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Deciphering The Origin, Evolution, And Physiological Function Of The Subtelomeric Arylalcohol Dehydrogenase Gene Family In The Yeast Saccharomyces Cerevisiae, Dong Dong Yang, Gustavo M. De Billerbeck, Jin Jing Zhang, Frank Rosenzweig, Jean Marie Francois

Biological Sciences Faculty Publications

Homology searches indicate that Saccharomyces cerevisiae strain BY4741 contains seven redundant genes that encode putative aryl-alcohol dehydrogenases (AAD). Yeast AAD genes are located in subtelomeric regions of different chromosomes, and their functional role(s) remain enigmatic. Here, we show that two of these genes, AAD4 and AAD14, encode functional enzymes that reduce aliphatic and aryl-aldehydes concomitant with the oxidation of cofactor NADPH, and that Aad4p and Aad14p exhibit different substrate preference patterns. Other yeast AAD genes are undergoing pseudogenization. The 5' sequence of AAD15 has been deleted from the genome. Repair of an AAD3 missense mutation at the catalytically essential Tyr73 …

Identification Of Novel Mites (Miniature Inverted-Repeat Transposable Elements) In Coxiella Burnetii: Implications For Protein And Small Rna Evolution, Shaun Wachter, Rahul Raghavan, Jenny Wachter, Michael F. Minnick

Biological Sciences Faculty Publications

Background: Coxiella burnetii is a Gram-negative gammaproteobacterium and zoonotic agent of Q fever. C. burnetii’s genome contains an abundance of pseudogenes and numerous selfish genetic elements. MITEs (miniature invertedrepeat transposable elements) are non-autonomous transposons that occur in all domains of life and are thought to be insertion sequences (ISs) that have lost their transposase function. Like most transposable elements (TEs), MITEs are thought to play an active role in evolution by altering gene function and expression through insertion and deletion activities. However, information regarding bacterial MITEs is limited.

Results: We describe two MITE families discovered during research on small non-coding …

Crystal Structure Of The Major Quadruplex Formed In The Promoter Region Of The Human C-Myc Oncogene, Sascha Stump, Tung-Chung Mou, Stephen R. Sprang, Nicholas R. Natale, Howard D. Beall

Biological Sciences Faculty Publications

The c-MYC oncogene mediates multiple tumor cell survival pathways and is dysregulated or overexpressed in the majority of human cancers. The NHE III1 region of the c-MYC promoter forms a DNA quadruplex. Stabilization of this structure with small molecules has been shown to reduce expression of c-MYC, and targeting the c-MYC quadruplex has become an emerging strategy for development of antitumor compounds. Previous solution NMR studies of the c-MYC quadruplex have assigned the major conformer and topology of this important target, however, regions outside the G-quartet core were not as well-defined. Here, we report a high-resolution crystal structure (2.35 Å) …

Superresolved Three-Dimensional Analysis Of The Spatial Arrangement Of The Human Immunodeficiency Virus Type-1 (Hiv-1) Envelope Glycoprotein At Sites Of Viral Assembly, Carmen Anne Buttler

Electronic Theses and Dissertations

Human Immunodeficiency Virus type 1 (HIV-1) replicates by forcing infected host cells to produce new virus particles, which assemble form protein components on the inner leaflet of the host cell's plasma membrane. This involves incorporation of the essential viral envelope glycoprotein (Env) into a structural lattice of viral Gag proteins. The mechanism of Env recruitment and incorporation is not well understood. To better define this process, we seek to describe the timing of Env-Gag encounters during particle assembly by measuring angular positions of Env proteins about the surfaces of budding particles. Using three-dimensional superresolution microscopy, we show that Env distributions …

Living Through Terror And Terror Through Living: The Biopolitical Dimensions Of Religion, Security, And Terrorism, Donnie Featherston

Electronic Theses and Dissertations

Recent emphasis and attention by thinkers, media pundits, and politicians on terrorism requires new, critical evaluation of the processes by which terrorism is understood. By investigating the concept of biopolitics, as developed specifically through Michel Foucault and Giorgio Agamben, new insights into the interactions between terrorism, politics, and religion can emerge. Most notably, the attempts to explain terror as simply an economic problem, an excessive form of violence, and/or as religious fervency gone awry rely on embedded biopolitical concepts. The continual attempts to solve terrorism through increased biopolitical strategies, thereby making terrorism a problem for biopolitics, only further substantiate the …

The Investigation Of Lactoferrin Nitration: Quantification, Function, And Inhibition, Amani Yahya Alhalwani

Electronic Theses and Dissertations

Lactoferrin (LF) is an iron-binding glycoprotein of molecular mass ca. 80 kDa that is predominantly found in mammalian body fluids. Lactoferrin is a multifunctional protein that has a wide range of properties such as antibacterial, antiviral, anti-inflammatory, and anti-allergic functions. Tyrosine residues in the protein play a part in many lactoferrin functions. Protein tyrosine nitration modification represents an oxidative and nitrosative stress process which can be caused by the exposure of proteins to oxidants from air pollution or disease. Understanding the way nitrated lactoferrin interacts with the biochemical environment of the body is thus important to the broader goal of …

Adolescent Protective Factors Related To Resilience: Issues Of Academic Self-Efficacy, Parental Involvement, And Special Education Status, Bethdalie Cruz

Electronic Theses and Dissertations

The predictive value of three constructs was examined in this study in order to explain adolescent self-reported protective factors associated with resilience while moderating for the effects of sex and race. The three constructs included Academic Self-efficacy, Maternal Parental Involvement, and Special Education Identification Status. Participants included 54 adolescents in diverse public middle and high schools, ages 11 to 18. Twenty of these participants were identified as receiving special education services while 34 did not. Results indicated that adolescent perceptions of Academic Self-efficacy significantly predicted protective factors associated with resilience while Special Education Identification Status and Maternal Parental Involvement did …

What Drives Species Richness In Colorado's Alpine Tundra, Michael Kintgen

Regis University Student Publications (comprehensive collection)

Despite years of research, drivers of vascular plant species richness in Colorado’s alpine tundra habitats are largely unknown. Factors such as slope aspect, Pleistocene glaciation, nutrient levels, latitude and longitude, snow depth, and disturbance have been studied. Despite this research, few patterns have emerged. Research in Colorado has been conducted on a few well studied mountains. Aridity is one factor that has not been well studied but shows promise in explaining species richness. In Patagonia and the Swiss Alps, increasing aridity correlates with higher species richness. Here, a full species assessment was conducted on nine mountains previously under researched or …

Ms Environmental Biology Capstone Project, Taylor Readyhough

Regis University Student Publications (comprehensive collection)

Life in a zoo brings a score of stressors into the lives of captive animals, including artificial light, crowds of visitors, and increased noise levels. Stress especially impacts captive birds, and continued exposure to these stressors can negatively affect birds’ reproductive success and overall well-being. Staff at the Denver Zoo noticed increased aggression between a male and female pair of great Indian hornbills during the winter of 2016. This behavioral shift coincided with Zoo Lights, a holiday event that results in the hornbills’ exhibit remaining open to the public for approximately four extra hours through the entire month of December. …

Ms Environmental Biology Capstone Project, Elizabeth Sheehan

Regis University Student Publications (comprehensive collection)

Deforestation negatively impacts wildlife populations, specifically through the establishment of forest fragments – the breaking up of forest into small disconnected patches which increases the edge to interior ratio. Forest fragments are either created naturally or by anthropogenic causes. While both exhibit negative impacts on wildlife populations, anthropogenic edges may more negatively impact an animal population’s group size and sex ratio, which are vital to a population’s reproductive success and survival. The purpose of this research project is to gain insight into the effects of both natural and anthropogenic forest edges on white-faced capuchin’s (Cebus capucinus) group size and sex …

Ms Environmental Biology Capstone Project, Annamaria Marcel

Regis University Student Publications (comprehensive collection)

Due to the worldwide decline of biodiversity, protected nature reserves are necessary for species facing extinction. Many frog species have been experiencing rapid population decline and extinction due to the threat of the fungus Batrachochytrium dendrobatidis (Bd), which inflicts the highly transmittable and deadly disease chytridiomycosis. Chytridiomycosis causes increased skin tissue growth which disrupts respiration and the maintenance of water balance, which can ultimately lead to death. Certain ecological and geographical characteristics have been studied in order to assess their influence on Bd’s prevalence. Specifically, it is hypothesized that high elevations, lotic habitats, and low species richness have a positive …

The Association Between Type Of Fat And The Risk Of Developing Cardiovascular Diseases, Dovid Leib Glassner

The Science Journal of the Lander College of Arts and Sciences

Objective: To determine the significance of various types of dietary fat in the progression of atherosclerosis leading to heart disease. Methods: Study inclusion criteria constituted relevance to the discussion topic and peer reviewed literature. Age of the published material was taken into account as well, with greater preference being given to more recent research as the topic of nutrition and its relation to chronic disease remains an emerging science. Results: This research review found an overall significant relationship between the type (monounsaturated, polyunsaturated, saturated and trans-fat) of dietary fat intake and the incidence of cardiovascular disease. While earlier research identified …

Crimmigration In Gangland: Race, Crime, And Removal During The Prohibition Era, Geoffrey Heeren

Articles

In 1926, local law enforcement and federal immigration authorities in Chicago pursued a deportation drive ostensibly directed at gang members. However, the operation largely took the form of indiscriminate raids on immigrant neighborhoods of the city. Crimmigration in Gangland describes the largely forgotten 1926 deportation drive in Chicago as a means to augment the origin story for "crimmigration." Scholars up until now have mostly contended that the convergence of criminal and immigration law occurred in the 1980s as part of the War on Drugs, with crime serving as a proxy for race for policy makers unable to openly argue for …

Reconciliation Of Development And Ecosystems: The Ecology Of Governance In The International Columbia River Basin, Barbara Cosens

Articles

This article explores the emergence of formal and informal bridging organizations to facilitate solutions to water conflict at the scale of the water resource. This new approach to governance is of particular importance on rivers within or shared by countries in which water management is fragmented among national and sub-national levels of government as well as among governmental sectors. This article focuses on the Columbia River Basin, in the United States and Canada. Review of the Columbia River Treaty governing shared management of the river has opened a public dialogue on river governance. Treaty review coincides with change in both …

Lawrence University Course Catalog, 2018-2019, Lawrence University

Course Catalogs

No abstract provided.

Quantifying The Ability Of Common Invasive Shrubs To Acquire And Use Water, To Tolerate Drought, And Compete With Native Plants Within Holden Arboretum, Ohio, Sean Fenton, Brooke Sietz

Undergraduate Research Posters 2018

There is very little data on the interaction between native and invasive shrubs in Eastern North America. There are a number of traits that make the establishment and impact of shrubs different than other species. Early emergence of leaves and varying rates of photosynthesis play a significant role. How plants use water, and how plants are influenced by drought have not been studied thoroughly. This is important for a better understanding of how plants will respond to the alteration of precipitation regimes that occur from climate change. Research has been predominantly focused on how water availability can shape the interspecies …

General Undergraduate Catalog, 2018-2019, Marshall University

Marshall University Catalogs 2010-2019

Marshall University Undergraduate Course Catalog for the 2018-2019 academic year.

Graduate Catalog, 2018-2019, Marshall University

Marshall University Catalogs 2010-2019

Marshall University Graduate Course Catalog for the 2018-2019 academic year.

Et Cetera, Marshall University

Et Cetera

Founded in 1953, Et Cetera is an annual literary magazine that publishes the creative writing and artwork of Marshall University students and affiliates. Et Cetera is free to the Marshall University community.

Et Cetera welcomes submissions in literary and film criticism, poetry, short stories, drama, all types of creative non-fiction, photography, and art.

Connections, 01/2018, College Of Health And Human Services

College of Health and Human Services Newsletter

• CHHS dean search underway
• College gathering volunteers for Day of Caring
• College plans retention activities to increase enrollment
• Blind alum interviewed about voice recognition technology
• Art installation at CHHS brings attention to hidden pain
• Now enrolling: KG Bound Kids

The Graduate Standard - 01/2018, Western Michigan University

Graduate College news

• News from the Western Michigan University Graduate College
• WMU Alumna Accepts Faculty Position at University of Texas Tech Health Sciences Center
• Damon Chambers, immediate past president of Western Michigan University Graduate Student Association elected president of the National Association of Graduate-Professional Students
• Graduate Students in Geography Program Map a Promising Future

Osteopontin Deletion Drives Hematopoietic Stem Cell Mobilization To The Liver And Increases Hepatic Iron Contributing To Alcoholic Liver Disease., Fernando Magdaleno, Xiaodong Ge, Holger Fey, Yongke Lu, Harriet Gaskell, Chuck C. Blajszczak, Costica Aloman, M. Isabel Fiel, Natalia Nieto

Pharmacology, Physiology and Toxicology

The copy of record is available from the publisher at https://doi.org/10.1002/hep4.1116. Copyright © 2017 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Abstract: The aim of this study was to investigate the role of osteopontin (OPN) in hematopoietic stem cell (HPSC) mobilization to the liver …

Inspire E-News 01 2018, College Of Engineering And Applied Sciences

College of Engineering and Applied Sciences News

• Engineering management joins ranks of globally certified programs
• Graduate students awarded research and travel grants
• Save the Date Engineers Week Dinner
• New director of academic advising joins the college
• 58 undergraduates receive research awards
• Graduate students shine in 2017 Research and Creative Activities Poster Day
• Congratulations to Dr. Sam Ramrattan
• College Snapshot: 2016-17 Career Outcomes for Undergraduates

Mansfield Library Annual Report, 2016-2017, University Of Montana--Missoula. Mansfield Library

Mansfield Library Annual Reports

This Annual Report shares the efforts and activities of the Mansfield Library during the 2017 Fiscal Year. It highlights the ways in which the library furthered and supported the strategic goals outlined in Building the Future: The Mansfield Library Strategic Plan 2014-2017 and the University of Montana’s UM 2020: Building a University for the Global Century, including a snapshot of quantitative data and faculty scholarship.

Lagrangian Dispersion Characteristics In The Western Mediterranean, Maher Bouzaiene, Milena Menna, Pierre-Marie Poulain, Dalila Elhmaidi

Journal of Marine Research

Dispersion characteristics in the Western Mediterranean are analyzed using data from Coastal Ocean Dynamics Experiment (CODE) and Surface Velocity Program (SVP) surface drifters deployed in the period 1986–2017. Results are presented in terms of absolute dispersion A² (mean-squared displacement of drifter individuals) and of relative dispersion (D²; mean square separation distance of drifter pairs). Moreover, the dispersion characteristics are estimated for different initial separation distances (D₀) between particles: smaller, larger, or comparable with the internal Rossby radius of deformation. Results show the presence of a quasiballistic regime for absolute dispersion at small time scales and …

: Investigating The Influence Of Abiotic Variability On Escherichia Coli Population Dynamics In Three Denver, Co Springs, Tamara C. Burke

Regis University Student Publications (comprehensive collection)

Humans risk exposure to microbial pathogens when they use freshwater for recreation or as a drinking water source. In developing nations where monitoring and treatment of microbe-contaminated water is weak or unavailable, 1.8 million humans die each year from waterborne illnesses. In developed nations where public and private utilities treat drinking water, residents still remain vulnerable to these illnesses when they use recreational waters contaminated with sewage or animal feces. To assess whether streams and lakes should be closed to recreation, cities and counties closely monitor likely pathogen presence by testing for the indicator bacterium Escherichia coli (E. coli). …

Evidence Supporting Fda Approval And Cms National Coverage Determinations For Novel Medical Products, 2005 Through 2016: A Cross-Sectional Study, Aliya Cecilia Roginiel

Yale Medicine Thesis Digital Library

EVIDENCE SUPPORTING FDA APPROVAL AND CMS NATIONAL COVERAGE DETERMINATIONS FOR NOVEL MEDICAL PRODUCTS, 2005 THROUGH 2016: A CROSS-SECTIONAL STUDY

Aliya C. Roginiel, Sanket S. Dhruva, Joseph S. Ross

Department of Internal Medicine, Yale University School of Medicine, New Haven, CT

Abstract:

Food and Drug Administration (FDA) and Centers for Medicare and Medicaid Services (CMS) rely on evidence from clinical trials when approving a therapeutic for marketing and insurance coverage in the US, respectively. No study has compared the quality and quantity of evidence examined by these agencies. Our purpose was to characterize evidence used by FDA and CMS to support …

Alterations In Wheat Pollen Lipidome During High Day And Night Temperature Stress, Sruthi Narayanan, P.V. Vara Prasad, Ruth Welti

Publications

Understanding the adaptive changes in wheat pollen lipidome under high temperature (HT) stress is critical to improving seed set and developing HT tolerant wheat varieties. We measured 89 pollen lipid species under optimum and high day and/or night temperatures using electrospray ionization-tandem mass spectrometry in wheat plants. The pollen lipidome had a distinct composition compared to that of leaves. Unlike in leaves, 34:3 and 36:6 species dominated the composition of extraplastidic phospholipids in pollen under optimum and HT conditions. The most HT-responsive lipids were extraplastidic phospholipids, PC, PE, PI, PA, and PS. The unsaturation levels of the extraplastidic phospholipids decreased …

A New Model Of Wheezing Severity In Young Children Using The Validated Isaac Wheezing Module: A Latent Variable Approach With Validation In Independent Cohorts., Steven M. Brunwasser Phd, Tebeb Gebretsadik, Diane R Gold, Kedir N Turi, Cosby A Stone, Soma Datta, James E Gern, Tina V Hartert

College of Science & Mathematics Departmental Research

BACKGROUND: The International Study of Asthma and Allergies in Children (ISAAC) Wheezing Module is commonly used to characterize pediatric asthma in epidemiological studies, including nearly all airway cohorts participating in the Environmental Influences on Child Health Outcomes (ECHO) consortium. However, there is no consensus model for operationalizing wheezing severity with this instrument in explanatory research studies. Severity is typically measured using coarsely-defined categorical variables, reducing power and potentially underestimating etiological associations. More precise measurement approaches could improve testing of etiological theories of wheezing illness.

METHODS: We evaluated a continuous latent variable model of pediatric wheezing severity based on four ISAAC …

Ua19/16/1 Women's Basketball Media Guide, Wku Athletic Media Relations

WKU Administration Documents

2018-19 women's basketball media guide produced by WKU Athletic Media Relations, includes athletic records and statistics, photographs, schedule and information regarding opponents.