Digital Commons Network^™

46_1_Masthead.Pdf, Marine Ornithology

Marine Ornithology

No abstract provided.

Preclinical Pharmacokinetic Evaluation To Facilitate Repurposing Of Tyrosine Kinase Inhibitors Nilotinib And Imatinib As Antiviral Agents, Hari Krishna Ananthula, Scott Parker, Erin Touchette, R. Mark Buller, Gopi Patel, Daniel Kalman, Johanna S. Salzer, Nadia Gallardo-Romero, Victoria Olson, Inger K. Damon, Tessa Moir-Savitz, Larry Sallans, Milton H. Werner, Catherine M.T. Sherwin, Pankaj B. Dasai

Pediatrics Faculty Publications

Background

Several tyrosine kinase inhibitors (TKIs) developed as anti-cancer drugs, also have anti-viral activity due to their ability to disrupt productive replication and dissemination in infected cells. Consequently, such drugs are attractive candidates for “repurposing” as anti-viral agents. However, clinical evaluation of therapeutics against infectious agents associated with high mortality, but low or infrequent incidence, is often unfeasible. The United States Food and Drug Administration formulated the “Animal Rule” to facilitate use of validated animal models for conducting anti-viral efficacy studies.

Methods

To enable such efficacy studies of two clinically approved TKIs, nilotinib, and imatinib, we first conducted comprehensive pharmacokinetic …

A Closer Look At The Items Within Three Measures Of Evolution Acceptance: Analysis Of The Mate, I-Sea, And Gaene As A Single Corpus Of Items, William L. Romine, Amber Todd, Emily M. Walter

Biological Sciences Faculty Publications

Background

Current direct Likert measures for evolution acceptance include the MATE, GAENE, and I-SEA. Pros and cons of each of these instruments have been debated, and yet there is a dearth of research teasing out their similarities and differences when they are used together in a single context beyond the fact that their measures tend to be highly correlated. We administered these to 452 college students in non-major biology classes at two research-intensive universities from the Midwestern and Western United States to investigate the measurement properties of the items within these instruments when combined as a single corpus.

Results

Factor …

Changes In Water Quality Of Grand Lake St. Marys Watershed Following Implementation Of A Distressed Watershed Rules Package, Stephen J. Jacquemin, Laura T. Johnson, Theresa A. Dirksen, Gregory J. Mcglinch

Biological Sciences Faculty Publications

Grand Lake St. Marys watershed has drawn attention over the past decade as water quality issues resulting from nutrient loading have come to the forefront of public opinion, political concern, and scientific study. The objective of this study was to assess long-term changes in water quality (nutrient and sediment concentrations) following the distressed watershed rules package instituted in 2011. Since that time, a variety of rules (e.g., winter manure ban) and best management practices (cover crops, manure storage or transfers, buffers, etc.) have been implemented. We used a general linear model to assess variation in total suspended solids, particulate phosphorus, …

Inside Front Matter, Marine Ornithology

Marine Ornithology

No abstract provided.

Masthead, Marine Ornithology

Marine Ornithology

No abstract provided.

Instruction To Authors, Marine Ornithology

Marine Ornithology

No abstract provided.

The Extension Newsletter, Issue 96, Winter 2018, Wright State University Retirees Association

The Extension Newsletter

An eight page newsletter from the Wright State University's Retirees Association.

Vicarious Retribution In U.S. Public Support For War Against Iraq, Peter Liberman, Linda J. Skitka

Publications and Research

U.S. public anger and desires to avenge the 11 September 2001 terror attacks were redirected toward Iraq partly because of its identity as an Arab and Muslim state. Online panel survey data reveal that citizens who were relatively angry about the terror attacks were more belligerent toward Iraq, and that this effect was strongest among those who perceived Arabs and Muslims in monolithic terms. Angry desires to avenge 9/11 were more persistent for those who saw Arabs and Muslims in that light, and their effects on war support were partially mediated by worsened feelings about Arabs and Muslims in general. …

Inflammation: The Normal Response To Injury An Editorial Of The Natural Healing Qualities, W. Sumner Davis

Walden Faculty and Staff Publications

Aim: We aimed to assess effect of food insecurity in individuals with chronic disease like cardiorenal syndrome on mortality.

College Of Osteopathic Medicine Graduate Programs Entering Class 2018, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

B.B. Behavioral Neuroscience 2018, Nova Southeastern University

CPS Undergraduate Course Catalogs

No abstract provided.

It Wasn’T Us: Reply To Michael Brent, Rick Repetti

Publications and Research

In “Confessions of a Deluded Westerner,” Michael Brent insists no contributions to Buddhist Perspectives on Free Will (Repetti) even address free will because none deploy the criteria for free will that Western (incompatibilist) philosophers identify: the ability to do otherwise under identical conditions, and the ability to have one’s choices be up to oneself. Brent claims the criteria and abilities in that anthology are criteria for intentional action, but not all intentional actions are free. He also insists that Buddhism, ironically, cannot even accept intentional action, because, on his analysis, intentionality requires an agent, which Buddhism rejects. …

It Wasn’T Me: Reply To Karin Meyers, Rick Repetti

Publications and Research

This is my reply to Karin Meyers, “False Friends: Dependent Origination and the Perils of Analogy in Cross-Cultural Philosophy,” in this Symposium. Meyers generally focuses on exegesis of what Early Buddhists said, which reasonably constrains what we may think about them if we are Buddhists. I agree with and find much value in most of her astute analyses, here and elsewhere, so I restrict my reply here to where we disagree, or otherwise seem to be speaking past, or misunderstanding, each other. In this regard, I focus on three of her claims. Meyers argues that (1) Buddhist dependent origination …

Catching Chances: The Movement To Be On The Ground And Research Ready Before An Outbreak, David Brett-Major, James V. Lawler

Journal Articles: Epidemiology

After more than 28,000 Ebola virus disease cases and at least 11,000 deaths in West Africa during the 2014⁻2016 epidemic, the world remains without a licensed vaccine or therapeutic broadly available and demonstrated to alleviate suffering. This deficiency has been felt acutely in the two, short, following years with two Ebola virus outbreaks in the Democratic Republic of Congo (DRC), and a Marburg virus outbreak in Uganda. Despite billions of U.S. dollars invested in developing medical countermeasures for filoviruses in the antecedent decades, resulting in an array of preventative, diagnostic, and therapeutic products, none are available on commercial shelves. This …

A Plain And Precious Part Restored: An Essay Based On Matthew Bates's The Birth Of The Trinity: Jesus, God, And Spirit In New Testament And Early Christian Interpretations Of The Old Testament, Paul Y. Hoskisson

BYU Studies

Once every ten or twenty years, it seems, a book happens on the scene that promises to dislodge a long-held and often beloved paradigm. It is not that the old paradigm is necessarily abandoned, but rather it makes room for a different, equally valid one. The subtitle of The Birth of the Trinity announced such a shift and to my utmost delight delivered on that promise.

A Solution In Search Of A Problem At The Biologics Frontier, Erika Lietzan

Faculty Publications

This short paper comments on Professor Carrier's new article, Biologics: The New Antitrust Frontier. His article makes a profound initial contribution to a new area of scholarship, based on a large body of prior work considering antitrust issues relating to small molecule drugs. But Professor Carrier’s article, like my own forthcoming piece on innovation and competition in the biologics marketplace, is inherently speculative. We are making our best judgments about the nature of a still emerging marketplace and likely conduct in that marketplace, based on our understandings of a new regulatory framework that is itself still emerging, the broader legal …

Escaping The Logic Of Anarchy: A New Model Of Collective Security, Bryan H. Druzin

Cardozo Journal of Conflict Resolution

Past attempts to create collective security, such as the League of Nations and the United Nations, have failed. This article argues that this is because the anarchic structure of the international system does not permit a top-down approach to the problem. It is argued that the solution is to create a collective security model that is bottom-up rather than top-down.

This article proposes a model of collective security that uses positive feedback generated by network effects to trigger the bottom-up emergence of a global collective security organization. Driven by fear and self-interest, weak states join this fledgling organization, increasing its …

Housing And Informal Settlements, Nathalie Jean-Baptiste, Veronica Olivotto, Emma E. Porio, Wilbard Kombe, Antonia Yulo-Loyzaga, Ebru Gencer, Mattia Leone, Oswaldo Lucon, Mussa Natty

Sociology & Anthropology Department Faculty Publications

No abstract provided.

The Role Of Nutrient-Related Genes In Understanding The Saxitoxin Production Of Alexandrium Minutum, Kieng Soon Hii, N.F. Kon, P.T. Lim, Chui Pin Leaw

Research Publications (2016 to 2020)

Alexandrium minutum is a saxitoxins-producring marine dinoflagellate that responsible for paralytic shellfish poisoning (PSP). It is widely distributed in the tropical and temperate waters with various hydrographic regimes. The physiological responses of this species to various macronutrients have been studied intensively, but little is known about the regulating mechanism of nutrient uptakes and their roles in saxitoxin production. The effect of varying levels of nitrogen and phosphorous nutrition on the transcriptional responses of a tropical ribotype of A. minutum was investigated in a laboratory setting. The nutrient-related genes, ammonium transporter (AmAmt1), nitrate transporter (AmNrt2), phosphate transporter (AmPiPT1), nitrate reductase (AmNas), …

The Effect Of Fiber Post Location On Fracture Resistance Of Endodontically Treated Maxillary Premolars, Eshamsul Sulaiman, Nada Alarami, Yuh Ing Wong, Wen Hui Lee, Afaf Al-Haddad

Research Publications (2016 to 2020)

Background. There is no sufficient literature on the effect of post location on endodontically treated premolar teeth with 2 roots. Objectives. The aim of the study was to evaluate the effect of fiber post location on fracture resistance and failure mode of endodontically treated premolars with 2 roots. Material and methods. Fifty extracted maxillary first premolars with 2 roots were divided randomly into 5 groups. Group 1 was comprised of sound teeth, which received only metal crowns (control). Teeth from groups 2, 3, 4, and 5 were decoronated 2 mm above the cementoenamel junction (CEJ) and were endodontically treated. No …

Venom Proteomics And Antivenom Neutralization For The Chinese Eastern Russell’S Viper, Daboia Siamensis From Guangxi And Taiwan, K.Y. Tan, N.H. Tan, C.H. Tan

Research Publications (2016 to 2020)

The eastern Russell's viper (Daboia siamensis) causes primarily hemotoxic envenomation. Applying shotgun proteomic approach, the present study unveiled the protein complexity and geographical variation of eastern D. siamensis venoms originated from Guangxi and Taiwan. The snake venoms from the two geographical locales shared comparable expression of major proteins notwithstanding variability in their toxin proteoforms. More than 90% of total venom proteins belong to the toxin families of Kunitz-type serine protease inhibitor, phospholipase A2, C-type lectin/lectin-like protein, serine protease and metalloproteinase. Daboia siamensis Monovalent Antivenom produced in Taiwan (DsMAV-Taiwan) was immunoreactive toward the Guangxi D. siamensis venom, and effectively neutralized the …

The Effectiveness Of Remineralizing Agents On Dentinal Permeability, Marwah Berkathullah, Mohideen Salihu Farook, Okba Mahmoud

Research Publications (2016 to 2020)

the effectiveness of remineralizing agents in reducing dentine permeability by tubule occlusion using fluid filtration device functioning at 100 cmH(2)O (1.4 psi) pressure and SEM/EDX analysis were evaluated and compared. Seventy (n = 70) dentine discs of 1 +/- 0.2 mm width were prepared from sound permanent human molars. Fifty (n = 50) dentine discs were randomly divided into 5 groups (n =10): Group 1: GC Tooth Mousse Plus (Recaldent GC Corporation Tokyo, Japan), Group 2: Clinpro (TM) White Varnish (3M ESPE, USA), Group 3: Duraphat (R) Varnish (Pharbil Waltrop GmbH, Germany), Group 4: Colgate Sensitive Pro-Relief (TM) dentifrice (Colgate …

3′,4′-Dihydroxyflavonol Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis And Endothelial Dysfunction In Mice, Y.S. Lau, Mohd Rais Mustafa, K.W. Choy, S.M.H. Chan, S. Potocnik, T.P. Herbert, O.L. Woodman

Research Publications (2016 to 2020)

Endoplasmic reticulum (ER) stress has been implicated in the development of hypertension 3 through the induction of endothelial impairment. As 3′,4′-dihydroxyflavonol (DiOHF) 4 reduces vascular injury caused by ischaemia/reperfusion or diabetes, and flavonols have been demonstrated to attenuate ER stress, we investigated whether DiOHF can protect mice from ER stress-induced endothelial dysfunction. Male C57BLK/6 J mice were injected with tunicamycin to induce ER stress in the presence or absence of either DiOHF or tauroursodeoxycholic acid (TUDCA), an inhibitor of ER stress. Tunicamycin elevated blood pressure and impaired endothelium-dependent relaxation. Moreover, in aortae there was evidence of ER stress, oxidative stress …

Acute And Sub-Acute Oral Toxicity Of Dracaena Cinnabari Resin Methanol Extract In Rats, N.A. Al-Afifi, A.M. Alabsi, M.M. Bakri, A. Ramanathan

Research Publications (2016 to 2020)

Background: Dracaena cinnabari (DC) is a perennial tree that located on the Southern coast of Yemen native to the Socotra Island. This tree produces a deep red resin known as the Dragon's blood, the Twobrother's Blood or Damm Alakhwain. The current study performed to evaluate the safety of the DC resin methanol extract after a single or 28 consecutive daily oral administrations. Methods: In assessing the safety of DC resin methanol extract, acute and sub-acute oral toxicity tests performed following OECD guidelines 423 and 407, respectively, with slight modifications. In acute oral toxicity test, DC resin methanol extract administered to …

Amenable Epigenetic Traits Of Dental Pulp Stem Cells Underlie High Capability Of Xeno-Free Episomal Reprogramming, S.T. Chandrabose, S. Sriram, S. Subramanian, S.S. Cheng, W.K. Ong, S. Rozen, N.H. Abu Kasim, S. Sugii

Research Publications (2016 to 2020)

Background: While a shift towards non-viral and animal component-free methods of generating induced pluripotent stem (iPS) cells is preferred for safer clinical applications, there is still a shortage of reliable cell sources and protocols for efficient reprogramming. Methods: Here, we show a robust episomal and xeno-free reprogramming strategy for human iPS generation from dental pulp stem cells (DPSCs) which renders good efficiency (0.19%) over a short time frame (13-18 days). Results: The robustness of DPSCs as starting cells for iPS induction is found due to their exceptional inherent stemness properties, developmental origin from neural crest cells, specification for tissue commitment, …

An In Vitro Potency Assay Using Nicotinic Acetylcholine Receptor Binding Works Well With Antivenoms Against Bungarus Candidus And Naja Naja, K. Ratanabanangkoon, P. Simsiriwong, K. Pruksaphon, K.Y. Tan, B. Chantrathonkul, S. Eursakun, C.H. Tan

Research Publications (2016 to 2020)

In order to facilitate/expedite the production of effective and affordable snake antivenoms, a novel in vitro potency assay was previously developed. The assay is based on an antiserum's ability to bind to postsynaptic neurotoxin (PSNT) and thereby inhibit the PSNT binding to the nicotinic acetylcholine receptor (nAChR). The assay was shown to work well with antiserum against Thai Naja kaouthia which produces predominantly the lethal PSNTs. In this work, the assay is demonstrated to work well with antiserum/antivenom against Bungarus candidus (BC), which also produces lethal presynaptic neurotoxins, as well as antivenom against Sri Lankan Naja naja (NN), which produces …

Elemen Pembentukan Akhlak Dan Moral: Penelitian Terhadap Modul Pengajian Kursus Titas Di Universiti Malaya, Faridah Che Husain, Khairul Hamimah Mohd Jodi, Zawiah Mat, Fakhrul Adabi Abdul Kadir

Research Publications (2016 to 2020)

Pembentukan akhlak dan moral dalam kalangan pelajar merupakan agenda utama dalam aspirasi pendidikan negara. Fenomena kelunturan nilan, akhlak dan moral semakin dirasai apabila melibatkan golongan berpendidikan tinggi. Hal ini berdasarkan pelbagai kes yang dilaporkan oleh akhbar yang melibatkan pelajar di institusi pendidikan tinggi. Antaranya ialah penglibatan pelajar dalam gejala penagihan dadah, menyembunyikan kelahiran dan pembuangan bayi, kesbuli, jenayah bunuh dan sebagainaya. Sehubungan itu, pelaksanaan kursus TITAS di peringkat institusi pengajian tinggi adalah sangat signifikan dan releven dalam konteks dunia hari ini yang semakin mencabar kewibawaan akhlak dan moral manusia. Justeru, artikel ini akan mengupas elemen-elemen pembentukan akhlak dan moral dalam …

Fiber Density Of Collagen Grafts Impacts Rabbit Urethral Regeneration, H.M. Larsson, G. Vythilingam, K. Pinnagoda, E. Vardar, E.M. Engelhardt, S. Sothilingam, R.C. Thambidorai, Tunku Kamarul, J.A. Hubbell, P. Frey

Research Publications (2016 to 2020)

There is a need for efficient and "off-The-shelf" grafts in urethral reconstructive surgery. Currently available surgical techniques require harvesting of grafts from autologous sites, with increased risk of surgical complications and added patient discomfort. Therefore, a cost-effective and cell-free graft with adequate regenerative potential has a great chance to be translated into clinical practice. Tubular cell-free collagen grafts were prepared by varying the collagen density and fiber distribution, thereby creating a polarized low fiber density collagen graft (LD-graft). A uniform, high fiber density collagen graft (HD-graft) was engineered as a control. These two grafts were implanted to bridge a 2 …

Globalisation And The Muslim Ummah: Issues, Challenges, And The Ways Out, Rashid Ating

Research Publications (2016 to 2020)

Globalisation is a phenomenon and a process that is aspiring to transform the entire world into a single political and economic system through the rapid movement of goods and people across the planet in the most rapid speed ever witnessed in the history of mankind. This paper is a theoretical and conceptual research which investigates the dilemmas of the Muslim ummah in the era of globalisation. The problem is the way the global forces are threatening to obliterate all cultures and civilisations in favour for non-conforming Western political and economic arrangements. The research uses a qualitative method of data collection …