Digital Commons Network^™

Farm Animals Are Not Humans In Sheep Clothing, Lorenz Gygax, Christian Nawroth

Animal Sentience

Research on the mental lives of farm animals is crucial to assess not only their physical but also their psychological wellbeing. Their current housing and handling practices are highly unlikely to meet their cognitive needs and demands, but our knowledge of their mental capacities is still limited. Although folk wisdom often refers to farm animals as dull and inflexible, recent studies show they have a rich interpretation of their environment and can solve complex problems. Yet an uncritical and anthropomorphic assessment of farm animal cognition and behaviour may lead to the attribution of an exaggerated amount of cognitive flexibility. Contrary …

The Importance Of Research Applicability, Krista Mclennan

Animal Sentience

Marino & Merskin’s (2019) review contains key information about the complexity of sheep and their intelligence level, but lacks practical application. The key to making any long-term changes to sheep welfare at an industry level is by generating research that is practically relevant to the sector. The practical application of research should be considered at the design stage and in consultation with producers. Additionally, thought needs to be given to how the practical application of the research will be transferred to those people directly involved in animal care (e.g., producers, stockpersons, etc.). Focusing on the practical relevance and application of …

To Preserve Or To Conserve?, Liv Baker

Animal Sentience

Treves et al. propose the notion of trusteeship to help meet our responsibility to nature and individual animals, their homes, cultures, and societies. This proposal is grounded in a real-world framework that reveals how conservation has become distorted by anthropocentrism, human exceptionalism, and ethical hypocrisy.

Asking The Right Question: The Statutory Right Of Appraisal And Efficient Markets, Jonathan Macey, Joshua Mitts

Faculty Scholarship

In this article, we make several contributions to the literature on appraisal rights and cases in which courts assign values to a company's shares in the litigation context. First, we applaud the recent trend in Delaware cases to consider the market prices of the stock of the company being valued if that stock trades in an efficient market, and we defend this market-oriented methodology against claims that recent discoveries in behavioral finance indicate that share prices are unreliable due to various cognitive biases. Next, we propose that the framework and methodology for utilizing market prices be clarified. We maintain that …

Sovereignty And Complex Interdependence: Some Surprising Indications Of Their Compatibility, Charles F. Sabel

Faculty Scholarship

Even as democratic sovereignty and globalization are increasingly seen as incompatible in theory, this chapter argues that, in some important realms, they are proving compatible in practice. As tariffs have fallen to negligible levels, trade agreements among rich countries have come to focus on reconciling regulatory differences. In many sectors, novel forms of cooperation have emerged that allow trade partners deliberately to investigate and learn from one another’s practices, eventually recognizing the equivalence of regimes that are not strictly identical — and in the process extending domestic political oversight to relations among states while often heightening domestic accountability. The emergent …

Police Contact And The Legal Socialization Of Urban Teens, Jeffrey A. Fagan, Amanda Geller

Faculty Scholarship

Contemporary American policing has routinized involuntary police contacts with young people through frequent, sometimes intrusive investigative stops. Personal experience with the police has the potential to corrode adolescents’ relationships with law and skew law-related behaviors. We use the Fragile Families and Child Wellbeing Study to estimate how adolescents’ experiences with the police shape their legal socialization. We find that both personal and vicarious police contact are associated with increased legal cynicism. Associations are present across racial groups and are not explained by teens’ behaviors, school settings, or family backgrounds. Legal cynicism is amplified in teens reporting intrusive contact but diminished …

Embodied Healthcare Intuition: A Taxonomy Of Sensory Cues Used By Healthcare Providers, Lillian Campbell, Elizabeth L. Angeli

English Faculty Research and Publications

Although healthcare providers’ decision-making is informed by data and proto­cols for care, recent research suggests that individuals’ intuition—which integrates previous experiences with situational awareness and sensory knowledge—also plays a large role in directing action. Drawing on two different datasets from research on EMS providers and nurses in clinical nursing simulations, this article intro­duces a taxonomy for the various cues that trigger intuitive action and unpacks how intuition manifests at different stages of care. We argue that healthcare providers rhetorically navigate a wide range of both external and internal intuitive cues, and that external cues draw on sensory engagement with bodies, …

[The Inaugural Issue (2019)], University Of Montana--Missoula. School Of Journalism

Byline

It happened to #MeToo -- Becoming a Dreamer -- Halfway Home -- College in an Education Desert -- On the Line: Wildland firefighters learn to survive in the era of megafires -- At the Crossroads: Violence behind the bars of Montana's only private prison -- Return of the Buffalo -- Life Is Harder Than Combat -- Dealing with Drift: Montana's organic farmers face limited options for compensation

The Promising Viral Threat To Bacterial Resistance: The Uncertain Patentability Of Phage Therapeutics And The Necessity Of Alternative Incentives, Kelly Todd

Duke Law Journal

Bacteriophages, or “phages,” are a category of highly adept and adaptable viruses that can infect and kill bacteria. With concerns over the burgeoning antibiotic-resistance crisis looming in recent years, scientists and policymakers have expressed a growing interest in developing novel treatments for bacterial infections that utilize bacteriophages. Because of the great expense associated with bringing a new drug to market, patents are usually considered the gold standard for incentivizing research and development in the pharmaceutical field. Absent such strong protection for a developer’s front end investment, pharmaceutical development remains financially risky and unattractive. Unfortunately, recent Supreme Court jurisprudence analyzing patentable …

Never Seen Before--Again: Aesthetic Adaptation And Transmedia Storytelling Networks In The Age Of Digital Cinema, Mike Mccleary

Theses and Dissertations (Comprehensive)

The primary purpose of this study is to re-evaluate the theorization of the narrative/non-narrative divide in cinema because there is still far too much rich information that is being lost in the chasm left between these two positions, particularly when it comes to the study of spectacular imagery. Working beyond the binary construction of a narrative/non-narrative divide allows for a more nuanced and dynamic analysis of the information that is conveyed by the cinematic image and, more specifically, by way of its aesthetic design. By no means is this study championing image over story or any other such formulation; rather …

Factors Influencing Zooplankton Communities In Small Arctic Lakes, Northwest Territories, Jasmina Vucic

Theses and Dissertations (Comprehensive)

The Canadian Arctic has been warming at an unprecedented rate, causing significant changes to the environment. At the same time, continued development in the north has increased the demand for gravel extraction used to construct and maintain infrastructure such as highways. The development of roadways and gradual loss of permafrost in Canada’s north has led to changes in water quality, including increased calcium, conductivity, and nutrients. In addition, gravel extraction has led to the formation of artificial gravel pit lakes. Research has yet to determine how physical and chemical changes associated with development and permafrost thaw might impact zooplankton, and …

Helping Those Who Are Like Me: Highlighting Similarities To Elicit Empathy In Narcissists, Alys Yijun Zhao, Christian H. Jordan

Theses and Dissertations (Comprehensive)

Previous research suggests that narcissists (compared to less narcissistic individuals) lack empathy toward others unless specifically instructed to take others’ perspectives. But are narcissists capable of spontaneously empathizing with others without the need for instructed perspective-taking? Three studies addressed this question. Study 1 (Study 1a; N = 232 & Study 1b; N = 488) examined whether manipulating a target person’s level of narcissism (i.e., non-narcissistic, moderately-narcissistic, or highly-narcissistic) encouraged more empathy toward more narcissistic targets, who described a difficult romantic breakup, from more narcissistic participants. Study 2 (N = 590) used the same procedure and further examined whether target …

The Architecture Of Property, Thomas W. Merrill, Henry E. Smith

Faculty Scholarship

Avoiding the reduction of property to a bundle or rights or to the working out of a single master principle, the architectural theory of property sees property as an integrated system or structure anchored in certain unifying principles. Because our world is neither chaotic nor additiviely simple, property law and institutions must achieve their plural ends in a fashion that manages the inherent complexity of the interaction of valued resource attributes and human actions. In managing complexity, some of the law’s structures receive functional explanations and justifications, which can be different from the explanations and justifications that apply to the …

Freedom, Choice, And Contracts, Hanoch Dagan, Michael A. Heller

Faculty Scholarship

In “The Choice Theory of Contracts,” we explain contractual freedom and celebrate the plurality of contract types. Here, we reply to critics by refining choice theory and showing how it fits and shapes what we term the “Contract Canon”.

I. Freedom. (1) Charles Fried challenges our account of Kantian autonomy, but his views, we show, largely converge with choice theory. (2) Nathan Oman argues for a commerce-enhancing account of autonomy. We counter that he arbitrarily slights noncommercial spheres central to human interaction. (3) Yitzhak Benbaji suggests that choice theory’s commitment to autonomy is overly perfectionist. Happily, in response to Benbaji, …

Law's Halo And The Moral Machine, Bert I. Huang

Faculty Scholarship

How will we assess the morality of decisions made by artificial intelli­gence – and will our judgments be swayed by what the law says? Focusing on a moral dilemma in which a driverless car chooses to sacrifice its passenger to save more people, this study offers evidence that our moral intuitions can be influenced by the presence of the law.

Domesticating Guidance, Peter L. Strauss

Faculty Scholarship

This Essay, written for an occasion celebrating the scholarship of Professor William Funk of Lewis & Clark Law School, builds in good part on his analyses of soft law documents — statements of general policy and interpretive rules — that today one generally finds discussed under the rubric “guidance.” These are agency texts of less formality than hard law regulations adopted under the procedures of 5 U.S.C. § 553, that inform the public how an agency intends to administer its responsibilities, as a matter of policy or (what may seem just one instance of that) via the interpretation of its …

Separation Of Powers In Comparative Perspective: How Much Protection For The Rule Of Law?, Peter L. Strauss

Faculty Scholarship

This chapter discusses the separation of powers. The point about traditions, or shared social norms, is a central one for this chapter. At a time of growing pessimism about the fate of democracy worldwide, adherence to norms of political behaviour may have an importance transcending formal provisions for the allocation of governmental power. As such, this chapter first presents a brief account of ‘separation of powers’ under American presidentialism; then the contrasting system of Westminster parliamentarianism; third, the increasingly prevalent mixed regimes, often semi-presidential, that can be described as ‘constrained parliamentarism’; and, finally, international institutions. As the chapter shows, in …

Eroding "Checks" On Presidential Authority – Norms, The Civil Service, And The Courts, Peter L. Strauss

Faculty Scholarship

Susan Rose-Ackerman's "Executive Rulemaking and Democratic Legitimacy: 'Reform' in the United States and the United Kingdom's Route to Brexit" insightfully illuminates important differences between parliamentary and presidential systems of government in relation to executive bodies' production of the large volume of secondary legislation common, indeed inevitable, for both. Agreeing heartily with her conclusion that the weakness of parliamentary engagement with secondary legislation, and limited judicial review of its production, counsels greater provision for public participation and transparency of action at the agency level, there is little for me to add. Aware, too, as she remarks, that others have dealt more …

An Intersectional Critique Of Tiers Of Scrutiny: Beyond “Either/Or” Approaches To Equal Protection, Devon W. Carbado, Kimberlé W. Crenshaw

Faculty Scholarship

For the past forty years, Justice Powell’s concurring opinion in University of California v. Bakke has been at the center of scholarly debates about affirmative action. Notwithstanding the enormous attention Justice Powell’s concurrence has received, scholars have paid little attention to a passage in that opinion that expressly takes up the issue of gender. Drawing on the theory of intersectionality, this Essay explains several ways in which its reasoning is flawed. The Essay also shows how interrogating Justice Powell’s “single axis” race and gender analysis raises broader questions about tiers of scrutiny for Black women. Through a hypothetical of a …

Speech And Exercise By Private Individuals And Organizations, Kent Greenawalt

Faculty Scholarship

A central issue about redundancy concerns how far the exercise of religion is simply a form of speech that is, and should be, constitutionally protected only to the extent that reaches speech generally. Insofar as a constitutional analysis leaves flexibility, we have questions about wise legislative choices. To consider these issues carefully, we need to have a sense of what counts as relevant speech and the exercise of religion. That is the focus of this article.

It addresses the basic categorization of what counts as “speech” for freedom of speech and what counts as religious exercise when each is engaged …

Jurisdiction Stripping Circa 2020: What The Dialogue (Still) Has To Teach Us, Henry P. Monaghan

Faculty Scholarship

Since its publication in 1953, Henry Hart’s famous article, The Power of Congress to Limit the Jurisdiction of Federal Courts: An Exercise in Dialectic, subsequently referred to as simply “The Dialogue,” has served as the leading scholarly treatment of congressional control over the federal courts. Now in its seventh decade, much has changed since Hart first wrote. This Article examines what lessons The Dialogue still holds for its readers circa 2020.

On Posner On Copyright, Tim Wu

Faculty Scholarship

The judiciary are different than you and me, not just because they have life tenure, but because they spend years being petitioned by real people. A judge therefore does not face problems as a logistician or an academic does but instead faces a demand to do something for someone, based on events preceding. The resulting posture of decision tends to bring something out, something Justice Oliver Wendell Holmes once described as “the secret root from which the law draws all the juices of life.”

We can learn more about this “secret root” of the common law decision-making from Richard Posner’s …

Camas, Winter 2019

Camas

Crossings / Kitty Galloway -- The Scavenger / Dov Weinman -- Winter / Bryce Peterson -- Back to the Mud / Chris La Tray -- Volumes / Natalie Storey -- On Speaking Terms / B.A. Van Sise -- Mise en Abyme / Eliza Marley -- Plague Garden / Chad Foret -- Awaiting Burial / Kersten Christianson -- Maurauders All / Jan Harris -- Currant Bushes Speaking From November / Tara K. Shepersky -- Lower Forms of Life / Gary Beaumier -- The Pileated Woodpecker / John Noland

What Is In An Octopus's Mind?, Jennifer Mather

Animal Sentience

It is difficult to imagine what an animal as different from us as the octopus ‘thinks’, but we can make some progress. In the Umwelt or perceptual world of an octopus, what the lateralized monocular eyes perceive is not color but the plane of polarization of light. Information is processed by a bilateral brain but manipulation is done by a radially symmetrical set of eight arms. Octopuses do not self-monitor by vision. Their skin pattern system, used for excellent camouflage, is open loop. The output of the motor system of the eight arms is organized at several levels — brain, …

‘Mind’ Is An Ill-Defined Concept: Considerations For Future Cephalopod Research, Alexandra Schnell, Giorgio Vallortigara

Animal Sentience

Scientific discussions about the ‘mind’ of an octopus are empirically vacuous and should be confined to folk psychology. This form of labelling is unhelpful for science and should be replaced by specific mechanistic accounts of behavior and associated neural structures, which are amenable to rigorous scientific investigation. Mather provides a detailed review of octopus behavior, but rather than making unquantifiable assumptions about what orchestrates octopus behavior, efforts should focus on investigating cognitive mechanisms that can be measured. In this commentary, we outline two lines of research that include quantifiable methods to facilitate a more robust understanding of cephalopod behaviors and …

Mitochondrial Superoxide Disrupts The Metabolic And Epigenetic Landscape Of Cd4, Cassandra M. Moshfegh, Christopher W. Collins, Venugopal Gunda, A. Vasanthakumar, J. Z. Cao, Pankaj K. Singh, L. A. Godley, Adam J. Case

Journal Articles: Eppley Institute

While the role of mitochondrial metabolism in controlling T-lymphocyte activation and function is becoming more clear, the specifics of how mitochondrial redox signaling contributes to T-lymphocyte regulation remains elusive. Here, we examined the global effects of elevated mitochondrial superoxide (O₂^-) on T-lymphocyte activation using a novel model of inducible manganese superoxide dismutase (MnSOD) knock-out. Loss of MnSOD led to specific increases in mitochondrial O₂^- with no evident changes in hydrogen peroxide (H₂O₂), peroxynitrite (ONOO^-), or copper/zinc superoxide dismutase (CuZnSOD) levels. Unexpectedly, both mitochondrial and glycolytic metabolism showed significant reductions …

Fascin Controls Metastatic Colonization And Mitochondrial Oxidative Phosphorylation By Remodeling Mitochondrial Actin Filaments, Shengchen Lin, Chongbiao Huang, Venugopal Gunda, Jianwei Sun, Srikumar P. Chellappan, Zengxun Li, Victoria Izumi, Bin Fang, John Koomen, Pankaj K. Singh, Jihui Hao, Shengyu Yang

Journal Articles: Eppley Institute

The deregulation of the actin cytoskeleton has been extensively studied in metastatic dissemination. However, the post-dissemination role of the actin cytoskeleton dysregulation is poorly understood. Here, we report that fascin, an actin-bundling protein, promotes lung cancer metastatic colonization by augmenting metabolic stress resistance and mitochondrial oxidative phosphorylation (OXPHOS). Fascin is directly recruited to mitochondria under metabolic stress to stabilize mitochondrial actin filaments (mtF-actin). Using unbiased metabolomics and proteomics approaches, we discovered that fascin-mediated mtF-actin remodeling promotes mitochondrial OXPHOS by increasing the biogenesis of respiratory Complex I. Mechanistically, fascin and mtF-actin control the homeostasis of mtDNA to promote mitochondrial OXPHOS. The …

Metabolic Alterations In Pancreatic Cancer Progression, Enza Vernucci, Jaime Abrego, Venugopal Gunda, Surendra K. Shukla, Aneesha Dasgupta, Vikrant Rai, Nina V. Chaika, Kyla Buettner, Alysha Illies, Fang Yu, Audrey J. Lazenby, Benjamin J. Swanson, Pankaj K. Singh

Journal Articles: Eppley Institute

Pancreatic cancer is the third leading cause of cancer-related deaths in the USA. Pancreatic tumors are characterized by enhanced glycolytic metabolism promoted by a hypoxic tumor microenvironment and a resultant acidic milieu. The metabolic reprogramming allows cancer cells to survive hostile microenvironments. Through the analysis of the principal metabolic pathways, we identified the specific metabolites that are altered during pancreatic cancer progression in the spontaneous progression (KPC) mouse model. Genetically engineered mice exhibited metabolic alterations during PanINs formation, even before the tumor development. To account for other cells in the tumor microenvironment and to focus on metabolic adaptations concerning tumorigenic …

The Mitochondrial Deoxyguanosine Kinase Is Required For Cancer Cell Stemness In Lung Adenocarcinoma, Shengchen Lin, Chongbiao Huang, Jianwei Sun, Oana Bollt, Xiuchao Wang, Eric Martine, Jiaxin Kang, Matthew D. Taylor, Bin Fang, Pankaj K. Singh, John Koomen, Jihui Hao, Shengyu Yang

Journal Articles: Eppley Institute

The mitochondrial deoxynucleotide triphosphate (dNTP) is maintained by the mitochondrial deoxynucleoside salvage pathway and dedicated for the mtDNA homeostasis, and the mitochondrial deoxyguanosine kinase (DGUOK) is a rate-limiting enzyme in this pathway. Here, we investigated the role of the DGUOK in the self-renewal of lung cancer stem-like cells (CSC). Our data support that DGUOK overexpression strongly correlates with cancer progression and patient survival. The depletion of DGUOK robustly inhibited lung adenocarcinoma tumor growth, metastasis, and CSC self-renewal. Mechanistically, DGUOK is required for the biogenesis of respiratory complex I and mitochondrial OXPHOS, which in turn regulates CSC self-renewal through AMPK-YAP1 signaling. …

Inhibition Of Geranylgeranyl Diphosphate Synthase Is A Novel Therapeutic Strategy For Pancreatic Ductal Adenocarcinoma, Staci L. Haney, Michelle L. Varney, Yashpal S. Chhonker, Simon Shin, Kamiya Mehla, Ayrianne J. Crawford, Heather Jensen Smith, Lynette M. Smith, Daryl J. Murry, Michael A. Hollingsworth, Sarah A. Holstein

Journal Articles: Eppley Institute

Rab proteins play an essential role in regulating intracellular membrane trafficking processes. Rab activity is dependent upon geranylgeranylation, a post-translational modification that involves the addition of 20-carbon isoprenoid chains via the enzyme geranylgeranyl transferase (GGTase) II. We have focused on the development of inhibitors against geranylgeranyl diphosphate synthase (GGDPS), which generates the isoprenoid donor (GGPP), as anti-Rab agents. Pancreatic ductal adenocarcinoma (PDAC) is characterized by abnormal mucin production and these mucins play important roles in tumor development, metastasis and chemo-resistance. We hypothesized that GGDPS inhibitor (GGDPSi) treatment would induce PDAC cell death by disrupting mucin trafficking, thereby inducing the unfolded …