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Sh3bp2 Gain-Of-Function Mutation Exacerbates Apical Periodontitis In Cherubism Mice, Homan Javaheri

Master's Theses

Cherubism (CBM) is characterized by multiple fibro-osseous lesions in jawbones and caused by mutations in the SH3-domain binding protein 2 (SH3BP2). CBM patients also suffer from dental abnormalities. Biochemical analyses showed that mutations in CBM lead to SH3BP2 gain-of-function because mutant SH3BP2 is protected from tankyrase-mediated proteasomal degradation. A knock-in (KI) mouse model expressing a CBM substitution mutation (P416R) in Sh3bp2 has been generated. Homozygous mice (Sh3bp2^KI/KI) show increased systemic inflammation and osteopenia phenotype with high serum TNF-α level, increased numbers of macrophages and enhanced osteoclastogenesis. Heterozygous mice (Sh3bp2^+/KI) exhibit intermediate phenotype …

Climate-Informed Environmental Inflows To Revive A Drying Lake Facing Meteorological And Anthropogenic Droughts, Aneseh Alborzi, Ali Mirchi, Hamed Moftakhari, Iman Mallakpour, Sara Alian, Ali Nazemi, Elmira Hassanzadeh, Omid Mazdiyasni, Samaneh Ashraf, Kaveh Madani, Hamid Norouzi, Marzi Azarderakhsh, Ali Mehran, Mojtaba Sadegh, Andrea Castelletti, Amir Aghakouchak

Publications and Research

The rapid shrinkage of Lake Urmia, one of the world's largest saline lakes located in northwestern Iran, is a tragic wake-up call to revisit the principles of water resources management based on the socio-economic and environmental dimensions of sustainable development. The overarching goal of this paper is to set a framework for deriving dynamic, climate-informed environmental inflows for drying lakes considering both meteorological/climatic and anthropogenic conditions. We report on the compounding effects of meteorological drought and unsustainable water resource management that contributed to Lake Urmia's contemporary environmental catastrophe. Using rich datasets of hydrologic attributes, water demands and withdrawals, as well …

Uab Doctoral Hooding, Commencement Ceremonies Are Aug. 10-11, Staff

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No abstract provided.

Creating A Participatory Arts-Based Online Focus Group: Highlighting The Transition From Docmama To Motherscholar, Anna Cohenmiller

The Qualitative Report

Using Facebook to create a participatory, arts-based online focus group, this study had two primary purposes: (1) to examine how mothers in academia present themselves as they transition from doctoral student mother (“DocMama”) to full time position as motherscholars and (2) to explore the use of a participatory, arts-based online focus group on Facebook to facilitate participant description of experiences and feelings. This study adds both to the research on online research by emphasizing a collaborative nature and art to share experiences, and also to the research about motherscholars, examining the oft overlooked transition from doctoral program to academic career …

Ocean Acidification Drives Community Shifts Towards Simplified Non-Calcified Habitats In A Subtropical-Temperate Transition Zone, Sylvain Agostini, Ben P. Harvey, Shigeki Wada, Koetsu Kon, Marco Milazzo, Kazuo Inaba, Jason M. Hall-Spencer

School of Biological and Marine Sciences

No abstract provided.

Old And Recent Processes In A Warm And Humid Desert Hypogene Cave: ‘A’Rak Na‘Asane, Israel, Amos Frumkin, Shlomi Aharon, Uri Davidovich, Boaz Langford, Yoav Negev, Micka Ullman, Anton Vaks, Shemesh Ya‘Aran, Boaz Zissu

International Journal of Speleology

Recent environmental processes are studied in ʻA’rak Naʻasane Cave at the northern Judean Desert, Israel. The outer zone of the cave is heavily influenced by the outside environment through a large entrance, facilitating entry of air flow, fauna and humans, with minor cave-forming modifications. Conversely, the inner cave sustains humid and warm conditions, favoring modifications by condensation corrosion of convective air flow, associated with deposition of popcorn speleothems at the lower parts of dissolution pockets. The warm humid air of the inner cave may be associated with an underlying thermal water table. Active condensation corrosion is decreasing, possibly because of …

An Analysis Of Peer-Assessment In Chinese As A Second Language Classroom Presentation, Lu Lu

Chinese Language Teaching Methodology and Technology

This study aims to 1) investigate the difference in the scorings between PA and teacher assessment in oral presentation, and 2) explore student’s attitude about PA through both quantitative and qualitative approaches. A class of 12 students in an upper-intermediate Chinese language class adopted PA by using Poll Everywhere during an academic year. The results indicate that intermediate-high Chinese learners and instructor interpret the criteria differently in Pronunciation, Fluency, Clarity, and Accuracy, but agree with the scores on Content and Delivery. Most students are positive that PA is a useful method to help them actively participate in class discussions and …

The Usefulness Of Gps Telemetry To Study Wolf Circadian And Social Activity, Samuel B. Merrill, L. David Mech

United States Geological Survey, Northern Prairie Wildlife Research Center: Publications

This study describes circadian and social movement patterns of 9 wolves and illustrates capabilities and limitations of Global Positioning System (GPS) telemetry for analysis of animal activity patterns. Wolves were studied at the Camp Ripley National Guard Training Site in Little Falls, Minnesota, and were captured via helicopter net-gunning. All study wolves showed nocturnal movement patterns regardless of time of year. One wolf's movement pattern switched to diurnal when he conducted an extraterritorial foray from his natal territory. All data sets with GPS intervals <1 hour (n=4) showed crepuscular movement peaks. We identified patterns of den visitation and attendance, estimated minimum distances traveled and minimum rates of movement, and observed that GPS location intervals may affect perceived rates of wolf travel. Global Positioning System telemetry was useful in determining when pack members were traveling together or apart and how long a breeding female wolf spent near her pups (e.g., 0-month-old pups were left unattended by their mother for as long as 17 days).

Music Therapy In The Modern Era: Three Discussions, Kate Pisarczyk, Sean Harty, Victoria Kleeman

Celebration of Learning

This Senior Inquiry presentation includes the findings of three Pre-Music therapy senior’s research. The three projects delve into very different, but important aspects of music therapy in our modern era. Sean Harty's Memory and Music delves into the impact of music on different parts of the aging brain in regards to memory recall. Music therapy is one avenue in order to assist this type of clientele. Victoria Kleeman's Synergy Should Tell the Story in Music Therapy explores the idea of creating synergy within the world of music therapy. Her discussion leads with the idea that the creation of synergy comes …

Combatting The Opioid Crisis On College Campuses: A Harm Reduction Approach, Corey L. Lepoudre

Celebration of Learning

College aged people are at a high risk of opioid misuse due to several risks including: an increased opioid misuse in people between the ages of 18-25, those who experience daily elevated stress, and those who live in metropolitan areas or in the Midwest region of the United States. Due to these risks, a harm reduction initiative geared toward college populations is beneficial to prevent a further increase in opioid misuse and overdose. A harm reduction approach was used to develop an educational toolkit for Quad City Harm Reduction to conduct a one-hour workshop for college faculty and students. Harm …

Creating Genderless God-Language Through Lutheran Liturgy, Eileen A. Ruppel

Celebration of Learning

Drawing on the work of feminist and queer theologies, this paper examines and challenges traditional God-language, proposing the implementation of genderless language in Christian worship liturgies. The Evangelical Lutheran Church in America (ELCA) is used as a model for potential methods of shifting God-language. This work focuses on God-language in Lutheran liturgy, focusing on Scripture, hymns, doctrine, and prayer. This work seeks to prove that implementing genderless God-language throughout the liturgy will provide ELCA leaders the opportunity to be more inclusive, while representing God’s transcendence beyond human conceptions such as gender.

The Role Of General Psychological Processes In The Association Between Parental Rejection And Lgb Youth Internalizing Problems, Brian Edmund James Richter

Open Access Dissertations

Upward of 70% of lesbian, gay, and bisexual (LGB) youth experience some degree of negative parental reaction to their sexual orientation, which is problematic in light of data documenting an association between parental rejection and internalizing problems in these youth. While emerging studies have begun to study mediating factors, this research is limited and has significant gaps. To the author’s knowledge, the current study is the first to examine longitudinal data in this area as well as to investigate general psychological processes (i.e., factors common to all youth and known to be linked to youth mental health outcomes) that may …

Impact Of Child And Family Teaming In A Child Welfare Agency, Madeline Roachell

Dissertations

Purpose. The purpose of this mixed-methods study was twofold, (1) to describe the family experiences of those who had a CFT and those who did not, and (2) to identify and describe the impact of child and family teams (CFTs) on reentry into foster care.

Methodology. The study used a mixed-methods approach collecting both quantitative and qualitative data. Quantitative data included archival data and an electronic survey. Qualitative data included in-depth interviews and narrative comments from the survey.

Findings. A careful analysis of the data resulted in nine major findings and three dominant themes. The dominant themes of the study …

Pathophysiology And Pathogenesis Of Endometriosis, Kathryn Vaubel

Nursing Student Class Projects (Formerly MSN)

No abstract provided.

Rheumatoid Arthritis, Ana Vigil

Nursing Student Class Projects (Formerly MSN)

No abstract provided.

Carbon Storage And Sequestration By Selected Tree Species In The University Of San Carlos – Talamban Campus’ (Usc-Tc) Nature Park, Cebu City, Philippines, Richard Parilla

CNU Journal of Higher Education

Increasing global warming as a result of an unprecedented increase in greenhouse gases in the atmosphere is a worldwide concern. Among the most important greenhouse gases in the atmosphere is carbon dioxide. The call for the reduction and sequestration of carbon dioxide is indeed very urgent. Urban greenspaces are seen to be an important player in reducing carbon dioxide. In this regard, this study looks into the carbon storage and sequestration potential by an endemic and introduced tree species in the nature park of the University of San Carlos – Talamban Campus (USC-TC), namely the molave (Vitex parviflora) and mahogany …

Genetically Engineered Mosquitoes, Zika And Other Arboviruses, Community Engagement, Costs, And Patents: Ethical Issues, Zahra Meghani, Christophe Boëte

Philosophy Faculty Publications

No abstract provided.

Joel Doe V. Boyertown Area School District

2018 Decisions

USDC for the Eastern District of Pennsylvania

Joel Doe V. Boyertown Area School District

2018 Decisions

USDC for the Eastern District of Pennsylvania

Tooms Cyprès Named New Dean Of Uab School Of Education, Staff

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No abstract provided.

The Outcomes Of Offering A Working Lunch Session In Improving Adolescent Students’ Assignment Completion Rate And Academic Achievement In Mathematics, Kristian Edgeman

Doctor of Education in Teacher Leadership Dissertations

A decline in academic motivation, organizational skills, and the desire to learn in adolescent students cause middle grade teachers to constantly look for ways of encouraging students to complete assignments on time and achieve academic growth. Tactics such as positive reinforcement and punishments are frequently offered to adolescent students with the purpose of encouraging academic motivation. The inclusion of zeros in the grade book, although a hodgepodge grading practice, is often used as a tool to boost student motivation in prompt assignment completion; however, there is a lack of research to support this. The current study was designed to analyze …

Site-1 Protease Deficiency Causes Human Skeletal Dysplasia Due To Defective Inter-Organelle Protein Trafficking, Yuji Kondo, Debabrata Patra, Et Al

Open Access Publications

Site-1 protease (S1P), encoded by MBTPS1, is a serine protease in the Golgi. S1P regulates lipogenesis, endoplasmic reticulum (ER) function, and lysosome biogenesis in mice and in cultured cells. However, how S1P differentially regulates these diverse functions in humans has been unclear. In addition, no human disease with S1P deficiency has been identified. Here, we report a pediatric patient with an amorphic and a severely hypomorphic mutation in MBTPS1. The unique combination of these mutations results in a frequency of functional MBTPS1 transcripts of approximately 1%, a finding that is associated with skeletal dysplasia and elevated blood lysosomal enzymes. We …

The Efficacy Of Coaching Interventions Forundergraduates To Increase Positive Coping Behavior: A Quantitative Quasi-Experiment, Anthony Jackson

CUP Ed.D. Dissertations

Across the United States, many administrators on college campuses are attempting to respond to the increased student need for mental health services; however, there is concern about colleges’ ability to meet the demand for mental health services in the long term. Using Folkman and Lazarus’ theory of transactional stress and coping, this quantitative quasi-experimental study attempted to determine if a significant difference in coping existed among participants both taking part and not taking part in a life-coaching program across time and if there was a significant mean difference in coping scores between participants who participated in a life coaching program …

July 26, 2018 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Gut Inflammatory Diseases, Infection, And Nutrition, Helieh S. Oz, Sung-Ling Yeh, Amedeo Amedei

Internal Medicine Faculty Publications

No abstract provided.

Irrigation Management, Environment, And Profits: Who Wins?, Emily O'Donnell

Department of Agricultural Economics: Dissertations, Theses, and Student Research

The impact of irrigation technology on farmers’ management strategies and resulting environmental benefits depends upon agronomic properties and market forces. We evaluate the role of deficit irrigation using soil moisture probe technology on corn yield and evapotranspiration, which is a measure of water use efficiency. Evapotranspiration represents the water that transits through the plant during planting to harvest (transpiration) and the evaporation from the soil into the environment, or the displaced water in the production process. We develop yield and evapotranspiration response functions to inform a constrained profit maximization model used to identify the optimal irrigation level across a variety …

Competition Among Three Forensically Important Blow Fly Species (Diptera: Calliphoridae): Phormia Regina, Lucilia Sericata, And Chrysomya Rufifacies, Amber Macinnis

School of Natural Resources: Dissertations, Theses, and Student Research

The aim of this study was to use interspecific competition between three species of blow flies (Diptera: Calliphoridae) to determine if interspecific competition might explain the successional patterns. A replacement series model was used for three species of blowflies: Phormia regina, Lucilia sericata, and Chrysomya rufifacies. A total of 20 maggots were used for each treatment and the proportion of each species was varied. The graphic evidence and the relative crowding coefficient of P. regina versus L. sericata indicated a significant competitive advantage of P. regina. One of the life history traits of L. sericata is that it oviposits on …

Hiv-1 Integrase-Targeted Short Peptides Derived From A Viral Protein R Sequence, Xue Zhi Zhao, Mathieu Métifiot, Evgeny Kiselev, Jacques Kessl, Kasthuraiah Maddali, Christophe Marchand, Mamuka Kvaratskhelia, Yves Pommier, Terrence R. Burke Jr.

Faculty Publications

HIV-1 integrase (IN) inhibitors represent a new class of highly effective anti-AIDS therapeutics. Current FDA-approved IN strand transfer inhibitors (INSTIs) share a common mechanism of action that involves chelation of catalytic divalent metal ions. However, the emergence of IN mutants having reduced sensitivity to these inhibitors underlies efforts to derive agents that antagonize IN function by alternate mechanisms. Integrase along with the 96-residue multifunctional accessory protein, viral protein R (Vpr), are both components of the HIV-1 pre-integration complex (PIC). Coordinated interactions within the PIC are important for viral replication. Herein, we report a 7-mer peptide based on the shortened Vpr …

Effects Of Drift Macroalgae On Sediment Nitrogen Cycling In Thalassia Testudinum Beds Of St. Joseph Bay, Fl, Erica Strope

Master of Science in Integrative Biology Theses

Anthropogenic nitrogen (N) loading and eutrophication can affect valuable ecosystem services and seagrass habitats by modifying structural and functional aspects of estuarine communities including increasing and prolonging macroalgae blooms. In some contexts, macroalgae may play a key role in N cycling pathways because they can alter sediment chemistry. Previous research has associated drift macroalgae blooms with elevated dissolved inorganic N concentrations in sediments as a result of increased remineralization of organic matter, but drift macroalgae effects on microbial N transformation pathways are not well understood. This study quantified the effects of macroalgae on estuarine N cycling in Thalassia testudinum seagrass …

Plant Community Composition, Floristic Quality, And Establishment Of Roadside Revegetation In Nebraska, Usa, Jonathan M. Soper

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Roadside revegetation poses a challenge and opportunity for biodiversity conservation, as the land area occupied by roadsides is not expected to decline in the future. In the context of roadside revegetation activities in rural regions dominated by agricultural land uses, revegetation efforts can establish plant communities that offer unique species that would otherwise be absent on the landscape. To determine the efficacy of roadside revegetation efforts in 1) providing plant communities of high biodiversity value and 2) meeting the expectations of roadside revegetation managers for establishment, we quantified botanical composition, floristic quality, and success in seeding efforts to meet manager …