Digital Commons Network^™

Population Health Of Spotted Salamanders (Ambystoma Maculatum) In Created Vernal Pools: An Integrative Approach, Alice R. Millikin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Habitat creation is an important tool for conservation to counteract habitat loss and degradation. Vernal pools are susceptible to destruction due to limited detection, protection, and regulation. These wetlands provide fishless breeding habitat for many amphibian species including spotted salamanders (Ambystoma maculatum) in eastern North America. Determining whether created vernal pool habitat is successful is often determined by demographic data of colonizing populations. I suggest that hormone levels, population genetics, and disease prevalence can improve our understanding of population health in created habitat. The goal of this dissertation was to assess the health of spotted salamander larvae in …

Behavioral Impairment Following Gestational Exposure To Titanium Dioxide Nanomaterial Aerosols In Male And Female Rats, Matthew Leland Eckard

Graduate Theses, Dissertations, and Problem Reports (ETD)

Engineered nanomaterials (ENMs) are beginning to be recognized as hazardous to human and animal health. Titanium dioxide (TiO2) is primarily used as a whitening agent in paints, plastics, and sunscreens. While relatively inert in its bulk form, nano-TiO2 (diameter) can produce prolonged inflammation and oxidative stress in target tissue. Recently, the potential for nano-TiO2 to cause neuroinflammation and damage has heightened concerns about its continued use. One important concern is that nano-TiO2, and other metal oxide ENMs, may affect fetal neurodevelopment. Accordingly, it is imperative to screen ENMs, like TiO2, for possible neurotoxicity following developmental exposures. The current set of …

Mirror, Mirror In The Chamber: Effects Of Social Stimuli On Operant Behavior, Michael Steele Yencha

Graduate Theses, Dissertations, and Problem Reports (ETD)

The variables affecting social behavior are myriad, making the prediction and control of behavior occurring in social contexts relatively difficult. One can attempt to create a controlled social context in the laboratory by introducing a second organism into an operant chamber. To investigate effects of social stimuli on operant responding, key pecking responses of three pigeons were maintained on a variable-interval (VI) schedule of reinforcement in Experiment 1, and the key pecking responses of three additional pigeons were maintained on a three-component multiple schedule in Experiment 2. The components included a variable-ratio (VR) schedule, a fixed-interval (FI) schedule, and a …

Resilient Stochastic Control Strategies In Cyber-Physical Microgrids, Mohammad Reza Khalghani

Graduate Theses, Dissertations, and Problem Reports (ETD)

Microgrids are the integration of a large number of distributed energy resources in a decentralized way such that the energy supply reliability and resiliency are enhanced against natural disasters, physical and cyber disruptions. This dissertation addresses three main challenges for microgrid operation and management:

1) According to fast growing number of Electric Vehicles (EV) deployment, their impacts on microgrids resulted from their uncertain behaviors are new concerns for the microgrid operators. These concerns can be EV charging and discharging schedule and locations of EV parking-lots in the system which are considered and solved using stochastic modeling and optimization algorithms based …

Cerulean Warbler (Setophaga Cerulea) And Associated Species Response To Operational Silviculture In The Central Appalachian Region, Gretchen Emily Nareff

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this study, I assessed the response of Cerulean Warblers (Setophaga cerulea) and 5 additional songbird species to timber harvests prescribed through operational silviculture. The research took place in relatively contiguous mature deciduous forests in 4 states in the central Appalachian region—Kentucky, Pennsylvania, Virginia, and West Virginia, USA.

For the first part of the study, I collected Cerulean Warbler abundance and territory data through point counts and territory mapping, respectively. I used the point count data to model Cerulean Warbler abundance pre- and post-harvest at 5 study areas (Kentucky [n=1], Virginia [n=2], West Virginia [n=2]) and post-harvest at …

Alternative Splicing In Vertebrate Photoreceptors And Mechanisms Underlying Retinitis Pigmentosa, Jesse C. Sundar

Graduate Theses, Dissertations, and Problem Reports (ETD)

RNA binding proteins (RBPs) have emerged as important regulators of gene expression. RBPs typically contain RNA binding domains that recognize a specific sequence and/or structural motifs within the RNA. This allows them to modulate metabolism of RNAs in several possible ways including regulation of alternative splicing and processing, polyadenylation, translocation, localization, modification, stability, or translation. Previous studies have shown the Musashi (MSI) RBP family to be highly expressed in the retina, and more specifically, photoreceptors, but the importance of this expression remains largely unknown. We identified the MSI proteins as potential regulators of alternative exon splicing in murine photoreceptors. We …

Domain Adaptation And Privileged Information For Visual Recognition, Saeid Motiian

Graduate Theses, Dissertations, and Problem Reports (ETD)

The automatic identification of entities like objects, people or their actions in visual data, such as images or video, has significantly improved, and is now being deployed in access control, social media, online retail, autonomous vehicles, and several other applications. This visual recognition capability leverages supervised learning techniques, which require large amounts of labeled training data from the target distribution representative of the particular task at hand. However, collecting such training data might be expensive, require too much time, or even be impossible. In this work, we introduce several novel approaches aiming at compensating for the lack of target training …

Masthead & Table Of Contents, Vol. 98, No. 1

Nebraska Law Review

No abstract provided.

Masthead & Table Of Contents, Vol. 98, No. 2

Nebraska Law Review

No abstract provided.

Of Providence And Puppet Shows: Divine Hiddenness As Kantian Theodicy, Tyler Paytas

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Kkk In The Pd: White Supremacist Police And What To Do About It, Vida B. Johnson

Lewis & Clark Law Review

There is an epidemic of white supremacists in police departments. Police officers have been identified as members of white supremacist groups in Florida, Alabama and Louisiana. There have been scandals in over 100 different police departments, in over forty different states, in which individual police officers have sent overtly racist emails, texts, or made racist comments via social media. This is a nation-wide problem. It is one that is not limited to just beat officers; some of these shocking occurrences have even involved high-ranking members of their respective police forces. Although the F.B.I. warned of white supremacists infiltrating police departments …

The Transformative Potential Of Digital Media & Technology On Class Actions, Caroline Desmond

Lewis & Clark Law Review

In this Note, the author discusses the true potential that digital media and technology hold for class actions beyond effectuating notice to members of a class. Ironically, just as challenges have mounted against the use of the class action device, digital technology has continued to advance in the background to a point where it may be used to break down barriers to class certification now facing would-be class plaintiffs.

However, much of the current discussion across law reviews and blogs as it relates to digital media and class actions pertains to the effect of digital media on notice. Not only …

A Hybrid Approach To Marijuana Federalism, Susan F. Mandiberg

Lewis & Clark Law Review

With the evident indulgence of the United States Department of Justice, states are jumping on the bandwagon of legalizing medicinal and recreational marijuana even though marijuana use is criminalized under the Federal Controlled Substances Act. The possibility that the federal government will at some point decriminalize marijuana use poses a challenge for the construction of a regulatory framework. In short, how should the states and the federal government divide regulatory responsibilities?

There has been significant academic discussion about possible regulatory frameworks to address this issue. Drawing upon existing federalism schemes in the environmental and natural resource area, this Article reviews …

Safety In Children With Medical Complexity: Our Canaries In The Coal Mine?, Christine A. Schindler, Elisabeth S. Pordes, Steven D. Finkenbinder, K. Jane Lee

College of Nursing Faculty Research and Publications

Purpose of review

The goal of this paper is to describe the complicated and diverse safety risks facing children with medical complexity.

Recent findings

Children with medical complexity have an increased risk of experiencing adverse health outcomes related to multiple comorbidities, the complicated nature of their care, and frequent interactions with the health care system. The safety risks experienced by children with medical complexity are in large part due to the complex nature of their care rather than the specific risks posed by the complicated nature of their illnesses.

Summary

The complicated nature of care for children with medical complexity …

Resting Cerebral Blood Flow After Exercise Training In Mild Cognitive Impairment, Alfonso J. Alfini, Lauren R. Weiss, Kristy A. Nielson, Matthew D. Verber, J. Carson Smith

Psychology Faculty Research and Publications

Background:

Exercise training has been associated with greater cerebral blood flow (CBF) in cognitively normal older adults (CN). Alterations in CBF, including compensatory perfusion in the prefrontal cortex, may facilitate changes to the brain’s neural infrastructure.

Objective:

To examine the effects of a 12-week aerobic exercise intervention on resting CBF and cognition in CN and those with mild cognitive impairment (MCI). We hypothesized individuals with MCI (vs. CN) would exhibit greater whole brain CBF at baseline and that exercise would mitigate these differences. We also expected CBF changes to parallel cognitive improvements.

Methods:

Before and after a 12-week exercise intervention, …

Vertical Sleeve Gastrectomy Improves Ventilatory Drive Through A Leptin-Dependent Mechanism, Deanna M. Arble, Alan R. Schwartz, Vsevolod Y. Polotsky, Darleen A. Sandoval, Randy J. Seeley

Biological Sciences Faculty Research and Publications

Obesity hypoventilation syndrome (OHS) is a serious disorder characterized by daytime hypercapnia, disordered breathing, and a reduction in chemosensitivity. Vertical sleeve gastrectomy (VSG), a bariatric surgical procedure resulting in weight loss and weight-independent improvements in glucose metabolism, has been observed to substantially improve sleep-disordered breathing. However, it is unclear if the ventilatory effects of VSG are secondary to weight loss or the marked change in metabolic physiology. Using preclinical mouse models, we found that VSG leads to an improvement in the hypercapnic ventilatory response (HCVR) and reductions in circulating leptin levels independent of reductions in body mass, fat mass, and …

Occupational Therapy Community Reintegration For Inmates With Co-Occurring Disorders, Miranda Hosking, Kara Moore

Occupational Therapy Capstones

A co-occurring disorder (COD) is the coexistence of a substance use disorder and mental health disorder (Substance Abuse and Mental Health Services Administration, 2016). The prevalence of inmates with COD in correctional facilities is disproportionately high (Grant, Stinson, & Dawson, 2004). Despite the high incidence, correctional facilities are not equipped to meet the complex needs of individuals with COD, which often leads these individuals to re-offending or re-incarceration (Sacks, Chaple, Sacks, McKendrick, & Cleland, 2012). The role of occupational therapy in this area of practice is not clearly distinguished. However, occupational therapy’s holistic, client-centered, and occupation-based principles position the profession …

Occupational Therapy At Stable Days: Supporting A Christian Worldview, Liz Nerhus, Jordan Mooney

Occupational Therapy Capstones

Purpose: The purpose of this project was to provide a framework for use by an occupational therapist providing integrated services from a Christian worldview perspective within a faith-based setting.

Methodology: An extensive literature review was completed on the topics of occupational therapy in integrated faith-based settings, with an emphasis on spirituality, experience of practitioners, current tools of the profession, and the basic tenants of the Christian faith. The search databases used included: CINAHL, OTSEARCH, Pubmed, SocIndex, and PsycINFO. The literature review revealed that nearly 80% of Americans identify spirituality as an important part of their life (Williams-Reade, Lobo and Gutierrez, …

Mechanisms And Immunogenicity Of Nspef-Induced Cell Death In B16f10 Melanoma Tumors, Alessandra Rossi, Olga N. Pakhomova, Andrei G. Pakhomov, Samantha Weygandt, Anna A. Bulysheva, Len E. Murray, Peter A. Mollica, Claudia Muratori

Bioelectrics Publications

Accumulating data indicates that some cancer treatments can restore anticancer immunosurveillance through the induction of tumor immunogenic cell death (ICD). Nanosecond pulsed electric fields (nsPEF) have been shown to efficiently ablate melanoma tumors. In this study we investigated the mechanisms and immunogenicity of nsPEF-induced cell death in B16F10 melanoma tumors. Our data show that in vitro nsPEF (20-200, 200-ns pulses, 7 kV/cm, 2 Hz) caused a rapid dose-dependent cell death which was not accompanied by caspase activation or PARP cleavage. The lack of nsPEF-induced apoptosis was confirmed in vivo in B16F10 tumors. NsPEF also failed to trigger ICD-linked responses such …

Technologies Frequently Used By Elementary Principals, Alejandro Garcia, Jesus Abrego, John Jauregui

Organization and School Leadership Faculty Publications

Technology continues to be a driving force for change in instructional practices. Principals have transitioned from managers to instructional leaders that support innovative technology practices. This study sampled 30 elementary school principals’ technology usage from two school districts and focused on discovering the hardware and software used directly by the elementary principals and how they learned to use those technologies. Data analysis from the online questionnaire and the interviews revealed that the elementary principals used technology predominately for administrative purposes. All the elementary principals surveyed reported that the type of software applications used by them on a daily basis consisted …

Breath Practices For Survivor And Caregiver Stress, Depression, And Post- Traumatic Stress Disorder: Connection, Co-Regulation, Compassion, Patricia L. Gerbarg, Richard P. Brown, Chris C. Streeter, Martin Katzman, Monica Vermani

NYMC Faculty Publications

Does compassion itself benefit the healing process or does the activation of neurophysiological processes, from which the experience of compassion arises, trigger a cascade of physical and psychological changes that support health and well-being? Exploration of the neurological substrates of compassion reveals multiple healing pathways that can be activated by mind-body practices. Furthermore, these pathways affect physical health, emotion regulation, and how we perceive and relate to others.

Physiological states affect the capacity for empathy, compassion and understanding. A state of calm alertness based on sympatho-vagal balance may support such high-level prosocial functions. Evidence suggests that polyvagal-informed mind-body practices, particularly …

Neurological Effects Of Glucocerebrosidase Gene Mutations, S. Mullin, D. Hughes, A. Mehta, A. H.V. Schapira

Peninsula Medical School

No abstract provided.

Perioperative Oxidative Stress: The Unseen Enemy, Jia L. Stevens, Martin Feelisch, Daniel S. Martin

Peninsula Medical School

Reactive oxygen species (ROS) are essential for cellular signaling and physiological function. An imbalance between ROS production and antioxidant protection results in a state of oxidative stress (OS), which is associated with perturbations in reduction/oxidation (redox) regulation, cellular dysfunction, organ failure, and disease. The pathophysiology of OS is closely interlinked with inflammation, mitochondrial dysfunction, and, in the case of surgery, ischemia/reperfusion injury (IRI). Perioperative OS is a complex response that involves patient, surgical, and anesthetic factors. The magnitude of tissue injury inflicted by the surgery affects the degree of OS, and both duration and nature of the anesthetic procedure applied …

Craft Beer And The Rising Tide Effect: An Empirical Study Of Sharing And Collaboration Among Seattle's Craft Breweries, Zahr K. Said

Lewis & Clark Law Review

This qualitative empirical research project studies Seattle’s craft brewing industry as a thriving entrepreneurial ecosystem that displays widespread collaboration and innovation. Drawing on data collected in 22 face-to-face formal interviews conducted with industry participants, the Article explores the community’s attitudes, practices, and norms with respect to collaboration and intellectual property (IP). It joins a growing body of qualitative empirical IP scholarship that maps misalignments between law and practice “on the ground,” seeking to offer a more accurate and pluralistic account of an innovative industry. The craft brewing community in Seattle cooperates extensively while continuing to compete actively for consumers. In …

Harnessing The Gatekeepers Of Glucocorticoids For Chemoprevention Of Non-Melanoma Skin Cancer, Anna M. Mancha-Ramirez, Xiaoyu Yang, Huiyun Liang, Jacob Junco, Kevin P. Lee, Sarah F. Bovio, Maricruz Espinoza, Julia Wool, Dae Joon Kim

School of Medicine Publications

Despite effective surgical methods for non-melanoma skin cancer (NMSC), patients suffer from tissue damage, scarring, or even disfigurement; thus, there is a need for chemopreventive approaches. Because of the complex interplay between glucocorticoids (GCs), inflammation, and cancer, we sought to determine the role of 11β-hydroxysteroid dehydrogenase 1 and 2 (11βHSD1 and 2) in regulating GCs during skin cancer development and progression. 11βHSDs modulate the activation of GCs in a tissue-specific manner and have been reported to play a role in development and progression of other types of cancer, but their role has not yet been reported in NMSC. Here, we …

Healthy Skepticism: The Relationship Between Funding Source And Conclusion In Nutrition-Related Scientific Articles On Saturated Fat, Lili Muskal

CMC Senior Theses

Recently published scientific articles have led to mixed nutritional advice on dietary saturated fatty acids. Lesser et. al (2007) identified that mixed conclusions in scientific articles on sweetened beverages might be attributed industry funding, as articles funded by the beverage industry are four to eight times more likely to report conclusions in favor of the sponsor’s products. This thesis applies Lesser’s methods to determine whether industry funding influences the inconsistent conclusions on saturated fatty acids. This thesis analyzes 100 articles on foods high in dietary saturated fatty acids. While studies with food industry funding are more likely to produce favorable …

The Use Of Personality Testing In Personnel Selection, Riya Kumar

CMC Senior Theses

Research has shown that more than 45% of American companies are opting to integrate personality tests in their recruitment processes. Given this surge in personality testing, this thesis examines whether personality testing is a valid predictor of job-fit and performance in the context of personnel selection. A large proportion of this paper is focused upon the Big-Five factor model, its limitations, and derivative tests of the model. The impact of technology upon personality testing is also discussed as an emerging field. By tracing and examining the history of personality testing to current day, I have found that personality tests are …

The Digitalization Of Development: Understanding The Role Of Technology And Innovation In Development Through A Case Study Of Kenya And M-Pesa, Kara Schachter

CMC Senior Theses

This thesis analyzes the connection of mobile phone technology to increased economic development in Kenya. Drawing on previous research, I first examine the state of development by analyzing social, political, and economic factors in Kenya in 2007/2008. I then examine the role of technology on these development factors in Kenya by focusing on the rapid rise of mobile money platform M-Pesa and the rise of decentralized banking. This thesis finds that M-Pesa’s success stems from the failure of public trust in traditional institutions, collaboration between the public, private, and nonprofit sector, initial lack of regulation to promote innovation, and heavy …

The Changing Nature Of Work, Leadership, And Organizational Culture In Future Ready Organizations, Saloni Dhir

CMC Senior Theses

Abstract

The relationship between individual and organizational performance is a key challenge for leaders in modern organizations, especially with the current disruption in technology and innovation. This thesis is a literature review and compilation of the relevant empirical evidence on various processes of industrial groups and organizational characteristics such as the changing nature of work, leadership, and company culture in detail. I investigate the complex challenges that millennials and organizations are facing in the current VUCA work environment as well as their potential responses to these changes. I map out the evolution of the concept of work and compare changes …

The Rhesus Macaque Corticospinal Connectome, Sydney Talmi

CMC Senior Theses

The corticospinal tract (CST), which carries commands from the cerebral cortex to the spinal cord, is vital to fine motor control. Spinal cord injury (SCI) often damages CST axons, causing loss of motor function, most notably in the hands and legs. Our preliminary work in rats suggests that CST circuitry is complex: neurons whose axons project to the lower cervical spinal cord, which directly controls hand function, also send axon collaterals to other locations in the nervous system and may engage parallel motor systems. To inform research into repair of SCI, we therefore aimed to map the entire projection pattern, …