Digital Commons Network^™

Fracture Repair Requires Trka Signaling By Skeletal Sensory Nerves., Zhu Li, Carolyn A Meyers, Leslie Chang, Seungyong Lee, Zhi Li, Ryan Tomlinson, Ahmet Hoke, Thomas L Clemens, Aaron W James

Department of Orthopaedic Surgery Faculty Papers

Bone is richly innervated by nerve growth factor-responsive (NGF-responsive) tropomyosin receptor kinase A-expressing (TrKa-expressing) sensory nerve fibers, which are required for osteochondral progenitor expansion during mammalian skeletal development. Aside from pain sensation, little is known regarding the role of sensory innervation in bone repair. Here, we characterized the reinnervation of tissue following experimental ulnar stress fracture and assessed the impact of loss of TrkA signaling in this process. Sequential histological data obtained in reporter mice subjected to fracture demonstrated a marked upregulation of NGF expression in periosteal stromal progenitors and fracture-associated macrophages. Sprouting and arborization of CGRP+TrkA+ sensory nerve fibers …

American Black Bears (Ursus Americanus) Of The Paunsaugunt Plateau: Movements And Habitat Use, Rebekah Adriana Castro Dungan

Theses and Dissertations

Concerns over human-bear conflict and questions about the ecology of Paunsaugunt Plateau's population of black bears (Ursus americanus) arose due to their visitation to popular recreation sites. Greater insight about bears and their habitat use provides a foundation for conflict mitigation and effective management decisions. Between 2014 and 2017, seventeen black bears (11 female, 6 male) were fitted with global positioning system (GPS) radio-collars so that we could track their locations, daily activity patterns, and ambient temperatures. By analyzing bear locations, we calculated annual and seasonal home ranges for 16 bears, including 25 den sites. Home ranges typically consisted of …

The Bg News December 02, 2019, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. December 02, 2019. Volume 99-Issue 18.

Children’S Gender And Investments From Nonresident Fathers, Kristin Mammen

Publications and Research

Evidence suggests that fathers have stronger ties to sons than daughters, which may result in differential investments in their children. This paper investigated whether girls’ gender restricts their access to fathers' contributions if they do not live together. The data used were the 1994-2008 March/April Match Current Population Survey Child Support Supplements, a large, nationally representative sample which identifies child support eligible mothers of all marital statuses and collects information on nonresident fathers’ financial and social investments in their children. Results for court-mediated outcomes such as the existence and amounts of child support orders showed that courts do not allocate …

Differential Qualitative Analysis: A Pragmatic Qualitative Methodology To Support Personalised Healthcare Research In Heterogenous Samples, Freda N. Gonot-Schoupinsky, Gulcan Garip

The Qualitative Report

Differential qualitative analysis (DQA) was developed as a pragmatic qualitative health methodology for the exploration of individual differences, behaviours, and needs within heterogeneous samples. Existing qualitative methodologies tend to emphasise the identification of general principles, an approach that can lead to standardised treatment, care, and medicine. DQA emphasises the identification of individual variation, in order to inform personalised healthcare. DQA comprises an accessible three-stage approach: first individual profiles are explored and differentiated into research-relevant subgroups; then each subgroup is analysed, and findings identified; finally, the data is analysed in its entirety and overall and subgroup findings are presented. DQA was …

Curtis Rudolph Battle

African American Funeral Programs

No abstract provided.

Scientometric Mapping And Visualization Of Environmental Science Research: A Case Study, Sanku Bilas Roy

Library Philosophy and Practice (e-journal)

The present study attempts to emphasize quantitatively the development of environmental science literature in terms of publication output as per Scopus database for thirty years (1989-2018). The focus of this paper is to analysis the literature published by the researchers of the University of Calcutta during the period under study. Total 1093 records have been retrieved for this study. An exponential growth rate has been identified. Authorship trend was towards multi-authored papers. Most prolific authors and most productive journals have been traced. The most productive journal is Environmental Monitoring and Assessment. Co-authorship pattern and Co-occurrence of keywords have also been …

Sustainability Assessment Of Wireless Community Grid For Off-Grid Communities: A Case Study For Haiti, Tejan Adhikari

Theses

Affordable, reliable, and sustainable energy service is fundamental to human, social and economic development. Approximately 1.2 billion people lack access to basic energy services. There exists a huge energy access gap between urban centers and rural areas. Approximately 84% of the people deprived of energy access live in rural areas. Existing rural electrification options including grid extension, mini-grids, and stand-alone solar home systems, have limited penetration in rural regions. Entrepreneurs, with support from governments and international institutions, have experimented with different business mechanisms to facilitate energy delivery. A significant amount of investment is being made for rural electrification but many …

New Possibilities For Stilt Building, Zhuming Liu

Theses

The purpose of the thesis lies in exploring the new possibilities of the stilt building in dealing with two sustainability problems caused by urban development: the Lack of Public Greening in Prosperous, High-density Areas, and the Continuous Sprawl of Private Housing in Suburbs.

As a functional building method with a long history, stilt building, or known as building with “The Pilotis,” regained its vitality in the 20th century with Le Corbusier. However, the common application mode of today’s stilt building has deviated from Corbusier's original intention, which was to provide sheltered outdoor green space for residents in the city. This …

State V. Galvan Respondent's Brief Dckt. 47017

Not Reported

No abstract provided.

Sense Of Belonging And Racial Diversity At The U.S. Service Academies, Leah Pound

Doctoral Dissertations

On college campuses, access does not equal inclusion as students of color have to navigate through a predominately White space as they struggle to feel like they belong (Jack, 2019). This dissertation focuses on racial experiences and belonging within a total institution (Goffman, 1961): the U.S. service academies, colleges that are part university and part military. Across three separate papers, I explore the institutional factors that impact the disparity between Black and White students’ belonging. In Chapter 1, I apply Allport’s contact theory (1954) alongside the concept of relative deprivation (Stouffer, 1949) to systematically compare the experiences of Black and …

Application Of Machine Learning To Enhance The Diagnostic Utility Of Interictal High Frequency Oscillations In Drug-Resistant Epilepsy, Stefan Sumsky

Doctoral Dissertations

There is a need for novel biomarkers to aid in the clinical treatment of epilepsy and improve the understanding of seizure generation and the seizure onset zone (SOZ). High frequency oscillations (HFO) are a promising biomarker with the potential to fill this role, but early efforts to apply them have fallen short of clinical quality tools and validity and application of their association with seizure have not been fully explored. This study will advance the understanding and application of HFO to the clinical setting in three ways. First, the relevance of HFO to SOZ and their utility for SOZ localization …

Exodus/Bay Shore: How An Idea Became A Reality, Freda Elliott Baker

West Islip (New York) Church of Christ Audio Collection

Freda Eliott Baker recounts the story of the ExodusBayshore church plant.

Components Of The Ribosome Biogenesis Pathway Underlie Establishment Of Telomere Length Set Point In Arabidopsis, Liliia R. Abdulkina, Callie Kobayashi, John T. Lovell, Inna B. Chastukkhina, Behailu B. Aklilu, Inna A, Agabekian, Ana V. Suescún, Lia R. Valeeva, Chuluuntsetseg Nyamsuren, Galina V. Aglyamova, Margarita R. Sharipova, Dorothy E. Shippen, Thomas E. Juenger, Eugene V. Shakirov

Biological Sciences Faculty Research

Telomeres cap the physical ends of eukaryotic chromosomes to ensure complete DNA replication and genome stability. Heritable natural variation in telomere length exists in yeast, mice, plants and humans at birth; however, major effect loci underlying such polymorphism remain elusive. Here, we employ quantitative trait locus (QTL) mapping and transgenic manipulations to identify genes controlling telomere length set point in a multi-parent Arabidopsis thaliana mapping population. We detect several QTL explaining 63.7% of the total telomere length variation in the Arabidopsis MAGIC population. Loss-of-function mutants of the NOP2A candidate gene located inside the largest effect QTL and of two other …

I Sh*T You Not, Jordan Dollar

Graduate Scholarly Works

"I Sh*t You Not" is an exercise in "edutainment" intended to instill feelings of skepticism and curiosity in its players when confronted with attention-grabbing headlines. Developed as an amusing answer to the fake news epidemic, this game can be played with up to four players in a head-to-head assessment of each other's evaluation skills.

Collaboration Patterns As A Function Of Research Experience Among Mixed Researchers: A Mixed Methods Bibliometric Study, Melanie S. Wachsmann, Anthony J. Onwuegbuzie, Susan Hoisington, Vanessa Gonzales, Rachael Wilcox, Rachel Valle, Majed Aleisa

The Qualitative Report

Onwuegbuzie et al. (2018) documented that the degree of collaboration is higher for mixed researchers than for qualitative and quantitative researchers. The present investigation examined the (a) link between the research experience of lead authors and their propensity to collaborate (Quantitative Phase), and (b) role of research experience in collaborative mixed research studies (Qualitative Phase). Analyses of articles published in the Journal of Mixed Methods Research from 2007 (its inception) to the third issue in 2018 (time of data collection) revealed that the average research experience of lead authors decreased from 20.29 in 2007 to 14.24 in 2017 (last complete …

Differences In Guided Imagery Between High And Low Self-Critical Participants: Consensual Qualitative Research Analysis, Julia Halamova, Jana Koroniova, Martina Baránková

The Qualitative Report

As self-criticism is considered to be the major underlying factor of all sorts of psychopathology, it is meaningful to explore the differences between how people deal with their self-criticism based on their level of self-criticism. The aim of this study was to categorise descriptions and investigate differences between 5 high and 5 low self-critical participants in their self-critical, self-protective and self-compassionate imageries. The total sample consisted of 10 university students, who were selected from a larger sample of 88 participants based on their extreme score from The Forms of Self-Criticising/Attacking and Self-Reassuring Scale. For analysis, we exploited Consensual Qualitative Research …

Sik3 Suppresses Neuronal Hyperexcitability By Regulating The Glial Capacity To Buffer K+ And Water, Hailun Li, Alexandra Russo, Aaron Diantonio

Open Access Publications

Glial regulation of extracellular potassium (K

Disease-Associated Mutations In Niemann-Pick Type C1 Alter Er Calcium Signaling And Neuronal Plasticity, Scott A. Tiscione, Oscar Vivas, Kenneth S. Ginsburg, Donald M. Bers, Daniel S. Ory, Luis F. Santana, Rose E. Dixon, Eamonn J. Dickson

Open Access Publications

Niemann-Pick type C1 (NPC1) protein is essential for the transport of externally derived cholesterol from lysosomes to other organelles. Deficiency of NPC1 underlies the progressive NPC1 neurodegenerative disorder. Currently, there are no curative therapies for this fatal disease. Given the Ca

Association Of Longitudinal Changes In Cerebrospinal Fluid Total Tau And Phosphorylated Tau 181 And Brain Atrophy With Disease Progression In Patients With Alzheimer Disease, Jorge J. Llibre-Guerra, Yan Li, Suzanne E. Schindler, Brian A. Gordon, Anne M. Fagan, John C. Morris, Tammie L.S. Benzinger, Jason Hassenstab, Sarah B. Berman, David M. Holtzman, Chengjie Xiong, Randall J. Bateman, Eric Mcdade

Open Access Publications

Importance: The amyloid/tau/neurodegeneration (A/T/N) framework uses cerebrospinal fluid (CSF) levels of total tau (tTau) as a marker of neurodegeneration and CSF levels of phosphorylated tau 181 (pTau181) as a marker of tau tangles. However, it is unclear whether CSF levels of tTau and pTau181 have similar or different trajectories over the course of Alzheimer disease.

Objectives: To examine the rates of change in CSF levels of tTau and pTau181 across the Alzheimer disease course and how the rates of change are associated with brain atrophy as measured by magnetic resonance imaging.

Design, Setting, and Participants: This cohort study was set …

Single-Nucleotide Polymorphism-Based Genetic Risk Score And Patient Age At Prostate Cancer Diagnosis, Rong Na, Craig Labbate, Hongjie Yu, Zhuqing Shi, Richard J. Fantus, Chi-Hsiung Wang, Gerald L. Andriole, William B. Isaacs, S Lilly Zheng, Brian T. Helfand, Jianfeng Xu

Open Access Publications

Importance: Few studies have evaluated the association between a single-nucleotide polymorphism-based genetic risk score (GRS) and patient age at prostate cancer (PCa) diagnosis.

Objectives: To test the association between a GRS and patient age at PCa diagnosis and to compare the performance of a GRS with that of family history (FH) in PCa risk stratification.

Design, Setting, and Participants: A cohort study of 3225 white men was conducted as a secondary analysis of the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) chemoprevention trial, a 4-year, randomized, double-blind, placebo-controlled multicenter study conducted from March 2003 to April 2009 to evaluate …

Three Essays On Fisheries Economics, David T. Suh

Doctoral Dissertations

Archival abstract submitted

Mmu: 12/02/19–12/08/19, Student Bar Association

Monday Morning Update

This Week @ NDLS

• Christmas Tree Decorating
• Daily Commons Menu Specials
• SBA Store Hours
• Daily Mass Schedule
• ND Glee Club Caroling
• Championship Week--PAC12, SEC, Big 10, Big 12, and ACC
• Next Week: Dog Dayz of Finals

General Announcements

• LVCY Angel Tree
• Health & Wellness Center
• Legal Writing Center
• Volunteer Opportunity at Green Bridge Growers
• Notice to student visitors to Sinai Synagogue
• Mock Trial Coaches Wanted
• Advertise Law School Events on the Law Library e-board

A Little Lagniappe (In Louisiana it means "a little something extra".)

• Marge's Message
• Sport Report
• Professor Spotlight–no one this week
• 1L of the Week–study hard and …

Allele-Specific Rna Interference Prevents Neuropathy In Charcot-Marie-Tooth Disease Type 2d Mouse Models., Kathryn H Morelli, Laurie B Griffin, Nettie K Pyne, Lindsay M Wallace, Allison M Fowler, Stephanie N Oprescu, Ryuichi Takase, Na Wei, Rebecca Meyer-Schuman, Dattatreya Mellacheruvu, Jacob O Kitzman, Samuel G Kocen, Timothy J Hines, Emily L Spaulding, James R Lupski, Alexey Nesvizhskii, Pedro Mancias, Ian J Butler, Xiang-Lei Yang, Ya-Ming Hou, Anthony Antonellis, Scott Q Harper, Robert W Burgess

Department of Biochemistry and Molecular Biology Faculty Papers

Gene therapy approaches are being deployed to treat recessive genetic disorders by restoring the expression of mutated genes. However, the feasibility of these approaches for dominantly inherited diseases - where treatment may require reduction in the expression of a toxic mutant protein resulting from a gain-of-function allele - is unclear. Here we show the efficacy of allele-specific RNAi as a potential therapy for Charcot-Marie-Tooth disease type 2D (CMT2D), caused by dominant mutations in glycyl-tRNA synthetase (GARS). A de novo mutation in GARS was identified in a patient with a severe peripheral neuropathy, and a mouse model precisely recreating the mutation …

The Eastern Echo, December 2, 2019, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Lanthorn, Vol. 54, No. 17, December 2, 2019, Grand Valley State University

Volume 54, July 15, 2019 - April 27, 2020

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Situational Awareness: Examining Factors That Affect Cyber-Risks In The Maritime Sector, K Tam, Kd Jones

School of Engineering, Computing and Mathematics

Standard risk assessments are used to define and prioritize threats within a sector. However, the rising number of cybersecurity risks in maritime are often temperamental to a range of environmental, technical, and social factors. A change during an incident can significantly alter the risks and, consequently, the incident outcomes. Therefore, agile, changing risk profiles are becoming more necessary in the modern world. In addition to static and dynamic, maritime operational risks can be affected by cyber, cyber-physical, or physical elements. This demonstrates the equal use of information and operational technology (IT/OT); however, most quantitative risk assessment frameworks focus on one …

The Study Of Zeolitic Imidazolate Framework (Zif-8) Doped Polyvinyl Alcohol/Starch/Methyl Cellulose Blend Film, Shaoxiang Lee, Yunna Lei, D Wang, Chunxu Li, Jiaji Cheng, J Wang, Wenqiao Meng, Meng Liu

School of Engineering, Computing and Mathematics

ZIF-8 nanoparticle-doped polyvinyl alcohol (PVA)-S-MC films were prepared via casting method. The effect of different concentrations of ZIF-8 on the physical properties and structural characterization of the films were investigated. The results indicated that ZIF-8 could increase the water resistance and mechanical property of the membrane. Through FTIR, scanning electron microscope (SEM), atomic force microscope (AFM), and TGA analysis, it was found that ZIF-8 changed the phenomenon of macromolecule agglomeration and improved the thermal stability of the membrane. The breathable behavior of the film was also studied through oxygen permeability and water vapor permeability analysis. The result illustrated that the …

Identifying Undetected Dementia In Uk Primary Care Patients: A Retrospective Case-Control Study Comparing Machine-Learning And Standard Epidemiological Approaches, E Ford, P Rooney, S Oliver, R Hoile, Et Al

Peninsula Medical School

Background: Identifying dementia early in time, using real world data, is a public health challenge. As only two-thirds of people with dementia now ultimately receive a formal diagnosis in United Kingdom health systems and many receive it late in the disease process, there is ample room for improvement. The policy of the UK government and National Health Service (NHS) is to increase rates of timely dementia diagnosis. We used data from general practice (GP) patient records to create a machine-learning model to identify patients who have or who are developing dementia, but are currently undetected as having the condition by …

Decision In Art. 78 Proceeding - Clark, Ronald (2018-01-24)

Decisions in Art. 78 Proceedings

No abstract provided.