewing 9 teachers, 3 principals, 3 counselors, 3 instructional coaches, and 1 district academic leader. Social cognitive theory, role theory, and cognitive evaluation theory constituted the conceptual framework. Individual …

Modified Eye Movement Desensitization Therapy Protocol Treating Substance Abuse Disorders, Elise Von Tersch

Walden Dissertations and Doctoral Studies

Quality substance abuse treatment is needed to help fight the battle against drug addiction. This qualitative study was designed to explore some of the approaches to eye movement desensitization (EMDR) therapy that therapists trained in Parnell's adapted EMDR model use in conjunction with treatment for addictions. The purpose of this narrative inquiry was to investigate the experience of therapists who incorporate substance abuse treatment with Parnell's adapted EMDR model when treating trauma and substance use disorders. The population studied comprised licensed mental health therapists who had completed Parnell's EMDR training and implemented Parnell's modified EMDR protocol in their professional practice. …

Informal Caregivers' Lived Experiences Caring For A Black Man Receiving Hemodialysis, Tanikka Joy Greene

Walden Dissertations and Doctoral Studies

Numerous quantitative studies have assessed caregiver burden in multiple chronic diseases, but an identified gap and underrepresentation exists in the literature regarding studies using an inductive approach that allow informal caregivers to describe the lived experiences of caring for Black men receiving hemodialysis. The transactional model of stress and coping and the stress process model guided this study. The key research questions centered on the experiences, psychological, physical, and financial limitations associated with caregiving. This phenomenological study used a purposive sample of 15 unpaid primary caregivers over the age of 18 caring for a Black male on hemodialysis from Mecklenburg …

A Clinical Practice Guideline To Improve Education In The Heart Failure Population, Mailey L. Wilks

Walden Dissertations and Doctoral Studies

Managing heart failure patients in the outpatient setting can pose a challenge for nurses and health care staff due to the need to educate patients on self-care skills and management of disease. Several factors, including health literacy and numeracy, need to be considered when developing an education program for heart failure patients to promote self-care management. The purpose of this project was to provide nursing staff with a clinical practice guideline (CPG) that incorporated health and numeracy literacy assessment into an individualized education program. The Johns Hopkins nursing evidence-based practice (EBP) model, the situation-specific theory of heart failure (HF) self-care, …

Fall Of The American Dressmaker 1880-1920, Angela L. Cramer-Reichelderfer

Browse all Theses and Dissertations

During America’s Progressive Era, the dressmaking and millinery trades offered women unique employment and entrepreneurial opportunities and a real alternative to both middle-class domesticity and the working-class wage. As women became more socially visible through their pursuits in education, employment, and sport, their clothing and headwear began to reflect their active lifestyles. Consequently, women’s journey toward female emancipation post-Civil War set in motion the dramatic decline of the very trades – dressmaking and millinery – which gave the women who worked them social influence, professional respect, and economic independence. For this project, I created a public exhibit in which I …

Aerodynamics Of Fan Blade Blending, Clint J. Knape

Browse all Theses and Dissertations

Blending is a method of fan and compressor blade repair. The goal of the blending process is to remove stress concentration points such as cracks and nicks along the leading, trailing, or tip edges of the blade. The stressed areas are typically removed by grinding or cropping away the surrounding material. For integrally bladed rotor (IBR) disks, repairing a damaged blade is much more economical than replacing the entire disk. However, the change in shape of the blade will change the local aerodynamics and result in mistuning, both structurally and aerodynamically. In a worst case scenario, the change in the …

The Use Of Force: Hard Offensive Counterterrorism, Daniel Thomas

Browse all Theses and Dissertations

In the following research, I investigate whether hard offensive counterterrorism results in the failure or success of a counterterrorism strategy. In the second chapter, the academic literature of counterterrorism strategies is examined. Next, a hypothesis is put forth that if a hard offensive counterterrorism strategy is utilized, indicators such as high troop levels, more civilian casualties, more negative public opinion, and an increased rate of terrorism, will point to a failed counterterrorism strategy. Then, I put forth a methodology to test the hypothesis while introducing troop level databases, various public opinion polling sources, and terrorist attack databases to investigate the …