Digital Commons Network^™

การเรียนรู้เชิงรุกผ่านเว็บไซต์เพื่อสร้างแผนธุรกิจนวัตกรรม: ผู้เรียนระดับปริญญาตรี, ศราวณี พึ่งผู้นำ

Chulalongkorn University Theses and Dissertations (Chula ETD)

งานวิจัยนี้มีวัตถุประสงค์เพื่อพัฒนาเว็บไซต์สำหรับเขียนแผนธุรกิจที่สนับสนุนนวัตกรรมสำหรับนักศึกษาระดับปริญญาตรี การเขียนแผนธุรกิจถือได้ว่าเป็นหนึ่งในกิจกรรมที่สำคัญของการเป็นผู้ประกอบการและมีความเกี่ยวข้องกับกิจกรรมหลักของการศึกษาระดับอุดมศึกษามากขึ้นเรื่อย ๆ ในการศึกษานี้ได้เสนอ Collaborative Website ชื่อ BRAINY Business Model การศึกษาข้อมูลเชิงปริมาณจากแบบสอบถามของนักศึกษาระดับปริญญาตรี 432 คน (นักศึกษาชั้นปีที่ 3 และปีที่ 4 จาก 11 มหาวิทยาลัยในประเทศไทย) ในแง่ของเนื้อหาต่างๆ และการเข้าใช้ระบบ ผู้ใช้ต้องการจะสามารถเข้าใช้งานเว็บไซต์ได้โดยไม่ต้องจ่ายเงินในระดับสูงสุด (Mean = 4.375, S.D. = 1.003) และข้อมูลเชิงคุณภาพจากการสัมภาษณ์กลุ่มเป้าหมาย (นักศึกษาระดับปริญญาตรี 11 คน ซึ่งมีประสบการณ์ในการแข่งขันแผนธุรกิจ) พบว่า มีความสนใจใช้เว็บไซต์นี้ ผลการวิจัยยังชี้ให้เห็นถึงความต้องการในการเข้าถึงเว็บไซต์โดยมีระบบความปลอดภัย และต้องการดูวิดีโอสั้นๆ จุดเด่นของระบบนี้คือการเพิ่มเครื่องมือที่ช่วยให้นักเรียนมีความคิดสร้างสรรค์ในการค้นหานวัตกรรมซึ่งก็คือ TRIZ ที่ให้แนวทางเชิงตรรกะในการพัฒนาความคิดสร้างสรรค์สำหรับนวัตกรรมและการแก้ปัญหา ในส่วนของการทดลองใช้เว็บไซต์นี้ ผู้วิจัยใช้รูปแบบกึ่งทดลอง แบ่งผู้เรียนเป็น 2 กลุ่ม คือ กลุ่มทดลองที่ได้ใช้เว็บไซต์นี้ และกลุ่มควบคุมที่ใช้เว็บไซต์อื่น ผลการทดสอบสมมติฐาน พบว่า กลุ่มทดลองมีคะแนนในด้านต่างๆ สูงกว่ากลุ่มควบคุมอย่างมีนัยสำคัญทางสถิติ ได้แก่ ด้านระดับความใหม่ของผลิตภัณฑ์ ความคิดสร้างสรรค์ ความเกี่ยวข้องสอดคล้องกับ Theme งาน คือ เรื่องเกี่ยวกับผลิตภัณฑ์ใหม่ที่จะตอบสนองแนวโน้มที่เกิดในสังคมได้ และความถูกต้องทางวิชาการ ส่วนด้านเชิงพาณิชย์ ไม่มีนัยสำคัญทางสถิติ และจากการศึกษาความเป็นไปได้ทางการเงินของการลงทุนผลิตระบบนวัตกรรมนี้มีค่า NPV เท่ากับ 1,990,434.49 บาท IRR เท่ากับ 47.86% และระยะเวลาคืนทุน 2 ปี 4 เดือน

Salivary Proteomic Analysis For Detection And Monitoring Treatment Response In Canine Oral Tumors, Sekkarin Ploypetch

Chulalongkorn University Theses and Dissertations (Chula ETD)

Tumors of the oral cavity account for 8% of all canine neoplasia. Malignant oral mass such as melanoma, oral squamous cell carcinoma (OSCC) and fibrosarcoma covers approximately 59% of canine oral neoplasia. Among these, canine oral melanoma (COM) is the most common oral tumors in dogs, with approximately 30–40% of all oral tumors. With high recurrence and/or distant metastasis rate, biomarkers are required for early detection, diagnosis, prognosis, and monitoring treatment response. Since saliva directly contacts tumors and saliva collection is non-invasive, easily accessible and cost effective, salivary biomarkers are suitable to support the evaluation of oral diseases. This study …

Computational Design And Production Of Levansucrase With Increased Thermostability, Methus Klaewkla

Chulalongkorn University Theses and Dissertations (Chula ETD)

Levansucrase is a carbohydrate-modifying enzyme that catalyzes hydrolysis of sucrose and transfructosylation of a fructosyl unit of sucrose to produce levan and levan-type fructooligosaccharides (LFOs). Due to their various beneficial properties such as low viscosity and non-toxicity. Levan and LFOs have potential applications in many industries such as prebiotics in food industries and anti-tumor agents in pharmaceutical industries. Previous study found that the Y246S mutant of Bacillus licheniformis RN-01 levansucrase (Oligosaccharide Producing Levansucrase, OPL) could effectively produce LFOs, but its thermostability is limited at high temperature. In this study, molecular dynamics (MD) and computational protein design were used to design …

Tyrosinase Inhibitors From Some Plants, Ponglada Sadangrit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Tyrosinase is the key enzyme in melanogenesis leading to skin darkening. Many skin whitening products contain tyrosinase inhibitors or extracts that inhibit tyrosinase activity. Moreover, natural extracts are one of the most popular alternatives. They are safe and have less side effects. To determine the effects of plant compounds on melanogenesis, tyrosinase activity was evaluated in in vitro and cellular screening. Melanin level was measured in B16F10 melanoma cells. In addition, the gene expression level of melanogenesis-related genes was explored by quantitative reverse transcriptase polymerase chain reaction. Fifteen plant compounds were tested by in vitro mushroom tyrosinase inhibition assay to …

Biocompatible Materials Loaded With Plant Extract For Ph Sensing, Kasitnun Chayavanich

Chulalongkorn University Theses and Dissertations (Chula ETD)

The pH-sensitive films and resin were developed based on natural pH-sensitive coloring agents and biocompatible polymers. Anthocyanins and a curcumin derivative were selected as the natural pH-sensitive coloring agents. At first, anthocyanins were extracted from red radish and their contents were determined by using the pH-differential method. Difluoro boron curcumin was synthesized to improve its photophysical and stability properties. Next, both coloring agents were characterized by UV-Vis, FT-IR, and NMR techniques as well as their color response in solution was studied in different pHs with UV-Vis profiles. The results showed that the red radish anthocyanin solution could change the colors …

Preparation Of Antimicrobial And Water Repellent Cotton Fabric Coated With Organosilane-Modified Cellulose Nanofiber From Sugarcane Bagasse Waste, Intatch Hongrattanavichit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nosocomial infection or hospital acquired infection is the major factor for micro- and macro- economic issues since this contagion provides physical and psychological suffering of infected patients and their own families. Moreover, the government has to subsidize for new case reduction and relief in which this infection trends to increase every year. Thus, this research aimed to solve this main issue by reducing the pathway of cross-contamination on the textile products. Coating textiles with antimicrobial and water-repellent material was selected for this work. The coating material was produced using cellulose nanofibers from sugarcane bagasse waste which sugarcane is the important …

Campaign Structure Distillation For Methyl Palmitate Separation From Palm Oil Biodiesel Using Vacuum Batch Distillation, Supakorn Songpanit

Chulalongkorn University Theses and Dissertations (Chula ETD)

Nowadays, the competition of palm oil biodiesel production in Thailand will increase essentially in the sector for the next few years. Therefore, this study aims to find a new approach for converting palm oil biodiesel or fatty acid methyl ester mixture, into a specialty chemical to increase the value of palm oil biodiesel. Campaign structure distillation was considered to design a separation process using vacuum batch distillation, and turn only one batch process into the sequence of methyl ester cut as a continuous process. The objective is to study the effect of operating parameters on campaign structure distillation for methyl …

การลดก๊าซเรือนกระจกจากการอนุรักษ์พลังงานและการจัดการขยะมูลฝอยของสถานศึกษา, นิภาพร เดโชเกียรติถวัลย์

Chulalongkorn University Theses and Dissertations (Chula ETD)

สถานศึกษาเป็นหน่วยงานขนาดใหญ่ที่ประกอบไปด้วยกิจกรรมที่มีความหลากหลาย จึงถือเป็นองค์กรที่สำคัญแห่งหนึ่งซึ่งมีการใช้พลังงานสูงทั้งในรูปพลังงานไฟฟ้าและเชื้อเพลิง นอกจากนี้ยังก่อให้เกิดขยะปริมาณมาก ซึ่งหมายถึงเป็นแหล่งของการปล่อยก๊าซเรือนกระจกสูงด้วย งานวิจัยนี้ได้ทำการประเมินคาร์บอนฟุตพริ้นท์องค์กรของสถานศึกษาพร้อมทั้งศึกษาแนวทางการลดการปล่อยก๊าซเรือนกระจกจากการอนุรักษ์พลังงงานและการจัดการขยะมูลฝอย ผลการศึกษาพบว่า ในปีพ.ศ. 2561 มหาวิทยาลัย ก มหาวิทยาลัย ข และวิทยาลัย ค มีปริมาณการปล่อยก๊าซเรือนกระจกทั้งหมดเท่ากับ 5,912.32 6,487.32 และ 1,458.05 ตันคาร์บอนไดออกไซด์เทียบเท่าต่อปี ตามลำดับ โดยการใช้พลังงานไฟฟ้าในขอบเขตที่ 2 และการกำจัดขยะในขอบเขตที่ 3 เป็นกิจกรรมที่ส่งผลต่อการปล่อยก๊าซเรือนกระจกมากที่สุดเป็นอันดับ 1 และ 2 ตามลำดับ มาตรการอนุรักษ์พลังงานซึ่งมีศักยภาพในการลดก๊าซเรือนกระจกและมีความคุ้มค่าทางเศรษฐศาสตร์ ได้แก่ มาตรการการเปลี่ยนไปใช้เครื่องปรับอากาศและเครื่องทำน้ำเย็นประสิทธิภาพสูง การติดตั้งอุปกรณ์ควบคุมความเร็วรอบเครื่องสูบน้ำเย็น การเปลี่ยนไปใช้หลอดไฟแบบ LED และการติดตั้ง Solar rooftop บนอาคาร นอกจากนี้การจัดการขยะมูลฝอยซึ่งมีประสิทธิภาพในการลดก๊าซเรือนกระจก สามารถทำได้โดยการจัดการขยะแบบผสมผสาน ได้แก่ การฝังกลบร่วมกับการคัดแยกขยะเพื่อการรีไซเคิล การนำเศษอาหารไปเป็นอาหารสัตว์ และการนำใบไม้มาทำสารปรับปรุงดิน

Evidence-Based Music Therapy Treatment To Elevate Mood During Acute Stroke Care, Jessica L. Rushing

Theses and Dissertations--Rehabilitation Sciences

Stroke is the fifth leading cause of death in the U.S. with approximately 795,000 Americans experiencing a stroke each year. In addition to common difficulties with communication and physical impairments following stroke, psychosocial impacts warrant assessment and treatment. Experiencing a stroke can lead to depression, mood disorders, and difficulties with emotion regulation. It is well documented that post-stroke depression (PSD) affects a third of stroke survivors. Higher levels of depression and depressive symptoms are associated with a less efficient use of rehabilitation services, poor functional outcomes, greater odds of hospital readmission, negative impacts on social participation, and increased mortality. The …

Imi – Myopia Control Reports Overview And Introduction, James S. Wolffsohn, Daniel Ian Flitcroft, Kate L. Gifford, Monica Jong, Lyndon Jones, Caroline C. W. Klaver, Nicola S. Logan, Kovin Naidoo, Serge Resnikoff, Padmaja Sankaridurg, Earl L. Smith Iii, David Troilo, Christine F. Wildsoet

Articles

With the growing prevalence of myopia, already at epidemic levels in some countries, there is an urgent need for new management approaches. However, with the increasing number of research publications on the topic of myopia control, there is also a clear necessity for agreement and guidance on key issues, including on how myopia should be defined and how interventions, validated by well-conducted clinical trials, should be appropriately and ethically applied. The International Myopia Institute (IMI) reports the critical review and synthesis of the research evidence to date, from animal models, genetics, clinical studies, and randomized controlled trials, by more than …

"Don't Have A Cow" . . . Or The Restatement (Second), David G. Epstein, Roxanne M. Eastes

Law Faculty Publications

“Don’t have a cow” is not only Bart Simpson’s mantra but also the admonition of the Michigan Supreme Court in Lenawee County Board of Health v. Messerly. For almost a hundred years, law students and lawyers had a cow to instruct them on the law of mistake: Rose II of Aberlone – the cow in Sherwood v. Walker.

Most American lawyers and judges have read Sherwood v. Walker in their contracts casebook and/or have heard their contracts professor talk about the Michigan Supreme Court decision in Sherwood v. Walker and Rose II of Aberlone. Lawyers of a certain age remember …

Differential Associations Of Distinct Forms Of Childhood Adversity With Neurobehavioral Measures Of Reward Processing: A Developmental Pathway To Depression, Meg J. Dennison, Maya L. Rosen, Kelly A. Sambrook, Jessica L. Jenness, Margaret A. Sheridan, Katie A. Mclaughlin

Neuroscience: Faculty Publications

Childhood adversity is associated with altered reward processing, but little is known about whether this varies across distinct types of adversity. In a sample of 94 children (6–19 years), we investigated whether experiences of material deprivation, emotional deprivation, and trauma have differential associations with reward-related behavior and white matter microstructure in tracts involved in reward processing. Material deprivation (food insecurity), but not emotional deprivation or trauma, was associated with poor reward performance. Adversity-related influences on the integrity of white matter microstructure in frontostriatal tracts varied across childhood adversity types, and reductions in frontostriatal white matter integrity mediated the association of …

Frank Beach Award Winner: Neuroendocrinology Of Group Living, Annaliese K. Beery

Neuroscience: Faculty Publications

Why do members of some species live in groups while others are solitary? Group living (sociality) has often been studied from an evolutionary perspective, but less is known about the neurobiology of affiliation outside the realms of mating and parenting. Colonial species offer a valuable opportunity to study nonsexual affiliative behavior between adult peers. Meadow voles (Microtus pennsylvanicus) display environmentally induced variation in social behavior, maintaining exclusive territories in summer months, but living in social groups in winter. Research on peer relationships in female meadow voles demonstrates that these selective preferences are mediated differently than mate relationships in …

A Review Of The Putative Causal Mechanisms Associated With Lower Macular Pigment In Diabetes Mellitus, Grainne Scanlon, James Loughman, Donal Farrell, Daniel Mccartney

Articles

Macular pigment (MP) confers potent antioxidant and anti-inflammatory effects at the macula, and may therefore protect retinal tissue from the oxidative stress and inflammation associated with ocular disease and ageing. There is a body of evidence implicating oxidative damage and inflammation as underlying pathological processes in diabetic retinopathy. MP has therefore become a focus of research in diabetes, with recent evidence suggesting that individuals with diabetes, particularly type 2 diabetes, have lower MP relative to healthy controls. The present review explores the currently available evidence to illuminate the metabolic perturbations that may possibly be involved in MP’s depletion. Metabolic co-morbidities …

The Myth Of Settlement In Mdl Proceedings, Douglas G. Smith

Kentucky Law Journal

No abstract provided.

Don't Forget To Subscribe: Regulation Of Online Advertising Evaluated Through Youtube's Monetization Problem, Nicole E. Pottinger

Kentucky Law Journal

No abstract provided.

Antibiotics And Antimicrobial Resistance: An Evaluation Of The Knowledge, Attitude And Perception Among Dental Students And Academic Deans And Department Chairs Within U.S. Dental Schools, Magdalena S. Holz

Theses and Dissertations

Purpose: This study aimed to survey current 3^rd and 4^th year dental students, academic deans, and department chairs within U.S. dental schools to analyze the level of understanding; education; guidelines; and overall awareness regarding antibiotic use within dentistry and antimicrobial resistance.

Methods: A 25-question survey intended for 3^rd and 4^th year dental students and a 20-question survey intended for academic deans and various department chairs of U.S dental schools were each developed utilizing REDCap. The survey invitations were sent via e-mail to the current academic dean of each U.S. dental school for distribution.

Results: There were …

Designing Biomimetic Implant Surfaces To Promote Osseointegration Under Osteoporotic Conditions By Revitalizing Mechanisms Coupling Bone Resorption To Formation, Ethan M. Lotz

Theses and Dissertations

In cases of compromised bone remodeling like osteoporosis, insufficient osseointegration occurs and results in implant failure. Implant retention relies on proper secondary fixation, which is developed during bone remodeling. This process is disrupted in metastatic bone diseases like osteoporosis. Osteoporosis is characterized low bone mass and bone strength resulting from either accelerated osteoclast-mediated bone resorption or impaired osteoblast-mediated bone formation. These two processes are not independent phenomena. In fact, osteoporosis can be viewed as a breakdown of the cellular communication connecting bone resorption to bone formation. Because bone remodeling occurs at temporally generated specific anatomical sites and at different times, …

Geology Of Southeastern Nebraska, Robert Matthew Joeckel, Dana Divine, Leslie M. Howard, Kathleen Cameron, Michele M. Waszgis

Conservation and Survey Division: Faculty and Staff Publications

No abstract provided.

Dnmt3a In The Hippocampal Ca1 Is Crucial In The Acquisition Of Morphine Self‐Administration In Rats, Jian-Jun Zhang, Feng-Ze Jiang, Wei Zheng, Ying Duan, Su-Bo Jin, Fang Shen, Jing Liang, Ming Li, Nan Sui

Department of Psychology: Faculty Publications

Drug‐reinforced excessive operant responding is one fundamental feature of long-lasting addiction‐like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug‐specific (not natural rewards) operant behavior are not entirely clear. In this study, we demonstrate a key role for one of the de novo DNA methyltransferase, DNMT3a, in the acquisition of morphine self‐administration (SA) in rats. The expression of DNMT3a in the hippocampal CA1 region but not in the nucleus accumbens shell was significantly up‐regulated after 1‐ and 7‐day morphine SA (0.3 mg/kg/infusion) but not after the yoked morphine injection. On the other hand, saccharin …

Crime On Campus 2019, Tennessee. Bureau Of Investigation

Crime on Campus

The “Crime on campus” reporting program is operated pursuant to the requirements of the “College and University Security Information Act”, (T.C.A. § 49-7-2201 et. seq.) enacted by the General Assembly of the State of Tennessee, effective July 1, 1989. The Act requires each institution of higher education to report to the Tennessee Bureau of Investigation data relating to crimes occurring on the campus and in student housing.

The Social Interaction Model Of Objectification: A Process Model Of Goal-Based Objectifying Exchanges Between Men And Women, Sarah Gervais, Gemma Sáez, Abigail R. Riemer, Olivier Klein

Department of Psychology: Faculty Publications

People perceive and treat women as sex objects in social exchanges. The interaction processes through which women are objectified, however, have rarely been considered. To address this gap in the literature, we propose the Social Interaction Model of Objectification (SIMO). Rooted in social exchange and objectification theories, the SIMO predicts objectifying behaviors stemming from sexual goals between men and women. We propose that the behavioral dynamics of objectification can be understood through a series of goal-based exchange processes that are shaped by patriarchy. Articulating the SIMO and its predictions for Behavior in social interactions, we describe the scant social psychological …

Management Strategy Evaluation: Transdisciplinary And Transparent Natural Resource Management, Eileen Hofmann, Lisa Maddison, Ingrid Van Putten

CCPO Publications

Management Strategy Evaluation (MSE) is a modelling tool used to evaluate sufficiently realistic simulations of potential policy choices in complex systems. As a contribution to the Integrated Marine Biosphere Research (IMBeR) project IMBIZO V, which occurred in October 2017, a workshop was convened with the goal of developing a coherent understanding of best-practice approaches for MSEs. MSEs are becoming standard approaches to characterizing risk across fisheries management organizations globally. MSEs are important tools that aid in delineating objectives, costs, and constraints that define risk and provide a possible mechanism to meet assessment challenges. The MSE workshop considered case studies drawn …

Approach To Constitutional Principles And Environmental Discretion In Canada, Lynda Collins, Lorne Sossin

Articles & Book Chapters

One of the most important and least scrutinized areas of environmental policy is the exercise of administrative discretion. Those committed to environmental action tend to focus on law reform, international treaties, and political commitments - for example, election proposals for carbon taxes and pipelines, or environmental protections in global protocols and trade agreements. Many proponents of stronger environmental protection have focused their attention on the goal of a constitutional amendment recognizing an explicit right to a healthy environment, while others seek recognition of environmental protection within existing Charter rights. As the rights conversation evolves, advocates must continue to grapple with …

If There Can Only Be ‘One Law’, It Must Be Treaty Law. Learning From Kanawayandan D’Aaki, Dayna Nadine Scott, Andrée Boisselle

Articles & Book Chapters

The paper stems from a research collaboration with the Anishini community of Kitchenuhmaykoosib Inninuwug (KI), known as the people of Big Trout Lake in the far north of Ontario. In the face of renewed threats of encroachment by extractive industries onto their homelands, our research team visited the community on the invitation of leadership in 2017. The community was engaged in strategic planning and reflection on the work that they have done in recent years to articulate and record their own laws for the territory, and to gain recognition for those laws from settler governments. Between 2008 and 2018, …

The Employment Standards Enforcement Gap And The Overtime Pay Exemption In Ontario, Mark P. Thomas, Leah F. Vosko, Eric Tucker, Mercedes Steedman, Andrea M. Noack, John Grundy, Mary Gellatly, Lisa Leinveer

Articles & Book Chapters

Employment Standards (es) legislation sets minimum terms and conditions of employment in areas such as wages, working time, vacations and leaves, and termination and severance. es legislation is designed to provide minimum workplace protections, particularly for those with little bargaining power in the labour market. In practice, however, es legislation includes ways in which legislated standards may be avoided, including through exemptions that exclude specified employee groups, fully or partially, from legislative coverage. With a focus on the Ontario Employment Standards Act, this article develops a case study of exemptions to the overtime pay provision of the act and regulations …

Value Creation: A Constant Principle In A Changing World Of International Taxation, Jinyan Li, Nathan Jin Bao, Huaning Li

Articles & Book Chapters

The authors consider the new nomenclature of value creation in terms of its meaning, theoretical basis, and importance in the context of the international taxation of business profits. The authors’ central claim is that the principle of value creation is a profound elaboration of the doctrine of economic allegiance, which is the theoretical basis for the current international tax system; and that international tax norms, such as the arm’s-length principle, are meant to give effect to the doctrine of economic allegiance (and now to the principle of value creation). As demonstrated by the Organisation for Economic Co-operation and Development/Group of …

Masked By Trust: Bias In Library Discovery, Matthew Reidsma

Books and Contributions to Books

The rise of Google and its integration into nearly every aspect of our lives has pushed libraries to adopt similar "Google-like" search tools, called discovery systems. Because these tools are provided by libraries and search scholarly materials rather than the open web, we often assume they are more "accurate" or "reliable" than their general-purpose peers like Google or Bing. But discovery systems are still software written by people with prejudices and biases, library software vendors are subject to strong commercial pressures that are often hidden behind diffuse collection-development contracts and layers of administration, and they struggle to integrate content from …

Metaphorical Imagery In Colossians: The Narrative Of Christian Living, Paul Muther

Master of Sacred Theology Thesis

Muther, Paul D. “Metaphorical Imagery in Colossians: The Narratives of Christian Living.” STM thesis, Concordia Seminary, 2019. 114 pp.

Although many recent theologians employ conceptual metaphor theory to the Bible’s imagery surrounding the Gospel, few apply the same theory to the metaphors of Christian living. Although many theologians develop models to demonstrate the overall picture of Christian living, few tease out the implications of individual metaphors throughout a given work.

By applying conceptual metaphor theory and Justin Rossow’s narrative analysis tool of the actantial model to the text of Paul’s letter to the Colossians, this STM thesis examines three metaphors …

Design And Evaluation Of Heterobivalent Par1–Par2 Ligands As Antagonists Of Calcium Mobilization, Mark W. Majewski, Disha M. Gandhi, Ricardo Rosas Jr., Revathi Kodall, Leggy A. Arnold, Chris Dockendorff

Chemistry Faculty Research and Publications

A novel class of bivalent ligands targeting putative protease-activated receptor (PAR) heteromers has been prepared based upon reported antagonists for the subtypes PAR1 and PAR2. Modified versions of the PAR1 antagonist RWJ-58259 containing alkyne adapters were connected via cycloaddition reactions to azide-capped polyethylene glycol (PEG) spacers attached to imidazopyridazine-based PAR2 antagonists. Initial studies of the PAR1–PAR2 antagonists indicated that they inhibited G alpha q-mediated calcium mobilization in endothelial and cancer cells driven by both PAR1 and PAR2 agonists. Compounds of this novel class hold promise for the prevention of restenosis, cancer cell metastasis, and other proliferative disorders.