Digital Commons Network^™

Small Town Capital In Community, Christin Hardy

Theses and Dissertations

Rural towns often do not see community developments geared towards creating public spaces for multi-cultural experiences, the arts and recreation. Instead small towns are more exposed to commercial properties coming in and out the area. Introducing public spaces that offer various community activities and events will benefit people’s human and social capital. Human capital meaning skills and knowledge. Social capital meaning advantages and skills that come from interpersonal engagements (Anderson, 2004). Community centers designed for the unique needs of small towns can house programming to introduce new and rewarding opportunities for community engagement and personal development. Existing buildings within the …

A Behavior-Driven Recommendation System For Stack Overflow Posts, Chase D. Greco

Theses and Dissertations

Developers are often tasked with maintaining complex systems. Regardless of prior experience, there will inevitably be times in which they must interact with parts of the system with which they are unfamiliar. In such cases, recommendation systems may serve as a valuable tool to assist the developer in implementing a solution. Many recommendation systems in software engineering utilize the Stack Overflow knowledge-base as the basis of forming their recommendations. Traditionally, these systems have relied on the developer to explicitly invoke them, typically in the form of specifying a query. However, there may be cases in which the developer is in …

Nam June Paik As A Pioneer Of Interactive Art, Byeongwon Ha

Theses and Dissertations

Nam June Paik (1932-2006) is well known as the father of video art. However, this study demonstrates the importance of his earlier interactive art (1961-63), which historically has been overshadowed by his video art. At the climax of his career in interactive art, Paik introduced his two-way art to the public at his first solo exhibition in Wuppertal, West Germany, in 1963. Interactive art itself has been a peripheral area in the history of art, and it has plural pioneers across disciplinary boundaries. Among the several origins of interactive art, Nam June Paik utilized music as a fundamental approach to …

Cellular Inhibitor Of Apoptosis Protein2 – A Critical Regulator Of Neuroinflammation, Debolina Dipankar Biswas

Theses and Dissertations

Inhibitors of apoptosis (IAPs) modulate cell death and play critical role in signal transduction that promotes inflammation. Recently, Smac mimetics, which are IAP antagonists, have attracted attention as novel cancer therapeutics. Cellular Inhibitor of Apoptosis 2 (cIAP2), a member of IAP family, positively affects both NF-κB and MAPK activation in response to many inflammatory stimuli. We observed that the lack of cIAP2 ablates LPS-induced neuroinflammation. Also, cIAP2^-/- macrophages demonstrated diminished antigen presentation potential that could contribute to ablated immunity. In addition to these functions, we have previously reported that cIAP2 also regulates the activation of Interferon Regulatory Factor 1 …

The Mall: A World-Building Speculation On The Future Of Privacy, Hazem Asif

Theses and Dissertations

This thesis is a science fiction exploration of a future dystopian world where privacy becomes a dominant currency that is distributed according to social class and ranking mechanisms. It utilizes speculative world-building to study the unanticipated implications of technology on personal privacy, surveillance and social inequality on future societies. The project introduces The Mall, as a highly efficient and hyper-connected world, but also exposes its downfall as a society with heightened cultural and socio-political disparities. Inspired by past civilizations, the development of the modern nation-state as well as contemporary society, the design adapts, appropriates and reformulates existing cultures into new …

Influence Of Cultural Strengths On The Relationships Among Acculturative Stress, Racism, And Mental And Physical Health In Latino Immigrants, Annahir N. Cariello

Theses and Dissertations

The Latino immigrant population in the United States has grown rapidly, now standing at over 56 million people. Due to this increase in Latino immigrants, investigation of their mental and physical health is crucial. Few studies have investigated conjointly both physical and mental health in Latino immigrant adults. Daily discrimination and acculturative stress have been found to affect the mental and physical health of Latino immigrants. Cultural strengths including social support, religiosity, and enculturation have been linked to Latino immigrant health. In the minority stress model, cultural strengths have been theorized to moderate relationships between discrimination and health. The purpose …

Geodesic Structure In Schwarzschild Geometry With Extensions In Higher Dimensional Spacetimes, Ian M. Newsome

Theses and Dissertations

From Birkoff's theorem, the geometry in four spacetime dimensions outside a spherically symmetric and static, gravitating source must be given by the Schwarzschild metric. This metric therefore satisfies the Einstein vacuum equations. If the mass which gives rise to the Schwarzschild spacetime geometry is concentrated within a radius of r=2M, a black hole will form. Non-accelerating particles (freely falling) traveling through this geometry will do so along parametrized curves called geodesics, which are curved space generalizations of straight paths. These geodesics can be found by solving the geodesic equation. In this thesis, the geodesic structure in the Schwarzschild geometry …

Abuse Liability Of An Electronic Cigarette In Traditional Cigarette Smokers, Sarah F. Maloney

Theses and Dissertations

Electronic cigarettes have grown in popularity across the U.S. and concerns have been raised about their abuse liability. The purpose of the current study was to evaluate and compare the abuse liability of an electronic cigarette with and without nicotine to a nicotine inhaler (the Nicotrol inhaler) and participants’ own brand of cigarettes. A total of 24 smokers attended four sessions in which the abuse liability of each product was examined using the Multiple-Choice Procedure (MCP), nicotine delivery, nicotine abstinence symptom suppression, and subjective reinforcing effects. Results revealed that the nicotine containing and non-nicotine containing electronic cigarette had a higher …

Social Soul, Norah Alshammari

Theses and Dissertations

Twitter has over 313 million users, with 500 million tweets produced each day.

Society’s growing dependence on the internet for self-expression shows no

sign of abating. However, recent research warns that social media perpetuates

loneliness, caused by reduced face-to-face interaction. My thesis analyzes and

demonstrates the important role facial expressions play in a conversation’s

progress, impacting how people process and relate to what is being said. My

work critically assesses communication problems associated with Twitter. By

isolating and documenting expressive facial reactions to a curated selection

of tweets, the exhibition creates a commentary on our contemporary digital

existence, specifically articulating …

"Let The Castillo Be His Monument!": Imperialism, Nationalism, And Indian Commemoration At The Castillo De San Marcos National Monument In St. Augustine, Florida, Claire M. Barnewolt

Theses and Dissertations

The Castillo de San Marcos is the oldest stone fortification on the North American mainland, a unique site that integrates Florida’s Spanish colonial past with American Indian narratives. A complete history of this fortification from its origins to its management under the National Park Service has not yet been written. During the Spanish colonial era, the Indian mission system complemented the defensive work of the fort until imperial skirmishes led to the demise of the Florida Indian. During the nineteenth century, Indian prisoners put a new American Empire on display while the fort transformed into a tourist destination. The Castillo …

Lps-Induced Inos Mrna And The Pro-Apoptotic Signaling Pathway In Leukocytes Of Fit And Unfit Males, Tiffany M. Zuniga

Theses and Dissertations

Overexpression of the enzyme iNOS induces apoptotic cellular death by increasing indices of pro-inflammation and oxidative stress. Aerobic physical activity has been known to have anti- inflammatory benefits and reduce oxidative stress. Purpose: Therefore, this study aimed to examine the impact of aerobic fitness on LPS-induced iNOS mRNA expression and the relationship of this expression with indices of oxidative stress, pro-inflammation and apoptosis in isolated leukocytes. Methods: Whole blood samples from aerobically fit and unfit males were stimulated with and without LPS. Thereafter, iNOS mRNA expression and MDA, TNF-α and p53 concentrations were analyzed. Results: iNOS mRNA expression levels following …

Redox Reactions At Oil-Water Interface By Particle Collision Electroanalysis, Dilip K. Paul

Theses and Dissertations

Particle Collision Electrochemistry (PCE) has gained considerable attention in heterogeneous catalysis, petroleum chemistry and pharmaceutical fields. The PCE refers to a phenomenon in which a particle strikes on an inert electrode surface as a consequence of its Brownian motion and produces a spike of current for the direct oxidation/reduction of the individual particle. This method allows us characterization of individual particles and in-situ study of electrochemical reactions coupled to the particle.

Herein, emulsion droplets were studied by PCE where toluene droplets contained hydrophobic tetrachloro-1,4-benzoquinone (Q). This was investigated as a model system to study the molecular effects that arise due …

Understanding Knowledge Sharing Motivation In The Public Sector: Application Of Self-Determination And Person-Environment Fit Theories, Jaeyong Lee

Theses and Dissertations

Knowledge has been recognized as an important resource that should be carefully managed in order to enhance organizational competitiveness. Therefore, it is important to manage knowledge resources that have been learned and stored in organizations. Several scholars in the public administration literature have examined whether public service motivation (PSM) can help employees share their knowledge in ways that contribute to the effective functioning of public organizations. However, the mechanisms by which PSM influences individuals’ propensity to share knowledge have not been clarified by past research.

Against this background, at first, this study contributes to understanding the relationship between PSM and …

Parent-Implemented Communication Intervention For Preschool-Aged Children With Autism, Heather M. Coleman

Theses and Dissertations

Exploring the interventions that promote expressive, verbal language for preschool-aged children with autism is essential. When a child is lacking the ability to communicate, parents express that they would like their child to speak. B.F. Skinner (1957) proposed that the mand repertoire (communicative requests) should be an initial focus of language training. Mand training has been shown to be effective for teaching children with autism to communicate. However, many studies exploring mand training utilize highly trained instructors for intervention implementation. Early childhood best practices recommend the use of family-centered interventions and teaching within the natural environment. This study followed these …

Detection Of Genetic Abnormalities Using High Speed Atomic Force Microscopy, Anita J. Olsen

Theses and Dissertations

Genetic mutations in the regulatory genes responsible for cell proliferation, differentiation, and death play a significant role in cancer. Molecular diagnostic and sequencing techniques used to detect these abnormalities have limitations that need to be overcome. These issues can be addressed with the use of a novel High-Speed Atomic Force Microscope (HS-AFM) taking physical measurement of molecules labeled with a programmable nanoparticle (Cas9). This technique was used to demonstrate proof-of-concept using genetic mutations found in breast cancer and follicular lymphoma.

Current quantification methods for copy number variation (gene duplication) and gene expression analysis are based on amplification and fluorescence-based techniques …

Chronic Clozapine Treatment Impairs Functional Activation Of Metabotropic Glutamate Receptor 2 Via An Hdac2-Depedent Mechanism, Travis M. Cuddy

Theses and Dissertations

Schizophrenia is a chronic mental disorder affecting millions worldwide. It has no known cure. Current pharmaceutical treatments have shown efficacy in only one of the three symptom clusters of schizophrenia, providing little or no benefit in the other two. Furthermore, the current standard-of-care drugs, known as atypical antipsychotics, carry risks of severe side effects affecting multiple body systems. Most patients opt to discontinue drug therapy within two years of initiation due to lack of efficacy and/or preponderance of adverse effects. Previous findings have shown that chronic usage of atypical antipsychotics causes a 5-HT_2A-dependent upregulation of histone deacetylase 2 …

Effects Of The Na-Cl Co-Transporter (Ncc) In Western Diet Induced Metabolic And Cardiac Dysfunction, Zachary S. Cutter

Theses and Dissertations

Interleukin-18 (IL-18) is a pro-inflammatory cytokine known to be involved in maintaining metabolic homeostasis; however, also capable of inducing cardiac dysfunction. Additionally, IL-18, has been shown to bind to a novel receptor, the Na-Cl Co-transporter (NCC). We hypothesized that NCC mediates IL-18 metabolic and cardiac signaling in mice. Using male C57BL/6J mice, we compared the metabolic and cardiac function changes after at least 8 weeks of high-saturated fat high sugar diet (Western Diet) in NCC knockout (NCCKO), IL-18 knockout (IL-18KO), and wild-type mice. We show that NCCKO mice have significantly increased body weight gain from baseline, no difference in fasting …

Migratory Patterns And Population Genetic Structure In A Declining Wetland-Dependent Songbird, Matthew G. Desaix

Theses and Dissertations

Understanding migratory connectivity is essential for assessing the drivers behind population dynamics and for implementing effective management in migratory species. Genetic markers provide a means to describe migratory connectivity, as well as incorporate population genetic analyses, however genetic markers can be uninformative for species with weak genetic structure. In this study, we evaluate range-wide population genetic structure and migratory connectivity in the prothonotary warbler, Protonotaria citrea, a wetland-dependent neotropical migratory songbird, using high-resolution genetic markers. We reveal regional genetic structure between sampling sites in the Mississippi River Valley and the Atlantic Seaboard with overall weak genetic differentiation among populations …

She Inches Glass To Break: Conversations Between Friends, Liang Xia Luscombe

Theses and Dissertations

She inches glass to break: conversations between friends is a project that aims to manifest, through research and practice, my own feminist language within the videos I have produced in my final year of my Masters of Fine Arts. My feminist language is Australian and intersectional, invested in combating sexism, racism and in deepening language and representation around sexuality in relation to Asian women. This project discusses my video She inches glass to break (2018) in length, which created intersectional feminist dialogue in response to feminist filmmaker Ulrike Ottinger’s film Ticket of No Return (1979) and Breakfast at Tiffany’s (1961). …

Ultrasound—Re:Viewing Bodies, Minjee Jeon

Theses and Dissertations

A medical evaluation of physical impairment imposes the additional burden of “labeling” the patient with the condition. The binary nature of the normal versus abnormal label emphasizes difference and can lead to trauma. Understanding differences, however, can lead to the generation of new forms and thus, more sensitive differentiation and representation. Tension is created by exploring different bodily forms—a dialectic between form and essence. I am designing a space that visualizes and illuminates difference as a source of trauma and amplifying the tension by comparing figures that represent varying degrees of normalcy. This forms a critique of idealized form and …

Investigating Smoke Exposure And Chronic Obstructive Pulmonary Disease (Copd) With A Calibrated Agent Based Model (Abm) Of In Vitro Fibroblast Wound Healing., James A. Ratti

Theses and Dissertations

COPD is characterized by tissue inflammation and impaired remodeling that suggests fibroblast maintenance of structural homeostasis is dysregulated. Thus, we performed in vitro wound healing experiments on normal and diseased human lung fibroblasts and developed an ABM of fibroblasts closing a scratched monolayer using NetLogo to evaluate differences due to COPD or cigarette smoke condensate exposure. This ABM consists of a rule-set governing the healing response, accounting for cell migration, proliferation, death, activation and senescence rates; along with the effects of heterogeneous activation, phenotypic changes, serum deprivation and exposure to cigarette smoke condensate or bFGF. Simulations were performed to calibrate …

Consuming Digital Debris In The Plasticene, Stephen R. Parks

Theses and Dissertations

Claims of customization and control by socio-technical industries are altering the role of consumer and producer. These narratives are often misleading attempts to engage consumers with new forms of technology. By addressing capitalist intent, material, and the reproduction limits of 3-D printed objects’, I observe the aspirational promise of becoming a producer of my own belongings through new networks of production. I am interested in gaining a better understanding of the data consumed that perpetuates hyper-consumptive tendencies for new technological apparatuses. My role as a designer focuses on the resolution of not only the surface of the object through 3-D …

Quotations Like The Sharpest Claws, Johanna Robinson

Theses and Dissertations

Quotations like the Sharpest Claws describes a multimedia installation composed of paintings and sound that explores the theory of cognitive dissonance, a controversial psychological model that attempts to explain how we deal with inconsistency in incompatible beliefs. Imagination is given primacy as a source for truth-seeking and world-building. The uncanny and surreal are used as entry points into this topic.

The title is derived from a description of Eileen Myles’ poetry I once read in an anonymous review. Their writing was described as beyond poetry in a way that it could only be described as such when surrounded by “quotations …

Nitrogen Rich Porous Organic Frameworks: Proton Conduction Behavior Of 3d Benzimidazole And Azo-Linked Polymers, Michael J. Anhorn

Theses and Dissertations

Nitrogen-rich porous organic frameworks show great promise for use as acid-doped proton conducting membranes, due to their high porosity, excellent chemical and thermal stability, ease of synthesis, and high nitrogen content. Aided by very high surface area and pore volume, the material has the ability to adsorb high amounts of H₃PO₄ into its network, which creates a proton rich environment, capable of facile proton conduction. The morphology and chemical environment, doping behavior, and proton conduction of these materials were investigated. With such high acid-doping, ex-situ studies revealed that under anhydrous conditions, PA@BILP-16 (AC) produced a proton conductivity …

Work/Death, Of Each In Their Own, Micah H. Weber

Theses and Dissertations

Writings in support of my visual thesis, including some background, and bibliographic information: Oregon/Death/Animation/Vocation and the artist as an agent of potential.

Advances In Dual-Energy Computed Tomography Imaging Of Radiological Properties, Dong Han

Theses and Dissertations

Dual-energy computed tomography (DECT) has shown great potential in the reduction of uncertainties of proton ranges and low energy photon cross section estimation used in radiation therapy planning. The work presented herein investigated three contributions for advancing DECT applications. 1) A linear and separable two-parameter DECT, the basis vector model (BVM) was used to estimate proton stopping power. Compared to other nonlinear two-parameter models in the literature, the BVM model shows a comparable accuracy achieved for typical human tissues. This model outperforms other nonlinear models in estimations of linear attenuation coefficients. This is the first study to clearly illustrate the …

Black Lives Examined: Black Nonfiction And The Praxis Of Survival In The Post-Civil Rights Era, Ariel D. Lawrence

Theses and Dissertations

The subject of my thesis project is black nonfiction, namely the essay, memoir, and autobiography, written by black authors about and during the Post-Civil Rights Era. The central goals of this work are to briefly investigate the role of genre analysis within the various subsets of nonfiction and also to exemplify the ways that black writers have taken key genre models and evolved them. Secondly, I aim to understand the historical, political, and cultural contributions of the Post-Civil Rights Era, which I mark as hitting its stride in 1968. It is not my desire to create a definitive historical framework …

Rational Design Of Allosteric Modulators Of Hemoglobin As Dual Acting Antisickling Agents, Piyusha P. Pagare

Theses and Dissertations

Intracellular polymerization of deoxygenated sickle hemoglobin (Hb S) remains the principal cause of the pathophysiology associated with sickle cell disease (SCD). Naturally occurring and synthetic allosteric effectors of hemoglobin (AEH) have been investigated as potential therapeutic agents for the treatment of SCD. Several aromatic aldehydes, including vanillin, have been studied previously as AEHs for their antisickling activities. Specifically, these compounds form Schiff- base adduct with Hb to stabilize the oxygenated (R) state, increase Hb affinity for O2 and concomitantly prevent the hypoxia-induced primary pathophysiology of Hb S polymerization and RBC sickling, in turn, ameliorating several of the cascading secondary adverse …

Enact In Disappearance, Stephanie Demer

Theses and Dissertations

Enact in Disappearance excavates the unseen through the medium of photography in order to chart a new strategy for knowing and communing with a complicated world.

Rotating Supporting Hyperplanes And Snug Circumscribing Simplexes, Ghasemali Salmani Jajaei

Theses and Dissertations

This dissertation has two topics. The rst one is about rotating a supporting

hyperplane on the convex hull of a nite point set to arrive at one of its facets.

We present three procedures for these rotations in multiple dimensions. The rst

two procedures rotate a supporting hyperplane for the polytope starting at a lower

dimensional face until the support set is a facet. These two procedures keep current

points in the support set and accumulate new points after the rotations. The rst

procedure uses only algebraic operations. The second procedure uses LP. In the third

procedure we rotate a …