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Healing Wounds Through Nutrition, Deanna Garza

Master's Projects and Capstones

Abstract

The role of nutrition in wound care is often overlooked. The main reasons why wounds fail to heal are malnutrition, infection, impaired organ function due to co-existing diseases such as diabetes, hypertension, renal disease, and peripheral vascular disease to name a few. These factors have contributed to poor patient outcomes and patient satisfaction, as well as an increase in hospital length of stay. To promote wound healing, fuel from macro and micronutrients are necessary to deliver oxygen and energy for cell regeneration. However, nurses must possess knowledge and understanding of these requirements and the effects of nutrition on wound …

Cassava Farming Practices And Their Agricultural And Environmental Impacts: A Systematic Map Protocol, Gorm E. Shackelford, Neal R. Haddaway, Hope O. Usieta, Pieter Pypers, Silviu O. Petrovan, William J. Sutherland

All Peer-Reviewed Publications

Background: Cassava (Manihot esculenta) is a staple crop that is important for food security in the tropics. However, cassava farming can have severe environmental impacts, such as habitat destruction and soil degradation, if it is not carefully managed. Therefore, a wide range of agricultural and environmental outcomes should be considered when cassava farming practices are recommended as "good agricultural practices". We propose a systematic map of research on cassava farming practices and their impacts on yield, quality, profitability, soil, water, wildlife, pathogens, pests, weeds, and other agricultural and environmental outcomes. This map will improve our knowledge of the multifunctionality of …

G-A Gameday Newsletters- Pre Game, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Computational Explorations Of Information And Mechanism Design In Markets, Zhuoshu Li

McKelvey School of Engineering Graduate Student Theses & Dissertations

Markets or platforms assemble multiple selfishly-motivated and strategic agents. The outcomes of such agent interactions depend heavily on the rules, regulations, and norms of the platform, as well as the information available to agents. This thesis investigates the design and analysis of mechanisms and information structures through the ``computational lens'' in both static and dynamic settings. It both addresses the outcome of single platforms and fills a gap in the study of the dynamics of multiple platform interactions.

In static market settings, we are particularly interested in the role of information, because mechanisms are harder to change than the information …

Learning About Large Scale Image Search: Lessons From Global Scale Hotel Recognition To Fight Sex Trafficking, Abby Stylianou

McKelvey School of Engineering Graduate Student Theses & Dissertations

Hotel recognition is a sub-domain of scene recognition that involves determining what hotel is seen in a photograph taken in a hotel. The hotel recognition task is a challenging computer vision task due to the properties of hotel rooms, including low visual similarity between rooms in the same hotel and high visual similarity between rooms in different hotels, particularly those from the same chain. Building accurate approaches for hotel recognition is important to investigations of human trafficking. Images of human trafficking victims are often shared by traffickers among criminal networks and posted in online advertisements. These images are often taken …

Biosensing By “Growing” Antennas And Error-Correcting Codes, Mingquan Yuan

McKelvey School of Engineering Graduate Student Theses & Dissertations

Food-borne disease outbreaks not only cause numerous fatalities every year but also contribute to significant economic losses. While end-to-end supply chain monitoring can be one of the keys to preventing these outbreaks, screening every food product in the supply chain is not feasible considering the sheer volume and prohibitive test costs. Fortunately, two converging economic trends promise to make this end-to-end supply chain monitoring possible. The first trend is that passive radio-frequency identification (RFID) tags and quick response (QR) codes are now widely accepted for food packaging. The second trend is that smartphones are now equipped with the capability to …

Effects Of Secondary Stall And Unsteady Free-Stream On Blade Drag And Pitching Moments, Michael Malick

McKelvey School of Engineering Graduate Student Theses & Dissertations

Dynamic stall is a complex aerodynamic phenomenon occurring in helicopter rotors, limiting the flight envelope and causing control linkage damage and instabilities. The Peters-Modarres semi-empirical dynamic stall model is extended to simulate pitching moment and drag in unsteady freestream and yawed flow, including the effects of secondary stall. The aerodynamics are implemented as a state-space model, suitable for time-marching or aeroelastic analyses. With small modifications to the original stall model, secondary stall effects and unsteady freestream can be simulated without adding additional states. An optimization routine determines sets of parameters that minimize the error between the modeled solution and experimental …

Basis Vector Model Method For Proton Stopping Power Estimation Using Dual-Energy Computed Tomography, Shuangyue Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Accurate estimation of the proton stopping power ratio (SPR) is important for treatment planning and dose prediction for proton beam therapy. The state-of-the-art clinical practice for estimating patient-specific SPR distributions is the stoichiometric calibration method using single-energy computed tomography (SECT) images, which in principle may introduce large intrinsic uncertainties into estimation results. One major factor that limits the performance of SECT-based methods is the Hounsfield unit (HU) degeneracy in the presence of tissue composition variations. Dual-energy computed tomography (DECT) has shown the potential of reducing uncertainties in proton SPR prediction via scanning the patient with two different source energy spectra. …

Investigating Cyanobacteria Metabolism And Channeling-Based Regulations Via Isotopic Nonstationary Labeling And Metabolomic Analyses, Mary Helen Abernathy

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cyanobacteria have the potential to be low-cost and sustainable cell factories for bio-products; however, many challenges face cyanobacteria as biorefineries. This dissertation seeks to advance non-model photosynthetic organisms for biotechnology applications by characterizing central carbon metabolism and its regulations. Cyanobacteria phenotypes for bio-production are examined and their intracellular metabolism is quantified. Using isotopic labeling experiments, phenotypic relationships between biomass composition, central carbon fluxes, and metabolite pool sizes are investigated. Metabolic analyses of cyanobacteria led to new investigations of flux regulation mechanisms via protein spatial organizations or metabolite channeling. Metabolite channeling is further explored as a hypothesis to explain enigmatic labeling …

Graphene Oxides In Water: Characterization, Reactivity, And Application, Siyuan An

McKelvey School of Engineering Graduate Student Theses & Dissertations

Recently discovered, graphene and graphene oxide materials have drawn considerable research attention due to outstanding and novel properties, which underpin wide material potential for a number of advanced applications including supercapacitors, solar cells, sensors, catalysts, semiconductors, sorbents, and membranes, among others. Graphene oxides (GO), which are considered as a family of oxidized graphene materials (derivatives), is a key precursor to the synthesis of free-standing graphene via oxidation-exfoliation-reduction pathways. GO properties depend on the synthesis routes/conditions (i.e. derivatization), including partially maintaining graphene (i.e. sp2) properties. Further, oxygen-containing functionalities (epoxy, hydroxyl, carbonyl, and carboxyl groups) render GO hydrophilic – and correspondingly stability …

Mechanisms Of Calcium Phosphate Mineralization On Biological Interfaces And Their Engineering Applications, Doyoon Kim

McKelvey School of Engineering Graduate Student Theses & Dissertations

All living organisms utilize phosphorus (P) as an essential component of their cell membranes, DNA and RNA, and adenosine triphosphate. Bones, in addition to bearing loads, play an important role in balancing P levels in our bodies. In bones, a network of collagen templates and calcium phosphate (CaP) nanocrystals builds hierarchical levels, from nano- to macroscale. Within this architecture, the thermodynamic properties of CaP minerals are influential. Despite the importance of nucleation, growth, and crystallization in collagen structures for tissue development, little kinetic study of these processes has been conducted due to the limited in situ techniques for monitoring these …

Decoding Complexity In Metabolic Networks Using Integrated Mechanistic And Machine Learning Approaches, Tolutola Timothy Oyetunde

McKelvey School of Engineering Graduate Student Theses & Dissertations

How can we get living cells to do what we want? What do they actually ‘want’? What ‘rules’ do they observe? How can we better understand and manipulate them? Answers to fundamental research questions like these are critical to overcoming bottlenecks in metabolic engineering and optimizing heterologous pathways for synthetic biology applications. Unfortunately, biological systems are too complex to be completely described by physicochemical modeling alone.

In this research, I developed and applied integrated mechanistic and data-driven frameworks to help uncover the mysteries of cellular regulation and control. These tools provide a computational framework for seeking answers to pertinent biological …

Towards Engineering Advanced Nanomaterials: Elucidating Fundamental Particle Behavior In Water And Critical Sorption Dynamics, Changwoo Kim

McKelvey School of Engineering Graduate Student Theses & Dissertations

As advanced nanomaterials, inorganic-organic nano composites have received great interest as potential platform (nano) structures for sensor, catalyst, sorbent, and environmental applications. Here, my Ph.D. research has focused on the design, synthesis, and characterization of advanced water-stable engineered metal-oxide nanoparticles functionalized by organic frames for environmental applications. For the environmental applications, I have evaluated particleoptimized sorption processes for the remediation and separation of arsenic, chromium, and uranium under environmentally relevant conditions. More specifically, I have explored the critical role of organic coating on sorption mechanisms and performances using engineered iron oxide -based, manganese oxide -based, and manganese ferrite -based (core) …

Multifunctional Nanocomposites Based On Bacterial Cellulose, Qisheng Jiang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cellulose is biodegradable, renewable, and abundant in nature thus cellulose (or paper)-based products can be inexpensively produced and recycled. Among cellulosic materials, bacterial nanocellulose (BNC) draws a special research attention due to the inherent three-dimensional nanofibrous structure, excellent mechanical flexibility, high purity and well-defined surface chemistry, and cost-efficient, scalable and environment-friendly synthesis. BNC can be biosynthesized by Gluconacetobacter xylinus, which is the most characterized BNC producer among various microorganisms. BNC is composed of highly pure cellulose nanofibrils, produced from well-defined dextrose through biochemical steps and subsequent self-assembling of the secreted cellulose fibrils which has the dimension ranges from 25 to …

Information-Based Analysis And Control Of Recurrent Linear Networks And Recurrent Networks With Sigmoidal Nonlinearities, Deslin Menolascino

McKelvey School of Engineering Graduate Student Theses & Dissertations

Linear dynamical models have served as an analytically tractable approximation for a variety of natural and engineered systems. Recently, such models have been used to describe high-level diffusive interactions in the activation of complex networks, including those in the brain. In this regard, classical tools from control theory, including controllability analysis, have been used to assay the extent to which such networks might respond to their afferent inputs. However, for natural systems such as brain networks, it is not clear whether advantageous control properties necessarily correspond to useful functionality. That is, are systems that are highly controllable (according to certain …

Multifunctional Nanocomposites Based On Bacterial Cellulose, Qisheng Jiang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Cellulose is biodegradable, renewable, and abundant in nature thus cellulose (or paper)-based products can be inexpensively produced and recycled. Among cellulosic materials, bacterial nanocellulose (BNC) draws a special research attention due to the inherent three-dimensional nanofibrous structure, excellent mechanical flexibility, high purity and well-defined surface chemistry, and cost-efficient, scalable and environment-friendly synthesis. BNC can be biosynthesized by Gluconacetobacter xylinus, which is the most characterized BNC producer among various microorganisms. BNC is composed of highly pure cellulose nanofibrils, produced from well-defined dextrose through biochemical steps and subsequent self-assembling of the secreted cellulose fibrils which has the dimension ranges from 25 to …

Effects Of Secondary Stall And Unsteady Free-Stream On Blade Drag And Pitching Moments, Michael Malick

McKelvey School of Engineering Graduate Student Theses & Dissertations

Dynamic stall is a complex aerodynamic phenomenon occurring in helicopter rotors, limiting the flight envelope and causing control linkage damage and instabilities. The Peters-Modarres semi-empirical dynamic stall model is extended to simulate pitching moment and drag in unsteady freestream and yawed flow, including the effects of secondary stall. The aerodynamics are implemented as a state-space model, suitable for time-marching or aeroelastic analyses. With small modifications to the original stall model, secondary stall effects and unsteady freestream can be simulated without adding additional states. An optimization routine determines sets of parameters that minimize the error between the modeled solution and experimental …

Kcnq1/Kcne1 Interaction In The Cardiac Iks Channel And Its Physiological Consequences, Jiajing Xu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Dynamic conformational changes of ion channel proteins during activation gating determine their function as carriers of current. The relationship between these molecular movements and channel function over the physiological timescale of the action potential (AP) has not been fully established due to limitations of existing techniques. We constructed a library of possible cardiac IKs protein conformations and applied a combination of protein segmentation and energy linearization to study this relationship computationally. Simulations reproduced the effects of the beta-subunit (KCNE1) on the alpha-subunit (KCNQ1) dynamics and function, observed in experiments. Mechanistically, KCNE1 increased the probability of “visiting” conducting pore conformations on …

Molecular Basis Of Class Ib Drug Interactions With The Nav Channel Macromolecular Complex: A Route To Personalized Medicine For Cardiac Arrhythmia, Wandi Zhu

McKelvey School of Engineering Graduate Student Theses & Dissertations

The heart rhythm is precisely controlled by the electrical impulse that propagate in the cardiac tissue. In single cardiomyocytes, the electrical activity generated by action potentials (AP). Cardiac NaV channels (NaV1.5) carry a large influx of Na+ that mediates the initiation and propagation of the AP in both atria and ventricles. Disruption of NaV1.5 function by genetic variants or external factors can result in deadly arrhythmias, such as long QT syndrome and Brugada syndrome. Thus, NaV channels are import therapeutic targets. The class I antiarrhythmics are the modulators of the NaV channels. Although they have been used clinically for over …

The Role Of Fibrillin-1 In Eye Development And Disease, Wendell Brooks Jones

Arts & Sciences Graduate Student Theses and Dissertations

The ciliary zonule of the human eye consists of a circumferential array of fibers that connect the ocular lens to the nonpigmented ciliary epithelium (NPCE) located at the inner wall of the eye. Zonular fibers consist of bundles of beaded filaments called microfibrils. Microfibrils are major structural elements of the extracellular matrix and are present in pure form in the ciliary zonule. Microfibrils are composed principally of fibrillin-1 (FBN-1); a large extracellular matrix glycoprotein. In humans, mutations in FBN1 underlie Marfan syndrome; a pleiotropic connective tissue disorder that profoundly affects the eye. Ocular manifestations include ectopia lentis (dislocated lenses), cataracts, …

The Splice Is Not Right: Splice-Site-Creating Mutations In Cancer Genomes, Reyka Glencora Jayasinghe

Arts & Sciences Graduate Student Theses and Dissertations

Accurate interpretation of cancer mutations in individual tumors is a prerequisite for precision medicine. Large-scale sequencing studies, such as The Cancer Genome Atlas (TCGA) project, have worked to address the functional consequences of genomic mutations, with the larger goal of determining the underlying mechanisms of cancer initiation and progression. Many studies have focused on characterizing non-synonymous somatic mutations that alter amino acid sequence, as well as splice disrupting mutations at splice donors and acceptors. Current annotation methods typically classify mutations as disruptors of splicing if they fall on the consensus intronic dinucleotide splice donor, GT, the splice acceptor, AG. Splice …

Sequence Analysis Methods For The Design Of Cancer Vaccines That Target Tumor-Specific Mutant Antigens (Neoantigens), Jasreet Hundal

Arts & Sciences Graduate Student Theses and Dissertations

The human adaptive immune system is programmed to distinguish between self and non-self proteins and if trained to recognize markers unique to a cancer, it may be possible to stimulate the selective destruction of cancer cells. Therapeutic cancer vaccines aim to boost the immune system by selectively increasing the population of T cells specifically targeted to the tumor-unique antigens, thereby initiating cancer cell death.. In the past, this approach has primarily focused on targeted selection of ‘shared’ tumor antigens, found across many patients. The advent of massively parallel sequencing and specialized analytical approaches has enabled more efficient characterization of tumor-specific …

Intersecting Variables Of Second And Foreign Language Reading: Self-Assessment And Comprehension With Adolescents And Adults Across Languages, Haley Dolosic

Arts & Sciences Graduate Student Theses and Dissertations

Today, more individuals are seeking to learn a second language (L2) or foreign language (FL) than ever before. These individuals are language learners who intend to use their growing L2 knowledge to traverse linguistic and national boundaries in order to achieve their personal and professional goals (Callahan & Gándara, 2014). To realize these goals in the digital era, L2 learners must be more prepared than ever to use their knowledge with written media, making L2 reading a central skill to successful use of their L2 knowledge. Yet, when language learners attempt to use their L2 skills in their daily lives, …

Photophysical Characterization And Wavelength Tuning Of Natural And Synthetic Oxobacteriochlorins And Biohybrids, Don Hood

Arts & Sciences Graduate Student Theses and Dissertations

ABSTRACT OF THE DISSERTATIONPhotophysical Characterization and Wavelength Tuning of Natural and Synthetic Oxobacteriochlorins and BiohybridsByDonald L. HoodDoctor of Philosophy in ChemistryWashington University in St. Louis, 2018Dr. Dewey Holten, ChairpersonHerein is discussed the theoretical and practical unpinnings of photophysical behaviors and kinetic constants for tetrapyrrole macrocycles, to wit, porphyrins, chlorins, and bacteriochlorins. Understanding the characteristic photophysical response of tetrapyrroles to changes in environment or substituents is important to designing synthetic chromophores with tunable absorption wavelengths and for preparing useful biohybrids of natural photosynthetic light antennas combined with unnatural chromophores attached to the light antenna oligomers. Synthetic oxobacteriochlorins provide simpler synthetic pathway …

Tunable Electronic And Optical Properties Of Low-Dimensional Materials, Shiyuan Gao

Arts & Sciences Graduate Student Theses and Dissertations

Two-dimensional (2D) materials with single or a few atomic layers, such as graphene, hexagonal boron nitride (h-BN) and transition metal dichalcogenides (TMDCs), and the heterostructures or one-dimensional (1D) nanostructures they form, have attracted much attention recently as unique platforms for studying many condensed-matter phenomena and holds great potentials for nanoelectronics and optoelectronic applications. Apart from their unique intrinsic properties which has been intensively studied for over a decade by now, they also allow external control of many degrees of freedom, such as electrical gating, doping and layer stacking. In this thesis, I present a theoretical study of the electronic and …

Mechanistic Characterization Of Resistome And Microbiome Dynamics Across Diverse Microbial Habitats, Andrew John Gasparrini

Arts & Sciences Graduate Student Theses and Dissertations

Increasing antibiotic resistance in pathogens is a serious public health challenge, with over two million antibiotic resistant infections in the United States leading to at least 23,000 deaths and an estimated $55 billion in excess healthcare and societal costs. Antibiotic resistance has risen steadily in both pathogenic and benign bacteria since antibiotics’ introduction to agriculture and medicine 70 years ago. A dramatic reduction in the number of antibiotics approved for human use has accompanied this rise in antibiotic resistance, leading to the alarming prospect of a post-antibiotic era. Understanding the evolutionary origins, genetic contexts, and molecular mechanisms of antibiotic resistance …

Grammar And Variation: Understanding How Cis-Regulatory Information Is Encoded In Mammalian Genomes, Dana Michele King

Arts & Sciences Graduate Student Theses and Dissertations

Understanding how genotype leads to phenotype is key to understand both the development and dysfunction of complex organisms. In the context of regulating the gene expression patterns that contribute to cell identity and function, the goal of my thesis research is to how changes in genome sequence may impact impact gene expression by determining how sequence features contribute to regulatory potential. To accomplish this goal, I first leveraged the key regulatory role of pluripotency transcription factors (TFs) in mouse embryonic stem cells (mESCs) and tested synthetically generated and genomic identified combinations of binding site for four TFs, OCT4, SOX2, KLF4, …

A Tail Of Two Pancancer Projects: Somatic Variant Identification And Driver Gene Discovery Using Tcga, Matthew Hawkins Bailey

Arts & Sciences Graduate Student Theses and Dissertations

The implementation of next-generation genomic sequencing has exploded over the past dozen years. Large consortia, such as The Cancer Genome Atlas (TCGA); the International Cancer Genetics Consortium (ICGC); and the Pediatric Cancer Genome Projects (PCGP), made great strides in democratizing big data for the scientific community. These data sets provide a rich resource to build tools for somatic variant discovery and exploratory analysis. Public repositories hold the answer to many novel biological and clinical revelations i.e., the discovery of complex indels, splice creating mutations, alternative super enhancer binding sites, machine learning models to predict mutation impact, and cancer subtype classification …

Radiolabeled Nanohydroxyapatite As A Platform For The Development Of New Pet Imaging Agents, Stacy Lee Queern

Arts & Sciences Graduate Student Theses and Dissertations

Positron emission tomography (PET) imaging utilizes drugs labeled with positron emitters to target and evaluate different biological processes occurring in the body. Tailoring medicine to the individual allows for higher quality of care with better diagnosis and treatment and is a key purpose for advancing research into developing new platforms for PET imaging agents. A PET nuclide of high interest for the development of these agents is 89Zr. This can be attributed to the long half-life of 3.27 days and low positron energy of 89Zr.In this work, we developed a production method for 89Zr using Y sputtered coins that is …

Unsettling Geographies: Primitivist Utopias In Queer American Literature From Walt Whitman To Willa Cather, Benjamin Meiners

Arts & Sciences Graduate Student Theses and Dissertations

In “Unsettling Geographies: Primitivist Utopias in Queer American Literature from Walt Whitman to Willa Cather,” I argue that the colonial discourse of primitivism played a central role in the queer literary imaginaries of both canonical and non-canonical U.S. authors. Building on the work of historians of sexuality who trace the complex development of the twentieth-century homo-/hetero- binary, I show how literary works produced in this historical moment—roughly 1860 to 1925—explored and in some instances even advocated alternative queer modes of citizenship and erotic imagination and practice. Focusing on the works of Walt Whitman, Emily Dickinson, Charles Warren Stoddard, and Willa …