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2018 November 13 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Parkersburg Newspaper Writes About Wyatts Experiment On International Space Station, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Crystallographic And Computational Characterization Of Methyl Tetrel Bonding In S-Adenosylmethionine-Dependent Methyltransferases, Raymond C. Trievel, Steve Scheiner

Chemistry and Biochemistry Faculty Publications

Tetrel bonds represent a category of non-bonding interaction wherein an electronegative atom donates a lone pair of electrons into the sigma antibonding orbital of an atom in the carbon group of the periodic table. Prior computational studies have implicated tetrel bonding in the stabilization of a preliminary state that precedes the transition state in S_N2 reactions, including methyl transfer. Notably, the angles between the tetrel bond donor and acceptor atoms coincide with the prerequisite geometry for the S_N2 reaction. Prompted by these findings, we surveyed crystal structures of methyltransferases in the Protein Data Bank and discovered …

Pavela Leads Uab Team To Study Association Of Bmi And Mortality, Alicia Rohan

Browse All News

No abstract provided.

X-Search: An Open Access Interface For Cross-Cohort Exploration Of The National Sleep Research Resource, Licong Cui, Ningzhou Zeng, Matthew Kim, Remo Mueller, Emily Ruth Hankosky, Susan Redline, Guo-Qiang Zhang

Computer Science Faculty Publications

Background: The National Sleep Research Resource (NSRR) is a large-scale, openly shared, data repository of de-identified, highly curated clinical sleep data from multiple NIH-funded epidemiological studies. Although many data repositories allow users to browse their content, few support fine-grained, cross-cohort query and exploration at study-subject level. We introduce a cross-cohort query and exploration system, called X-search, to enable researchers to query patient cohort counts across a growing number of completed, NIH-funded studies in NSRR and explore the feasibility or likelihood of reusing the data for research studies.

Methods: X-search has been designed as a general framework with two loosely-coupled components: …

11-13-2018 Swosu Hosts Oklahoma Academy Of Science Meeting, Southwestern Oklahoma State University

THE BARK ARCHIVE 2018

Around 160 faculty and students from 18 institutions in Oklahoma, Arkansas and Texas recently attended the 107 annual technical meeting of the Oklahoma Academy of Science held on the Southwestern Oklahoma State University campus in Weatherford.

Effects Of Intraoperative Epidural Anesthesia During Hepatectomy On Intraoperative And Post-Operative Patient Outcomes, Christopher Mallard, Brad Withers, Brooke Bauer, Paul A. Sloan, Sean Dineen, Annette Rebel

Anesthesiology Faculty Publications

Objective: The objective of this study was to evaluate the effects of intraoperative epidural anesthesia combined with balanced general anesthesia on intraoperative hemodynamics and fluid requirement, and on postoperative patient outcome.

Design: The study design was a retrospective data analysis of patients undergoing open hepatectomy at a single tertiary care center from May, 2013 to June, 2016. Patients undergoing hepatectomies were separated into two groups: patients not receiving epidural local anesthetic intraoperatively (either no epidural or epidural catheter not used intraoperatively) were designated the control group and patients receiving epidural local anesthetic intraoperatively (bolus and/or continuously). Patients were excluded if …

The Current Volume 29 : Issue 14, Nova Southeastern University

Student Newspapers

No abstract provided.

An Enzyme In Immune Cells Plays Essential Role In Host Defense Against Tuberculosis, Staff

Browse All News

No abstract provided.

Meta-Analysis Challenges A Textbook Example Of Status Signalling And Demonstrates Publication Bias, Alfredo Sánchez-Tójar, Shinichi Nakagawa, Moisès Sánchez-Fortún, Dominic A. Martin, Sukanya Ramani, Antje Girndt, Veronika Bókony, Bart Kempenaers, András Liker, David F. Westneat, Terry Burke, Julia Schroeder

Biology Faculty Publications

The status signalling hypothesis aims to explain within-species variation in ornamentation by suggesting that some ornaments signal dominance status. Here, we use multilevel meta-analytic models to challenge the textbook example of this hypothesis, the black bib of male house sparrows (Passer domesticus). We conducted a systematic review, and obtained primary data from published and unpublished studies to test whether dominance rank is positively associated with bib size across studies. Contrary to previous studies, the overall effect size (i.e. meta-analytic mean) was small and uncertain. Furthermore, we found several biases in the literature that further question the support available …

The Social Side Of "Borderline:" Edgework In The Narrative Accounts Of Self-Injurers, Victoria Lynn Gaines

Electronic Theses and Dissertations Archive

Eleven in-depth life history interviews with respondents who identified as former self-injurers and a thematic analysis of the existing qualitative literature on self-injury constitute the data for this research. Self-injury, a growing public health concern, has typically been framed by researchers as an individual level, psychological, phenomenon with largely negative connotations. Edgework, a theoretical orientation which has been used to explain voluntary risk-taking such as skydiving and mountain climbing, has been applied to the activity of self-injury. The interviews and qualitative research on self-injury were coded for the presence of edgework as a vocabulary of motive. Framed as edgework, this …

Optimization Of An Advanced Aerogel Packaging Solution For Cold-Chain Biological Materials Handling, Aaron Michael Cook

Electronic Theses and Dissertations Archive

The thermal performance of typical insulating materials is a limiting factor in the cost effectiveness of transporting temperature sensitive, biological materials, also known as cold chain bio-logistics. Biologicals that need to be maintained at near freezing or cryogenic temperatures rely on active refrigeration systems or passive solutions, such as dewars, gel packs, dry ice, urethane foam and/or extruded polystyrene. To ensure the packages arrive at its destination and at the desired temperature, costly overnight or expedited shipping is required. Hence, an aerogel based packaging solution is proposed as a possible solution for maintaining an acceptable internal temperature range with the …

Determination And Prediction Of Zinc Speciation In Estuaries, Holly B.C. Pearson, Sean D.W. Comber, Charlotte B. Braungardt, Paul Worsfold, Anthony Stockdale, Stephen Lofts

School of Geography, Earth and Environmental Sciences

Lowering of the estuarine Environmental Quality Standard for zinc in the UK to 121 nM reflects rising concern regarding zinc in ecosystems and is driving the need to better understand its fate and behavior and to develop and parametrize speciation models to predict the metal species present. For the first time, an extensive data set has been gathered for the speciation of zinc within an estuarine system with supporting physicochemical characterization, in particular dissolved organic carbon. WHAM/Model VII and Visual MINTEQ speciation models were used to simulate zinc speciation, using a combination of measured complexation variables and available defaults. Data …

John J. Kopchick Awards Support 15 Student And Faculty Research Projects (November 13, 2018), University Communications And Marketing

OHIO News Articles Archive

No abstract provided.

Completely Top–Down Hierarchical Structure In Quantum Mechanics, Yakir Aharonov, Eliahu Cohen, Jeff Tollaksen

Mathematics, Physics, and Computer Science Faculty Articles and Research

Can a large system be fully characterized using its subsystems via inductive reasoning? Is it possible to completely reduce the behavior of a complex system to the behavior of its simplest “atoms”? In this paper we answer these questions in the negative for a specific class of systems and measurements. After a general introduction of the topic, we present the main idea with a simple two-particle example, where strong correlations arise between two apparently empty boxes. This leads to surprising effects within atomic and electromagnetic systems. A general construction based on preand postselected ensembles is then suggested, wherein the Nbody …

Snare-Dependent Membrane Fusion Initiates Α-Granule Matrix Decondensation In Mouse Platelets, Irina D. Pokrovskaya, Smita Joshi, Michael Tobin, Rohan Desai, Maria A. Aronova, Jeffrey A. Kamykowski, Guofeng Zhang, Sidney W. Whiteheart, Richard D. Leapman, Brian Storrie

Molecular and Cellular Biochemistry Faculty Publications

Platelet α-granule cargo release is fundamental to both hemostasis and thrombosis. Granule matrix hydration is a key regulated step in this process, yet its mechanism is poorly understood. In endothelial cells, there is evidence for 2 modes of cargo release: a jack-in-the-box mechanism of hydration-dependent protein phase transitions and an actin-driven granule constriction/extrusion mechanism. The third alternative considered is a prefusion, channel-mediated granule swelling, analogous to the membrane “ballooning” seen in procoagulant platelets. Using thrombin-stimulated platelets from a set of secretion-deficient, soluble N-ethylmaleimide factor attachment protein receptor (SNARE) mutant mice and various ultrastructural approaches, we tested predictions of these …

Analysis Of Printed Electronic Adhesion, Electrical, Mechanical, And Thermal Performance For Resilient Hybrid Electronics, Clayton Neff

USF Tampa Graduate Theses and Dissertations

Today’s state of the art additive manufacturing (AM) systems have the ability to fabricate multi-material devices with novel capabilities that were previously constrained by traditional manufacturing. AM machines fuse or deposit material in an additive fashion only where necessary, thus unlocking advantages of mass customization, no part-specific tooling, near arbitrary geometric complexity, and reduced lead times and cost. The combination of conductive ink micro-dispensing AM process with hybrid manufacturing processes including: laser machining, CNC machining, and pick & place enables the fabrication of printed electronics. Printed electronics exploit the integration of AM with hybrid processes and allow embedded and/or conformal …

An Exploration Of The Quality Of Relationship Between Step-Children And Step-Parents Based On Address Term Usage, Sierra R. Payton

Theses and Dissertations

This study aimed to examine address term usage as a communicative component of blended/step-families by examining the address terms that step-children use to address their step-parent and whether address term usage can allude to the quality of relationship reported by step-children within the step-child step-parent relationship. Rowan University undergraduate students (n=67) were recruited to complete questionnaires on address term usage and quality of relationship using the Quality of Relationships Inventory (QRI). Address term usage was the independent variable and was measured using three levels: formal, familiar, and familial. Quality of relationship was the dependent variable and was measured using the …

Distinct Role Of Il-27 In Immature And Lps-Induced Mature Dendritic Cell-Mediated Development Of Cd4, Fang Zhou, Guang-Xian Zhang, A. M. Rostami

Department of Neurology Faculty Papers

Interleukin-27 (IL-27) plays an important role in regulation of anti-inflammatory responses and autoimmunity; however, the molecular mechanisms of IL-27 in modulation of immune tolerance and autoimmunity have not been fully elucidated. Dendritic cells (DCs) play a central role in regulating immune responses mediated by innate and adaptive immune systems, but regulatory mechanisms of DCs in CD4⁺ T cell-mediated immune responses have not yet been elucidated. Here we show that IL-27 treated mature DCs induced by LPS inhibit immune tolerance mediated by LPS-stimulated DCs. IL-27 treatment facilitates development of the CD4⁺ CD127⁺3G11⁺ regulatory T cell subset …

Myeloablative Vs Reduced-Intensity Conditioning Allogeneic Hematopoietic Cell Transplantation For Chronic Myeloid Leukemia, Saurabh Chhabra, Kwang Woo Ahn, Zhen-Huan Hu, Sandeep Jain, Amer Assal, Jan Cerny, Edward A. Copelan, Andrew Daly, Zachariah Defilipp, Shahinaz M Gadalla, Robert Peter Gale, Siddhartha Ganguly, Betty K. Hamilton, Gerhard C. Hildebrandt, Jack W. Hsu, Yoshihiro Inamoto, Abraham S. Kanate, H. Jean Khoury, Hillard M. Lazarus, Mark R. Litzow, Sunita Nathan, Richard F. Olsson, Attaphol Pawarode, Olle Ringden, Jacob M. Rowe, Ayman Saad, Bipin N. Savani, Harry C. Schouten, Sachiko Seo, Nirav N. Shah

Markey Cancer Center Faculty Publications

Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative treatment of chronic myeloid leukemia (CML). Optimal conditioning intensity for allo-HCT for CML in the era of tyrosine kinase inhibitors (TKIs) is unknown. Using the Center for International Blood and Marrow Transplant Research database, we sought to determine whether reduced-intensity/nonmyeloablative conditioning (RIC) allo-HCT and myeloablative conditioning (MAC) result in similar outcomes in CML patients. We evaluated 1395 CML allo-HCT recipients between the ages of 18 and 60 years. The disease status at transplant was divided into the following categories: chronic phase 1, chronic phase 2 or greater, and accelerated phase. Patients …

System And Methods For Ventilation Through A Body Cavity, Mark A. Borden, Benjamin S. Terry

Department of Mechanical and Materials Engineering: Faculty Publications

A system and methods for the delivery of oxygen through a body cavity of a subject using oxygen microbubbles . Through circulation of oxygen microbubbles through the body cavity , oxygen and carbon dioxide exchange may occur . Overall improvement in extending survival rate time during emergency situations caused by pulmonary or similar oxygen - intake restricting injury and / or failure may be achieved through use of the invented system and methods .

Hif Prolyl Hydroxylase Inhibition Protects Skeletal Muscle From Eccentric Contraction-Induced Injury, Andrew N Billin, Samuel E Honeycutt, Alan V Mcdougal, Jaclyn P Kerr, Zhe Chen, Johannes M Freudenberg, Deepak K Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S Geske, Frank Fang, Bert Yao, Richard V Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C Hinken, Alan J Russell

Research outputs 2014 to 2021

BACKGROUND: In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments. Hypoxia-inducible factors (HIFs) regulate gene transcription under conditions of low oxygen, and HIF target genes EPO and VEGF have been associated with muscle protection and repair. We tested the importance of HIF activation following skeletal muscle injury, in both a murine model and human volunteers, using prolyl hydroxylase inhibitors that stabilize and activate HIF.

METHODS: Using a mouse eccentric limb injury model, we characterized the protective effects …

Quantum Algorithms, Architecture, And Error Correction, Ciarán Ryan-Anderson

Physics & Astronomy ETDs

Quantum algorithms have the potential to provide exponential speedups over some of the best known classical algorithms. These speedups may enable quantum devices to solve currently intractable problems such as those in the fields of optimization, material science, chemistry, and biology. Thus, the realization of large-scale, reliable quantum-computers will likely have a significant impact on the world. For this reason, the focus of this dissertation is on the development of quantum-computing applications and robust, scalable quantum-architectures. I begin by presenting an overview of the language of quantum computation. I then, in joint work with Ojas Parekh, analyze the performance of …

The Art Of Research: A Divergent/Convergent Framework And Opportunities For Science-Based Approaches, Glory E. Aviña, Christian D. Schunn, Austin R. Silva, Travis L. Bauer, George W. Crabtree, Curtis M. Johnson, Toluwalogo Odumosu, S. Thomas Picraux, R. Keith Sawyer, Richard P. Schneider, Rickson Sun, Gregory J. Feist, Venkatesh Narayanamurti, Jeffrey Y. Tsao

Faculty Research, Scholarly, and Creative Activity

Applying science to the current art of producing engineering and research knowledge has proven difficult, in large part because of its seeming complexity. We posit that the microscopic processes underlying research are not so complex, but instead are iterative and interacting cycles of divergent (generation of ideas) and convergent (testing and selecting of ideas) thinking processes. This reductionist framework coherently organizes a wide range of previously disparate microscopic mechanisms which inhibit these processes. We give examples of such inhibitory mechanisms and discuss how deeper scientific understanding of these mechanisms might lead to dis-inhibitory interventions for individuals, networks and institutional levels.

Investigating The Role Of The Rna Binding Protein Lin28 In The Human Placenta: Implications For Preeclampsia, John Canfield

USF Tampa Graduate Theses and Dissertations

An essential event during early pregnancy is the invasion of trophoblasts into the maternal decidua, which is necessary for proper implantation and establishment of maternal-fetal interface and ultimately allows for proper nutrient exchange and immunological tolerance of the growing fetus. For this invasion to occur, cells originating from the trophectoderm undergo an epithelial to mesenchymal transition to become invasive extravillous trophoblasts and begin invading the uterine decidual tissue. Through the secretion of matrix metalloproteinases and through interactions with many cytokines and cell-adhesion molecules, this well-orchestrated process of trophoblast invasion results in extensive remodeling of the maternal spiral vasculature by the …

Investigation Of Anemarrhena Asphodeloides And Its Constituent Timosaponin-Aiii As Novel, Naturally Derived Adjunctive Therapeutics For The Treatment Of Advanced Pancreatic Cancer, Catherine B. Marelia

USF Tampa Graduate Theses and Dissertations

Pancreatic adenocarcinoma (PDAC) remains one of the most lethal cancer types, with 92% of patients succumbing to the disease within five years. One of the hallmarks of this intractable disease is its nearly universal resistance to chemotherapeutic intervention. The deoxycytidine analog gemcitabine persists as the primary chemotherapy for advanced PDAC patients despite little improvement to its toxicity and tenuous efficacy over the past two decades. Plant-based drug discovery has a longstanding history and has led to some of the most significant drugs of the modern era, including some chemotherapeutic agents like paclitaxel and camptothecin. Our study analyzed the potential inhibitory …

Computationally-Enhanced Ecologies, Organisms, And Parasites. Speculative Explorations Of Symbiotic Oscillations, S Didakis

School of Art, Design and Architecture

This paper presents theoretical and practical research related to computationally-enhanced environments, analysing speculative explorations of media technologies that extend our understanding on alternative modes of architectural realities. An analysis is made concerning this transformation of interior spaces that realise immaterial dimensions and hidden layers of information, demonstrating strategies for computationally-enhanced ecologies that become an essential organism of the functions and aesthetics of space. The case studies presented in this work attempt to focus on how technological development and cutting-edge media practices are utilized to create objects and systems within the physical space for augmenting and amplifying creative processes, and exploring …

Teaching Differential Equations Without Computer Graphics Solutions Is A Crime, Beverly H. West

CODEE Journal

In the early 1980s computer graphics revolutionized the teaching of ordinary differential equations (ODEs). Yet the movement to teach and learn the qualitative methods that interactive graphics affords seems to have lost momentum. There still exist college courses, even at big universities, being taught without the immense power that computer graphics has brought to differential equations. The vast majority of ODEs that arise in mathematical models are nonlinear, and linearization only approximates solutions sufficiently near an equilibrium. Introductory courses need to include nonlinear DEs. Graphs of phase plane trajectories and time series solutions allow one to see and analyze the …

Evaluation Of Proton Therapy Accuracy Using A Pmma Phantom And Pet Prediction Module, Wen Hsi

All Publications

Purpose: Positron emission tomography (PET) scanning is a widely used method of proton therapy verification. In this study, a proton radiotherapy accuracy verification process was developed by comparing predicted and measured PET data to verify the correctness of PET prediction and was tested at the Shanghai Proton and Heavy Ion Center.

Method: Irradiation was performed on a polymethyl methacrylate (PMMA) phantom. There were two dose groups, to which 2 and 4 Gy doses were delivered, and each dose group had different designed dose depths ranging from 5 to 20 cm. The predicted PET results were obtained using a PET prediction …

Lindenwood Digest, November 13, 2018, Lindenwood University

Lindenwood Digest

The Lindenwood Digest has been a digital employee newsletter since 2009.