Digital Commons Network^™

The Role Of Arginyltransferase Ate1 In Prostate Cancer Progression, Michael D. Birnbaum

Open Access Dissertations

Prostate cancer is a major disease affecting millions of men every year, with hundreds of thousands of new diagnoses and tens of thousands of deaths per year. Most deaths from prostate cancer result from metastasis of the disease. However, the causes for metastasis of prostate cancer (PC) remain poorly understood, making its prediction and treatment a major challenge. Recently, a significant reduction of Arginyltranferase1 (Ate1) was observed in prostate cancer remote metastatic sites, suggesting Ate1 may be involved in the progression of PC. However, the exact role of Ate1 in PC remains unknown. Ate1 is the enzyme that mediates arginylation, …

Advances In Automotive Conversion Coatings During Pretreatment Of The Body Structure: A Review, Mark Doerre, Larry Hibbitts, Gabriela Patrick, Nelson K. Akafuah

Institute of Research for Technology Development Faculty Publications

Automotive conversion coatings consist of layers of materials that are chemically applied to the body structures of vehicles before painting to improve corrosion protection and paint adhesion. These coatings are a consequence of surface-based chemical reactions and are sandwiched between paint layers and the base metal; the chemical reactions involved distinctly classify conversion coatings from other coating technologies. Although the tri-cationic conversion coating bath chemistry that was developed around the end of the 20th century remains persistent, environmental, health, and cost issues favor a new generation of greener methods and materials such as zirconium. Environmental forces driving lightweight material selection …

Communicating Science Through Data Visualization Bio 230g, Michael Cerbo

Library Impact Statements

No abstract provided.

Spartan Daily, November 15, 2018, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2018

Volume 151, Issue 37

First Complete Genome Sequence Of A Genotype A2, Subgroup 4 Small Ruminant Lentivirus, Aspen M. Workman, Michael L. Clawson, Michael P. Heaton, Aaron M. Dickey

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Genetic variation in the ovine TMEM154 gene associates with susceptibility to small ruminant lentivirus (SRLV) infection. We report here the first complete genome sequence for a genotype A2, subgroup 4 SRLV isolated from a Hampshire ewe with two copies of a TMEM154 frameshift mutation predicted to abolish protein function.

The Setonian, November 15, 2018, Seton Hall University

2018

No abstract provided.

College Senate Minutes November 15, 2018, Bronx Community College Senate

BCC Governance Archives

Minutes for the meeting of the College Senate on November 15, 2018.

Prospectus, November 15. 2018, Parkland College, Ayla Mcdonald, Ashley House, Paul Benson, Savannah Weishaar, Emma Fleming, Morgan Parrish

Prospectus 2018

From Isolation to Academia: The educational journey of a home-schooled student; Humans of Parkland (Joseph Omo-Osagie); Stay Tuned for Radio Dramas on WPCD; Fight Hunber and Feed Hope; Peer Tutors' new CRLA Certification; Humane Society: Bios of 5 Pets up for Adoption; Letters to the editor;

Students Use Fruit Flies To Study Molecular Basis Of Alzheimer's Disease, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

A Human-Environment Systems Approach To Outdoor Recreation, Human Biological Stress, And Landscape Aesthetics, Ellie Opdahl, Kathryn Demps, Julie Heath

MILES Data Sets

Outdoor recreation, as the intersection between physical exercise and nature, provides a multitude of psychological and physiological benefits to human well-being. Though many studies have reported qualitative stress reduction from outdoor recreation, few have focused on quantitative measurements of stress across recreational activity types, intrapersonal differences, and environmental variables. To determine whether outdoor recreation affects physiology, we collected 190 paired salivary cortisol and testosterone samples and 157 surveys from 88 hikers, 81 mountain bikers, and 44 off-highway vehicle (OHV) motorists. After recreation, cortisol concentrations were significantly reduced in hikers and OHV motorists, but cortisol and testosterone concentrations increased in mountain …

Chemistry Doctoral Student Synthesizes Peptide To Understand Alzheimer's Progression, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Htc Neuroscience Student Studies Underlying Pathology Of Rare Brain Condition, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Autophagy And Aging: Maintaining The Proteome Through Exercise And Caloric Restriction, Kurt A. Escobar, Nathan H. Cole, Christine M. Mermier, Trisha A. Vandusseldrop

Faculty Articles

Accumulation of dysfunctional and damaged cellular proteins and organelles occursduring aging, resulting in a disruption of cellular homeostasis and progressive degen-eration and increases the risk of cell death. Moderating the accrual of these defunctcomponents is likely a key in the promotion of longevity. While exercise is knownto promote healthy aging and mitigate age‐related pathologies, the molecular under-pinnings of this phenomenon remain largely unclear. However, recent evidencessuggest that exercise modulates the proteome. Similarly, caloric restriction (CR), aknown promoter of lifespan, is understood to augment intracellular protein quality.Autophagy is an evolutionary conserved recycling pathway responsible for thedegradation, then turnover of cellular proteins …

Curricular Report No. 2018-19-3 From The Graduate Council To The Faculty Senate, University Of Rhode Island Faculty Senate

Faculty Senate Bills

No abstract provided.

2018-November-15-New Employees, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Neonatal Vitamin A Injection Promotes Cattle Muscle Growth And Increases Oxidative Muscle Fibers, Bo Wang, Wei Nie, Xing Fu, Jeanene M. De Avila, Yannan Ma, Mei Jun Zhu, Martin Maquivar, Steven M. Parish, Jan R. Busboom, Mark L. Nelson, Min Du

Faculty Publications

© 2018 The Author(s). Background: Vitamin A and its metabolite, retinoic acid (RA), are important regulators of cell differentiation and organ morphogenesis. Its impact on beef cattle muscle growth remains undefined. Method: Angus steer calves were administrated with 0 (control) or 150,000IU vitamin A (retinyl palmitate in glycerol, i.m.) per calf at birth and 1 month of age. At 2 months of age, a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells. The resulting steers were harvested at 14months of age. Results: Vitamin A administration …

Gardner-Webb Students Join Alpha Chi Honor Society, Office Of University Communications

Gardner-Webb NewsCenter Archive

Gardner-Webb University inducted 37 members into Alpha Chi, a national collegiate honor society, in a ceremony held Nov. 11 in Blanton Auditorium in Hamrick Hall. Dr. Pam Dennis, dean of Dover Memorial Library, was inducted as an honorary member. When recognizing Dennis, Dr. June Hobbs, Alpha Chi sponsor, noted her commitment to students.

Recovery Of Phosphate And Dissolved Organic Matter From Aqueous Solution Using A Novel Cao-Mgo Hybrid Carbon Composite And Its Feasibility In Phosphorus Recycling, Ronghua Li, Jim J. Wang, Zengqiang Zhang, Mukesh Kumar Awasthi, Dan Du, Pengfei Dang, Qian Huang, Yichen Zhang, Lu Wang

Faculty Publications

Metal oxide-Carbon composites have been developed tailoring towards specific functionalities for removing pollutants from contaminated environmental systems. In this study, we synthesized a novel CaO-MgO hybrid carbon composite for removal of phosphate and humate by co-pyrolysis of dolomite and sawdust at various temperatures. Increasing of pyrolysis temperature to 900 °C generated a composite rich in carbon, CaO and MgO particles. Phosphate and humate can be removed efficiently by the synthesized composite with the initial solution in the range of pH 3.0–11.0. The phosphate adsorption was best fitted by pseudo-second-order kinetic model, while the humate adsorption followed the pseudo-second-order and the …

State V. Cheng Yang Clerk's Record V. 2 Dckt. 46828

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Proteolysis Of Methylated Sox2 Protein Is Regulated By L3mbtl3 And Crl4Dcaf5 Ubiquitin Ligase, Chunxiao Zhang, Feng Leng, Lovely Saxena, Nam Hoang, Jiekai Yu, Salvador Alejo, Logan Lee, Dandan Qi, Fei Lu, Hong Sun, Hui Zhang

Chemistry and Biochemistry Faculty Research

SOX2 is a dose-dependent master stem cell protein that controls the self-renewal and pluripotency or multipotency of embryonic stem (ES) cells and many adult stem cells. We have previously found that SOX2 protein is monomethylated at lysine residues 42 and 117 by SET7 methyltransferase to promote SOX2 proteolysis, whereas LSD1 and PHF20L1 act on both methylated Lys-42 and Lys-117 to prevent SOX2 proteolysis. However, the mechanism by which the methylated SOX2 protein is degraded remains unclear. Here, we report that L3MBTL3, a protein with the malignant-brain-tumor (MBT) methylation–binding domain, is required for SOX2 proteolysis. Our studies showed that L3MBTL3 preferentially …

Hawks' Herald -- Nov. 15, 2018, Roger Williams University

Hawk's Herald

No abstract provided.

Andrews Hosts Scifest And Image & Influence, Hannah Gallant

Andrews Agenda: Campus News

No abstract provided.

Distinct Migratory Properties Of M1, M2, And Resident Macrophages Are Regulated By ΑDΒ2And ΑMΒ2Integrin-Mediated Adhesion, Kui Cui, Christopher L. Ardell, Nataly P. Podolnikova, Valentin P. Yakubenko

ETSU Faculty Works

Chronic inflammation is essential mechanism during the development of cardiovascular and metabolic diseases. The outcome of diseases depends on the balance between the migration/accumulation of pro-inflammatory (M1) and anti-inflammatory (M2) macrophages in damaged tissue. The mechanism of macrophage migration and subsequent accumulation is still not fully understood. Currently, the amoeboid adhesion-independent motility is considered essential for leukocyte migration in the three-dimensional environment. We challenge this hypothesis by studying the contribution of leukocyte adhesive receptors, integrins αMβ2, and αDβ2, to three-dimensional migration of M1-polarized, M2-polarized, and resident macrophages. Both integrins have a moderate expression on M2 macrophages, while αDβ2 is upregulated …

Development Of Copper-Catalyzed Suzuki-Miyaura Coupling Using Alkylboron Reagents And Nickel-Catalyzed Alkene Dicarbofunctionalization Reactions, Prakash Basnet

Chemistry and Chemical Biology ETDs

This thesis is divided into two parts. The first part deals with the development of copper-catalyzed Suzuki-Miyaura coupling of alkylboron reagents for the first time. In the second part, we will discuss the development of novel nickel-catalyzed alkene dicarbofunctionalization reactions.

Part I. Cross-coupling reactions are versatile tools to form new carbon-carbon bonds and are widely used in the synthesis of various drug molecules, natural products and materials. However, these reactions are typically catalyzed by palladium, an expensive and rare metal which makes the reaction unsustainable in long-terms. Additionally, palladium-catalyzed cross-coupling reactions with alkylorganometallic reagents suffer from side reactions due to …

November 15, 2018, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

Multi-Resolution Analysis Of Large Molecular Structures And Interactions, Kasra Manavi

Computer Science ETDs

Simulation of large molecular structures and their interactions has become a major component of modern biomolecular research. Methods to simulate these type of molecules span a wide array of resolutions, from all atom molecular dynamics to model interaction energetics to systems of linear equations to evaluate population kinetics. In recent years, there has been an acceleration of molecular structural information production, primarily from x-ray crystallography and electron microscopy. This data has provided modelers the ability to produce better representations of these molecular structures. The purpose of this research is to take advantage of this information to develop multi-resolution models for …

Scalable, Biofunctional, Ultra-Stable Nano- Bio- Composite Materials Containing Living Cells, Patrick E. Johnson, C. Jeffrey Brinker, Graham Timmins, Jacob Agola, Jason Harper

Nanoscience and Microsystems ETDs

Three-dimensional encapsulation of cells within nanostructured silica gels or matrices enables applications as diverse as biosensors, microbial fuel cells, artificial organs, and vaccines. It also allows study of individual cell behaviors. Recent progress has improved the performance and flexibility of cellular encapsulation, yet there remains a need for robust scalable processes for large format production of cell-encapsulating materials. Here, we detail two novel techniques, that enable the large-scale production of functional Nano-Bio-Composites (NBCs) containing living cells within ordered 3-D lipid/silica nanostructures: 1) thick-casting and 2) spray drying. Furthermore, we detail a third technique for material scaling in which aqueous, silicate-based …

The George-Anne, Georgia Southern University

The George-Anne

• MCCURDY’S PAST ALLEGATIONS OF RACIAL HARASSMENT
• Campus Life
• Opinions
• News
• Puzzles
• Features
• Sports

Macrocheles Species (Acari: Macrochelidae) Associated With Human Corpses In Europe, Naila A. Che Kamaruzaman, Peter Mašán, Yelitza Velásquez, Alejandro González‑Medina, Anders Lindström, Henk R. Braig, M. Alejandra Perotti

Harold W. Manter Laboratory of Parasitology: Library Materials

The biology of macrochelid mites might offer new venues for the interpretation of the environmental conditions surrounding human death and decomposition. Three human corpses, one from Sweden and two from Spain, have been analysed for the occurrence of Macrochelidae species. Macrocheles muscaedomesticae (Scopoli) females were associated with a corpse that was found in a popular beach area of southeast Spain. Their arrival coincides with the occurrence of one of their major carrier species, the filth fly Fannia scalaris, the activity of which peaks during mid-summer. Macrocheles glaber (Müller) specimens were collected from a corpse in a shallow grave in …

Waardenburg Syndrome And Left Persistent Superior Vena Cava, Driss Raissi, Alexander Christie, Kimberly Applegate

Radiology Faculty Publications

Waardenburg syndrome (WS) is a rare genetic disorder secondary to neural crest cell developmental abnormalities. It is predominantly described as an auditory-pigmentary syndrome with diverse patient presentation, typically involving congenital sensorineural hearing loss and pigmentation abnormalities of the skin, hair, and iris. Other developmental abnormalities that may be associated with this syndrome are Hirschsprung's disease and a myriad of cardiovascular congenital defects. We present a case of a young girl with WS who found to have a persistent left superior vena cava (PLSVC) draining into the coronary sinus. The prevalence of PLSVC is increased in patients with chromosomal and genetic …