Digital Commons Network^™

Impulsivity In The Lphn3 (Adgrl3) Knockout Rodent: Relevance To Attention-Deficit/Hyperactivity Disorder, Hunter Glen Nolen

Electronic Theses and Dissertations Archive

Children diagnosed with attention-deficit/hyperactivity disorder often suffer from impulsivity. The attenuated expression of latrophilin 3 (Lphn3) gene is linked to a dampening of extracellular dopamine (DA) levels that is consistent with the ADHD pathology expressed in humans, while this depletion of DA levels occurring as a result of Lphn3 variation also leads to impulsivity deficits that mirror those that are observed in humans sufferring from ADHD. The present study aimed to assess two different facets of impulsivity to offer a more complete assessment of the influence of Lphn3 variation on impulsive behavior. Compared to controls, Lphn3 knockout (KO) rats exhibited …

Generation Of An Oncolytic Adenovirus Targeting The Cxcr4 And Cxcr7 Chemokine Receptors In Breast Cancer, Samia Melissa O'Bryan

LSU Doctoral Dissertations

Breast cancer is the most diagnosed cancer in women under 60 and the second most diagnosed cancer in women over 60. While treatments for localized breast cancer are quite successful with high survival rates at 99%, advanced breast cancer remains hard to treat with a nearly 75% decrease in survival. Current treatments are inefficient at treating advanced stages of breast cancer, and thus, new therapies are sorely needed to address the complexity of advanced stage breast cancer. The ideal therapy would be capable of systemic administration, targets cancer cells and spares normal tissue. Oncolytic adenovirus is an ideal therapeutic vector …

Reflections Of Representing Incarcerated People With Disabilities: Ableism In Prison Reform Litigation, Jamelia N. Morgan

Denver Law Review

No abstract provided.

Ideology And Risk Focus: A Preliminary Exploration Of The Effect Of Judicial Ideology On Risk Focus In Supreme Court Opinion Construction, Gordon Ballingrud, Caitlein Jammo

Denver Law Review

No abstract provided.

The Gene Silencing Protein Morc-1 Topologically Entraps Dna And Forms Multimeric Assemblies To Cause Dna Compaction., Hyeongjun Kim, Linda Yen, Somsakul P. Wongpalee, Jessica A. Kirshner, Nicita Mehta, Yan Xue, Jonathan B. Johnston, Alma L. Burlingame, John K. Kim, Joseph J. Loparo, Steve E. Jacobsen

Physics & Astronomy Faculty Publications

Highlights

• Caenorhabditis elegans MORC-1 traps DNA loops

• Recruitment of additional MORC-1s cause further loop trapping and DNA compaction

• MORC-1 assemblages become topologically entrapped on DNA

• MORC-1 forms discrete foci in vivo and can phase transition in vitro

Summary

Microrchidia (MORC) ATPases are critical for gene silencing and chromatin compaction in multiple eukaryotic systems, but the mechanisms by which MORC proteins act are poorly understood. Here, we apply a series of biochemical, single-molecule, and cell-based imaging approaches to better understand the function of the Caenorhabditis elegans MORC-1 protein. We find that MORC-1 binds to DNA in a length-dependent but sequence non-specific …

Diagnosis In 2.127 Seconds: Solving A Years-Long Vomiting Mystery Using Ai, Research And Brain Power, Staff

Browse All News

No abstract provided.

V International Colloquium Proceedings, International Colloquium

Proceedings of the International Colloquium on Languages, Cultures, Identity in School and Society

No abstract provided.

Adolescents' Digital Literacies In Flux: Intersections Of Voice, Empowerment, And Practices, Sandra Schamroth Abrams, Mary Beth Schaefer, Daniel Ness

Journal of Media Literacy Education

This article features a collaborative autoethnographic examination of three adolescent-researchers’ digital literacies. The participatory design punctuates the role of the adolescent-researchers as they explored their meaning-making practices. Such collaborative research, which included three adolescents and their parents, not only resurfaces parent-inquiry, but also brings the adolescent-researcher voice to the forefront of literacy research. Two research questions guided the investigation: (a) What do adolescent-researchers tell us about their digital and nondigital literacy practices? and (b) In what ways do adolescent-researchers’ retrospective examinations of their own practices reveal their perspectives of these practices and the power (and power struggles) that underlie them? …

Media Literacy Education In The Age Of Machine Learning, Teemu Valtonen, Matti Tedre, Kati Mäkitalo, Henriikka Vartiainen

Journal of Media Literacy Education

The media environment has radically changed over the past few decades. Transition and transformation of media platforms has enabled algorithms and automation to take over media processes such as production, content generation, curation, delivery, recommendation, and filtering of information. It has also enabled tracking of users’ actions, data mining, profiling, and the use of computational and machine learning techniques for purposes like behavior engineering, targeted advertisement, spread of mis- and disinformation, swaying political moods, and many others. In the field of media literacy education, the need to understand algorithm-driven media requires educators to re-think the connections between media literacy education …

Chapter 5: ‘Ghana Calls’ To Ud, Laura M. Leming F.M.I.

Myth and Reality: Reflections on Our Travels through West Africa

A reflection on the 2018-19 Global Education Seminars in West Africa.

What’S In A Name? The Morality In “Meat”, Rachel Robinson-Greene

Languages, Philosophy, and Communication Studies Faculty Publications

In 2018, Missouri banned the use of the word “meat” to describe products that are “not derived from harvested production livestock or poultry.” As punishment, “Violators are subject to up to one year in prison and a fine of as much as $1,000.” The law was written in response to the rise in popularity of realistic meat substitutes such as Impossible Burger and Beyond Meat and to the emerging technology of cell cultured meats. Similar laws followed in states such as Arkansas, Louisiana, Mississippi, Nebraska, and South Dakota.

Against All Odds, Coco's Story, Estelle Raballand

Tales of WellBeing

Coco, a chimpanzee orphaned by the illegal pet trade in Guinea and left severely disabled after years of neglect and violence, has survived against extraordinary odds thanks to the care and dedication of the Chimpanzee Conservation Center. His story highlights both the resilience of individual animals and the urgent need for sanctuaries and conservation efforts to protect the critically endangered West African chimpanzee.

Hydrophobic Sand Is A Viable Method Of Urine Collection From The Rat For Extracellular Vesicle Biomarker Analysis, Jessica F. Hoffman, Ivan J. Vechetti Jr, Alexander P. Alimov, John F. Kalinich, John J. Mccarthy, Charlotte A. Peterson

Department of Nutrition and Health Sciences: Faculty Publications

Previously we have shown in rats a new method of urine collection, hydrophobic sand, to be an acceptable alternate in place of the traditional method using metabolic cages. Hydrophobic sand is non-toxic, induces similar or lower levels of stress in the rat, and does not contaminate clinical urine markers nor metal concentrations in collected samples (Hoffman et al., 2017 and 2018). Urine is often used in humans and many animal models as a readily-attainable biosample which contains proteins and microRNAs (miRNAs) within extracellular vesicles (EVs) that can be isolated to indicate changes in health. In order to ensure hydrophobic sand …

Sensorimotor Coding Of Vermal Granule Neurons In The Developing Mammalian Cerebellum, Kelly H. Markwalter, Yue Yang, Timothy E. Holy, Azad Bonni

Open Access Publications

The vermal cerebellum is a hub of sensorimotor integration critical for postural control and locomotion, but the nature and developmental organization of afferent information to this region have remained poorly understood

Impacts Of Hiv Cure Interventions On Viral Reservoirs In Tissues, Paul W. Denton, Ole S. Søgaard, Martin Tolstrup

Biology Faculty Publications

HIV reservoirs persist in infected individuals despite combination antiretroviral therapy and can be identified in secondary lymphoid tissues, in intestinal tissues, in the central nervous system as well as in blood. Clinical trials have begun to explore effects of small molecule interventions to perturb the latent viral infection, but only limited information is available regarding the impacts of HIV cure-related clinical interventions on viral reservoirs found in tissues. Of the 14 HIV cure-related clinical trials since 2012 that have evaluated the effects of small molecule interventions in vivo, four trials have examined the impacts of the interventions in peripheral …

Evolutionary History Predicts High‐Impact Invasions By Herbivorous Insects, Angela M. Mech, Kathryn A. Thomas, Travis D. Marsico, Daniel A. Herms, Craig R. Allen, Matthew P. Ayres, Kamal J.K. Gandhi, Jessica Gurevitch, Nathan P. Havill, Ruth A. Hufbauer, Andrew M. Liebhold, Kenneth F. Raffa, Ashley N. Schulz, Daniel R. Uden, Patrick C. Tobin

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

1. A long‐standing goal of invasion biology is to identify factors driving highly variable impacts of non‐native species. Although hypotheses exist that emphasize the role of evolutionary history (e.g., enemy release hypothesis & defense‐free space hypothesis), predicting the impact of non‐native herbivorous insects has eluded scientists for over a century.

2. Using a census of all 58 non‐native conifer‐specialist insects in North America, we quantified the contribution of over 25 factors that could affect the impact they have on their novel hosts, including insect traits (fecundity, voltinism, native range, etc.), host traits (shade tolerance, growth rate, wood density, etc.), and …

Mom’S Key To Longevity: Oatmeal And Prayers, Camille Dolan

UCF Forum

My mother turns 88 this November. She is still working at a department store where she has been for more than 30 years. Her customers ask her two things: Why hasn’t she retired yet and how does she keep going?

Human Auditory Discrimination Of Bottlenose Dolphin Signature Whistles Masked By Noise: Investigating Perceptual Strategies For Anthropogenic Noise Pollution, Evan L. Morrison

Theses

Anthropogenic masking noise in the world’s oceans is known to impede many species’ ability to perceive acoustic signals, but little research has addressed how this noise pollution affects the detection of bioacoustic signals used for communication. Bottlenose dolphins (Tursiops truncatus) use signature whistles which contain identification information. Past studies have shown that human participants can be used as models for dolphin hearing, but most previous research investigated echolocation. In Experiment 1, human participants were tested on their ability to auditorily discriminate among signature whistles from three dolphins. Participants’ performance was nearly errorless (M = 98.8%). In Experiment 2, participants identified …

Acquisitions Unit Annual Report 2018-2019, Andrée J. Rathemacher

Technical Services Reports and Statistics

Annual Report of the Acquisitions Unit, University Libraries, University of Rhode Island for FY2019. Covers personnel, work flow, special projects, and serial, monograph, and e-resource acquisitions. Supplemental files include data on library materials expenditures by a number of variables as well as important working documents from the year.

Occurrence Of Aflatoxin And Zearalenone In Concentrate Feeds And Milk Contamination With Aflatoxin M1 And Bacterial Pathogens In Malawi, Chunala Alexico Njombwa

LSU Doctoral Dissertations

Multiple studies were conducted in Malawi to: 1) evaluate knowledge and perception of dairy farmers towards molds, mycotoxins and associated adverse effects; 2) evaluate dairy farmers’ knowledge and perception on milk contamination, proper milk handling practices and adverse health effects associated with raw milk consumption; 3) determine levels of aflatoxins and zearalenone (ZEN) in concentrate feedstuffs; 4) assess prevalence and levels of aflatoxin M₁(AFM₁) in raw milk, dietary exposure and estimate HCC risks to children and adults; 5) assess Salmonella and E. colicontamination in raw and processed milk from selected small scale farms and major …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

A Panel Of Protein Kinase Chemosensors Distinguishes Different Types Of Fatty Liver Disease, Jon R. Beck, Fatima Cabral, Karuna Rasineni, Carol A. Casey, Edward N. Harris, Cliff I. Stains

Department of Chemistry: Faculty Publications

The worldwide incidence of fatty liver disease continues to rise, which may account for concurrent increases in the frequencies of more aggressive liver ailments. Given the existence of histologically identical fatty liver disease subtypes, there is a critical need for the identification of methods that can classify disease and potentially predict progression. Herein, we show that a panel of protein kinase chemosensors can distinguish fatty liver disease subtypes. These direct activity measurements highlight distinct differences between histologically identical fatty liver diseases arising from diets rich in fat versus alcohol and identify a previously unreported decrease in p38α activity associated with …

Identifying Phytochemicals From Biomedical Literature Utilizing Semantic Knowledge Sources, Indra Neil Sarkar, Wayne Law, Michael J. Balick

Faculty and Staff Publications & Presentations

Chemicals derived from plants (phytochemicals) are major concepts of interest in the study of medicinal plants. To date, efforts to catalogue and organize phytochemical knowledge have resorted to manual approaches. This study explored the potential to leverage publicly accessible semantic knowledge sources for identifying possible phytochemicals. Within the context of this feasibility study, putative phytochemicals were identified for more than 4,000 plants from the Medical Subject Headings Supplementary Concept Records and the Semantic MEDLINE Database. An examination of phytochemicals identified for five selected plant species using the method developed here reveals that there is a disparity in electronically catalogued phytochemical …

Are Microclimate Conditions In El Malpais National Monument Caves In New Mexico, Usa Suitable For Pseudogymnoascus Growth?, Terry J. Torres-Cruz, Andrea Porras-Alfaro, Nicole A. Caimi, Ogochukwu Nwabologu, Edward W. Strach, Kaitlyn J.H. Read, Jesse M. Young, Debbie C. Buecher, Diana E. Northup

International Journal of Speleology

White-nose syndrome (WNS) is a bat disease caused by the fungal pathogen Pseudogymnoascus destructans, which thrives in cold and very humid environments where bats frequently hibernate. Conidia of Pseudogymnoascus species are often documented on bats prior to the onset of WNS, but characterization of high-risk areas defined by microclimate cave conditions have been lacking. Investigating the occurrence of this fungal genus and appropriate environmental conditions to support P. destructans in southwestern U.S. caves is key to understanding the sites most likely to be impacted by WNS. Microclimate conditions in ten caves at El Malpais (ELMA) National Monument in New …

Using Machine Learning For Antimicrobial Resistant Dna Identification, Jason I. Lingle, John Santerre

SMU Data Science Review

In this paper, we present a novel machine learning-based methodology for identifying bacteria DNA sub-sequences that are associated with antimicrobial resistance. The dramatic rise in cases of antibiotic resistant bacteria has been an increasing threat across the globe as the existing treatments are rendered ineffective in treating most of these cases due to mutations of their DNA. Among the most recent bacteria to display antimicrobial resistance (AMR) is Neisseria Gonorrhea with the first global treatment failure taking place in 2016. In 2018, new cases of resistance to multiple, high levels of antibiotics were reported in the United Kingdom and Australia. …

Machine Learning Predicts Aperiodic Laboratory Earthquakes, Olha Tanyuk, Daniel Davieau, Charles South, Daniel W. Engels

SMU Data Science Review

In this paper we find a pattern of aperiodic seismic signals that precede earthquakes at any time in a laboratory earthquake’s cycle using a small window of time. We use a data set that comes from a classic laboratory experiment having several stick-slip displacements (earthquakes), a type of experiment which has been studied as a simulation of seismologic faults for decades. This data exhibits similar behavior to natural earthquakes, so the same approach may work in predicting the timing of them. Here we show that by applying random forest machine learning technique to the acoustic signal emitted by a laboratory …

Aws Ec2 Instance Spot Price Forecasting Using Lstm Networks, Jeffrey Lancon, Yejur Kunwar, David Stroud, Monnie Mcgee, Robert Slater

SMU Data Science Review

Cloud computing is a network of remote computing resources hosted on the Internet that allow users to utilize cloud resources on demand. As such, it represents a paradigm shift in the way businesses and industries think about digital infrastructure. With the shift from IT resources being a capital expenditure to a managed service, companies must rethink how they approach utilizing and optimizing these resources in order to maximize productivity and minimize costs. With proper resource management, cloud resources can be instrumental in reducing computing expenses.

Cloud resources are perishable commodities; therefore, cloud service providers have developed strategies to maximize utilization …

Visualizing United States Energy Production Data, Bruce P. Kimbark, Melissa Luzardo, Charles South, James Taber

SMU Data Science Review

Power plants production, load, financials and environmental impact from power plants in the United States is publicly available either from the Energy Information Administration, the Environmental Protection Agency or Lazard among others. The general public is interested in US energy production and its potential environmental impact but the available information is complex and difficult to properly understand and not shared in ways that are accessible. Our objective was to gather this data and create different interactive visualizations that make it consumable. Each of the five visualization was designed to explain a specific part of energy that together can provide a …

Antibiotic Knowledge, Attitudes And Practices: New Insights From Cross-Sectional Rural Health Behaviour Surveys In Low-Income And Middle-Income South-East Asia, Marco J. Haenssgen, Nutcha Charoenboon, Giacomo Zanello, Mayfong Mayxay, Felix Reed-Tsochas, Yoel Lubell, Heiman Wertheim, Jeffrey Lienert, Thipphaphone Xayavong, Yuzana Khine Zaw, Amphayvone Thepkhamkong, Nicksan Sithongdeng, Nid Khamsoukthavong, Chanthasone Phanthavong, Somsanith Boualaiseng, Souksakhone Vongsavang, Kanokporn Kanokporn, Poowadon Chai-In, Patthanan Thavethanutthanawin, Thomas Althaus, Rachel Claire Greer, Supalert Nedsuwan,, Tri Wangrangsimakul, Direk Limmathurotsakul, Elizabeth Elliott, Proochista Ariana

Goal 1: No Poverty

Introduction Low-income and middle-income countries (LMICs) are crucial in the global response to antimicrobial resistance (AMR), but diverse health systems, healthcare practices and cultural conceptions of medicine can complicate global education and awareness-raising campaigns. Social research can help understand LMIC contexts but remains under-represented in AMR research.

Objective To (1) Describe antibiotic-related knowledge, attitudes and practices of the general population in two LMICs. (2) Assess the role of antibiotic-related knowledge and attitudes on antibiotic access from different types of healthcare providers.

Design Observational study: cross-sectional rural health behaviour survey, representative of the population level.

Setting General rural population in Chiang …

Full Stem Ahead, Shawn Knowlton, Megan Elbel

Honors Program: Expanded Learning Clubs

After school club that introduces students to STEM and builds problem-solving skills through hands-on, interactive activities.