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2018

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Immunogenicity And Protective Activity Of A Chimeric Protein Based On The Domain Iii Of The Tick-Borne Encephalitis Virus E Protein And The Ompf Porin Of Yersinia Pseudotuberculosis Incorporated Into The Ti-Complex, Nina M. Sanina, Natalia Chopenko, Andrey Mazeika, Ludmila Davydova, Galina Leonova, Anna Stenkova, Vladimir N. Uversky, Eduard Kostetsky Jan 2018

Immunogenicity And Protective Activity Of A Chimeric Protein Based On The Domain Iii Of The Tick-Borne Encephalitis Virus E Protein And The Ompf Porin Of Yersinia Pseudotuberculosis Incorporated Into The Ti-Complex, Nina M. Sanina, Natalia Chopenko, Andrey Mazeika, Ludmila Davydova, Galina Leonova, Anna Stenkova, Vladimir N. Uversky, Eduard Kostetsky

Molecular Medicine Faculty Publications

Tick-borne encephalitis (TBE) is a widespread, dangerous infection. Unfortunately, all attempts to create safe anti-TBE subunit vaccines are still unsuccessful due to their low immunogenicity. The goal of the present work was to investigate the immunogenicity of a recombinant chimeric protein created by the fusion of the EIII protein, comprising domain III and a stem region of the tick-borne encephalitis virus (TBEV) E protein, and the OmpF porin of Yersinia pseudotuberculosis (OmpF-EIII). Adjuvanted antigen delivery systems, the tubular immunostimulating complexes (TI-complexes) based on the monogalactosyldiacylglycerol from different marine macrophytes, were used to enhance the immunogenicity of OmpF-EIII. Also, the chimeric …

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Security, Law & Public Policy - Assessing The Efficacy Of A National Security Vs. Law Enforcement Model To Combat Terrorism, Marvin L. Astrada Jan 2018

Security, Law & Public Policy - Assessing The Efficacy Of A National Security Vs. Law Enforcement Model To Combat Terrorism, Marvin L. Astrada

St. Thomas Law Review

The relationship between security, law, and public policy, generally speaking, is one fraught with tension. This is the case, in part, because security has the potential for limitless application. During the campaign and since taking office, candidate (and later President) Trump clearly espoused an emphasis on security in order to "Make America Great Again." Securitization measures from a political, economic, sociocultural, and foreign policy perspective were key pillars of President Trump's campaign and have informed Executive policy-making since Trump assumed office. In the present highly contentious political environment, wherein the Executive has vigorously articulated and pursued an expansive sociopolitical and …

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Oxidative Stress Induces Club Cell Proliferation And Pulmonary Fibrosis In Atp8b1 Mutant Mice, Jutaro Fukumoto, Joseph Leung, Ruan Cox Jr, Alexander Czachor, Prasanna Tamarapu Parthasarathy, Venu Lagishetty, Maria Mandry, Nima Hosseinian, Priyanshi Patel, Brittany Perry, Mason T. Breitzig, Matthew Alleyn, Athena Failla, Young Cho, Andrew J. Cooke, Lakshmi Galam, Ramani Soundararajan, Nirmal Sharma, Richard F. Lockey, Narasaiah Kolliputi Jan 2018

Oxidative Stress Induces Club Cell Proliferation And Pulmonary Fibrosis In Atp8b1 Mutant Mice, Jutaro Fukumoto, Joseph Leung, Ruan Cox Jr, Alexander Czachor, Prasanna Tamarapu Parthasarathy, Venu Lagishetty, Maria Mandry, Nima Hosseinian, Priyanshi Patel, Brittany Perry, Mason T. Breitzig, Matthew Alleyn, Athena Failla, Young Cho, Andrew J. Cooke, Lakshmi Galam, Ramani Soundararajan, Nirmal Sharma, Richard F. Lockey, Narasaiah Kolliputi

Molecular Medicine Faculty Publications

Atp8b1 (ATPase, aminophospholipid transporter, class I, type 8B, member 1) is a cardiolipin transporter in the apical membrane of lung epithelial cells. While the role of Atp8b1 in pneumonia-induced acute lung injury (ALI) has been well studied, its potential role in oxidative stress-induced ALI is poorly understood. We herein show that Atp8b1G308V/G308V mice under hyperoxic conditions display exacerbated cell apoptosis at alveolar epithelium and aberrant proliferation of club cells at bronchiolar epithelium. This hyperoxia-induced ambivalent response in Atp8b1G308V/G308V lungs was followed by patchy distribution of non-uniform interstitial fibrosis at late recovery phase under normoxia. Since this club cell abnormality is …

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Deciphering The Dark Proteome Of Chikungunya Virus, Ankur Singh, Ankur Kumar, Rakhi Yadav, Vladimir N. Uversky, Rajanish Giri Jan 2018

Deciphering The Dark Proteome Of Chikungunya Virus, Ankur Singh, Ankur Kumar, Rakhi Yadav, Vladimir N. Uversky, Rajanish Giri

Molecular Medicine Faculty Publications

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. The outbreak of CHIKV infection has been seen in many tropical and subtropical regions of the biosphere. Current reports evidenced that after outbreaks in 2005–06, the fitness of this virus propagating in Aedes albopictus enhanced due to the epistatic mutational changes in its envelope protein. In our study, we evaluated the prevalence of intrinsically disordered proteins (IDPs) and IDP regions (IDPRs) in CHIKV proteome. IDPs/IDPRs are known as members of a ‘Dark Proteome’ that defined as a set of polypeptide segments or whole protein without unique three-dimensional structure within the cellular milieu but …

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Intrinsic Disorder And Posttranslational Modifications: The Darker Side Of The Biological Dark Matter, April L. Darling, Vladimir N. Uversky Jan 2018

Intrinsic Disorder And Posttranslational Modifications: The Darker Side Of The Biological Dark Matter, April L. Darling, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs) are functional proteins and domains that devoid stable secondary and/or tertiary structure. IDPs/IDPRs are abundantly present in various proteomes, where they are involved in regulation, signaling, and control, thereby serving as crucial regulators of various cellular processes. Various mechanisms are utilized to tightly regulate and modulate biological functions, structural properties, cellular levels, and localization of these important controllers. Among these regulatory mechanisms are precisely controlled degradation and different posttranslational modifications (PTMs). Many normal cellular processes are associated with the presence of the right amounts of precisely activated IDPs at right …

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Parenting Stress, Parenting, And Adolescent Externalizing Problems : Exploring The Associations Among Parents Of Adolescents, Kristina Kochanova Jan 2018

Parenting Stress, Parenting, And Adolescent Externalizing Problems : Exploring The Associations Among Parents Of Adolescents, Kristina Kochanova

Graduate Research Theses & Dissertations

There is growing evidence that parenting stress maintains a strong influence on child externalizing problems; however this link has not been widely studied with adolescent populations. Adolescence can be a period of transitions and is linked to rising levels of parenting stress and negative adolescent outcomes. Thus, it is important to explore the influence of parenting stress on adolescent externalizing problems with parents of adolescents to inform how to parent adolescents, reduce the risk of adolescent deviant behaviors, and promote a smoother transition into young adulthood. Previous evidence also suggests that parenting stress is linked to parenting behaviors, parenting behaviors …

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Effective Disorder Strength And Fractal Dimension Of Biologically Relevant Systems, Ethan Ross Avery Jan 2018

Effective Disorder Strength And Fractal Dimension Of Biologically Relevant Systems, Ethan Ross Avery

Electronic Theses and Dissertations Archive

In this thesis, therefore, in order to properly relate the competition between fractal dimension of a system to its optical scattering properties, and to find the fractal dimension for which maximum scattering occurs, we have performed a systematic characterization of the disorder properties of fractal biological samples with a wide range of fractal dimensions. As cells/tissues are dielectric media, we have indirectly characterize the effective disorder of the fractal media based on their eigenvalues/eigenfunction in a closed-boundary condition using optical waves. We observed a non-monotonous behavior due to the competition between decreases in fractality verses increasing scattering centers.

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Polypyrrole (Ppy) Coated Patterned Vertical Carbon Nanotube (Pvcnt) Dry Ecg Electrode Integrated With A Novel Wireless Resistive Analog Passive (Wrap) Ecg Sensor, Mohammad Jomah I. Abu Saude Jan 2018

Polypyrrole (Ppy) Coated Patterned Vertical Carbon Nanotube (Pvcnt) Dry Ecg Electrode Integrated With A Novel Wireless Resistive Analog Passive (Wrap) Ecg Sensor, Mohammad Jomah I. Abu Saude

Electronic Theses and Dissertations Archive

Biopotential signals such as electroencephalography (EEG), electrocardiography (ECG or EKG), electrooculogram (EOG), and electromyography (EMG) play vital roles in health and clinical diagnoses, monitoring, and therapy. In addition, these signals are required for many nonclinical applications such as Neurofeedback and Brain-Computer Interface (BCI). The quality of the measurement relies on the electrical and mechanical properties of the electrode. Conventional wet or gel impedimetric electrodes provide an excellent signal due to the conductive fluids or gel, which reduces the skin-contact impedance and maintains contact during movement. However, they operate for a short duration; the quality of the signal degrades due to …

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Reduction Of Oxidative Stress And Storage Lesions (Rcsl) In Red Blood Cells: Analysis Of Ascorbic Acid (Aa), N-Acetylcysteine Amide (Ad4), And Serotonin (5-Ht), Shanmuka Gadiraju Jan 2018

Reduction Of Oxidative Stress And Storage Lesions (Rcsl) In Red Blood Cells: Analysis Of Ascorbic Acid (Aa), N-Acetylcysteine Amide (Ad4), And Serotonin (5-Ht), Shanmuka Gadiraju

AUCTUS: The Journal of Undergraduate Research and Creative Scholarship

Oxidative stress is a common occurrence in red blood cell (RBC) storage in blood banks throughout the world. Typically RBC units stored under routine standard protocol (stored in SAGM-CPD additive solution) can only be kept up to forty-two days for transfusion usage before being discarded. I am studying the effects of Ascorbic Acid (AA), N-acetylcysteine amide (AD4), and Serotonin or 5-hydroxytryptamine (5- HT) as additives in blood bank storage to find out if these additives can reduce storageinduced oxidative stress on red blood cells (RBCs), as well as to understand how potential blood storage additives can affect the shelf life …

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The Cost Of The Government's Failure To Protect Children Witnessing Parental Arrest And Detainment, Tiffany Simmons, Bahiyyah Muhammad, Kasandra Dodd Jan 2018

The Cost Of The Government's Failure To Protect Children Witnessing Parental Arrest And Detainment, Tiffany Simmons, Bahiyyah Muhammad, Kasandra Dodd

American University Business Law Review

No abstract provided.

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Do Early Childhood Body Mass Index Trajectories Affect School Readiness, Socioemotional Development, Or Cognition? Findings From The Candle Study., Lauren Michelle Sims Taylor Jan 2018

Do Early Childhood Body Mass Index Trajectories Affect School Readiness, Socioemotional Development, Or Cognition? Findings From The Candle Study., Lauren Michelle Sims Taylor

Electronic Theses and Dissertations Archive

Sims Taylor, Lauren M., PhD. The University of Memphis. December 2018. Early childhood weight status and its effects on socioemotional development, school readiness, and cognition.Major Professor: Vikki Nolan, DSc, MPHChildhood obesity is associated with negative health and social outcomes in school-age children. These effects range from absenteeism and poor self-esteem to worse test scores, and fewer completed grades. Although previous studies have found these associations in school-age children and adolescents, less is known about this association in young children, who are just beginning school. Additionally, many studies of the outcomes of obesity are limited by cross-sectional study designs. These projects …

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An Analysis Of The Relationship Between Teachers Perceived Involvement In Secondary School Decision-Making And Concurrent Student Attendance Rate, Suspension Rate, Graduation Rate, And Dropout Rate, Kendra Ashford-Hightower Jan 2018

An Analysis Of The Relationship Between Teachers Perceived Involvement In Secondary School Decision-Making And Concurrent Student Attendance Rate, Suspension Rate, Graduation Rate, And Dropout Rate, Kendra Ashford-Hightower

Electronic Theses and Dissertations Archive

AbstractThe purpose of this study was to examine the relationships between secondary level teachers perceived involvement with respect to their making pedagogical and administrative decisions at their schools and four measures of school productivity. Grounded in archived accountability information stored on the Tennessee Department of Education website, these four productivity measures were the student attendance, graduation, suspension, and event dropout rates computed for 248 high schools for the 2012-2013 academic year. At these same 248 institutions, teachers perceived involvement was computed from responses to a section on teachers roles in decision making that appeared on the 2013 state-wide administration of …

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Automated Artifact Removal And Detection Of Mild Cognitive Impairment From Single Channel Electroencephalography Signals For Real-Time Implementations On Wearables, Saleha Khatun Jan 2018

Automated Artifact Removal And Detection Of Mild Cognitive Impairment From Single Channel Electroencephalography Signals For Real-Time Implementations On Wearables, Saleha Khatun

Electronic Theses and Dissertations Archive

Electroencephalogram (EEG) is a technique for recording asynchronous activation of neuronal firing inside the brain with non-invasive scalp electrodes. EEG signal is well studied to evaluate the cognitive state, detect brain diseases such as epilepsy, dementia, coma, autism spectral disorder (ASD), etc. In this dissertation, the EEG signal is studied for the early detection of the Mild Cognitive Impairment (MCI). MCI is the preliminary stage of Dementia that may ultimately lead to Alzheimers disease (AD) in the elderly people. Our goal is to develop a minimalistic MCI detection system that could be integrated to the wearable sensors. This contribution has …

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Nanotechnology-Based Cancer Phototherapy And Circulating Tumor Cell Analysis, Ryan Timothy O'Connor Jan 2018

Nanotechnology-Based Cancer Phototherapy And Circulating Tumor Cell Analysis, Ryan Timothy O'Connor

Electronic Theses and Dissertations Archive

Gold and hybrid gold nanotechnology are uniquely poised to improve the fields of cancer diagnosis and therapy. Modifying gold nanoparticles with biological proteins has been widely used for decades, however, the common carbodiimide technique requires steps that reduce sensitivity and effectiveness in some spectroscopic techniques. We have developed an antibody conjugation protocol which conducts linking first, and then covalently adheres the antibody-linker complex to the nanoparticle surface. The linking polymer N-hydroxysuccinimide-polyethylene glycol-thiol (NHS-PEG-SH) was incubated with a protein overnight and purified by centrifuge filtration before modifying the surface of gold nanoparticles by slow mixing. The method was transferred to antibody …

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The Effects Of Diet And Food Deprivation On The Sexual And Exploratory Behaviors Of Meadow Voles, Microtus Pennsylvanicus, Lyndsey Marie Pierson Jan 2018

The Effects Of Diet And Food Deprivation On The Sexual And Exploratory Behaviors Of Meadow Voles, Microtus Pennsylvanicus, Lyndsey Marie Pierson

Electronic Theses and Dissertations Archive

The meadow vole (Microtus pennsylvanicus) is a small herbivorous rodent inhabiting grassy fields throughout the Northern United States and Canada. Meadow voles are promiscuous, with males and females taking multiple mates during a single breeding season. Female meadow voles are territorial while males occupy large home ranges that encompass the territories of multiple females. My research focused on how changes in diet or food availability influenced the sexual and exploratory behaviors of meadow voles. In Chapters 1 and 2, I assessed the influence of phytoestrogens on the sexual behavior of meadow voles. Phytoestrogens are nonsteroidal compounds produced by plants that …

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Application Of Computational Methods To Prioritize Experiments Focused On Biomolecular Drug Targets, Babatunde Adebiyi Raji Jan 2018

Application Of Computational Methods To Prioritize Experiments Focused On Biomolecular Drug Targets, Babatunde Adebiyi Raji

Electronic Theses and Dissertations Archive

SK1 is an intracellular enzyme whose lipid kinase activity regulates the levels of bioactive lipids that are involved in normal homeostasis and disease. SK1 activity is implicated in various diseases including cancer, and inhibition of SK1 activity is a potential treatment for its implicated pathogenesis. However, without a high-throughput SK1 activity assay, screening and identification of SK1 inhibitors is a rigorous process that requires significant time and resources to yield potent lead compounds. In order to develop a high-throughput SK1 assay method, an optically active non-lipid SK1 substrate was designed for the purpose of monitoring activity in real-time. Evaluation of …

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The Transgenerational Effect Of Maternal Grandmothers Body Mass Index And Socioeconomic Status On Offspring Birth Weight: The Mediation Effect Of Maternal Birth Weight, Early Adulthood Bmi, And Dna Methylation, Yan Shen Jan 2018

The Transgenerational Effect Of Maternal Grandmothers Body Mass Index And Socioeconomic Status On Offspring Birth Weight: The Mediation Effect Of Maternal Birth Weight, Early Adulthood Bmi, And Dna Methylation, Yan Shen

Electronic Theses and Dissertations Archive

Prior research demonstrated intergenerational effects of maternal risk factors on offspring birth weight. However, only a limited number of studies investigated whether grand-maternal risk factors, i.e. body mass index (BMI) and socioeconomic status (SES), affected grandchilds birth weight (GBW). Besides, it is unknown whether such associations are direct or mediated by maternal risk factors. Grand-maternal smoking during pregnancy was additionally included due to many studies addressing the adverse effect of maternal smoking on birth weight. I used three-generation data from Isle of Wight birth cohort in UK and performed structural equation models (SEM) to assess the associations between grand-maternal risk …

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Attaining Scientific Literacy Through A Rhetoric Of Science Composition Pedagogy, Stephen C. Smith Jan 2018

Attaining Scientific Literacy Through A Rhetoric Of Science Composition Pedagogy, Stephen C. Smith

Electronic Theses and Dissertations Archive

For the past sixty years, acquiring scientific literacy has proven to be a daunting task in education, especially for undergraduate nonscience majors. Although some education scholars have recognized the importance and use of arguments to teach science, these pedagogical practices often are aimed at primary school children rather than college students or involve reporting science experiments rather than actually studying or constructing arguments about issues related to science.However, in this dissertation, I contend that educators often neglect a more available tool that not only examines arguments concerning scientific issues but also demonstrates the very heart of scientific literacy: critical thinking. …

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Framing The Global Pact For The Environment: Why It's Needed, What It Does, And How It Does It, Teresa Parejo Navajas, Nathan Lobel Jan 2018

Framing The Global Pact For The Environment: Why It's Needed, What It Does, And How It Does It, Teresa Parejo Navajas, Nathan Lobel

Fordham Environmental Law Review

No abstract provided.

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Mesoscopic Light Scattering Approach For Structural Disorder Analysis Of Biological Cells: Application In Cancer Diagnostics, Huda Almabadi Jan 2018

Mesoscopic Light Scattering Approach For Structural Disorder Analysis Of Biological Cells: Application In Cancer Diagnostics, Huda Almabadi

Electronic Theses and Dissertations Archive

Optical techniques are often used to study of biological cells and tissues to gain valuable information about them. Recently, the mesoscopic physics based light scattering techniques have provided unprecedented insight into the physical properties of biological systems. In particular, the mesoscopic light transport and light localization approaches allow to measure and quantify nano to micron scale structural alterations in the biological system. The applications of these techniques have been foreseen in efficient diseases diagnostics and therapeutic studies. Genesis and progression of diseases such as cancer is known to accompany with structural alterations in the building blocks of cells, such as …

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Examining Cerebellar Modulation Of Mesolimbic Dopamine Transmission Using Fixed Potential Amperometry, Zade Ramses Holloway Jan 2018

Examining Cerebellar Modulation Of Mesolimbic Dopamine Transmission Using Fixed Potential Amperometry, Zade Ramses Holloway

Electronic Theses and Dissertations Archive

Elucidating how dopamine neurons operate regularly in aspects of neurochemical release and in pathological systems is essential for understanding their role in behavior, drug treatment, and disease. Fixed-potential amperometry (FPA) combined with carbon fiber microelectrodes has proven to be effective at probing these dynamic microsystems and precisely describing the regulatory mechanisms that govern dopamine neurotransmission. To date, we have utilized FPA to: a) observe and quantify differences in the neurochemical profile of phasic dopamine release in major dopaminergic afferents including the striatum, nucleus accumbens (NAc), amygdala, and prefrontal cortex through stimulation of the medial forebrain bundle (MFB), b) provide evidence …

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Parental Ptsd, Emotion Regulation, And Behavior Problems In Toddlerhood: Unique Associations Among Families In Urban Poverty, Hasti Ashtiani Raveau Jan 2018

Parental Ptsd, Emotion Regulation, And Behavior Problems In Toddlerhood: Unique Associations Among Families In Urban Poverty, Hasti Ashtiani Raveau

Wayne State University Dissertations

Parental posttraumatic stress disorder (PTSD) has been shown to negatively impact children’s socioemotional development (Schwerdtfeger et al., 2014) and increase children’s risk for later psychopathology (Scheeringa & Zeanah, 2008; Yehuda, Halligan, & Bierer, 2001). Less is known about this topic among minority and poor mothers and fathers of toddlers, and the critical role parents’ emotion regulation may play in mediating the associations between PTSD and toddlers’ socioemotional problems (Beck et al., 2009). Parental emotion dysregulation has been linked with children’s socioemotional problems (Coyne & Thompson, 2011), especially during toddlerhood when children are beginning to learn how to regulate their own …

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Exploring The Short-Term Effects Of Probiotic And Prebiotic Supplementation On The Microbiota And Physiology Of Male C57bl/6 Mice, Miguel Angel Rivas Jan 2018

Exploring The Short-Term Effects Of Probiotic And Prebiotic Supplementation On The Microbiota And Physiology Of Male C57bl/6 Mice, Miguel Angel Rivas

Wayne State University Theses

The gut microbiome may play a role in the development of chronic diseases like obesity, diabetes, and heart disease. Diets including prebiotics or probiotics can alter the abundance of gut bacterial groups and have subsequent health effects. In this study we wanted to establish a method for comparing the benefits of commercial supplements that alter the microbiota by monitoring fecal microbial profiles in male C57BL/6 mice (n = 24) exposed to 15 days of dietary supplementation. A probiotic diet (VSL#3) and a prebiotic diet (potato starch) were compared to a standard diet (n = 8 for each group). Microbial profiles …

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The Frontal Assessment Battery: Relationship With Functional Status Indicators And Caregiver Burden In Veterans, Whitney Stubbs Jan 2018

The Frontal Assessment Battery: Relationship With Functional Status Indicators And Caregiver Burden In Veterans, Whitney Stubbs

Electronic Theses and Dissertations Archive

Objective: Neurocognitive screening measures reflective of functional status are needed for detection of executive dysfunction. The Frontal Assessment Battery (FAB), a measure designed to assess executive functioning at bedside, lacks sufficient research establishing its ecological validity. The purpose of the study was to evaluate the ecological validity of the FAB by examining its relationship with the Functional Status Interview (FSI), a measure of basic activities (ADL) and instrumental activities (IADL), and a measure of caregiver burden (ZBI-R). Method: Participants in the primary sample were 168 veterans with a mean age of 81.3 years (SD = 7.6). Prior to main analyses, …

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Chinese Middle And High School Students' Emotion Regulation: Intrapersonal And Interpersonal Approaches, Hui Zhang Jan 2018

Chinese Middle And High School Students' Emotion Regulation: Intrapersonal And Interpersonal Approaches, Hui Zhang

Electronic Theses and Dissertations Archive

The overall goal of this dissertation was to examine the adaptivenss of eight emotion regulation strategies for Chinese middle and high school students. The adaptiveness was evaluated by using an intrapersonal approach that focused on individual students in Study 1 and by using an interpersonal approach that focused on same-sex best friend dyads in Study 2. By using an intrapersonal approach, Study 1 found that students chose to use developing competencies, redirecting attention, expressive suppression, and seeking social support more often than the other four strategies. Among the eight emotion regulation strategies, developing competencies was the most adaptive and venting …

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Yoga Instructor Belief Scale: Instrument Development And Validation, Tegan Jemma Reeves Jan 2018

Yoga Instructor Belief Scale: Instrument Development And Validation, Tegan Jemma Reeves

Electronic Theses and Dissertations Archive

In response to the growing interest in mind-body practices as preventative, therapeutic and educational interventions, the current work describes the instrument development and validation process to address a gap in yoga research. Yoga is a mind-body practice used in clinical and school settings that uses an integrative curriculum which simultaneously targets skill development/maintenance in physical, cognitive and emotional realms. Yoga is heterogeneous, as there is variability across styles and interventions. Yoga is also educational, as there are integrative skills being learned. The heterogeneous and educational nature of yoga necessitates reporting that accounts for variability in the instruction across instructors of …

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Place, Identity, And Language Learning: The Transformative Role Of Place-Based English Language Instruction, Daniel Scott Harper Jan 2018

Place, Identity, And Language Learning: The Transformative Role Of Place-Based English Language Instruction, Daniel Scott Harper

Electronic Theses and Dissertations Archive

This study examines the intersections of place and second language learning. Learner identity has been found to be an important construct in second language learning. In recent years, place and space have become central topics in the study of sociolinguistics and identity. One area of place and language that has not been studied in depth, however, is whether place plays a role in second language learning. This study begins to fill this gap by examining the second language learning experiences of thirteen Japanese study abroad students who were enrolled in an eight-week, content-based language course. The content of the course …

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Considering Microbial Pesticides As A Disease Mitigation Strategy For The Amphibian Fungal Disease, Chytridiomycosis, Denita Mychele Weeks Jan 2018

Considering Microbial Pesticides As A Disease Mitigation Strategy For The Amphibian Fungal Disease, Chytridiomycosis, Denita Mychele Weeks

Electronic Theses and Dissertations Archive

Chytridiomycosis is an infectious amphibian disease caused by the pathogenic fungus Batrachochytrium dendrobatidis (Bd). Bd attaches to keratin on the epidermis of amphibians, invades skin cells, and may lead to pathogenesis in susceptible individuals. However, susceptibility varies within and among species. While this is due to many factors, the skin microbial community is a significant contributor to disease resistance. Amphibians form symbiotic relationships with environmental microbes on the skin surface, some of which produce antifungal agents that inhibit Bd. Interestingly, many agricultural biopesticides utilize the common soil-dwelling bacteria, Bacillus thuringiensis. Through agricultural use, these bacteria likely increase in environmental abundance …

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Efficient Solution Of Minimum Cost Flow Problems For Large-Scale Transportation Networks, Yuan Zhou Jan 2018

Efficient Solution Of Minimum Cost Flow Problems For Large-Scale Transportation Networks, Yuan Zhou

Electronic Theses and Dissertations Archive

With the rapid advance of information technology in the transportation industry, of which intermodal transportation is one of the most important subfields, the scale and dimension of problem sizes and datasets is rising significantly. This trend raises the need for study on improving the efficiency, profitability and level of competitiveness of intermodal transportation networks while exploiting the rich information of big data related to these networks. Therefore, this dissertation aims to investigate intermodal transportation network design problems, especially practical optimization problems, and to develop more realistic and effective models and solution approaches that will assist network operators and/or decision makers …

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Map3k4 Controls The Chromatin Modifier Hdac6 During Trophoblast Stem Cell Epithelial To Mesenchymal Transition, Robert Jackson Mobley Jan 2018

Map3k4 Controls The Chromatin Modifier Hdac6 During Trophoblast Stem Cell Epithelial To Mesenchymal Transition, Robert Jackson Mobley

Electronic Theses and Dissertations Archive

The first epithelial to mesenchymal transition (EMT) occurs in trophoblast stem (TS) cells during implantation. Inactivation of the serine/threonine kinase MAP3K4 in TS cells (TSKI4 cells) induces an intermediate state of EMT, where cells retain stemness, lose epithelial markers, and gain mesenchymal characteristics. Investigation of relationships among MAP3K4 activity, stemness, and EMT in TS cells may reveal key regulators of EMT. Here, we show that MAP3K4 activity controls EMT through the ubiquitination and degradation of HDAC6. Loss of MAP3K4 activity in TSKI4 cells results in elevated HDAC6 expression and the deacetylation of cytoplasmic and nuclear targets. In the nucleus, HDAC6 …

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