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Uniform Distribution Of Fractional Parts Of Average Of Kth Power Of Prime Divisors, Chitpanu Chairatanagul

Chulalongkorn University Theses and Dissertations (Chula ETD)

In this thesis, we prove that for every positive integer k greater than or equal to two, the sequence of the fractional parts of the arithmetic mean of the kth power of prime divisors of n counted with or without multiplicity, as n runs through all positive integers, is uniformly distributed modulo one.

Path Following And Obstacle Avoidance For Autonomous Vehicle Based On Gnss Localization, Kanin Kiataramgul

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nowadays, many systems, formerly operated by human beings, are now developed to minimize user control effort. One outstanding system that receives close attention is the autonomous driving system. However, several autonomous driving systems that are currently developed utilize expensive sensing devices, e.g., camera and laser scanner. Moreover, these devices cannot be solely employed but a high-performance processing unit is also required. These pricey components result in an expensive system that does not worth to be used in some practical applications. Therefore, this research intends to utilize other low-cost sensing devices so that the final price of the developed system can …

Development Of Polymerase Chain Reaction Enzyme Linked Immunosorbent Assay For Detection Of Human Papillomavirus 16 L1 Gene Methylation, Sasiprapa Liewchalermwong

Chulalongkorn University Theses and Dissertations (Chula ETD)

It has been well known that cervical cancer is caused by persistent infections with the high risk human papillomavirus (HR-HPV) especially HPV16 and 18. However, a minority of HR-HPV infected women developed cancer, therefore, triage test is necessary to particularly select some HR-HPV infected women who are at higher risk to progress to cervical cancer quickly for colposcopy examination. Since HPV16 L1 gene hypermethylation has been reported to be correlated well with high grade cervical lesions and cancer, the present study aims to develop PCR-ELISA for detection of HPV16 L1 gene methylation. Cervical cells were collected from women who referred …

Characterization Of Mait Tcr Repertoire Of Gastrointestinal Tract And Peripheral Blood Mait Cells, Thidarat Kongkaew

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mucosal-associated invariant T (MAIT) cells are an innate-like T cell that rapidly respond to infection. MAIT cells are αβ T cells that possess a Vα7.2 (TRAV1-2) TCR with mostly pairing to TRAJ33, TRAJ20 or TRAJ12 and predominantly TRBV20-1, TRBV6-1 and TRBV6-4. MAIT T cell receptors (TCR) repertoire have been previously studied in peripheral blood. However, data on MAIT TCR repertoire in gastrointestinal tract are lacking. We studied 2 individuals who are underwent esophagogastroduodenoscopy (EGD) and colonoscopy. Blood and biopsies were obtained. PBMCs were isolated from blood and LPLs were isolated from biopsies. Due to the low number of MAIT cells …

Measurement Of The Whole Body, Eye Lens And Extremity Occupational Exposures In Nuclear Medicine Staff At King Chulalongkorn Memorial Hospital, Siriwan Sisai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Due to the epidemiology evidence of cataract and eye lens opacity, ICRP Publication 118 in 2012, recommended the new eye lens dose limit of occupational exposure at 20 mSv/year, averaged over 5-year periods, no single year exceeding 50 mSv. For the public eye lens dose limit is 15 mSv/year. After ICRP changed the eye lens dose limit, many reports on eye lens dose measurement using thermoluminescent dosimeter (TLD) from interventional radiologists and interventional cardiologists were published. Few reports on eye lens dose measurement in nuclear medicine (NM) personnel were found. The primary objective of this study is to measure whole …

Dosimetric Comparison Between Single And Double Isocenters Volumetric Arc Therapy For Stereotactic Radiotherapy With Multiple Targets, Wai Lwin Lwin Kyaw

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study was to evaluate the dosimetric effects between single isocenter (SI) and double isocenters (DI) VMAT SRT of multiple brain metastases. There are two parts of study, which were experimental for energy selection, technique comparison and clinical part to use appropriate technique. As the first part, three lesions with 3 cm distance apart and 1 cm size for all lesions were created as standard plan by varying energy. Twelve VMAT SRT plans by varying energy with 6 MV, 10 MV, 6 FFF and 10 FFF were planned on simulated three lesions of CT image. 18 VMAT …

Development Of A Clinically Feasible Translational Medical Approaches In The Treatment Of Pseudomonas Aeruginosa And Acinetobacter Baumannii Persistent Biofilm Infections., Dhammika Leshan Wannigama

Chulalongkorn University Theses and Dissertations (Chula ETD)

Despite strengthened antimicrobial therapy, biofilm infections of Pseudomonas aeruginosa and Acinetobacter baumannii are associated with poor prognosis and limited therapeutic options. Assessing antibiotics on planktonic bacteria can result in failure against biofilm infections. Currently, antibiotics to treat biofilm infections are administered empirically, usually without considering the susceptibility of the biofilm objectively before beginning treatment. For effective therapy to resolve biofilm infections it is essential to assess the efficacy of commonly used antibiotics against biofilms. Here, we offer a robust and simple assay to assess the efficacy of antibiotics against biofilms. In the present work, we carefully optimized the incubation time, …

Qualitative And Quantitative Morphological Study Of Flexor Hallucis Longus Implicated In Tendon Harvesting And Transfer, Perin Wan-Ae-Loh

Chulalongkorn University Theses and Dissertations (Chula ETD)

Flexor hallucis longus (FHL) transfer is a widely used technique for reconstruction of Achilles tendinopathies, but the complications such as neurovascular injury and functional loss of toes have been reported. This study aimed to evaluate the morphology of FHL musculotendinous junction (MTJ), location of MKH in reference to the landmarks in foot, type and morphometry of tendinous interconnection between FHL and flexor digitorum longus (FDL) tendons and FHL tendon length in single incision, double incision and minimally invasive techniques. The dissection was performed in 104 embalmed and 62 soft cadaveric feet. The result showed type 1 (87.3%) and type 3 …

Serum Microrna Profile And Serum Neuron Specific Enolase, S-100, And Interleukin-6 Level As Biomarkers For Differentiating Acute Vertigo Between Cerebellar Or Brainstem Infarction And Peripheral Vertigo, Naruchorn Kijpaisalratana

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background and PurposeAcute vertigo is a common presentation of inner ear disease. However, it can also be caused by more serious conditions, especially posterior circulation stroke. Differentiation between these 2 conditions by clinical presentations and imaging studies during acute phase can be challenging. This study aims to evaluate the serum microRNA profile and serum neuron specific enolase (NSE), S-100, and interleukin-6 (IL-6) level as potential biomarkers to differentiate between patients with central vertigo due to cerebellar or brainstem infarction and peripheral vertigo.MethodsIn the discovery phase, miRNA expression profiling was performed by Nanostring nCounter Technology in serum of patients with central …

Proximal Caries Detection On Smartphone Display, Napas Lappanakokiat

Chulalongkorn University Theses and Dissertations (Chula ETD)

The aim of this study was to compare diagnostic accuracy in proximal caries detection between bitewing radiographs exported from PACS software and taken with a smartphone viewed in a smartphone display. A total of 200 proximal surfaces from digital bitewing radiographs were included in this study. Images of all radiographs were captured from a medical-grade and a common display by an iPhone 8 Plus and stored as JPEG files. Exported DICOM files were converted into JPEG format and transferred to the smartphone used for image capturing. Each proximal surface was rated by 7 observers with 5-point-scale. Weighted kappa test was …

Protein Expression And Inflammatory Response After Delivery Of Mrna Encoding Platelet-Derived Growth Factor-Bb In Sucrose Citrate Buffer Into Rat Gingiva, Phan Bhongsatiern

Chulalongkorn University Theses and Dissertations (Chula ETD)

Messenger RNA (mRNA) has emerged as a novel therapeutic modality in medical fields, including regenerative medicine. The concept of mRNA-based therapy is to use synthesized mRNA encoding therapeutic protein delivered to target tissue. Thus, mRNA encoding growth factor could be a promising alternative to recombinant protein. Platelet-derived growth factor (PDGF) is one of most extensively studied growth factors for periodontal regeneration. To date, mRNA therapy has never been explored in the field of periodontal regeneration. The aim of the study is to examine the effect of nucleoside-modified mRNA encoding PDGF-BB on the level of PDGF-BB protein and inflammatory response at …

The Use Of Modified Mrna Encoding Platelet-Derived Growth Factor-Bb As An Innovation In Periodontal Regeneration, Theeraphat Surisaeng

Chulalongkorn University Theses and Dissertations (Chula ETD)

Since the mRNA platform has been recently introduced to several fields in medicine and the achievement of periodontal regeneration is currently unpredictable, therefore, the use of mRNA technology is a promising approach to pursue the complete periodontal regeneration. The aims of this study are to learn if mRNA encoding platelet-derived growth factor-BB (PDGF-BB) induces PDGF production in human periodontal ligament cells (PDLCs) and to investigate the effect of secreted PDGF on PDLC proliferation and promoting endothelial cell tube formation. PDLCs were obtained from extracted teeth of healthy periodontal patients. The N1-methylpseudouridine modified mRNA encoding PDGF-BB were transfected into PDLCs. The …

Taxonomy, Bioactivities, And Secondary Metabolites Of Endophytic Actinomycetes Isolated From Medicinal Plants, Nattaporn Klykleung

Chulalongkorn University Theses and Dissertations (Chula ETD)

Fifty endophytic actinomycetes isolated from six medicinal plants in Thailand were identified as Micromonospora (34 strains), Streptomyces (8 strains), Microbispora (3 strains), Nonomuraea (2 strains), Plantactinospora (2 strains), and Amycolatopsis (1 strain) based on phenotypic characteristics and 16S rRNA gene sequencing. Fifteen strains exhibited antimicrobial activity against Gram-positive bacteria. Strain CR1-09T, proposed as Microbispora cathalanthi sp. nov. was active against Staphylococcus aureus ATCC 6538 and Kocuria rhizophila ATCC 9341. Streptomyces sp. 3MP-10 and 3MP-14, novel species were active against S. aureus ATCC 6538, K. rhizophila ATCC 9341, and Bacillus subtilis ATCC 6633. Strains CR1-09T and PA1-07 showed cytotoxicity against HepG2 …

Dna Barcoding Coupled With High Resolution Melting (Bar-Hrm) Analysis For Differentiation White Kwao Khruea (Pueraria Candollei), Black Kwao Khruea (Mucuna Macrocarpa), And Red Kwao Khruea (Butea Superba), Nonthapon Vejpanich

Chulalongkorn University Theses and Dissertations (Chula ETD)

Kwao Khruea is the herbal product that known as a rejuvenation herb. In Thai traditional medicine, three species of Kwao Khruea including white Kwao Khruea (Pueraria candollei Wall. ex Benth.), black Kwao Khruea (Mucuna macrocarpa Wall.) and red Kwao Khruea (Butea superba Roxb. ex Willd.) have been used. Each Kwao Khruea accumulates different chemical constituents. White Kwao Khruea contains estrogenic biological activities while black and red Kwao Khruea accumulate testosterone-like activities. Black Kwao Khruea was reported to be potent than red Kwao Khruea. Because of similar common names with the difference in chemical compositions of Kwao Khruea herbs, it is …

Development Of Cyclodextrin-Based Pickering Nanoemulsion Containing Amphotericin B For Treatment Of Fungal Keratitis, Phyo Darli Maw

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study was to develop pickering nanoemulsions (NEs) containing amphotericin B (AmB) for fungal keratitis therapy. The phase-solubility profiles of AmB in various aqueous cyclodextrin (CD) solutions were determined. The AmB solubilization in oils and surfactants was also examined. Two CDs i.e., gCD and 2-hydroxypropyl-g-CD (HPgCD), medium-chain triglycerides (MCT oil) and phosphatidylcholine (lecithin) were chosen because of their high solubility increment of AmB. Solution-state by 1H-NMR studies demonstrated the formation of MCT oil/αCD, AmB/gCD and AmB/HPgCD complexes. Some interactions between AmB and CD have been observed by solid-state characterizations (FT-IR, PXRD and DSC). The interfacial tension at …

Expression Of Human Dentin Matrix Protein 1 In Escherichia Coli And Nicotiana Benthamiana And Their Effect On Proliferation And Osteogenic Differentiation Of Human Periodontal Ligament Stem Cells, Aktsar Roskiana Ahmad

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to express recombinant protein human Dentin Matrix Protein 1 (hDMP1) in Escherichia coli and Nicotiana benthamiana and investigated the osteogenic differentiation effects in human Periodontal Ligament Stem Cells (hPDLSCs). The gene encoding hDMP1 was ligated into the pET22b and pBY2R2e expression vectors. Recombinant hDMP1 protein has been productively expressed in E. coli and N. benthamiana. E. coli-produced hDMP1 resulted in 60 kDa and 100, and the optimal condition to produce highly expression was demonstrated at 0.5 mM IPTG and incubation at 37oC for 6 hr. N. benthamiana-produced hDMP1 protein showed in a 100 kDa that indicated the …

Factors Of Age, Anthropometric Characteristics And Lower Extremity Strength On Multi-Directional Reach Test In Typical Children Aged 7 - 12 Years, Benjaporn Hirunyaphinun

Chulalongkorn University Theses and Dissertations (Chula ETD)

The purpose of this study was to investigate the associations of age, anthropometric characteristics and lower extremity strength with the Multi-Directional React Test (MDRT). Sixty children with typical development, aged 7 to 12 years old, were categorized into each age group. Pearson correlation coefficient and Spearman rank correlation coefficient were conducted to examine the relationship between interesting variables (age, anthropometric characteristics and lower extremity strength) and the reach distances in forward, backward, leftward and rightward directions. The results of this study showed that multi-directional reach distances increased with age for all directions. Fair to moderate relationship (r = 0.28 – …

Responsiveness Of The Thai Version Of The Patient Reported Outcomes Measurement Information System-29 (Promis-29) In Patients With Chronic Low Back Pain, Kornkanok Khutok

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: The Patient-Reported Outcomes Measurement Information System-29 (PROMIS-29) questionnaire assesses 7 health related quality of life domains. However, research to evaluate the responsiveness and minimal clinically important differences (MCIDs) of the PROMIS-29 scores in patients with chronic low back pain (cLBP) is limited. Purpose: To evaluate responsiveness and estimate the MCIDs for PROMIS-29 scales in patients with cLBP. Method: One hundred and eighty-three participants with cLBP took part in the study. They completed the PROMIS-29 scales at baseline, 4 weeks, and 8 weeks of the study. Responsiveness of the PROMIS-29 scale scores was evaluated by examining the mean change scores, …

Curling Probe Measurement In Plasma, Chatchai Sirithipvanich

Chulalongkorn University Theses and Dissertations (Chula ETD)

The curling probe is one of the active resonance absorption spectroscopic methods, the methods utilized the probe reflection coefficient spectrum to determine the plasma density. The proposed model of the curling probe uses the deviation of the most matched frequency, the frequency in which the minimum reflection coefficient occurs, when the probe is submerged in different mediums. The probe structure is simple and claimed to be robust and efficient. The experiments of a curling probe were performed and the simulations for the probe reflection coefficient for both previously reported probe and the constructed probe configuration have been conducted. The previously …

Effects Of Magnesium Substitution On Electronic Properties Of Calcium Difluoride, Natthasart Chintananon

Chulalongkorn University Theses and Dissertations (Chula ETD)

We use density functional theory to find the phase transitions of CaF2. The results show that CaF2 adopts the fluorite structure, with the space group Fm-3m, in the range 0f 0-8 GPa and transforms into the cotunnite structure, with the space group Pnma, above 8 GPa. The electronic band structure of the Pnma-CaF2 structure expresses an insulating phase, and the bandgap collapses under pressure above 70 GPa. In this work, we proposed a new decoration of Ca/Mg-substituted fluorides MgxCa1-xF2, using the cluster expansion technique which is commonly used to study alloys. We found that the Mg0.25Ca0.75F2, with a Pm structure, …

Effects Of Non-Albicans Candida Species On Biofilm Formation And Acidogenicity Of Dual-Species Biofilms And On Cariogenic Virulence Gene Expression Of Streptococcus Mutans, Wirunphat Sansanoa

Chulalongkorn University Theses and Dissertations (Chula ETD)

Early childhood caries is a common oral disease found in children which could affect their general health. Streptococcus mutans is an important cariogenic pathogen since it possesses cariogenic properties, which are acid production, acid tolerance and biofilm formation. Recent studies showed that Candida albicans, which is frequently found together with S. mutans in plaques of children with dental caries, enhances cariogenicity. At the same time, increasing prevalence of non-albicans Candida species (NACs) in children and immune-compromised patients has been reported. Therefore, this study aims to investigate the effects of NACs when co-cultured with S. mutans on cariogenic properties and virulence …

การพัฒนารูปแบบกระบวนการแปลงสภาพองค์การสู่ตําแหน่งทางยุทธศาสตร์ของมหาวิทยาลัยเอกชนไทย, พิธากรณ์ ธนิตเบญจสิทธิ์

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อวิเคราะห์ปัจจัยการเปลี่ยนแปลงและผลกระทบที่มีต่อมหาวิทยาลัยเอกชนไทยในอนาคต ประเมินศักยภาพความพร้อมของมหาวิทยาลัยเอกชนไทยสู่ตำแหน่งทางยุทธศาสตร์ และนำเสนอรูปแบบกระบวนการแปลงสภาพองค์การสู่ตำแหน่งทางยุทธศาสตร์ของมหาวิทยาลัยเอกชนไทย ประชากรและกลุ่มตัวอย่างในการวิจัยนี้แบ่งออกได้ 5 กลุ่ม รวมจำนวน 33 คน ใช้วิธีการเลือกแบบเจาะจง ได้แก่ 1) กลุ่มผู้ที่ให้ข้อมูลปัจจัยการเปลี่ยนแปลงและผลกระทบที่มีต่อมหาวิทยาลัยเอกชนไทย ได้แก่ ผู้บริหารด้านนโยบายการอุดมศึกษา ผู้แทนคณะกรรมการองค์กรเครือข่ายการบริหารมหาวิทยาลัยเอกชนไทย อธิการบดีหรือผู้บริหารระดับสูงของมหาวิทยาลัยเอกชนไทย และผู้แทนองค์กรภาคธุรกิจ จำนวน 10 คน 2) กลุ่มผู้ที่ให้ข้อมูลเกี่ยวกับจุดเน้นและการประเมินตนเอง ได้แก่ ผู้ประเมินการประกันคุณภาพระดับสถาบันตามเกณฑ์เครือข่ายการประกันคุณภาพมหาวิทยาลัยอาเซียน เกณฑ์คุณภาพการศึกษาเพื่อการดำเนินการที่เป็นเลิศ เกณฑ์สำนักงานรับรองมาตรฐานและประเมินคุณภาพการศึกษา (องค์การมหาชน) และเกณฑ์สำนักงานคณะกรรมการการอุดมศึกษา จำนวน 8 คน 3) กลุ่มผู้ที่ให้ข้อมูลเกี่ยวกับการผลิตบัณฑิตตามจุดเน้นที่เป็นตำแหน่งทางยุทธศาสตร์ ได้แก่ ผู้แทนองค์กรภาคธุรกิจ ภาครัฐ และ รัฐวิสาหกิจ จำนวน 6 คน 4) กลุ่มผู้บริหารมหาวิทยาลัยเอกชนไทยที่ทดลองใช้เครื่องมือที่ผู้วิจัยได้พัฒนาขึ้น จำนวน 1 สถาบัน และ 5) กลุ่มผู้ทรงคุณวุฒิและผู้บริหารสถาบันอุดมศึกษาเอกชน จำนวน 7 คน ในการจัดทำการสนทนากลุ่ม สำหรับเครื่องมือที่ใช้ในการเก็บรวบรวมข้อมูล ได้แก่ แบบวิเคราะห์สาระ แบบสัมภาษณ์ แบบตรวจสอบและประเมิน ซึ่งเครื่องมือวิจัยทุกชุดได้รับการตรวจสอบจากผู้ทรงคุณวุฒิ ผลการศึกษาพบว่า มหาวิทยาลัยเอกชนไทยจำเป็นต้องปรับตัวโดยการแปลงสภาพองค์การไปสู่จุดเน้นหรือตำแหน่งทางยุทธศาสตร์ มหาวิทยาลัยต้องประเมินศักยภาพความพร้อมของสถาบันใน 2 ด้าน คือ บริบทและองค์ประกอบ ซึ่งจะทำทราบถึงระดับศักยภาพและความพร้อมในด้านต่าง ๆ การศึกษาพัฒนารูปแบบกระบวนการแปลงสภาพองค์การสู่ตำแหน่งทางยุทธศาสตร์ของมหาวิทยาลัยเอกชนไทย ประกอบไปด้วย 4 ขั้นตอน ได้แก่ 1) การประเมินเพื่อการแปลงสภาพองค์การ 2) การวางแผนการแปลงสภาพองค์การ 3) การนำโปรแกรมการแปลงสภาพองค์การไปสู่การปฏิบัติ และ 4) การตรวจสอบ ติดตามการแปลงสภาพองค์การ ประกอบการใช้กลยุทธ์การดำเนินงาน (PRIME) เพื่อยกระดับและพัฒนาศักยภาพความพร้อมในมิติต่าง ๆ สู่ตำแหน่งทางยุทธศาสตร์ ทั้งที่เป็นมิติความพร้อมเชิงบริบทของมหาวิทยาลัยและมิติความพร้อมเชิงองค์ประกอบให้บรรลุผลตามเป้าหมายร่วมกัน โดยรูปแบบกระบวนการแปลงสภาพองค์การสู่ตำแหน่งทางยุทธศาสตร์ของมหาวิทยาลัยเอกชนไทยตามผลการศึกษานี้สามารถเรียกชื่อว่า “4 Trans-Process Model”

Prediction Of Lncrna-Protein Interactions Based On Deep Learning Model, Natsuda Navamajiti

Chulalongkorn University Theses and Dissertations (Chula ETD)

One main function of long non-coding RNAs (lncRNAs) is to act as a scaffold facilitating multiple proteins to form complexes. Most of available prediction models for protein-RNA interactions, however, were proposed as a binary classifier, which limited on predicting the interaction between the non-coding RNAs and each individual RNA-binding protein (RBP). Hence, to predict if a lncRNA is acting as a scaffold, we consider this problem as a multiclass multilabel classification problem. To solve this problem, the high confident CLIP-seq data were selected from the POSTAR2 database with an augmentation of the data for the RBP classes with a small …

Elastic Half-Plane Under Surface Excitations With Consideration Of Couple Stress And Surface Stress Effects, Toan Minh Le

Chulalongkorn University Theses and Dissertations (Chula ETD)

This thesis presents the modeling and analysis of an elastic half-plane under the surface loading and the frictionless contact of a rigid indentor by taking the influence of both surface and couple stresses into account. The corresponding boundary value problem is formulated by adopting the surface elasticity and couple stress theories. The method of Fourier integral transform is employed together with the boundary conditions on the top surface to derive the complete elastic field of the half-plane subjected to arbitrary surface loadings. The proposed solution scheme is also applied to construct a set of fundamental solutions associated with a normal …

The Role Of Angular Momentum In The Interplay Between Disk Galaxies And Their Host Dark Matter Halos: Corollaries For The Hubble Fork Diagram, Angela Collier

Theses and Dissertations--Physics and Astronomy

A majority of disk galaxies host stellar bars that regulate and amplify the flow of angular momentum, J, between disks and their parent dark matter (DM) halos. These bars constitute the prime factor driving internal galaxy evolution. Yet, a non-negligible fraction of disks lack this morphological feature, which led to adoption of the Hubble Fork Diagram. The complex evolution of barred galaxies has been studied by means of numerical simulations, complemented by observations. Despite prolonged efforts, many fundamental questions remain, in part because cosmological simulations still lack the necessary resolution to account for resonant interactions and simulations of isolated …

Electronic Properties Of Atomically Thin Material Heterostructures, M. Javad Farrokhi

Theses and Dissertations--Physics and Astronomy

There is a movement in the electronic industry toward building electronic devices with dimensions smaller than is currently possible. Atomically thin 2D material, such as graphene, bilayer graphene, hBN and MoS2 are great candidate for this goal and they have a potential set of novel electronic properties compare to their bulk counterparts due to the exhibition of quantum confinement effects. To this goal, we have investigated the electric field screening of multilayer 2D materials due to the presence of impurity charge in the interface and vertical electric fifield from back gate. Our result shows a dramatic difference of screening behavior …

Magnetic Field Monitoring In The Sns Neutron Edm Experiment, Alina Aleksandrova

Theses and Dissertations--Physics and Astronomy

It is a well known fact that the visible universe is made almost entirely of baryonic matter. Yet, this is also one of the greatest puzzles that physicists are trying to solve: Where did all of this matter come from in the first place? The Standard Model (SM) of particle physics predicts a baryon asymmetry that is much smaller than what is observed in nature. In order to try and explain this discrepancy, Sakharov (1967) postulated three necessary conditions for baryogenesis in the early universe. One of these is the requirement that charge conjugation (C) and the product of C …

Knob-Socket Investigation Of Stability And Specificity In Alpha-Helical Secondary And Quaternary Packing Structure, Taylor Renee Rabara

University of the Pacific Theses and Dissertations

The novel knob-socket (KS) model provides a construct to interpret and analyze the direct contributions of amino acid residues to the stability in α-helical protein structures. Based on residue preferences derived from a set of protein structures, the KS construct characterizes intra- and inter-helical packing into regular patterns of simple motifs. The KS model was used in the de novo design of an α-helical homodimer, KSα1.1. Using site-directed mutagenesis, KSα1.1 point mutants were designed to selectively increase and decrease stability by relating KS propensities with changes to α-helical structure. This study suggests that the sockets from the KS Model can …

Required, Permissible, And Impermissible Forms Of Federal Judicial Assistance To Self-Represented Litigants: Toward Establishment Of A Judicial Duty Of Reasonable Assistance, Jona Goldschmidt

Cardozo Journal of Equal Rights & Social Justice

The article examines the evolving role of judicial assistance to self-represented litigants (SRLs) in federal courts, arguing that while the Supreme Court has maintained a strict no-assistance policy, lower courts have increasingly recognized the need for accommodations to ensure fair trials. The author advocates for a more consistent and expansive approach to judicial assistance, aligning with due process and the constitutional right to self-representation, while emphasizing the importance of maintaining judicial impartiality.

Msg-Fast: Metagenomic Shotgun Data Fast Annotation Using Microbial Gene Catalogs, Stuart M. Brown, Hao Chen, Yuhan Hao, Bobby P. Laungani, Thahmina A. Ali, Changsu Dong, Carlos Lijeron, Baekdoo Kim, Claudia Wultsch, Zhiheng Pei, Konstantinos Krampis

Publications and Research

Background: Current methods used for annotating metagenomics shotgun sequencing (MGS) data rely on a computationally intensive and low-stringency approach of mapping each read to a generic database of proteins or reference microbial genomes.

Results: We developed MGS-Fast, an analysis approach for shotgun whole-genome metagenomic data utilizing Bowtie2 DNA-DNA alignment of reads that is an alternative to using the integrated catalog of reference genes database of well-annotated genes compiled from human microbiome data. This method is rapid and provides high-stringency matches (>90% DNA sequence identity) of the metagenomics reads to genes with annotated functions. We demonstrate the use of this …