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Alda-1 Attenuates Hyperoxia-Induced Mitochondrial Dysfunction In Lung Vascular Endothelial Cells, Sahebgowda Sidramagowda Patil, Helena Hernández-Cuervo, Jutaro Fukumoto, Venkata Ramireddy Narala, Smita Saji, Monica Borra, Matthew Alleyn, Muling Lin, Ramani Soundararajan, Richard Lockey, Narasaiah Kolliputi, Lakshmi Galam

Internal Medicine Faculty Publications

Acute lung injury (ALI) is a major cause of morbidity and mortality worldwide, especially in aged populations. Mitochondrial damage is one of the key features of ALI. Hyperoxia-induced lung injury model in mice has been widely used for ALI study because it features many ALI phenotypes including, but not limited to, mitochondrial and vascular endothelial cell damage. Recently, accumulating evidence has shown that mitochondrial aldehyde dehydrogenase 2 (ALDH2) has a protective effect against oxidative stress mediated cell damage in epithelial cells. However, it is not known whether ALDH2 protects against oxidative stress in vascular endothelial cells. In this current study, …

The Impact Of Yiv-906 On Progression-Free Survival, Health-Related Quality Of Life And Metabolites Of Patients With Metastatic Colorectal Cancer, Jinqi Zhan

Public Health Theses

Abstract

Cancer is one of the leading causes of death in the world, and chemotherapy plays an important role in cancer treatment. However, serious adverse effects of chemotherapy could jeopardize the efficacy of the treatment as well as patients’ quality of life. In order to remit this problem, a well-characterized herbal medicine, YIV-906 (KD018/PHY906), was developed as a combination therapy with chemotherapy. It is based on a traditional Chinese herbal formulation (Huang-Qin-Tang) that treats diseases related to gastrointestinal disorders and was investigated in a two-arm clinical trial for metastatic colorectal cancer (mCRC). A previous analysis done by Sun et al. …

A Case Of Allergic Bronchopulmonary Aspergillosis (Abpa) In A Patient With A History Of Cocaine Use And Tuberculosis, Noura Ayoubi, Samuel Jalali, Nikesh Kapadia

Internal Medicine Faculty Publications

Aspergillosis refers to a spectrum of disorders that can occur due to colonization with the Aspergillus fungus. Allergic bronchopulmonary aspergillosis (ABPA) is an airway hypersensitivity reaction to the fungus that is almost exclusively seen in patients with cystic fibrosis or asthma. Here, we present a case of ABPA in a patient with a history of chronic cocaine use and tuberculosis and no history of asthma or cystic fibrosis. The patient had presented with progressively worsening dyspnea for three months as well as a 20-pound weight loss. Diagnosis was made with an elevated IgE against Aspergillus and chest CT findings, which …

Moral Restorative Justice: A Political Genealogy Of Activism And Neoliberalism In The United States, Amy J. Cohen

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

Regime Congruence: Rethinking The Scope Of State Responsibility For Transboundary Environmental Harm, Maria L. Banda

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

The Too Big To Fail Problem, Saule T. Omarova

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

Religious Exemptions And Lgbtq Child Welfare, Jordan Blair Woods

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

Congress's Agency Coordination, Bijal Shah

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

Sanctuary Networks, Rose Cuison Villazor, Pratheepan Gulasekaram

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

Environmental Standards, Thresholds, And The Next Battleground Of Climate Change Regulations, Kimberly M. Castle, Richard L. Revesz

Minnesota Law Review, Vols. 1-106:1 (1917-2021)

No abstract provided.

How New Zealand’S Adoption Of The Nagoya Protocol Would Enhance Protection Of Māori Traditional Knowledge, Emily Ortlieb Ricciardi

Minnesota Journal of International Law, Vols 1-28:1 (1992-2019)

No abstract provided.

Exploring Mechanisms Of Persistent Cognitive Deficits In Mice With Transient Hyperhomocysteinemia, Reeya Khanal

Neuroscience Scholars Theses

Hyperhomocysteinemia (Hhcy) has been found in the elderly and is considered a risk factor for several neurological diseases, especially Alzheimer’s and Vascular Dementia. Previous studies have found an increase in Blood-Brain Barrier (BBB) leakage, glial activation, neuronal damage, and cognitive deficit with elevated levels of plasma homocysteine. Lowering homocysteine could be an easy and inexpensive way to reduce the risk of dementia. But it is still not known for sure if reducing plasma homocysteine levels can recover cognitive function. In our transient Hhcy model, 28 mice were given Hhcy inducing or nutritionally matched control diet for 8 weeks and then …

A Role For Regional Science In Analyzing Water Issues, Christa D. Court, Elham Erfanian

Regional Research Institute Working Papers

The World Economic Forum has consistently ranked water crises as one of the top five most impactful issues facing humanity, alongside but not completely separate from issues such as climate change and natural disasters (World Economic Forum, 2019). A growing population and changing climate will only further stress the constrained water system. Acute and ongoing societal disruptions, caused by significant declines in the available quality and quantity of fresh water around the globe, underscore the importance of water to human life and a functional society. The papers in this special issue highlight the role that regional scientists can and should …

'A Room Of Their Own': Heritage Tourism And The Challenging Of Heteropatriarchal Masculinity In Scottish National Narratives, Carys O'Neill

Electronic Theses and Dissertations

This thesis explores the visibility of women in traditionally masculine Scottish national narratives as evidenced by their physical representation, or lack thereof, in the cultural heritage landscape. Beginning with the 1707 Act of Union between Scotland and England, a moment cemented in history, literature, and popular memory as the beginning of a Scottish rebirth, this thesis traces the evolution of Scottish national identity and the tropes employed for its assertion to paint a clearer picture of the power of strategic selectivity and the effects of sacrifice in the process of community definition. Following the transformation of the rugged Celtic Highlander …

Basic Turbo Roundabouts As An Alternative To Conventional Double-Lane Roundabouts: Operational Performance Evaluation, Zuhair Elhassy

Electronic Theses and Dissertations

Conventional roundabouts have been prevalent worldwide since the emergence of modern roundabouts in 1966. An innovative design of multilane roundabouts known as turbo roundabouts, however, has been recently introduced as an alternative to conventional multilane roundabouts. Due to several reasons, there has been no general consensus on the operational performance of turbo roundabouts throughout the world. Nationwide, turbo roundabouts have yet to be part of roadway systems, but there is an ongoing project expected to be finished in early 2020. Therefore, this dissertation aims to evaluate the operational performance of a widespread variant of turbo roundabouts, namely basic turbo roundabouts, …

Physical-Virtual Patient Simulators: Bringing Tangible Humanity To Simulated Patients, Salam Daher

Electronic Theses and Dissertations

In lieu of real patients, healthcare educators frequently use simulated patients. Simulated patients can be realized in physical form, such as mannequins and trained human actors, or virtual form, such as via computer graphics presented on two-dimensional screens or head-mounted displays. Each of these alone has its strengths and weaknesses. I introduce a new class of physical-virtual patient (PVP) simulators that combine strengths of both forms by combining the flexibility and richness of virtual patients with tangible characteristics of a human-shaped physical form that can also exhibit a range of multi-sensory cues, including visual cues (e.g., capillary refill and facial …

Nanoscale Functional Imaging By Tailoring Light-Matter Interaction To Explore Organic And Biological Systems, Negar Otrooshi

Electronic Theses and Dissertations

Probing molecular systems with light has been critical to deepen our understanding of life sciences. However, conventional analytical methods fail to resolve small quantities of molecules or the heterogeneity in molecules assembled into complex systems. This bottleneck is mostly attributed to light diffraction limit. In recent years, the successful implementation of new approaches to achieve sub-wavelength chemical speciation with an Atomic Force Microscope (AFM) has paved the way to a deeper understanding of the effect of local composition and structure on the functional properties of a larger scale system. The combination of infrared light, to excite the vibrational modes of …

Applications Of Gis To Natural Resource Management: Gsu Field Station And Surrounding Thorn Creek Preserve, Jeegarkumar Panchal

All Capstone Projects

Geographic Information System is used to identify available natural resources and their management of Governors State University and surrounding Thorn Creek Preserve. Using ArcGIS 10.5.1, seven different map have been made categorized under, Governors State University campus map, land use types of the study area, available streams and ponds, major ground water resources in this area, human population dynamics, digital elevation model and soil type of the study area. The GPS points have been recorded using GPS unit. The available GIS data shape files have been collected from Illinois Natural Resource Geographical Data Clearinghouse. The Governors State University campus map …

Journal Of The Arkansas Academy Of Science - Volume 73, 2019, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

Energy Content Of Seeds Of Texas Doveweed (Croton Texensis) From The Diet Of Mourning Doves (Zenaida Macroura) From Southeastern New Mexico, John L. Hunt, Matthew E. Grilliot, Troy L. Best, Collin S. Deen, Dixie Lozano-Lopez, Emily R. Neilson, Taytumn R. Schlegel-Ridgway

Journal of the Arkansas Academy of Science

We analyzed the energy content of seeds of Texas doveweed (Croton texensis) obtained from the crops of mourning doves (Zenaida macroura) collected from plains-mesa sand-scrub habitat in Eddy and Lea counties, New Mexico. Seeds were removed from crops and dried for 48 hours at 60°C to remove moisture and to standardize masses. Seeds were then analyzed for gross caloric value (i.e., energy content) in an oxygen bomb calorimeter. Energy content of seeds of Texas doveweed was greater than many seeds previously reported from the diet of mourning doves.

Vertebrate Natural History Notes From Arkansas, 2019, C. Renn Tumlison, Chris Mcallister, Henry Robison, Matt Connior, Ron Redman, Stan Trauth, Paul Port

Journal of the Arkansas Academy of Science

Important observations of natural history often go unreported because they are not part of larger studies, but small details can provide insights that lead to interesting questions about ecological relationships or environmental change. We have compiled recent important observations of distribution, deformities, foods, parasites, and reproduction of various vertebrates. Included are a new record of Lake Sturgeon (Acipenser fulvescens), a new size record of mudpuppy (Necturus louisianensis), and a second observation of bilateral gynandromorphism in a Northern Cardinal (Cardinalis cardinalis). These unique observations continue to grow knowledge of vertebrate biology in Arkansas.

History And Current Status Of The Inca Dove (Columbina Inca) In Arkansas, Ragupathy Kannan, Jack Jackson, Ethan Brooks

Journal of the Arkansas Academy of Science

Formerly a bird of Central America, Mexico, and the southwestern United States, the Inca Dove (Columbina inca) has been expanding northward across North America in the past few decades. It first appeared in Arkansas on October 26, 1968 in Saratoga, Howard County. Since then, the statewide range has grown to include at least 36 of 75 counties and is expanding. With the use of Christmas Bird Counts, Breeding Bird Surveys, and two citizen science sources, eBird and AR-Birds, we compiled 368 records of the species in the state. Inca Doves were observed year-round in Arkansas and are expanding …

Long-Tailed Weasel (Mustela Frenata) Distribution Survey In Arkansas: Challenges In Detecting A Rare Species, Suzanne D. Johnston, D. Blake Sasse, Robert E. Kissell Jr.

Journal of the Arkansas Academy of Science

Long-tailed weasels (Mustela frenata) have one of the widest distributions of mustelids in the western hemisphere and were distributed across a majority of the American continents ranging from Canada through the contiguous United States, Mexico, and into northern South America. However, on a local scale they are considered uncommon and rare. We assessed the distribution of long-tailed weasels across Arkansas to determine occupancy in each ecoregion of Arkansas, and determined the detectability on two local, adjacent sites. No long-tailed weasels were detected within the ecoregions, but the species was detected with intensive sampling on one local site. It …

A Tale Of Two Sylamores: Understanding Relationships Among Land Use, Nutrients, And Aquatic Communities Across A Subsidy-Stress Gradient, Danielle Braund, Andrew Feltmann, George Gavrielides, Katherine Lang, Jennifer Main, Anastasia Mogilevski, Justin Mosbey, Rebecca Relic, Calvin Rezac, Brianna Trejo, Ginny Adams, Steven R. Adams

Journal of the Arkansas Academy of Science

Agricultural land use is known to degrade aquatic systems with high inputs of nutrients, sediments, and pesticides. Increased nutrients can lead to increased algal growth and thus possible hypoxic conditions in slow moving water, while increased sediment loads have been shown to obstruct light and reduce substrate stability. These conditions negatively impact primary producers, macroinvertebrates, and fish. However, small-scale changes in land use can subsidize an aquatic ecosystem instead, where an increase in nutrients allows nutrient-limited biota to flourish, and minor increases in sedimentation may help support populations of collector-filterers. The stimulation in performance caused by small disturbances is part …

Plains Spotted Skunk Pelt Purchase Trends In The Ozarks And Ouachitas, 1943-1990, D. Blake Sasse

Journal of the Arkansas Academy of Science

The Plains spotted skunk (Spilogale putorius interrupta) is a small carnivore that has experienced population declines across much of its range and is currently being considered for listing as an endangered species. I utilized harvest data on pelts from the Ozarks of Missouri and Arkansas and the Ouachita mountains in Arkansas that were purchased by fur dealers from 1943-1990 to examine trends in harvest levels over time. Purchases in all three regions declined in the late 1940s and early 1950s, but purchases in the Arkansas returned to near or at historic levels in the early 1960s and the …

Bilateral Diaphyseal Chondrodysplasia And Polymorphic Osteodysplasia Of The Tibiofibulas In A Southern Leopard Frog, Lithobates Sphenocephalus (Amphibia: Anura: Ranidae), Stanley E. Trauth, Malcolm L, Mccallum

Journal of the Arkansas Academy of Science

Much attention has been focused on limb malformations in anurans following the startling discovery of major limb deformities in Northern Leopard Frogs (Rana pipiens) in Minnesota in 1995. The numerous causes for these malformations can be attributed to a number of natural phenomena, or they can be considered as being manmade. In the present study, we report on a previously undescribed type of limb abnormality in a single individual of the Southern Leopard Frog (Lithobates sphenocephalus) from Arkansas. Histological examination of left tibiofibula revealed a complete disruption of the normal diaphyseal bone structure in this adult …

Haemogregarina Sp. (Apicomplexa: Eucoccidiorida: Adeleorina) From Eastern Spiny Softshell, Apalone Spinifera Spinifera (Testudines: Trionychidae), From Arkansas, Chris T. Mcallister, Henry W. Robison

Journal of the Arkansas Academy of Science

No abstract provided.

Instructions To Authors, Academy Editors

Journal of the Arkansas Academy of Science

No abstract provided.

The Influence Of Household Chaos And The Home Language Environment On Preschool-Age Children’S School Readiness, Laura Mary Northerner

Wayne State University Dissertations

School readiness, including both cognitive and social-emotional development, is an important indicator of a child’s preparedness for school entry, and a meaningful predictor of future academic success (Duncan et al., 2007). The home environment plays a critical role in the development of children’s school readiness, especially for children facing social inequalities. Within the home environment, household chaos and home language have been found to impact school readiness. The current study expanded on previous research on household chaos by collecting multiple measures of household chaos, including a naturalistic observation across several days. The current study also naturalistically investigated the home language …

To Be Or Not To Be: Examining The Role Of Language In A Concept Of Negation, Ann E. Nordmeyer, Jill De Villiers

Philosophy: Faculty Publications

Negation is a complex, abstract concept, despite the ubiquity of words like “no” and “not” in even young children’s speech. One challenging aspect to words like “no” and “not” is that these words can serve many functions in speech, giving us tools to express an array of concepts such as denial, refusal, and nonexistence. Is there a single concept of “negation” that unites these separate negative functions – and if so, does understanding this concept require the structure of human language? In this paper we present a study demonstrating that adults spontaneously identify a concept of negation in the absence …