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2018

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Amphibians Among Road-Rut Pools In West Virginia, Abby L. Sinclair Jan 2018

Amphibians Among Road-Rut Pools In West Virginia, Abby L. Sinclair

Theses, Dissertations and Capstones

As anthropogenic environmental stressors such as urbanization continue to increase, it is necessary to understand their impact on amphibian ecology. Due largely to their biphasic life history amphibians are negatively impacted by the destruction of lotic habitats i.e., wetlands for the creation of roads and urban centers. I examined the effects of three human-made road rut pools on the reproductive success and species richness of amphibians in southwest West Virginia from May to October 2012. I employed three detection techniques: drift fence pitfall trap arrays, funnel traps and dipnet sampling. Additionally, habitat covariates were taken (i.e., water depth) at each …


Influence Of Developmental Stage, Habitat, And Captivity On Thecutaneous Bacterial Communities Of Eastern Hellbenders (Cryptobranchus Alleganiensis Alleganiensis) In West Virginia, Rachel Fern Arrick Jan 2018

Influence Of Developmental Stage, Habitat, And Captivity On Thecutaneous Bacterial Communities Of Eastern Hellbenders (Cryptobranchus Alleganiensis Alleganiensis) In West Virginia, Rachel Fern Arrick

Theses, Dissertations and Capstones

Microbes inhabit virtually all surfaces of multicellular animal hosts, with microbial cells outnumbering the hosts’ own cells 10:1. Symbiont microbes, collectively referred to as the microbiome, can have profound impacts on the metabolism, development, behavior, and disease resistance of their multicellular hosts. Because the community structure of symbiont bacteria can influence host health, the characterization of amphibian microbiomes is becoming an increasingly important tool for future conservation in the face of global amphibian declines. Eastern hellbenders are good candidates for a microbiome study because they have seen substantial declines in recent decades and learning more about the environmental and physiological …


Harm Reduction Programs: West Virginia Vs. United States, Morgan L. Belcher, Hannah Sayre Jan 2018

Harm Reduction Programs: West Virginia Vs. United States, Morgan L. Belcher, Hannah Sayre

Theses, Dissertations and Capstones

Introduction: Harm reduction has been a movement for social justice built on a belief in, and respect for, the rights of people who use drugs. It has been defined as a set of practical strategies and ideas aimed at reducing negative consequences associated with drug use. The U.S. has been experiencing an opioid/heroin epidemic, with significant increases in overdose death among drug users with more than 72,000 Americans having died from drug overdoses in 2017.

Methodology: The methodology for this study was a literature review with a semi structured interview with Tina Rameriz of the Kanawha-Charleston Health Department …


Using Existing Bibliographic Resources To Compile Faculty Publication Lists: A Case Study From San José State University, Ngoc-Yen Tran, Emily K. Chan Jan 2018

Using Existing Bibliographic Resources To Compile Faculty Publication Lists: A Case Study From San José State University, Ngoc-Yen Tran, Emily K. Chan

Faculty and Staff Publications

With limited campus resources for faculty scholarship, the College of Science (CoS) at San José State University (SJSU) developed scholarly output metrics as a way to add a quantitative component to the distribution of funds, to ensure objectivity, and to reward proven researchers. To support CoS's efforts to identify and quantify science faculty research publications, we compiled a bibliography of science faculty research and scholarship which would be used to develop and formalize baseline research metrics. Using existing and available resources including librarian time, subscribed science databases, and the institution-subscribed reference citation manager, we developed a method by which any …


In All Fairness: Two Decades Of Cedaw And The State Of Gender Equality In Singapore, Ning Qian Jan 2018

In All Fairness: Two Decades Of Cedaw And The State Of Gender Equality In Singapore, Ning Qian

Social Space

In an inclusive society, all women would have equal opportunities as men to participate socially, politically and economically. They would be valued and recognised as individuals in their own right and not primarily defi ned by their marital and reproductive status. Has this been achieved in Singapore? Contrary to common belief, the nation still has some ways to go in this regard, for signifi cant groups of women in Singapore continue to be marginalised and disadvantaged.


How To Refine The Frbr Hierarchy: A Case Study Of Expressions Of Works By Children's Author Eileen Christelow, Frank Newton Jan 2018

How To Refine The Frbr Hierarchy: A Case Study Of Expressions Of Works By Children's Author Eileen Christelow, Frank Newton

Dover Library Faculty Professional Development Activities

It is proposed that the proper procedure for positing hierarchical levels between Work and Manifestation (Edition), in the FRBR (or WEMI) hierarchy, is to make a study of all the editions of selected works as recorded in OCLC WorldCat, and to determine inductively the most useful hierarchical levels between the top level of the Work and the lower and traditional level of the Manifestation or Edition. WorldCat was searched for all works by children's author Eileen Christelow. The 652 bib records were assigned to works, subclassified by key properties. Two intermediate levels popped out from this analysis: language and format.


Post Title Ix Representations Of Professional Female Athletes, Emily Shaw Jan 2018

Post Title Ix Representations Of Professional Female Athletes, Emily Shaw

MA in English Theses

Since the enactment of Title IX in 1972, female participation in athletics grows every year. Interestingly, media representations of professional female athletes have not always been indicative of this exciting and growing participation. This study explores the representations of professional female athletes and discusses implications and affordances of magazine and social media. In particular, the research analyzes five Sports Illustrated magazine covers and thirty Instagram posts to explore how female athletes have been presented on magazine covers and how they are representing themselves on social media. Using theories of gender, media, self-presentation, and visual rhetoric, this thesis analyzes how Sports …


Exploring The Impact Of Feedback On Learning Transfer In The Liminal Space For Information Literacy, Natalie Edwards Bishop Jan 2018

Exploring The Impact Of Feedback On Learning Transfer In The Liminal Space For Information Literacy, Natalie Edwards Bishop

Education Dissertations and Projects

Mastering new knowledge is a transformative process, but what happens between initial confrontation with new knowledge and the moment it is mastered? This qualitative case study investigated perceptions on how feedback loops influenced student growth and learning transfer in the liminal space. Myer and Land (2005) described the liminal space as a stuck place where learners are wrestling with their conceptual understanding of knowledge that is troublesome.

Students were adult undergraduates in an online information literacy course. Librarians teaching the course were early adopters of ACRL’s The Framework for Information Literacy in Higher Education (the Framework) and participated in on-site …


Filling The Reading Void: Studying Reading Stamina In A Suburban High School Through Action Research: A Companion Research Study, Lindsey Weycker Jan 2018

Filling The Reading Void: Studying Reading Stamina In A Suburban High School Through Action Research: A Companion Research Study, Lindsey Weycker

Education Dissertations and Projects

A common practice in elementary schools is to allow students silent reading time during school. Experts agree this is best practice due to the benefits to students, especially in vocabulary development and reading stamina. As students age, however, this practice tends to decline in favor of activities that are meant to teach vocabulary in isolation and test preparation skills. In addition to these activities, English language arts classes typically read and study novels together as a class for the purpose of studying literary devices and literary analysis. Because of these practices, secondary students tend to read less, which in turn …


Exploring Patterns Of Health-Promoting Lifestyles Of Academic Nurse Educators, Tracy Campbell Jan 2018

Exploring Patterns Of Health-Promoting Lifestyles Of Academic Nurse Educators, Tracy Campbell

Nursing Theses and Capstone Projects

Participating in health-promoting behaviors is essential for maintaining optimal physical and mental well-being. Nurses play a significant role in supporting the nation’s health, however, nursing shortages impact the ability to meet the complex health demands in a growing population. Guided by Nola J. Pender's health promotion model, the purpose of this study was to evaluate the self-perceived health-promoting lifestyle behaviors of faculty nurse educators. A convenience sample of 13 faculty nurses were studied using a descriptive, non-experimental research design. The 52-item Health-Promoting Lifestyle II (HPLP II) survey was used to evaluate the six dimensions of: health responsibility, interpersonal relations, nutrition, …


Glass Beads In Iron-Age And Early-Modern Taiwan: An Introduction, Kuan-Wen Wang Jan 2018

Glass Beads In Iron-Age And Early-Modern Taiwan: An Introduction, Kuan-Wen Wang

BEADS: Journal of the Society of Bead Researchers

Archaeological research has revealed a long history of glass bead exchange and use in Taiwan, yet it has seldom been discussed in the literature. This paper provides an introduction to this exchange from the Iron Age (ca. late 1st millennium BC – mid-2nd millennium AD) to the early modern period (ca. AD 1600-1900) by revisiting the archaeological and historical records. It is suggested that changes in bead styles and chemical compositions over time reveal the transition of bead supply in Taiwan, which further reflects two broad phases of bead trade: Phase I) the earlier involvement of Taiwan in the Indo-Pacific …


Stone Beads In Oman During The 3rd To 2nd Millenia Bce: New Approaches To The Study Of Trade And Technology, Jonathan Mark Kenoyer, Dennys Frenez Jan 2018

Stone Beads In Oman During The 3rd To 2nd Millenia Bce: New Approaches To The Study Of Trade And Technology, Jonathan Mark Kenoyer, Dennys Frenez

BEADS: Journal of the Society of Bead Researchers

This paper focuses primarily on ancient stone beads found in Oman at sites dating to the 3rd to 2nd millennium BCE, generally dated to the Umm an-Nar and Wadi Suq periods. Archaeological collections were documented to determine the range of variation in the finished objects and if there is evidence for local production of carnelian and other hard-stone beads. A comparative analysis with published materials from other regions was also undertaken to document the bead types in Oman that might have been obtained through trade networks that linked this region to Mesopotamia, Iran, the Indus Valley region, Afghanistan, Egypt, and …


University Of Richmond Sustainability Plan 2019-2025, University Of Richmond Jan 2018

University Of Richmond Sustainability Plan 2019-2025, University Of Richmond

Plans

University of Richmond’s Sustainability Plan is a blueprint for how we as a campus community will achieve a long-term vision of integrating sustainability into the fabric of the University. The result of a yearlong collaborative effort involving hundreds of stakeholders, the plan lays out clear steps to bolster the development of sustainability in the curriculum, support environmental management of our campus, promote a culture of sustainability, and further integrate stewardship into administrative policies and procedures. The time frame for the goals, strategies, and actions articulated in this plan is 2019-2025.


Book Review, Anton Weiss-Wendt, The Soviet Union And The Gutting Of The Un Genocide Convention (2017), Mark A. Drumbl Jan 2018

Book Review, Anton Weiss-Wendt, The Soviet Union And The Gutting Of The Un Genocide Convention (2017), Mark A. Drumbl

Scholarly Articles

Weiss-Wendt’s book unpacks what happened to “genocide” as it journeyed along this path of codification. To be clear, codification was conditioned by compromise among states; and states were often motivated by Cold War selfishness, spite, manipulation, and machination. The Convention narrowed—and even mangled—the set of protected groups to national, ethnic, racial, and religious. The Convention, moreover, limited the recognized forms that genocide could take. The title of Weiss-Wendt’s book reflects its argument that the expansiveness of genocide as an idea was “gutted” in the process of codifying it in an international treaty.


Catalpa, University Of Tennessee At Chattanooga Jan 2018

Catalpa, University Of Tennessee At Chattanooga

Catalpa

No abstract provided.


Western Michigan University Graduate Catalog 2018-2019, Western Michigan University Jan 2018

Western Michigan University Graduate Catalog 2018-2019, Western Michigan University

Western Michigan University Course Catalogs (1904-present)

  • General Information
  • Calendars
  • Western Michigan University Strategic Plan
  • Graduate College


Crosstalk Among Lncrnas, Micrornas And Mrnas In The Muscle ‘Degradome’ Of Rainbow Trout, Bam Paneru, Ali Ali, Rafet Al-Tobasei, Brett Kenney, Mohamed Salem Jan 2018

Crosstalk Among Lncrnas, Micrornas And Mrnas In The Muscle ‘Degradome’ Of Rainbow Trout, Bam Paneru, Ali Ali, Rafet Al-Tobasei, Brett Kenney, Mohamed Salem

Faculty & Staff Scholarship

In fish, protein-coding and noncoding genes involved in muscle atrophy are not fully characterized. In this study, we characterized coding and noncoding genes involved in gonadogenesis-associated muscle atrophy, and investigated the potential functional interplay between these genes. Using RNA- Seq, we compared expression pattern of mRNAs, long noncoding RNAs (lncRNAs) and microRNAs of atrophying skeletal muscle from gravid females and control skeletal muscle from age-matched sterile individuals. A total of 852 mRNAs, 1,160 lncRNAs and 28 microRNAs were differentially expressed (DE) between the two groups. Muscle atrophy appears to be mediated by many genes encoding ubiquitin- proteasome system, autophagy related …


Center For Grassland Studies, Volume 24, Issue 4, Winter 2018 Jan 2018

Center For Grassland Studies, Volume 24, Issue 4, Winter 2018

Center for Grassland Studies: Newsletters

Nebraska’s Prairie Heritage is an IANR Priority

Director's Comments

Alumni Spotlight: Kristin (Nollette) Schlueter

PGA Golf Management Students Compete in 2018 Jones Cup

Ron Hanson Receives Silver Eagle Award

Leu Lecturer: Dr. Chuck West

PGA Elects Female President

Crop Residue Exchange Connects Cattle Producer with Available Forage

Nebraska Grazing Lands Coalition Hosts Jason Rowntree

Internship Experiences Highlighted

GLS Alumnus Shares Ranch Management Practices


Building Resilience Among Orphaned And Vulnerable Children Through The Memory Book Intervention, Barbara J. Braband, Tamara Faris, Kaye Wilson-Anderson Jan 2018

Building Resilience Among Orphaned And Vulnerable Children Through The Memory Book Intervention, Barbara J. Braband, Tamara Faris, Kaye Wilson-Anderson

Faculty Publications - College of Nursing

Children who are orphaned and vulnerable due to poverty, war, or disease (HIV/AIDS) may experience childhood traumatic grief. A qualitative phenomenological approach was implemented to explore and compare the lived experiences of orphaned children, adolescents, and caregivers who had used the Memory Book intervention at six children’s homes in India, Kenya, and South Africa. Study findings revealed similar themes between the countries, with primary themes of identity and relationships, and secondary themes of coping, hope, and emotion. Findings suggest the value of Memory Book resources to encourage the preservation of a child’s story and grief recovery that can be used …


Reduction Of Endothelial Nitric Oxide Increases The Adhesiveness Of Constitutive Endothelial Membrane Icam-1 Through Src-Mediated Phosphorylation, Feng Gao, Brandon P. Lucke-Wold, Xiang Li, Aric F. Logsdon, Li-Chong Xu, Sulei Xu, Kyle B. Lapenna, Huaqi Wang, M.A. Hassan Talukder, Christopher A. Siedlecki, Jason D. Huber, Charles L. Rosen, Pingnian He Jan 2018

Reduction Of Endothelial Nitric Oxide Increases The Adhesiveness Of Constitutive Endothelial Membrane Icam-1 Through Src-Mediated Phosphorylation, Feng Gao, Brandon P. Lucke-Wold, Xiang Li, Aric F. Logsdon, Li-Chong Xu, Sulei Xu, Kyle B. Lapenna, Huaqi Wang, M.A. Hassan Talukder, Christopher A. Siedlecki, Jason D. Huber, Charles L. Rosen, Pingnian He

Faculty & Staff Scholarship

Nitric oxide (NO) is a known anti-adhesive molecule that prevents platelet aggregation and leukocyte adhesion to endothelial cells (ECs). The mechanism has been attributed to its role in the regulation of adhesion molecules on leukocytes and the adhesive properties of platelets. Our previous study conducted in rat venules found that reduction of EC basal NO synthesis caused EC ICAM-1-mediated firm adhesion of leukocytes within 10–30min. This quick response occurred in the absence of alterations of adhesion molecules on leukocytes and also opposes the classical pattern of ICAM-1-mediated leukocyte adhesion that requires protein synthesis and occurs hours after stimulation. The objective …


Bordetella Pertussis Whole Cell Immunization, Unlike Acellular Immunization, Mimics Naïve Infection By Driving Hematopoietic Stem And Progenitor Cell Expansion In Mice, Melinda E. Varney, Dylan T. Boehm, Katherine Deroos, Evan S. Nowak, Ting Y. Wong, Emel Sen-Kilic, Shebly D. Bradford, Cody Elkins, Matthew S. Epperly, William T. Witt, Mariette Barbier, F. Heath Damron Jan 2018

Bordetella Pertussis Whole Cell Immunization, Unlike Acellular Immunization, Mimics Naïve Infection By Driving Hematopoietic Stem And Progenitor Cell Expansion In Mice, Melinda E. Varney, Dylan T. Boehm, Katherine Deroos, Evan S. Nowak, Ting Y. Wong, Emel Sen-Kilic, Shebly D. Bradford, Cody Elkins, Matthew S. Epperly, William T. Witt, Mariette Barbier, F. Heath Damron

Faculty & Staff Scholarship

Hematopoietic stem and progenitor cell (HSPC) compartments are altered to direct immune responses to infection. Their roles during immunization are not well-described. To elucidate mechanisms for waning immunity following immunization with acellular vaccines (ACVs) against Bordetella pertussis (Bp), we tested the hypothesis that immunization with Bp ACVs and whole cell vaccines (WCVs) differ in directing the HSPC characteristics and immune cell development patterns that ultimately contribute to the types and quantities of cells produced to fight infection. Our data demonstrate that compared to control and ACV-immunized CD-1 mice, immunization with an efficacious WCV drives expansion of hematopoietic multipotent progenitor cells …


Direct Observation Of The Effects Of Cellulose Synthesis Inhibitors Using Live Cell Imaging Of Cellulose Synthase (Cesa) In Physcomitrella Patens, Mai L. Tran, Thomas W. Mccarthy, Hao Sun, Shu-Zon Wu, Joanna H. Norris, Magdalena Bezanilla, Luis Vidali, Charles T. Anderson, Alison W. Roberts Jan 2018

Direct Observation Of The Effects Of Cellulose Synthesis Inhibitors Using Live Cell Imaging Of Cellulose Synthase (Cesa) In Physcomitrella Patens, Mai L. Tran, Thomas W. Mccarthy, Hao Sun, Shu-Zon Wu, Joanna H. Norris, Magdalena Bezanilla, Luis Vidali, Charles T. Anderson, Alison W. Roberts

Biological Sciences Faculty Publications

Results from live cell imaging of fluorescently tagged Cellulose Synthase (CESA) proteins in Cellulose Synthesis Complexes (CSCs) have enhanced our understanding of cellulose biosynthesis, including the mechanisms of action of cellulose synthesis inhibitors. However, this method has been applied only in Arabidopsis thaliana and Brachypodium distachyon thus far. Results from freeze fracture electron microscopy of protonemal filaments of the moss Funaria hygrometrica indicate that a cellulose synthesis inhibitor, 2,6-dichlorobenzonitrile (DCB), fragments CSCs and clears them from the plasma membrane. This differs from Arabidopsis, in which DCB causes CSC accumulation in the plasma membrane and a different cellulose synthesis inhibitor, isoxaben, …


Spatial Ecology Of Carcharias Taurus In The Northwestern Mid-Atlantic Coastal Ocean, D. E. Haulsee, M. W. Breece, L. M. Brown, Bradley M. Wetherbee, D. A. Fox, M. J. Oliver Jan 2018

Spatial Ecology Of Carcharias Taurus In The Northwestern Mid-Atlantic Coastal Ocean, D. E. Haulsee, M. W. Breece, L. M. Brown, Bradley M. Wetherbee, D. A. Fox, M. J. Oliver

Biological Sciences Faculty Publications

The sand tiger shark Carcharias taurus is a highly migratory coastal species with declining populations worldwide. This species exhibits many behaviors that make coastal sharks difficult to manage, including aggregatory behavior, sexual segregation, and large-scale migrations through shallow coastal waters with many opportunities for human interactions. Sand tigers from the Western North Atlantic subpopulation are known to seasonally inhabit Delaware Bay and surrounding coastal waters. This region has been recommended as a habitat area of particular concern for the Western North Atlantic sand tiger population, and increased understanding of their movements and habitat requirements will facilitate management efforts. We developed …


Can Darapsa Myron (Lepidoptera: Sphingidae) Successfully Use The Invasive Plant Ampelopsis Brevipedunculata As A Food Resource?, Alex K. Baranowski, Evan L. Preisser Jan 2018

Can Darapsa Myron (Lepidoptera: Sphingidae) Successfully Use The Invasive Plant Ampelopsis Brevipedunculata As A Food Resource?, Alex K. Baranowski, Evan L. Preisser

Biological Sciences Faculty Publications

Although biological invasions are generally thought to negatively impact native fauna, native herbivores that can utilize invasive plants may benefit. The East Coast of the United States has been invaded by the vitaceous plant Ampelopsis brevipedunculata. The invaded range of A. brevipedunculata overlaps with that of the native Vitis labrusca, a closely-related species that is a host plant for the native moth Darapsa myron (Lepidoptera: Sphingidae). We reared D. myron larvae on either V. labrusca or A. brevipedunculata to assess whether development and survival differed on the two plant species. Larval growth and survival to pupation was only …


Why Do Girls Outperform Boys In School: A Qualitative Study Of Boy-Friendly Teaching, Teacher Efficacy And Practices, Renee Blair Clifford Jan 2018

Why Do Girls Outperform Boys In School: A Qualitative Study Of Boy-Friendly Teaching, Teacher Efficacy And Practices, Renee Blair Clifford

Education Dissertations and Projects

This research study explored reasons why girls consistently outperform boys in the classroom, examining professional development teachers may have received, strategies teachers are implementing, and teacher’s self-efficacy in teaching boys. This was a qualitative study centered on the idea that boys do not perform as well in school as girls because teachers are not aware of learning differences or not designing instruction to address the unique learning needs of boys. This study took place at one South East elementary school.


The Role Of Tgf-Β/Smad4 Signaling In Cancer, M Zhao, Lopa Mishra, C Deng Jan 2018

The Role Of Tgf-Β/Smad4 Signaling In Cancer, M Zhao, Lopa Mishra, C Deng

Surgery Faculty Publications

Transforming growth factor β (TGF-β) signaling pathway plays important roles in many biological processes, including cell growth, differentiation, apoptosis, migration, as well as cancer initiation and progression. SMAD4, which serves as the central mediator of TGF-β signaling, is specifically inactivated in over half of pancreatic duct adenocarcinoma, and varying degrees in many other types of cancers. In the past two decades, multiple studies have revealed that SMAD4 loss on its own does not initiate tumor formation, but can promote tumor progression initiated by other genes, such as KRAS activation in pancreatic duct adenocarcinoma and APC inactivation in colorectal cancer. In …


The Tragedy Of Lutheran Jurisprudence, Augusto Zimmermann Jan 2018

The Tragedy Of Lutheran Jurisprudence, Augusto Zimmermann

The University of Notre Dame Australia Law Review

The teachings of Martin Luther (1483–1546) launched the Protestant Reformation in the 16th century. Luther believed in a discontinuity between God and humans that makes it impossible to provide an account of morality by reference to natural law. Rather, Lutheran jurisprudence rejects natural-law theory and it largely remains in the shadows of narrow legal positivism. According to Lutheran jurisprudence, lawfully promulgated decrees are laws even if they are completely arbitrary in their purpose and effect. Luther derived his doctrine on civil government exclusively from Chapter 13 of St Paul’s Epistle to the Romans. He saw in this passage no legitimate …


Optimization Of Wavelength Selection For Multispectral Image Acquisition: A Case Study Of Atrial Ablation Lesions, Huda Asfour, S. Guan, Narine Muselimyan, Luther M. Swift, Murray Loew, Narine Sarvazyan Jan 2018

Optimization Of Wavelength Selection For Multispectral Image Acquisition: A Case Study Of Atrial Ablation Lesions, Huda Asfour, S. Guan, Narine Muselimyan, Luther M. Swift, Murray Loew, Narine Sarvazyan

Pharmacology and Physiology Faculty Publications

In vivo autofluorescence hyperspectral imaging of moving objects can be challenging due to motion artifacts and to the limited amount of acquired photons. To address both limitations, we selectively reduced the number of spectral bands while maintaining accurate target identification. Several downsampling approaches were applied to data obtained from the atrial tissue of adult pigs with sites of radiofrequency ablation lesions. Standard image qualifiers such as the mean square error, the peak signal-to-noise ratio, the structural similarity index map, and an accuracy index of lesion component images were used to quantify the effects of spectral binning, an increased spectral distance …


Granulin Secreted By The Food-Borne Liver Fluke, Brandon Haugen, Shannon E Karinshak, Victoria H Mann, Anastas Popratiloff, Alex Loukas, Paul J Brindley, Michael J Smout Jan 2018

Granulin Secreted By The Food-Borne Liver Fluke, Brandon Haugen, Shannon E Karinshak, Victoria H Mann, Anastas Popratiloff, Alex Loukas, Paul J Brindley, Michael J Smout

Microbiology, Immunology, and Tropical Medicine Faculty Publications

The liver fluke Opisthorchis viverrini is a food-borne, zoonotic pathogen endemic to Thailand and adjacent countries in Southeast Asia. The adult developmental stage of the O. viverrini parasite excretes and secretes numerous proteins within the biliary tract including the gall bladder. Lesions caused by the feeding activities of the liver fluke represent wounds that undergo protracted cycles of healing and re-injury during chronic infection, which can last for decades. Components of the excretory/secretory (ES) complement released by the worms capably drive proliferation of bile duct epithelial cells and are implicated in establishing the oncogenic milieu that leads to bile duct …


Granulin Secreted By The Food-Borne Liver Fluke Opisthorchis Viverrini Promotes Angiogenesis In Human Endothelial Cells, Brandon Haugen, Shannon Karinshak, Victoria H. Mann, Anastas Popratiloff, Alex Loukas, Paul J. Brindley, Michael J. Smout Jan 2018

Granulin Secreted By The Food-Borne Liver Fluke Opisthorchis Viverrini Promotes Angiogenesis In Human Endothelial Cells, Brandon Haugen, Shannon Karinshak, Victoria H. Mann, Anastas Popratiloff, Alex Loukas, Paul J. Brindley, Michael J. Smout

Microbiology, Immunology, and Tropical Medicine Faculty Publications

The liver fluke Opisthorchis viverrini is a food-borne, zoonotic pathogen endemic to Thailand and adjacent countries in Southeast Asia. The adult developmental stage of the O. viverrini parasite excretes and secretes numerous proteins within the biliary tract including the gall bladder. Lesions caused by the feeding activities of the liver fluke represent wounds that undergo protracted cycles of healing and re-injury during chronic infection, which can last for decades. Components of the excretory/secretory (ES) complement released by the worms capably drive proliferation of bile duct epithelial cells and are implicated in establishing the oncogenic milieu that leads to bile duct …