Digital Commons Network^™

Investigating Smoke Exposure And Chronic Obstructive Pulmonary Disease (Copd) With A Calibrated Agent Based Model (Abm) Of In Vitro Fibroblast Wound Healing., James A. Ratti

Theses and Dissertations

COPD is characterized by tissue inflammation and impaired remodeling that suggests fibroblast maintenance of structural homeostasis is dysregulated. Thus, we performed in vitro wound healing experiments on normal and diseased human lung fibroblasts and developed an ABM of fibroblasts closing a scratched monolayer using NetLogo to evaluate differences due to COPD or cigarette smoke condensate exposure. This ABM consists of a rule-set governing the healing response, accounting for cell migration, proliferation, death, activation and senescence rates; along with the effects of heterogeneous activation, phenotypic changes, serum deprivation and exposure to cigarette smoke condensate or bFGF. Simulations were performed to calibrate …

Consuming Digital Debris In The Plasticene, Stephen R. Parks

Theses and Dissertations

Claims of customization and control by socio-technical industries are altering the role of consumer and producer. These narratives are often misleading attempts to engage consumers with new forms of technology. By addressing capitalist intent, material, and the reproduction limits of 3-D printed objects’, I observe the aspirational promise of becoming a producer of my own belongings through new networks of production. I am interested in gaining a better understanding of the data consumed that perpetuates hyper-consumptive tendencies for new technological apparatuses. My role as a designer focuses on the resolution of not only the surface of the object through 3-D …

Quotations Like The Sharpest Claws, Johanna Robinson

Theses and Dissertations

Quotations like the Sharpest Claws describes a multimedia installation composed of paintings and sound that explores the theory of cognitive dissonance, a controversial psychological model that attempts to explain how we deal with inconsistency in incompatible beliefs. Imagination is given primacy as a source for truth-seeking and world-building. The uncanny and surreal are used as entry points into this topic.

The title is derived from a description of Eileen Myles’ poetry I once read in an anonymous review. Their writing was described as beyond poetry in a way that it could only be described as such when surrounded by “quotations …

Nitrogen Rich Porous Organic Frameworks: Proton Conduction Behavior Of 3d Benzimidazole And Azo-Linked Polymers, Michael J. Anhorn

Theses and Dissertations

Nitrogen-rich porous organic frameworks show great promise for use as acid-doped proton conducting membranes, due to their high porosity, excellent chemical and thermal stability, ease of synthesis, and high nitrogen content. Aided by very high surface area and pore volume, the material has the ability to adsorb high amounts of H₃PO₄ into its network, which creates a proton rich environment, capable of facile proton conduction. The morphology and chemical environment, doping behavior, and proton conduction of these materials were investigated. With such high acid-doping, ex-situ studies revealed that under anhydrous conditions, PA@BILP-16 (AC) produced a proton conductivity …

Work/Death, Of Each In Their Own, Micah H. Weber

Theses and Dissertations

Writings in support of my visual thesis, including some background, and bibliographic information: Oregon/Death/Animation/Vocation and the artist as an agent of potential.

Advances In Dual-Energy Computed Tomography Imaging Of Radiological Properties, Dong Han

Theses and Dissertations

Dual-energy computed tomography (DECT) has shown great potential in the reduction of uncertainties of proton ranges and low energy photon cross section estimation used in radiation therapy planning. The work presented herein investigated three contributions for advancing DECT applications. 1) A linear and separable two-parameter DECT, the basis vector model (BVM) was used to estimate proton stopping power. Compared to other nonlinear two-parameter models in the literature, the BVM model shows a comparable accuracy achieved for typical human tissues. This model outperforms other nonlinear models in estimations of linear attenuation coefficients. This is the first study to clearly illustrate the …

Black Lives Examined: Black Nonfiction And The Praxis Of Survival In The Post-Civil Rights Era, Ariel D. Lawrence

Theses and Dissertations

The subject of my thesis project is black nonfiction, namely the essay, memoir, and autobiography, written by black authors about and during the Post-Civil Rights Era. The central goals of this work are to briefly investigate the role of genre analysis within the various subsets of nonfiction and also to exemplify the ways that black writers have taken key genre models and evolved them. Secondly, I aim to understand the historical, political, and cultural contributions of the Post-Civil Rights Era, which I mark as hitting its stride in 1968. It is not my desire to create a definitive historical framework …

Rational Design Of Allosteric Modulators Of Hemoglobin As Dual Acting Antisickling Agents, Piyusha P. Pagare

Theses and Dissertations

Intracellular polymerization of deoxygenated sickle hemoglobin (Hb S) remains the principal cause of the pathophysiology associated with sickle cell disease (SCD). Naturally occurring and synthetic allosteric effectors of hemoglobin (AEH) have been investigated as potential therapeutic agents for the treatment of SCD. Several aromatic aldehydes, including vanillin, have been studied previously as AEHs for their antisickling activities. Specifically, these compounds form Schiff- base adduct with Hb to stabilize the oxygenated (R) state, increase Hb affinity for O2 and concomitantly prevent the hypoxia-induced primary pathophysiology of Hb S polymerization and RBC sickling, in turn, ameliorating several of the cascading secondary adverse …

Enact In Disappearance, Stephanie Demer

Theses and Dissertations

Enact in Disappearance excavates the unseen through the medium of photography in order to chart a new strategy for knowing and communing with a complicated world.

Rotating Supporting Hyperplanes And Snug Circumscribing Simplexes, Ghasemali Salmani Jajaei

Theses and Dissertations

This dissertation has two topics. The rst one is about rotating a supporting

hyperplane on the convex hull of a nite point set to arrive at one of its facets.

We present three procedures for these rotations in multiple dimensions. The rst

two procedures rotate a supporting hyperplane for the polytope starting at a lower

dimensional face until the support set is a facet. These two procedures keep current

points in the support set and accumulate new points after the rotations. The rst

procedure uses only algebraic operations. The second procedure uses LP. In the third

procedure we rotate a …

The Development Of Novel Inhibitors Of The Nlrp3 Inflammasome, Jacob W. Fulp

Theses and Dissertations

Inflammasomes are intracellular multimeric protein complexes that regulate inflammation by controlling the maturation of cytokines, interleukin-1β (IL-1β) and interleukin-18 (IL-18). Additionally, activation of these inflammasome complexes has been implicated in an inflammatory form of death known as proptosis. Of the known inflammasomes, the NOD-like receptor family pyrin domain containing 3 (NLPP3) inflammasome, is the most elucidated. Under physiological conditions, NLRP3-mediated inflammation promotes healing and the elimination of cellular debris and pathogens. However, the dysregulation of IL-1β, IL-18 and pyroptosis are instrumental in the development of multiple pathologies. Furthermore, studies suggest that the NLRP3 inflammasome mediates detrimental neuroinflammation and …

A Cape As Red As Blood And A Slipper As Pure As Gold: Vision And Visuality In The Costume Design Of Into The Woods, Hannah E. Chalman

Theses and Dissertations

This thesis explores the costume design for Theatre VCU’s 2018 production of Into the Woods. It outlines my concept for the design focusing on the origins of these archetypes. This concept is further expanded on by discussing Cinderella and the Witch characters and analyzing the choices within their costumes. This thesis also includes renderings, swatches, and photos.

The Player’S Journey: Ludology And Narratology In Modern Gaming, Angelica Fuchs

Theses and Dissertations

This thesis examines the evolution of gaming criticism (specifically ludology and narratology) and games as a medium of expression through the use of case studies. These case studies look at some of the core aspects of four major titles (The Last of Us, Horizon Zero Dawn, various BioWare games and Journey) and survey how these games work to effectively employ a narrative while maintaining an immersive, intuitive system for the player to interact with. Through these titles, the thesis suggests that in order to gain a full scope of a game’s intentions, studies should analyze more than …

Laminated Paint, Travis R. Austin

Theses and Dissertations

Though we may not perceive it, we are surrounded by material-in-flux. Inert materials degrade and the events that comprise our natural and social environments causally thread into a duration that unifies us in our incomprehension. Sounds reveal ever-present vibrations of the landscape: expressions of the flexuous ground on which we stand.

Untitled, Daliya Jokondo

Theses and Dissertations

My practice is concerned with the activation of fragmentation, concealment and evasiveness as practical tools for surviving (the danger of visibility when positioned in the margins) while moving or engaging with oppressive power structures. The aforementioned appear in my practice as complete forms of erasure, adornment and costuming, in addition to language play. My thesis’ concern is the desire to speak the autobiographical in relation to generational trauma. Herein lives the voices of three generations of survivors.

Escapism: Indulging In Daydreams, Tanruk Pairoj-Boriboon

Theses and Dissertations

A fantasy world, that exists only in our minds, provides us a place where we can mentally escape from everyday reality. Escapism, such as indulging in daydreams, allows us to experience comfort and makes us feel safe, eliminating feelings of insecurity and vulnerability.

This study aims to use playfulness and reverie as a tool to access and confront mental discomforts. Transforming disturbing situations into an experience of reverie; a correction of unsatisfying reality, by converting a solid component of the real world into a desirable infinite form will provide alternative viewpoints.

Throughout my work, this method has been employed to …

Assessing Research Productivity From An Institutional Effectiveness Perspective: How Universities Influence Faculty Research Productivity, Michael M. Rawls

Theses and Dissertations

Faculty research productivity studies typically focus on the scholarly performance of the individual researcher, although environmental and organizational conditions that are largely outside of the researcher’s control can significantly impact that performance. From an institutional effectiveness perspective, it is imperative for the higher education administrators and leaders who share the responsibility of managing and supporting their university’s research enterprise to understand how the institutional environment itself impacts the productivity of its research community. In this sequential mixed methods study, a quantitative framework was tested for assessing institutional effectiveness in research administration based on the assertion that this concept can be …

Structural And Functional Consequences Of Hiv-1 Viral Protein Tat And Morphine Co-Exposure At The Blood-Brain Barrier, Crystal R. Leibrand

Theses and Dissertations

According to UNAIDS 2016, over 37 million people worldwide were infected with human immunodeficiency virus (HIV) in 2016, with over 1.2 million people living with HIV in the United States. Of those, approximately one half will suffer from HIV-associated neurocognitive disorders (HAND), which is a spectrum of neurocognitive disorders ranging from asymptomatic neurocognitive impairment, to mild neurocognitive disorder, to HIV-associated dementia. While combination antiretroviral therapy (cART) has decreased the incidence of the most severe forms of HAND in patients with HIV, milder forms of HAND still persist. These defects can include decreased motor skills, cognitive abilities, memory, and attention. While …

Development And Validation Of A Semi-Physiological Pharmacokinetic (Pbpk) Model To Predict Systemic And Pulmonary Exposures After Intravenous, Oral Administration And Pulmonary Inhalation Of Selected Drugs, Budesonide, Tobramycin And Ciprofloxacin, In Humans, Bishoy Hanna

Theses and Dissertations

Using a semi-PBPK modeling/quantitative meta-analysis approach, this project investigated what factors affect pulmonary and systemic exposures of Budesonide (BUD), Tobramycin (TOB), and Ciprofloxacin (CIP) after inhalation:

Three structurally different pulmonary disposition models were developed for each drug, including pulmonary absorption (all three), excretion (TOB and CIP) and sequestration (TOB) in a peripheral and central lung compartment. Systemic disposition parameters were estimated using available human mean plasma (c_p(t)) and sputum (c_s(t)) concentration profiles after IV administration, and GI absorption parameters were estimated from these profiles after oral administration. Pulmonary disposition parameters were estimated from c_p(t) …

Path, Evan Galbicka

Theses and Dissertations

Path is a collaborative system that developed over the course of five months of studio activity and continued through the duration of the exhibition. The system’s main collaborators were a land snail native to eastern North America (Neohelix albolabris), myself, and a digital cellular automaton. These prime agents interwove processes and exchanges between one another into a complex network of folded fractal feedback loops. Cyclic processes produced artifacts and infrastructures to support communication between the components and agents of Path. As a whole, Path spoke to the possibilities for interspecies, cyber-physical, and ecological collaboration to create an …

A Third Place: For Children(5–7) To Play And Learn, Yuqi Ye

Theses and Dissertations

The motivation for this project follows the untimely death of an Asian student last year. Crime rates, especially with regard to young children, are tough social problems happening in a lot of countries. Education and structured play are a key solution related to decreasing these crime rates. In today's educational systems, preschool education should involve family and community, foster mutual cooperation, and provide the best environment for a child's growth to promote their potential development.

Contesting The Commemorative Narrative: Planning For Richmond’S Cultural Landscape, Hannah M. Cameron

Theses and Dissertations

Abstract: New Orleans, Baltimore, and Charlottesville are reevaluating the presence of Confederate statues in their built environment. Known as the Capital of the Confederacy, Richmond’s cultural landscape is visible through the connection of two historical spaces, Monument Avenue and Shockoe Bottom. Both serve as a powerful case study for how the commemorative narrative of these spaces is contested today and how barriers that exist influence urban planning processes and outcomes.

The Building Breathes Together, Mckeever Donovan

Theses and Dissertations

The Building Breathes Together presents a realm of speculative, industrial habitation and alchemical production. In my instillation, I look to raise questions surrounding romantic notions of production and utility. The work introduces a surreal and haunted space of decomposition and regeneration.

The Break, Ian Gerson

Theses and Dissertations

The Break is a personal investigation into problems and possibilities of representing my specific transgender identity.

Trans as a tactic to speak about a state of forever becoming, forever in between, outside of and in opposition to dominant social norms of being.

Trans as a model for a different way of viewing and being in the world.

Can we form a different kind of horizontal shared power though a collective refusal to play into existing structures from which we have been excluded? What are the potentials for modeling other ways of being, other ways of (dis)engaging, other ways to be …

Nuclear Rupture In Progeria Expressing Cells, Kranthidhar Bathula

Theses and Dissertations

Cells regularly take on various types of force in the body. They have structures that are able to mediate, transfer and respond to the forces. A mutation in force regulating proteins such as lamin in the nucleus or the KASH domain which connects the nucleus to the cytoskeleton of the cell can cause catastrophic events to occur. The aims of this study were to better understand the response of the nucleus when structural proteins are mutated or are not present while under force. Progeria, a rare disease where an additional farnesyl group is attached to lamin was used in this …

You Build Like A Girl, Sara Hackett

Theses and Dissertations

The thesis explored creating a space for young women to gain confidence and experience in the built environment under the guidance of female mentors. Teaching not only tool skills, but also the fundamentals of design thinking and problem solving to encourage bold decisions and lead to career decisions that expand the skilled workforce candidate pool.

Enhancing Adherence To Prescribed Opioids Using A Mobile-Base Application: A Pilot Study Of Feasibility In Chronic Non-Cancer Pain, Daniel M. Sop

Theses and Dissertations

In this study we present feasibility of a mobile monitoring and reporting system that would provide an accurate unbiased screening tool to systematically analyze opioid adherence in Sickle cell disease patients. In addition, the software simultaneously measures pain. The Mobile Applications Rating Scale: a new and validated tool for assessing the quality of health mobile apps for engagement, functionality, aesthetics, information quality, subjective quality, relevance and overall impact was administered post usage to evaluate the application.

A total of 28 patients were recruited to review and test the software at one sitting. The majority of the population found the application …

Designing School Community: Changing Inner-City Middle School Culture Through Interiors, Rachel A. Ramey

Theses and Dissertations

While the knowledge of disrepair in inner-city schools is fairly common, the impact that school facilities are having on students and faculty is not as widely known. More recently, the closing of inner city schools has greatly increased across the United States; Reduction in public school enrollment from 2006-2013: Detroit -63%, Cleveland -32%, Indianapolis -27%, D.C. -23%, L.A. -23%,etc. (Journey For Justice Alliance,2014).

Due to budget cuts, threat of school closings from poor facility conditions, large class size, and pressure to raise test scores, inner city schools struggle to keep teachers (Journey For Justice Alliance,2014). Poor teacher retention along with …

Psychick Order, Corissa Duffey

Theses and Dissertations

Preserving Psychick Order is an investigation into the subliminal, of a body processing trauma and transition. I explore how my mind and body filter memory, fear, and the impact of the past into the present. Since childhood, making dolls has been a way for me to express complex feelings, especially as they relate to dynamics between biological and found family. By tenderly modeling dolls after my own transforming physical features and mental processes, I make connections between the effects of my mind on my body and vice versa. I like to describe the resulting forms as queer monsters trying to …

Engineering Surface Properties To Modulate Inflammation And Stem Cell Recruitment Through Macrophage Activation, Kelly M. Hotchkiss

Theses and Dissertations

Biomaterials are becoming the most commonly used therapeutic method for treatment of lost or damaged tissue in the body. Metallic materials are chosen for high strength orthopaedic and dental applications. Titanium (Ti) implants are highly successful in young, healthy patients with the ability to fully integrate to surrounding tissue. However the main population requiring these corrective treatments will not be healthy or young, therefore further research into material modifications have been started to improve outcomes in compromised patients. The body’s immune system will generate a response to any implanted material, and control the final outcome. Among the first and most …