Digital Commons Network^™

Race, Slavery And Justice: A Justice System Case Study, Camille Cameron

Reports & Public Policy Documents

We do not have to look far today in Canada to see the legacies of slavery in their full effect. One of these legacies is the way in which we have chosen to forget slavery, or perhaps to deny it, and to create a different narrative. “Slavery is Canada’s best-kept secret, locked within the national closet,” asserts Afua Cooper. Ask many Canadians about the history of slavery in Canada and they will talk about the Underground Railroad. This is what many of us learned in school, that slavery existed in America, not in Canada, and that Canada’s heroic, romantic role …

Filling The Gaps: Common Bottlenose Dolphin (Tursiops Truncatus) Population Dynamics, Structure, And Connectivity Within Florida Panhandle Bays, Sounds, And Estuaries, Christina Toms

Electronic Theses and Dissertations

At the time of the Deepwater Horizon oil spill in 2010, very little was known about the inshore bottlenose dolphin (Tursiops truncatus) populations hit hardest by the spill. Without previous population demographic data impacts were challenging to assess. My dissertation was designed to build research capacity moving forward by helping to fill data gaps in the western Florida Panhandle. The first study presented here resulted in the first system-wide assessment of seasonal abundance, survival, and site fidelity patterns of bottlenose dolphins that inhabit the Pensacola Bay system. In contrast to a previous study that reported only 33 dolphins, results from …

The Role Of Nrf2 Signalling In Cell Proliferation And Tumorigenesis Of Chromium Transformed Human Bronchial Epithelial Cells, Marco Antonio De Freitas Clementino

Theses and Dissertations--Toxicology and Cancer Biology

Hexavalent Chromium (Cr(VI) induces malignant cell transformation in normal bronchial epithelial (BEAS-2B) cells. Cr(VI)-transformed cells exhibit increased level of antioxidants, are resistant to apoptosis, and are tumorigenic. RNAseq analysis in Cr(VI)-transformed cells showed that expression of transcripts associated with mitochondrial oxidative phosphorylation is reduced, and the expression of transcripts associated with pentose phosphate pathway, glycolysis, and glutaminolysis are increased. Sirtuin-3 (SIRT3) regulates mitochondrial adaptive response to stress, such as metabolic reprogramming and antioxidant defense mechanisms. SIRT3 was upregulated and it positively regulated mitochondrial oxidative phosphorylation in Cr(VI)-transformed cells. Our results suggests that SIRT3 plays an important role in mitophagy deficiency …

A Compromised Liver Alters Pcb Toxicity And Nutrient Metabolism, Jazmyne D. L. Barney

Theses and Dissertations--Toxicology and Cancer Biology

Environmental contamination is a public health concern. In particular persistent organic pollutants like Polychlorinated Biphenyls (PCBs) have been associated with multiple chronic inflammatory diseases, including non-alcoholic fatty liver disease (NAFLD). NAFLD prevalence has steadily increased and is expected to continue to rise with an estimated 25% of the world’s population and 80-100 million people affected in the United States alone. Importantly, the liver is the primary site for endobiotic and xenobiotic metabolism, hence its proper function is critical for the body’s response to innate and extrinsic molecules. One way to combat the deleterious effects of PCB toxicity and fatty liver …

The Old Man & The Mouse, Jenny Charest

Library Creative Writing Contest

Jenny Charest’s debut short story, The Old Man & the Mouse, is a dark tale of a widower and his experience with a supernatural infestation that embraces elements of afterlife and karma.

Surviving Climate Change In America: Toward A Rural Resilience Framework, Laurie Ristino

Western New England Law Review

This Article argues that rural America—a land mass encompassing the majority of the nation and the locus of much of our ecosystem services, including the provisioning of food and water—is critical to our nation’s survival and prosperity in the climate change era. Further, this Article posits a key role for rural Americans as stewards of those resources and producers of food and fiber. Given the environmentally and economically compromised state of rural America, this Article proposes using the concept of resilience as the foundation of a framework to guide social investments and policy efforts to better address our economic and …

Criminal Law/Constitutional Law—Article 26 Of The Massachusetts Declaration Of Rights: The Supreme Judicial Court’S “Cruel” And “Unusual” Neglect Of Its Longevity Component, Thomas H. Townsend

Western New England Law Review

Article 26 of the Massachusetts Declaration of Rights, which prohibits “cruel or unusual punishments,” is arguably broader in scope than its federal counterpart, the Eighth Amendment to the United States Constitution. In addressing constitutional challenges to the length of incarceration sentences, the Massachusetts Supreme Judicial Court utilizes essentially the same test under Article 26 as the United States Supreme Court does under the Eighth Amendment. Among other considerations, the tests compare the subject sentence of a crime to the potential sentences for more serious crimes within the same jurisdiction, as well as to the prescribed sentences for the same crime …

The Costs Of Climate Disruption In The Trade-Offs Of Community Resilience, Keith H. Hirokawa, David Dickinson

Western New England Law Review

Wetlands perform certain functions, including water filtration and the provision of wildlife habitats, from which humans benefit in the form of drinkable water and biodiversity. Trees produce oxygen, capture air and water pollutants, and provide shade, which help humans breathe, manage storm waters, and find a comfortable place to relax on a hot day. These are services that are provided by functioning ecosystems and are measured through the ecological economics of ecosystem services. The study of ecosystem services has provided an important insight: for the most part, those very services are ignored or undervalued. Although humans derive enormous benefits from …

Foreword—Anthropocenic Disruption, Community Resilience And Law, René Reich-Graefe

Western New England Law Review

Since the First Agricultural (or Neolithic) Revolution, humans have been the primary agents of both biospheric and sociospheric change. Modern human societies evolved in an ecosystem of abundance in which human agency and consumption could conveniently ignore the problem of natural capital. At today’s peak of humanity, first-world humans personally produce virtually nothing to sustain their respective individual lives. Instead, distant agro-industrial systems and global economies of scale mass-produce the resources that modern humans simply acquire through, often anonymous, exchange transactions in order to satisfy their survival and welfare needs. By the second half of the twenty-first century, the Anthropocene …

Transcript—Complex Reciprocity In A Local Food System, Sarah Waring

Western New England Law Review

During the Western New England Law Review’s October 2019 symposium on Anthropocenic Disruption, Community Resilience and Law, Sarah Waring, the Vice President for Grants and Community Investments at the Vermont Community Foundation, gave a presentation on local place-based food systems and the powerful impact they have in combating the anthropocenic disruption we face at-large. Community is complicated. And yet, the ability to self-organization and innovate relies to a large extent on the relational strength of the community. Working within a small rural region, and focusing on place-based food systems, the growing importance of relational strength within community …

Transcript—Kitchen Tables, Board Rooms, And Other Potentially Disruptive Locales: The Role Of Consumer Action In Carbon Emission Reduction, Elizabeth A. Stanton

Western New England Law Review

During the Western New England Law Review’s October 2019 symposium on Anthropocenic Disruption, Community Resilience and Law, Elizabeth A. Stanton, the Director and Senior Economist at the Applied Economic Clinic, gave a presentation that analyzed the overall impact that consumers and businesses have, in their everyday decisions, with respect to climate change and Anthropocenic disruption. In her presentation, she intentionally explores and parses through several questions geared towards underlying the key distinctions between individual consumer choices, known as kitchen table choices, and decisions made by businesses, or board room decisions. Additionally, she pursues a conversation on the …

Direct-To-Consumer Calls To Action: Lowering The Volume Of Claims And Disclosures In Prescription Drug Broadcast Advertisements, Andrew Andrzejewski

Brooklyn Law Review

Pharmaceutical companies advertise drugs directly to consumers via television and radio broadcast commercials, print advertisements, and the internet. Although broadcast advertisements are demonstrably unable to adequately convey risk information, a total ban on them would be too restrictive, and any regulation targeting these advertisements must withstand First Amendment scrutiny. The FDA’s recent attempts to modify its requirements for broadcast advertisements do not overcome these challenges. It is in the best interest of patients, doctors, the drug industry, and the government for Congress to authorize the FDA to regulate broadcast drug advertisements as limited calls to action, consisting of restricted product …

Gillick Competence: An Unnecessary Burden, Nigel Zimmermann

Arts Papers and Journal Articles

This study of the implications of Gillick competence argues it is an unnecessary burden with an unethical foundation. The ethics of adolescent medical decision-making is a fraught area for medical ethics because it deals with the threshold boundaries between childhood and adulthood and Gillick adds a burden upon children and adolescent patients that is unwarranted and through which damage is done to integral human relationships. In light of Gillick, it can be seen that the context of adolescent decision-making and childhood, is a neglected topic of ethical reflection.

The Arkema Chemical Facility Incident: How The Regulation Of Reactive Chemicals And The Incorporation Of Climate Change Risks In Emergency Response Planning Could Mitigate And Prevent Future Accidental Chemical Releases, Lauren Mulhern

Colorado Environmental Law Journal

No abstract provided.

The Complex Affective Scene Set (Compass): Solving The Social Content Problem In Affective Visual Stimulus Sets, Mariann R. Weierich, Olena Kleshchova, Jenna Rieder K. Rieder, Danielle M. Reilly

College of Humanities and Sciences Faculty Papers

Social information, including faces and human bodies, holds special status in visual perception generally, and in visual processing of complex arrays such as real-world scenes specifically. To date, unbalanced representation of social compared with nonsocial information in affective stimulus sets has limited the clear determination of effects as attributable to, or independent of, social content. We present the Complex Affective Scene Set (COMPASS), a set of 150 social and 150 nonsocial naturalistic affective scenes that are balanced across valence and arousal dimensions. Participants (n = 847) rated valence and arousal for each scene. The normative ratings for the 300 …

Minimal Information For Studies Of Extracellular Vesicles 2018 (Misev2018): A Position Statement Of The International Society For Extracellular Vesicles And Update Of The Misev2014 Guidelines, Clotilde Théry, Kenneth W. Witwer, Elena Aikawa, Maria Jose Alcaraz, Johnathon D. Anderson, Ramaroson Andriantsitohaina, Anna Antoniou, Tanina Arab, Fabienne Archer, Georgia K. Atkiin-Smith, D. Craig Ayre, Jean-Marie Bach, Daniel Bachurski, Hossein Baharvand, Leonora Balaj, Shawn Baldacchino, Natalie N. Bauer, Amy A. Baxter, Mary Bebawy, Carla Beckham, Apolonija Bedina Zavec, Abderrahim Benmoussa, Anna C. Berardi, Paolo Bergese, Ewa Bielska, Cherie Blenkiron, Sylwia Bobis-Wozowicz, Eric Boilard, Wilfrid Boireau, Antonella Bongiovanni, Francesc E. Borràs, Steffi Bosch, Chantal M. Boulanger, Xandra Breakefield, Andrew M. Breglio, Meadhbh Á. Brennan, David R. Brigstock, Alain Brisson, Marike L.D. Broekman, Jacqueline F. Bromberg, Paulina Bryl-Górecka, Shilpa Buch, Amy H. Buck, Dylan Burger, Sara Busatto, Dominik Buschmann, Benedetta Bussolati, Edit I. Buzás, James Bryan Byrd, Giovanni Camussi, David R.F. Carter, Sarah Caruso, Lawrence W. Chamley, Yu-Ting Chang, Chichen Chen, Shuai Chen, Lesley Cheng, Andrew R. Chin, Aled Clayton, Stefano P. Clerici, Alex Cocks, Emanuele Cocucci, Robert J. Coffey, Anabela Cordeiro-Da-Silva, Yvonne Couch, Frank A.W. Coumans, Beth Coyle, Rossella Crescitelli, Miria Ferreira Criado, Crislyn D’ Souza-Schorey, Saumya Das, Amrita Datta Chaudhuri, Paola De Candia, Eliezer F. De Santana Junior, Olivier De Wever, Hernando A. Del Portillo, Tanguy Demaret, Sarah Deville, Andrew Devitt, Bert Dhondt, Dolores Di Vizio, Lothar C. Dieterich, Vincenza Dolo, Ana Paula Dominguez Rubio, Massimo Dominici, Mauricio R. Dourado, Tom A.P Driedonks, Filipe V. Duarte, Heather M. Duncan, Ramon M. Eichenberger, Karin Ekström, Samir El Andaloussi, Celine Elie-Caille, Uta Erdbrügger, Juan M. Falcón-Pérez, Farah Fatima, Jason E. Fish, Miguel Flores-Bellver, András Försönits, Annie Frelet-Barrand, Fabia Fricke, Gregor Fuhrmann, Susanne Gabrielsson, Ana Gámez-Valero, Chris Gardiner, Kathrin Gärtner, Raphael Gaudin, Yong Song Gho, Bernd Giebel, Caroline Gilbert, Mario Gimona, Ilaria Giusti, Deborah C.I. Goberdhan, André Görgens, Sharon M. Gorski, David W. Greening, Julia Christina Gross, Alice Gualerzi, Gopal N. Gupta, Dakota Gustafson, Aase Handberg, Reka A. Haraszti, Paul Harrison, Hargita Hegyesi, An Hendrix, Andrew F. Hill, Fred H. Hochberg, Karl F. Hoffmann, Beth Holder, Harry Holthofer, Baharak Hosseinkhani, Guoku Hu, Yiyao Huang, Veronica Huber, Stuart Hunt, Ahmed Gamal-Eldin Ibrahim, Tsuneya Ikezu, Jameel M. Inal, Mustafa Isin, Alena Ivanova, Hannah K. Jackson, Soren Jacobsen, Steven M. Jay, Muthuvel Jayachandran, Guido Jenster, Lanzhou Jiang, Suzanne M. Johnson, Jennifer C. Jones, Ambrose Jong, Tijana Jovanovic-Talisman, Stephanie Jung, Raghu Kalluri, Shin-Ichi Kano, Sukhbir Kaur, Yumi Kawamura, Evan T. Keller, Delaram Khamari, Elena Khomyakova, Anastasia Khvorova, Peter Kierulf, Kwang Pyo Kim, Thomas Kislinger, Mikael Klingeborn, David J. Klinke Ii, Miroslaw Kornek, Maja M. Kosanović, Árpád Ferenc Kovács, Eva-Maria Krämer-Albers, Susanne Krasemann, Mirja Krause, Igor V. Kurochkin, Gina D. Kusuma, Sören Kuypers, Saara Laitinen, Scott M. Langevin, Lucia R. Languino, Joanne Lannigan, Cecilia Lässer, Louise C. Laurent, Gregory Lavieu, Elisa Lázaro-Ibáñez, Soazig Le Lay, Myung-Shin Lee, Yi Xin Fiona Lee, Debora S. Lemos, Metka Lenassi, Aleksandra Leszczynska, Isaac T.S. Li, Ke Liao, Sten F. Libregts, Erzsebet Ligeti, Rebecca Lim, Sai Kiang Lim, Aija Linē, Karen Linnemannstöns, Alicia Llorente, Catherine A. Lombard, Magdalena J. Lorenowicz, Ákos M. Lörincz, Jan Lötvall, Jason Lovett, Michelle C. Lowry, Xavier Loyer, Quan Lu, Barbara Lukomska, Taral R. Lunavat, Sybren L.N. Maas, Harmeet Malhi, Antonio Marcilla, Jacopo Mariani, Javier Mariscal, Elena S. Martens-Uzunova, Lorena Martin-Jaular, M. Carmen Martinez, Vilma Regina Martins, Mathilde Mathieu, Suresh Mathivanan, Marco Maugeri, Lynda K. Mcginnis, Mark J. Mcvey, David G. Meckes, Jr., Katie L. Meehan, Inge Mertens, Valentina R. Minciacchi, Andreas Möller, Malene Møller Jørgensen, Aizea Morales-Kastresana, Jess Morhayim, François Mullier, Maurizio Muraca, Luca Musante, Veronika Mussack, Dillon C. Muth, Kathryn H. Myburgh, Tanbir Najrana, Muhammad Nawaz, Irina Nazarenko, Peter Nejsum, Christian Neri, Tommaso Neri, Rienk Nieuwland, Leonardo Nimrichter, John P. Nolan, Esther N.M. Nolte-’ T Hoen, Nicole Noren Hooten, Lorraine O’Driscoll, Tina O’Grady, Ana O’Loghlen, Takahiro Ochiya, Martin Olivier, Alberto Ortiz, Luis A. Ortiz, Xabier Osteikoetxea, Ole Ostegaard, Matias Ostrowski, Jaesung Park, D. Michiel Pegtel, Hector Peinado, Francesca Perut, Michael W. Pfaffl, Donald G. Phinney, Bartijn C.H. Pieters, Ryan C. Pink, David S. Pisetsky, Elke Pogge Von Strandmann, Iva Polakovicova, Ivan K.H. Poon, Bonita H. Powell, Ilaria Prada, Lynn Pulliam, Peter Quesenberry, Annalisa Radeghieri, Robert L. Raffai, Stefania Raimondo, Janusz Rak, Marcel I. Ramirez, Graça Raposo, Morsi S. Rayyan, Neta Regev-Rudzki, Fran L. Ricklefs, Paul D. Robbins, David D. Roberts, Silvia C. Rodrigues, Eva Rohde, Sophie Rome, Kasper M.A. Rouschop, Aurelia Rughetti, Ashley E. Russell, Paula Saá, Susmita Sahoo, Edison Salas-Huenuleo, Catherine Sánchez, Julie A. Saugstad, Meike J. Saul, Raymond M. Schiffelers, Raphael Schneider, Tine Hiorth Schøyen, Aaron Scott, Eriomina Shahaj, Shivani Sharma, Olga Shatnyeva, Faezeh Shekari, Ganesh Vilas Shelke, Ashok K. Shetty, Kiyotaka Shiba, Pia R-M Siljander, Andreia M. Silva, Agata Skowronek, Orman L. Snyder Ii, Rodrigo Pedro Soares, Barbara W. Sódar, Carolina Soekmadji, Javier Sotillo, Philip D. Stahl, Willem Stoorvogel, Shannon L. Stott, Erwin F. Strasser, Simon Swift, Hidetoshi Tahara, Muneesh Tewari, Kate Timms, Swasti Tiwari, Rochelle Tixeira, Mercedes Tkach, Wei Seong Toh, Richard Tomasini, Ana Claudia Torrecilhas, Juan Pablo Tosar, Vasilis Toxavidis, Lorena Urbanelli, Pieter Vader, Bas W.M. Van Balkom, Susanne G. Van Der Grein, Jan Van Deun, Martijn J.C. Van Herwijnen, Kendall Van Keuren-Jensen, Guillaume Van Niel, Martin E. Van Royen, Andre J. Van Wijnen, M. Helena Vasconcelos, Ivan J. Vechetti Jr., Tiago D. Veit, Laura J. Vella, Émilie Velot, Frederik J. Verweij, Beate Vestad, Jose L. Viñas, Tamás Visnovitz, Krisztina V. Vukman, Jessica Wahlgren, Dionysios C. Watson, Marca H.M. Wauben, Alissa Weaver, Jason P. Webber, Viktoria Weber, Ann M. Wehman, Daniel J. Weiss, Joshua A. Welsh, Sebastian Wendt, Asa M. Wheelock, Zoltán Wiener, Leonie Witte, Joy Wolfram, Angeliki Xagorari, Patricia Xander, Jing Xu, Xiaomei Yan, María Yáñez-Mó, Hang Yin, Yuana Yuana, Valentina Zappulli, Jana Zarubova, Vytautas Žėkas, Jian-Ye Zhang, Zezhou Zhao, Lei Zheng, Alexander R. Zheutlin, Antje M. Zickler, Pascale Zimmermann, Angela M. Zivkovic, Davide Zocco, Ewa K. Zuba-Surma

Department of Cancer Biology Faculty Papers

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines …

Lack Of Truth In Fiction: Frank Norris's Mcteague, Carolyn Payne

Liberal Studies (MA) Final Essays

American author Frank Norris declared in his 1902 essay, Responsibilities of the Novelist, that the writer owed it to the reader to provide him with truth in his storytelling. To quote, “It is not right that they be exploited with false views of life, false characters, false sentiment, false morality, false history…” Yet, only three years earlier Norris published his novel, McTeague: The Story of San Francisco, in which he portrayed characters of various ethnicities as falsely as could be imagined. The characters were written as exaggerated caricatures, defective human beings of lesser races. This essay examines what …

An Assessment Of Biosorption Activated Media For The Removal Of Pollutants In Up-Flow Stormwater Treatment Systems, Andrew Hood

Electronic Theses and Dissertations

Nitrogen and phosphorus are often the limiting nutrients for marine and freshwater systems respectively. Additionally, stormwater often contains elevated levels of pathogens which can pollute the receiving water body and impact reuse applications [1-4]. The reduction of limiting nutrients and pathogens is a common primary target for stormwater best management practices (BMPs) [5]. Traditional BMPs, such as retention/detention treatment ponds require large footprints and may not be practical in ultra-urban environments where above ground space is limited. Upflow filters utilizing biosorption activated media (BAM) that can be placed underground offer a small footprint alternative. Additionally, BAM upflow filters can be …

Development Of In Vitro Point Of Care Diagnostics (Ivpcd) Based On Aptamers Integrated Biosensors, Nileshi Saraf

Electronic Theses and Dissertations

The global market for the medical diagnostic industry is worth 25 billion dollars in the United States and is expected to grow exponentially each year. Presently available methods for biodetection, such as immunoassays, chemiluminescence and fluorescent based assays are expensive, time consuming and require skilled labor with high-end instruments. Therefore, development of novel, passive colorimetric sensors and diagnostic technologies for detection and surveillance is of utmost importance especially in resource constrained communities. The present work focusses on developing novel and advanced in vitro biodiagnostic tools based on aptamer integrated biosensors for an early detection of specific viral proteins or small …

Utilizing Edge In Iot And Video Streaming Applications To Reduce Bottlenecks In Internet Traffic, Kutalmis Akpinar

Electronic Theses and Dissertations

There is a large increase in the surge of data over Internet due to the increasing demand on multimedia content. It is estimated that 80% of Internet traffic will be video by 2022, according to a recent study. At the same time, IoT devices on Internet will double the human population. While infrastructure standards on IoT are still nonexistent, enterprise solutions tend to encourage cloud-based solutions, causing an additional surge of data over the Internet. This study proposes solutions to bring video traffic and IoT computation back to the edges of the network, so that costly Internet infrastructure upgrades are …

Investigation Of Coastal Vegetation Dynamics And Persistence In Response To Hydrologic And Climatic Events Using Remote Sensing, Subrina Tahsin

Electronic Theses and Dissertations

Coastal Wetlands (CW) provide numerous imperative functions and provide an economic base for human societies. Therefore, it is imperative to track and quantify both short and long-term changes in these systems. In this dissertation, CW dynamics related to hydro-meteorological signals were investigated using a series of LANDSAT-derived normalized difference vegetation index (NDVI) data and hydro-meteorological time-series data in Apalachicola Bay, Florida, from 1984 to 2015. NDVI in forested wetlands exhibited more persistence compared to that for scrub and emergent wetlands. NDVI fluctuations generally lagged temperature by approximately three months, and water level by approximately two months. This analysis provided insight …

Coerced Choice: School Vouchers And Students With Disabilities, Claire Raj

Faculty Publications

The landscape of public education, once thought to be a core function of the state, is shifting towards privatization. The appointment of Betsy DeVos as U.S. Secretary of Education further cements this shift. In particular, DeVos intends to vastly expand the availability of vouchers and tax credits that use public dollars to fund private school tuition. The debate over this expansion and its impact on traditional public schools has been polarizing and combative. Thus far, commentators have framed vouchers as purely matters of choice and increased educational opportunities. Drowned out in the debate are the voices of students with disabilities. …

The Staffer's Error Doctrine, Jesse M. Cross

Faculty Publications

Over the last forty years, a new type of legislator has arisen in Congress: one who, rather than drafting statutes, instead manages a staff bureaucracy that produces these statutes. By becoming a manager of bills, not a drafter of them, this new legislator has altered a key relationship in our democracy: that between members of Congress and the laws they enact. Yet no study has documented how this modern relationship works — i.e., has chronicled how today’s federal legislators learn the contents of bills — and thereby shown the modern relationship between legislator and law. Nor has any study reflected …

Equitable Health Savings Accounts, Samuel Estreicher, Clinton G. Wallace

Faculty Publications

This Article offers the first comprehensive legal-policy critique of existing Health Savings Accounts (HSAs), arguing that the current approach is redistributively regressive, thus exacerbating inequality, and also fails to accomplish stated healthcare goals. We propose an alternative—Equitable Health Savings Accounts—which uses cash grants as a tool to address both of these problems. Equitable HSAs are a market-based social program that calibrates size and delivery of a government subsidy to help the least well off and to facilitate participation in healthcare markets. Equitable HSAs can serve as a model for using cash grants to bridge the gap between Republican social policy …

Breaking The Norm Of School Reform, Derek Black

Faculty Publications

No abstract provided.

Cornus Officinalis Significantly Improves Oxidative Capacity And Promotes The Calcium-Dependent Transcription Factor, Nfatc2, In Human 1.1b4 Pancreatic Cell Line, Arielle Sharp, Alexis Coiner, Brant Burkhardt

Molecular Biosciences Faculty Publications

Type 1 diabetes (T1D) is an autoimmune disease resulting in the destruction of pancreatic β cells (β-cells) and subsequent loss of insulin production. The only treatment for T1D is using exogenous insulin coupled with continual glucose monitoring following significant autoimmune destruction of β-cells. Novel interventional therapies are needed that can preserve and protect existing pancreatic β cells in individuals with early identified T1D autoimmunity. Our initial in-vitro evidence indicates Cornus officinalis (CO) may be able to serve in this function. What sets ethnopharmacology apart from conventional medicine is the simultaneous targeting of multiple mechanisms using a single herb due to …

A Ctenophore (Comb Jelly) Employs Vortex Rebound Dynamics And Outperforms Other Gelatinous Swimmers, Brad J. Gemmell, Sean P. Colin, John H. Costello, Kelly R. Sutherland

Integrative Biology Faculty and Staff Publications

Gelatinous zooplankton exhibit a wide range of propulsive swimming modes. One of the most energetically efficient is the rowing behaviour exhibited by many species of schyphomedusae, which employ vortex interactions to achieve this result. Ctenophores (comb jellies) typically use a slow swimming, cilia-based mode of propulsion. However, species within the genus Ocyropsis have developed an additional propulsive strategy of rowing the lobes, which are normally used for feeding, in order to rapidly escape from predators. In this study, we used high-speed digital particle image velocimetry to examine the kinematics and fluid dynamics of this rarely studied propulsive mechanism. This mechanism …

Trade-Offs Shape Carotenoid-Based Color Variation In Redheaded Pine Sawfly (Neodiprion Lecontei) Larvae, Maranda Gaines

Lewis Honors College Capstone Collection

Carotenoids serve various ecological roles in animals including coloration, immune responses, and vision. Carotenoid-derived coloration is greatly emphasized in the literature, particularly relating to mate choice and aposematic warning. However, the trade-offs between the color and non-color functions of carotenoids are not thoroughly explored. In the redheaded pine sawfly (Neodiprion lecontei), some larval populations have yellow pigmentation, using carotenoids derived from their diets for aposematic warning coloration. Other larval populations are white in color, having genetically lost the ability to produce the yellow pigment. Because carotenoids are essential to life functions in both the yellow and white populations, we aim …

A Systematic Review Of Medical Students’ And Professionals’ Attitudes And Knowledge Regarding Medical Cannabis As A Proxy For Forecasting Trends In The Medical Community’S Acceptance Of Therapeutic Hallucinogens, Jared Weisman

Pitzer Senior Theses

Background: In recent years, the renewed global interest in both hallucinogens’ and cannabis’ therapeutic properties has resulted in shifting attitudes and legislative policies worldwide. The aim of this systematic review is to explore the existing literature on medical professionals’ and students’ attitudes and knowledge regarding medicinal cannabis (MC) to assess any relevant and significant trends which may forecast analogous trends in the nascent clinical acceptance of hallucinogens.

Methods: Using Google Scholar and PubMed, a literature search was performed to identify studies pertaining to healthcare professionals’ and medical students’ knowledge and attitudes regarding MC. This systematic search yielded 43 studies published …

Host Restriction Factors In The Replication Of Tombusviruses: From Rna Helicases To Nucleocytoplasmic Shuttling, Cheng-Yu Wu

Theses and Dissertations--Plant Pathology

Positive-stranded (+)RNA viruses replicate inside cells and depend on many cellular factors to complete their infection cycle. In the meanwhile, (+)RNA viruses face the host innate immunity, such as cell-intrinsic restriction factors that could block virus replication.

Firstly, I have established that the plant DDX17-like RH30 DEAD-box helicase conducts strong inhibitory function on tombusvirus replication when expressed in plants and yeast surrogate host. This study demonstrates that RH30 blocks the assembly of viral replicase complex, the activation of RNA-dependent RNA polymerase function of p92pol and viral RNA template recruitment.

In addition, the features rendering the abundant plant DEAD-box helicases either …