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2019

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A New Species Of Tortanus (Atortus) (Copepoda, Calanoida, Tortanidae) From Minicoy Island, Southeastern Arabian Sea, Sanu Vengasseril Francis, Sivasankaran Bijoy Nandan Jan 2019

A New Species Of Tortanus (Atortus) (Copepoda, Calanoida, Tortanidae) From Minicoy Island, Southeastern Arabian Sea, Sanu Vengasseril Francis, Sivasankaran Bijoy Nandan

Turkish Journal of Zoology

A new species of the planktonic calanoid copepod genus Tortanus, subgenus Atortus, is described from a coral reef lagoon of Minicoy Island, southeastern Arabian Sea. The new species is included in the tropicus group, which is mainly distributed in the tropical and subtropical waters of Southeast Asia. The species can be distinguished from all other species of the tropicus group by the asymmetrical fifth pedigerous somite with notched left margin and triangular lobe in the right, hyaline coupling device with larger left process, 2 ventrolateral spines in the genital compound somite, and caudal rami with 2 medial rounded processes in …

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Morphological, Ultrastructural, And Molecular Identification Of A New Microsporidian Pathogen Isolated From Crepidodera Aurata (Coleoptera, Chrysomelidae), Mustafa Yaman, Gönül Algi, Renate Radek Jan 2019

Morphological, Ultrastructural, And Molecular Identification Of A New Microsporidian Pathogen Isolated From Crepidodera Aurata (Coleoptera, Chrysomelidae), Mustafa Yaman, Gönül Algi, Renate Radek

Turkish Journal of Zoology

A new microsporidian pathogen isolated from Crepidodera aurata was identified based on morphological and ultrastructural characteristics, coupled with a molecular phylogenetic analysis. The spores of the microsporidian pathogen were slightly curved in shape, and measured 2.44-3.55 µm in length and 1.25-1.55 µm in width (n = 50). Its ultrastructure is characteristic of monokaryotic groups. All lifecycle stages of the pathogen, including meronts, sporonts, sporoblasts, and mature spores, are monokaryotic. The spore has 6-8 windings of the polar filament. Morphological and ultrastructural characteristics of the lifecycle stages place it within the family Unikaryonidae. However, the phylogenetic tree constructed on the 16S …

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Structure Of Molluscan Communities In Shallow Subtidal Rocky Bottoms Of Acapulco, Mexico, José Gabriel Kuk Dzul, Jesús Guadalupe Padilla Serrato, Carmina Torreblanca Ramirez, Rafael Flores Garza, Pedro Flores Rodríguez, Ximena Itzamara Muñiz Sánchez Jan 2019

Structure Of Molluscan Communities In Shallow Subtidal Rocky Bottoms Of Acapulco, Mexico, José Gabriel Kuk Dzul, Jesús Guadalupe Padilla Serrato, Carmina Torreblanca Ramirez, Rafael Flores Garza, Pedro Flores Rodríguez, Ximena Itzamara Muñiz Sánchez

Turkish Journal of Zoology

The objective of this study was to determine the structure of molluscan communities in shallow subtidal rocky bottoms of Acapulco, Mexico. Thirteen samplings were performed at 8 stations in 2012 (seven samplings), 2014 (four), and 2015 (two). The collection of the mollusks in each station was done at a maximum depth of 5 m for 1 h by 3 divers. A total of 2086 specimens belonging to 89 species, 36 families, and 3 classes of mollusks were identified. Gastropoda was the most diverse and abundant group. Calyptreaidae, Columbellidae, and Muricidae had >5 species, but Pisaniidae, Conidae, Fasciolariidae, and Muricidae had …

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Detailed Analysis Of Beluga Sturgeon (Huso Huso) And Stellate Sturgeon(Acipenser Stellatus) Migration In The Lower Danube River, Stefan Hont, Marian Paraschiv, Marian Ion Iani, Elena Taflan, Daniela Nicoleta Holostenco, Delia Oprea, Lucian Oprea Jan 2019

Detailed Analysis Of Beluga Sturgeon (Huso Huso) And Stellate Sturgeon(Acipenser Stellatus) Migration In The Lower Danube River, Stefan Hont, Marian Paraschiv, Marian Ion Iani, Elena Taflan, Daniela Nicoleta Holostenco, Delia Oprea, Lucian Oprea

Turkish Journal of Zoology

The swimming ground speed and swimming depths of beluga sturgeon (Huso huso) and stellate sturgeon (Acipenser stellatus) were investigated using ultrasonic telemetry between 2011 and 2017 in the Lower Danube River (river kilometer (rkm) 0 Sulina-rkm 1075 Baziaş). Acoustic telemetry receivers VR2W and V16TP tags (Vemco, Canada) were used to collect data about sturgeon migration behavior in the Lower Danube River between the Black Sea and the Iron Gate II dam. The tags, equipped with depth and temperature sensors, provided data about beluga and stellate sturgeon migration periods, swimming speeds, and depths. Twenty-three beluga sturgeon (184-245 cm TL) and twenty-one …

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Comparative Evaluation Of Taxonomic And Functional Diversities Of Leaf-Litter Ants Of The Brazilian Atlantic Forest, Elmo Borges De Azevedo Koch, José Raimundo Maia Dos Santos, Ivan Cardoso Nascimento, Jacques Hubert Charles Delabie Jan 2019

Comparative Evaluation Of Taxonomic And Functional Diversities Of Leaf-Litter Ants Of The Brazilian Atlantic Forest, Elmo Borges De Azevedo Koch, José Raimundo Maia Dos Santos, Ivan Cardoso Nascimento, Jacques Hubert Charles Delabie

Turkish Journal of Zoology

The ant community living in leaf litter was assessed in 65 forest sites in the Brazilian Atlantic rainforest in the southern region of the state of Bahia, Brazil. In addition, we aimed to understand the patterns between taxonomic and functional diversities using two different resolutions of classification of ants into functional groups. We identified 364 ant species belonging to 68 genera in 10 subfamilies in 65 regions. Considering a more general functional classification, we identified a total of 13 functional ant groups, and 26 functional ant groups considering a more specific functional classification. The Atlantic Forest environments studied presented great …

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Spatial Distribution Of The Epigeic Species Of Earthworms Dendrobaena Octaedra And D. Attemsi (Oligochaeta: Lumbricidae) In The Forest Belt Of The Northwestern Caucasus, Anna Geraskina, Nicolai Shevchenko Jan 2019

Spatial Distribution Of The Epigeic Species Of Earthworms Dendrobaena Octaedra And D. Attemsi (Oligochaeta: Lumbricidae) In The Forest Belt Of The Northwestern Caucasus, Anna Geraskina, Nicolai Shevchenko

Turkish Journal of Zoology

Evaluation of the spatial distribution of 2 ecologically similar, but different, in terms of their spatial ranges, earthworm species, D. octaedra and D. attemsi, in the belt forests of northwestern Caucasus were based on our own natural data and using geographic information system (GIS) modeling of modern potential distributions. The quantitative records of earthworms were collected in beech, deciduous, dark coniferous, coniferous-deciduous, and pine forests (1028 geographic locations). Of the most important microsites inhabited by the epigeic earthworms, 2 (plant litter and deadwood) were examined. It was demonstrated that there was high correlation of the 2 species with the humidity …

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Spatiotemporal Patterns Of Ground Beetle Diversity (Coleoptera: Carabidae) In A Ramsar Wetland (Chott Tinsilt) Of Algeria, Cherine Amri, Souad Neffar, Nadia Ouchtati, Haroun Chenchouni Jan 2019

Spatiotemporal Patterns Of Ground Beetle Diversity (Coleoptera: Carabidae) In A Ramsar Wetland (Chott Tinsilt) Of Algeria, Cherine Amri, Souad Neffar, Nadia Ouchtati, Haroun Chenchouni

Turkish Journal of Zoology

The aim of this study was to investigate the biodiversity and structure of the Carabidae community living at the edges of a Ramsar wetland in northeastern Algeria, as well as to analyze the effect of environmental variables on this Carabidae community. The study site included two stations (T1, T2). From November 2016 to October 2017, the carabidofauna was sampled fortnightly using pitfall traps. The structure and diversity of the beetle community were measured using nonparametric indices, i.e. species richness, diversity indices, accumulation curves, and similarity analysis. Generalized linear mixed effects models (GLMM) were applied to examine the spatiotemporal variation of …

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Siberigondolella Gen. Nov., A Boreal Early Triassic Lanceolate Conodont, Ali̇ Murat Kiliç, Francis Hirsch Jan 2019

Siberigondolella Gen. Nov., A Boreal Early Triassic Lanceolate Conodont, Ali̇ Murat Kiliç, Francis Hirsch

Turkish Journal of Zoology

In the Lower Triassic, at the time that segminate gondolellid conodonts defined the Tethyan regions, endemic segminiplanate gondolellid conodonts resembling the genus ?Neogondolella? dwelled in the northern latitudes. Without the multielement apparatus characteristic of the subfamily Neogondolellinae, these forms are phylogenetically incertae sedis and one lineage was attributed to the genus Siberigondolella gen. nov.

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Molecular Identification Of Invasive Drosophilid Zaprionus Tuberculatus Malloch (Diptera: Drosophilidae) In Çanakkale, Turkey, Akin Kuyulu, Seda Yücel, Hani̇fe Genç Jan 2019

Molecular Identification Of Invasive Drosophilid Zaprionus Tuberculatus Malloch (Diptera: Drosophilidae) In Çanakkale, Turkey, Akin Kuyulu, Seda Yücel, Hani̇fe Genç

Turkish Journal of Zoology

The vinegar or pomace fly, Zaprionus tuberculatus Malloch, is native to the Afrotropical region but has recently colonized new areas in Turkey, Italy, Malta, Romania, and Greece. This invasive species was first detected in 2012 in Adana on banana and peach baits and is considered a potential agricultural pest in fig production in Turkey. However, the European and Mediterranean Plant Organization reports that no direct association of the fly with fruit damage has been documented so far because specimens were generally caught in traps. Specimens of Zaprionus sp. were monitored during surveys for cases of Drosophila suzukii (Matsumura) and Ceratitis …

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Cover And Contents Jan 2019

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

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Modulation Of Pten By Hexarelin Attenuates Coronary Artery Ligation-Induced Heart Failure In Rats, Elvis Agbo, Donghai Liu, Meixiu Li, Roland Osei Saahene, Liqiang Chen, Junpeng Zhao, Yiquan Wang, Guozhong Tian Jan 2019

Modulation Of Pten By Hexarelin Attenuates Coronary Artery Ligation-Induced Heart Failure In Rats, Elvis Agbo, Donghai Liu, Meixiu Li, Roland Osei Saahene, Liqiang Chen, Junpeng Zhao, Yiquan Wang, Guozhong Tian

Turkish Journal of Medical Sciences

Background/aim: Hexarelin is a synthetic growth hormone-releasing peptide that exerts cardioprotective effects. However, its cardioprotective effect against heart failure (HF) is yet to be explained. This study investigated the therapeutic role of hexarelin and the mechanisms underlying its cardioprotective effects against coronary artery ligation (CAL)-induced HF in rats. Materials and methods: Rats with four weeks of permanent CAL, induced myocardial infarction, and HF were randomly separated into four groups: the control group (Ctrl), sham group (Sham), hexarelin treatment group (HF + Hx), and heart failure group (HF). The rats were treated with subcutaneous injection of hexarelin (100 μg/kg) in the …

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Childhood Atopic Dermatitis: Current Developments, Treatment Approaches, And Future Expectations, Pinar Gür Çeti̇nkaya, Ümi̇t Murat Şahi̇ner Jan 2019

Childhood Atopic Dermatitis: Current Developments, Treatment Approaches, And Future Expectations, Pinar Gür Çeti̇nkaya, Ümi̇t Murat Şahi̇ner

Turkish Journal of Medical Sciences

Atopic dermatitis (AD) is the most common chronic inflammatory skin disorder of childhood. Underlying factors that contribute to AD are impaired epithelial barrier, alterations in the lipid composition of the skin, immunological imbalance including increased Th2/Th1 ratio, proinflammatory cytokines, decreased T regulatory cells, genetic mutations, and epigenetic alterations. Atopic dermatitis is a multifactorial disease with a particularly complicated pathophysiology. Discoveries to date may be considered the tip of the iceberg, and the increasing number of studies in this field indicate that there are many points to be elucidated in AD pathophysiology. In this review, we aimed to illustrate the current …

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Mesh Nebulizer Is As Effective As Jet Nebulizer In Clinical Practice Of Acute Asthma In Children, Özge Uysal Soyer, Meli̇ke Kahveci̇, Ayşe Betül Büyükti̇ryaki̇, Ebru Arik Yilmaz, Betül Karaatmaca, Sali̇ha Esenboğa, Pinar Gür Çeti̇nkaya, Ümi̇t Murat Şahi̇ner, Bülent Eni̇s Şekerel Jan 2019

Mesh Nebulizer Is As Effective As Jet Nebulizer In Clinical Practice Of Acute Asthma In Children, Özge Uysal Soyer, Meli̇ke Kahveci̇, Ayşe Betül Büyükti̇ryaki̇, Ebru Arik Yilmaz, Betül Karaatmaca, Sali̇ha Esenboğa, Pinar Gür Çeti̇nkaya, Ümi̇t Murat Şahi̇ner, Bülent Eni̇s Şekerel

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to compare the effect of salbutamol delivered to children by jet nebulizer (JN) and mesh nebulizer (MN). Materials and methods: Children admitted with acute asthma were treated with 3 doses of nebulized salbutamol, 1 given by MN. The patients' vital signs, lung function measurements, modified pulmonary index score (MPIS), and whole body plethysmography (WBP) measurements were evaluated before and 20 min after each dose of salbutamol.Results: Thirty-onechildren [9.5 (6.4-17.2) years, 67.7% male, 32.3% female] with mild (67.7%) and moderate (32.3%) asthma attacks were included in the study. The improvements with MN were comparable …

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Efficiency Of Pulsed Electromagnetic Fields On Pain, Disability, Anxiety, Depression, And Quality Of Life In Patients With Cervical Disc Herniation: A Randomized Controlled Study, Erkam Hattapoğlu, İbrahi̇m Batmaz, Banu Di̇lek, Mehmet Karakoç, Serda Em, Remzi̇ Çevi̇k Jan 2019

Efficiency Of Pulsed Electromagnetic Fields On Pain, Disability, Anxiety, Depression, And Quality Of Life In Patients With Cervical Disc Herniation: A Randomized Controlled Study, Erkam Hattapoğlu, İbrahi̇m Batmaz, Banu Di̇lek, Mehmet Karakoç, Serda Em, Remzi̇ Çevi̇k

Turkish Journal of Medical Sciences

Background/aim: In this study, it was aimed to investigate the effects ofpulsed electromagnetic field(PEMF) therapy on pain, disability, psychological state, and quality of life in cervical disc herniation.Materials and methods: Patients were randomly divided into two groups, including Group 1, which received a therapy consisting of transcutaneous electrical nerve stimulation (TENS), hot pack (HP), and PEMF, and Group 2, which received a magnetic field (sham magnetic field) without current flow in addition to TENS and HP therapy. Pain was assessed by a visual analog scale (VAS, 0?10 cm). The other outcome measures were function (Neck Pain and Disability Scale), anxiety-depressive …

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The Relationship With Clinical Course And Prognosis Of Serum Endothelin-1, Angiopoietin-2, And Tie-2 Levels In Crimean-Congo Hemorrhagic Fever, Ferhan Kerget, Zülal Özkurt, Nuri̇nni̇sa Öztürk, Si̇nan Yilmaz Jan 2019

The Relationship With Clinical Course And Prognosis Of Serum Endothelin-1, Angiopoietin-2, And Tie-2 Levels In Crimean-Congo Hemorrhagic Fever, Ferhan Kerget, Zülal Özkurt, Nuri̇nni̇sa Öztürk, Si̇nan Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Crimean-Congo hemorrhagic fever (CCHF) is a serious illness characterized by fever and hemorrhage. Endothelin-1 (ET-1), angiopoietin-2 (Ang-2), and endothelial cell-specific receptor tyrosine kinase (Tie-2) are believed to be important markers of the pathogenesis, clinical course, and prognosis of the disease. The aim of this study was to determine ET-1, Ang-2, and Tie-2 levels in adults with CCHF and investigate the associations between these markers and pathogenesis and disease course.Materials and methods: Sixty CCHF patients were included in the study. The patients were classified according to disease severity criteria and Ang-2, Tie-2, and ET-1 levels were compared.Results: Mean serum ET-1 …

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Additional Effects Of Erythropoietin Pretreatment, Ischemic Preconditioning, And N-Acetylcysteine Posttreatment In Rat Kidney Reperfusion Injury, Mohammed Elshiekh, Mehri Kadkhodaee, Behjat Seifi, Mina Ranjbaran Jan 2019

Additional Effects Of Erythropoietin Pretreatment, Ischemic Preconditioning, And N-Acetylcysteine Posttreatment In Rat Kidney Reperfusion Injury, Mohammed Elshiekh, Mehri Kadkhodaee, Behjat Seifi, Mina Ranjbaran

Turkish Journal of Medical Sciences

Background/aim: Since the nature of ischemia/reperfusion (IR)-induced tissue damage is multifactorial and complex, in the current study, the effects of multiple treatment strategies via concomitant administration of erythropoietin (EPO) and N-acetylcysteine (NAC) with an ischemic preconditioning (IPC) regimen on renal IR injury were examined.Materials and methods: Thirty male Wistar rats were subjected to bilateral occlusion of the renal pedicles for 50 min followed by reperfusion. EPO (1000 IU/kg) was administered for 3 days, as well as IPC before the IR and NAC (150 mg/kg) administration for 4 days after IR. The animals were randomly allocated into 6 groups (n = …

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Profiling Of 17 Y-Str Loci In Mazandaran And Gilan Provinces Of Iran, Minoo Sayyari, Ali Salehzadeh, Mohamad Amin Tabatabaiefar, Ali Abbasi Jan 2019

Profiling Of 17 Y-Str Loci In Mazandaran And Gilan Provinces Of Iran, Minoo Sayyari, Ali Salehzadeh, Mohamad Amin Tabatabaiefar, Ali Abbasi

Turkish Journal of Medical Sciences

Background/aim: TheY-chromosome mainly consists of heterochromatin regions that have a father-to-son inheritance. Short tandem repeat polymorphic (STRP) markers distributed all over the chromosome provide the opportunity for investigations in forensic medicine and ancestral lineage studies. Due to the existence of wide varieties of geographical and ethnic groups in Iran, studying Y-STRP markers is necessary for further applications. Here we investigated the provinces of Mazandaran and Gilan for the first time. Materials and methods: Samples included 119 and 90 unrelated males from Mazandaran and Gilan, respectively. Using a PCR amplification kit, 17 Y-STRP markers were amplified and genotyping was conducted by …

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Review Of The Effect Of 3d Medical Printing And Virtual Reality On Urology Training With `Medtrain3dmodsim' Erasmus + European Union Project, İlkan Tatar, Emre Huri̇, İlker Selçuk, Young Lee Moon, Alberto Paoluzzi, Andreas Skolarikos Jan 2019

Review Of The Effect Of 3d Medical Printing And Virtual Reality On Urology Training With `Medtrain3dmodsim' Erasmus + European Union Project, İlkan Tatar, Emre Huri̇, İlker Selçuk, Young Lee Moon, Alberto Paoluzzi, Andreas Skolarikos

Turkish Journal of Medical Sciences

Background/aim: It is necessary to incorporate novel training modalities in medical education, especially in surgical fields, because of the limitations of cadaveric training. Traditional medical education has many drawbacks, such as residency working hour restrictions, patient safety conflicts with the learning needs, and the lack of hands-on workshops. The MedTRain3DModsim Project aimed to produce 3-dimensional (3D) medical printed models, simulations, and innovative applications for every level of medical training using novel worldwide technologies. It was aimed herein to improve the interdisciplinary and transnational approaches, and accumulate existing experience for medical education, postgraduate studies, and specialty training. Materials and methods: This …

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The Effect Of Hypoxia On Hearing Function, Nevreste Di̇dem Sonbay Yilmaz, Cem Saka, Burcu Arslan, Nurdan Aygener Yeşi̇lyurt, Di̇lek Saka, Sadik Ardiç, İstemi̇han Akin Jan 2019

The Effect Of Hypoxia On Hearing Function, Nevreste Di̇dem Sonbay Yilmaz, Cem Saka, Burcu Arslan, Nurdan Aygener Yeşi̇lyurt, Di̇lek Saka, Sadik Ardiç, İstemi̇han Akin

Turkish Journal of Medical Sciences

Background/aim: This study was conducted to determine the critical partial oxygen pressure (pO2) value that would impair hearing function by evaluating the effects of hypoxia on hearing function in subjects diagnosed with chronic obstructive pulmonary disease (CPOD).Materials and methods: The study included 25 male and 5 female patients referred to our clinic who were diagnosed with COPD, according to spirometry and PaO2 values, and who did not show pathology upon autoscopic examination. The control group consisted of 14 female and 16 male patients who had no lung disease and were in the same age range as the COPD group. Results: …

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Serum Zinc Levels In Seborrheic Dermatitis: A Case-Control Study, Ezgi̇ Aktaş Karabay, Asli Aksu Çerman Jan 2019

Serum Zinc Levels In Seborrheic Dermatitis: A Case-Control Study, Ezgi̇ Aktaş Karabay, Asli Aksu Çerman

Turkish Journal of Medical Sciences

Background/aim:Malassezia colonization, sebaceous gland activity, hormones, immune system defects, environmental factors, and the interactions between these factors are thought to contribute to the pathogenesis of seborrheic dermatitis (SD). Zinc, an essential element, is involved in many biological processes including the ones that contribute to the development of SD. The aim of this study is to evaluate serum zinc levels in patients with SD.Materials and methods: Forty-three patients with SD and 41 healthy controls were enrolled in the study. Disease activity was assessed by the Seborrheic Dermatitis Area and Severity Index by a single dermatologist. Serum zinc levels of all subjects …

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The Effect Of Isotretinoin On Insulin Resistance And Adipocytokine Levels In Acne Vulgaris Patients, Gonca Soyuduru, Esra Özsoy Adişen, İlkay Özer, Ahmet Burhan Aksakal Jan 2019

The Effect Of Isotretinoin On Insulin Resistance And Adipocytokine Levels In Acne Vulgaris Patients, Gonca Soyuduru, Esra Özsoy Adişen, İlkay Özer, Ahmet Burhan Aksakal

Turkish Journal of Medical Sciences

Recent data draw attention to the effect of body composition, insulin resistance, and adipocytokines to acne vulgaris (AV) development. The aim of this study was to assess the association of AV with insulin resistance and adipocytokine levels and to evaluate the effect of isotretinoin on insulin resistance and adipocytokine levels. Materials and methods: In 29 AV patients and 29 healthy volunteers, body mass index (BMI) and body fat mass (BFM), lipid, adiponectin, leptin, resistin, retinol binding protein-4 (RBP4), and insulin levels were measured and insulin resistance was assessed by HOMA-IR index in serum samples taken twice from patients before and …

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Anticandidal Activities Of Lactic Acid Bacteria Isolated From The Vagina, Sevda Er, Ayşe İstanbullu Tosun, Gi̇zem Arik Berk, Meri̇h Kivanç Jan 2019

Anticandidal Activities Of Lactic Acid Bacteria Isolated From The Vagina, Sevda Er, Ayşe İstanbullu Tosun, Gi̇zem Arik Berk, Meri̇h Kivanç

Turkish Journal of Medical Sciences

Background/aim: Lactic acid bacteria prevent the overgrowth of pathogenic agents and opportunistic pathogens in the vagina. Moreover, lactic acid bacteria contribute to the preservation of vaginal microbiota by producing antimicrobial agents. Previous studies showed that some lactic acid bacteria exhibited antimicrobial activity against Candida species causing yeast vaginosis as well as many bacterial pathogens.Materials and methods: The antifungal activities of various lactic acid bacteria isolated from the vagina of healthy women on some Candida species isolated from the vagina were investigated by agar diffusion technique. Results: Most of the lactic acid bacteria that belong to the species of Lactobacillus crispatus, …

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S1pr2 Deficiency Enhances Neuropathic Pain Induced By Partial Sciatic Nerve Ligation, Qiang Gu, Jin Chao Hou, Xiang Ming Fang Jan 2019

S1pr2 Deficiency Enhances Neuropathic Pain Induced By Partial Sciatic Nerve Ligation, Qiang Gu, Jin Chao Hou, Xiang Ming Fang

Turkish Journal of Medical Sciences

Background/aim: Sphingosine 1-phosphate receptor 2 (S1PR2), a member of the seven-transmembrane receptor family, can be activated by its natural ligand sphingosine 1-phosphate (S1P) to initiate signal transduction and is involved in a wide range of biological effects such as immune cell migration and vascular permeability. Its relationship with neuropathic pain (NP) has not been reported. In this study, the effects of S1PR2 on the development of NP were studied.Materials and methods: We generated a model of NP by partial sciatic nerve ligation (pSNL). The 50% paw withdrawal threshold of the wild-type (WT) group and the S1PR2 deficiency group were measured …

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Cloning And Molecular Characterization Of Thiol-Specific Antioxidant Gene Of Leishmania Tropica Turkey Isolate, Hamza Özavci, Mustafa Kaplan Jan 2019

Cloning And Molecular Characterization Of Thiol-Specific Antioxidant Gene Of Leishmania Tropica Turkey Isolate, Hamza Özavci, Mustafa Kaplan

Turkish Journal of Medical Sciences

Background/aim: Thiol-specific antioxidant (TSA) protein is one of the most promising molecules among candidates for vaccine against cutaneous leishmaniasis. It was found to be significantly protective against different Leishmania species. In this study, cloning and molecular characterization of thiol-specific antioxidant gene of L. tropica Turkey isolate (LtTSA) were aimed. Materials and methods: LtTSA was amplified by PCR using the specific primers of TSA gene and cloned into the pcDNA3.1 vector. The cloning was confirmed by PCR screening, restriction enzyme reactions, and DNA sequence analysis. Finally, three-dimensional structure and antigenic properties of the protein encoded by the LtTSA were determined.Results: Six …

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Determining The Insulin Secretion Potential For Certain Specific G-Protein Coupled Receptors In Min6 Pancreatic Beta Cells, Hasan Gençoğlu, Kazi̇m Şahi̇n, Peter M. Jones Jan 2019

Determining The Insulin Secretion Potential For Certain Specific G-Protein Coupled Receptors In Min6 Pancreatic Beta Cells, Hasan Gençoğlu, Kazi̇m Şahi̇n, Peter M. Jones

Turkish Journal of Medical Sciences

Background/aim: The polypeptide hormone insulin is essential for the maintenance of whole-body fuel homeostasis, and defects in insulin secretion and/or action are associated with the development of type 1 and type 2 diabetes. The aim of this study was to assess the role of some G-protein coupled receptors (GPCRs), GPR54, GPR56, and GPR75, and cannabinoid receptors CB1R and CB2R, in the regulation of pancreatic ß-cell function.Materials and methods: Insulin secretion from mouse insulinoma ß-cell line (MIN6) monolayers was assessed via insulin radioimmu-noassay (RIA). Reverse transcription-polymerase chain reaction (RT-PCR) was used to assess the expression of some specific GPCRs and the …

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Mir-33 And Rip140 Participate In Lps-Induced Acute Lung Injury, Hua Li, Huan Hou, Shuang Liu, Yangyang Feng, Wansi Zhong, Xiaojuan Hu, Nianlong Yan Jan 2019

Mir-33 And Rip140 Participate In Lps-Induced Acute Lung Injury, Hua Li, Huan Hou, Shuang Liu, Yangyang Feng, Wansi Zhong, Xiaojuan Hu, Nianlong Yan

Turkish Journal of Medical Sciences

Background/aim: Pulmonary microvascular endothelial cells (PMVECs) play a pivotal role in the process of acute lung injury (ALI), which can be induced by lipopolysaccharide (LPS). Numerous reports have indicated that both miR-33 and RIP140 are involved in the inflammatory response in macrophages. In this study, we sought to investigate whether miR-33 and RIP140 participate in ALI induced by LPS.Materials and methods: First, we isolated and identified PMVECs from BALB/c mice. Subsequently, both PMVECs and BALB/c mice were treated with PBS, LPS, or pyrrolidine dithiocarbamate (PDTC) plus LPS and divided into three groups: control (PBS), LPS (LPS), and L+P (LPS plus …

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Comparison Of Venous Repair Results Using Either Arterial Or Vein Grafts In A Crush-Avulsion Injury Model, Selami̇ Serhat Şi̇rvan, Işil Akgün Demi̇r, Fati̇h Irmak, Dağhan Dağdelen, Kamuran Zeynep Sevi̇m, Ayşe Ayşi̇m Özağari, Ayşi̇n Karasoy Yeşi̇lada Jan 2019

Comparison Of Venous Repair Results Using Either Arterial Or Vein Grafts In A Crush-Avulsion Injury Model, Selami̇ Serhat Şi̇rvan, Işil Akgün Demi̇r, Fati̇h Irmak, Dağhan Dağdelen, Kamuran Zeynep Sevi̇m, Ayşe Ayşi̇m Özağari, Ayşi̇n Karasoy Yeşi̇lada

Turkish Journal of Medical Sciences

Background/aim: Venous insufficiency after replantation or revascularization is one of the most common causes of limb loss in either the short or the long term. The aim of this study was to evaluate the results of a new technique to overcome venous insufficiency.Materials and Methods: A crush-avulsion type of injury was formed in the femoral veins of rats of 3 separate groups. In the control group, primary repair was applied to the damaged veins and the remaining 2 groups were repaired with either an arterial graft or a vein graft. The success rates of anastomosis were then compared.Results: In the …

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Seroprevalence Of Hantavirus And Borreliaburgdorferi In Düzce (Turkey) Forest Villages And The Relationship With Sociodemographic Features, Ni̇da Akar, Emel Çalişkan, Ci̇hadi̇ye Eli̇f Öztürk, Handan Ankarali, Özge Kilinçel, Şükrü Öksüz, İdri̇s Şahi̇n Jan 2019

Seroprevalence Of Hantavirus And Borreliaburgdorferi In Düzce (Turkey) Forest Villages And The Relationship With Sociodemographic Features, Ni̇da Akar, Emel Çalişkan, Ci̇hadi̇ye Eli̇f Öztürk, Handan Ankarali, Özge Kilinçel, Şükrü Öksüz, İdri̇s Şahi̇n

Turkish Journal of Medical Sciences

Background/aim: Hantavirus and Borrelia burgdorferi are two zoonotic agents that pose a great risk especially for people living in forest areas. This study aimed to investigate the seroprevalence of hantavirus and B. burgdorferi in forest villages of Düzce and its relationship with sociodemographic features.Materials and methods: The presence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against hantavirus and B. burgdorferi in serum samples was investigated via enzyme-linked immunosorbent assay (ELISA). Hantavirus IgG and B. burgdorferiIgM and IgG positivity was then validated by western blot (WB) method. Results: During the analyses,193 serum samples were tested. Eleven (6%) cases of …

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Investigation Of Treatment Efficacy Of 10% Povidone-Iodine Sclerotherapy On Ovarian Cyst Diameter: An Experimental Study, Remzi̇ Atilgan, Şehmus Pala, Tuncay Kuloğlu Jan 2019

Investigation Of Treatment Efficacy Of 10% Povidone-Iodine Sclerotherapy On Ovarian Cyst Diameter: An Experimental Study, Remzi̇ Atilgan, Şehmus Pala, Tuncay Kuloğlu

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was toinvestigate the effects of 10% povidone-iodine (PI) sclerotherapyon ovarian cyst diameter through an experimental study.Materials and methods: To be able to create ovarian cysts, right unilateral salpingectomy was performed on 20 Wistar albino rats. One month after the operation, the abdomens of all rats were reopened. Sixteen rats with macroscopic ovarian cysts were divided randomly into 2 groups consisting of 8 rats. Group 1 (G1): the cyst content was only aspirated. Group 2 (G2): the ovarian cyst was aspirated and then the cystic cavity was irrigated with PI. Abdomens of all rats were …

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Serum S100a12 And S100b Proteins Are Independent Predictors Of The Presence And Severity Of Obstructive Sleep Apnea, Gözde Demi̇rci̇ Sağlam, Adi̇l Zamani̇, Şebnem Yosunkaya, İbrahi̇m Kilinç Jan 2019

Serum S100a12 And S100b Proteins Are Independent Predictors Of The Presence And Severity Of Obstructive Sleep Apnea, Gözde Demi̇rci̇ Sağlam, Adi̇l Zamani̇, Şebnem Yosunkaya, İbrahi̇m Kilinç

Turkish Journal of Medical Sciences

Background/aim: Obstructive sleep apnea (OSA) is associated with serious cardiometabolic risks. Early diagnosis and treatment compliance are important. For this purpose, research is being carried out on biomarkers associated with the pathogenesis of the disease. We aimed to investigate whether serum S100A12 and S100B proteins could be used as biochemical markers in OSA patients to determine disease presence and severity. Materials and methods: A total of 60 (16 women, 44 men) patients with OSA and 50 (20 women, 30 men) controls were enrolled in this cross-sectional study. Each subject included in the study underwent full-night polysomnography (PSG). The presence and …

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