Digital Commons Network^™

Glycine Supplementation Extends Lifespan Of Male And Female Mice, Richard A. Miller, David E. Harrison, C. Michael Astle, Molly A. Bogue, Joel Brind, Elizabeth Fernandez, Kevin Flurkey, Martin Javors, Warren Ladiges, Christiaan Leeuwenburgh, Francesca Macchiarini, James Nelson, Alexey G. Ryazanov, Jessica Snyder, Timothy M. Stearns, Douglas E. Vaughan, Randy Strong

Publications and Research

Diets low in methionine extend lifespan of rodents, though through unknown mechanisms. Glycine can mitigate methionine toxicity, and a small prior study has suggested that supplemental glycine could extend lifespan of Fischer 344 rats. We therefore evaluated the effects of an 8% glycine diet on lifespan and pathology of genetically heterogeneous mice in the context of the Interventions Testing Program. Elevated glycine led to a small (4%–6%) but statistically significant lifespan increase, as well as an increase in maximum lifespan, in both males (p = 0.002) and females (p < 0.001). Pooling across sex, glycine increased lifespan at each of the three independent sites, with significance at p = 0.01, 0.053, and 0.03, respectively. Glycinesupplemented females were lighter than controls, but there was no effect on weight in males. End‐of‐life necropsies suggested that glycine‐treated mice were less likely than controls to die of pulmonary adenocarcinoma (p = 0.03). Of the 40 varieties of incidental pathology evaluated in these mice, none were increased to a significant degree by the glycine‐supplemented diet. In parallel analyses of the same cohort, we found no benefits from TM5441 (an inhibitor of PAI‐1, the primary inhibitor of tissue and urokinase plasminogen activators), inulin (a source of soluble fiber), or aspirin at either of two doses. Our glycine results strengthen the idea that modulation of dietary amino acid levels can increase healthy lifespan in mice, and provide a foundation for further investigation of dietary effects on aging and late‐life diseases.

Health Care Providers: Please Listen, Jasmin Tahmaseb-Mcconatha

Psychology Faculty Publications

Remind providers that you can contribute to your health care decisions.

On The Geographies Of Hair: Exploring The Entangled Margins Of The Bordered Body, Mark Holton

School of Geography, Earth and Environmental Sciences

No abstract provided.

The Attitude Of Medical Practices Toward Lgbt Older Adults Before And After Intervention, Mackenzi Kim Ms4, Lynn M. Wilson Do, Nyann Biery Ms, Brenda Frutos Mph, Ches

USF-LVHN SELECT

No abstract provided.

The Impact Of Superfast Broadband, Tailored Booklets For Households, And Discussions With General Practitioners On Personal Electronic Health Readiness: Cluster Factorial Quasi-Randomized Control Trial., Philip Abbott-Garner, Janet Richardson, Ray B. Jones

School of Nursing and Midwifery

BACKGROUND: Electronic health (eHealth) may improve health outcomes, but many people remain digitally excluded. Personal readiness to use the internet for health may be limited by lack of internet infrastructure, personal skills, social support, service provision, and cost. The impact of interventions to reduce these barriers is unknown. From 2011, the British Government supported the implementation of "superfast" broadband (Superfast) across the rural county of Cornwall. This provided the opportunity to assess the impact of interventions at regional, practice, and household levels. OBJECTIVE: This study aimed to assess the impact of 3 interventions on personal eHealth readiness: (1) regional-level implementation …

Exploring Older Adults' Perceptions Of The Utility And Ease Of The Use Of Personal Emergency Response Systems, Patrica Ann Mclean

Dissertations

The aim of this study was to explore and describe perceptions of the utility and ease of use of a personal emergency response system (PERS) among older adults who are aging in place. Research Question: "What is the meaning of a PERS use for functionally impaired older adults?"

The Weekly Challenger, March 7, 2019, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The March 7, 2019, issue of The Weekly Challenger.

Family Conversation Kit, Yingyi Mo

Theses

Deep, bidirectional family conversations are where family members express, listen to and understand each other’s inner thoughts with an open mindset. Such conversations can strengthen the comprehension and connection among family members, pass down cultural and family heritage further, and improve the cohesion and well-being of families and society. However, deep, bidirectional conversations are often neglected, especially in Chinese culture.

Such a lack is indiscernible to many people because they have been so used to hiding inner thoughts from their families that they find nothing wrong with it. Some are aware of the shortage, while the embarrassment comes right after …

Undergraduate Nursing Students Knowledge Of Aging, Attitudes Toward And Perceptions Of Working With Older Adults In Kathmandu Nepal, Saruna Ghimire, Nitisha Shrestha, Karen E. Callahan, Dhirendra Nath, Binaya Kumar Baral, Nirmala Lekhak, Devendra Raj Singh

Nursing Faculty Research

Objectives:This study aims to examine Nepalese undergraduate nursing students’knowledge of aging,attitudes towards older adults and perceptions of working with older adults, and to assess differences inthese outcomes by socio-demographic characteristics as well as type of nursing program.Methods:A cross-sectional study was conducted among 385 undergraduate nursing students in sixnursing colleges located in the Kathmandu Valley. Knowledge of aging, attitudes toward older adults andperceptions of working with older adults were assessed using standardized tools, the Palmore Facts onAging Quiz, Kogan's Attitudes towards Older People Scale, and Nolan's Intent to Work with Older PeopleQuestionnaire, respectively.Results:The mean knowledge scores on older adults and aging …

College Voice Vol. 42 No. 9 [March 5, 2019], Connecticut College

2018-2019

No abstract provided.

Effect Of Dual-Task Walking On Long-Range Correlations In People With Parkinson's Disease, Shane Meltz

UNO Student Research and Creative Activity Fair

Parkinson’s Disease (PD) causes gait to be more variable and more random. Gait variability is related to disease severity, and may be a marker of fall risks. Gait in PD is attention-dependent, meaning a distraction while walking could be detrimental. The effects of dual-task walking on gait variability in PD are unclear (in particular fractal fluctuations). This study will determine if dual-task walking impacts stride-to-stride variability compared to normal walking in people with Parkinson’s Disease. We predict that dual-tasking will lead to more random stride-to-stride variability in people with PD, compared to controls. Also, within the PD group, we predict …

Depressive Symptoms, Social Activity, And Physical Activity In Older Adults, Hyeon Jung (Judith) Kim

UNO Student Research and Creative Activity Fair

Depressive symptoms are negatively related to mental health and quality of life. Social and physical activities have been used as indicators of depressive symptoms in older populations. Participation in high levels of social and physical activities has been associated with decreased depressive symptoms. This pilot study explored the relationship between the levels of social and physical activities and depressive symptoms among older adults living in an independent living facility. Twenty-two participants (Age M=87.50; SD=7.50; 82% women) were recruited and completed The Geriatric Depression Scale short form, the Revised Change in Activity and Interest Index (assessed social activity level), and Godin …

Pilot Study Of Empathy In Adults, Libby Moberg

UNO Student Research and Creative Activity Fair

Empathy is of critical public health importance due to its association with relationship satisfaction and well-being (Davis & Oathout, 1987; Davis, 1983). There is growing evidence that bilingual individuals may have higher levels of empathy (Javor, 2016). One potential mechanism for this relationship is that bilingual individuals tend to have higher levels of executive functioning (Costa et al, 2008), which is linked to higher empathy because individuals are able to more easily adopt others’ perspectives. Previous studies examining this question have largely relied on self-report questionnaires assessing empathy as a general tendency (i.e., trait). No studies have examined differences in …

Physical Activity And Cognitive Function Among Older Adults With An Elevated Gamma Gap, Emily Frith, Paul D. Loprinzi

Faculty and Student Publications

© 2018 The Author(s) Published by S. Karger AG, Basel. Objective: An elevated gamma gap is indicative of high serum concentrations of globulin proteins, some of which elicit acute inflammatory responses. An impaired cognitive function has been linked to central and peripheral inflammation, while exercise is associated with protective, anti-inflammatory benefits. In this study, we evaluated whether the gamma gap is associated with cognitive function among older adults and whether physical activity is favorably associated with cognitive function among those with an elevated gamma gap. Materials and Methods: Data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES) were …

The Effects Of Tai Chi On Markers Of Atherosclerosis, Lower-Limb Physical Function, And Cognitive Ability In Adults Aged Over 60: A Randomized Controlled Trial, Shengwen Zhou, Yanjie Zhang, Zhaowei Kong, Paul D. Loprinzi, Yang Hu, Jiajie Ye, Shijie Liu, Jane Jie Yu, Liye Zou

Faculty and Student Publications

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. Objective: The purpose of this study was to investigate the effects of Tai Chi (TC) on arterial stiffness, physical function of lower-limb, and cognitive ability in adults aged over 60. Methods: This study was a prospective and randomized 12-week intervention trial with three repeated measurements (baseline, 6, and 12 weeks). Sixty healthy adults who met the inclusion criteria were randomly allocated into three training conditions (TC-24, TC-42, and TC-56) matched by gender, with 20 participants (10 males, 10 females) in each of the three groups. We measured the following health outcomes, …

Connections 03/2019, College Of Health And Human Services

College of Health and Human Services Newsletter

• Student helps theater launch program for visually impaired patrons
• David Areaux named new chair of Department of Physician Assistant
• Dr. Earlie Washington to receive 5th annual Purple Poppy Award
• OT student to present at national conference
• WMU alum finds success in Broadway's 'Hamilton'
• Miller Broadway lineup includes 'Grinch.' 'Les Miserables'
• Sixth-graders get a look at college life at WMU

The Effects Of A Driving Simulator On Driving-Related Skills Necessary For Adl And Iadl Function, Rebecca Pope, Haley Szpara

Occupational Therapy Graduate Student Evidenced-Based Research Reviews

Background

Returning to driving is often a goal for an individual following a neurological impairment. Critical skills for success in returning to driving include intact cognition, visual, and visual-perceptual skills which are skills that are commonly compromised in individuals who have had a neurological accident. In addition, these skills are necessary for other areas of instrumental activities of daily living (IADLS), as well as activities of daily living road driving performance (Crotty & George, 2009). Emerging evidence has shown the use of driving simulator training as an intervention to increase and the generalizability this may have on ADL function and …

Transcranial Doppler Assessment Of Patients With Cerebral Small Vessel Disease, Alaa Ebrahim Ata Ata Shaaban, Mahmoud H. Ebrahim, Mohamed M. T. Elbaghdady, Salma H. M. Khalil

Journal of Medicine in Scientific Research

Background Cerebral small vessel disease (SVD) refers to any pathology in all vascular structures (small arteries, arterioles, capillaries, venules, and small veins). Transcranial Doppler is a bedside, inexpensive, noninvasive technique that can assess intracerebral circulation in real time and can be used for continuous monitoring. Aim of the work Our study tried to detect the pathogenesis of cerebral SVD, especially the implication of the cerebral large artery disease. Moreover, it assessed the ability of transcranial Doppler in evaluating the severity of cerebral SVD and people who are at risk. Patients with cardioembolic risk were excluded. Patients and methods A cross-sectional …

Escaping Death: Naloxone's Chemical Nature And Potential To Combat The Opioid Epidemic, Abigale Miller

Honors Program: Senior Projects (Public)

Naloxone is a life-saving drug with the ability to reverse an opioid overdose. As the opioid epidemic’s death toll rises, we can turn to Naloxone as a tool to combat the crisis. The epidemic, born of corruption, has a wide reach among the people of the United States, with especially firm grasps on middle-aged people, sufferers of chronic pain, white Americans and those living in the eastern portion of the country. Naloxone’s elegant design saves lives by effectively competing for a position on an opioid biding receptor in the brain to almost instantly end an overdose and restore normal breathing. …

An Altered Spatiotemporal Gait Adjustment During A Virtual Obstacle Crossing Task In Patients With Diabetic Peripheral Neuropathy, Chun-Kai Huang, Vijay Shivaswamy, Pariwat Thaisetthawatkul, Lynn Mack, Nicholas Stergiou, Ka-Chun Siu

Journal Articles

This study investigates spatiotemporal gait adjustments that occur while stepping over virtual obstacles during treadmill walking in people with/without diabetic peripheral neuropathy (DPN). Eleven adults with Type 2 diabetes mellitus, ten DPN, and 11 age-matched healthy adults (HTY) participated in this study. They stepped over forthcoming virtual obstacles during treadmill walking. Outcomes such as success rate, spatiotemporal gait characteristics during obstacle crossing, and correlations between these variables were evaluated. The results partially supported our hypotheses that when comparing with HTY and DM, people with DPN adopted a crossing strategy which decreased obstacle crossing success rate and maximal toe elevation, …

Engaging Older Adults With Parkinson’S Disease In Physical Activity Using Technology: A Feasibility Study, Melinda Hermanns, Barbara K. Haas

Nursing Faculty Publications and Presentations

Parkinson’s disease (PD), a progressive neurodegenerative disorder, presents unique and daily challenges. Living with PD may limit one’s physical activity and negatively affect quality of life (QOL). No studies were identified that utilized online technology to promote health in this population. The purposes of this study were to (a) assess the feasibility of an intervention that requires wearing a physical activity tracker and participating in an online support group, and (b) examine the effect of this intervention on the self-efficacy for physical activity and QOL of older adults with PD. A 12-week longitudinal pretest/posttest design was used to assess physical …

Aging In The Town Of Weston: A Community Needs Assessment, Sue Berger, Caitlin Coyle, Jan Mutchler, Nidya Velasco

Center for Social and Demographic Research on Aging Publications

This report describes research undertaken by the Center for Social & Demographic Research on Aging within the Gerontology Institute at the University of Massachusetts Boston, on behalf of the Weston Council on Aging, to investigate the needs, interests, preferences, and opinions of Weston’s population of residents who are age 55 and older. The contents of this report are meant to inform the Weston Council on Aging, and organizations that work with and on behalf of older residents of Weston, for the purposes of planning and coordination of services, but also to build awareness about issues facing the Town of Weston. …

Health Behaviors And Related Disparities Of Insured Adults With A Health Care Provider In The United States, 2015—2016, M. Courtney Hughes, Tamara A. Baker, Hansol Kim, Elise G. Valdes

Faculty Articles, Papers, and Other Scholarship

Health care providers are in a unique position to address patients' health behaviors and social determinants of health, factors like income and social support that can significantly impact health. There is a need to better understand the risk behaviors of a population that providers may counsel (i.e., those who are insured and have a provider.) Using the 2015 and 2016 CDC's Behavioral Risk Factor Surveillance System, we examine the prevalence of health behaviors and the existence of disparities in health behaviors based on social determinants among American adults. Our sample included noninstitutionalized adults aged 18 to 64 years, in the …

A Systematic Review Of Post-Migration Facilitators And Barriers To Integration Among Muslim Refugees In The United States, Sarah Elizabeth Mähler

Honors Capstones

No abstract provided.

The Odd Log-Logistic Gompertz Lifetime Distribution: Properties And Applications, Morad Alizadeh, Saeid Tahmasebi, Mohammad Reza Kazemi, Hamideh Siyamar Arabi Nejad, Gholamhossein G. Hamedani

Mathematical and Statistical Science Faculty Research and Publications

In this paper, we introduce a new three-parameter generalized version of the Gompertz model called the odd log-logistic Gompertz (OLLGo) distribution. It includes some well-known lifetime distributions such as Gompertz (Go) and odd log-logistic exponential (OLLE) as special sub-models. This new distribution is quite flexible and can be used effectively in modeling survival data and reliability problems. It can have a decreasing, increasing and bathtub-shaped failure rate function depending on its parameters. Some mathematical properties of the new distribution, such as closed-form expressions for the density, cumulative distribution, hazard rate function, the kth order moment, moment generating function and …

Genetic Architecture Of Human Obesity Traits In The Rhesus Macaque, Michael J. Raboin, John Letaw, Asia D. Mitchell, David Toffey, Jessica Mckelvey, Charles T. Roberts Jr, Joanne E. Curran, Amanda Vinson

School of Medicine Publications

Objective: Whereas the metabolic consequences of obesity have been studied extensively in the rhesus macaque, corollary genetic studies of obesity are nonexistent. This study assessed genetic contributions to spontaneous adiposity in this species.

Methods: Phenotypic variation by age class and sex for BMI, waist to height ratio, waist to thigh ratio, and waist circumference was assessed in 583 macaques. Total and sex-specific heritability for all traits was estimated, including waist to thigh ratio adjusted for BMI, as well as genotypic and phenotypic correlations. In addition, functional genetic variation at BDNF, FTO, LEP, LEPR, MC4R, PCSK1, POMC, and SIM1 was assessed …

Unintentional Bathtub Drowning Deaths Among Those Aged 65 Years And Older In Australia, Amy E. Peden, Richard C. Franklin, John H. Pearn M.D., Alison J. Mahony

International Journal of Aquatic Research and Education

When compared with other age groups, fatal drowning rates among seniors have stayed static. This study identifies causal factors in unintentional bathtub drowning deaths among people aged 65 years and over. This study is a 10-year (2003-2012) total population retrospective survey of all unintentional bathtub (baths, spa baths and showers) drowning deaths afflicting people aged 65 years and over. Data were sourced from the Australian National Coronial Information System. Risk factors and circumstantial variables were analysed including sex, age, activity prior to drowning, alcohol, drugs, pre-existing medical conditions, living circumstances, time until found, and performance of cardio-pulmonary resuscitation (CPR). There …

March 7, 2019: Agenda, University Of North Dakota

University Senate Meeting Minutes

Agenda for the March 7, 2019, meeting of the University Senate. 49 pages

Report To Congress: Current State Of Technology-Enabled Collaborative Learning And Capacity Building Models, Office Of Health Policy, Office Of The Assistant Secretary For Planning And Evaluation (Aspe)

Project ECHO Bibliography

No abstract provided.

Tingkat Kemampuan Kelola Emosi Marah Siswa Sma, Ferisa Prasetyaning Utami, Blasius Boli Lasan, Im. Hambali

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Anger management need to be owned by adolescents as individuals. The benefits if teenagers can have the ability to manage good anger emotions are to achieve mental health and be able to resolve social conflicts that result from emotional situations. Management of anger emotions is the ability of individuals to express adaptive responses when faced with situations that cause anger. The research design used for this study is quantitative descriptive to explain the phenomenon or picture of anger emotional management ability in high school students, amounting to 67 people. The results of this study are the level of anger management …