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2018

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The Role Of Apoptosis And The Effect Of Epidermal Growth Factor On Proapoptotic Bnip 3 In An Experimental Rat Priapism Model, Osman Barut, Ahmet Karakeçi̇, Tunç Ozan, Fati̇h Firdolaş, Neci̇p Pi̇ri̇nççi̇, İrfan Orhan Jan 2018

The Role Of Apoptosis And The Effect Of Epidermal Growth Factor On Proapoptotic Bnip 3 In An Experimental Rat Priapism Model, Osman Barut, Ahmet Karakeçi̇, Tunç Ozan, Fati̇h Firdolaş, Neci̇p Pi̇ri̇nççi̇, İrfan Orhan

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the effects of apoptosis-inducing Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP 3) and antiapoptotic epidermal growth factor (EGF) on the pathophysiology of experimental low-flow priapism. Materials and methods: Twenty-four adult Sprague-Dawley rats were divided into four equal groups. Group I was the control group. Ischemic priapism was induced for 4 h in Group II rats. In Group III, intraperitoneal EGF at 10 µg/kg was given for 7 days before induction of ischemic priapism for 4 h. In Group IV, intraperitoneal EGF at 20 µg/kg was given for 7 days before induction of ischemic priapism …

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Is Thermal Balloon Ablation In Women With Previous Cesarean Delivery Successful?, Zinatossadat Bouzari, Shahla Yazdani, Mojgan Naeimi Rad, Ali Bijani Jan 2018

Is Thermal Balloon Ablation In Women With Previous Cesarean Delivery Successful?, Zinatossadat Bouzari, Shahla Yazdani, Mojgan Naeimi Rad, Ali Bijani

Turkish Journal of Medical Sciences

Background/aim: Endometrial ablation is used to treat heavy menstrual bleeding in women who do not respond to standard therapy. is study aimed to compare treatment success in women with previous cesarean delivery and vaginal delivery who were subjected to thermal balloon ablation. Materials and methods: This cohort study enrolled women with symptoms of heavy menstrual bleeding who had major health problems and were considered as high-risk patients for hysterectomy. Patients were divided into two groups, vaginal delivery and cesarean section (C-section). ermal balloon ablation was performed under general or regional anesthesia on days 3?5 of the menstrual cycle. Treatment success …

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Low Levels Of Vitamin D Are Associated With Nosocomial Infections But Not With Short-Term Mortality In Critically Ill Patients, Işil Köse Güldoğan, Çi̇ler Zi̇nci̇rci̇oğlu, Hüseyi̇n Özkarakaş, Meltem Çakmak, Gürsel Ersan, Lütfi̇ye Kuzucu, Şükran Köse, Ni̇met Şenoğlu Jan 2018

Low Levels Of Vitamin D Are Associated With Nosocomial Infections But Not With Short-Term Mortality In Critically Ill Patients, Işil Köse Güldoğan, Çi̇ler Zi̇nci̇rci̇oğlu, Hüseyi̇n Özkarakaş, Meltem Çakmak, Gürsel Ersan, Lütfi̇ye Kuzucu, Şükran Köse, Ni̇met Şenoğlu

Turkish Journal of Medical Sciences

Background/aim: A prospective observational study was conducted to determine the relationship between vitamin D de ciency and nosocomial infections among intensive care unit (ICU) patients. Materials and methods: Demographic data, season of admission, vitamin D levels at admission, premorbid lifestyle scores, comorbid conditions, and admission diagnosis were recorded in 306 ICU patients. Infections that developed at least 48 h a er admission to the ICU were the primary outcome, and ICU, hospital, and 1-year mortality were the secondary outcomes. Infections were evaluated for 28 days, and for the entire duration of ICU stay independently. Multiple logistic regression analysis was performed …

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Effect Of Mometasone Furoate Nasal Spray On The Dna Of Nasal Mucosal Cells, Hakan Akkaş, Erdi̇nç Aydin, Seda Türkoğlu Babakurban, Erkan Yurtcu, Özlem Yilmaz Özbek Jan 2018

Effect Of Mometasone Furoate Nasal Spray On The Dna Of Nasal Mucosal Cells, Hakan Akkaş, Erdi̇nç Aydin, Seda Türkoğlu Babakurban, Erkan Yurtcu, Özlem Yilmaz Özbek

Turkish Journal of Medical Sciences

Background/aim: Allergic rhinitis (AR) is a respiratory disease caused by in ammation of the nasal mucosa. Intranasal corticosteroids (ICs) are an e ective treatment for AR; however, their use has been associated with atrophy in nasal mucosae. Because DNA damage has been linked to several chronic diseases, we hypothesize that use of ICs could cause DNA damage in nasal mucosa cells, leading to mucosal atrophy and septal perforation. Materials and methods: Sixty patients with moderate or severe AR were divided randomly into two groups. Mometasone furoate (MF) and antihistamine tablets (desloratadine) were given to the study (IC) group. Physiologic saline …

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Why Humans Are Different, Tara Fox Hall Jan 2018

Why Humans Are Different, Tara Fox Hall

Animal Sentience

A central human problem is our inference from the fact that we are the world’s most intelligent species to the alleged fact that we are superior. This inference is not mandatory. Successfully combating this inference may require the threat of a large-scale catastrophe to our species.

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Two Fallacies In Comparisons Between Humans And Non-Humans, Don Ross Jan 2018

Two Fallacies In Comparisons Between Humans And Non-Humans, Don Ross

Animal Sentience

The hypothesis that humans are superior to non-humans by virtue of higher cognitive powers is often supported by two recurrent fallacies: (1) that any competence shown by humans but not by our closest living relatives (apes) must be unique to humans; and (2) that grades of intelligence can be inferred from behavior without regard to motivational structures.

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Comparison Between Iloprost And Alprostadil For Protection Againstischemia/Reperfusion Injury In A Rat Model, Deni̇z Çevi̇rme, Taylan Adademi̇r, Eylül Kafali Başaran, Ömer Faruk Şavluk, Ahmet Eli̇bol, Gözde Erkanli Şentürk, Hati̇ce Akkaya, Bayram Yilmaz Jan 2018

Comparison Between Iloprost And Alprostadil For Protection Againstischemia/Reperfusion Injury In A Rat Model, Deni̇z Çevi̇rme, Taylan Adademi̇r, Eylül Kafali Başaran, Ömer Faruk Şavluk, Ahmet Eli̇bol, Gözde Erkanli Şentürk, Hati̇ce Akkaya, Bayram Yilmaz

Turkish Journal of Medical Sciences

Background/aim: Alprostadil and iloprost are successful agents used for both pulmonary hypertension and extremity ischemia treatment. Different systemic effects of these agents may change the preferences of clinical usage. Superiority of preventing ischemia/ reperfusion (IR) injury is a criterion for clinical preference of these agents. The present study was designed to compare the protective effects of alprostadil and iloprost in a rat model of IR injury. Materials and methods: Twenty-three male Sprague Dawley rats were used (aged 8-12 weeks, mean weight 230 ± 30 g). They were randomized into 4 groups: Group 1 (iloprost + IR), Group 2 (alprostadil + …

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Investigation Of Phikz Phage Therapy Against Pseudomonas Aeruginosa In Mousepneumonia Model, Kübra Can, Uğur Aksu, Osman Şadi̇ Yenen Jan 2018

Investigation Of Phikz Phage Therapy Against Pseudomonas Aeruginosa In Mousepneumonia Model, Kübra Can, Uğur Aksu, Osman Şadi̇ Yenen

Turkish Journal of Medical Sciences

Background/aim: The aim of this study was to investigate the effects of PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the Pseudomonas aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined. Materials and methods: The systemic, lung-specific, and kidney-specific inflammation levels and the bacterial load in lung tissue and biochemical parameters were investigated after PhiKZ phage therapy and meropenem alone or combined treatments in a pneumonia mouse model induced by the P. aeruginosa PAO1 strain. The cross-talk between lungs and kidneys was also determined by measuring plasma levels of …

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Saliva Levels Of Caspase-1, Tnf-α, And Ifn-γ In Primary Sjögren's Syndrome: Oralmucosal Abnormalities Revisited, Gonca Karabulut, Gül Ki̇tapçioğlu, Özgün Özçaka, Esi̇n Alpöz, Ayşe Nalbantsoy, Hayri̇ye Koçanaoğullari, Sercan Gücenmez, Gökhan Keser, Yasemi̇n Kabasakal Jan 2018

Saliva Levels Of Caspase-1, Tnf-α, And Ifn-γ In Primary Sjögren's Syndrome: Oralmucosal Abnormalities Revisited, Gonca Karabulut, Gül Ki̇tapçioğlu, Özgün Özçaka, Esi̇n Alpöz, Ayşe Nalbantsoy, Hayri̇ye Koçanaoğullari, Sercan Gücenmez, Gökhan Keser, Yasemi̇n Kabasakal

Turkish Journal of Medical Sciences

Background/aim: Abnormalities in oral mucosal immunity contribute to complex pathogenesis of primary Sjögren's syndrome (pSjS). We aimed to measure saliva and serum levels of caspase-1, tumor necrosis factor-alpha (TNF-α) and interferon gamma (IFN-γ) in patients with pSjS. Materials and methods: We studied 43 pSjS patients fulfilling the AECG criteria and 30 age/sex-matched healthy controls, as well as 39 rheumatoid arthritis (RA) patients as a disease control group. ESSDAI scores were less than seven in all patients with pSjS, indicating low disease activity. Quantitative analyses were made in serum and whole saliva samples. The statistical analysis was performed using SPSS 19.0. …

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Positive Correlation Of Galanin With Insulin Resistance And Triglyceride Levels In Obesechildren, Sezer Acar, Ahu Paketçi̇, Tuncay Küme, Korcan Demi̇r, Özlem Gürsoy Çalan, Ece Böber, Ayhan Abaci Jan 2018

Positive Correlation Of Galanin With Insulin Resistance And Triglyceride Levels In Obesechildren, Sezer Acar, Ahu Paketçi̇, Tuncay Küme, Korcan Demi̇r, Özlem Gürsoy Çalan, Ece Böber, Ayhan Abaci

Turkish Journal of Medical Sciences

Background/aim: Galanin is a neuropeptide that is shown to be involved in the regulation of food intake and glucose homeostasis. The objective of this study was to evaluate the relation of serum galanin levels with anthropometric and metabolic parameters in obese and healthy children. Material and methods: The cross-sectional study consisted of 38 obese children (mean age: 11.9 ± 3.0 years) and 30 healthy children (mean age: 11.4 ± 2.0 years). Clinical and biochemical parameters [glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), lipids, galanin, and leptin levels] were assessed. Results: Serum galanin and leptin levels were significantly higher in obese …

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Exploring The Role Of Mirnas In The Diagnosis Of Mody3, Oğuzhan Fati̇h Baltaci, Şeyma Çolakoğlu, Gökçe Güllü Amuran, Nesli̇han Aydin, Mehmet Sarğin, Arzu Karabay Korkmaz, Mehmet Temel Yilmaz, Ergül Berber Jan 2018

Exploring The Role Of Mirnas In The Diagnosis Of Mody3, Oğuzhan Fati̇h Baltaci, Şeyma Çolakoğlu, Gökçe Güllü Amuran, Nesli̇han Aydin, Mehmet Sarğin, Arzu Karabay Korkmaz, Mehmet Temel Yilmaz, Ergül Berber

Turkish Journal of Medical Sciences

Background/aim: MODY3 associated with HNF1A is the most common form of MODY and is clinically misdiagnosed as type 1 diabetes due to similar clinical symptoms. This study aimed to analyze the role of HNF1A-regulated miRNAs as a biomarker in the diagnosis of MODY3. Materials and methods: MIN6 cells were transfected with the HNF1A cDNA expression vector for overexpression or with siRNA specific to HNF1A to silence its expression. The HNF1A-regulated miRNAs were determined by RNA-Seq of the total RNA extract. Expressions of the candidate miRNAs in blood samples of MODY3, type 1 diabetes, and type 2 diabetes patients and in …

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Se33 Locus As A Reliable Genetic Marker For Forensic Dna Analysis Systems, Dr Munir Ahmad Bhinder, Muhammad Yasir Zahoor, Haleema Sadia, Muhammad Qasim, Rukhsana Perveen, Ghulam Murtaza Anjum, Muhammad Iqbal, Najeeb Ullah, Waseem Shehzad, Muhammad Tariq, Ali Muhammad Waryah Jan 2018

Se33 Locus As A Reliable Genetic Marker For Forensic Dna Analysis Systems, Dr Munir Ahmad Bhinder, Muhammad Yasir Zahoor, Haleema Sadia, Muhammad Qasim, Rukhsana Perveen, Ghulam Murtaza Anjum, Muhammad Iqbal, Najeeb Ullah, Waseem Shehzad, Muhammad Tariq, Ali Muhammad Waryah

Turkish Journal of Medical Sciences

Background/aim: Genetic variation, an authentic tool of individual discrimination, is being used for forensic investigations worldwide. A missing result for even one out of 13-17 markers leads to an inconclusive report. Additional reliable markers are required to compensate such deficiencies. The SE33 locus has high genetic variability in different populations and is being used in forensic investigation systems in some countries. The purpose of the study was to assess the viability of use of the SE33 locus as a supportive marker for forensic DNA profiling. Materials and methods: Amplification of the SE33 locus was performed using the PowerPlex ES Monoplex …

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Existence Of Positive Periodic Solution Of Second-Order Neutral Differential Equations, Tuncay Candan Jan 2018

Existence Of Positive Periodic Solution Of Second-Order Neutral Differential Equations, Tuncay Candan

Turkish Journal of Mathematics

In this work, we consider two types of second-order neutral differential equations and we obtain sufficient conditions for the existence of positive $\om$-periodic solutions for these equations. We employ Krasnoselskii's fixed point theorem for the sum of a completely continuous and a contraction mapping. An example is included to illustrate our results.

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Modified Objective Function Approach For Multitime Variational Problems, Anurag Jayswal, Tadeusz Antczak, Shalini Jha Jan 2018

Modified Objective Function Approach For Multitime Variational Problems, Anurag Jayswal, Tadeusz Antczak, Shalini Jha

Turkish Journal of Mathematics

The present paper is devoted to studying the modified objective function approach used for solving the considered multitime variational problem. In this method, a new multitime variational problem is constructed by modifying the objective function in the original considered multitime variational problem. Further, the equivalence between an optimal solution to the original multitime variational problem and its associated modified problem is established under both hypotheses of invexity and generalized invexity defined for a multitime functional. Thereafter, using the modified objective function method, we derive the saddle-point results for the considered multitime variational problem. Moreover, we provide some examples to illustrate …

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Analysis Of Mixed-Order Caputo Fractional System With Nonlocal Integral Boundary Condition, Tuğba Akman Yildiz, Neda Khodabakhshi, Dumitru Baleanu Jan 2018

Analysis Of Mixed-Order Caputo Fractional System With Nonlocal Integral Boundary Condition, Tuğba Akman Yildiz, Neda Khodabakhshi, Dumitru Baleanu

Turkish Journal of Mathematics

This paper deals with a mixed-order Caputo fractional system with nonlocal integral boundary conditions. This study can be considered as an extension of previous studies, since the orders of the equations lie on different intervals. We discuss the existence and uniqueness of the solution using fixed point methods. We enrich the study with an example.

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Synthesis Of $E$-Stilbene Azomethines As Potent Antimicrobial And Antioxidant Agents, Ahsan Iqbal, Zulfiqar Ali Khan, Sohail Anjum Shahzad, Muhammad Usman, Shakeel Ahmad Khan, Abdul H. Fauq, Ayesha Bari, Muhammad Aamir Sajid Jan 2018

Synthesis Of $E$-Stilbene Azomethines As Potent Antimicrobial And Antioxidant Agents, Ahsan Iqbal, Zulfiqar Ali Khan, Sohail Anjum Shahzad, Muhammad Usman, Shakeel Ahmad Khan, Abdul H. Fauq, Ayesha Bari, Muhammad Aamir Sajid

Turkish Journal of Chemistry

A series of new extensively conjugated $E$-stilbene azomethines (5a-5h) were synthesized and screened for their antioxidant and antimicrobial activity. The compounds were tested against bacterial (Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Bacillus subtilis) and fungal strains (Aspergillus niger, A. flavus, and Trichoderma harzianum) using the agar well diffusion method. Among the tested compounds, $N$'-(4-nitrobenzylidene)-2-(($E)$-styryl)benzohydrazide (5g) was found to possess potent antimicrobial activity higher than some drugs with significant activity reported in the literature, e.g., cefradine and terbinafine hydrochloride. Additionally, compounds 5a-5h were also evaluated for antioxidant potential using DPPH free radical scavenging and ferric thiocyanate (FTC) assays. Among these, …

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An Efficient Water-Mediated Synthetic Route For The Alkylation Of Heteroarenes, Pinar Seyi̇tdanlioğlu, Essam Hamied Ahmed Hanashalhalshahaby, Canan Ünaleroğlu Jan 2018

An Efficient Water-Mediated Synthetic Route For The Alkylation Of Heteroarenes, Pinar Seyi̇tdanlioğlu, Essam Hamied Ahmed Hanashalhalshahaby, Canan Ünaleroğlu

Turkish Journal of Chemistry

An efficient synthetic route has been described for the alkylation of 1$H$-indole, 1$H$-benzimidazole, and 1$H$-benzotriazole. This approach features the alkylation of heteroaromatics through in situ generated enones from ketonic Mannich bases under metal-free conditions. A series of alkylated heteroaromatics have been synthesized via the K10 catalyzed alkylation reactions of these heteroaromatics with a variety of ketonic Mannich bases. Environmentally benign K10 catalyst, water-mediated mild reaction conditions, and the efficient synthesis of alkylated products are the advantages of this alkylation method.

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Determination Of Morin On An Electrochemically Activated Carbon-Paste Electrode, Alexander Chebotarev, Konstantin Pliuta, Denys Snigur Jan 2018

Determination Of Morin On An Electrochemically Activated Carbon-Paste Electrode, Alexander Chebotarev, Konstantin Pliuta, Denys Snigur

Turkish Journal of Chemistry

In this paper, the possibility of using an electrochemically activated carbon-paste electrode (ECA-CPE) for the determination of morin has been studied. It is established that the oxidation current increases 1.85 times in comparison with untreated CPE. The adsorption nature of the anodic current and the number of electrons taking part in the oxidation of morin on ECA-CPE was established. The optimal conditions for the determination of morin (pH $=$ 4, E$_{ads\, }=$ 200~mV, t$_{ads\, }=$ 180 s) were established. Using square-wave voltammetry (A $=$ 35 mV, $\nu =$ 25 Hz, $\upsilon =$ 100 mV/s) it is possible to determine morin …

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Synthesis, Spectroscopic Characterization, And Computational Studies Of 2-Cyano-6-Hydroxybenzothiazole: A Key Synthetic Intermediate Of Firefly Luciferin, Ghasem Shahmoradi, Saeid Amani Jan 2018

Synthesis, Spectroscopic Characterization, And Computational Studies Of 2-Cyano-6-Hydroxybenzothiazole: A Key Synthetic Intermediate Of Firefly Luciferin, Ghasem Shahmoradi, Saeid Amani

Turkish Journal of Chemistry

Firefly luciferin is widely applied as a biotechnological tool for visualizing various biological processes in vitro and in vivo. Chemically, 2-cyano-6-hydroxybenzothiazole, as a key synthetic intermediate of firefly luciferin, is obtained from 2-cyano-6-methoxybenzothiazole by changing the methoxy with a hydroxy group. However, this approach is costly and not suited for large-scale synthesis. Here we report cost-effective and efficient syntheses of 2-cyano-6-hydroxybenzothiazole through the catalytic Sandmeyer-type cyanation reaction. Our approach employs diazonium tetrafluoroborate salt of 2-amino-6-hydroxybenzothiazole as a cyanation substrate. The cyanation reaction proceeds efficiently under mild conditions by using Cu(I)/Cu(II)/N,N,N\textquotesingle,N\textquotesingle-tetramethylethylenediamine as a catalyst. In addition, computational studies of the 2-cyano-6-hydroxybenzothiazole …

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Effect Of Ph On The Complexation Of Irbesartan With $\Beta $-, Hydroxypropyl-$\Beta $-, And $\Gamma $-Cyclodextrin: Solubility Enhancement And Physicochemical Characterization, Fakhri Yousef Jan 2018

Effect Of Ph On The Complexation Of Irbesartan With $\Beta $-, Hydroxypropyl-$\Beta $-, And $\Gamma $-Cyclodextrin: Solubility Enhancement And Physicochemical Characterization, Fakhri Yousef

Turkish Journal of Chemistry

The affinity of irbesartan (IRB) to form inclusion complexes with $\beta $-cyclodextrin ($\beta $-CD), hydroxypropyl-$\beta $-cyclodextrin (HP-$\beta $-CD), and $\gamma $-cyclodextrin ($\gamma $-CD) was investigated in aqueous buffered solutions at pH 1.7, 4.1, and 7.0. Analysis of the UV absorption-pH profiles revealed that IRB has two p$K_{a}$ values: p$K_{a1\, }=$ 3.60 (imidazolinone ring moiety) and p$K_{a2\, }=$ 4.70 (tetrazole moiety). In the presence of 5.0 mmol L$^{-1} \beta $-CD, the tetrazole moiety became more acidic, indicating its inclusion within the $\beta $-CD cavity. Phase-solubility diagrams (PSDs) were obtained for IRB in aqueous buffered solutions of $\beta $-CD, HP-$\beta $-CD, and …

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Design And Synthesis Of New Naphtho[2,1-$B$]Pyrano [2,3-$D$]Pyrimidinones Under Classical And Microwave Conditions, Maher Cherif, Mariem Debbabi, Sarra Chortani, Anis Romdhane, Hichem Ben Jannet Jan 2018

Design And Synthesis Of New Naphtho[2,1-$B$]Pyrano [2,3-$D$]Pyrimidinones Under Classical And Microwave Conditions, Maher Cherif, Mariem Debbabi, Sarra Chortani, Anis Romdhane, Hichem Ben Jannet

Turkish Journal of Chemistry

A fast and efficient method for the synthesis of naphthopyranopyrimidinones derivatives in excellent yields was developed through cyclocondensation reaction between previously prepared pyrimidinic hydrazides and some electrophilic species such as 2,4-pentanedione, 2,5-hexanedione, cyclic anhydrides, and phenylthioisocyanate under microwave irradiation. Compared to the conventional methods applied, it was found that better yields and shorter reaction times were achieved using microwave-assisted synthesis. Structures of all synthesized compounds were established on the basis of spectroscopic methods including $^{1}$H NMR, $^{13}$C NMR, and HRMS-ES.

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Environmental Monitoring Report: For Work Performed: July 1, 2017 Through June 30, 2018, Tennessee. Department Of Environment And Conservation Jan 2018

Environmental Monitoring Report: For Work Performed: July 1, 2017 Through June 30, 2018, Tennessee. Department Of Environment And Conservation

Environmental Monitoring Reports

This FY2018 EMR presents the results of the 21 independent projects proposed in the FY2017 Environmental Monitoring Plan (EMP), and completed throughout FY2018. This monitoring report focuses on the following seven general areas: Radiological Monitoring, Biological Monitoring, Air Monitoring, Surface Water Monitoring, Sediment Monitoring, Groundwater Monitoring and RadNet.

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Creating A Lgbtq+ Inclusive Culture In The Athletic Training Facility, Sean M. Rogers, Ashley K. Crossway, Patricia A. Aronson Jan 2018

Creating A Lgbtq+ Inclusive Culture In The Athletic Training Facility, Sean M. Rogers, Ashley K. Crossway, Patricia A. Aronson

Clinical Practice in Athletic Training

No abstract provided.

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Makeup Changes The Apparent Size Of Facial Features, Alex L. Jones, Aurélie Porcheron, Richard Russell Jan 2018

Makeup Changes The Apparent Size Of Facial Features, Alex L. Jones, Aurélie Porcheron, Richard Russell

Psychology Faculty Publications

Makeup is a prominent example of the universal human practice of personal decoration. Many studies have shown that makeup makes the face appear more beautiful, but the visual cues mediating this effect are not well understood. A widespread belief holds that makeup makes the facial features appear larger. We tested this hypothesis using a novel reference comparison paradigm, in which carefully controlled photographs of faces with and without makeup were compared with an average reference face. Participants compared the relative size of specific features (eyebrows, eyes, nose, mouth) of the reference face and individual faces with or without makeup. Across …

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The Effect Of Downregulation Of A Cell-Wall Modigying Gene On Bud Set Timing In Populus Deltoides., Luke Jarrod Stover Jan 2018

The Effect Of Downregulation Of A Cell-Wall Modigying Gene On Bud Set Timing In Populus Deltoides., Luke Jarrod Stover

Capstones and Honors Theses

In an attempt to enhance the efficiency of biofuel production, research has traditionally focused on wood chemistry in forest trees. Altered wood chemistry has the potential to reduce recalcitrance to carbohydrate extraction and conversion, but may have unintended effects on dormancy. In Populus deltoides (eastern cottonwood), changes in dormancy may inhibit annual growth rates or put the trees at risk for frost damage, compromising benefits of genetic engineering. Genome wide association analysis indicates that multiple polymorphisms in and around the Potri.013G001600.1 gene of unknown function have a strong association with bud set date. This experiment isolated the gene's transcription levels …

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Crispr-Cas9 Mediated Genetic Ablation On The Actin Regulatory Protien Cortactin Does Not Impain Hnscc Invasive Processes, River Austin Hames Jan 2018

Crispr-Cas9 Mediated Genetic Ablation On The Actin Regulatory Protien Cortactin Does Not Impain Hnscc Invasive Processes, River Austin Hames

Capstones and Honors Theses

Head and neck squamous cell carcinoma (HNSCC) is a highly invasive cancer with a five-year overall survival of approximately 50%. HNSCC incidence is increasing in WV and other Appalachian areas due to high tobacco consumption and human papilloma virus exposure. Genomic instability is a hallmark of tobacco carcinogen exposure, resulting in amplification of chromosomal region 11q13 in 25% of all HNSCC cases. 11q13 amplification correlates with poorer prognosis and increased tumor aggressiveness. The CTTN locus resides in the 11q13 amplicon and encodes the actin-regulatory protein cortactin. Increased cortactin expression resultant from CTTN amplification drives HNSCC invasiveness by increasing tumor cell …

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Richard Smalley And The Materials Of Tomorrow: The Discovery And Science Of Fullerenes, Creighton A. Jackson Jan 2018

Richard Smalley And The Materials Of Tomorrow: The Discovery And Science Of Fullerenes, Creighton A. Jackson

Natural Sciences Student Research Presentations

This poster for the Natural Sciences Poster Session at Parkland College details the contributions of Richard Smalley to organic chemistry, specifically the discovery of fullerenes in 1984, which led to advancements in the field of nanoscience. Fullerene use in materials science, Single-walled and multi-walled nanotubes and use of fullerenes in biology are also outlined.

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Understanding Ttp, Alexis L. Koester Jan 2018

Understanding Ttp, Alexis L. Koester

Natural Sciences Student Research Presentations

This poster for the Natural Sciences Poster Session summarizes Thrombotic thrombocytopenic purpura (TTP), a rare autoimmune disorder, either inherited or acquired, that produces antibodies affecting the gene ADAMTS13, which causes bleeding and inhibits blood clotting. Symptoms include purple bruising (purpura) and small red dots on the skin, called petechiae. Untreated TTP can lead to damage in the brain, heart and kidneys.

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Richard Smalley And The Materials Of Tomorrow: The Discovery, Properties, And Science Of Fullerenes, Creighton A. Jackson Jan 2018

Richard Smalley And The Materials Of Tomorrow: The Discovery, Properties, And Science Of Fullerenes, Creighton A. Jackson

Natural Sciences Student Research Presentations

These are slides accompanying a presentation given at the Natural Sciences Poster Session at Parkland College outlining the properties of and ongoing research pertaining to fullerenes in materials science.

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Chemotaxis Assay: Analysis Of C. Elegans And Its Relationship With Various Microbial Agents, Alexander C. Wen Jan 2018

Chemotaxis Assay: Analysis Of C. Elegans And Its Relationship With Various Microbial Agents, Alexander C. Wen

Natural Sciences Student Research Presentations

This poster for the Natural Sciences Poster Session at Parkland College reports on an experiment in which the student seeks to find whether Caenorhabditis elegans (C.elegans) prefers OP50 strain of E.coli bacteria cultured in NGM agar. The experiment indicated that C. elegans showed a preference for the K12 strain of E.coli.

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