Digital Commons Network^™

The Cognitive And Functional Impact Of Open Heart Surgery: A Pilot Study Including Three Common Procedures (Coronary Artery Bypass Graft, Heart Valve Replacement, And Left Ventricular Assist Device), Robert Fix

Theses and Dissertations

This study investigated the impact of open heart surgery (Coronary Artery Bypass Graft, Heart Valve Replacement, or Left Ventricular Assist Device placement) on cognition, functional performance, and mood in the three months following surgery. The Montreal Cognitive Assessment (MoCA), Kettle Test (KT), Physical Self Maintenance Scale (PSMS), and Hospital Anxiety and Depression Scale (HD) measured global cognition, functional cognition, functional performance, and mood states, respectively.

Thirteen male participants (ages 38 – 75) completed assessments at four time points -- when they were scheduled for surgery, within one week prior to surgery, before hospital discharge after surgery, and three months after …

Mechanisms Regulating Axon Initial Segment Stability, Savannah D. Benusa

Theses and Dissertations

Axon initial segment (AIS) disruption has been described in a number of pathological environments where neuroinflammation is a contributing factor; however, whether this disruption is reversible in unknown. To address the principle of AIS structural recovery, we employed an acute neuroinflammatory model. Acute neuroinflammation induced disruption of AIS structural and functional domains and, importantly, upon resolution of neuroinflammatory conditions, was reversed.

Consistent with other studies, we observed a close interaction of microglia with AISs, and utilized this acute neuroinflammatory model to investigate the relationship between reactive microglia and AIS integrity. Gene expression analysis of microglial transcription profiles identified reactive oxygen …

Evolving Reproductive Isolation In The Parasitic Wasp Genus Cotesia, Justin P. Bredlau

Theses and Dissertations

Parasitic wasps are highly diverse and play a major role in suppression of herbivorous pest populations, but relatively little is known of the mechanisms driving their diversity. Molecular studies indicate that cryptic species complexes resulting from adaptations to specific hosts or host-foodplants may be common. The gregarious endoparasitoid, Cotesia congregata (Braconidae), is a model system for understanding parasitic wasp biology. It is reported to attack at least 15 species of sphingid caterpillars, most of which are plant family specialists. Molecular studies have demonstrated genetic differentiation of two host-foodplant complex sources originating from Manduca sexta on tobacco (MsT) and Ceratomia catalpae …

Synthesis And Analysis Of Gold Nanoclusters, Patrick Woodworth

Theses and Dissertations

Gold Nanoclusters are of particular interest due to their many possible applications across a wide range of scientific fields. More specifically, nano-sized gold particles have potential to be used in drug delivery systems, cancer therapy and catalysis. This dissertation focuses on improving our understanding of ligated gold nanoclusters by examining the role of a variety of phosphine based ligands, novel methods to produce monodisperse solutions, and investigating the kinetics of water soluble ligated gold nanoclusters.

The addition of ligands to solutions of Au have shown to produce small (< 20 Au atoms) clusters. All nanocluster solutions were prepared in a similar manner. Typically, a gold salt, either Chloro(triphenylphosphine) gold(I) (Au(PPh₃)Cl), or Potassium gold (III) chloride (KAuCl₄), were …

Using A Custom Landscape Classification To Understand The Factors Driving Site Occupancy By A Rapidly Declining Migratory Songbird, Elizabeth K. Schold

Theses and Dissertations

Land cover classifications are useful in a broad range of ecological applications, yet publicly available classifications are not always useful for the needs of specific projects. Custom classifications are always a possibility, however, they can be financially or computationally out of reach for many researchers. Here we present a custom 1m resolution land cover classification created using freely available imagery and a random forest classification approach. This classification detected shrub cover more accurately and at a finer resolution than previous classifications. With the creation of this map, we were then able to examine landscape factors influencing occupancy dynamics of the …

Assessment Of A Predicted Diguanylate Cyclase In Treponema Denticola, Dhara T. Patel

Theses and Dissertations

Periodontal disease is a progressive inflammatory condition that is characterized by the reabsorption of alveolar bone, the destruction of connective tissue, and edentulism. It is caused by a dysbiosis in the oral microbiome as a result of a shift from a Gram-positive aerobic bacterial population, to one that becomes more Gram-negative and anaerobic. Treponema denticola is thought to drive this diseased state based on its role as a keystone periopathogen. A major component of T.denticola’s invasiveness is its motility, which allows the spirochete to penetrate and disseminate through tissues. This motility, which has been seen to be crucial to …

Zebrafish Model Of Mll-Rearranged Acute Myeloid Leukemia, Alex J. Belt

Theses and Dissertations

Acute myeloid leukemia (AML) is the second most common type of leukemia and accounts for 80% of adult acute leukemia cases and is characterized by the accumulation of poorly or undifferentiated myeloid blast cells. Standard treatment includes chemotherapy, which if unsuccessful, is followed by more rigorous chemotherapy as well as stem cell transplantation. Considering most patients are over the age of 45, these more rigorous therapies are not always possible, and as such, new therapies must be developed. Furthermore, AML patients harboring a chromosomal rearrangement involving Multiple Lineage Leukemia (MLL) that results in the expression of an MLL fusion protein …

Understanding The Role Of Sport For Development In Addressing Health Disparities In Low-Ses Communities, Tiesha R. Martin

Theses and Dissertations

The purpose of this study was to understand the role of Sport for Development (SFD) in addressing health disparities in low-SES communities. This was done using a multiple case study design, in which administrators, staff, and youth participants from five SFD programs were interviewed. A theoretical model, consisting of the theory of fundamental causes (Link & Phelan, 1995), the classification of SFD programs (Coalter, 2007), and the ecological model of health promotion (McLeroy, 1988), was developed to guide this study.

Interviews were transcribed and then analyzed using a deductive coding process (Gilgun, 2005). The findings revealed that the SFD programs …

Women In Music: Letting A Long Story Be Long Contemplating Women’S Sonic, Musical, And Spiritual Experiences In Prehistory, Deborah J. Saidel

Theses and Dissertations

Situated within deep history, this study explores the auditory and spiritual lives of Paleolithic women. It considers their personal agency in mediating the spiritual power of sound and how doing so contributes to a multifaceted musicality. The theoretical framework involves a wide spectrum of topics, from ways of rethinking the writing of history and reckoning with time, to sound studies and the study of acoustics in ancient sites, to a critical examination through a feminist lens of normative disciplinary scholarship in anthropology and archaeology, religious studies, and musicology. I explore potential audio-visual-lithic relationships for their implications for deepening an understanding …

Examination Of The Role Of Dehumanization As A Potential Mechanism Underlying The Racial Disparities In School Disciplinary Measures., Ebony A. Lambert

Theses and Dissertations

Schools should be safe and supportive spaces for all students, yet Black students tend to face biased treatment in the education system, which often results in harsh disciplinary measures. This research examined the role of animalistic dehumanization (i.e., perceiving others as animal-like and uncultured and denying uniquely human characteristics), in predicting choice of harsher disciplinary measures for Black students as opposed to White students. It was hypothesized that individuals who dehumanize Black students to a greater degree would be more likely to believe that Black students need to be disciplined through harsher measures. Additionally, it was hypothesized that the link …

Red-Headed Woodpecker Full Annual Cycle Ecology At Fort A.P. Hill, Virginia, Benjamin Nickley

Theses and Dissertations

The red-headed woodpecker is a primary cavity excavator found throughout the Eastern Deciduous Forest and parts of the Great Plains. Although widespread, the red-headed woodpecker is generally considered uncommon, with patchily distributed populations. Over the past 50 years, this species has experienced precipitous, range-wide declines. The red-headed woodpecker uses a variety of cover types to meet resource needs across the annual cycle, ranging from oak savannas and wetlands, to mature beech forests and urban parks. Given their apparent adaptability to such a wide range of habitats, causes of declines are perplexing. To understand and stem declines, recent studies have focused …

Shared Genetic And Environmental Influences On Fear, Anxiety, Posttraumatic Stress, And Brain Morphometry, Chelsea Sawyers

Theses and Dissertations

Anxiety disorders (ADs) and stress-related disorders are some of the most common psychiatric disorders in the United States. Like other c0mplex psychiatric illness, genetics and neuroimaging research has focused on understanding their underlying neurobiology. Areas within the fear-network play important roles in threat perception, fear conditioning/learning, cognitive processing, and modulation of fear responses including contextual modulation and extinction and have been implicated in ADs as well as stress disorders such as posttraumatic stress disorder (PTSD). The primary gap in the current search for underlying biological mechanisms is in whether biomarkers associated with disorders share genetic influences with the disorders they …

Mechanisms Of B-Myb Oncogenicity In Ovarian Cancer, Audra N. Iness

Theses and Dissertations

High expression of B-Myb (encoded by MYBL2), an oncogenic transcription factor, is associated with cell cycle deregulation and poor prognosis in several cancers, including ovarian cancer. However, the mechanism by which B-Myb alters the cell cycle is not fully understood. In proliferating cells, B-Myb interacts with the MuvB core complex including LIN9, LIN37, LIN52, RBBP4, and LIN54, forming the MMB (Myb-MuvB) complex, and promotes transcription of genes required for mitosis. Alternatively, the MuvB core interacts with Rb-like protein p130 and E2F4-DP1 to form the DREAM complex that mediates global repression of cell cycle genes in G0/G1, including a subset …

5-Ht2b Receptor-Mediated Cardiac Valvulopathy, Pallavi Nistala

Theses and Dissertations

5-HT_2B receptor agonism causes cardiac valvulopathy, a condition characterized by thickening of the heart valves and as a result, regurgitation of blood within the heart. The anti-obesity drug fenfluramine, which was originally prescribed as an anorectic, was withdrawn from the market due to causing cardiac valvulopathy. Fenfluramine, after metabolism by N-dealkylation, produces the metabolite norfenfluramine, which acts as a more potent valvulopathogen. The same was seen with MDMA (ecstasy), a popular drug of abuse, which is metabolized by N-dealkylation to produce MDA, a more potent valvulopathogen. Glennon and co-workers. studied a series of 2,5-dimethoxy-4- substituted phenylisopropylamines (DOX type) hallucinogens …

Decellularized Matrices Effect On The Adaptive Immune Response, Kegan Sowers

Theses and Dissertations

Decellularized extracellular matrices have been a growing area of interest in the biomedical engineering fields of tissue engineering and regenerative medicine.As these materials move toward clinical applications, the immune response to these materials will be a driving force toward their success in clinical approaches. Fully digested decellularized matrix constructs derived from porcine liver, muscle and lung were created to test the adaptive immune response. Hydrogel characterization ensured that the materials had relatively similar stiffness levels to reduce variability, and in vitro studies were conducted. Each individual construct as well as a gelatin control were plated with a co-culture of macrophages …

Effective Inclusion Practices For The Academic And Social Success Of Students With Intellectual Disabilities, Caitlin J. Siems

All Electronic Theses and Dissertations

This paper includes a comprehensive literature review of the research and best practice implications for providing effective inclusion in the general education setting to individuals with intellectual disabilities. Similarly, it reviews the relevant research regarding effective inclusive practices in adaptive sports, unified programs, and extracurricular activities. The review seeks to answer questions regarding the impact inclusion has on the self-concept and adaptive behaviors of individuals with intellectual; disabilities and their typical functioning peers. The paper provides insights for best practice for educators and information regarding effective frameworks for inclusion in the classroom. Instructional and whole school models that include the …

Factors Contributing To School Placement For Students With Emotional Behavioral Disorders, Colleen F. Weis

All Electronic Theses and Dissertations

Students with Emotional Behavioral Disorders, in combination with significant and chronic behaviors, are often placed in alternative educational settings. No clear rationale is used by school districts to determine educational placement, and schools rely on a variety of settings to provide instruction and services to students with disabilities. The purpose of this qualitative study was to explore the narrative regarding student placement in restrictive settings and the individual and institutional rationales for student transitions. It also studied the narratives supporting students’ return to a less restrictive educational placement. Participants were school district representatives in one Minnesota county who served on …

The Pros And Cons Of Inclusion For Students With Autism Spectrum Disorder (Asd) In The Mainstream Classroom, Benjamin Kwofie

All Electronic Theses and Dissertations

General education placement are believed to offer innumerable benefits for students with Autism Spectrum Disorder (ASD), however, decisions about including students with ASD remain controversial. This thesis highlights the benefits and challenges of including students with ASD in the mainstream setting. Inclusion represents the belief or philosophy that students with disabilities should be integrated into the regular education classroom with the relevant support to enable them to succeed. ASD is a very complicated disability; there are various levels of ability a student with ASD may have and there are also many types of this disorder. There are several effective strategies …

Troubled Water: Building A Bridge To Clean Energy Through Small Hydropower Regulatory Reform, Samuel J. Panarella

Faculty Law Review Articles

This Article is presented in four Parts. Part II outlines the history of hydropower regulation in the U.S., including the environmental, geographic, and human effects of big dam hydropower development that ultimately engendered the onerous regulations currently governing all hydropower development. Building off of this history, Part III discusses America’s hydropower potential, the available methods for tapping it, and the possible environmental impacts of these methods. Part IV provides an overview of the current regulations governing small hydropower. Part V concludes by proposing areas where the regulatory framework for low-impact small hydropower should be reformed to properly and responsibly encourage …

Satellite Sensor Requirements For Monitoring Essential Biodiversity Variables Of Coastal Ecosystems, Frank E. Muller-Karger

Marine Science Faculty Publications

The biodiversity and high productivity of coastal terrestrial and aquatic habitats are the foundation for important benefits to human societies around the world. These globally distributed habitats need frequent and broad systematic assessments, but field surveys only cover a small fraction of these areas. Satellite-based sensors can repeatedly record the visible and near-infrared reflectance spectra that contain the absorption, scattering, and fluorescence signatures of functional phytoplankton groups, colored dissolved matter, and particulate matter near the surface ocean, and of biologically structured habitats (floating and emergent vegetation, benthic habitats like coral, seagrass, and algae). These measures can be incorporated into Essential …

Storm Surge Reconstruction And Return Water Level Estimation In Southeast Asia For The 20th Century, Alba Cid, Thomas Wahl, Don P. Chambers, Sanne Muis

Marine Science Faculty Publications

We present a methodology to reconstruct the daily maximum storm surge levels, obtained from tide gauges, based on the surrounding atmospheric conditions from an atmospheric reanalysis (20th Century Reanalysis—20CR). Tide gauge records in Southeast Asia are relatively short, so this area is often underrepresented in studies based on long observational records, and there are just a few studies that have analyzed storm surge trends, variability or return water levels (RWLs) from numerical models in this area. Here we develop, calibrate, and validate a multivariate linear regression model that relates the storm surge with the principal components of the local atmospheric …

Unprecedented Diversity Of Ssdna Phages From The Family Microviridae Detected Within The Gut Of A Protochordate Model Organism (Ciona Robusta), Alexandria Creasy, Karyna Rosario, Brittany A. Leigh

Marine Science Faculty Publications

Phages (viruses that infect bacteria) play important roles in the gut ecosystem through infection of bacterial hosts, yet the gut virome remains poorly characterized. Mammalian gut viromes are dominated by double-stranded DNA (dsDNA) phages belonging to the order Caudovirales and single-stranded DNA (ssDNA) phages belonging to the family Microviridae. Since the relative proportion of each of these phage groups appears to correlate with age and health status in humans, it is critical to understand both ssDNA and dsDNA phages in the gut. Building upon prior research describing dsDNA viruses in the gut of Ciona robusta, a marine invertebrate model system …

The Paradox Of Competition: Power, Markets, And Money - Who Gets What, When, How?, Martin Shubik

Cowles Foundation Discussion Papers

Money is a mystery and financial institutions are often regarded as guardians and promoters of the mystery. These sketches are designed to help any reader interested in, but not technically trained in economics, understand markets, money, credit and the evolution of a mass market system set in the rich context of its political environment and society. We all want a good society. What is a good society is given by our joint vision, mutual respect and social concern but the implementation of the vision calls for the use and understanding of money, markets and finance. The efficient functioning of a …

Taxonomy And Secondary Metabolites Of Selected Endophytic Actinomycete Strains, Nattakorn Kuncharoen

Chulalongkorn University Theses and Dissertations (Chula ETD)

A total of 50 endophytic actinomycetes isolated from fourteen plant species collected from six provinces of Thailand including Bangkok, Chachoengsao, Chiang Mai, Nakhon Pathom, Prachinburi and Suphan Buri were taxonomically studied relied on their phenotypic and chemotaxonomic characteristics, and the 16S rRNA gene sequence analysis. The isolates were identified as members of the family Streptomycetaceae involving Streptomyces (22 isolates), and the family Micromonosporaceae including Micromonospora (25 isolates), Plantactinospora (1 isolate) and Polymorphospora (1 isolate). Based on phenotypic characteristics, whole genome sequence analysis and DNA-DNA hybridization, 5 novel actinomycete species were proposed consisting of Micromonospora globbae (strain WPS1-2T), Micromonospora azadirachtae (strain …

Taxonomy And Secondary Metabolites Of Selected Endophytic Actinomycete Strains, Nattakorn Kuncharoen

Chulalongkorn University Theses and Dissertations (Chula ETD)

A total of 50 endophytic actinomycetes isolated from fourteen plant species collected from six provinces of Thailand including Bangkok, Chachoengsao, Chiang Mai, Nakhon Pathom, Prachinburi and Suphan Buri were taxonomically studied relied on their phenotypic and chemotaxonomic characteristics, and the 16S rRNA gene sequence analysis. The isolates were identified as members of the family Streptomycetaceae involving Streptomyces (22 isolates), and the family Micromonosporaceae including Micromonospora (25 isolates), Plantactinospora (1 isolate) and Polymorphospora (1 isolate). Based on phenotypic characteristics, whole genome sequence analysis and DNA-DNA hybridization, 5 novel actinomycete species were proposed consisting of Micromonospora globbae (strain WPS1-2T), Micromonospora azadirachtae (strain …

Fighting The Heat: Geoengineering Strategies And Potential Global Effects, Rachael Branscomb

The Synapse: Intercollegiate science magazine

No abstract provided.

The Synapse 18

The Synapse: Intercollegiate science magazine

No abstract provided.

Differential Presentation And Survival Of De Novo And Recurrent Metastatic Breast Cancer Over Time: 1990-2010., Judith A Malmgren, Musa Mayer, Mary K Atwood, Henry G Kaplan

Articles, Abstracts, and Reports

BACKGROUND: Differences in de novo (dnMBC) and recurrent metastatic breast cancer (rMBC) presentation and survival over time have not been adequately described.

METHODS: A retrospective cohort study, 1990-2010, with follow up through 2015 of dnMBC patients (stage IV at diagnosis) and rMBC patients with subsequent distant metastatic recurrence (stage I-III initial diagnosis) [dnMBC = 247, rMBC = 911)]. Analysis included Chi squared tests of categorical variables, Kaplan-Meier survival estimates, and Cox proportional adjusted hazard ratios (HzR) and 95% confidence intervals (CI). Disease specific survival (DSS) was time from diagnosis or distant recurrence to BC death.

RESULTS: Over time, 1990-1998, 1999-2004, …

Tissue Specific Origin, Development, And Pathological Perspectives Of Pericytes., Tomoko Yamazaki, Yoh-Suke Mukouyama

Articles, Abstracts, and Reports

Pericytes are mural cells surrounding blood vessels, adjacent to endothelial cells. Pericytes play critical roles in maturation and maintenance of vascular branching morphogenesis. In the central nervous system (CNS), pericytes are necessary for the formation and regulation of the blood-brain barrier (BBB) and pericyte deficiency accompanies CNS diseases including multiple sclerosis, diabetic retinopathy, neonatal intraventricular hemorrhage, and neurodegenerative disorders. Despite the importance of pericytes, their developmental origins and phenotypic diversity remain incompletely understood. Pericytes express multiple markers and the origin of pericytes differs by tissue, which may cause difficulty for the identification and understanding of the ontogeny of pericytes. Also, …

Copley Library Annual Report 2017-2018, Helen K. And James S. Copley Library, University Of San Diego

Copley Library Annual Reports

Message From the Dean; New School Tours and Outreach Activities; Black Women of NASA Event Draws Crowd to Copley; Faculty Favorites Book Display for National Library Week; Black History Month Collaboration; Student Assistants Present at Creative Collaborations; Digital USD Continues to Grow and Flourish; Copley Joins Online Archive of California; Archives/Special Collections Update; Exhibits Inside and Outside Copley Library; Collections, Access and Discovery Department Update; Textbook Accessibility Task Force; Textbook Reserve Program Partnership; Copley Library Supports Open Education; Digital Initiatives Symposium Celebrates Five Years; Student Assistants 2017-18; 2017-18 Library Faculty Scholarship; Copley Library Stats; 2017-18 Print Lending and Borrowing by …