Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2018

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 166411 - 166440 of 170095

Full-Text Articles in Entire DC Network

Scarcity In The Twenty-First Century: How The Resource Nexus Affects Management, Simon J. D. Schillebeeckx, Mark Workman, Charles Dean Jan 2018

Scarcity In The Twenty-First Century: How The Resource Nexus Affects Management, Simon J. D. Schillebeeckx, Mark Workman, Charles Dean

Research Collection Lee Kong Chian School Of Business

Since theadvent of the 21st century and especially since the food andfinancial crisis in 2008, concerns about natural resource availability haveresurfaced. While scarcity concerns date back hundreds of years and arefoundational to economics, how scarcity is interpreted or framed has evolved significantlyin the last two centuries. In this chapter, we recount the evolving scarcity discourseand specifically address the most recent iteration that centres on the idea ofa resource nexus. While significant attention to the nexus has been paid bypolicy-makers and scholars interested in especially water, management scholarshave so far remained absent from these debates. Given recent calls to address grand …


The Management Of Natural Resources: An Overview And Research Agenda, Gerard George, Simon J.D. Schillebeeckx, Teng Lit Liak Jan 2018

The Management Of Natural Resources: An Overview And Research Agenda, Gerard George, Simon J.D. Schillebeeckx, Teng Lit Liak

Research Collection Lee Kong Chian School Of Business

Natural resources underpin the foundation of human activity. Individuals and organizations consume vast amounts of natural resources as a matter of routine without much cognizance of their continued availability in the future or the true cost of a depleting natural resource. Over the past decades of industrial activity, organizations, communities, and nations have acted to protect their interests by investing in and securing their supplies of natural resources that support economic growth. An industrial complex, now variously termed as extractive industries, supplies crucial non-renewable natural resources such as oil and coal for energy or iron and aluminum for construction. Our …


Sleep And Work: The Interactive Mechanism [睡眠与工作:相互作用机制], Xiaotian Sheng, Zihan Liu, Xichao Zhang, Heng Guo, Shu Da, Shiyi Zhou Jan 2018

Sleep And Work: The Interactive Mechanism [睡眠与工作:相互作用机制], Xiaotian Sheng, Zihan Liu, Xichao Zhang, Heng Guo, Shu Da, Shiyi Zhou

Research Collection Lee Kong Chian School Of Business

Sleep-related problems are becoming increasingly severer for workers, which draws great attention from researchers. Based on important empirical researches in recent years, we finish a systematic summary of the conceptualization, measurement, antecedents and consequences of sleep in the workplace. In general, researches measure individual’s sleep from two dimensions including sleep duration and sleep quality. Objective records and subjective reports are both used to collect data. Antecedents of sleep problems can be classified as environmental factors, cognitive factor and behavioral factors. Unsatisfactory sleep also has a negative influence on the psychological state and behaviors of workers, which may lead to workplace …


Projecting Lower Competence To Maintain Moral Warmth In The Avoidance Of Prosocial Requests, Peggy J. Liu, Stephanie C. Lin Jan 2018

Projecting Lower Competence To Maintain Moral Warmth In The Avoidance Of Prosocial Requests, Peggy J. Liu, Stephanie C. Lin

Research Collection Lee Kong Chian School Of Business

When faced with prosocial requests, consumers face a difficult decision between taking on the request’s burden or appearing unwarm (unkind, uncaring). We propose that the desire to refuse such requests while protecting a morally warm image leads consumers to under-represent their competence. Although consumers care strongly about being viewed as competent, five studies showed that they downplayed their competence to sidestep a prosocial request. This effect occurred across both self-reported and behavioral displays of competence. Further, the downplaying competence effect only occurred when facing an undesirable prosocial request, not a similarly undesirable proself request. The final studies showed that people …


Status Reports Of The Fisheries And Aquatic Resources Of Western Australia 2016/17. State Of The Fisheries, Daniel J. Gaughan, K. Santoro Jan 2018

Status Reports Of The Fisheries And Aquatic Resources Of Western Australia 2016/17. State Of The Fisheries, Daniel J. Gaughan, K. Santoro

Status Reports of the Fisheries and Aquatic Resources

The Status Reports of the Fisheries and Aquatic Resources of Western Australia (SRFAR) provide an annual update on the state of the fish stocks and other aquatic resources of Western Australia (WA). These reports outline the most recent assessments of the cumulative risk status for each of the aquatic resources (assets) within WA’s six Bioregions using an Ecosystem Based Fisheries Management (EBFM) approach.


'What’S On Your Mind?' The Only Necessary Question In Spiritual Care, Austyn Snowden, Elizabeth Anne Lobb, Susanne Schmidt, Ashley M. Swing, Pamela Logan, Catherine Macfarlane Jan 2018

'What’S On Your Mind?' The Only Necessary Question In Spiritual Care, Austyn Snowden, Elizabeth Anne Lobb, Susanne Schmidt, Ashley M. Swing, Pamela Logan, Catherine Macfarlane

Medical Papers and Journal Articles

Around the world, chaplains provide specialist spiritual care for people with complex healthcare needs. If the nature of chaplain interventions was better understood then multidisciplinary colleagues could both improve their own skills in spiritual care and better understand when to refer people to chaplains. A survey was constructed to establish what aspects of the chaplain/patient relationship were most important for patients in Scotland and Australia. Outcomes were measured with the Scottish Patient Reported Outcome Measure (Scottish PROM©). Results from 610 respondents showed the strongest correlation was between ‘being able to talk about what is on my mind’ and the Scottish …


Increasing The Knowledge, Identification And Treatment Of Osteoporosis Through Education And Shared Decision-Making With Residents Living In A Retirement Village Community, Jane Anderson-Wurf, Catherine Harding, Alexa Seal Jan 2018

Increasing The Knowledge, Identification And Treatment Of Osteoporosis Through Education And Shared Decision-Making With Residents Living In A Retirement Village Community, Jane Anderson-Wurf, Catherine Harding, Alexa Seal

Medical Papers and Journal Articles

Objective: This pilot study explored whether individual goal setting in a retirement village setting could improve strategies to strengthen bones in an ageing population and help prevent osteoporosis.

Methods: A two-phased osteoporosis prevention program was developed, piloted and evaluated involving a group education session followed by the development of individualised Bone Plans based upon personal understanding of individual fracture risk and lifestyle factors.

Results: A significant improvement in knowledge and understanding of factors to prevent and manage osteoporosis was achieved, and changes in lifestyle behaviours were sustained at six months.

Conclusion: Success was due to education by specialist medical and …


Primary Goals, Information-Giving And Men's Understanding: A Qualitative Study Of Australian And Uk Doctors' Varied Communication About Psa Screening, Kristen Pickles, Stacy M. Carter, Lucie Rychetnik, Kirsten Mccaffery, Vikki A. Entwistle Jan 2018

Primary Goals, Information-Giving And Men's Understanding: A Qualitative Study Of Australian And Uk Doctors' Varied Communication About Psa Screening, Kristen Pickles, Stacy M. Carter, Lucie Rychetnik, Kirsten Mccaffery, Vikki A. Entwistle

Medical Papers and Journal Articles

Objectives: (1) To characterise variation in general practitioners’ (GPs’) accounts of communicating with men about prostate cancer screening using the prostate-specific antigen (PSA) test, (2) to characterise GPs’ reasons for communicating as they do and (3) to explain why and under what conditions GP communication approaches vary.

Study design and setting: A grounded theory study. We interviewed 69 GPs consulting in primary care practices in Australia (n=40) and the UK (n=29).

Results: GPs explained their communication practices in relation to their primary goals. In Australia, three different communication goals were reported: to encourage asymptomatic men to either have a PSA …


The Teaching And Learning Of Health Advocacy In An Australian Medical School, Arabelle M. Douglas, Donna B. Mak, Caroline Bulsara, David J. Macey, Indira V.M Samarawickrema Jan 2018

The Teaching And Learning Of Health Advocacy In An Australian Medical School, Arabelle M. Douglas, Donna B. Mak, Caroline Bulsara, David J. Macey, Indira V.M Samarawickrema

Medical Papers and Journal Articles

Objectives: To determine if medical graduates from an Australian university are educated and skilled in health advocacy for their future practice with patients and the wider community.

Methods: The authors used an exploratory mixed methodology starting with curriculum mapping of the medical curriculum, followed by key informant interviews with the University of Notre Dame, School of Medicine academics (n = 6) and alumni (n = 5) on teaching/learning and practice of health advocacy. The final stage consisted of a cross-sectional survey on teaching/learning health advocacy among third and fourth (final) year medical students (N = 195).

Results: The medical curriculum …


Community Peer-Led Falls Prevention Presentations: What Do The Experts Suggest?, Linda Khong, Richard G. Berlach, Keith D. Hill, Anne-Marie Hill Jan 2018

Community Peer-Led Falls Prevention Presentations: What Do The Experts Suggest?, Linda Khong, Richard G. Berlach, Keith D. Hill, Anne-Marie Hill

IHR Papers and Journal Articles

Falls among older adults are a major problem. Despite considerable progress in falls prevention research, older adults often show low motivation to engage in recommended preventive strategies. Peer-led falls prevention education for older adults may have potential for bridging the research evidence-practice gap, thereby promoting the uptake of falls prevention strategies. We evaluated peer educators’ presentations of falls prevention education to community-dwelling older adults in regard to established criteria that were consistent with adult learning principles, the framework of health behaviour change, falls prevention guidelines, and recommendations for providing falls prevention information. We conducted a within-stage mixed model study using …


Cauliflower Ear - A Minimally Invasive Treatment Method In A Wrestling Athlete: A Case Report, Josef Haik, Or Givol, Rachel Kornhaber, Michelle Cleary, Hagit Ofir, Moti Harats Jan 2018

Cauliflower Ear - A Minimally Invasive Treatment Method In A Wrestling Athlete: A Case Report, Josef Haik, Or Givol, Rachel Kornhaber, Michelle Cleary, Hagit Ofir, Moti Harats

Health Sciences Papers and Journal Articles

Acute auricular hematoma can be caused by direct blunt trauma or other injury to the external ear. It is typically seen in those who practice full contact sports such as boxing, wrestling, and rugby. “Cauliflower ear” deformity, fibrocartilage formation during scarring, is a common complication of auricular hematomas. Therefore, acute drainage of the hematoma and postprocedural techniques for preventing recurrence are necessary for preventing the deformity. There are many techniques although no superior method of treatment has been found. In this case report, we describe a novel method using needle aspiration followed by the application of a magnet and an …


The General Motor Ability Hypothesis: An Old Idea Revisited, Beth Hands, Fleur Mcintyre, Helen Parker Jan 2018

The General Motor Ability Hypothesis: An Old Idea Revisited, Beth Hands, Fleur Mcintyre, Helen Parker

Health Sciences Papers and Journal Articles

While specific motor abilities have become a popular explanation for motor performance, the older, alternate notion of a general motor ability should be revisited. Current theories lack consensus, and most motor assessment tools continue to derive a single composite score to represent motor capacity. In addition, results from elegant statistical procedures such as higher order factor analyses, cluster analyses, and Item Response Theory support a more global motor ability. We propose a contemporary model of general motor ability as a unidimensional construct that is emergent and fluid over an individual’s lifespan, influenced by both biological and environmental factors. In this …


Manipulating Field Dimensions During Small-Sided Games Impacts The Technical And Physical Profiles Of Australian Footballers, Brock Fleay, Christopher Joyce, Harry Banyard, T Carl Woods Jan 2018

Manipulating Field Dimensions During Small-Sided Games Impacts The Technical And Physical Profiles Of Australian Footballers, Brock Fleay, Christopher Joyce, Harry Banyard, T Carl Woods

Health Sciences Papers and Journal Articles

This study investigated the effect of manipulating field dimensions on the technical and physical profiles of Australian football (AF) players during small-sided games (SSGs). A total of 40 male players (23.9 ± 3.5 y) participated in three, five-a-side SSGs; defined as ‘small’ (20m x 30m; 600m2), ‘medium’ (30m x 40m; 1200m2), and ‘large’ (40m x 50m; 2000m2). Notational analyses enabled the quantification of technical skill indicators, while physical activity profiles were measured using microtechnology, resulting in 18 criterion variables. A multivariate analysis of variance modelled the main effect of field dimension on the criterion …


Monitoring And Managing Fatigue In Basketball, Toby Edwards, Tania Spiteri, Benjamin Piggott, Joshua Bonhotal, G Gregory Haff, Christopher Joyce Jan 2018

Monitoring And Managing Fatigue In Basketball, Toby Edwards, Tania Spiteri, Benjamin Piggott, Joshua Bonhotal, G Gregory Haff, Christopher Joyce

Health Sciences Papers and Journal Articles

The sport of basketball exposes athletes to frequent high intensity movements including sprinting, jumping, accelerations, decelerations and changes of direction during training and competition which can lead to acute and accumulated chronic fatigue. Fatigue may affect the ability of the athlete to perform over the course of a lengthy season. The ability of practitioners to quantify the workload and subsequent fatigue in basketball athletes in order to monitor and manage fatigue levels may be beneficial in maintaining high levels of performance and preventing unfavorable physical and physiological training adaptations. There is currently limited research quantifying training or competition workload outside …


Literature Review: Anthropometric, Strength And Physical Capacities Of Senior And Junior Australian Footballers, Ashley Cripps, Ysabel Jacob, James Walker, Benjamin Piggott Jan 2018

Literature Review: Anthropometric, Strength And Physical Capacities Of Senior And Junior Australian Footballers, Ashley Cripps, Ysabel Jacob, James Walker, Benjamin Piggott

Health Sciences Papers and Journal Articles

This study demonstrates that senior Australian Football players are heavier and possess superior strength characteristics without any meaningful difference in aerobic capacities when compared to under 18 players.

The aim of this study was to compare the anthropometric and physical characteristics of state based junior and senior Australian Football (AF) players. Thirty-One League (age 23.7 ± 2.6 years), 19 Development League (DL) (age 20.5 ± 1.9 years), and 34 Under 18 (U18) players (age 17.4 ± 0.7 years) were recruited from a single AF club. Assessments included height and mass, upper body (bench press and weighted pull-up) and lower body …


Is There A Link Between Vitamin B And Multiple Sclerosis?, Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L. Blatch, Vasso Apostolopoulos Jan 2018

Is There A Link Between Vitamin B And Multiple Sclerosis?, Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L. Blatch, Vasso Apostolopoulos

Health Sciences Papers and Journal Articles

Background: Damage to the myelin sheath (demyelination) is one of the main manifestations of multiple sclerosis (MS). Interestingly, both MS and vitamin B deficiencies result in severe myelin degeneration, leading to loss in neuronal signal transmission.

Objective: Deficiency in vitamin B complex vary, although common symptoms include fatigue, increased oxidative stress, inflammation and demyelination. In particular, vitamin B12 (cobalamin) has had increased attention for its role in the methylation process, involvement in myelination and remyelination, and reversal of MS symptoms.

Method: Here, we discuss the role of vitamin B complex (B1, B2, B3, B4, B5, B6, B7, B9, B12) in …


Cosmetic Outcome As Rated By Patients, Doctors, Nurses And Bcct.Core Software Assessed Over 5 Years In A Subset Of Patients In The Targit-A Trial, Tammy Corica, Anna K. Nowak, Christobel M. Saunders, Max K. Bulsara, Mandy Taylor, Norman R. Williams, Mohammed Keshtgar, David J. Joseph, Jayant S. Vaidya Jan 2018

Cosmetic Outcome As Rated By Patients, Doctors, Nurses And Bcct.Core Software Assessed Over 5 Years In A Subset Of Patients In The Targit-A Trial, Tammy Corica, Anna K. Nowak, Christobel M. Saunders, Max K. Bulsara, Mandy Taylor, Norman R. Williams, Mohammed Keshtgar, David J. Joseph, Jayant S. Vaidya

Health Sciences Papers and Journal Articles

Background: The purpose of this research was to assess agreement between four rating systems of cosmetic outcome measured in a subset of patients with early breast cancer participating in the randomised TARGIT-A trial. TARGIT-A compared risk-adapted single-dose intra-operative radiotherapy (TARGIT-IORT) to whole breast external beam radiotherapy (EBRT).

Methods: Patients, their Radiation Oncologist and Research Nurse completed a subjective cosmetic assessment questionnaire before radiotherapy and annually thereafter for five years. Objective data previously calculated by the validated BCCT.core software which utilizes digital photographs to score symmetry, colour and scar was also used. Agreement was assessed by the Kappa statistic and longitudinal …


Adolescents' Self-Reported Motor Assessments May Be More Realistic Than Those Of Their Parents, Fleur Mcintyre, Beth Hands Jan 2018

Adolescents' Self-Reported Motor Assessments May Be More Realistic Than Those Of Their Parents, Fleur Mcintyre, Beth Hands

Health Sciences Papers and Journal Articles

Introduction: Adolescents' motor competence influences their physical, social and emotional development. Parent-reported assessments may not be truly representative of their adolescent's motor difficulties. This study examined the congruency between parent- and self-reported motor competence in 133 parent-adolescent dyads.

Method: The adolescent-reported Adolescent Motor Competence Questionnaire (AMCQ; ≤83) and the parent-reported Developmental Coordination Disorder Questionnaire 2007 (DCDQ-07; ≤57) cut scores classified 133 (Mage = 14.5 years) adolescents into high and low motor competence. Parents also completed the Swanson, Nolan and Pelham IV (SNAP-IV) for descriptive purposes.

Findings: A moderate correlation (r = 0.56, P < 0.001) was found between the AMCQ and the DCDQ-07 scores. Overall, 42 low motor competence cases were identified by both measures (AMCQ and DCDQ-07). Parents identified more boys (11) than girls (9) with low motor competence, whereas more female adolescents (22) self-reported low motor competence than boys (18). A high proportion agreement (0.82) was seen, which was principally due to the 91 (68.4% of sample) high motor competence case agreements.

Conclusion: Parents identified fewer motor …


Risk Of High-Grade Serous Ovarian Cancer Associated With Pelvic Inflammatory Disease, Parity And Breast Cancer, Louise Stewart, Katrina Spilsbury, Susan Jordan, Colin Stewart, C. D'Arcy J. Holman, Aime Powell, Joanne Reekie, Paul Cohen Jan 2018

Risk Of High-Grade Serous Ovarian Cancer Associated With Pelvic Inflammatory Disease, Parity And Breast Cancer, Louise Stewart, Katrina Spilsbury, Susan Jordan, Colin Stewart, C. D'Arcy J. Holman, Aime Powell, Joanne Reekie, Paul Cohen

Health Sciences Papers and Journal Articles

Background: Ovarian carcinoma is not a single disease, but rather a collection of subtypes with differing molecular properties and risk profiles. The most common of these, and the subject of this work, is high-grade serous ovarian carcinoma (HGSC).

Methods: In this population-based study we identified a cohort of 441,382 women resident in Western Australia who had ever been admitted to hospital in the State. Of these, 454 were diagnosed with HGSC. We used Cox regression to derive hazard ratios (HRs) comparing the risk of disease in women who had each of a range of medical diagnoses and surgical procedures with …


Intense Exercise For Survival Among Men With Metastatic Castrate-Resistant Prostate Cancer (Interval-Gap4): A Multicentre, Randomized, Controlled Phase Iii Study Protocol, Robert U. Newton, Stacey A. Kenfield, Nicolas H. Hart, June M. Chan, Kerry S. Courneya, James Catto, Stephen P. Finn, Rosemary Greenwood, Daniel C. Hughes, Lorelei Mucci, Stephen R. Plymate, Stephan F.E Plaet, Emer M. Guinan, Erin L. Van Blarigan, Orla Casey, Mark Buzza, Sam Gledhill, Li Zhang, Daniel A. Galvao, Charles J. Ryan, Fred Saad Jan 2018

Intense Exercise For Survival Among Men With Metastatic Castrate-Resistant Prostate Cancer (Interval-Gap4): A Multicentre, Randomized, Controlled Phase Iii Study Protocol, Robert U. Newton, Stacey A. Kenfield, Nicolas H. Hart, June M. Chan, Kerry S. Courneya, James Catto, Stephen P. Finn, Rosemary Greenwood, Daniel C. Hughes, Lorelei Mucci, Stephen R. Plymate, Stephan F.E Plaet, Emer M. Guinan, Erin L. Van Blarigan, Orla Casey, Mark Buzza, Sam Gledhill, Li Zhang, Daniel A. Galvao, Charles J. Ryan, Fred Saad

Health Sciences Papers and Journal Articles

Introduction: Preliminary evidence supports the beneficial role of physical activity on prostate cancer outcomes. This phase III randomised controlled trial (RCT) is designed to determine if supervised high-intensity aerobic and resistance exercise increases overall survival (OS) in patients with metastatic castrate-resistant prostate cancer (mCRPC).

Methods and analysis: Participants (n=866) must have histologically documented metastatic prostate cancer with evidence of progressive disease on androgen deprivation therapy (defined as mCRPC). Patients can be treatmentnaive for mCRPC or on first-line androgen receptor-targeted therapy for mCRPC (ie, abiraterone or enzalutamide) without evidence of progression at enrolment, and with no prior chemotherapy for mCRPC. Patients …


Key Features Of Palliative Care Service Delivery To Indigenous Peoples In Australia, New Zealand, Canada And The United States: A Comprehensive Review, Shaouli Shahid, Emma V. Taylor, Shelley Cheetham, John A. Woods, Samar M. Aoun, Sandra C. Thompson Jan 2018

Key Features Of Palliative Care Service Delivery To Indigenous Peoples In Australia, New Zealand, Canada And The United States: A Comprehensive Review, Shaouli Shahid, Emma V. Taylor, Shelley Cheetham, John A. Woods, Samar M. Aoun, Sandra C. Thompson

Health Sciences Papers and Journal Articles

Background: Indigenous peoples in developed countries have reduced life expectancies, particularly from chronic diseases. The lack of access to and take up of palliative care services of Indigenous peoples is an ongoing concern.

Objectives: To examine and learn from published studies on provision of culturally safe palliative care service delivery to Indigenous people in Australia, New Zealand (NZ), Canada and the United States of America (USA); and to compare Indigenous peoples’ preferences, needs, opportunities and barriers to palliative care.

Methods: A comprehensive search of multiple databases was undertaken. Articles were included if they were published in English from 2000 onwards …


Time For Change: Fitness And Strength Can Be Improved And Sustained In Adolescents With Low Motor Competence, Beth Hands, Paola Chivers, Tegan Grace, Fleur Mcintyre Jan 2018

Time For Change: Fitness And Strength Can Be Improved And Sustained In Adolescents With Low Motor Competence, Beth Hands, Paola Chivers, Tegan Grace, Fleur Mcintyre

Health Sciences Papers and Journal Articles

Background: There are few exercise interventions focused on adolescents with low motor competence and most interventions are short with little follow up and engagement over time.

Methods and procedures: Fifty-eight adolescents with low motor competence (39 males, Mean Age=13.6, SD=1.4 years) attended an exercise clinic twice a week for each 13 week program. Two programs ran each year, and participants attended for as long as they felt progress was made or they turned 18 years of age. Performance on the Multistage Fitness Test (MSFT), Curl-ups, Grip Strength, 1RM Leg press and Chest Press, Vertical Jump and Standing Broad Jump (SBJ) …


Suboptimal Bone Status For Adolescents With Low Motor Competence And Developmental Coordination Disorder - It's Sex Specific, Paola Chivers, Timo Rantalainen, Fleur Mcintyre, Beth Hands, Benjamin Weeks, Belinda Beck, Nimphius Sophia, Nicolas Hart, Aris Siafarikas Jan 2018

Suboptimal Bone Status For Adolescents With Low Motor Competence And Developmental Coordination Disorder - It's Sex Specific, Paola Chivers, Timo Rantalainen, Fleur Mcintyre, Beth Hands, Benjamin Weeks, Belinda Beck, Nimphius Sophia, Nicolas Hart, Aris Siafarikas

Health Sciences Papers and Journal Articles

Background: Australian adolescents with low motor competence (LMC) have higher fracture rates and poorer bone health compared to European normative data, but currently no normative data exists for Australians.

Aims: To examine whether there were bone health differences in Australian adolescents with LMC or Developmental Coordination Disorder (DCD) when compared to typically developing age-matched Australian adolescents.

Methods and Procedures: Australian adolescents aged 12–18 years with LMC/DCD (n=39; male=27; female=12) and an Australian comparison sample (n=188; boys=101; girls= 87) undertook radial and tibial peripheral Quantitative Computed Tomography (pQCT) scans. Stress Strain Index (SSI (mm3)), Total Bone Area (TBA (mm2)), Muscle Density …


International Validation Of The Eortc Qlq-Prt20 Module For Assessment Of Quality Of Life Symptoms Relating To Radiation Proctitis: A Phase Iv Study, Georgia K.B Halkett, Charles Adam Wigley, Samar M. Aoun, Maurizio Portaluri, Francesco Tramacere, Lorenzo Livi, Beatrice Detti, Stefano Arcangeli, Jo-Asmund Lund, Are Kristensen, Nathalie Mcfadden, Arne Grun, Sean Bydder, Irina Sackerer, Elfriede Greimel, Nigel Spry, Eortc Quality Of Life Group Jan 2018

International Validation Of The Eortc Qlq-Prt20 Module For Assessment Of Quality Of Life Symptoms Relating To Radiation Proctitis: A Phase Iv Study, Georgia K.B Halkett, Charles Adam Wigley, Samar M. Aoun, Maurizio Portaluri, Francesco Tramacere, Lorenzo Livi, Beatrice Detti, Stefano Arcangeli, Jo-Asmund Lund, Are Kristensen, Nathalie Mcfadden, Arne Grun, Sean Bydder, Irina Sackerer, Elfriede Greimel, Nigel Spry, Eortc Quality Of Life Group

Health Sciences Papers and Journal Articles

Background: Although patients experience radiation proctitis post radiotherapy no internationally tested instruments exist to measure these symptoms. This Phase IV study tested the scale structure, reliability and validity and cross-cultural applicability of the EORTC proctitis module (QLQ-PRT23) in patients who were receiving pelvic radiotherapy.

Methods: Patients (n = 358) from six countries completed the EORTC QLQ-C30, QLQ-PRT23 and EORTC Quality of Life Group debriefing questions. Clinicians completed the EORTC Radiation Therapy Oncology Group scale. Questionnaires were completed at four time-points. The module’s scale structure was examined and validated using standard psychometric analysis techniques.

Results: Three items were dropped from the …


Mitochondria And Neuroprotection In Stroke: Cationic Arginine-Rich Peptides (Carps) As A Novel Class Of Mitochondria-Targeted Neuroprotective Therapeutics, Gabriella Macdougall, Ryan S. Anderton, Frank L. Mastaglia, Neville W. Knuckey, Bruno P. Meloni Jan 2018

Mitochondria And Neuroprotection In Stroke: Cationic Arginine-Rich Peptides (Carps) As A Novel Class Of Mitochondria-Targeted Neuroprotective Therapeutics, Gabriella Macdougall, Ryan S. Anderton, Frank L. Mastaglia, Neville W. Knuckey, Bruno P. Meloni

Health Sciences Papers and Journal Articles

Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available neuroprotective agent for stroke. As a central mediator of neurodamaging events in stroke, mitochondria are recognised as a critical neuroprotective target, and as such, provide a focus for developing mitochondrial-targeted therapeutics. In recent years, cationic arginine-rich peptides (CARPs) have been identified as a novel class of neuroprotective agent with several demonstrated mechanisms of action, including their ability to target mitochondria and exert positive effects on the organelle. …


Intraoperative Detection Of Blood Vessels With An Imaging Needle During Neurosurgery In Humans, Hari Ramakonar, Bryden C. Quirk, Rodney W. Kirk, Jiawen Li, Angela Jacques, Christopher R.P Lind, Robert A. Mclaughlin Jan 2018

Intraoperative Detection Of Blood Vessels With An Imaging Needle During Neurosurgery In Humans, Hari Ramakonar, Bryden C. Quirk, Rodney W. Kirk, Jiawen Li, Angela Jacques, Christopher R.P Lind, Robert A. Mclaughlin

Health Sciences Papers and Journal Articles

Intracranial hemorrhage can be a devastating complication associated with needle biopsies of the brain. Hemorrhage can occur to vessels located adjacent to the biopsy needle as tissue is aspirated into the needle and removed. No intraoperative technology exists to reliably identify blood vessels that are at risk of damage. To address this problem, we developed an “imaging needle” that can visualize nearby blood vessels in real time. The imaging needle contains a miniaturized optical coherence tomography probe that allows differentiation of blood flow and tissue. In 11 patients, we were able to intraoperatively detect blood vessels (diameter, >500 μm) with …


Poly-Arginine R18 And R18d (D-Enantiomer) Peptides Reduce Infarct Volume And Improves Behavioural Outcomes Following Perinatal Hypoxic-Ischaemic Encephalopathy In The P7 Rat, Adam B. Edwards, Jane L. Cross, Ryan S. Anderton, Neville W. Knuckey, Bruno P. Meloni Jan 2018

Poly-Arginine R18 And R18d (D-Enantiomer) Peptides Reduce Infarct Volume And Improves Behavioural Outcomes Following Perinatal Hypoxic-Ischaemic Encephalopathy In The P7 Rat, Adam B. Edwards, Jane L. Cross, Ryan S. Anderton, Neville W. Knuckey, Bruno P. Meloni

Health Sciences Papers and Journal Articles

We examined the neuroprotective efficacy of the poly-arginine peptide R18 and its D-enantiomer R18D in a perinatal hypoxic-ischaemic (HI) model in P7 Sprague-Dawley rats. R18 and R18D peptides were administered intraperitoneally at doses of 30, 100, 300 or 1000 nmol/kg immediately after HI (8% O2/92%N2 for 2.5 h). The previously characterised neuroprotective JNKI-1-TATD peptide at a dose of 1000 nmol/kg was used as a control. Infarct volume and behavioural outcomes were measured 48 h after HI. For the R18 and R18D doses examined, total infarct volume was reduced by 25.93% to 43.80% (P = 0.038 to < 0.001). By comparison, the JNKI-1-TATD reduced lesion volume by 25.27% (P = 0.073). Moreover, R18 and R18D treatment resulted in significant improvements in behavioural outcomes, while with JNKI-1-TATD there was a trend towards improvement. As an insight into the likely mechanism underlying the effects of R18, R18D and JNKI-1-TATD, the peptides were added to cortical neuronal cultures exposed to glutamic acid excitotoxicity, resulting in up to 89, 100 and 71% neuroprotection, respectively, and a dose dependent inhibition of neuronal calcium influx. The study further confirms the neuroprotective properties of polyarginine peptides, and suggests a potential therapeutic role for R18 and R18D in the treatment of HIE.


Movement Economy In Soccer: Current Data And Limitations, Filippo Dolci, Nicolas H. Hart, Andrew Kilding, Paola Chivers, Benjamin Piggott, Tania Spiteri Jan 2018

Movement Economy In Soccer: Current Data And Limitations, Filippo Dolci, Nicolas H. Hart, Andrew Kilding, Paola Chivers, Benjamin Piggott, Tania Spiteri

Health Sciences Papers and Journal Articles

Soccer is an intermittent team-sport, where performance is determined by a myriad of psychological, technical, tactical, and physical factors. Among the physical factors, endurance appears to play a key role into counteracting the fatigue-related reduction in running performance observed during soccer matches. One physiological determinant of endurance is movement economy, which represents the aerobic energy cost to exercise at a given submaximal velocity. While the role of movement economy has been extensively examined in endurance athletes, it has received little attention in soccer players, but may be an important factor, given the prolonged demands of match play. For this reason, …


Netrin-1-Like-Immunoreactivity Co-Expresses With Dcc And Has A Differential Level In The Myenteric Cholinergic And Nitrergic Neurons Of The Adult Mouse Colon, Suh Youn Ko, John T. Price, Gregory L. Blatch, Kulmira Nurgali Jan 2018

Netrin-1-Like-Immunoreactivity Co-Expresses With Dcc And Has A Differential Level In The Myenteric Cholinergic And Nitrergic Neurons Of The Adult Mouse Colon, Suh Youn Ko, John T. Price, Gregory L. Blatch, Kulmira Nurgali

Health Sciences Papers and Journal Articles

Netrin-1 is a potent axonal and neuronal guidance cue in the developing nervous system. Netrin-1 functions are mediated by its receptors, such as deleted in colorectal cancer (DCC) present on axons and neurons. Localization of DCC and Netrin-1 on various types of enteric neurons and their role in the mature enteric nervous system is unknown. The results of our study revealed that almost all enteric neurons and processes express DCC and Netrin-1 in the adult mice. Netrin-1-like-immunoreactivity (IR) was detected in the cytoplasm of neurons with some showing strong or weak staining. The majority of Netrin-1-like-immunoreactive enteric neurons were choline …


An Assessment Of Effectiveness Of Participatory Video And Drama In Enhancing Learning Of “Climate-Smart” Push-Pull Technology: A Case Study Of Butere And Vihiga Farmers In Western Kenya, Wakesho George, Pittchar Jimmy, Midega Charles, Khan Zeyaur Jan 2018

An Assessment Of Effectiveness Of Participatory Video And Drama In Enhancing Learning Of “Climate-Smart” Push-Pull Technology: A Case Study Of Butere And Vihiga Farmers In Western Kenya, Wakesho George, Pittchar Jimmy, Midega Charles, Khan Zeyaur

All Peer-Reviewed Publications

This study assessed the effectiveness of participatory video and drama in enhancing learning of climate-smart pushpull technology in western Kenya. A total of 80 farmers who had no knowledge of push pull technology were exposed to participatory drama and video that had been developed by farmers who are adopting push pull technology. Validated questionnaires were used for data collection where sampled non push pull farmers were interviewed before and after exposure to push pull knowledge using participatory video and drama. Data obtained was analyzed using chi square at 0.05 confidence level set a priori and also presented using frequency tables, …