Digital Commons Network^™

Ion-Sensitive Field-Effect Transistors With Micropillared Gates For Measuring Cell Ion Exchange At Molecular Levels, Mohammad G. Abdallah, Rayan Khan, Christian Garcia, Young-Tae Kim, Samir M. Iqbal

Electrical and Computer Engineering Faculty Publications

The detection of small concentrations of cancer cells before cancer takes over the primary organ completely, or metastasizes to other areas of the body is important for early screening of cancer. One approach to address cancer early screening is through cell ion exchange bioelectricity, which characterizes voltage potential in non-neuronal cells to regulate shape changing, proliferation, differentiation, migration, and cancer formation. Herein, novel ion-sensitive field-effective transistor (ISFET) modality is shown to measure cell behavior during the change of cell properties at molecular levels. ISFETs produce low resistance signals and consume low power. The small size of ISFETs enables miniature diagnosis …

Communication Between Home And School For Parents Of Children With Chronic Illness, Keri Edwards

Theses and Dissertations

A child with chronic illness has a physical or behavioral condition that affects the child’s daily functioning, lasts longer than three months, and requires medical intervention such as medication, hospitalizations, and/or home care (Newacheck, McManus, & Fox, 2001). Chronic illness interferes with all areas of development, including physical, social, emotional, and cognitive development, and a growing number of children with chronic illnesses are attending school. Effective communication between parents and educators is essential so that accurate information about the nature and extent of the impact of chronic illness on children’s learning experiences and schooling can be shared and appropriate supports …

Signs & Symbols, Vol. 18, Fall 2018, Illinois State University, Department Of Sociology And Anthropology

Signs & Symbols

Newsletter of the Illinois State University Department of Sociology and Anthropology

(S)Expectations Abroad: Male Traveler Interactions With Southeast Asian Economies, Elliot J. Glotfelty, Glenn M. Miles

Dignity: A Journal of Analysis of Exploitation and Violence

Interacting with locals is a highlight of the tourism experience; however, these interactions may be accompanied by unsolicited propositions for the traveler to participate in the sex industry. Through the lens of Thailand’s largely visible sex industry, this work addresses issues of tourism and travel intertwined with the sex industry in greater Southeast Asia. Governments, a variety of businesses and individuals benefiting financially from a burgeoning sex tourism industry encourage persistence of a viable local sex trade. Although subtleties exist between human trafficking, the sex industry, and sex tourism, each can be intertwined. This article provides an overview of the …

Abuse Or Be Abused: Traumatic Memory, Sex Inequality, And Millennium As A Socio-Literary Device, Kate Rose

Dignity: A Journal of Analysis of Exploitation and Violence

This article applies the research of French psychiatrist Muriel Salmona to literary analysis of Stieg Larsson’s protagonist, Lisbeth Salander, in the Millennium trilogy (The Girl with the Dragon Tattoo, 2008; The Girl Who Played with Fire, 2009; The Girl Who Kicked the Hornet’s Nest, 2010). It suggests that Larsson’s novels may be useful in raising awareness of childhood sexual abuse, through reading neglected signs linked to the neurology of traumatic memory. In the tradition of Nordic noir novels, hyperboles in Salander’s sensationalized identity serve to magnify and bring to light a misunderstood social problem. The article …

Fact Book 2018, Planning, Research, And Policy Analysis

Fact Book (1988-2019)

Fact Book 2018 for Illinois State University

Outstanding Challenges In The Transferability Of Ecological Models, Katherine L. Yates, Phil J. Bouchet, M. Julian Caley, Kerrie Mengersen, Christophe F. Randin, Stephen Parnell, Alan H. Fielding, Andrew J. Bamford, Stephen Ban, A. Márcia Barbosa, Carsten F. Dormann, Jane Elith, Clare B. Embling, Gary N. Ervin, Rebecca Fisher, Susan Gould, Roland F. Graf, Edward J. Gregr, Patrick N. Halpin, Risto K. Heikkinen, Stefan Heinänen, Alice R. Jones, Periyadan K. Krishnakumar, Valentina Lauria, Hector Lozano-Montes, Laura Mannocci, Camille Mellin, Mohsen B. Mesgaran, Elena Moreno-Amat, Sophie Mormede, Emilie Novaczek, Steffen Oppel, Crespo G Ortuño, A. Townsend Peterson, Giovanni Rapacciuolo, Jason J. Roberts, Rebecca E. Ross, Kylie L. Scales, David Schoeman, Paul Snelgrove, Göran Sundblad, Wilfried Thuiller, Leigh G. Torres, Heroen Verbruggen, Lifei Wang, Seth Wenger, Mark J. Whittingham, Yuri Zharikov, Damaris Zurell, Ana M.M. Sequeira

School of Biological and Marine Sciences

Predictive models are central to many scientific disciplines and vital for informing management in a rapidly changing world. However, limited understanding of the accuracy and precision of models transferred to novel conditions (their 'transferability') undermines confidence in their predictions. Here, 50 experts identified priority knowledge gaps which, if filled, will most improve model transfers. These are summarized into six technical and six fundamental challenges, which underlie the combined need to intensify research on the determinants of ecological predictability, including species traits and data quality, and develop best practices for transferring models. Of high importance is the identification of a widely …

A White Paper On America's Family Values: The Facts About Child Maltreatment And The Child Welfare Financing System, Children's Advocacy Institute, University Of San Diego School Of Law

CAI Special Reports

No abstract provided.

Crossing The Century: Cross-Dressing In Turn-Of-The-Twentieth-Century San Francisco, Alexander Jin , '19

Senior Theses, Projects, and Awards

This paper explores cross-dressing in the San Francisco Bay Area at the turn-of-the- twentieth-century (c.1890-1910) and narrates the extraordinary lives of Edward James Livernash and Milton Matson, two individuals who were arrested on cross-dressing related charges in 1891 and 1895/1903 respectively. I attempt to show how the criminalization of cross-dressing was closely intertwined with the rise of modern sexuality, arguing that anti-cross-dressing laws operationalized the policing of bodies, the creation and maintenance of (fictionalized) fixed identities vis-à-vis binaries, and the reassertion of male power. I further argue that these shifts in how the state defined and regulated bodies demonstrates one …

In Vitro Transport Of Methotrexate By Drosophila Multidrug Resistance-Associated Protein., Agnes Karasik, András Váradi, Flóra Szeri

Department of Dermatology and Cutaneous Biology Faculty Papers

Methotrexate (MTX) is a widely used chemotherapeutic agent, immune suppressant and antimalarial drug. It is a substrate of several human ABC proteins that confer multidrug resistance to cancer cells and determine compartmentalization of a wide range of physiological metabolites and endo or xenobiotics, by their primary active transport across biological membranes. The substrate specificity and tissue distribution of these promiscuous human ABC transporters show a high degree of redundancy, providing robustness to these key physiological and pharmacological processes, such as the elimination of toxins, e.g. methotrexate from the body. A similar network of proteins capable of transporting methotrexate has been …

2018 October, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for October of 2018.

College Of Science And Mathematics 2018-2019

Faculty Senate: Membership Lists

No abstract provided.

Honors Research Symposium Program Fall 2018, University Honors Program, Georgia Southern University

Honors College: News & Publications (2008-2020)

No abstract provided.

Evolutionary Mismatch: Getting To The Root Of Modern Problems, Norman P. Li

Research Collection School of Social Sciences

Humans have experienced an enormous amount of technological progress in recent years. Owing to this progress, we are globally connected and can instantly communicate with family, friends, co-workers and multitudes of strangers. We are increasingly sheltered from harsh natural elements, dangerous animals and deadly wars, and have an incredible array of medicine to treat whatever ills us. Our entertainment options now include thousands of satellite television channels and millions of video games and videos. Our food options are just as numerous. Transportation is so fast and easy that we can visit places and do business with people all around the …

Fall 2018 Schedule Of Sustainability Events, Center For Sustainability, Georgia Southern University

Sustain Southern Event Schedules (2017-2021)

No abstract provided.

Blaunet: An R-Based Graphical User Interface Package To Analyze Blau Space, Michael Genkin, Cheng Wang, George Berry, Matthew E. Brashears

Research Collection School of Social Sciences

McPherson’s Blau space and affiliation ecology model is a powerful tool for analyzing the ecological competition among social entities, such as organizations, along a combination of sociodemographic characteristics of their members. In this paper we introduce the R-based Graphical User Interface (GUI) package Blaunet, an integrated set of tools to calculate, visualize, and analyze the statuses of individuals and social entities in Blau space, parameterized by multiple sociodemographic traits as dimensions. The package is able to calculate the Blau statuses at the nodal, dyadic, and meso levels based on three types of information: sociodemographic characteristics, group affiliations (e.g., membership in …

Fall 2018 Fast Facts, Georgia Southern University

Student Enrollment Infographics (2017-2022)

No abstract provided.

Swamp Money: The Opportunity And Uncertainty Of Investing In Wetland Mitigation Banking, Elan L. Spanjer

Northwestern University Law Review

In recent years, the wetland mitigation banking program has emerged as a favored mechanism for protecting the nation’s aquatic resources while allowing for economically beneficial development projects to proceed. Mitigation banks generate wetland credits, which in turn can be sold at a profit to developers who need them to offset wetland impacts. The number of mitigation banks has grown significantly in recent years, and the market has seen an influx of institutional investment. However, investors face significant risks and uncertainty, and many prospective investors lack access to information about wetland credit prices—which are neither reported to the regulatory authorities nor …

Decision Making In The Sciences: Understanding Heuristic Use By Students In Problem Solving, Elizabeth Csikar

STEMPS Theses & Dissertations

The purpose of this study was to examine the use of heuristics by students and gain insight into the thought process behind their problem-solving skills. The study used an adaptive narrative as the information delivery medium. An adaptive narrative was chosen because it could be designed to simulate decision making processes encountered in real world situations. Students enrolled in an introductory biology major class were chosen for the study because their fields of interest all require complex problem solving and decision-making skills. It was of interest to investigate what decisions were made when heuristics were given and how that may …

O.K. Computer: The Devolution Of Human Creativity And Granting Musical Copyrights To Artificially Intelligent Joint Authors, Jared Vasconcellos Grubow

Cardozo Law Review

No abstract provided.

Threats To Homeland Security: Reassessing The All-Hazards Perspective, 2nd Edition. Ed. By Richard J Kilroy. Hoboken, N.J.: Wiley, 2018., Mark T. Peters

Journal of Strategic Security

No abstract provided.

Upregulation Of Pdl1 Expression By Resveratrol And Piceatannol In Breast And Colorectal Cancer Cells Occurs Via Hdac3/P300-Mediated Nfkappab Signaling, Justin Lucas, Tze-Chen Hsieh, Dorota Halicka, Zbigniew Darzynkiewicz, Joseph M. Wu

NYMC Faculty Publications

Programmed cell death ligand 1 (PDL1) expressed in cancer cells interacting with its receptor programmed cell death 1 (PD1) expressed in immune cells represents a regulatory axis linked to the suppression and evasion of host immune functions. The blockade of PD1/PDL1 interaction using monoclonal antibodies has emerged as an effective therapy for several solid tumors; however, durable response has been observed in a subset of patients with PDL1-positive tumors. Thus, the understanding of the mechanisms responsible for the expression of PDL1 in tumor cells may help to improve the response to PDL1 blockade therapies. In this study, we investigated whether …

Judicial Review In An Age Of Hyper-Polarization And Alternative Facts, David A. Dana, Michael Barsa

San Diego Journal of Climate & Energy Law

This Article is organized as follows: Part I reviews the case law and commentary on judicial review of agency shifts in policy or practice, focusing on the technocratic case for deference and how recent political realities call such deference into question. Part II sets forth the background and history regarding fuel economy standards, leading to the Obama Administration’s adoption of standards in 2012 and the “midterm” review of those standards that Obama’s EPA declared final as of January 2017. Part II also reviews the legal issues surrounding Trump’s EPA’s “re-opening” of the midterm review. We suggest how courts could, and …

Hope On The Horizon For Offshore Wind Development? An Examination Of The Regulatory Framework Rhode Island Navigated To Make The Nation’S First Offshore Wind Farm A Reality, And The Implication For California’S Ability To Adopt A Similar Approach Under The Coastal Zone Management Act, Lauren Perkins

San Diego Journal of Climate & Energy Law

After establishing the reasons for why creating a more efficient permitting system is crucial, this Article examines the question of under what conditions BOEM, the lead agency in the offshore wind permitting process, delegates authority to a state so that it may permit a project in federal waters under the CZMA without running into federal preemptory roadblocks. This question is of utmost significance in California and Hawaii where projects utilizing floating turbine technology are proposed to be located in federal waters to take advantage of optimal wind gusts farther offshore. After examining the conditions favorable for federal delegation of the …

Metabolic Responses Of Meniscal Explants To Injury And Inflammation Ex Vivo, Alex E. Cook, Aaron M. Stoker, Emily V. Leary, Ferris M. Pfeiffer, James L. Cook

Student Publications

This study was designed to characterize metabolic responses of meniscal tissue explants to injury and inflammation. We hypothesized that impact injury and interleukin (IL-1β) stimulation of meniscal explants would result in significant increases in matrix metalloproteinase (MMP) activity and relevant cytokine production compared to controls. Mature canine meniscal explants (n = 9/group) were randomly assigned to: (i) IL-1β (0.1 ng/ml) treated (IL); (ii) 25% strain (25); (iii) 75% strain (75); (iv) 25% + IL-1β (25IL); (v) 75% + IL-1β (75IL); or (vi) 0% + no IL-1β control (NC). Explants were impacted at 100 mm/s to 0%, 25%, or 75% strain …

Chronic Intermittent Hypoxia Worsens Bleomycin-Induced Lung Fibrosis In Rats, Rudolf K. Braun, Oleg Broytman, Felix M. Braun, Jacqueline A. Brinkman, Andrew Clithero, Dhruvangkumar Modi, David F. Pegelow, Marlowe Eldridge, Mihaela Teodorescu

Student Publications

Obstructive sleep apnea (OSA) has been linked to increased mortality in pulmonary fibrosis. Its key feature, chronic intermittent hypoxia (CIH), can lead to oxidative stress and inflammation, known to lead to fibrotic pathology in other organs. We tested the effects of CIH in an animal model of bleomycin-induced lung fibrosis. Sprague Dawley rats were instilled intratracheally with bleomycin (Blm) or saline (Sal), and exposed to CIH or normal air (Norm) for 9 or 30 days. Pulmonary function was tested and lungs were harvested for histological and molecular analyses. In Blm-treated animals, 30days of CIH compared to Norm increased total lung …

Validity Of The Rule Of Threes And Anatomical Relationships In The Thoracic Spine, Clayton Oakley, Sarah Keim-Janssen, Joseph Pankratz, Travis Mccumber, Kevin Treffer, Anthony Olinger

Student Publications

Context

The location of the more superficial thoracic spinous processes is used to help osteopathic physicians locate the deeper and more difficult-to-palpate thoracic transverse processes. In 1979, Mitchell et al proposed the thoracic rule of threes to describe the relationship of the spinous processes to the transverse processes in the thoracic spine. This rule is currently taught at osteopathic medical schools. The rule of threes separates the thoracic vertebrae into 3 distinct groups, each with a different relationship between transverse processes and spinous processes. In 2006, Geelhoed et al proposed a new relationship between the spinous processes and transverse processes …

Genetic Variants Related To Cardiometabolic Traits Are Associated To B Cell Function, Insulin Resistance, And Diabetes Among American Indians: The Strong Heart Family Study, Poojitha Balakrishnan, Dhananjay Vaidya, Venkata Saroja Voruganti, Karin Haack, Jack W. Kent Jr., Kari E. North, Sandra Laston, Barbara V. Howard, Jason G. Umans, Elisa T. Lee

School of Medicine Publications

Background: Genetic research may inform underlying mechanisms for disparities in the burden of type 2 diabetes mellitus among American Indians. Our objective was to assess the association of genetic variants in cardiometabolic candidate genes with B cell dysfunction via HOMA-B, insulin resistance via HOMA-IR, and type 2 diabetes mellitus in the Strong Heart Family Study (SHFS).

Methods and Results: We examined the association of variants, previously associated with cardiometabolic traits (∼200,000 from Illumina Cardio MetaboChip), using mixed models of HOMA-B residuals corrected for HOMA-IR (cHOMA-B), log transformed HOMA-IR, and incident diabetes, adjusted for age, sex, population stratification, and familial relatedness. …

European Cherry Fruit Fly Rhagoletis Cerasi (Linnaeus), Lori R. Spears, Diane G. Alston

All Current Publications

European cherry fruit fly (ECFF) is a new invasive cherry-infesting pest from Europe. It was first detected in the U.S. in New York in 2017. This fact sheet describes it and includes life history, plant hosts, damage symptoms, monitoring, and management.

Clover Root Curculio (Sitona Hispidulus F.), Kaitlin Rim, Steven Price, Ricardo Ramirez

All Current Publications

The clover root curculio is an important agricultural pest in forage production systems. Adult beetles feed on the host plant leaves while the damaging larval stage feeds on the roots below ground. Heavy larval feeding has been associated with reduced stand establishment, disruption of nutrient and water uptake, increased secondary plant pathogen infection, decreased winter plant survival, delayed green-up, and reductions in forage quality and yield. Due to the hidden nature of eggs and larvae in the soil, CRC has been overlooked and damage is often misdiagnosed as nutrient deficiencies or pathogens. Historically, applications of chlorinated hydrocarbons, carbamates, and organophosphates …