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Biological Study On Novel Coumarinyl 1,3,4-Oxadiazoles, Maja Molnar, Ana Amic, Valentina Pavic, Tihomir Kovac, Marija Kovac, Elizabeta Has-Schön

Turkish Journal of Chemistry

Coumarinyl 1,3,4-oxadiazoles were synthesized from Schiff bases and acetic anhydride. All compounds were characterized by melting points and their structures confirmed by mass and $^{1}$H and $^{13}$C NMR spectrometry. These novel coumarinyl derivatives were subjected to antibacterial, antifungal, anta atoxigenic, and antioxidant activity. Their activity varied depending on their structure, where 2-(3-acetyl-5-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)- 2,3-dihydro-1,3,4-oxadiazol-2-yl)-1,4-phenylene diacetate showed significant antioxidant and antibacterial activity on B. subtilis. 4-(3-Acetyl-5-(((4-methyl-2-oxo-2H-chromen-7-yl)oxy)methyl)-2,3-dihydro-1,3,4-oxadiazol-2-yl)-1,2-phenylene diacetate was found to possess excellent antifungal and antia atoxigenic activity.

The Synthesis Of New Oxindoles As Analogs Of Natural Product 3,3$^\Prime $-Bis(Indolyl)Oxindole And In Vitro Evaluation Of The Enzyme Activity Of G6pd And 6pgd, Si̇nan Bayindir, Adnan Ayna, Yusuf Temel, Mehmet Çi̇ftci̇

Turkish Journal of Chemistry

Natural and synthetic derivatives that contain an indole core are being used in medical treatments and technological processes. Therefore, the development of new synthetic methods for the synthesis of indole derivatives is very popular. In this study, new oxindoles with reaction of 4,7-dihydro-1$H$-indole (2) and isatin (4) were synthesized as analogs of natural product 3,3$^\prime $-bis(indolyl)oxindole. The biological properties of the compounds obtained during this study were also studied, showing that compounds 5, 7, and 12 inhibited the activity of G6PD with an IC$_{50}$ of 99 $\mu $M, 231 $\mu $M, and 304 $\mu $M respectively. The activity of rat …

Development Of A Molecularly Imprinted Polymer-Based Electrochemical Sensor For Tyrosinase, Aysu Yarman

Turkish Journal of Chemistry

For the first time a molecularly imprinted polymer (MIP)-based sensor for tyrosinase is described. This sensor is based on the electropolymerization of scopoletin or o-phenylenediamine in the presence of tyrosinase from mushrooms, which has a high homology to the human enzyme. The template was removed either by treatment with proteinase K or by alkaline treatment. The measuring signal was generated either by measuring the formation of a product by the target enzyme or by evaluation of the permeability of the redox marker ferricyanide. The o-phenylenediamine-based MIP sensor has a linear measuring range up to 50 nM of tyrosinase with a …

Protein Ion-Exchange Chromatography On A Biomacromolecule-Immobilized Monolithic Cryogel, Ahmet Eren Özkan, Idris Guven, Orhan Gezici

Turkish Journal of Chemistry

An efficient and inexpensive monolithic stationary phase (PHEMA-HA) has been prepared through an easy process comprising addition of humic acid (HA) to a mixture of 2-hydroxyethyl methacrylate (HEMA) and N,N'-methylenebisacrylamide (MBAAm) and subsequent radical-polymerization at -20 $^{\circ}$C. The prepared monolithic material was characterized in terms of various techniques and methods such as elemental analysis, FTIR spectroscopy, scanning electron microscopy, mercury porosimetry, hydrolytic stability tests, pH$_{pzc}$ measurements, water-holding capacity, and water permeability. The amount of HA incorporated into the structure was calculated as 45 mg/g from the elemental analysis results. The study was conceptualized on the basis of protein ion-exchange chromatography, …

Nickel(Ii)-Pph$_{3}$ Complexes With Ons And Onn Chelating Thiosemicarbazones: Synthesis And Inhibition Potential On Influenza A Viruses, Şükri̇ye Güveli̇, Kadi̇r Turan, Bahri̇ Ülküseven

Turkish Journal of Chemistry

Tetra-coordinated nickel(II) complexes of two ONS (1, \2) and seven ONN (3a-3g) chelating 2-hydroxy-3-methoxy-benzaldehyde thiosemicarbazones were synthesized. The dibasic ligands and complexes bearing PPh$_{3}$ as a coligand were characterized by means of analytical and spectroscopic data. Cytotoxic activities of the ligands and nickel(II) complexes were determined using the MTT assay in vitro against MDCK cells, and then all the compounds were tested on influenza virus replication by plaque assays. The compounds showed GI$_{50}$ values varying from concentrations of 15.9 up to 161.8 $\mu$ g/mL for MDCK cells. The plaque assays indicated that one ONS (1) and two ONN (3c and …

Synthesis, Biological Evaluation, And In Silico Study Of Some Unique Multifunctional 1,2,4-Triazole Acetamides, Almas Sattar, Aziz Ur Rehman, Muhammad Athar Abbasi, Sabahat Zahra Saddiqui, Shahid Rasool, Hira Khalid, Muhammad Arif Lodhi, Farman Ali Khan

Turkish Journal of Chemistry

The imperative demand for antibacterial agents and enzyme inhibitors prompted us to synthesize some new compounds, 6a-6k, bearing multifunctional moieties. The target acetamides were derived from 4-phenyl-5-(1-tosylpiperidin-4-yl)-4$H$-1,2,4-triazole-3-thiol (3). The structural analysis was carried out using modern spectroscopic techniques including IR, NMR, and EIMS spectral analysis. The antibacterial activity was screened against five bacterial strains including three gram-negative and two gram-positive ones. Enzyme inhibition was carried out against lipoxygenase enzyme and results were supported by in silico study. The synthesized compounds were proved to be potent antibacterial agents and enzyme inhibitors.

Synthesis And Biological Evaluation Of Novel Chalcones Bearing Morpholine Moiety As Antiproliferative Agents, Bedri̇ye Seda Kurşun Aktar, Emi̇ne Elçi̇n Oruç-Emre, İbrahi̇m Demi̇rtaş, Ayşe Şahi̇n Yağlioğlu, Ayşegül Karaküçük İyi̇doğan, Çağlar Güler, Şevki̇ Adem

Turkish Journal of Chemistry

In this research, a new series of ($E)$-3-(4-substitutedphenyl)-1-(4'-morpholinophenyl)prop-2-en-1-one derivatives 1-7 was synthesized, aiming to develop effective antiproliferative agents. The antiproliferative activities of compounds 1-7 were examined against HeLa and C6 cell lines at eight different concentrations using the BrdU ELISA assay. The activity results were compared with reference anticancer drug 5-fluorouracil (5-FU). Compound 1 had almost the same antiproliferative activity as 5-FU. Compounds 1-7 were found to have greater effects against the C6 cell line than the HeLa cell line. These compounds were also tested in order to determine their effects on enzyme activities. Compounds 2 and 3 exhibited strong …

Multiwall Carbon Nanotube Paste Electrode As A Sensor For Sensitive Determination Of Deferasirox In The Presence Of Uric Acid: Application For The Analysis Of Pharmaceutical And Biological Samples, Golnaz Parvizi Fard, Reza Emamali Sabzi

Turkish Journal of Chemistry

In this work, the electrochemical oxidation of deferasirox at a multiwall carbon nanotube paste electrode (MWCNTPE) was described. The electrochemical behavior of deferasirox was studied using cyclic voltammetry and chronoamperometry techniques and parameters such as charge transfer coefficient ($\alpha )$, the number of electrons involved in the rate-determining step ($n_{a})$, and diffusion coefficient ($D)$ were calculated. The capability of the electrode for the determination of deferasirox at low concentrations was investigated using the differential pulse voltammetry technique. It was found that the calibration graph of deferasirox was linear in the concentration range of 0.16-16.5 $\mu $M and its detection limit …

Biological Evaluation And Synthesis Of New Pyrimidine-2(1h)-Ol/-Thiol Derivatives Derived From Chalcones Using The Solid Phase Microwave Method, Seda Fandakli, Nuran Kahri̇man, Tayyi̇be Beyza Yücel, Şengül Alpay Karaoğlu, Nuretti̇n Yayli

Turkish Journal of Chemistry

Twenty-five new hydroxy- and methoxy-substituted 4,6-diarylpyrimidin-2(1H)-ol (20-34) and 4,6-diarylpyri\-midine-2(1H)-thiol derivatives (35-44) were synthesized from the reaction of the corresponding 1,3-diaryl-2-propene-1-one compounds (1-19) with urea or thiourea using the solid-phase microwave method. All the new synthetic compounds (20-44) were evaluated with regard to their $\alpha $-glucosidase activity. However, only compounds 22-25, 27,31,34, 35,37, and 40 exhibited a greater inhibitory effect than standard acarbose. The IC$_{50}$ values of the active compounds ranged between 2.36 and 13.34 $\mu $M. The 25 new compounds were also screened for their in vitro pancreatic lipase activity and compounds 20-27and 35-39 were found to be active. Of …

Recent Advances In Organ-On-A-Chip Technologies And Future Challenges: A Review, Hüseyi̇n Avci, Fatma Doğan Güzel, Sali̇m Erol, Ali̇ Akpek

Turkish Journal of Chemistry

The significant development in the construction of microscale cell culture platforms and the interest in bioanalytical analysis have recently resulted in the emergence of a new concept of `organ-on-a-chip' systems. Organ-on-a-chip is a new three-dimensional (3D) in vitro microfabricated unit that contains a multichannel microfluidic cell culture. Even if many informative and useful data are obtained from animal models and in vitro assays, they are still limited for extrapolation to human systems during drug design and development. Only about 1 out of 10,000 compounds is processed in clinical trials for final approval. As being the first example of its kind, …

Schiff Base Of Isoniazid And Ketoprofen: Synthesis, X-Ray Crystallographic, Spectroscopic, Antioxidant, And Computational Studies, Naima Rehman, Muhammad Khalid, Moazzam Hussain Bhatti, Uzma Yunus, Ataualpa Albert Carmo Braga, Faiz Ahmed, Syed Muddassir Ali Mashhadi, Muhammad Nawaz Tahir

Turkish Journal of Chemistry

Ketoprofen and isoniazid together are a potential combination of a nonsteroidal antiinflammatory drug and an antitubercular medicine to treat tuberculosis and associated symptoms like fever and fatigue. The Schiff base of isoniazid with ketoprofen is synthesized in this research. Infrared spectroscopy (IR) and X-ray diffraction (XRD) analysis of the crystal packing proved the formation of the Schiff base and the existence of N-H$\cdot \cdot \cdot $O hydrogen bonds between the hydrogen-bonded dimer of the Schiff base. The complete geometrical optimization of the monomer and hydrogen-bonded dimer of the Schiff base is performed utilizing M06-2X/6-31G(d,p) level theory and compared with the …

$S$-Substituted Derivatives Of 1,2,4-Triazol-3-Thiol As New Drug Candidates For Type Ii Diabetes, Aziz Ur Rehman, Khadija Nafeesa, Muhammad Athar Abbasi, Sabahat Zahra Saddiqui, Shahid Rasool, Syed Adnan Ali Shah, Muhammad Ashraf, Muhammad Arif Lodhi, Farman Ali Khan, Bakht Jahan

Turkish Journal of Chemistry

The therapeutic applications of 1,2,4-triazoles motivated us to synthesize some new derivatives. Two series of $S$-substituted derivatives (8a-8j, 12a-12i) of 5-$\{$1-[(4-chlorophenyl)sulfonyl]-3-piperidinyl$\}$-4-phenyl-4$H$-1,2,4-triazol-3-thiol (6) have been synthesized and evaluated for their biological potential. Using 4-chlorobenzene sulfonyl chloride (1) and ethyl piperidine-3-carboxylate (2), ethyl 1-[(4-chlorophenyl)sulfonyl]piperidine-3-carboxylate (3) was synthesized and converted into 3,4,5-trisubstituted 1,2,4-triazole (6) through formation of the corresponding carbohydrazide (4) and hydrazinecarbothioamide (5). Compound 6 was transformed into 8a-8j by alkyl halides (7a-7j) and into 12a-12i by $N$-aralkyl/aryl-2-bromoacetamides (11a-11i) in an aprotic solvent. The electrophiles, 11a-11i, were synthesized by gearing up $N$-substituted aralkyl/aryl amines (10a-10i) with 2-bromoacetyl bromide (9) under dynamic pH …

Synthesis Of Some Ketones Via Nano-Nickel Oxide Catalyzed Acylation Of Arylzinc Reagents; Strategy Involving The Use Of Mixed (Methyl)(Aryl)Zincs, Özgen Ömür Pekel, Ender Erdi̇k, Meli̇ke Kalkan

Turkish Journal of Chemistry

Nano-NiO catalyzed acylation of mixed (methyl)(aryl)zincs with aromatic acyl halides in THF at room temperature provides a new facile route for aryl-aroyl coupling. Among NiCl$_{2}$.L$_{2}$ and NiCl$_{2}$.L (L = monodentate and bidentate phosphine ligand) catalysts, the lower catalyst loading of NiCl$_{2}$ (dppf) may seem attractive; however, nano-NiO, being the lowest cost catalyst, is more favorable for aroylation of (methyl)(aryl)zincs. This procedure also provides a supplement to Cu and Pd catalyzed acylation of diorganozincs.

Synthesis And Characterizations Of Novel Thiazolyl-Thiadiazole Derivatives As Telomerase Activators, İsmai̇l Kayaği̇l, Ayşe Gül Mutlu, Ülkü Bayhan, İnanç Yilmaz, Şeref Demi̇rayak

Turkish Journal of Chemistry

Pyridine-3/4-thiocarboxamide derivatives were used as starting materials for the synthesis of the target compounds. The pyridine-3/4-thiocarboxamide derivatives were reacted with ethyl 2-chloroacetoacetate in ethanol to give the thiazole derivatives (1, 2). The two ethyl thiazole-carboxylate derivatives (1, 2) thus obtained were treated with sodium hydroxide solution and ethanol and converted to carboxylic acids (3, 4). The carboxylic acid derivatives (3, 4) were reacted with thiosemicarbazide in phosphoroxy trichloride and aminothiadiazole rings (5, 6) were formed. Thus, two thiazolyl-thiadiazole amine derivatives (5, 6) were obtained. These two derivatives (5, 6) were converted into two chloroacetamidothiadiazole derivatives (7, 8) by reaction with …

Synthesis, Solvatochromism, And Biological Activity Of Novel Azo Dyes Bearing 2-Pyridone And Benzimidazole Moieties, Dusan Mijin, Biljana Bozic Nedeljkovic, Bojan Bozic, Ilijana Kovrlija, Jelena Ladarevic, Gordana Uscumlic

Turkish Journal of Chemistry

New azo dyes bearing 2-pyridone and benzimidazole moieties were prepared using diazotization of 4-(1H-benzo[d]imidazol-2-yl)aniline and coupling of the obtained diazonium salt with substituted 3-cyano-2-pyridones. Obtained compounds were characterized via UV-Vis, FT-IR, and $^{1}$H and $^{13}$C NMR spectroscopy as well as by elemental analysis data. The UV-Vis spectra of the synthesized dyes were measured in thirteen solvents of different properties at room temperature. Solvatochromism and tautomerism of novel azo dyes were discussed. An MTT (3,4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide) test was performed to prove the biocompatibility of the investigated dyes. The investigated dyes exhibited satisfying antiproliferative activities against both tumor cell lines, MDA-MB-231 …

Synthesis Of Novel Sn38-Aspirin Prodrugs For The Treatment Of Hepatocellular Carcinoma, Zhimin Chen, Yi Luo, Aiping Fang, Chen Fan, Chenjuan Zeng

Turkish Journal of Chemistry

Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is a leading cause of cancer-related death worldwide. However, there is no effective chemotherapeutic treatment for HCC and its prognosis remains poor. Consequently, it is urgent to find an efficient antitumor agent to treat HCC. In this study, 7-ethyl-10-hydroxycamptothecin (SN38), the bioactive metabolite of the anticancer drug irinotecan (CPT-11), which is 100-1000 times more potent than CPT-11, was coupled with aspirin to give 4 prodrugs. Their structures were characterized by $^{1}$H~NMR and elemental analysis. The in vitro anticancer activities of these compounds on two human hepatocellular carcinoma cell lines …

A Novel One-Pot And Rapid Synthesis Of Polyfunctionalized Benzo[A]Pyrimido[5',4':5,6] Pyrido[2,3-C]Phenazine Derivatives Under Microwave Irradiation, Mahdieh Tabibian, Razieh Mohebat, Masoumeh Tabatabaee

Turkish Journal of Chemistry

A one-pot, environmentally friendly, and efficient protocol for the synthesis of novel polyfunctionalized benzo[$a$]pyrimido[5',4':5,6]pyrido[2,3-$c$]phenazine derivatives has been reported by a one-pot, four-component sequential reaction between 2-hydroxynaphthalene-1,4-dione, benzene-1,2-diamines, benzaldehydes, and 6-amino-1,3-dimethyluracil in the presence of $p$-TSA as a nontoxic, inexpensive, ecofriendly, and efficacious solid acid catalyst. Two C-C bonds, two C=N bonds, and one C-N bond, as well as two new rings, were formed in this reaction. Through this procedure, compounds with substantial biological and pharmaceutical properties are generated in a single operation. Factors such as high yields, less reaction time, operational simplicity, and lack of any dangerous reagents/solvents have made …

A Rapid And Sensitive Spectrofluorometric Method For The Determination Of Au(Iii) Based On Fluorescence Quenching Of A 1,3,5-Triphenyl-2-Pyrazoline, Aysel Başoğlu, Ümmühan Ocak, Seda Fandakli, Nuretti̇n Yayli

Turkish Journal of Chemistry

A simple, rapid, sensitive, and low-cost spectrofluorometric method was developed for the determination of Au(III) using 5-(2,3-dimethoxyphenyl)-3-(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole (L) in ethanol/water. The method is based on the change in the fluorescence intensity at 464 nm after excitation at 355 nm as a result of the reaction between the ligand and Au(III). The fluorescent emission of ligand at 464 nm decreased with the increasing of Au(III) concentration. The ligand concentration, pH effect, response time, and effect of foreign ions were determined. From the results of fluorescence titration experiments, it was found that the ligand (1 $\times $ 10$^{-7}$ M) was selective and …

Development Of A Nanoscale-Based Optical Chemical Sensor For The Detection Of No Radical, Özlem Öter, Aki̇f Ci̇han Aydin, Merve Zeyrek Ongun, Erdal Çeli̇k

Turkish Journal of Chemistry

Nitric oxide is one of the most important biochemical parameters in biological processes; it is also known as carcinogenic. There is need for the design of stable and durable solid phase nitric oxide sensors. In this study, we immobilized the nitric oxide sensitive molecules pyrene, tris(2,2'-bipyrdyl)dichlororuthenium(II) hexahydrate (Ru(bipy)$_{3}^{2+})$, and magnesium phthalocyanine (Mg-Pc) for the first time in polymeric or glassy matrices. We applied silver nanoparticles and ionic liquids in the fabrication process of polymeric electrospun fibers and thin films. We compared their NO sensitivity in micelle solutions that mimic the cell medium by both steady state and lifetime-based fluorescence measurements. …

Synthesis, Molecular Docking, And Pharmacological Evaluation Of Halobenzodithiophene Derivatives Against Alpha-Glucosidase, Urease, And Free Radical Production, Ghulam Abbas, Zahid Hassan, Ahmed Al-Harrasi, Syed Aun Muhammad, Ahood Juma Al-Quraini1, Zahra Khamis Al-Maani1, Ahmed Mohammed Al-Adawai

Turkish Journal of Chemistry

Benzodithiophenes are heterocyclic compounds that have various medicinal and industrial applications. In the present study, halobenzodithiophene, the simplest benzofused thiophene, and its derivatives were synthesized and evaluated against alpha-glucosidase, urease, and free radical production. In the alpha-glucosidase inhibition assay, compound 2,2-bisbenzothiophne (1) exhibited potent activity with IC$_{50}$ = 135 $\pm $ 0.51 $\mu $M, while its derivative 2,7-bis(butoxycarbonyl)-3,6-dichlorobenzo[1,2-$b$;6,5-$b$']dithiophene (2) exhibited promising inhibition with IC$_{50}$ = 263 $\pm $ 0.32 $\mu $M. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, compound 2 exhibited promising activity with IC$_{50}$ = 33 $\pm $ 0.42 $\mu $M, while compound 1 showed moderate inhibition in the urease …

Differential Pulse Voltammetric Determination Of Dopamine Using Pd Nanoparticles Deposited On (3-Aminopropyl)Triethoxysilane Functionalized Ceo$_{2}$ Nanoparticles, Muhammet Güler

Turkish Journal of Chemistry

In this study, a novel and effective electrochemical sensor for determination of dopamine (DA) was successfully developed by the modification of a glassy carbon electrode (GCE) using Pd nanoparticles deposited on (3-aminopropyl)triethoxysilane functionalized nanoceria (Pd@CeO$_{2}$-APTES) and nafion used as a protective membrane. The synthesized nanocomposites were evaluated using X-ray diffraction, high-resolution transmission electron microscopy, and Fourier transform infrared spectroscopy. Moreover, the electrochemical properties of the modified electrodes were investigated using cyclic voltammetry, electrochemical impedance voltammetry, and differential pulse voltammetry (DPV). The Nf/Pd@CeO$_{2}$-APTES/GCE showed a linear range of 2.5--149.5 $\mu $M for DA by DPV with a notable sensitivity of 3.89 …

Use Of Calcined Layered Double Hydroxide [Zn$_{2}$-Al-Co$_{3}$] For Removal Of Textile Dye Acid Green 1 From Wastewater: Kinetic, Equilibrium, Comparative, And Recycling Studies, El Hassane Mourid, Mohamed Lakraimi, Souad El Abridi, Lhaj Benaziz, El Hassan Elkhattabi, Moha Berraho

Turkish Journal of Chemistry

In the present study, calcined layered double hydroxides (CLDHs) were obtained by heating [Zn$_{2}$-Al-CO$_{3}$] at 500 $^{\circ}$C. The adsorption of the textile dye acid green 1 (AG1) by CLDH was carried out at different pH levels, adsorbent--adsorbate contact times, and AG1/CLDH mass ratios. Equilibrium at room temperature was reached after 24 h, which was confirmed by the kinetic modeling of the experimental data by the pseudo-second-order model. The adsorption is described by a Langmuir-type isotherm. The comparative study of adsorption isotherms in calcined and uncalcined phases reveals that the former could be a good candidate for trapping such pollutants. After …

Teaching Chemistry In A Spiral Progression Approach: Lessons From Science Teachers In The Philippines, Joymie R. Orbe, Allen A. Espinosa, Janir T. Datukan

Australian Journal of Teacher Education

As the Philippines moves towards implementing the K-12 curriculum, there has been a mismatch in teacher preparation in science. The present teacher education curriculum prepares science teachers to specialise in a specific field (e.g. integrated science, biology, chemistry, and physics). However, in the K-12 curriculum, they are required to teach all the sciences in a spiral progression approach. Hence, this study analysed the experiences of science teachers in teaching chemistry in the K-12 curriculum in order to identify their challenges and how they are overcoming them. Findings suggest that the teacher’s content, pedagogy, and assessment in chemistry are problematic; specifically, …

Poems Found Among The Resolution Scrapbooks: A Teacher Narrative Inquiry, Cynthia M. Morawski

Australian Journal of Teacher Education

Six pre-service teachers participated in a component of narrative inquiry that took place the week before their teacher education program began. The component offered the teachers a variety of multimodal activities, such as body biographies, teaching museums, and paper tearing representations, all making use of repurposed materials, to critically consider their recurring narratives in relation to their recurring pedagogical beliefs and practices. Handmade journals and resolution scrapbooks acted as places to reflect and record their responses (Author). For this paper, I turned to narrative inquiry supported by found poetry and focus on the part of the component that contains the …

‘Aboriginal Learning Style’ And Culturally Responsive Schooling: Entangled, Entangling, And The Possibilities Of Getting Disentangled, Greg Vass

Australian Journal of Teacher Education

Arising from the author’s experiences as a high school teacher, and now teacher educator and education researcher, this article is motivated by concerns to do with ‘good’ schooling practices in connection with Indigenous education in Australia. More specifically, the paper critically considers the enduring and worrying influences of ‘Aboriginal learning style theory’, alongside considering the possibilities of culturally responsive approaches. While interest in culturally responsive schooling is growing, the argument put forward here is that concomitant with these efforts, more attention needs to be invested into teasing out how and why this approach differs from learning styles in significant ways, …

Two-Area Load Frequency Control With Redox Ow Battery Using Intelligentalgorithms In A Restructured Scenario, Lakshmi Dhandapani, Fathima Peer, Ranganath Muthu

Turkish Journal of Electrical Engineering and Computer Sciences

Load frequency control (LFC) is an essential aspect of power system dynamics. This paper focuses on the optimization of LFC for a two-area deregulated power system under different scenarios. A recent nature-inspired ower pollination algorithm (FPA), based on the pollination process of plants, is used to tune the proportional integral (PI) controller parameters of LFC for the global minima solution. FPA is compared with a genetic algorithm, particle swarm optimization, and a conventional PI controller. During large load disturbance in the areas, controllers are incapable of reducing frequency deviations and tie-line power oscillations due to the slow response of the …

An Elitist Approach For Solving The Traveling Salesman Problem Using An Animalmigration Optimization Algorithm, Ezgi̇ Ülker

Turkish Journal of Electrical Engineering and Computer Sciences

This paper presents an improved version of the animal migration optimization (AMO) algorithm for solving the traveling salesman problem (TSP), which is classified as a combinatorial NP-hard problem. AMO is one of the recent metaheuristic algorithms inspired by the migration behavior of animals and has been efficiently applied to a variety of optimization problems. The algorithm is improved by reconstructing the neighborhood topology of each animal during the migration. This modified algorithm is called the elitist animal migration optimization (ELAMO) algorithm, since elitism is introduced as a way in which the positions of the leaders are considered for the neighborhood …

A Novel Solution In The Simultaneous Deep Optimization Of Rgb-D Camera Calibration Parameters Using Metaheuristic Algorithms, Amir Safaei, Saeid Fazli

Turkish Journal of Electrical Engineering and Computer Sciences

This article presents a novel method for estimating 19 parameters of RGB and depth camera calibration simultaneously. The proposed algorithm is based on applying metaheuristic methods for deep optimization and estimating all parameters of intrinsic, extrinsic, and lens distortions of cameras. This paper compares four metaheuristic algorithms, i.e. a genetic algorithm, particle swarm optimization, the colonial competitive algorithm, and the shuffled frog leaping algorithm, with a numerical algorithm called singular value decomposition. The proposed method does not need the initial estimation for optimization and it can avoid being trapped in local minima. By using nondirect estimation, we achieve middle computing …

Upper Envelope Detection Of Ecg Signals For Baseline Wander Correction: A Pilot Study, Mohammed Assam Ouali, Mouna Ghanai, Kheireddine Chafaa

Turkish Journal of Electrical Engineering and Computer Sciences

Baseline wander (BW) is a common low frequency artifact in electrocardiogram (ECG) signals. The prime cause from which BW arises is the patient's breathing and movement. To facilitate reliable visual interpretation of the ECG and to discern particular patterns in the ECG signal, BW needs to be removed. In this paper, a novel BW removal method is presented. The hypothesis is based on the observation that ECG signal variation covaries with its BW. As such, the P, Q, R, S, and T peaks will follow the baseline drift. On this basis, the following proposition is true: a reliable approximation of …

The Efficacy Of Commercial Tooth Storage Media For Maintaining The Viability Of Human Periodontal Ligament Fibroblasts, W. Lee, Sheila E. Stover, Morteza Rasoulianboroujeni, K. Sherman, Farahnaz Fahimipour, E. Dashtimoghadam, C. Zito, Hossein E. Jazayeri, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Aim

To evaluate Save‐A‐Tooth (SAT), EMT Toothsaver (EMT) and Hank's Balanced Salt Solution (HBSS) for their influence on the viability and proliferative capacity of human periodontal ligament fibroblasts (HPDLFs).

Methodology

Primary HPDLFs were seeded into 96‐well cell culture plates and exposed to SAT, EMT, HBSS and water (negative control) for 0.5, 1, 3, 6, 12 and 24 h at room temperature (22 °C). After each exposure time, cell viability was measured through quantifying adenosine triphosphate (ATP) using a luminescent dye. The proliferative capacity was also quantified using the PrestoBlue assay after 12 or 24 h storage in each medium. The …