Digital Commons Network^™

Effects Of Solvent Used For Fabrication On Drug Loading And Release Kinetics Of Electrosprayed Temozolomide-Loaded Plga Microparticles For The Treatment Of Glioblastoma, Daniel A. Rodriguez De Anda, Nareg Ohannesian, Karen S. Martirosyan, Sue Anne Chew

Physics & Astronomy Faculty Publications

Glioblastoma multiforme (GBM) is the most common and invasive form of malignant brain tumors and despite advances in surgery, radiotherapy, and chemotherapy, the survival of patients with GBM still remains poor. Temozolomide (TMZ) is the chemotherapy drug that is most commonly given orally after surgical resection of these tumors. In this study, the effects of solvents (i.e., dichloromethane and acetonitrile) used for the fabrication of electrosprayed TMZ-loaded poly(lactic-co-glycolic acid) (PLGA) on drug loading, loading efficiency, drug release kinetics, surface morphology, and particle size were investigated. The results from this study demonstrated that by using a larger volume of a solvent …

Carbon Nanotube Reinforced Hydroxyapatite Nanocomposites As Bone Implants: Nanostructure, Mechanical Strength And Biocompatibility, K Lawton, H Le, C Tredwin, Rd Handy

School of Biological and Marine Sciences

No abstract provided.

Assessing Egyptians' Knowledge, Perceptions, And Attitudes Towards Generic Medicines, Radwa Ahmed Elmoneer

Theses and Dissertations

Medicines are vital component of any health system worldwide, and ensuring accessibility of affordable, effective and safe medications is a critical public policy goal considered by every country. Egypt has, recently, faced aggravated challenges in ensuring the availability of medications countrywide. In response, the Egyptian government has adopted a number of pharmaceutical policies and interventions, mainly, targeting the supply side of the market. Promoting the use of generic medicines is an effective policy intervention that addresses the demand side, a highly recommended intervention given other countries’ experiences. As the main users of medications, patients are a crucial source of knowledge …

Neuropsychological Sequela Of Mild Traumatic Brain Injury: A Contemporary Meta-Analytic Review, David E. Marra

Dissertations (1934 -)

Mild traumatic brain injuries (MTBIs) result in a constellation of non-specific physical, cognitive, and psychological symptoms. There is significant variability in neurocognitive recovery after MTBI, ranging from a few days to a few months, and others who fail to make complete recovery. A broad literature has attempted to elucidate what individual differences explain this variability. The present study sought to build upon previous meta-analyses, which systematically aggregated and examine relevant literature, by including a more heterogenous population and utilizing contemporary meta-analytic techniques. Three online databases (PsychINFO [sic], PubMed, MedLine) were searched for pertinent studies. Separate random-effects Analogue-to-ANOVA were utilized to …

The Fantastic Structure Of Freedom: Sartre, Freud, And Lacan, Gregory A. Trotter

Dissertations (1934 -)

This dissertation reassesses the complex philosophical relationship between Sartre and psychoanalysis. Most scholarship on this topic focuses on Sartre’s criticisms of the unconscious as anathema both to his conception of the human psyche as devoid of any hidden depths or mental compartments and, correlatively, his account of human freedom. Many philosophers conclude that there is little common ground between Sartrean existentialism and psychoanalytic theory. I argue, on the contrary, that by shifting the emphasis from concerns about the nature of the unconscious to questions about the role of imagination in psychical life, we can see that Sartre and Freudian-Lacanian psychoanalytic …

The Impact Of Isometric Exercise On Somatosensory Processing In People With Or Without Chronic Pain, Ali Mohammed Alsouhibani

Dissertations (1934 -)

Despite an increase in our understanding of the pathomechanisms of chronic pain and the advancement of new treatments, pharmacological management of chronic pain remains poor. This presents the need for non-pharmacological treatments and understanding their efficacy and mechanisms in managing pain. The purpose of this dissertation was to examine the effects of isometric exercise on the somatosensory system and other biopsychosocial aspects related to pain in individuals with and without fibromyalgia. The first aim was to determine whether isometric exercise improves pain inhibitory mechanisms and vibration sense. The second aim was to determine what biopsychosocial factors influence pain relief following …

L’Affaire D’Antoine: Colonial Tensions Of Freedom And Power, Marisa Mancini , '20

Senior Theses, Projects, and Awards

In 1774, living in the French colony of Saint-Domingue, Antoine bought his freedom from the Gentil de Paroy, only to be arrested by his former master two years later and accused of using poison. With his mother, Lisette, a free woman of color, advocating for him, the local courts in Le Cap Français found Antoine innocent of the alleged crime and upheld his freedom only for this freedom to be revoked by the French monarchy. Situating Antoine’s case into the history of Saint-Domingue highlights the social and political contradictions surrounding citizenship and sovereignty that were inherent to colonial society in …

Impact Of An Educational Program On A Year-Round Forage Production And Grazing Management System In Alabama, Lila Karki, Uma Karki

Professional Agricultural Workers Journal

Abstract

Raising animals on supplementary feeds in the lean months is economically unfeasible due to the increasingly high price of grains and commercial feeds. The objective of this study was to estimate the economic impact of educational events on year-round pasture and grazing management. A survey was introduced through SurveyMonkey to 78 trainees to collect data on a pre-structured questionnaire. A conceptual framework of production function was applied to measure the impact of the events using a before vs. after impact assessment approach. Forty-six percent of respondents completed the survey. The results revealed that the educational events had a positive …

Barriers To Management Intensive Grazing By Southern Dairy Farmers, Mohammed Ibrahim, Nalini K. Pattanaik, Brian Cornish

Professional Agricultural Workers Journal

Abstract

Interest in Management Intensive Grazing (MIG) [a situation where grazing animals are moved to a fresh pasture every few days in order to have access to adequate forage] practices by farmers have increased steadily over the years. Many research publications on grazing advocate the financial and environmental benefits of grazing. Understanding the challenges of MIG can be an important piece of information for a dairy farmer. A survey was conducted to determine how farmers in the southeastern region perceive the barriers to the adoption of MIG. A greater percentage of MIG southeastern farmers were satisfied or very satisfied with …

A Retrospective Study Of Epa's Record Of Decision Report On The Woolfolk Arsenic And Lead Contamination In Fort Valley, Georgia, Ovigueroye L. Ojarikre, Oreta Samples, Jacques Surrency

Professional Agricultural Workers Journal

Abstract

Heavy metal contamination is a major anthropogenic challenge in communities with heavy presence of chemical industries. Most of the contamination is due to the improper disposal of chemical waste. The study involved the evaluation of the levels of arsenic and lead regarding remediation activities carried out by the Environmental Protection Agency (EPA). It compared the results of the EPA’s 1993 soil analysis of arsenic and lead, and a subsequent soil analysis of the same mapped areas. It also covered the evaluation of the level of arsenic dust in the attics of residential properties and evaluation of the EPA’s record …

Production Period Of Different Browse Species Suitable For Grazing Small Ruminants, Bidur Paneru, Uma Karki, Shailes Bhattrai, Nevershi Ellis

Professional Agricultural Workers Journal

Abstract

Browse (shrubs, trees, and vines) species are important sources of feed for small ruminants in Alabama and many other states of the U.S. Information on the production period of these species is important to prepare a year-round grazing plan to utilize them well. The objective of the study was to determine the leaf-shedding time of common browse species suitable for small ruminants. This study was conducted at the Atkins Agroforestry and Browse Research and Demonstration Site of Tuskegee University, Alabama. Ten samples of each browse species were tagged, and leaf-yellowing and leaf-fall data collected using photoplots every 14 days …

Development Of Biological Indicators For The Dry Phase Of Non-Perennial Rivers And Streams, Matthew D. Robinson

SNS Master's Theses

As perennial river systems become increasingly intermittent worldwide, there is a growing need to focus attention on developing dry-phase bioassessment tools for non-perennial rivers and streams (NPRS). NPRS play key ecological roles in watershed functioning but can be impacted by many of the same disturbances affecting perennial rivers. However, we lack tools to assess the ecological health of NPRS like the well-developed bioassessment tools used for perennial systems. For this reason, there has been an increasing need to develop biological indicators to assess the health of rivers when they are dry.

We sampled 39 streams in Southern California, USA during …

Hysterosalpingographic Findings In Primary And Secondary Infertility Patients, Khawaja B. Waheed, Muneera A. Albassam, Shayma A. Aloumi, Muhammad S. Amin, Lubna Rashid, Sarah M. Algodayan

Saudi Medical Journal

Objectives: To highlight and compare spectrum of hysterosalpingography (HSG) findings in primary and secondary infertility patients. Methods: This retrospective record-based cross-sectional study was performed in the Radiology Department, King Fahad Military Medical City, Dhahran, Kingdom of Saudi Arabia between August 2016 and 2018. All patients (N=303) who underwent successful HSGs were included, and grouped under primary and secondary infertility cases. Patients with failed, limited or incomplete studies were excluded. Imaging findings were documented as N (Normal) or Ab (Abnormal). Abnormal HSG findings were further categorized as: C=congenital malformation, I=infection or inflammation, S=surgery, T=tumor or tear. Abnormal findings were confirmed on …

The Internet Of Bodies, Andrea M. Matwyshyn

William & Mary Law Review

This Article introduces the ongoing progression of the Internet of Things (IoT) into the Internet of Bodies (IoB)—a network of human bodies whose integrity and functionality rely at least in part on the Internet and related technologies, such as artificial intelligence. IoB devices will evidence the same categories of legacy security flaws that have plagued IoT devices. However, unlike most IoT, IoB technologies will directly, physically harm human bodies—a set of harms courts, legislators, and regulators will deem worthy of legal redress. As such, IoB will herald the arrival of (some forms of) corporate software liability and a new legal …

Language Nests On The Move: The Case Of Võro Pre-Primary Education In Estonia, Kara D. Brown, Mariko Faster

Faculty Publications

This article considers the circuitous route of knowledge exchange from South (New Zealand)-to North (Finland)-to regional South (Estonia) by examining the development of Võro language nests (keelepesä) in Estonia. Language nests reflect the global nature of educational knowledge exchange as well as the importance of networks of languageresearchers and activists in this policy inspiration. Estonia is a fascinating case for understanding the international spread and local development of the language-nest approach in a post-Socialist context. The authors draw on concepts of policy borrowing and diffusion and the “grammar of schooling” to explore the spread of the language nest approach and …

Installments, Fall Issue 151, October 2019, Renee Montgomery

Libraries' Newsletters

No abstract provided.

Evaluation Of The Change In The Tongue Posture And In The Hyoid Bone Position After Twin Block Appliance Therapy In Skeletal Class Ii Subjects, Erum Afzal, Mubassar Fida

Section of Dental-Oral Maxillofacial Surgery

BACKGROUND: The tongue is posteriorly postured in a retrognathic mandible, and Twin Block appliance (TBA) therapy places the tongue and the hyoid bone in a favorable position to eliminate the risk of causing respiratory obstruction. OBJECTIVES: The aim of this study was to evaluate the change in the tongue posture and in the hyoid bone position after TBA therapy. MATERIAL AND METHODS: This cross-sectional study was conducted using the pre-functional (PF1), postfunctional (PF2) and post-treatment (PT) cephalograms of 30 growing subjects. The tongue posture at 6 distances and the hyoid bone position with 4 parameters were digitally measured using the …

Stump On Forgiveness, Richard Swinburne

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Chairs Of Excellence Annual Report 2019, Tennessee. Higher Education Commission.

Academic Programs and Workforce Reports

No abstract provided.

Vol 64 #5, Melanie Argo

MPLA Newsletter

No abstract provided.

An Intellectual History Of Mass Incarceration, Alice Ristroph

Faculty Scholarship

No abstract provided.

Multiple Sclerosis Outcomes After Cancer Immunotherapy, Catherine R. Garcia, Rani Jayswal, Val R. Adams, Lowell B. Anthony, John L. Villano

Markey Cancer Center Faculty Publications

INTRODUCTION: Neurological immune-related adverse events are a rare but potentially deadly complication after immune checkpoint inhibitor (ICI) treatment. As multiple sclerosis (MS) is an immune-mediated disease, it is unknown how ICI treatment may affect outcomes.

METHODS: We analyzed the United States Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database for pembrolizumab, atezolizumab, nivolumab, ipilimumab, avelumab, and durvalumab 2 years prior their FDA approval until December 31, 2017, to include all cases with confirmed diagnosis/relapse of MS. We also included cases reported in the literature and a patient from our institution.

RESULTS: We identified 14 cases of MS …

Reverse Zoonosis Of Pandemic A(H1n1)Pdm09 Influenza Viruses At The Swine/Human Interface, Daniel Gene Darnell

Theses and Dissertations (ETD)

The 2009 pandemic influenza A(H1N1)pdm09 virus emerged from the swine population. Despite frequent zoonotic events, swine influenza viruses had not become established in humans previously and little is known about host-barriers which prevent swine influenza viruses from efficiently infecting humans. Thus, the emergence of the H1N1pdm09 viruses in humans and the subsequent reverse zoonoses back to swine offered an extremely valuable opportunity to expand current knowledge. We used our active swine farm surveillance platform in combination with viruses from the USDA surveillance program to look for evidence of interspecies transmission of H1N1pdm09 viruses in the US. We found phylogenetic evidence …

Improving Person-Independent Facial Expression Recognition Using Deep Learning, Jie Cai

Theses and Dissertations

Over the past few years, deep learning, e.g., Convolutional Neural Networks (CNNs) and Generative Adversarial Networks (GANs), have shown promise on facial expression recog- nition. However, the performance degrades dramatically especially in close-to-real-world settings due to high intra-class variations and high inter-class similarities introduced by subtle facial appearance changes, head pose variations, illumination changes, occlusions, and identity-related attributes, e.g., age, race, and gender. In this work, we developed two novel CNN frameworks and one novel GAN approach to learn discriminative features for facial expression recognition.

First, a novel island loss is proposed to enhance the discriminative power of learned deep …

Dietary Advanced Glycation End-Products (Ages) And Breast Cancer Risk And Survival, Omonefe Opeyemi Omofuma

Theses and Dissertations

Introduction: Advanced glycation end-products (AGEs) are implicated in the pathogenesis of chronic diseases including cancer. AGEs are produced endogenously and are also consumed from foods. High amounts of AGEs are found in animal products and processed foods, and AGE formation is accelerated during cooking at high temperatures. Using data from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO), we assigned and quantified NƐ-carboxymethyl-lysine (CML)-AGE content in food and investigated the association between dietary AGE intake and breast cancer (BrCa) risk. We assessed whether the risk was modified by race/ethnicity, obesity status, fruit and vegetable intake, BrCa invasiveness …

Microbiome-Gut-Brain Axis As A Biomolecular Communication Network For The Internet Of Bio-Nanothings, Ian F. Akyildiz, Jiande Chen, Maysam Ghovanloo, Ulkuhan Guler, Tevhide Ozkaya-Ahmadov, Massimiliano Pierobon, A Faith Sarioglu, Bige D. Unluturk

School of Computing: Faculty Publications

This article presents fundamental challenges in the development of a self-sustainable and biocompatible network infrastructure to interconnect the next-generation electrical and biological wearable and implantable devices, i.e., the Internet of Bio-NanoThings. The direct contact of IoBNT devices with the human body, where the cells naturally communicate and organize into networks, suggests the possibility to exploit these biological communications for the device-to-device interconnection. The aim of this work is to investigate minimally invasive, heterogeneous, and externally accessible electrical/molecular communication channels to transmit information between these devices through the Microbiome-Gut-Brain Axis (MGBA), composed of the gut microbial community, the gut tissues, the …

Application Strategy For An Anthraquinonebased Repellent And The Protection Of Soybeans From Canada Goose Depredation, Scott J. Werner, Matthew Gottlob, Charles D. Dieter, Joshua D. Stafford

United States Department of Agriculture Wildlife Services: Staff Publications

Agricultural crops can sustain extensive damage caused by Canada geese (Branta canadensis) when these crops are planted near wetlands or brood-rearing sites. From 2000 to 2015, South Dakota Game, Fish and Parks spent >$5.6 million to manage damages caused by Canada geese to agricultural crops (primarily soybeans) in South Dakota, USA. For the purpose of developing a repellent application strategy for nonlethal goose damage management, we comparatively evaluated the width of anthraquinone applications (i.e., 9.4 L Flight Control® Plus goose repellent/ha [active ingredient: 50% 9,10-anthraquinone] at 0–36 m versus 0–73 m perpendicular to the edge of wetlands in 2014), the …

A Review Of Rat Lungworm Infection And Recent Data On Its Definitive Hosts In Hawaii, Chris Niebuhr, Susan I. Jarvi, Shane R. Siers

United States Department of Agriculture Wildlife Services: Staff Publications

Rat lungworm (Angiostrongylus cantonensis) is a zoonotic nematode that causes rat lungworm disease (angiostrongyliasis), a potentially debilitating form of meningitis, in humans worldwide. The definitive hosts for rat lungworm are primarily members of the genus Rattus, with gastropods as intermediate hosts. This parasite has emerged as an important public health concern in the United States, especially in Hawaii, where the number of human cases has increased in the last decade. Here we discuss the current knowledge of the rat lungworm, including information on the life cycle and host species, as well as updates on known infection levels. Three species of …

Estimating Waterbird Abundance On Catfish Aquaculture Ponds Using An Unmanned Aerial System, Paul C. Burr, Sathishkumar Samiappan, Lee A. Hathcock, Robert J. Moorhead, Brian S. Dorr

United States Department of Agriculture Wildlife Services: Staff Publications

In this study, we examined the use of an unmanned aerial system (UAS) to monitor fish-eating birds on catfish (Ictalurus spp.) aquaculture facilities in Mississippi, USA. We tested 2 automated computer algorithms to identify bird species using mosaicked imagery taken from a UAS platform. One algorithm identified birds based on color alone (color segmentation), and the other algorithm used shape recognition (template matching), and the results of each algorithm were compared directly to manual counts of the same imagery. We captured digital imagery of great egrets (Ardea alba), great blue herons (A. herodias), and doublecrested cormorants (Phalacrocorax auritus) on aquaculture …

In This Issuesystematic Review Articleoriginal Articlescase Seriescase Report

Saudi Medical Journal

No abstract provided.