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A Mechanistic Computational Model Reveals That Plasticity Of Cd4+ T Cell Differentiation Is A Function Of Cytokine Composition And Dosage, Bhanwar Lal Puniya, Robert G. Todd, Akram Mohammed, Deborah M. Brown, Matteo Barberis, Tomáš Helikar

Department of Biochemistry: Faculty Publications

CD4+ T cells provide cell-mediated immunity in response to various antigens. During an immune response, naïve CD4+ T cells differentiate into specialized effector T helper (Th1, Th2, and Th17) cells and induced regulatory (iTreg) cells based on a cytokine milieu. In recent studies, complex phenotypes resembling more than one classical T cell lineage have been experimentally observed. Herein, we sought to characterize the capacity of T cell differentiation in response to the complex extracellular environment. We constructed a comprehensive mechanistic (logical) computational model of the signal transduction that regulates T cell differentiation. The model’s dynamics were characterized and analyzed under …

Reactive Oxygen Species In Chronic Obstructive Pulmonary Disease, Samia Boukhenouna, Mark A. Wilson, Karim Bahmed, Beata Kosmider

Department of Biochemistry: Faculty Publications

Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis and emphysema. Environmental exposure, primarily cigarette smoking, can cause high oxidative stress and is the main factor of COPD development. Cigarette smoke also contributes to the imbalance of oxidant/antioxidant due to exogenous reactive oxygen species (ROS). Moreover, endogenously released ROS during the inflammatory process and mitochondrial dysfunction may contribute to this disease progression. ROS and reactive nitrogen species (RNS) can oxidize different biomolecules such as DNA, proteins, and lipids leading to epithelial cell injury and death. Various detoxifying enzymes and antioxidant defense systems can be involved in ROS removal. In this review, …

Genes For Membrane Transport Proteins: Not So Rare In Viruses, Timo Greiner, Anna Moroni, James L. Van Etten, Gerhard Thiel

James Van Etten Publications

Some viruses have genes encoding proteins with membrane transport functions. It is unknown if these types of proteins are rare or are common in viruses. In particular, the evolutionary origin of some of the viral genes is obscure, where other viral proteins have homologs in prokaryotic and eukaryotic organisms. We searched virus genomes in databases looking for transmembrane proteins with possible transport function. This effort led to the detection of 18 different types of putative membrane transport proteins indicating that they are not a rarity in viral genomes. The most abundant proteins are K+ channels. Their predicted structures vary between …

Size-Dependent Catalysis Of Chlorovirus Population Growth By A Messy Feeding Predator, John Delong, Zeina Al-Ameeli, Shelby Lyon, James L. Van Etten, David Dunigan

James Van Etten Publications

Many chloroviruses replicate in endosymbiotic zoochlorellae that are protected from infection by their symbiotic host. To reach the high virus concentrations that often occur in natural systems, a mechanism is needed to release zoochlorellae from their hosts. We demonstrate that the ciliate predator Didinium nasutum foraging on zoochlorellae-bearing Paramecium bursaria can release live zoochlorellae from the ruptured prey cell that can then be infected by chloroviruses. The catalysis process is very effective, yielding roughly 95% of the theoretical infectious virus yield as determined by sonication of P. bursaria. Chlorovirus activation is more effective with smaller Didinia, as larger …

Fate Of Methoprene In Temperate Salt Marsh Ditches Following Aerial Applications, David J. Tonjes, Anne E. Mcelroy, Robin K. Barnes, Dominick V. Ninivaggi, Walter Dawydiak, Gregory T. Greene, Bruce J. Brownawell

Technology & Society Faculty Publications

Aerial applications of liquid methoprene are used in salt marshes to control mosquitoes by preventing adult emergence. Despite concern about toxicity to non-target organisms, little is known about environmental concentrations after applications, nor methoprene's persistence in salt marsh environments. Aqueous and sediment samples were collected from two marshes receiving weekly applications. Aqueous samples were collected as early as 30 minutes after applications and as long as nine days afterwards; sediment samples were taken within hours of application and as long as 19 days post-application. Use of time-of-flight liquid chromatography – mass spectral analysis allowed for ultra low detection limits (0.5 …

Implementing Climate Change Research At Universities: Barriers, Potential And Actions, Walter Leal Filho, Edward A. Morgan, Eric S. Godoy, Ulisses M. Azeiteiro, Paula Bacelar-Nicolau, Lucas Veiga Ávila, Claudia Mac-Lean, Jean Hugé

Faculty Publications - Philosophy

Many universities around the world have been active centres of climate change research. However, there are a number of barriers to climate change research, stemming both from the nature of the research and the structure of institutions. This paper offers an overview of the barriers which hinder the handling of matters related to climate change at institutions of higher education (IHEs), and reports on an empirical study to investigate these barriers using a global survey of higher education institutions. It concludes by proposing some steps which could be followed with a view to making climate change more present and effective …

Western Michigan University Undergraduate Catalog 2018-2019, Western Michigan University

Western Michigan University Course Catalogs (1904-present)

• General Information
• Colleges
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Western Michigan University Magazine, Research Edition 2018, Western Michigan University

Western Michigan University Magazine (1997-present)

• Future leaders in research start here Guided by world-class faculty scholars, WMU students are engaged in research that adds new knowledge and unique value to the world.

• On the edge of the unknown Biologists and their students are studying the communication habits of field sparrows, a species declining in its range.

• Urban living: An avian refuge? Cities may offer an unexpected oasis for some songbirds.

• The sitting specialists A WMU engineering lab’s specialties include ergonomics as well as product design and evaluation.

• Climate change and construction challenges Experts in the Georgeau Center study ways to build better in the face …

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2018 Warbler, Eastern Illinois University

The Warbler

The 2018 Warbler, yearbook of Eastern Illinois University.

Evolutionary Theory And Criminology, Anthony Walsh, Cody Jorgensen

Criminal Justice Faculty Publications and Presentations

In this chapter, we (a) demonstrate the relevance of evolutionary theory to criminology, (b) discuss the evolutionary origins of both prosocial and antisocial traits, and (c) show that evolutionary theory is invaluable to understanding two key issues that have been impervious to solution using the standard social science model—the sex ratio in criminal offending and the age-crime curve.

Low/Non-Fat Dairy: Summary, Children's Mercy Kansas City

Clinical Critically Appraised Topics

No abstract provided.

Influence Of Kernel Shape And Size On The Packing Ratio And Compressibility Of Hard Red Winter Wheat, Marvin C. Petingco, Mark E. Casada, Ronaldo G. Maghirang, Sidney A. Thompson, Samuel G. Mcneill, Michael D. Montross, Aaron P. Turner

Research and Education Center at Princeton Faculty Publications

Grain compaction occurs during bin storage, and its determination is important for the grain mass estimation needed for inventory and auditing. The degree of compaction is dependent on grain type, bin type, moisture content, amount of grain, initial grain bulk density, coefficients of friction, lateral-to-vertical pressure coefficient, and variation in kernel size. Previous studies have correlated several of these parameters, such as bulk density and grain packing, with moisture content. This study investigated the influence of wheat kernel shape and size distribution on packing ratio and compressibility. Two dockage-free hard red winter (HRW) wheat samples, with no shrunken or broken …

Kentucky Soil Atlas, Anastasios D. Karathanasis, Usda Natural Resources And Conservation Service

Plant and Soil Sciences Faculty Book Gallery

From preface:

Kentucky has a diverse array of geologic, topographic, physiographic, ecological, and aquatic features that have contributed to the development and present characteristics and productivity of the soils in the state. This Soil Atlas has been prepared as an aid to further the knowledge of soils in our state and provide a basic exposure of Kentucky’s soil resources to educators, students, natural resource planners, policy makers, citizens and visitors. The objective of the publication is to present the prominent characteristics of representative soils and how they may affect soil use and management. The Atlas is meant to give a …

Ictv Virus Taxonomy Profile: Chrysoviridae, Said A. Ghabrial, José R. Castón, Robert H. A. Coutts, Bradley I. Hillman, Daohong Jiang, Dae-Hyun Kim, Hiromitsu Moriyama, Ictv Report Consortium

Plant Pathology Faculty Publications

The Chrysoviridae is a family of small, isometric, non-enveloped viruses (40 nm in diameter) with segmented dsRNA genomes (typically four segments). The genome segments are individually encapsidated and together comprise 11.5–12.8 kbp. The single genus Chrysovirus includes nine species. Chrysoviruses lack an extracellular phase to their life cycle; they are transmitted via intracellular routes within an individual during hyphal growth, in asexual or sexual spores, or between individuals via hyphal anastomosis. There are no known natural vectors for chrysoviruses. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Chrysoviridae, which …

Ictv Virus Taxonomy Profile: Partitiviridae, Eeva J. Vainio, Sotaro Chiba, Said A. Ghabrial, Edgar Maiss, Marilyn Roossinck, Sead Sabanadzovic, Nobuhiro Suzuki, Jiatao Xie, Max Nibert, Ictv Report Consortium

Plant Pathology Faculty Publications

The Partitiviridae is a family of small, isometric, non-enveloped viruses with bisegmented double-stranded (ds) RNA genomes of 3–4.8 kbp. The two genome segments are individually encapsidated. The family has five genera, with characteristic hosts for members of each genus: either plants or fungi for genera Alphapartitivirus and Betapartitivirus, fungi for genus Gammapartitivirus, plants for genus Deltapartitivirus and protozoa for genus Cryspovirus. Partitiviruses are transmitted intracellularly via seeds (plants), oocysts (protozoa) or hyphal anastomosis, cell division and sporogenesis (fungi); there are no known natural vectors. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) …

Hydrogen Bonds In Crystalline D-Alanine: Diffraction And Spectroscopic Evidence For Differences Between Enantiomers, Ezequiel A. Belo, Jose E. M. Pereira, Paulo T. Freire, Dimitri N. Argyriou, Juergen Eckert, Heloisa N Bordallo

Chemistry Faculty Publications

Enantiomeric amino acids have specific physiological functions in complex biological systems. Systematic studies focusing on the solid-state properties of D-amino acids are, however, still limited. To shed light on this field, structural and spectroscopic studies of D-alanine using neutron powder diffraction, polarized Raman scattering and ab initio calculations of harmonic vibrational frequencies were carried out. Clear changes in the number of vibrational modes are observed as a function of temperature, which can be directly connected to variations of the N—D bond lengths. These results reveal dissimilarities in the structural properties of D-alanine compared with L-alanine.

Inhibition Of Atypical Protein Kinase C‑Ι Effectively Reduces The Malignancy Of Prostate Cancer Cells By Downregulating The Nf-Κb Signaling Cascade, André H. Apostolatos, Wishrawana Sarathi Bandara Ratnayake, Hla Win-Piazza, Christopher A. Apostolatos, Tracess Smalley, Loveleen Kang, Raoul Salup, Robert Hill, Mildred Acevedo-Duncan

Chemistry Faculty Publications

Prostate cancer (PC) is the most common type of cancer among men. Aggressive and metastatic PC results in lifethreatening tumors, and represents one of the leading causes of mortality in men. Previous studies of atypical protein kinase C isoforms (aPKCs) have highlighted its role in the survival of cultured prostate cells via the nuclear factor (NF)-κB pathway. The present study showed that PKC-ι was overexpressed in PC samples collected from cancer patients but not in non-invasive prostate tissues, indicating PKC-ι as a possible prognostic biomarker for the progression of prostate carcinogenesis. Immunohistochemical staining further confirmed the association between PKC-ι and …

Development And Use Of A Construct Map Framework To Support Teaching And Assessment Of Noncovalent Interactions In A Biochemical Context, Jennifer Loertscher, Jennifer E. Lewis, Allison C. Mercer, Vicky Minderhout

Chemistry Faculty Publications

Most chemistry educators agree that deep understanding of the nature of noncovalent interactions is essential for learning in chemistry. Yet decades of research have shown that students have persistent incorrect ideas about these interactions. We have worked in collaboration with a community of chemistry, biology, and biochemistry educators to develop a construct map to guide development of instructional and assessment resources related to the physical basis of noncovalent interactions in a biochemical context. This map was devised using data about student learning and expert perspectives on noncovalent interactions, resulting in a framework that provides a detailed roadmap for teaching and …

Cgas Drives Noncanonical-Inflammasome Activation In Age-Related Macular Degeneration, Nagaraj Kerur, Shinichi Fukuda, Daipayan Banerjee, Younghee Kim, Dongxu Fu, Ivana Apicella, Akhil Varshney, Reo Yasuma, Benjamin J. Fowler, Elmira Baghdasaryan, Kenneth M. Marion, Xiwen Huang, Tetsuhiro Yasuma, Yoshio Hirano, Vlad Serbulea, Meenakshi Ambati, Vidya L. Ambati, Yuji Kajiwara, Kameshwari Ambati, Shuichiro Hirahara, Ana Bastos-Carvalho, Yuichiro Ogura, Hiroko Terasaki, Tetsuro Oshika, Kyung Bo Kim, David R. Hinton, Norbert Leitinger, John C. Cambier, Joseph D. Buxbaum, M. Cristina Kenney, Bradley D. Gelfand, Jayakrishna Ambati

Ophthalmology and Visual Science Faculty Publications

Geographic atrophy is a blinding form of age-related macular degeneration characterized by retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency, resultant accumulation of endogenous Alu-retroelement RNA, and NLRP3-inflammasome activation. How the inflammasome is activated in this untreatable disease is largely unknown. Here we demonstrate that RPE degeneration in human-cell-culture and mouse models is driven by a noncanonical-inflammasome pathway that activates caspase-4 (caspase-11 in mice) and caspase-1, and requires cyclic GMP-AMP synthase (cGAS)-dependent interferon-β production and gasdermin D-dependent interleukin-18 secretion. Decreased DICER1 levels or Alu-RNA accumulation triggers cytosolic escape of mitochondrial DNA, which engages cGAS. Moreover, caspase-4, gasdermin …

Kentucky Water Resources Research Institute Annual Technical Report Fy 2017, Kentucky Water Resources Research Institute, University Of Kentucky

KWRRI Annual Technical Reports (USGS’s 104b Grant Program)

The 2017 Annual Technical Report for Kentucky consolidates reporting requirements for the Section 104(b) base grant award into a single document that includes: 1) a synopsis of each student research enhancement project that was conducted during the period, 2) citations for related publications, reports, and presentations, 3) a description of information transfer activities, 4) a summary of student support during the period, and 5) notable awards and achievements.

No funds were requested for general program administration activities. However, travel funds were provided to support the participation of the director and associate director in the annual meeting of the National Institutes …

Kentucky River Watershed Watch: Summary Of 2017 Sampling Results, Kentucky Water Resources Research Institute

Kentucky River Watershed Watch

No abstract provided.

Criminalizing (Poor) Fatherhood, Cortney E. Lollar

Law Faculty Scholarly Articles

States prosecute and incarcerate thousands of fathers every year for failing to pay their child support obligations. Ostensibly, these prosecutions aim to foster the health and well-being of children without requiring the child’s mother to bear the costs of raising the child alone. What may appear on the surface to be a system that balances out inequities is actually a deeply flawed government program—one that promotes criminal recidivism and reinforces the poverty of indigent fathers. Contrary to the common image of a “deadbeat dad” raking in money and staying on the lam to avoid helping a mother raise their child, …

Uk Law Notes, 2018, University Of Kentucky College Of Law

Annual Magazines

No abstract provided.

Where Have All The Falcons Gone? Saker Falcon (Falco Cherrug) Exports In A Global Economy, Paul B. Stretesky, Ruth E. Mckie, Michael J. Lynch, Michael A. Long, Kimberly L. Barrett

Criminology Faculty Publications

Within conservation biology growing evidence of the decline of the Saker falcon (falco cherrug) population has directed attention to the role of the global falcon trade. Here, we examine factors that may explain the global Saker trade using ecological modernization, treadmill of production and unequal ecological exchange as theoretical frameworks. We estimate trends in Saker exports using the most comprehensive measure available – Convention on International Trade in Endangered Species of Wild Fauna and Flora Trade Database. Our analysis employs fixed effects regression techniques to control for unobserved heterogeneity between nations to isolate the most important drivers of …

The Imprint Of Childhood Abuse On Trauma-Related Shame In Adulthood, Joan A. Reid

Criminology Faculty Publications

Research has consistently linked residual trauma-related shame among child sexual abuse (CSA) survivors to sexual revictimization, health risk behaviors, and poorer response to mental health treatment. However, questions remain regarding the imprint of childhood maltreatment on trauma-related shame including which CSA characteristics or types of childhood maltreatment contribute to residual shame in adulthood. Using data drawn from a prospective study of 174 primarily African American women with histories of CSA and a matched comparison group, this study explores whether specific characteristics of CSA (familial CSA, CSA with penetration, force used by CSA perpetrator), repeat sexual victimization in adolescence, childhood physical …

Serious Mental Illness Among Young Adult Women Who Use Drugs In The Club Scene: Co-Occurring Biopsychosocial Factors, Maayan Lawental, Hilary L. Surratt, Mance E. Buttram, Steven P. Kurtz

Community and Family Health Faculty Publications

Young women who regularly attend nightclubs are at risk for numerous health and social consequences, including mental distress, sexual and physical victimization and substance dependence. This paper uses a biopsychosocial framework to examine co-occurring mental health problems, victimization, substance dependence, sexual risk and physical pain among a sample of young women who use drugs (N = 222) in Miami’s club scene. The majority of women were under 24 years old, Hispanic, and identified as heterosexual. Almost all the women reported past 90-day use of alcohol, ecstasy/MDMA, marijuana, cocaine and prescription opioids and benzodiazepines; 32% of women reported being in a …

Continued Turbulence In "Waters Of The United States", William T. Gorton Iii

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Kentucky's Agricultural And Ecological Future: Designing Legal And Policy Initiatives For The Commonwealth To Develop Tomorrow's Foodcrops, John W. Head

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Interpretations Of The Clean Water Act Are As Muddy And Polluted As The Water The Act Seeks To Protect, Lauren Keeler

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Evaluating Blended And Flipped Instruction In Numerical Methods At Multiple Engineering Schools, Renee M. Clark, Autar Kaw, Yingyan Lou, Andrew Scott, Mary Besterfield-Sacre

Mechanical Engineering Faculty Publications

With the literature calling for comparisons among technology-enhanced or active-learning pedagogies, a blended versus flipped instructional comparison was made for numerical methods coursework using three engineering schools with diverse student demographics. This study contributes to needed comparisons of enhanced instructional approaches in STEM and presents a rigorous and adaptable methodology for doing so. Our flipped classroom consisted mostly of in-class active learning, with micro-lectures as needed, and technology used both in and out of class, including for expected pre-class review of new content. Our blended classroom consisted mostly of lecture with some in-class active learning, and technology utilized both in …