Digital Commons Network^™

A Fragment Of Apolipoprotein E4 Leads To The Downregulation Of A Cxorf56 Homologue, A Novel Er-Associated Protein, And Activation Of Bv2 Microglial Cells, Tanner B. Pollock, Jacob M. Mack, Noail F. Isho, Raquel J. Brown, Alexandra E. Oxford, Brad E. Morrison, Eric J. Hayden, Troy T. Rohn

Biology Faculty Publications and Presentations

Despite the fact that harboring the apolipoprotein E4 (APOE4) allele represents the single greatest risk factor for late-onset Alzheimer’s disease (AD), the exact mechanism by which apoE4 contributes to disease progression remains unknown. Recently, we demonstrated that a 151 amino-terminal fragment of apoE4 (nApoE4_1-151) localizes within the nucleus of microglia in the human AD brain, suggesting a potential role in gene expression. In the present study, we investigated this possibility utilizing BV2 microglia cells treated exogenously with nApoE4_1-151. The results indicated that nApoE4_1-151 leads to morphological activation of microglia cells through, at least in part, …

Recovery Of Stem Cell Proliferation By Low Intensity Vibration Under Simulated Microgravity Requires Linc Complex, H. Touchstone, R. Bryd, S. Loisate, M. Thompson, X. Pu, R. Beard, J. T. Oxford, G. Uzer

Mechanical and Biomedical Engineering Faculty Publications and Presentations

Mesenchymal stem cells (MSC) rely on their ability to integrate physical and spatial signals at load bearing sites to replace and renew musculoskeletal tissues. Designed to mimic unloading experienced during spaceflight, preclinical unloading and simulated microgravity models show that alteration of gravitational loading limits proliferative activity of stem cells. Emerging evidence indicates that this loss of proliferation may be linked to loss of cellular cytoskeleton and contractility. Low intensity vibration (LIV) is an exercise mimetic that promotes proliferation and differentiation of MSCs by enhancing cell structure. Here, we asked whether application of LIV could restore the reduced proliferative capacity seen …

Nebraska's Advantage: Productive Agriculture And Bountiful Natural Resources, Laura E. Young, Mary Garbacz, Michael J. Boehm, Bethany Karlberg, John Carroll, Kathryn Bagniewski, Daran Rudnick, Halle Ramsey, Marc Libault, Cadrien Livingston, Jamilynn Poletto, Leanne Gamet, Troy Gilmore, Natalie Jones, Lisa Pennisi, Elizabeth Vanwormer, Abby Steffen, Andrea Basche, Rylie Kalb, Rick Koelsch, Bethany Karlberg, Martha Shulski, Michael Hayes, Peter Mccornick, Amit Jhala, Walter Schacht, Stanosh Pitla, Michael Ferguson, John Gamon, Joe Luck, Tami M. Brown-Brandl, Bertrand Clarke, Taro Mieno

Strategic Discussions for Nebraska

Nebraska's Advantage: Productive Agriculture and Bountiful Natural Resources

You can’t talk about healthy production systems and natural resource systems without also thinking about the resilience. We need to harmonize production agriculture in a way that ensures the resilience of our natural ecosystems and rural communities—all while addressing bundles of grand challenges.

Nebline, January 2019

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

2018 Extension highlights

Benefit to people

Teaching, growing and making a difference

36,520 youth engaged in 4-H programs

Extension’s volunteers worth nearly $700,000

New Year, new you: Nutrition tips to a healthier you

RECIPE OF THE MONTH

Pesticide applicator 2019 training dates

Ag Estate and Succession Planning workshop, Jan. 23 & March 5

Successful Farmer Series

Upcoming green industry conferences

Extension’s 2019 Master Gardener trainings, two sites available

Garden Guide Things to Do This Month

Sticky situation: Using glue boards to monitor pests

HEART OF 4-H Volunteer Award: Susan Bulling

IT’S TIME TO RE-ENROLL IN 4-H!

Meet 2018–2019 4-H Council …

Ncuwm Talk Abstracts 2019

Nebraska Conference for Undergraduate Women in Mathematics

No abstract provided.

Past Invasive Species Advisory Committee (Isac) Members, National Invasive Species Committee

National Invasive Species Council

United States Department of the Interior

National Invasive Species Council

Invasive Species Advisory Committee (ISAC)

Past ISAC Members:

Class 9 (2016-2019)

Class 8 (2011-2016/2017)

Class 7 (2011-2012/2014)

Class 6 (2009-2011/2012)

Class 5 (2008/2009-2010)

Class 4 (2006-2008)

Class 3 (2004-2006)

Class 2 (2002-2004)

Class 1 (1999-2001)

Age-0 Walleye Sander Vitreus Display Length-Dependent Diet Shift To Piscivory, Christopher S. Uphoff, Casey W. Schoenebeck, Keith D. Koupal, Kevin L. Pope, W. Wyatt Hoback

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

The ontogenetic diet shift to piscivory can be energetically beneficial for fish growth and allows larger, more energetically profitable prey to be consumed. A shift to piscivory may be easier for longer individuals within a cohort due to larger gape size, and an early shift is likely advantageous, potentially leading to increased growth rates and survival. Such length-dependent ontogenetic diet shifts may explain the intracohort variability in length that is common for age-0 walleye (Sander vitreus). The objectives of this study were to describe seasonal intracohort variability in length, identify the timing of the shift to piscivory and …

Ecosystem Size Predicts Social-Ecological Dynamics, Mark A. Kaemingk, Christopher J. Chizinski, Craig R. Allen, Kevin L. Pope

Nebraska Cooperative Fish and Wildlife Research Unit: Staff Publications

Recreational fisheries are complex adaptive systems that are inherently difficult to manage because of heterogeneous user groups (consumptive vs. nonconsumptive) that use patchily distributed resources on the landscape (lakes, rivers, coastlines). There is a need to identify which system components can effectively predict and be used to manage nonlinear and cross-scale dynamics within these systems. We examine how ecosystem size or water body size can be used to explain complicated and elusive angler-resource dynamics in recreational fisheries. Water body size determined angler behavior among 48 Nebraska, U.S.A. water bodies during an 11- year study. Angler behavior was often unique and …

Dissemination, Access, Preservation: A Case Study Of Publications From The Organic Agriculture Research And Extension Initiative, Leslie M. Delserone

University of Nebraska-Lincoln Libraries: Faculty Publications

The Organic Agriculture Research and Extension Initiative, administered by USDA-NIFA, is the major federal funder of organic agricultural research. Analysis of 733 publications produced during the initiative’s first five years explored the dissemination of this research, and accessibility to and preservation of the publications. Publications associated with conferences (e.g., abstracts) were most numerous (36%). Many publications (69%) were openly accessible online in 2017 but fewer than 10% of these appeared in a stable digital repository. In four of the eight publication categories, access disappeared over time. No program exists to systematically collect and preserve these outputs of organic agricultural research. …

Representation Of Unaccompanied Migrant Children From Central America In The United States: Media Vs. Migrant Perspectives, Theresa Catalano, Jessica Mitchell-Mccollough

Department of Teaching, Learning, and Teacher Education: Faculty Publications

This chapter examines the representation of unaccompanied minors fleeing Central America (namely Honduras, Guatemala and El Salvador) in U.S. online national news sources over a one-year period and compares this to the way these children talk about their own perceptions of migration and their motivation for moving. Data collection consisted of online news reports on unaccompanied minors from Central America in the United States as well as interviews with children collected from the United Nations Refugee Agency (UNHCR) and other humanitarian organizations. Multimodal critical discourse analysis reveals a qualitative difference in discourse (e.g., use of metaphor, metonymy, deixis and visual …

2019 Annual Report, Ben Bohall, John Erixson

Nebraska Forest Service: Publications

No abstract provided.

2019 Annual Report Nebraska Game And Parks

Nebraska Game and Parks Commission: Publications

No abstract provided.

How Do Teachers Use Comics To Promote Engagement, Equity, And Diversity In Science Classrooms?, Camilla Matuk, Talia Hurwich, Amy Spiegel, Judy Diamond

World of Viruses

Equitable learning opportunities are critical to the goals of science education. However, major curriculum standards are vague on how to achieve equity goals, and educators must often develop their own resources and strategies to achieve equity goals. This study examines how educators used a comic book series designed to interest youth in virology as a way to make science more broadly appealing to their diverse students. We begin with the notion of Pedagogical Design Capacity, which describes a dynamic relationship between teachers and their tools and the ability for teachers to perceive and leverage affordances of artifacts as tools in …

Board Of Regents Meeting Materials, October 25, 2019, Eastern Michigan University

Board of Regents Meeting Materials

No abstract provided.

Drought Impacts And Management In Prairie And Sandhills State Parks, Theresa M. Jedd, Devarati Bhattacharya, Cara Pesek, Michael J. Hayes

National Oceanographic and Atmospheric Administration: Technical Reports and Related Materials

The combination of decreased water availability and increased temperatures can interfere with outdoor activities, particularly with surface water decline and the increased risk of wildfire. Drought is a longer-term climate trend, but there is a tendency toward short-term reactions only when a drought occurs. Policy mechanisms for drought, where present, are often left to managerial discretion because they are not needed every year, and lack specific indicators. Recreator choices contribute to adaptation and public lands managers also shape drought response by monitoring meteorological trends and managing resources wisely. Despite these trends, no singular recreational drought definition exists. To understand socio-environmental …

Drought Impacts And Management In Prairie And Sandhills State Parks, Theresa M. Jedd, Devarati Bhattacharya, Cara Pesek, Michael J. Hayes

National Oceanographic and Atmospheric Administration: Technical Reports and Related Materials

The combination of decreased water availability and increased temperatures can interfere with outdoor activities, particularly with surface water decline and the increased risk of wildfire. Drought is a longer-term climate trend, but there is a tendency toward short-term reactions only when a drought occurs. Policy mechanisms for drought, where present, are often left to managerial discretion because they are not needed every year, and lack specific indicators. Recreator choices contribute to adaptation and public lands managers also shape drought response by monitoring meteorological trends and managing resources wisely. Despite these trends, no singular recreational drought definition exists. To understand socio-environmental …

The Effects Of In Utero Levothyroxine Exposure On Anterior-Posterior Craniofacial Development In A Mouse Model, Ashley Rogers Albrecht

MUSC Theses and Dissertations

Introduction: The purpose of this study was to investigate the effects of in utero levothyroxine exposure on anterior-posterior craniofacial development in a mouse model. Methods: In order to determine the effects of in utero levothyroxine exposure on anterior-posterior craniofacial development, a study group (n=19) of C57BL6 mice were exposed to high dose (~667ng per day) levothyroxine during fetal development. Mice were sacrificed day 15 post-natal. Skulls were fixed in a solution of 4% paraformaldehyde, then switched to 70% ethanol in preparation for microCT imaging. Scans were loaded into Dolphin Imaging Software and lateral cephalograms were rendered and analyzed. Results: According …

The Upper-Airway Microbiota And Loss Of Asthma Control Among Asthmatic Children, Yanjiao Zhou, Leonard B. Bacharier, Mario Castro, Gregory A. Storch, Kristine Wylie, Avraham Beigelman, Et Al.

Open Access Publications

No abstract provided.

Melanism As A Potential Thermal Benefit In Eastern Fox Squirrels (Sciurus Niger), Amanda K. Ciurej, Ashley Oblander, Andrew W. Swift, James A. Wilson

United States Fish and Wildlife Service: Publications

Melanistic fox squirrels (Sciurus niger) have expanded westward and increased in frequency in the Omaha, Nebraska, and Council Bluffs, Iowa, metropolitan areas. The selective advantage of melanism is currently unknown, but thermal advantages have been hypothesized, especially in winter. No difference in metabolic response curves were measured between melanistic (black) and rufus (orange) fox squirrels. When exposed to sunny skies, both melanistic and rufus squirrels had higher surface (skin and fur) temperature as ambient temperatures increased. Melanistic squirrel surface temperatures did not differ when squirrels were exposed to sunny or cloudy skies. However, rufus individuals showed significantly lower …

Multifocal Necrotizing Myopathy In Northern Elephant Seal (Mirounga Angustirostris) Pups, San Miguel Island, California, Terry R. Spraker, Tetiana A. Kuzmina, Eugene T. Lyons, Robert L. Delong, Claire Simeone, D. N. Rao Veeramachaneni

United States Department of Commerce: Staff Publications

A field study addressing causes of mortality in freshly dead northern elephant seals (Mirounga angustirostris, Gill, 1866) was conducted on San Miguel Island, California, in February 2015. Necropsies were performed on 18 pups ranging in age from stillbirths to approximately 7 to 8 weeks. The primary gross diagnoses in these pups included trauma, myopathy, starvation/ emaciation, infections, congenital anomalies, and perinatal mortality. However, 6 (33%) had a previously unrecognized myopathy characterized by multiple white streaks that were most obvious within the inner layer of the abdominal wall and the small innermost ventral intercostal muscles. Following histological examination, 2 …

Cdek: Clinical Drug Experience Knowledgebase, Rebekah H Griesenauer, Constantino Schillebeeckx, Michael S Kinch

2010-2019 OA Pubs

The Clinical Drug Experience Knowledgebase (CDEK) is a database and web platform of active pharmaceutical ingredients with evidence of clinical testing as well as the organizations involved in their research and development. CDEK was curated by disambiguating intervention and organization names from ClinicalTrials.gov and cross-referencing these entries with other prominent drug databases. Approximately 43% of active pharmaceutical ingredients in the CDEK database were sourced from ClinicalTrials.gov and cannot be found in any other prominent compound-oriented database. The contents of CDEK are structured around three pillars: active pharmaceutical ingredients (n = 22 292), clinical trials (n = 127 223) and organizations …

Novel Amphiphilic Cyclobutene And Cyclobutane Cis-C18 Fatty Acid Derivatives Inhibit Mycobacterium Avium Subsp. Paratuberculosis Growth, Denise K. Zinniel, Wantanee Sittiwong, Darrell D. Marshall, Govardhan Rathnaiah, Isin T. Sakallioglu, Robert Powers, Patrick H. Dussault, Raul G. Barletta

School of Veterinary and Biomedical Sciences: Faculty Publications

Mycobacterium avium subspecies paratuberculosis (Map) is the etiologic agent of Johne’s disease in ruminants and has been associated with Crohn’s disease in humans. An effective control of Map by either vaccines or chemoprophylaxis is a paramount need for veterinary and possibly human medicine. Given the importance of fatty acids in the biosynthesis of mycolic acids and the mycobacterial cell wall, we tested novel amphiphilic C₁₀ and C₁₈ cyclobutene and cyclobutane fatty acid derivatives for Map inhibition. Microdilution minimal inhibitory concentrations (MIC) with 5 or 7 week endpoints were measured in Middlebrook 7H9 base broth media. We compared the …

Investigation Of Congestive Heart Failure In Beef Cattle In A Feedyard At A Moderate Altitude In Western Nebraska, Rodney A. Moxley, David R. Smith, Dale M. Grotelueschen, Tom Edwards, David Steffen

School of Veterinary and Biomedical Sciences: Faculty Publications

Right-sided congestive heart failure (brisket disease) commonly occurs in cattle raised at elevations >2,500– 3,500 m. We investigated clinical cases resembling brisket disease at a western Nebraska feedyard at a moderate altitude (1,369 m). Over a 15-mo period (2009–2010), we examined 17 cases (16 steers and 1 heifer), all purebred Angus. All animals had clinical right-sided heart failure: brisket and ventral abdominal edema, and severe chronic passive congestion of the liver. Gross examination confirmed right ventricular hypertrophy (left ventricle plus septum: right ventricle weight ratio mean: 1.33 vs. 2.8–4.0 reference interval). Microscopically, all 17 cases had interstitial fibrosis (mean score: …

Droughtscape, Winter 2019, National Drought Mitigation Center

DroughtScape: Quarterly Newsletter of the National Drought Mitigation Center (2007–2023)

Contents

From the Director

Drought intensified in California and Nevada, eased elsewhere

Year in Review: Drought spread and intensified in the West; record precipitation in the East

Drought impact summary for 4th quarter 2018

Drought impact summary 2018

Five states began drought plan updates in 2018

New web-based form makes submitting drought observations easier

FEMA risk assessment process tailored for drought

Upcoming events

Thymic Expression Of Il-4 And Il-15 After Systemic Inflammatory Or Infectious Th1 Disease Processes Induce The Acquisition Of"Innate" Characteristics During Cd8 + T Cell Development, Natalia S. Baez, Fabio Cerbán, Constanza Savid-Frontera, Deborah L. Hodge, Jimena Tosello, Eva Acosta-Rodriguez, Laura Almada, Adriana Gruppi, Maria Estefania Viano, Howard A. Young, Maria Cecilia Rodriguez-Galan

United States Public Health Resources

Innate CD8 + T cells express a memory-like phenotype and demonstrate a strong cytotoxic capacity that is critical during the early phase of the host response to certain bacterial and viral infections. These cells arise in the thymus and depend on IL-4 and IL-15 for their development. Even though innate CD8 + T cells exist in the thymus of WT mice in low numbers, they are highly enriched in KO mice that lack certain kinases, leading to an increase in IL-4 production by thymic NKT cells. Our work describes that in C57BL/6 WT mice undergoing a Th1 biased infectious disease, …

On Cluster Robust Models, José Bayoán Santiago Calderón

CGU Theses & Dissertations

Cluster robust models are a kind of statistical models that attempt to estimate parameters considering potential heterogeneity in treatment effects. Absent heterogeneity in treatment effects, the partial and average treatment effect are the same. When heterogeneity in treatment effects occurs, the average treatment effect is a function of the various partial treatment effects and the composition of the population of interest. The first chapter explores the performance of common estimators as a function of the presence of heterogeneity in treatment effects and other characteristics that may influence their performance for estimating average treatment effects. The second chapter examines various approaches …

Mobile Societies, Mobile Religions: On The Ecological Roots Of Two Religions Deemed Monotheistic, Edward Surman

CGU Theses & Dissertations

How do environments affect the generation and development of religions? The investigation taken up in this dissertation is one attempt to address this question. This work focuses on one comparative case study: the potential causal relationship between agriculturally marginal landscapes and the two oldest religions deemed monotheistic. This dissertation argues that the respective origins (and early development) of communities of worship centered around Ahura Mazda and YHWH were affected by similar environmental contexts. The dearth of literature concerning the effects of environments on religions extends to established theoretical and methodological approaches on the topic. The framework for approaching this research …

Nsu Student Handbook 2019-2020, Nova Southeastern University

College of Engineering and Computing Course Catalogs

No abstract provided.

General Isochronous Rhythm In Echolocation Calls And Social Vocalizations Of The BatSaccopteryx Bilineata, Lara S. Burchardt, Philipp Norton, Oliver Behr, Constance Scharff, Mirjam Knörnschild

KIP Articles

Rhythm is an essential component of human speech and music but very little is known about its evolutionary origin and its distribution in animal vocalizations. We found a regular rhythm in three multisyllabic vocalization types (echolocation call sequences, male territorial songs and pup isolation calls) of the neotropical bat Saccopteryx bilineata . The intervals between element onsets were used to fit the rhythm for each individual. For echolocation call sequences, we expected rhythm frequencies around 6–24 Hz, corresponding to the wingbeat in S. bilineata which is strongly coupled to echolocation calls during flight. Surprisingly, we found rhythm frequencies between 6 …

A Descriptive Study Of The Faber Series Piano Adventures And Its Implications For Piano Pedagogy, Martha Frances Monroe

Electronic Theses and Dissertations

The purpose of this study is to examine the Piano Adventures method books written by Randall and Nancy Faber. The series was thoroughly researched and developed for ten years before it was published in 1993. Since that time, the series has been enhanced and has added numerous additional books of repertoire, technique, and improvisation. An online application has been created to help not only students, but also to provide teaching tools and guides for teachers. With the inclusion of technology at the forefront of all education, the Faber series has opened the door for students through a new approach that …