Digital Commons Network^™

The Family Ismaridae Thomson (Hymenoptera, Diaprioidea): First Record For The Afrotropical Region With Description Of Fourteen New Species, Chang Jun Kim, Robert S. Copeland, David G. Notton

All Peer-Reviewed Publications

The family Ismaridae Thomson, 1858 is reported from the Afrotropical region for the first time. A total of 15 species are recognised, 14 of which are described as new: Ismarus africanus sp. n. from Cameroon, Kenya, Malawi, South Africa; I. apertus sp. n. from Kenya; I. bicolor sp. n. from Cameroon, Kenya; I. goodrichi sp. n. from Kenya; I. kakamegensis sp. n. from Kenya; I. kenyensis sp. n. from Kenya; I. laevigatus sp. n. from South Africa; I. madagascariensis sp. n. from Madagascar; I. minutus sp. n. from Kenya, Malawi, Zimbabwe; I. nigrofasciatus sp. n. from Malawi, Uganda; I. notaulicus …

Proximate Composition And In Vitro Protein Digestibility Of Extruded Aquafeeds Containing Acheta Domesticus And Hermetia Illucens Fractions, F. G. Irungu, C. M. Mutungi, A. K. Faraj, H. Affognon, S. Ekesi, D. Nakimbugwe, K. K.M. Fiaboe

All Peer-Reviewed Publications

Major protein sources for feed manufacture have become costly, and this has led to increased cost of products such as aquafeeds. This has dampening effect on fish production especially in developing countries, and has necessitated a search for alternative protein sources in processed feeds. The effects of extrusion on aquafeed blends containing fractions of adult cricket (Acheta domesticus) meal (ACM) or black soldier fly (Hermetia illucens) pre-pupae meal (BSFM) on proximate composition and in vitro protein digestibility were investigated. Extrusion resulted in higher contents of protein and nitrogen free extract, and lower contents of ether extract and crude fibre as …

Ingredients For Understanding Brain And Behavioral Evolution: Ecology, Phylogeny, And Mechanism, Stephen H. Montgomer, Adrian Currie, Dieter Lukas, Neeltje Boogert, Andrew Buskell, Fiona R. Cross, Sarah Jelbert, Shahar Avin, Rafael Mares, Ana F. Navarrete, Shuichi Shigeno, Corina J. Logan

All Peer-Reviewed Publications

Uncovering the neural correlates and evolutionary drivers of behavioral and cognitive traits has been held back by traditional perspectives on which correlations to look for-in particular, anthropocentric conceptions of cognition and coarse-grained brain measurements. We welcome our colleagues' comments on our overview of the field and their suggestions for how to move forward. Here, we counter, clarify, and extend some points, focusing on the merits of looking for the "best" predictor of cognitive ability, the sources and meaning of "noise," and the ways in which we can deduce and test meaningful conclusions from comparative analyses of complex traits.

Essential Oils Of Indigenous Plants Protect Livestock From Infestations Of Rhipicephalus Appendiculatus And Other Tick Species In Herds Grazing In Natural Pastures In Western Kenya, Wycliffe Wanzala, Ahmed Hassanali, Wolfgang Richard Mukabana, Willem Takken

All Peer-Reviewed Publications

The effects of formulated essential oils of Tagetes minuta and Tithonia diversifolia on Rhipicephalus appendiculatus infesting livestock were evaluated in semi-field experiments. Forty-five zebu cattle naturally infested with ticks were randomly selected from 15 herds, three animals from each. Of the three animals within each herd, one was treated with 1 g of petroleum jelly (control), one with 1 g of essential oil of T. minuta and one with 1 g of essential oil of T. diversifolia on the inner side of ear pinna, the preferred feeding site of R. appendiculatus. Tick infestation on each treated host animal was monitored …

Suitability Of Egg Hatching Conditions And Commonly Available Food Plants For Rearing The Long-Horned Grasshopper Ruspolia Differens Serville (Orthoptera: Tettigoniidae), G. Ssepuuya, C. M. Tanga, I. Yekko, F. Sengendo, C. T. Ndagire, K. K.M. Fiaboe, J. Karungi, D. Nakimbugwe

All Peer-Reviewed Publications

Efforts to promote sustainable production and processing of Ruspolia differens Serville (Orthoptera: Tettigoniidae) as a viable agribusiness model for enhancing food and nutrition security have gained momentum. However, the inexistence of rearing techniques adapted to this insect creates uncertainty regarding the effectiveness of up-scaling production. This study evaluated the effect of five temperatures (26, 28, 30, 32 and 34 °C) on egg development time, percentage hatchability and nymphal weight at hatching. It also evaluated the average weekly wet weight attained by R. differens and percentage survival during growth when reared at 30 °C on four different food plant diets. The …

Insect Net: A Novel Technology To Promote Integrated Pest Management On Horticultural Crops In Africa, T. Martin, M. Saidi, S. Niassy, S. Simon, F. Vidogbena, L. Parrot, S. Ekesi, E. Deletre, S. Subramanian, F. Assogba-Komlan, V. Baird, K. K.M. Fiaboe, M. Ngouajio, J. E. Simon, A. Ratnadass

All Peer-Reviewed Publications

Fruits and vegetables are important commodities in global agriculture. However, in sub-Saharan Africa, production is sub-optimal in terms of yield, quality and environmental health practices due to several constraints such as insect pests which reduce yields through direct damage, or indirectly as disease vectors often promoting microbial diseases. Pest control still relies mainly on chemicals with their associated risks of resistance selection and toxicity to humans and environment. Several alternatives including biopesticides, semiochemical and nets are being explored in pest management. Insect nets applied on tomatoes, cabbages, beans and leafy vegetables protect them from flies, butterflies, moths, albeit to a …

Effects Of Waste Stream Combinations From Brewing Industry On Performance Of Black Soldier Fly, Hermetia Illucens (Diptera: Stratiomyidae), Shaphan Y. Chia, Chrysantus M. Tanga, Isaac M. Osuga, Samira A. Mohamed, Fathiya M. Khamis, Daisy Salifu, Subramanian Sevgan, Komi K.M. Fiaboe, Saliou Niassy, Joop J.A. Van Loon, Marcel Dicke, Sunday Ekesi

All Peer-Reviewed Publications

Background: In recent years, there has been a rapidly growing demand for readily accessible substrates for mass production of Black Soldier Fly, Hermetia illucens Linnaeus. Beer production results in various by-products that typically end up in uncontrolled dumpsites constituting pollution problems, which merits urgent attention. The present study investigated whether the 12 formulated diets composed of brewers’ spent grains (BSGs), brewers’ yeast and cane molasses can serve as substrate for H. illucens production. Methods: Four different BSGs were selected and formulated into 12 diets, aiming at varying protein and net energy levels. The diets were offered to newly hatched (∼1 …

Morphological Re-Description And Molecular Identification Of Tabanidae (Diptera) In East Africa, Claire M. Mugasa, Jandouwe Villinger, Joseph Gitau, Nelly Ndungu, Marc Ciosi, Daniel Masiga

All Peer-Reviewed Publications

Biting flies of the family Tabanidae are important vectors of human and animal diseases across continents. However, records of Africa tabanids are fragmentary and mostly cursory. To improve identification, documentation and description of Tabanidae in East Africa, a baseline survey for the identification and description of Tabanidae in three eastern African countries was conducted. Tabanids from various locations in Uganda (Wakiso District), Tanzania (Tarangire National Park) and Kenya (Shimba Hills National Reserve, Muhaka, Nguruman) were collected. In Uganda, octenol baited F-traps were used to target tabanids, while NG2G traps baited with cow urine and acetone were employed in Kenya and …

Plasmodium Detection And Differentiation By Direct-On-Blood Pcr Nucleic Acid Lateral Flow Immunoassay: Development, Validation, And Evaluation, Johanna M. Roth, Laura De Bes, Patrick Sawa, George Omweri, Victor Osoti, Boris Oberheitmann, Henk D.F.H. Schallig, Pètra F. Mens

All Peer-Reviewed Publications

Decreasing malaria transmission warrants the search for highly sensitive point-of-care diagnostics, especially in resource-limited settings. The direct-on-blood PCR nucleic acid lateral flow immunoassay (db-PCR-NALFIA) is a simplified PCR-based technique with a lateral flow readout that does not require sample preparation. Two duplex db-PCR-NALFIAs were developed: a pan-Plasmodium/Plasmodium falciparum (pan/P. falciparum) and a pan-Plasmodium/Plasmodium vivax (pan/P. vivax) assay. Confirmed positive samples (n = 61) and negative controls (n = 40) were used for laboratory validations. A prospective field evaluation of the pan/P. falciparum assay was performed in Kenya (n = 300). In the laboratory validation, sensitivity and specificity of the pan/P. …

A Teacher Goes Gothic: Walter White, Heisenberg And The Dark Revenge Of Science, J. Patrick Mcgrail, Ewa Mcgrail, Alicja Rieger

Research, Publications & Creative Work

Much has been written on the natures and personalities of teachers in educational research and publications (Carter, 2009; Beck, 2012; Bulman, 2015; Dalton, 2013; Gillard, 2012; Kelly & Caughlan, 2011). However, mass media can have a powerful influence on how people see teachers. The television series Breaking Bad (Gilligan, 2007-2013) and its representation of teachers, has contributed a unique – if warped -perspective on the subject of teachers and teaching in America. In this article, we argue that three important Gothic and mythic fables from literature are harbingers of Walter White and his transformation – the Faust legend, as told …

Introductory Statistics, Barbara Illowsky, Susan Dean

Open Access Textbooks

Introductory Statistics follows scope and sequence requirements of a one-semester introduction to statistics course and is geared toward students majoring in fields other than math or engineering. The text assumes some knowledge of intermediate algebra and focuses on statistics application over theory. Introductory Statistics includes innovative practical applications that make the text relevant and accessible, as well as collaborative exercises, technology integration problems, and statistics labs.

How To Prepare Interprofessional Teams In Two Weeks: An Innovative Education Program Nested In Telehealth, Tina S. Haney, Karen Kott, Carolyn M. Rutledge, Bruce Britton, Christianne N. Fowler, Rebecca D. Poston

Ellmer School of Nursing Faculty Publications

PROBLEM:

Preparing health professional students for interprofessional collaborative practice, especially at a distance where provider shortages prevail remains difficult.

APPROACH:

A two-week interprofessional education (IPE) immersion experience preparing students from 11 disciplines and four universities was implemented. Week-one, using online technology, students develop/present an interprofessional careplan for a complex patient. Students then meet face-to-face to conduct group interviews with two standardized patient dyads. Week-two, students develop a website for use of the patient dyads. Websites are presented to faculty and fellow students via an online virtual meeting space.

OUTCOMES:

To date, 594 students have participated demonstrating capacity to: 1.effectively engage …

The Practical Utility And Suitability Of Email Interviews In Qualitative Research, Janice E. Hawkins

Ellmer School of Nursing Faculty Publications

Interviews with key informants are the most common means of data collection in qualitative descriptive research. Researchers have historically preferred face-to-face interviews but advances in technology have resulted in more options, including email exchanges, to conduct interviews. This article examines the practical utility and suitability of the email interview in qualitative research. The author will share personal experiences from a recent qualitative study involving email interviews of nurse educators. The purpose of the study was to describe the experiences of nurse educators in developing and implementing concurrent enrollment ADN-BSN programs. Interviews of nurse educators describing their experiences of developing and …

The Veil Uplifted, Or, The Bible Its Own Interpreter : A Series Of Bible Readings, Hannah Whitall Smith

Heritage Material

No abstract provided.

From The Workshop To The Classroom - Examining Apprentice Perceptions, Anne Marie Mccarrick, Audrey Mccann, Odran Reid

Conference Papers

From the Workplace to the Classroom – Examining Apprentice Perceptions

The Irish government has reiterated its commitment to apprenticeships and how these form a central plank of the Further Education and Training Strategy. One of the main goals of the Action Plan for Education is to ‘create a greater diversity of learning opportunities beyond school’. Indeed, an increase of 19% in apprenticeship registrations took place between 2015 and 2016, and it is planned that this will grow by more than 30% by the year 2020.

This paper aims to identify both positive and negative perceptions of apprentices’ experiences as they …

Characterizing Curiosity-Related Behavior In Bottlenose (Tursiops Truncatus) And Roughtoothed (Steno Bredanensis) Dolphins, Malin Lilley, Amber J. De Vere, Deirdre Yeater, Stan A. Kuczaj Ii

Psychology Faculty Publications

Dolphins are frequently described as curious animals; however, there have been few systematic investigations of how dolphins behave when they are curious and the extent to which individual differences in curiosity exist in dolphins. Previous research has described individual differences in dolphins’ frequency of interactions with environmental enrichment as well as quantifying curiosity-related traits of dolphins via personality assessments, though behavioral observation and trait rating components have not been part of the same study. The present study describes two different experiments designed to elicit curiosity in 15 bottlenose (Tursiops truncatus) and 6 rough-toothed (Steno bredanensis) dolphins. …

Role Of Sphingosine-1-Phosphate Receptors In Cytokine And Chemokine Production By Glia, Jean Moon

Theses and Dissertations

About 1 in 10 newly diagnosed HIV cases in the United States are attributed to injection drug abuse. Opiate abuse exacerbates HIV disease progression in the central nervous system by disrupting glial function and significantly augmenting glial-derived pro-inflammatory mediators. Astroglia and microglia exposed to viral proteins, such as transactivator of transcription (Tat), become activated leading to release of a large number of cytokines and chemokines and a positive loop of neuro-inflammation. Despite effective antiretroviral therapy, persistent inflammation and immune activation affect HIV-infected individuals. A potential alternative target is sphingosine 1-phosphate receptor 1 (S1PR1) which is known to play a role …

Activation Of Trpv1 By Capsaicin Regulates Enac, Alexander Saffran

Theses and Dissertations

ENaC is a constitutively open heterotrimeric channel which regulates Na⁺ transport in tight epithelia of the kidney, lungs, colon and anterior tongue containing fungiform taste buds. The amiloride-sensitive ENaC is comprised of aβg subunits. Humans express an additional subunit, the d subunit. Therefore, humans contain both aβg-ENaC and dβg-ENaC functional channels. Relative to aβg-ENaC, the dβg-ENaC is 10-fold less sensitive to amiloride. In the mammalian anterior tongue, ENaC is expressed in fungiform salt sensing taste receptor cells and is the Na⁺-specific salt taste receptor. In mammals, salt elicits an inverted U shaped behavioral response. Lower concentrations of …

Three Essays On Maternal And Child Health, Mandar V. Bodas

Theses and Dissertations

This dissertation is a collection of three separate essays on the health of women and children. In the first essay, I along with my co-authors, analyzed the impact of two large, national-level health policies (the Janani Suraksha Yojana (JSY) and the National Rural Health Mission (NRHM)) on maternal health outcomes (proportion of institutional deliveries) in India. We used data from the India Human Development Survey (IHDS) and found that the JSY and the NRHM had a greater impact on institutional deliveries in high-focus states. We also found that the conditions of the public health facilities, did not change after the …

Prescription Drug Monitoring Programs And Opioid Poisoning: Evaluating The Impact Of Prescriber Use Mandates On Prescription Opioid Poisoning Emergency Department Visits, Sarah Almanie

Theses and Dissertations

Introduction: Prescription drug monitoring programs (PDMPs) are one strategy established to curb the prescription opioid abuse epidemic. Prescriber use mandates has emerged as a promising practice to increase PDMPs impact on prescription opioid abuse; however, evidence of its effectiveness has not yet been established. Kentucky was the first state to implement comprehensive prescriber use mandates in July 2012.

Objective: To assess the relationship between prescriber use mandates policy and emergency department (ED) visits related to prescription opioid poisoning among adults in Kentucky and

North Carolina. Secondary aim: to evaluate the economic impact of prescriber use mandates in Kentucky.

Methods: A …

Branched Short Chain Fatty Acid Isovaleric Acid Causes Smooth Muscle Relaxation Via Camp/Pka Pathway, Inhibits Gastrointestinal Motility, And Disrupts Peristaltic Movement, Bryan Adam Blakeney

Theses and Dissertations

Isovaleric Acid (IVA) is a 5-carbon branched chain fatty acid present in fermented foods and produced by the fermentation of leucine by colonic bacteria. IVA activates G-protein coupled receptors such as FFAR2, FFAR3, and OR51E1 known to be expressed on enteric neurons and enteroendocrine cells. We previously reported that the shorter, straight chain fatty acids acetate, propionate and butyrate, differentially affect colonic propulsion; however, the effect of branched chain fatty acids on gastrointestinal motility is unknown. We hypothesize that IVA relaxes smooth muscle in a cAMP/PKA dependent manner by direct action on smooth muscle cells. IVA will also decrease peristalsis …

Improving The Conservation Of A Cryptic Endangered Freshwater Mussel (Parvaspina Collina) Through The Use Of Environmental Dna And Species Distribution Modeling, Bonnie A. Roderique

Theses and Dissertations

Conservation efforts that involve habitat protection, population augmentation, and species reintroductions require knowledge of the habitat requirements, distribution, and abundance of a species—information that can be challenging to acquire, especially for rare organisms with patchy distributions. In this thesis, I develop a protocol for the use of environmental DNA (eDNA) and create a Species Distribution Model for the endangered James spinymussel, Parvaspina collina (Unionidae). The results of this work show that eDNA is a robust tool for identifying species presence but not for estimating the relative abundance of populations. This study found that P. collina’s distribution is influenced by abiotic …

Motion-Induced Artifact Mitigation And Image Enhancement Strategies For Four-Dimensional Fan-Beam And Cone-Beam Computed Tomography, Matthew J. Riblett

Theses and Dissertations

Four dimensional imaging has become part of the standard of care for diagnosing and treating non-small cell lung cancer. In radiotherapy applications 4D fan-beam computed tomography (4D-CT) and 4D cone-beam computed tomography (4D-CBCT) are two advanced imaging modalities that afford clinical practitioners knowledge of the underlying kinematics and structural dynamics of diseased tissues and provide insight into the effects of regular organ motion and the nature of tissue deformation over time. While these imaging techniques can facilitate the use of more targeted radiotherapies, issues surrounding image quality and accuracy currently limit the utility of these images clinically.

The purpose of …

Use Of Surface Enhanced Raman Spectroscopy For The Detection Of Bioactive Lipids, Christopher M. Ohlhaver

Theses and Dissertations

The detection and analysis of lipids in biological matrices for clinical applications poses many challenges, but rapid and reliable detection will prove invaluable for clinical diagnosis. Herein, we report the application of drop-casted Ag nanoplatelets as surface enhanced Raman scattering (SERS) substrates for qualitative detection of 20-hydroxyeicosatetraenoic acid (20-HETE), which is a potential biomarker for diagnosis of hypertensive disorders. Biomarker peaks of 20-HETE can be reliably detected and differentiated from those of the structurally similar lipids (arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid) commonly found in human blood, even 1 pM concentrations. Additionally, one study mixed 20-HETE with three structurally …

Placental Eicosanoids And Sphingolipids In Preeclampsia, Daniel T. Reep

Theses and Dissertations

Placental dysfunction is implicated in the pathogenesis of preeclampsia. Chemical signals between the placenta and maternal circulation are a suspect cause of endothelial dysfunction and maternal hypertension. This study examined select lipid mediators of inflammation produced by the placenta. Patients were recruited from Virginia Commonwealth University’s pregnancy clinics and placentas were collected at delivery. Forty-eight-hour explant cultures of villous placental tissue were used to model lipid production. Electrospray ionization mass spectrometry was used to quantify concentrations of free lipids in the culture media. Bicinchoninic acid assays were performed to quantify protein in each culture for normalization of lipid data. After …

Identification Of Taxonomic And Functional Ichthyofaunal Zones Within The James River Basin, Virginia, Joseph L. Noel

Theses and Dissertations

Environmental gradients structure ichthyofaunal communities longitudinally along river networks via the selective filtering of species’ traits. In many instances, these environmental influences have created distinct zones of co-occurring fish species. Zonation studies have most often been conducted with taxonomic data (species x site matrices), but the increasing availability of functional trait data creates an opportunity to build more rigorous understanding of species’ co-occurrence patterns. Notably, zonation studies that use taxonomic data may not reveal the same patterns as studies based on trait data. In this study, we tested for distinct ichthyofaunal zonation in James River Basin, VA using a combination …

Economic Burden Of Renal Cell Carcinoma (Rcc) And Treatment Patterns, Overall Survival And Healthcare Costs Among Older Metastatic Rcc Patients, Hrishikesh P. Kale

Theses and Dissertations

Background

Renal cell carcinoma (RCC) is the most common type of kidney cancer. Patients diagnosed with metastatic RCC (mRCC) have shorter overall survival compared to those diagnosed at earlier stages. Several targeted therapies, which cost from $7,000 - $16,000 per month have been approved since 2005 to treat mRCC. In addition, there is a growing interest in the use of cytoreductive nephrectomy (CN) with targeted therapies among mRCC patients. However, little is known regarding the economic burden of RCC and role of CN and prescribing patterns of targeted therapies among older mRCC patients.

Objectives

1) To assess the economic burden …

Fibronectin Mechanics And Signaling In Tgf-Β1-Induced Epithelial To Mesenchymal Transition, Lauren Griggs

Theses and Dissertations

Epithelial to Mesenchymal Transition (EMT) is a dynamic process by which a distinct change in the phenotype and function of epithelial cells render them as mesenchymal cells. Characteristics of mesenchymal cells include the ability to invade, increased migratory kinetics and heightened resistance to apoptosis. Therefore, there is a strong need to fully understand the mechanism for the induction of EMT in pathological conditions such as carcinoma progression. Recent advances highlight two pivotal contributors, soluble growth factor (gf) signals, and mechanical signals, in the process. However, to date, no clear mechanism exists linking the two in epithelial transdifferentiation. Transforming Growth Factor-β1 …

Investigating The Role Of Nicotinic Acetylcholine Receptor Agonists In Lung Cancer Progression And Chemosensitivity In The Context Of Treating Chemotherapy-Induced Peripheral Neuropathy, Sarah L. Kyte

Theses and Dissertations

While cancer chemotherapy continues to significantly contribute to the number of cancer survivors, exposure to these drugs can often result in chemotherapy-induced peripheral neuropathy (CIPN), a consequence of peripheral nerve fiber dysfunction or degeneration. CIPN is characterized by sensory symptoms in the hands and feet, such as numbness, burning, and allodynia, resulting in an overall decrease in quality of life. Paclitaxel (Taxol), a microtubule poison that is commonly used to treat breast, lung, and ovarian cancers, has been found to cause CIPN in 59-78% of cancer patients. There is currently no effective preventative or therapeutic treatment for this side effect, …

Association Between Warfarin Adherence Trajectories, Hospitalization Risk, And Healthcare Utilization Among Medicare Patients With Atrial Fibrillation: A Group-Based Trajectory Modelling Approach, Mai Alhazami

Theses and Dissertations

Introduction: Warfarin is the most commonly prescribed drug for stroke prevention among Atrial Fibrillation (AF) patients, especially in older adult populations, but medication nonadherence reduces its effectiveness in clinical practice. Group Based Trajectory Models (GBTM) have been used to identify distinct patterns of adherence behavior related to various medications and understand the patient characteristics associated with each trajectory. The objectives of the study were: 1) Describe trajectories of warfarin adherence among Medicare AF patients, 2) Assess impact of adherence trajectories on AF-related hospitalization, 3) Estimate the AF-related direct costs for each adherence trajectory group.

Methods: We identified elderly AF patients …