Digital Commons Network^™

Role Of Hox Genes In Stem Cell Differentiation And Cancer., Seema Bhatlekar, Jeremy Z Fields, Bruce M. Boman

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

HOX genes encode an evolutionarily conserved set of transcription factors that control how the phenotype of an organism becomes organized during development based on its genetic makeup. For example, in bilaterian-type animals, HOX genes are organized in gene clusters that encode anatomic segment identity, that is, whether the embryo will form with bilateral symmetry with a head (anterior), tail (posterior), back (dorsal), and belly (ventral). Although HOX genes are known to regulate stem cell (SC) differentiation and HOX genes are dysregulated in cancer, the mechanisms by which dysregulation of HOX genes in SCs causes cancer development is not fully understood. …

Anesthesia Considerations For Intraoperative Neurophysiological Monitoring, Kimberly A. Moon

Nursing Capstones

No abstract provided.

Brief For Amicus Curiae - Rice University And Other Institutions, Rhode Island School Of Design

Advocacy | Amicus Briefs + Comments

No abstract provided.

Tio2 Assisted Photodegradation For Low Substrate Concentrations And Transition Metal Electron Scavengers, Hassan A. Alsaud, Ahmed E. Abibat, Roger Painter, Lonnie Sharpe, Samuel Keith Hargrove

Mechanical and Manufacturing Engineering Faculty Research

Some contaminants of emerging concern (CECs) are known to survive conventional wastewater treatment, which introduces them back to the environment, allowing them to potentially cycle into drinking water. This is especially concerning because of the inherent ability of some CECs to induce physiological effects in humans at very low doses. Advanced oxidation processes (AOPs) such as TiO2-based photocatalysis are of great interest for addressing CECs in aqueous environments. Natural water resources often contain dissolved metal cation concentrations in excess of targeted CEC concentrations. These cations may significantly adversely impact the degradation of CECs by scavenging TiO2 surface generated electrons. Consequently, …

Perspectives In Melanoma: Meeting Report From The Melanoma Bridge (30 November-2 December, 2017, Naples, Italy)., Paolo A Ascierto, Igor Puzanov, Sanjiv S Agarwala, Carlo Bifulco, Gerardo Botti, Corrado Caracò, Gennaro Ciliberto, Michael A Davies, Reinhard Dummer, Soldano Ferrone, Thomas F Gajewski, Claus Garbe, Jason J Luke, Francesco M Marincola, Giuseppe Masucci, Janice M Mehnert, Nicola Mozzillo, Giuseppe Palmieri, Michael A Postow, Stephen P Schoenberger, Ena Wang, Magdalena Thurin

Articles, Abstracts, and Reports

Metastatic melanoma represents a challenging clinical situation and, until relatively recently, there was an absence of effective treatment options. However, in 2011, the advanced melanoma treatment landscape was revolutionised with the approval of the anti-cytotoxic T-lymphocyte-associated protein-4 checkpoint inhibitor ipilimumab and the selective BRAF kinase inhibitor vemurafenib, both of which significantly improved overall survival. Since then, availability of new immunotherapies, especially the anti-programmed death-1 checkpoint inhibitors, as well as other targeted therapies, have further improved outcomes for patients with advanced melanoma. Seven years on from the first approval of these novel therapies, evidence for the use of various immune-based and …

Heart Development, Coronary Vascularization And Ventricular Maturation In A Giant Danio (Devario Malabaricus), Pascal J. Lafontant, Olubusola Shifatu, Sarah Glasshagel-Chilson, Purva Patel, Wendy Tomamichel, Clay Higginbotham, Paula K. Evans, Hannah M. Nelson

Biology Faculty publications

Giant danios (genus Devario), like zebrafish, are teleosts belonging to the danioninae subfamily of cyprinids. Adult giant danios are used in a variety of investigations aimed at understanding cellular and physiological processes, including heart regeneration. Despite their importance, little is known about development and growth in giant danios, or their cardiac and coronary vessels development. To address this scarcity of knowledge, we performed a systematic study of a giant danio (Devario malabaricus), focusing on its cardiac development, from the segmentation period to ten months post-fertilization. Using light and scanning electron microscopy, we documented that its cardiovascular development and maturation proceed …

Paired Dissolved And Particulate Phase Cu Isotope Distributions In The South Atlantic, Susan H. Little, Corey Archer, Angela Milne, Christian Schlosser, Eric P. Achterberg, Maeve C. Lohan, Derek Vance

School of Geography, Earth and Environmental Sciences

© 2018 The Authors Copper (Cu) is both an essential micronutrient and toxic to photosynthesizing microorganisms at low concentrations. Its dissolved vertical distribution in the oceans is unusual, being neither a nutrient-type nor scavenged-type element. This distribution is attributed to biological uptake in the surface ocean with remineralisation at depth, combined with strong organic complexation by dissolved ligands, scavenging onto particles, and benthic sedimentary input. We present coupled dissolved and particulate phase Cu isotope data along the UK-GEOTRACES South Atlantic section, alongside higher resolution dissolved and particulate phase Cu concentration measurements. Our dissolved phase isotope data contribute to an emerging …

How Much Privacy Do We Have Today? A Study Of The Life Of Marc Mezvinsky, Miguel Mares, Salomon Gilles, Brian D. Gobran, Dan Engels

SMU Data Science Review

In this paper, we present a case study evaluating the level of information available about an individual through public, Internet-accessible sources. Privacy is a basic tenet of democratic society, but technological advances have made access to information and the identification of individuals much easier through Internet-accessible databases and information stores. To determine the potential level of privacy available to an individual in today’s interconnected world, we sought to develop a detailed history of Marc Mezvinsky, a semi-public figure, husband of Chelsea Clinton, and son of two former members of the United States House of Representatives. By utilizing only publicly and …

Predictions Generated From A Simulation Engine For Gene Expression Micro-Arrays For Use In Research Laboratories, Gopinath R. Mavankal, John Blevins, Dominique Edwards, Monnie Mcgee, Andrew Hardin

SMU Data Science Review

In this paper we introduce the technical components, the biology and data science involved in the use of microarray technology in biological and clinical research. We discuss how laborious experimental protocols involved in obtaining this data used in laboratories could benefit from using simulations of the data. We discuss the approach used in the simulation engine from [7]. We use this simulation engine to generate a prediction tool in Power BI, a Microsoft, business intelligence tool for analytics and data visualization [22]. This tool could be used in any laboratory using micro-arrays to improve experimental design by comparing how predicted …

Evaluating Feasibility Of Blockchain Application For Dscsa Compliance, Tracie Scott, Armand L. Post, Johnny Quick, Sohail Rafiqi

SMU Data Science Review

Abstract. We evaluated the feasibility of using a blockchain technology to create a traceability solution for pharmaceutical drugs that would promote compliance with recent legislation. Counterfeit and other illegitimate pharmaceutical drugs threaten patient safety, drug efficacy, and patient trust. The purpose of the Drug Supply Chain Security Act (DSCSA) is to greatly reduce distribution of illegitimate drugs by requiring all pharmaceuticals to be serialized and traceable from the manufacturer through the supply chain to the dispenser. A software application to serialize and track pharmaceuticals must overcome numerous obstacles. In particular, the solution must provide a high degree of trust while …

On The Bravery And Courage Of Heroes: Considering Gender, Elaine L. Kinsella, Timothy D. Ritchie, Eric R. Igou

Heroism Science

Heroes are frequently described as both brave and courageous. Each adjective is often used interchangeably in public and academic discourse, despite historical and philosophical differences in their meaning. While research about heroes and heroism is burgeoning, little work has yet to provide a detailed analysis of specific hero features; indeed, there is a need for greater precision in our terminology and conceptual analyses of heroism. In the present article, we focus on two features of heroism, bravery and courage, and critically parse these terms and the pervasive gender stereotypes that are associated with each. We aim to spark critical discussions …

Biomedical Engineering - An Art Or A Science?, Sowmya Anjur

Faculty Publications & Research

Students discussed recent advances in technology and classified them as belonging to science or engineering. Students were introduced to the human heart and its mechanics, after which they brainstormed in groups to build their own life-sized heart models, choosing from the materials provided and demonstrated their working models to each other. Students were encouraged to create "diseases" in their heart models and explain how they would correlate this to "real'life" experiences. Students were also introduced to my newest project, arduino heart rate monitors and asked to suggest creative projects that they could work on in the near future.

This Is How We Did It: A Grounded Theory Approach Of Black Male Success, Aaron Smith

Graduate Dissertations and Theses

For decades, literature has described success for Black males as a hard-to-obtain phenomenon due to the nearly insurmountable hardships they face. Although this previous negative narrative has positively shifted within the last 15 years, there are still insignificant amounts of research on how to obtain Black male life success. This study sought to discover how 14 Black males in Central Virginia achieved life success. In this study, life success for Black males was defined and explored utilizing the psychological construct of well-being. This grounded theory study identified a framework for Black male life success which included a definition for life …

Narcolepsy Or Gelineau Syndrome, Tammy Rainey

Nursing Student Class Projects (Formerly MSN)

According to the U.S. Library of Medicine (2018), 1 in 2000 individuals in the United States and Western Europe are affected by narcolepsy, or Gelineau syndrome. Those with mild symptoms may not be diagnosed, and worse yet, those seeking medical attention may be misdiagnosed, especially in children and adolescents. Further research of the disease revealed misdiagnosis is a common theme with narcolepsy. Often, individuals are diagnosed with emotional or psychiatric disorders and prescribed inappropriate medications. “Lack of clinical awareness about different presentations in children and adolescents often leads to misdiagnosis of narcolepsy as schizophrenia, epilepsy, and other neurological disorders” often …

Mcnair Scholars Summer Research Symposium [Program] 2018, Mcnair Scholars Program (University Of Northern Iowa).

McNair Scholars Summer Symposium Programs

No abstract provided.

Etidronate Prevents, But Does Not Reverse, Ectopic Mineralization In A Mouse Model Of Pseudoxanthoma Elasticum (, Qiaoli Li, Joshua Kingman, John P Sundberg, Michael A Levine, Jouni Uitto

Faculty Research 2018

Pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI) are heritable disorders manifesting with ectopic tissue mineralization. Most cases of PXE and some cases of GACI are caused by mutations in the ABCC6 gene, resulting in reduced plasma pyrophosphate (PPi) levels. There is no effective treatment for these disorders. It has been suggested that administration of bisphosphonates, stable and non-hydrolyzable PPi analogs, could counteract ectopic mineralization in these disorders. In this study we tested the potential efficacy of etidronate, a first generation bisphosphonate, on ectopic mineralization in the muzzle skin of Abcc6^-/- mice, a model of PXE. The …

Plant Biology Chemistry Researchers Present At Cell Wall Conference, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Strive To Realize Modernization Of Concept, Equipment, Technology, And Management Of Modern Marince Ranching Development, Yang Hongsheng, Yang Xinyuan, Lin Chenggang, Zhang Libin, Xu Qiang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Modern marine ranching should be given high priority for environmental protection and marine fishery health in coastal areas. The approach of Chinese marine ranching is continuously developing. It was transferred from artificial reef construction and stock enhancement to the improvement of the marine environment and conservation of fishery resources. Chinese marine ranching is vigorously developing, 64 national marine ranching demonstration areas have been completed. At the same time, how to modernize the development of marine ranching is still an important problem to be solved. This paper discusses the construction system of modern marine ranching from four aspects:concept modernization, equipment modernization, …

No Security Through Obscurity: Changing Circumvention Law To Protect Our Democracy Against Cyberattacks, Andrew Moshirnia

Brooklyn Law Review

Cybersecurity is increasingly vital in a climate of unprecedented digital assaults against liberal democracy. Russian hackers have launched destabilizing cyberattacks targeting the United States’ energy grid, voting machines, and political campaigns. America's existing inadequate cyber defenses operate according to a simple assumption: hide the computer code that powers critical infrastructure so that America's enemies cannot exploit undiscovered weaknesses. Indeed, the intellectual property regime relies entirely on this belief, protecting those who own the rights in computer code by punishing those who might access and copy that code. This “security through obscurity” approach has failed. Rightsholders, on their own, cannot develop …

Exploring Targets Of Transcription Factors In Cancer Signaling Pathways, Tham Hong Hoang

Doctoral Dissertations

Recent studies have suggested a key role of activities related to target genes of transcription factors (TFs) in cancer signaling pathways. Molecular pathway curation includes mostly upstream signals which are well-established in the literature, but the activities that are downstream of TFs are not well understood. The purpose of this thesis is to design a computational method for exploring TF target genes in a given molecular pathway. We then use this data to stratify patients and relate TF activity to patient survival.

Transcriptome data can provide a detailed readout of events taking place within a cancer, but new computational tools …

Erepo-Orp: Exploring The Opportunity Space To Combat Orphan Diseases With Existing Drugs, Michal Brylinski, Misagh Naderi, Rajiv Gandhi Govindaraj, Jeffrey Lemoine

Faculty Publications

© 2017 About 7000 rare, or orphan, diseases affect more than 350 million people worldwide. Although these conditions collectively pose significant health care problems, drug companies seldom develop drugs for orphan diseases due to extremely limited individual markets. Consequently, developing new treatments for often life-threatening orphan diseases is primarily contingent on financial incentives from governments, special research grants, and private philanthropy. Computer-aided drug repositioning is a cheaper and faster alternative to traditional drug discovery offering a promising venue for orphan drug research. Here, we present eRepo-ORP, a comprehensive resource constructed by a large-scale repositioning of existing drugs to orphan diseases …

Dietary Polyphenols And Periodontitis—A Mini-Review Of Literature, Arpita Basu, Emily Masek, Jeffrey L. Ebersole

Kinesiology and Nutrition Sciences Faculty Research

Periodontitis, which is a chronic infection and disease of the periodontium, is a significant global health burden and is linked to other chronic health conditions such as diabetes and cardiovascular diseases. Dietary polyphenols present in a wide variety of plant-based foods, herbs, and botanicals have been shown to exert antimicrobial, anti-inflammatory, and reduced osteoclast and alveolar bone loss activities in animal models of periodontitis. Polyphenol-containing beverages and foods especially green tea and its active catechin epigallocatechin-3-gallate, cranberries, pomegranates, and fruit and vegetable extracts have reported bacteriostatic/bactericidal activity against microbial species such as P. gingivalis and shown total bacterial burden in …

Fitness Consequences Of Interspecific Nesting Associations Among Cavity-Nesting Birds, James C. Mouton, Thomas E. Martin

Aspen Bibliography

Interspecific aggregations of prey may provide benefits by mitigating predation risk, but they can also create costs if they increase competition for resources or are more easily detectable by predators. Variation in predation risk and resource availability may influence the occurrence and fitness effects of aggregating in nature. Yet tests of such possibilities are lacking. Cavity-nesting birds provide an interesting test case. They compete aggressively for resources and experience low nest predation rates, which might predict dispersion, but across 19 years of study we found that they commonly aggregate by sharing nest trees. Tree sharing was more common when aspen …

Yeast: The Gateway To Redefining And Improving Biology Labs, Connor Loomis

Biology Summer Fellows

Building off of collegiate research performed during the summer of 2018, this lesson plan outlines a lab for secondary students using yeast. Yeast is an affordable and convenient organism to introduce to secondary education, and students can learn a lot about biology through it. Essentially, the goal of the lab is for students to explore the effects of certain substances on the growth of yeast. While content is emphasized, this lesson plan also looks to build students’ understanding of science in general as well as proper laboratory skills and technique. In addition, it pushes students in their thinking as they …

Resolving The Anomaly Of Lomatium Anomalum: Discovery Of A New Species In Southwestern Idaho (U.S.A.), Lomatium Andrusianum (Apiaceae), Mckayla Stevens, Donald H. Mansfield, James F. Smith, Mary Ann E. Feist

Biology Faculty Publications and Presentations

Apparent polyphyly within the unresolved clade of Lomatium (Apiaceae) containing L. triternatum, L. anomalum, L. thompsonii, and L. packardiae suggests conflict among current taxonomic classification schemes. To recover this clade and more clearly define species boundaries, we examined populations of L. anomalum from three geographic regions in Idaho and adjacent Oregon. Using phylogenetic, morphological, and ecological data, we conclude that the L. anomalum complex currently circumscribes multiple species. Phylogenetic analysis of the nuclear ribosomal ITS and ETS, and cpDNA rpl32-trnLUAG, rps-16 intron, trnD-trnT, ndhA intron, and psbA-trnH recovered populations from the Boise foothills as a distinct, monophyletic clade. Principal …

In Silico Prediction Of Novel Residues Involved In Amyloid Primary Nucleation Of Human I56t And D67h Lysozyme, Jeddidiah W.D. Griffin, Patrick C. Bradshaw

ETSU Faculty Works

Background: Amyloidogenic proteins are most often associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, but there are more than two dozen human proteins known to form amyloid fibrils associated with disease. Lysozyme is an antimicrobial protein that is used as a general model to study amyloid fibril formation. Studies aimed at elucidating the process of amyloid formation of lysozyme tend to focus on partial unfolding of the native state due to the relative instability of mutant amyloidogenic variants. While this is well supported, the data presented here suggest the native structure of the variants may …

Blue Light Induces A Neuroprotective Open Access Gene Expression Program In Drosophila Photoreceptors, Hana Hall, Jingqun Ma, Sudhanshu Shekhar, Walter D. Leon-Salas, Vikki M. Weake

Department of Biochemistry Faculty Publications

Background: Light exposure induces oxidative stress, which contributes to ocular diseases of aging. Blue light provides a model for light‑induced oxidative stress, lipid peroxidation and retinal degeneration in Drosophila melanogaster. In contrast to mature adults, which undergo retinal degeneration when exposed to prolonged blue light, newly‑eclosed fies are resistant to blue light‑induced retinal degeneration. Here, we sought to characterize the gene expression programs induced by blue light in fies of diferent ages to identify neuroprotective pathways utilized by photoreceptors to cope with light‑induced oxidative stress.

Results: To identify gene expression changes induced by blue light exposure, we profled the nuclear …

Lindenwood Digest, July 20, 2018, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been an employee newsletter since 2009.

Novel Applications Of Biolayer Interferometry To Investigate Molecular Interactions, Mareena M. Pitts

Master of Science in Integrative Biology Theses

In this study, BLI is used to explore various molecular interactions to demonstrate molecular binding and to provide quantitative characterization of binding kinetics and affinities of phage-protein and DNA-protein interactions. The results of this study demonstrate novel use of biolayer interferometry to immobilize whole Sf6 bacteriophage onto the biosensor to measure the binding to its outer membrane host receptor protein OmpA. The use of BLI also demonstrates the technology as a probe to predict and verify binding interactions at the molecular level to assign the role of protein function in both Vibrio fischeri and Pseudomonas aeruginosa. Each aim of this …

Understanding The American Subaltern: An Exploration Of Complex Literary Characters Through Socio-Cultural Lenses, Sophie Gioffre

English and Creative Writing Summer Fellows

This project involves the analysis of three novels — Stephen Crane’s Maggie: A Girl of the Streets, Ann Petry’s The Street, and Toni Morrison’s Sula — featuring main characters who are forced to navigate realistic socio-economic environments rooted in racist, sexist, and classist systems of oppression in the United States of America. Through the process of completing close-readings of the novels, conducting extensive secondary research on historical contexts, and examining other scholarly criticisms and interpretations of these novels, I develop new insights into the main characters’ plights. To transfer this conceptual understanding into a more personal and empathetic …