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2018

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Neuromuscular Reflex Control For Prostheses And Exoskeletons, Sandra K. Hnat Jan 2018

Neuromuscular Reflex Control For Prostheses And Exoskeletons, Sandra K. Hnat

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Recent powered lower-limb prosthetic and orthotic (P/O) devices aim to restore legged mobility for persons with an amputation or spinal cord injury. Though various control strategies have been proposed for these devices, specifically finite-state impedance controllers, natural gait mechanics are not usually achieved. The goal of this project was to invent a biologically-inspired controller for powered P/O devices. We hypothesize that a more muscle-like actuation system, including spinal reflexes and vestibular feedback, can achieve able-bodied walking and also respond to outside perturbations. The outputs of the Virtual Muscle Reflex (VMR) controller are joint torque commands, sent to the electric motors …

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Synthesis And Biological Evaluation Of Small Molecular Drug Candidates For The Treatment Of Her2 Overexpressed Breast Cancer, Anran Zhao Jan 2018

Synthesis And Biological Evaluation Of Small Molecular Drug Candidates For The Treatment Of Her2 Overexpressed Breast Cancer, Anran Zhao

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In the US breast cancer is the most common cancer after skin cancer. Currently in the US the average risk of a woman to develop breast cancer in her life is roughly 12%. About 25-30% of breast cancer patients have HER2 overexpressed tumor, and the growth of tumor cell is depend on HER2 pathway. It has been well-documented that patients with over-expressed HER2 are associated with increased disease recurrence, worse prognosis and lower survival. Currently there are two type of HER2 targeting drug. The first group is HER2 monoclonal antibody drugs such as trastuzumab approved by FDA in 1998; the …

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Evaluation Of A Small Molecule Agonist Of Epha2 Receptor Tyrosine Kinase And Copalic Acid Analogs As Prostate Cancer Therapeutics, Nethrie Idippily Jan 2018

Evaluation Of A Small Molecule Agonist Of Epha2 Receptor Tyrosine Kinase And Copalic Acid Analogs As Prostate Cancer Therapeutics, Nethrie Idippily

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Project I: Chemotherapeutic drugs have many side effects that are undesirable and are highly toxic. Therefore, there is a growing need for the development of drugs with enhanced efficacy, specificity, and potency to provide cancer patients with a better prognosis. It was discovered that a member of the Receptor Tyrosine Kinase family, EphA2, may prove to be a viable target in developing anti-cancer agents. In the presence of its ligand, EphA2 receptor is responsible for apoptotic and anti-migratory activity. However, in the absence of ligand, EphA2 is able to stimulate cell migration and therefore tumorigenic activity. These conflicting roles of …

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Development Of Bioanalytical Methods For Quantitative Measurement Of Anticancer Agents, Sandeep R. Kunati Jan 2018

Development Of Bioanalytical Methods For Quantitative Measurement Of Anticancer Agents, Sandeep R. Kunati

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The ever-growing need to develop new anticancer agents due to increased incidence of cancer and its recurrence has led to a broad range of investigational efforts in anticancer research. Drug discovery and development processes involve evaluations of pharmacokinetic and pharmacodynamic parameters of potential drug candidates in order to assess their safety, toxicity, and efficacy profiles. By providing sensitivity, assay precision, reliability, and high-throughput, mass spectrometry has become an indispensable tool in quantitative and qualitative analysis, from early-stage drug discovery and development processes to routine laboratory analysis. Development of bioanalytical methods requires knowledge of separation science with instrumentation, data interpretation and …

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A Broadly Tunable Surface Plasmon-Coupled Wavelength Filter For Visible And Near Infrared Hyperspectral Imaging, Ajaykumar Zalavadia Jan 2018

A Broadly Tunable Surface Plasmon-Coupled Wavelength Filter For Visible And Near Infrared Hyperspectral Imaging, Ajaykumar Zalavadia

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Hyperspectral imaging is a set of techniques that has contributed to the study of advanced materials, pharmaceuticals, semiconductors, ceramics, polymers, biological specimens, and geological samples. Its use for remote sensing has advanced our understanding of agriculture, forestry, the Earth, environmental science, and the universe. The development of ultra-compact handheld hyperspectral imagers has been impeded by the scarcity of small widefield tunable wavelength filters. The widefield modality is preferred for handheld imaging applications in which image registration can be performed to counter scene shift caused by irregular user motions that would thwart scanning approaches. In the work presented here an electronically …

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A Synthesis Platform For Temperature Responsive Star Polymers, Schmitt J. Richard Jr. Jan 2018

A Synthesis Platform For Temperature Responsive Star Polymers, Schmitt J. Richard Jr.

ETD Archive

Star polymers are a class of branched polymers comprised of several polymer chains extending from a central point. Star polymers have applications in biopharmaceuticals where they have been proposed to be suitable drug delivery vehicles. Star polymers have traditionally been synthesized through chemical synthesis with added functionality provided by grafting on the arms. This complex synthesis can be simplified by using a biosynthetic approach which enables precise control of molecular weight and composition. This approach is demonstrated using star polymers with arms composed of a temperature responsive protein-based polymer termed elastin-like polypeptide (ELP). Star polymers are characterized based on the …

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Real-Time Assessment And Visual Feedback For Patient Rehabilitation Using Inertial Sensors, Deepa Adinarayanan Jan 2018

Real-Time Assessment And Visual Feedback For Patient Rehabilitation Using Inertial Sensors, Deepa Adinarayanan

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Rehabilitation exercises needs have been continuously increasing and have been projected to increase in future as well based on its demand for aging population, recovering from surgery, injury and illness and the living and working lifestyle of the people. This research aims to tackle one of the most critical issues faced by the exercise administers-Adherence or Non-Adherence to Home Exercise problems especially has been a significant issue resulting in extensive research on the psychological analysis of people involved. In this research, a solution is provided to increase the adherence of such programs through an automated real-time assessment with constant visual …

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Stabilization Of Hypoxia Inducible Factor By Cobalt Chloride Can Alter Renal Transepithelial, Subhra Sankar Nag Jan 2018

Stabilization Of Hypoxia Inducible Factor By Cobalt Chloride Can Alter Renal Transepithelial, Subhra Sankar Nag

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Kidney cyst expansion, stagnant fluid accumulation, and insufficient vascular supply can result in localized chronic ischemia-hypoxia in kidney cysts, as well as in normal renal epithelia adjacent to a cyst. We hypothesize that in normal epithelia near a cyst, the stabilization of Hypoxia Inducible Factor 1a (HIF1a), a major regulator of cellular response to hypoxia, can cause altered paracellular and transcellular transport, transforming a normal absorptive phenotype to a secretory and paracellularly leaky phenotype, leading to cyst expansion. Using 100 µmol/L cobalt chloride (CoCl2), HIF1a was stabilized in cellular nucleus of a mouse cortical collecting duct cell line (mCCD 1296 …

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Does Posture Impact Affective Word Processing? Examining The Role Of Posture Across Adulthood In An Incidental Encoding Task, Lucas John Hamilton Jan 2018

Does Posture Impact Affective Word Processing? Examining The Role Of Posture Across Adulthood In An Incidental Encoding Task, Lucas John Hamilton

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Research in emotional aging has primarily investigated mechanisms that could explain the age-related increase in positive emotionality despite various age-related losses. Of particular note is the increasing importance of age-related positivity effects and underlying biological influences on affective processes. Despite evidence of weakened mind-body connectivity in older adulthood presented in the maturation dualism framework, research shows age-similarities in subjective and objective reactivity for certain negative emotional states across adulthood. Thus, robust physiological-experiential associations may still exist in later life. Investigations of integrated mind-body connectivity have lead researchers to examine the influence of posture on cognitive outcomes. Prior evidence has observed …

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Continuous Human Activity Tracking Over A Large Area With Multiple Kinect Sensors, Akshat C. Hans Jan 2018

Continuous Human Activity Tracking Over A Large Area With Multiple Kinect Sensors, Akshat C. Hans

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In recent years, researchers had been inquisitive about the use of technology to enhance the healthcare and wellness of patients with dementia. Dementia symptoms are associated with the decline in thinking skills and memory severe enough to reduce a person’s ability to pay attention and perform daily activities. Progression of dementia can be assessed by monitoring the daily activities of the patients. This thesis encompasses continuous localization and behavioral analysis of patient’s motion pattern over a wide area indoor living space using multiple calibrated Kinect sensors connected over the network. The skeleton data from all the sensor is transferred to …

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School Logo Cleveland State University Logo Title Evolutionary Optimization For Safe Navigation Of An Autonomous Robot In Cluttered Dynamic Unknown Environments, Arash Roshanineshat Jan 2018

School Logo Cleveland State University Logo Title Evolutionary Optimization For Safe Navigation Of An Autonomous Robot In Cluttered Dynamic Unknown Environments, Arash Roshanineshat

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We present a path planning approach based on probabilistic methods for a robot to navigate in a cluttered, dynamic, unknown environment. There are dynamic obstacles moving around and static obstacles located in the map. The robot does not have any prior information about them but should be able to navigate through the map beginning from a known starting point and safely ending at a known target point. The only information the robot has is the location of the starting point and the target point and it uses sensory information to collect information about its surroundings. Our method is compared to …

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Determination Of Growth Kinetics, Yield Coefficients And Biodiesel Properties For The Green Microalgae Scenedesmus Dimorphus In Freshwater And Saline Medias, Morgan L. Cohara Jan 2018

Determination Of Growth Kinetics, Yield Coefficients And Biodiesel Properties For The Green Microalgae Scenedesmus Dimorphus In Freshwater And Saline Medias, Morgan L. Cohara

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Of the many alternative resources capable of generating biofuel, microalgal oil serves as a promising feedstock. Unfortunately, biodiesel production from microalgae is currently hindered by high operational costs. One primary causes for these high costs is the large quantity of freshwater required for cultivation. This experiment was designed to assess the feasibility of growing the green, freshwater microalgae Scenedesmus dimorphus in an increasingly saline environment. Both average yield coefficients and growth rates were monitored with increasing salt concentration. Determination of average yield coefficients allows for process scale-up and the optimization of production costs by minimizing raw material waste. Salinity was …

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The Naked Mole Rat Possesses A Differently Phased Core Clock System Along With A Different Glucose Handling And Mtor Systems Compared To The Common Lab Mouse, Soumyaditya Ghosh Jan 2018

The Naked Mole Rat Possesses A Differently Phased Core Clock System Along With A Different Glucose Handling And Mtor Systems Compared To The Common Lab Mouse, Soumyaditya Ghosh

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INTRODUCTION The Naked Mole Rat [ Heterocephalus glaber] is a type of rodent -with the highest average lifespan-30 years-among all the rodent species. It lives underground in sealed burrow systems with little to no exposure to day-night transitions on the surface. It shows polyphasic round the clock activity within its subterranean burrow system. The activity and physiology of most animals are governed by the biological circadian clock. The biological circadian clock is a system that oscillates with a rough periodicity of 24 hours. Environmental zeitgebers regulate the entrainment of the circadian clock to the 24-hour day-night cycle and light is …

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Predictive Simulations Of Gait And Their Application In Prosthesis Design, Anne D. Koelewijin Jan 2018

Predictive Simulations Of Gait And Their Application In Prosthesis Design, Anne D. Koelewijin

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Predictive simulations predict human gait by solving a trajectory optimization problem by minimizing energy expenditure. These simulations could predict the effect of a prosthesis on gait before its use. This dissertation has four aims, to show the application of predictive simulations in prosthesis design and to improve the quality of predictive simulations. Aim 1 was to explain joint moment asymmetry in the knee and hip in gait of persons with a transtibial amputation (TTA gait). Predictive simulations showed that an asymmetric gait required less effort. However, a small effort increase yielded a gait with increased joint moment symmetry and reduced …

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Computational Investigation Of Protein Assemblies, Sm Bargeen Alam Turzo Jan 2018

Computational Investigation Of Protein Assemblies, Sm Bargeen Alam Turzo

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Selective nitrosylation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) at Cys-247 affects gene regulation through the interferon-gamma (IFN- γ) activated inhibitor of translation (GAIT) complex. Oxidized low-density lipoprotein (LDLox) and INF-γ induce assembly of the nitrosylase complex composed of inducible nitric oxide synthase (iNOS), S100A8, and S100A9 proteins. Crystal structure of the complex of GAPDH and S100A8A9 is not known, structural prediction method were employed by protein-protein docking and binding energy calculation with PatchDock and FIREDock respectively. Candidate models were selected, based on a weight factor calculated, from the computational method developed from the "artificial protease" cleavage mapping Fe(III) (s)-1-(p- …

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High-Throughput Metabolism-Induced Toxicity Assays On A 384-Pillar Plate, Sooyeion Kang Jan 2018

High-Throughput Metabolism-Induced Toxicity Assays On A 384-Pillar Plate, Sooyeion Kang

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The U.S Environmental Protection Agency (EPA) launched the Transform Tox Testing Challenge in 2016 with the goal of developing practical methods that can be integrated into conventional high-throughput screening (HTS) assays to better predict the toxicity of parent compounds and their metabolites in vivo. In response to this need and to retrofit existing HTS assays for assessing metabolism-induced toxicity of compounds, we have developed a 384-pillar plate that is complementary to traditional 384-well plates and ideally suited for culturing human cells in three dimensions (3D) at a microscale. Briefly, human embryonic kidney (HEK) 293 cells in a mixture of alginate …

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Relationship Between Self-Efficacy And Attitudes Toward Evidence-Based Practice In Psychology, Radinka Jurosevic Samardzic Jan 2018

Relationship Between Self-Efficacy And Attitudes Toward Evidence-Based Practice In Psychology, Radinka Jurosevic Samardzic

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As a result of a fierce debate about the most important factors of effective therapy, the American Psychological Association (APA) defined Evidence-Based Practice in Psychology (EBPP) as “an approach to clinical practice which integrates best available research with clinical expertise in context of patient characteristics, culture, and preferences.” (APA, 2006, p. 273). Research suggests that positive attitudes toward EBPP are related to use of EBPP (Nelson & Steele, 2007). This study utilized a social cognitive theory (Bandura, 1986) framework to examine the relationships between counseling self-efficacy, research self-efficacy, past training experiences, knowledge of EBPP, and attitudes toward EBPP. The participants …

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Atheism And The Effects Of Mortality Salience And Limited Analytic Processing Ability On Religious Faith And Teleological Thinkin, Brett Jordan Waggoner Jan 2018

Atheism And The Effects Of Mortality Salience And Limited Analytic Processing Ability On Religious Faith And Teleological Thinkin, Brett Jordan Waggoner

ETD Archive

The scenario of the atheist in the proverbial foxhole has been a topic of discussion in religious circles for centuries. Building on prior research utilizing terror management theory (TMT), a dual process model of cognition, and previous work suggesting that humans are intuitively wired for teleological and religious concepts, the researchers set out to examine atheist’s religiosity when confronted with the reality of one’s impermanence. To explore this idea, the present experiment recruited a sample of atheists, manipulated their awareness of mortality, manipulated their ability to employ analytic thinking, and measured various intuitive cognitions (e.g., teleological reasoning) alongside religious belief. …

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Are There Differences In Vocal Parameters Across Various Ethnic Groups?, Mason P. Meek Jan 2018

Are There Differences In Vocal Parameters Across Various Ethnic Groups?, Mason P. Meek

ETD Archive

The purpose of this study was to investigate vocal characteristics of various ethnic groups in terms of acoustic, physiological, and perceptual data. Currently there are acoustic parameter norms that have been established for men and women. Prior research suggested that these norms were established on only American Caucasian individuals. This creates the question as to whether or not these norms are reflective of the true nature of vocal fold closure pattern of all ethnic groups. If there is a difference in vocal characteristics then it would be important to establish specific norms for various ethnic groups. Further rationale for this …

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Color Removal From Combined Dye And Fruit Nectar Wastewater Using Adsorption And Microfiltration, Oluwatobiloba A. Akinwande Jan 2018

Color Removal From Combined Dye And Fruit Nectar Wastewater Using Adsorption And Microfiltration, Oluwatobiloba A. Akinwande

ETD Archive

Pollution of the waterways is a great challenge of the 21st century. Textile effluents contain compounds which have the capacity to cause more harm when ingested. There are many dye removal technologies like coagulation, photo oxidation which help to remove color from dye wastewater. The use of adsorption to remove color from dye wastewater has been used for many centuries. Activated carbon can efficiently remove color from dye wastewater but it is very expensive and so different researches have been conducted to get the adsorption capacity of different forms of adsorbents. These adsorbents can be gotten from agricultural waste, biomass, …

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Factors Affecting Minimum Dissolved Oxygen Concentration In Streams, Chistopher Robert Huhnke Jan 2018

Factors Affecting Minimum Dissolved Oxygen Concentration In Streams, Chistopher Robert Huhnke

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Modeling water quality has been shown to be a useful tool in strategizing water quality management. Dissolved oxygen (DO) has one of the largest impacts on water quality compared to other parameters. The purpose of the dissertation research is to generate a regression equation model, using the US EPA QUAL2K model as the base, to determine different factors affecting minimum dissolved oxygen concentrations in streams, to determine the critical distance for the minimum dissolved oxygen concentration, and the magnitude of impact of each parameter. Based on regression analysis, the factors affecting minimum DO in river water are effluent biochemical oxygen …

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Adsorption And Microfiltration Processes To Treat Dye And Coffee Wastewater., Abhiram Siva Prasad Pamula Jan 2018

Adsorption And Microfiltration Processes To Treat Dye And Coffee Wastewater., Abhiram Siva Prasad Pamula

ETD Archive

Wastewater from coffee processing industry creates high biological and chemical oxygen demand in the surface water. In addition to coffee wastewater from coffee industry, dyes from textile industry enter surface water affecting water quality in terms of transmissivity of light. Adsorption is an economical wastewater treatment process to remove color from dye and coffee wastewater. In the current thesis, adsorption using low-cost adsorbents like peanut hull and onion peel are used to treat combined dye and coffee wastewater. Three representative dyes including acid black 48, disperse yellow 3, crystal violet certified with processed coffee is used in preparing batch adsorption …

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The Evaluation Of Non-Standard Accented English: An Intergroup Perspective On Language Attitudes, Doris Acheme Jan 2018

The Evaluation Of Non-Standard Accented English: An Intergroup Perspective On Language Attitudes, Doris Acheme

ETD Archive

The present study used social identity theory as a framework in examining the evaluation of non-standard accented speakers from India and Nigeria and whose first language is English. Social identity theory explains one’s awareness that he/she is a member of a certain social group and that such group membership is of value to the individual. Accordingly, the study investigated how social identity influences listeners’ perceptions of non-standard accented speakers’ status, solidarity, and dynamism. And also, if Standard American English (SAE), Indian and Nigerian accents are perceived differently by listeners. A 3 (SAE, Indian accented English, and Nigerian accented English) ¿ …

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Il-17 Drives Copper Uptake And Activation Of Growth Pathways In Colorectal Cancer Cells In A Steap4-Dependent Manner, Evan Martin Jan 2018

Il-17 Drives Copper Uptake And Activation Of Growth Pathways In Colorectal Cancer Cells In A Steap4-Dependent Manner, Evan Martin

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Colorectal cancer is a disease characterized by abnormal, invasive cell growth beginning in the colon or rectum. The third most common type of cancer worldwide, approximately one million new cases of the disease are diagnosed across the globe annually, resulting in an estimated 700,000+ deaths. One major risk factor associated with development of colorectal cancer is the presence of chronic inflammation in the large intestine, also known as colitis. Inflammation is a complex immune response against harmful stimuli, characterized by symptoms including heat, redness, swelling and pain. One important molecular mediator of this process is interleukin 17 (IL-17), a pro-inflammatory …

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Il-17 Drives Copper Uptake And Activation Of Growth Pathways In Colorectal Cancer Cells In A Steap4-Dependent Manner, Evan Martin Jan 2018

Il-17 Drives Copper Uptake And Activation Of Growth Pathways In Colorectal Cancer Cells In A Steap4-Dependent Manner, Evan Martin

ETD Archive

Colorectal cancer is a disease characterized by abnormal, invasive cell growth beginning in the colon or rectum. The third most common type of cancer worldwide, approximately one million new cases of the disease are diagnosed across the globe annually, resulting in an estimated 700,000+ deaths. One major risk factor associated with development of colorectal cancer is the presence of chronic inflammation in the large intestine, also known as colitis. Inflammation is a complex immune response against harmful stimuli, characterized by symptoms including heat, redness, swelling and pain. One important molecular mediator of this process is interleukin 17 (IL-17), a pro-inflammatory …

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Recognition Memory Revisited: An Aging And Electrophysiological Investigation, Elliot C. Jardin Jan 2018

Recognition Memory Revisited: An Aging And Electrophysiological Investigation, Elliot C. Jardin

ETD Archive

This study provides a better understanding of contributing factors to age differences in human episodic memory. A recurrent finding in recognition memory is that older adults tend to have lower overall accuracy and tend to make fewer false-alarm errors in judging new items, relative miss errors (Coyne, Allen & Wickens, 1986; Danziger, 1980; Poon and Fozard 1980). Two possible causes for decline in these abilities include an age-related decrement in speed of processing (Salthouse 1991) and changes in information processing ability due to entropy (Allen, Kaufman, Smitch, & Propper 1998a; Mallik et al., in preparation). Additionally, age differences may be …

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Fish & Wildlife News: Winter 2018, Matt Trott Jan 2018

Fish & Wildlife News: Winter 2018, Matt Trott

Fish and Wildlife News

No abstract provided.

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Pittsburgh Courier, Msrc Staff Jan 2018

Pittsburgh Courier, Msrc Staff

Manuscript Division Finding Aids

The Papers of the Pittsburgh Courier Washington Bureau span the years 1946-1968 and measure approximately 13 linear feet. The manuscript portion of the collection documents the relationship between the Washington branch and the main office of the Courier in Pittsburgh. Correspondence forms the bulk of this portion and documents the inter-departmental relationships of the Washington Bureau. Primary correspondents include Washington Bureau Chiefs, Levi Jolley and Hugo Warren, as well as Bookkeeper Josephine E. Lowery. Correspondents are listed alphabetically. The remainder of the manuscript portion of the collection includes material documenting the roles of the advertising, circulation, and financial and legal …

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Continuous Practices During Kindergarten Transitions, Nikole Lajuan Turner Logan Jan 2018

Continuous Practices During Kindergarten Transitions, Nikole Lajuan Turner Logan

All Electronic Theses and Dissertations

Although children’s development may be continuous, their early learning experience may not be. Absent from the field is literature describing actual teacher practices that are continued from early learning settings to kindergarten. This quantitative comparison study explored the continuous adult behaviors in two types of childcare early learning environments to determine if these behaviors are continuous, and to what degree, with the adult behaviors exhibited by kindergarten teachers at the time of kindergarten entry. Twenty-one classroom teachers were observed in the areas of physical environment, adult-child interactions, and teaching strategies. Of these classroom teachers, eight were in childcare early learning …

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Unopa Notes, October-November, 2018 Jan 2018

Unopa Notes, October-November, 2018

UNOPA: Newsletters

No abstract provided.

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