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2018

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The Rider (2018-10-22), Victor G. Ramirez Oct 2018

The Rider (2018-10-22), Victor G. Ramirez

The Rider Archives

Vol.4 No.9


Gardner-Webb Community Partners With Non-Profit To Collect Food For Hungry Children, Office Of University Communications Oct 2018

Gardner-Webb Community Partners With Non-Profit To Collect Food For Hungry Children, Office Of University Communications

Gardner-Webb NewsCenter Archive

One in three children in Cleveland County, N.C., do not always know where they will find their next meal, according to the Southeastern University Consortium for Food Security and Health. Through the Little Bulldog Backpack project, Gardner-Webb University Registrar Lou Ann Scates and Biology Professor Susan Manahan have made it their mission to provide meals for these hungry children. To assist the project, Gardner-Webb officials have designated November as “Feed Our Children” month.


Optical And X-Ray Technology Synergies Enabling Diagnostic And Therapeutic Applications In Medicine, Brian W. Pogue, Brian C. Wilson Oct 2018

Optical And X-Ray Technology Synergies Enabling Diagnostic And Therapeutic Applications In Medicine, Brian W. Pogue, Brian C. Wilson

Dartmouth Scholarship

X-ray and optical technologies are the two central pillars for human imaging and therapy. The strengths of x-rays are deep tissue penetration, effective cytotoxicity, and the ability to image with robust projection and computed-tomography methods. The major limitations of x-ray use are the lack of molecular specificity and the carcinogenic risk. In comparison, optical interactions with tissue are strongly scatter dominated, leading to limited tissue penetration, making imaging and therapy largely restricted to superficial or endoscopically directed tissues. However, optical photon energies are comparable with molecular energy levels, thereby providing the strength of intrinsic molecular specificity. Additionally, optical technologies are …


Oa Week 2018, Marisol Ramos Oct 2018

Oa Week 2018, Marisol Ramos

UConn Library Presentations

Presentation of the benefits of Open Access, as part of exhibit to celebrate Open Access Week 2018 at the UConn Library.


The Open Science Framework & Reproducible Research: A New Space For Scholars & Librarians, Amanda Izenstark, Andrée Rathemacher Oct 2018

The Open Science Framework & Reproducible Research: A New Space For Scholars & Librarians, Amanda Izenstark, Andrée Rathemacher

Technical Services Faculty Presentations

Slides from a presentation, "The Open Science Framework & Reproducible Research: A New Space for Scholars & Librarians," presented at the NELA & RILA Joint 2018 Annual Conference, Welcome: The Library is Your Space, on October 22, 2018 in Warwick, Rhode Island.

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Room: Greenwich

The Open Science Framework is a tool created to help address two crises in research: transparency and reproducibility. In this session, learn more about the reproducibility crisis and how librarians’ knowledge of the Open Science Framework can help researchers at all levels improve and share their work.

ALS Academic Librarians Section

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Additional files include …


Crow's Nest, October 22, 2018, Crow's Nest Staff Oct 2018

Crow's Nest, October 22, 2018, Crow's Nest Staff

Crow's Nest

The October 22, 2018, issue of the Crow's Nest.


The Effect Of Energy-Matched Exercise Intensity On Brain-Derived Neurotrophic Factor And Motor Learning, Jessica F. Baird, Mary E. Gaughan, Heath M. Saffer, Mark A. Sarzynski, Troy M. Herter, Stacy L. Fritz, Dirk B. Den Ouden, Jill Campbell Stewart Oct 2018

The Effect Of Energy-Matched Exercise Intensity On Brain-Derived Neurotrophic Factor And Motor Learning, Jessica F. Baird, Mary E. Gaughan, Heath M. Saffer, Mark A. Sarzynski, Troy M. Herter, Stacy L. Fritz, Dirk B. Den Ouden, Jill Campbell Stewart

Communication Sciences and Disorders Faculty Articles and Research

Background

Pairing a bout of high-intensity exercise with motor task practice can enhance motor learning beyond task practice alone, which is thought, in part, to be facilitated by an exercise-related increase in brain-derived neurotrophic factor (BDNF). The purpose of the current study was to examine the effect of different exercise intensities on BDNF levels and motor learning while controlling for exercise-related energy expenditure.

Methods

Forty-eight young, healthy participants were assigned to one of three groups: high-intensity exercise [High], low-intensity exercise [Low], or quiet rest [Rest]. The duration of the exercise bouts were individually adjusted so that each participant expended 200 …


Am I Schizophrenic? Surviving Life And Death Situations, John Connolly B.Ed., Ma Oct 2018

Am I Schizophrenic? Surviving Life And Death Situations, John Connolly B.Ed., Ma

International Journal of Aquatic Research and Education

No abstract provided.


Design, Synthesis, And Evaluation Of Amphiphilic Cyclic And Linear Peptides Composed Of Hydrophobic And Positively-Charged Amino Acids As Antibacterial Agents, Neda Riahifard, Saghar Mozaffari, Taibah Aldakhil, Francisco Nunez, Qamar Alshammari, Saud Alshammari, Jason Yamaki, Keykavous Parang, Rakesh Kumar Tiwari Oct 2018

Design, Synthesis, And Evaluation Of Amphiphilic Cyclic And Linear Peptides Composed Of Hydrophobic And Positively-Charged Amino Acids As Antibacterial Agents, Neda Riahifard, Saghar Mozaffari, Taibah Aldakhil, Francisco Nunez, Qamar Alshammari, Saud Alshammari, Jason Yamaki, Keykavous Parang, Rakesh Kumar Tiwari

Pharmacy Faculty Articles and Research

Antimicrobial peptides (AMPs) contain amphipathic structures and are derived from natural resources. AMPs have been found to be effective in treating the infections caused by antibiotic-resistant bacteria (ARB), and thus, are potential lead compounds against ARB. AMPs’ physicochemical properties, such as cationic nature, amphiphilicity, and their size, will provide the opportunity to interact with membrane bilayers leading to damage and death of microorganisms. Herein, AMP analogs of [R4W4] were designed and synthesized by changing the hydrophobicity and cationic nature of the lead compound with other amino acids to provide insights into a structure-activity relationship against selected …


The Guardian, Week Of October 22, 2018, Wright State University Student Body Oct 2018

The Guardian, Week Of October 22, 2018, Wright State University Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of October 22, 2018. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.


Soybean Response To Dicamba: Associated Injury Criteria And Development Of A Model To Predict Yield Loss, Matthew Ryan Foster Oct 2018

Soybean Response To Dicamba: Associated Injury Criteria And Development Of A Model To Predict Yield Loss, Matthew Ryan Foster

LSU Doctoral Dissertations

In research conducted using indeterminate soybean [Glycine max (L.) Merr.], fourteen injury criteria observed following dicamba at 0.6 to 280 g ae ha-1 (1/1000 to ½ of 560 g ha-1 use rate) were rated using a scale of 0= no injury, 1= slight, 2= slight to moderate, 3= moderate, 4= moderate to severe, and 5= severe. Greatest crop injury 15 d after treatment (DAT) was observed following dicamba applied at 0.6 to 4.4 g ha-1 at V3/V4 for upper canopy pale leaf margins (3.8 to 4.2) and at R1/R2 for terminal leaf cupping (4.1 to 5.0) …


Assessing The Diversity Of The E-Collection Of The William H. Hannon Library; A Phased Project, Marie Kennedy, Aisha Conner-Gaten, Jamie Hazlitt, Javier Garibay, Marisa Ramirez Oct 2018

Assessing The Diversity Of The E-Collection Of The William H. Hannon Library; A Phased Project, Marie Kennedy, Aisha Conner-Gaten, Jamie Hazlitt, Javier Garibay, Marisa Ramirez

Librarian Publications & Presentations

The American Library Association’s 1982 statement on Diversity in Collection Development reminds librarians of our professional responsibility “to select and support the access to materials on all subjects that meet, as closely as possible, the needs, interests, and abilities of all persons in the community the library serves. This includes materials that reflect political, economic, religious, social, minority, and sexual issues.” The William H. Hannon (WHH) Library’s vision statementaffirms that the library views itself as Bridge, Gateway, Agora, and Enterprise. To ensure that our materials collection aligns with our institutional vision and meets the research needs of our diverse campus …


University Of Northern Iowa Faculty Senate Meeting Minutes, October 22, 2018, University Of Northern Iowa. Faculty Senate. Oct 2018

University Of Northern Iowa Faculty Senate Meeting Minutes, October 22, 2018, University Of Northern Iowa. Faculty Senate.

Documents - Faculty Senate

Meeting minutes from the Faculty Senate of the University of Northern Iowa.


Aplu Adaptive Courseware Grant, A Case Study: Implementation At The University Of Mississippi, Patti O’Sullivan Oct 2018

Aplu Adaptive Courseware Grant, A Case Study: Implementation At The University Of Mississippi, Patti O’Sullivan

Current Issues in Emerging eLearning

Learning Management Systems (LMS) have been the main vehicle for delivering and managing e-learning courses in educational, business, governmental and vocational learning settings. Since the mid-nineties there is a plethora of LMS in the market with a vast array of features. The increasing complexity of these platforms makes LMS evaluation a hard and demanding process that requires a lot of knowledge, time, and effort. Nearly 50% of respondents in recent surveys have indicated they seek to change their existing LMS primarily due to user experience issues. Yet the vast majority of the extant literature focuses only on LMS capabilities in …


Yes We Can! Exciting Progress And Prospects For Controlling Invasives On Islands And Beyond, Daniel Simberloff, Brad Keitt, David Will, Nick Holmes, Erin Pickett, Piero Genovesi Oct 2018

Yes We Can! Exciting Progress And Prospects For Controlling Invasives On Islands And Beyond, Daniel Simberloff, Brad Keitt, David Will, Nick Holmes, Erin Pickett, Piero Genovesi

Western North American Naturalist

Eradication and maintenance management of island invasive species have long histories, and incremental improvements of existing technologies plus occasional novel approaches have led to more challenging targets and increased success rates in certain categories. Many nonnative mammals have been eradicated from islands, as have several nonnative birds, insects, and plants. Hundreds of rat populations have been eliminated, with a success rate over 80%, and islands over 10,000 ha are now feasible targets. Mouse eradication has proven more challenging, but aerial broadcast of anticoagulant toxins has led to increased success. Carnivore eradication—especially of feral housecats and foxes—has been frequently attempted with …


Hominoid Intraspecific Cranial Variation Mirrors Neutral Genetic Diversity, Julia M. Zichello, Karen L. Baab, Kieran P. Mcnulty, Christopher J. Raxworthy, Michael E. Steiper Oct 2018

Hominoid Intraspecific Cranial Variation Mirrors Neutral Genetic Diversity, Julia M. Zichello, Karen L. Baab, Kieran P. Mcnulty, Christopher J. Raxworthy, Michael E. Steiper

Publications and Research

Natural selection, developmental constraint, and plasticity have all been invoked as explanations for intraspecific cranial variation in humans and apes. However, global patterns of human cranial variation are congruent with patterns of genetic variation, demonstrating that population history has influenced cranial variation in humans. Here we show that this finding is not unique to Homo sapiens but is also broadly evident across extant ape species. Specifically, taxa that exhibit greater intraspecific cranial shape variation also exhibit greater genetic diversity at neutral autosomal loci. Thus, cranial shape variation within hominoid taxa reflects the population history of each species. Our results suggest …


Week Of October 22, 2018, New York Medical College Oct 2018

Exploring Linguistic Space Occupied By The Teachers And Students Of An Esl Classroom In Gilgit-Baltistan, Pakistan: Comparisons Across Gender, Zaheer Abbas, Musa Ali, Safeer Hussain Oct 2018

Exploring Linguistic Space Occupied By The Teachers And Students Of An Esl Classroom In Gilgit-Baltistan, Pakistan: Comparisons Across Gender, Zaheer Abbas, Musa Ali, Safeer Hussain

Journal of Educational Research and Innovation

Classroom talk plays a key role in language learning especially in English as second language (ESL) classrooms. Therefore, in this study the linguistic space occupied by the teacher and students in an ESL classroom has been investigated. A descriptive and exploratory approach was employed and videotaping was used for data collection during five consecutive classroom lessons. Results revealed that the teacher occupied most of the linguistics space (60%) as compared to the students (40%). The average word count of boys (56%) was comparatively higher than that of girls’ word count (44%). This study reports important insights into the patterns of …


A Multi-Tissue Full Lifespan Epigenetic Clock For Mice., Michael J Thompson, Karolina Chwiałkowska, Liudmilla Rubbi, Aldons J Lusis, Richard C Davis, Anuj Srivastava, Ron Korstanje, Gary A Churchill, Steve Horvath, Matteo Pellegrini Oct 2018

A Multi-Tissue Full Lifespan Epigenetic Clock For Mice., Michael J Thompson, Karolina Chwiałkowska, Liudmilla Rubbi, Aldons J Lusis, Richard C Davis, Anuj Srivastava, Ron Korstanje, Gary A Churchill, Steve Horvath, Matteo Pellegrini

Faculty Research 2018

Human DNA-methylation data have been used to develop highly accurate biomarkers of aging ("epigenetic clocks"). Recent studies demonstrate that similar epigenetic clocks for mice (Mus Musculus) can be slowed by gold standard anti-aging interventions such as calorie restriction and growth hormone receptor knock-outs. Using DNA methylation data from previous publications with data collected in house for a total 1189 samples spanning 193,651 CpG sites, we developed 4 novel epigenetic clocks by choosing different regression models (elastic net- versus ridge regression) and by considering different sets of CpGs (all CpGs vs highly conserved CpGs). We demonstrate that accurate age …


Modulation Of Hypoxia-Induced Chemoresistance To Polymeric Micellar Cisplatin: The Effect Of Ligand Modification Of Micellar Carrier Versus Inhibition Of The Mediators Of Drug Resistance, Hoda Soleymani Abyaneh, Amir Hassan Soleimani, Mohammad Reza Vakili, Rania Soudy, Kamaljit Kaur, Francesco Cuda, Ali Tavassoli, Afsaneh Lavasanifar Oct 2018

Modulation Of Hypoxia-Induced Chemoresistance To Polymeric Micellar Cisplatin: The Effect Of Ligand Modification Of Micellar Carrier Versus Inhibition Of The Mediators Of Drug Resistance, Hoda Soleymani Abyaneh, Amir Hassan Soleimani, Mohammad Reza Vakili, Rania Soudy, Kamaljit Kaur, Francesco Cuda, Ali Tavassoli, Afsaneh Lavasanifar

Pharmacy Faculty Articles and Research

Hypoxia can induce chemoresistance, which is a significant clinical obstacle in cancer therapy. Here, we assessed development of hypoxia-induced chemoresistance (HICR) against free versus polymeric cisplatin micelles in a triple negative breast cancer cell line, MDA-MB-231. We then explored two strategies for the modulation of HICR against cisplatin micelles: a) the development of actively targeted micelles; and b) combination therapy with modulators of HICR in MDA-MB-231 cells. Actively targeted cisplatin micelles were prepared through surface modification of acetal-poly(ethylene oxide)-poly(-carboxyl-"-caprolactone) (acetal-PEO-PCCL) micelles with epidermal growth factor receptor (EGFR)-targeting peptide, GE11 (YHWYGYTPQNVI). Our results showed that hypoxia induced resistance against free and …


Increased Sod2 In The Diaphragm Contributes To Exercise-Induced Protection Against Ventilator-Induced Diaphragm Dysfunction, Aaron B. Morton, Ashley J. Smuder, Michael P. Wiggs, Stephanie E. Hall, Bumsoo Ahn, J. Matthew Hinkley, Noriko Ichinoseki-Sekine, Andres Mor Huertas, Mustafa Ozdemir, Toshinori Yoshihara, Nicholas R. Wawrzyniak, Scott K. Powers Oct 2018

Increased Sod2 In The Diaphragm Contributes To Exercise-Induced Protection Against Ventilator-Induced Diaphragm Dysfunction, Aaron B. Morton, Ashley J. Smuder, Michael P. Wiggs, Stephanie E. Hall, Bumsoo Ahn, J. Matthew Hinkley, Noriko Ichinoseki-Sekine, Andres Mor Huertas, Mustafa Ozdemir, Toshinori Yoshihara, Nicholas R. Wawrzyniak, Scott K. Powers

Health & Kinesiology Faculty Publications and Presentations

Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, prolonged MV results in rapid diaphragmatic atrophy and contractile dysfunction, collectively termed ventilator-induced diaphragm dysfunction (VIDD). Recent evidence reveals that endurance exercise training, performed prior to MV, protects the diaphragm against VIDD. While the mechanism(s) responsible for this exercise-induced protection against VIDD remain unknown, increased diaphragm antioxidant expression may be required. To investigate the role that increased antioxidants play in this protection, we tested the hypothesis that elevated levels of the mitochondrial antioxidant enzyme superoxide dismutase 2 (SOD2) is required to achieve exercise-induced protection against VIDD. Cause …


Thermal And Mechanical Energy Harvesting Using Lead Sulfide Colloidal Quantum Dots, Taher Ghomian Oct 2018

Thermal And Mechanical Energy Harvesting Using Lead Sulfide Colloidal Quantum Dots, Taher Ghomian

LSU Doctoral Dissertations

The human body is an abundant source of energy in the form of heat and mechanical movement. The ability to harvest this energy can be useful for supplying low-consumption wearable and implantable devices. Thermoelectric materials are usually used to harvest human body heat for wearable devices; however, thermoelectric generators require temperature gradient across the device to perform appropriately. Since they need to attach to the heat source to absorb the heat, temperature equalization decreases their efficiencies. Moreover, the electrostatic energy harvester, working based on the variable capacitor structure, is the most compatible candidate for harvesting low-frequency-movement of the human body. …


The Praxis Of Deceleration: Recovery As "Inner Work, Public Act", Marisol Cortez Ph.D. Oct 2018

The Praxis Of Deceleration: Recovery As "Inner Work, Public Act", Marisol Cortez Ph.D.

Academic Labor: Research and Artistry (2017-2022 archives)

Originally published in Deceleration and presented at the 2017 meeting of the Association for the Study of Literature and the Environment, this short essay details the vision and praxis behind an online journal of environmental justice co-edited by the author alongside environmental journalist Gregory Harman. In this essay, I situate the evolution of this project in relation to our precarious institutional positions as writers with disabilities who consequently work in the spaces between academia, journalism, activism, and creative writing. This positionality has in turn placed Deceleration in conversation with degrowth and allied movements around the world, which challenge the disabling …


Triple Diagnostic Accuracy On Early Stage Breast Cancer At Dr. Cipto Mangunkusumo And Persahabatan General Hospital, Diani Kartini, Ika Megatia, Sawitri Darmiati, Primariadewi Rustamadji, Setyawati Budiningsih Oct 2018

Triple Diagnostic Accuracy On Early Stage Breast Cancer At Dr. Cipto Mangunkusumo And Persahabatan General Hospital, Diani Kartini, Ika Megatia, Sawitri Darmiati, Primariadewi Rustamadji, Setyawati Budiningsih

The New Ropanasuri Journal of Surgery

Introduction. Breast cancer is the most common cancer in Indonesia with incidence rate 40.3 per 100.000 women and mortality rate 16.6 per 100.000women. On early stage, the decision for operative procedure (i.e. mastectomy) requires intraoperative frozen section to assess malignancy; which is mostly unavailable in secondary hospitals. The triple diagnostic (TD) test consists of physical examination, breast ultrasonography and fine needle aspiration biopsy is an accurate and simple preoperative diagnostic method that may solve the problem. The study aimed to find out conformance of the triple diagnostic to histopathology findings in those with breast lump where the malignancy was suspected. …


Ct Scan As A Diagnostic Modality Of Gastrointestinal Stromal Tumor: A Systematic Review, Yarman Mazni, Rizky Dk Robby Oct 2018

Ct Scan As A Diagnostic Modality Of Gastrointestinal Stromal Tumor: A Systematic Review, Yarman Mazni, Rizky Dk Robby

The New Ropanasuri Journal of Surgery

Introduction. Preoperative diagnosis of GIST is an important factor in the management. However, due to the rarity of the case, there is a controversy about the accuracy of CT scan as an accurate diagnostic tool. Therefore, a systematic review is required to find out the answer. Method. A review was conducted to find out evidence of the highest level regarding the accuracy of CT scan as a diagnostic modality of GIST. The study addressed to find out the sensitivity, specificity, positive and negative predictive values. A literature search carried out in database sites i.e. PubMed, ClinicalKey, ScienceDirect, and Cochrane using …


Survival Analysis In Young–Age Breast Cancer And Related Clinicopathologic Factors At Dr. Cipto Mangunkusumo General Hospital 2008–2015, Erwin D. Yulian, Adrian Salim Oct 2018

Survival Analysis In Young–Age Breast Cancer And Related Clinicopathologic Factors At Dr. Cipto Mangunkusumo General Hospital 2008–2015, Erwin D. Yulian, Adrian Salim

The New Ropanasuri Journal of Surgery

Introduction. Various cancer registrations and reports had confirmed the higher proportion of young women with breast cancer in Asian countries. This mandates special attention for clinician since this group of patients need different management approach, especially regarding the more aggressive biological behavior, worse prognosis and the escalating psychosocial burden that young women endure. We conducted a study to describe the clinicopathological characteristics of young–aged breast cancer in Indonesia and its relationship with overall survival. Method. This study is a survival analysis using samples all young–aged women with histologically–proven cancer diagnosis that underwent treatment (surgery and/or chemotherapy and/or irradiation and/or hormonal …


Sagp Annual Meeting October 20 To 21 2018, Anthony Preus Oct 2018

Sagp Annual Meeting October 20 To 21 2018, Anthony Preus

The Society for Ancient Greek Philosophy Newsletter

No abstract provided.


Velocity-Resolved Reverberation Mapping Of Five Bright Seyfert 1 Galaxies, G. De Rosa, M. M. Fausnaugh, C. J. Grier, B. M. Peterson, K. D. Denney, Keith Horne, M. C. Bentz, S. Ciroi, Elena Dalla Bontà, M. D. Joner, S. Kaspi, C. S. Kochanek, R. W. Pogge, S. G. Sergeev, M. Vestergaard, S. M. Adams, J. Antognini, C. Araya Salvo, E. Armstrong, J. Bae, A. J. Barth, T. G. Beatty, A. Bhattacharjee, G. A. Borman, T. A. Boroson, M. C. Bottorff, J. E. Brown, J. S. Brown, M. S. Brotherton, C. T. Coker, C. Clanton, V. Cracco, S. M. Crawford Oct 2018

Velocity-Resolved Reverberation Mapping Of Five Bright Seyfert 1 Galaxies, G. De Rosa, M. M. Fausnaugh, C. J. Grier, B. M. Peterson, K. D. Denney, Keith Horne, M. C. Bentz, S. Ciroi, Elena Dalla Bontà, M. D. Joner, S. Kaspi, C. S. Kochanek, R. W. Pogge, S. G. Sergeev, M. Vestergaard, S. M. Adams, J. Antognini, C. Araya Salvo, E. Armstrong, J. Bae, A. J. Barth, T. G. Beatty, A. Bhattacharjee, G. A. Borman, T. A. Boroson, M. C. Bottorff, J. E. Brown, J. S. Brown, M. S. Brotherton, C. T. Coker, C. Clanton, V. Cracco, S. M. Crawford

Faculty Publications

We present the first results from a reverberation-mapping campaign undertaken during the first half of 2012, with additional data on one active galactic nucleus (AGN) (NGC 3227) from a 2014 campaign. Our main goals are (1) to determine the black hole masses from continuum-Hβ reverberation signatures, and (2) to look for velocity-dependent time delays that might be indicators of the gross kinematics of the broad-line region. We successfully measure Hβ time delays and black hole masses for five AGNs, four of which have previous reverberation mass measurements. The values measured here are in agreement with earlier estimates, though there is …


R1 Retrotransposons In The Nucleolar Organizers Of Drosophila Melanogaster Are Transcribed By Rna Polymerase I Upon Heat Shock, Himanshu S. Raje, Molly E. Lieux, Patrick J. Dimario Oct 2018

R1 Retrotransposons In The Nucleolar Organizers Of Drosophila Melanogaster Are Transcribed By Rna Polymerase I Upon Heat Shock, Himanshu S. Raje, Molly E. Lieux, Patrick J. Dimario

Faculty Publications

The ribosomal RNA genes (rDNA) of Drosophila melanogaster reside within centromere-proximal nucleolar organizers on both the X and Y chromosomes. Each locus contains between 200–300 tandem repeat rDNA units that encode 18S, 5.8S, 2S, and 28S ribosomal RNAs (rRNAs) necessary for ribosome biogenesis. In arthropods like Drosophila, about 60% of the rDNA genes have R1 and/or R2 retrotransposons inserted at specific sites within their 28S regions; these units likely fail to produce functional 28S rRNA. We showed earlier that R2 expression increases upon nucleolar stress caused by the loss of the ribosome assembly factor, Nucleolar Phosphoprotein of 140 kDa (Nopp140). …


Gene Gangs Of The Chloroviruses: Conserved Clusters Of Collinear Monocistronic Genes, Phillip Seitzer, Adrien Jeanniard, Fangrui Ma, James L. Van Etten, Marc T. Facciotti, David D. Dunigan Oct 2018

Gene Gangs Of The Chloroviruses: Conserved Clusters Of Collinear Monocistronic Genes, Phillip Seitzer, Adrien Jeanniard, Fangrui Ma, James L. Van Etten, Marc T. Facciotti, David D. Dunigan

Nebraska Center for Virology: Faculty Publications

Chloroviruses (family Phycodnaviridae) are dsDNA viruses found throughout the world’s inland waters. The open reading frames in the genomes of 41 sequenced chloroviruses (330 + 40 kbp each) representing three virus types were analyzed for evidence of evolutionarily conserved local genomic “contexts”, the organization of biological information into units of a scale larger than a gene. Despite a general loss of synteny between virus types, we informatically detected a highly conserved genomic context defined by groups of three or more genes that we have termed “gene gangs”. Unlike previously described local genomic contexts, the definition of gene gangs requires only …