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A Trans Influence And Π-Conjugation Effects On Ligand Substitution Reactions Of Pt(Ii) Complexes With Tridentate Pendant N/S-Donor Ligands, Grace A. Kinunda

Tanzania Journal of Science

The rate of displacement of the chloride ligands by three neutral nucleophiles (Nu) of different steric demands, namely thiourea (TU), N,N’-dimethylthiourea (DMTU) and N,N,N,’N-tetramethylthiourea (TMTU) in the complexes viz; [Pt(II)(bis(2-pyridylmethyl)amine)Cl]ClO4, (Pt1), [Pt(II){N-(2-pyridinylmethyl)-8-quinolinamine}Cl]Cl, (Pt2), [Pt(II)(bis(2-pyridylmethyl)sulfide)Cl]Cl, (Pt3) and [Pt(II){8-((2-pyridylmethyl)thiol)quinoline}Cl]Cl, (Pt4) was studied under pseudo first-order conditions as a function of concentration and temperature using a stopped-flow technique and UV-Visible spectrophotometry. The observed pseudo first-order rate constants for substitution reactions obeyed the simple rate law. The results have shown that the chloro ligand in Pt(N^S^N) complexes is more labile by two orders of magnitude than Pt(N^N^N) complexes due to the high trans labilizing …

In Silico Pharmacokinetic And Molecular Docking Studies Of N-Cinnamoyltetraketide Derivatives As Inhibitors Of Cyclooxygenase-2 Enzyme, Stephen S. Nyandoro, Daniel M. Shadrack, Joan J. E. Munissi, Egid B. Mubofu

Tanzania Journal of Science

Recent phytochemical analysis of Toussaintia orientalis leaves yielded series of novel bioactive N-cinnamoyltetraketide derivatives namely toussaintines A-G (t_1 - t_8) some portraying cytotoxicity against the triple negative aggressive human breast cancer cell line (MDA-MB-231) among other potencies. Despite having broad bioactivity spectrum, their general drug-likeness profiles and mode of action (simulated or actual) targeting any enzyme remains uninvestigated. In silico pharmacokinetic, drug-likeness descriptors and molecular docking of the compounds t_1-t_8 targeting inhibition of cyclooxygenase-2 (COX-2) enzyme were evaluated. The Lipinski Rule of Five heralded the pharmacokinetic properties of the studied metabolites. The studied compounds were docked with COX-2 following already …

Semisynthesis Of A Mellein-Type 3,4-Dihydroisocoumarin From Cashew Nut Shell Liquid (Cnsl), Clarence A. Mgina, Fatma Kadir

Tanzania Journal of Science

Mellein-type 3,4-dihydroisocoumarin 39 (i.e., 8-methoxy-3-tridecyl-3,4-dihydroisocoumarin or 8-methoxy-3-tridecylisochroman-1-one), and its precursors, namely, methyl 2-methoxy-6-pentadecylbenzoate (37), methyl 2-methoxy-6-pentadecanoylbenzoate (38) and (E)-methyl 2-methoxy-6-(pentadec-1-enyl)benzoate (19) were synthesized from anacardic acid (12) as a starting material obtained from Cashew Nut Shell Liquid (CNSL) in an overall yield of 78%. The transformation of 12 to 39 involved protection of the reactive phenolic and carboxylic acid groups of compound 12 through methylation followed by hydrogenation so as to saturate the mono-, di- and tri-unsaturated C15 chains of anacardic acid (12). Subsequent benzylic oxidation and reduction of the keto functional group with concomitant dehydration of the alcohol led …

One-Compound-Two-Pharmacophores: Design, Synthesis And Antimalarial Activities Of Chloroquinoline-Cassiarin, Thobias M. Kalenga, Monica M. Ndoile, Quintino A. Mgani

Tanzania Journal of Science

This paper describes the design and synthesis of a potential antimalarial compound, chloroquinoline-cassiarin (6) using 4,7-dichloroquinoline and the natural product barakol (1) extracted from the leaves of Cassia siamea as starting materials. In this paper a one compound-two-pharmacophores concept is introduced in which coupling of two known pharmacophores into one has been described. The concept is not only useful to organic synthesis but also to drug development researches. The synthesized compound 6 exhibited potent in vitro antimalarial activity at IC50 = 0.51 µM, and low toxicity where at 20 µM, 80% viability of HeLa cells was observed.

Ultrafast And Nonlinear Spectroscopy Of Nanomaterials, Rami Anthony Khoury

LSU Doctoral Dissertations

Ultrafast and nonlinear spectroscopies are implemented in the investigation of excited-state dynamics and structural properties of materials and nanomaterials. In the first study, the excited-state dynamics of size-dependent colloidal TiO₂-Au nanocomposites are investigated using ultrafast transient absorption spectroscopy. The dynamics corresponding to the plasmon depletion band are characterized by electron-phonon and phonon-phonon coupling lifetimes that are observed to be independent of the gold nanocluster shell thickness. The excited-state dynamics corresponding to the interband transition of gold is also spectrally overlapped with the interfacial electron transfer lifetime, which is shown to decrease as the nanocluster shell thickness increases. In …

Bioactivities Of Extracts, Debromolaurinterol And Fucosterol From Macroalgae Species, Sartaz Begum, Stephen S. Nyandoro, Amelia S. Buriyo, John J. Makangara, Joan J. E. Munissi, Sandra Duffy, Vicky M. Avery, Mate Erdelyi

Tanzania Journal of Science

Parasitic diseases including malaria, and other numerous microbial infections and physiological diseases are threatening the global population. Tanzanian coast shores are endowed with a variety of macroalgae (seaweeds), hitherto unsystematically explored to establish their biomedical potentials. Thus, antiplasmodial activity using malarial imaging assay, antimicrobial activity using microplate dilution technique, antioxidant activity using DPPH radical scavenging method and cytotoxicity using brine shrimp test were carried out on crude extracts from the selected species of algae (Acanthophora spicifera, Cystoseira myrica, Cystoseira trinodis, Laurencia filiformis, Padina boryana, Sargassum oligocystum, Turbinaria crateriformis, Ulva fasciata and Ulva reticulata) occurring along the coast of Tanzania. The …

Determination Of Toxic Diethylene Glycol In Toothpastes In Dar Es Salaam By High Performance Thin Layer Chromatography And Colorimetric Methods, John Andrew Marco Mahugija

Tanzania Journal of Science

The aim of this study was to determine the presence and the levels of diethylene glycol (DEG) in toothpaste products commonly used in Dar es Salaam. Forty five samples of different brands of imported and locally manufactured toothpastes were collected and processed prior to analysis. High performance thin layer chromatography (HPTLC) method was used for the qualitative detection of diethylene glycol in the toothpastes. In quantitative analysis, a colorimetric method that involved ultraviolet–visible (UV-Vis) spectrophotometric measurements of absorbances of prepared coloured samples and standards was used. DEG was found in 37.8% of the tested samples. The concentrations of the DEG …

In Silico Pharmacokinetic And Molecular Docking Studies Of N-Cinnamoyltetraketide Derivatives As Inhibitors Of Cyclooxygenase-2 Enzyme, Stephen S. Nyandoro, Daniel M. Shadrack, Joan J. E. Munissi, Egid B. Mubofu

Tanzania Journal of Science

Recent phytochemical analysis of Toussaintia orientalis leaves yielded series of novel bioactive N-cinnamoyltetraketide derivatives namely toussaintines A-G (t_1 - t_8) some portraying cytotoxicity against the triple negative aggressive human breast cancer cell line (MDA-MB-231) among other potencies. Despite having broad bioactivity spectrum, their general drug-likeness profiles and mode of action (simulated or actual) targeting any enzyme remains uninvestigated. In silico pharmacokinetic, drug-likeness descriptors and molecular docking of the compounds t_1-t_8 targeting inhibition of cyclooxygenase-2 (COX-2) enzyme were evaluated. The Lipinski Rule of Five heralded the pharmacokinetic properties of the studied metabolites. The studied compounds were docked with COX-2 following already …

Cost Effective Strategy For The Synthesis Of Azo Dyes By Using Cashew Nut Shell Liquid (Cnsl), Mathias Yohana, Monica M. Ndoile, Quintino A. Mgani

Tanzania Journal of Science

The synthesis and dyeing properties of two types of azo dyes are reported in this paper. The two types of dyes were obtained from coupling of amino cardanol with unsaturated anacardic acid [ACUSA (Aminocardanol unsaturated anacardic acid)] and saturated anacardic acid [ACSA (Aminocardanol saturated anacardic acid)] separately. Both, anacardic acid and aminocardanol were obtained from CNSL as their source material. ACSA dyes were solid and dark brown while ACUSA were gelatinous and dark red. The performance of both ACUSA and ACSA dyes was moderate on textile fabrics with varying cotton content. The dyeing efficiency of the ACUSA was better than …

In Vivo Antimycobacterial Studies Of Toussaintine A-Chitosan Nanocomposites, Edward Rwegasila, Joan J.E. Munissi, Egid B. Mubofu, Stephen S. Nyandoro, Paul Erasto

Tanzania Journal of Science

Chitosan (CS, molecular weight (MW) 20.2 kDA, stability of 210 °C and degree of deacetylation (DD) 73.31%) was obtained by deacetylation of chitin extracted from shrimp (Litopenaeus vannamei) shell wastes. The encapsulation of the studied bioactive natural product, toussaintine A (TA) isolated from the leaves of Toussaintia orientalis, on a chitosan-tripolyphosphate (CS/TPP) nanoformulation was attained through ionotropic gelation. Characterization of pure CS, CS/TPP and TA-CS/TPP nanocomposites was carried out by FTIR and SEM. The encapsulation efficiency and loading capacity of the TA were 69.33 and 0.46%, respectively. The in vitro release kinetics established an initial release of 27% of TA …

In Vivo Antimycobacterial Studies Of Toussaintine A-Chitosan Nanocomposites, Edward Rwegasila, Joan J.E. Munissi, Egid B. Mubofu, Stephen S. Nyandoro, Paul Erasto

Tanzania Journal of Science

Chitosan (CS, molecular weight (MW) 20.2 kDA, stability of 210 °C and degree of deacetylation (DD) 73.31%) was obtained by deacetylation of chitin extracted from shrimp (Litopenaeus vannamei) shell wastes. The encapsulation of the studied bioactive natural product, toussaintine A (TA) isolated from the leaves of Toussaintia orientalis, on a chitosan-tripolyphosphate (CS/TPP) nanoformulation was attained through ionotropic gelation. Characterization of pure CS, CS/TPP and TA-CS/TPP nanocomposites was carried out by FTIR and SEM. The encapsulation efficiency and loading capacity of the TA were 69.33 and 0.46%, respectively. The in vitro release kinetics established an initial release of 27% of TA …

Book Censorship In Nigeria: A Study Of Origin, Methods And Motivations, 1805-2018, Emmanuel Ifeduba

Library Philosophy and Practice (e-journal)

Twenty-first century Nigeria may be described as the era of democracy yet freedom to publish, which is one of the hallmarks of true democracy, seem to be endangered more than ever before. Conversation around this subject has, however, been superficial, lacking in both historical and empirical depth. The aim of this study, therefore, is to investigate the origin, methods and motivations of censorship in Nigeria with a view to deepening the understanding of this phenomenon. Quantitative and qualitative data were collected offline and online using document analysis and interviews were analysed by simple percentages and the constant comparative method. Findings …

Threshold Concepts, Action Poetry And The Health Professions: An Interview With Ray Land, Ha Neve, R Land, L Martindale

Peninsula Medical School

Hilary Neve and Linda Martindale, members of the editorial team for this special Issue of the International Journal of Practice-based Learning in Health and Social Care, undertook this interview with Ray Land in June 2018. The interview was transcribed verbatim and subsequently edited for publication. In this, Ray Land considers the impact of threshold concepts generally as well as key implications for the healthcare education and practice.

Complete Issue 7(4)

Speaker & Gavel

Complete digitized issue (volume 7, issue 4, May 1970) of Speaker & Gavel.

The Impact Of World War One On The Forests And Soils Of Europe, Drew Heiderscheidt

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

The First World War was one of the deadliest conflicts in human history thus far. With the human toll being over eight million deaths, and millions more wounded, and as such it has taken hold in peoples imaginations for over a hundred years. However, one overlooked impact of the war is the environmental impact it had. The forests of Europe were significantly changed, going from being diverse ecosystems pre-war to monocultures after the war, dominated by single species of trees. The soil was also affected, more heavily in some places, becoming contaminated with heavy metals, as well as becoming entirely …

Trefoil Factor 1 (Tff1) Expression In E3 And Ewd8 Breast Cancer Cell Lines, Jazmyn Mosqueda-Banuelos, Nicholas A. Pullen

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

The ability to identify and treat cancer early can drastically improve patient survival outcomes. While much effort is placed on anti-cancer therapeutics, a developing area of interest is the identification of cancer biomarkers for the early detection of different types of cancer. Trefoil factors (TFFs) are a family of proteins whose known functions suggest that they may be major contributors to cancer; however, these proteins are understudied in a disease state like cancer. In this work, we identify expression of TFF1 among varying cancer types. We then investigate the correlation between varying levels of TFF1 expression and the aggressiveness of …

Fashion Under The Swastika: An Analysis Of Women's Fashion During The Third Reich, Ayrika Johnson

Ursidae: The Undergraduate Research Journal at the University of Northern Colorado

This paper works to demonstrate women's fashion in Germany during WWII and how it was impacted by Nazi culture. Within Hitler's Germany, there was a desire to create a uniform community separate from the rest of the world, and greater than all others. Fashion is one way to analyze how the Nazis tried to accomplish this goal. The paper relies on speeches, magazines, and their fashion pages, and advertisement clippings to uncover the social, economic, and political factors at play. By using fashion as a means of expressing cultural, societal, economic, and political goals, the desires of the Nazi government …

All Good And Well?: The State Of Forensic Health And Wellness Scholarship, Carson S. Kay

Speaker & Gavel

Forensic educators and students face many competitive challenges while vying for trophies and titles. However, maintaining one’s health while preparing, traveling, and competing too often falls by the wayside. Although scholars have examined the health of forensic educators and students in the past, few current research agendas address the health concerns of the forensic community. With the exception of Carmack (2016) and her collaboration with Holm (2005, 2013, 2015), forensic scholars have not actively discussed how the activity affects student and educator wellbeing since 2004. Questions still remain regarding how the speech and debate community might feasibly promote a healthy …

Two Birds, One Stone: Integrating Communication Proficiency Development Into Existing Academic Courses, Yehudith Weinberger

Journal of Educational Research and Practice

This article discusses the pedagogical knowledge required to develop students' communication proficiencies as part of their academic experience, proposes a method of doing so, and illustrates that method using a recent example. Using the case-study approach, first, the challenge is presented while its complexity in the context of academic studies is analyzed. Then, with implementation of the conceptual framework of “disciplinary literacy,” an original solution is offered in the form of a rolling multistage task in a seminar course that was a part of the master’s in teaching program. The rolling multistage task revolves around the development of the pedagogical …

Application Of Jean Watson's Theory Of Transpersonal Caring In Nurses Practicing In A Pain Center, Patricia Malone Hubert

Seton Hall University DNP Final Projects

The aim of this project was to determine if an educational intervention utilizing Jean Watson’s Theory of Human Caring influences nurses’ level of awareness and practice of loving kindness to self and others. Watson’s paradigm of transpersonal caring is presented as a means to provide the compassionate care needed by patients with chronic pain, who are vulnerable to the comorbidities of depression and anxiety and often have poor outcomes. This quality improvement project was implemented with five Registered Nurses working in a pain center. A two-pronged intervention was structured to begin developing a Caritas Consciousness in Session 1 by focusing …

Antimicrobial Activity And Germination Conditions Of The Medicinal Plant Argemone Mexicana, Kelly Davidson, Teodora Najdeska, Danielle Orozco-Nunnelly

Summer Interdisciplinary Research Symposium

Commonly called the Mexican prickly poppy, Argemone mexicana is a stress-resistant member of the Papaveraceae family of plants that has been used in traditional medicine for centuries by indigenous communities in Mexico and Western parts of the United States. This plant has been used to treat a wide variety of ailments, including skin diseases and intestinal infections, with reported antimicrobial properties. However, these properties are poorly understood and no bioactive compounds have yet been identified in the plant to account for this antimicrobial action. Herein, we describe the growth conditions and preliminarily characterize the antibiotic effects of different parts of …

A Dam Passage Performance Standard Model For American Shad, Daniel S. Stich, Timothy F. Sheehan, Joseph D. Zydlewski

New Hampshire EPSCoR

Objectives for recovery of alosines commonly involve improving fish passage at dams during migration. However, a quantitative basis for dam passage performance standards is largely absent. We describe development of a stochastic life-history-based simulation model for American shad, Alosa sapidissima, to estimate effects of dam passage and migratory delay on abundance, spatial distribution of spawning adults, and demographic structuring in space and time. We used the Penobscot River, Maine, USA, as a case study to examine sensitivity of modeled population metrics and probability of achieving specific management goals to inputs. Spawner abundance and percentage of repeat spawners were most sensitive …

Alumni News | Warners Path Leads To Palm Beach County Sheriffs Office, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Modification Of Aminoacyl Trna Synthetase In Order To Incorporate An Unnatural Amino Acid, Grace Burkhart

Summer Interdisciplinary Research Symposium

Proteins allow daily processes in the cell to occur. A protein consists of amino acids. There are twenty natural amino acids coded for in the DNA of organisms. The natural amino acids can be modified to form unnatural amino acids (UAAs). UAAs have useful characteristics when inserted into a protein of a cell, like the ability of fluoresce, which makes their incorporation important in research. For an UAA to be incorporated into a protein, it must be bound to a transport RNA molecule by an enzyme called aminoacyl tRNA synthetase (aaRS). An existing aaRS was modified in E. Coli bacterial …

Schuellein Chair In The Biological Sciences, Dave Larsen

College of Arts and Sciences Newsroom

The University of Dayton has appointed Amit Singh as the Schuellein Chair in the Biological Sciences. Singh is an associate professor of biology and director of the biology graduate program. He joined the University faculty in 2007.

Parenting Advice And Regrets Of Empty-Nesters, Ashton Chapman, David G. Schramm

Human Development and Family Studies Faculty Publications

Objective: To identify the advice and regrets empty-nest parents have when reflecting on their experiences as parents, and to investigate the utility of the parenting pyramid framework for parent education on the basis of that advice and those regrets.

Background: The parenting pyramid specifies that the parent–child relationship, teaching, and corection are key components of parenting, and that they should be emphasized in that order or priority. However, the extent to which this model is reflective of what parents actually think or do, or wish they would have done, remains unclear.

Method: Empty-nesters were recruited through social media, professional e-mail …

Family Care Partners Of Chronically Ill Older Adults: The Role Of Uncertainty In Illness, Jillian Pine

Dissertations

Abstract This study integrated research on family care partners of older adults and

research on uncertainty in chronic illness. Previous findings were extended by examining care partners of older adults with multiple chronic conditions and highlighting early-stage undiagnosed cognitive impairment as a uniquely unclear condition. Participants were 45 women assisting community-dwelling, earlier generation older adults with multiple chronic health conditions and a prognosis of more than six months. Online survey data were used to test the hypotheses that increased illness uncertainty would be associated with increased care partner-recipient relationship strain and increased care partner perceived stress. This study also hypothesized …

Ms 023 Guide To Hebbel Hoff, Md, D. Phil.Papers (1956-1990), Hebbel Hoff (1907-1987)

Manuscript Finding Aids

The Hebbel Hoff, M.D., collection includes reprints and journal articles, a hospital survey, newsletters, a CV, and other ephemera. The material is loosely arranged by type of document. See more at MS 023.

2018-July-30-Gatton Welcomes New Residents, Fellow, Bill Gatton College Of Pharmacy, East Tennessee State University, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (July 30, 2018) — East Tennessee State University’s Bill Gatton College of Pharmacy welcomes several new residents and a fellow who will be furthering their postgraduate pharmacy training in various practice settings over the next few years. 

Laura Dollins, of Berea, Kentucky, is the first resident in Gatton’s new Postgraduate Year 1 (PGY1) Community-based Pharmacy Residency, a program created in partnership with Boone Drug and Healthcare in Boone, North Carolina. The program is designed to prepare community-based pharmacists as leaders and innovators through unique practice experiences, with the goal of elevating pharmacy practice and overall healthcare both …

2018-July-30-Pharmacy Welcome, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.