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The Forum: Journal of History

No abstract provided.

Using Of Water-Heating Convective Drying Unit Dehydration Medicinal Plants, Sh.A Sultanova, J.E Safarov, U.M Azizov

Problems and Perspectives in Pharmaceutics and Drug Discovery

The technique and technology of drying medicinal plants with preservation of biologically active sub-stancesis developed. The characteristics of the processes of sorption and desorption of medicinal plants are studied. Based on the results of the study of the thermal and sorption properties of the dried products, the permissible temperature, drying time and the principle of the installation of a water-heating convec-tion dryer have been determined. The composition of the final product is determined.

Biologically Active Compounds From Alhagi Canescens, S.Z Nishanbaev, Kh.M Bobakulov, S.A Sasmakov

Problems and Perspectives in Pharmaceutics and Drug Discovery

By column chromatography and rechromatography from the aerial part of Alhagi canescens, grow-ing in Uzbekistan isolated one cyclic alcohol and three flavonoid nature substances. The structures of the isolated compounds were established by chromatographic, spectral methods (IR-, UV-, and NMR-spectra) and by comparison with authentically known samples. These compounds from the aerial part of Alhagi canescens are isolated for the first time.

Topaz, Nurell-D Pesticides In The Real Events, M. I Nurmatova, M. N Nurmatova, D.A Zulfikarieva

Problems and Perspectives in Pharmaceutics and Drug Discovery

Investigation of topaz, nurell-d in physical evidence.In the practice of forensic chemistry, pesticides have been found. Thin layer chromatography from internal organs of physical evidence was carried out. The results were compared with standard solutions of topazandnurell-d. The technique of detection of to-paz pesticide was studied by methods of thermodisorption surface ionization spectroscopy. The possibility of using this method in the analysis of topaz, nurell-d isolated from biological objects is shown.

Biological Activity Compounds Of Lepidolopha Komarovii Areal Part, R.Kh. Abdullaeva,, Kh .M Bobakulov, S.Z Nishanbayev,

Problems and Perspectives in Pharmaceutics and Drug Discovery

Phenolcarbonic acid and three flavonoid substances isolated from the aerial part of Lepidolopha kom-arovii, growing in Uzbekistan by column chromatography and rechromatography. The isolated compounds were identified by spectral (UV, IR, 1H and 13C NMR spectra), chromatographic methods and comparison with true samples. These compounds of aerial part of the plant Lepidolopha komarovii are isolated for the first time.

Standardization Of The Herb Phlomis Thapsoides (Bge), Which Grows In Uzbekistan., M.T Mullajonova,, G.K. Orifjonova, A.К. Ganiev

Problems and Perspectives in Pharmaceutics and Drug Discovery

he work provides the result of researches on an establishment of reliable characteristics of authentic-ity, good quality of local raw materials jerusalim sage and the necessity of its standardizations with the purpose of advancement in medical practice.Key words:herba Phlomis thapsoides, flavonoids, humidity, the organic impurity that is insoluble in 10% solution of hydrochloric acid, mineral,impurity, microbiological purity.

Pharmacological Screening Of Diuretic Tea, N.T. Farmanova, F.F. .Urmаnоvа, А.I. Khudoyberdiev

Problems and Perspectives in Pharmaceutics and Drug Discovery

There have been developed the optimal composition of diuretic species“Stiflos” made of medicinal herbs, supplied with sufficient raw material base in the territory of the Republic.As a result of the combined experimental and clinical studies, it was recommended as an effective diuretic for cardiovascular system diseases associated with kidney, liver, urinary tract and circulatory failure.

Analysis Of Mineral Composition Extract Of Ferula Aseefoetida L. Rhizomes And Extract Of Curcuma Longa L. Rhizomes, Sh.F Iskandarova, N.S Abdukhalilova

Problems and Perspectives in Pharmaceutics and Drug Discovery

It has been conducted the analysis of macro- and micro elemental composition of dry extract obtained from ferula asee-foetida rhizomes and dry extract obtained from curcuma longa rhizomes. It has been revealed that samples have the balanced macro– and micro elemental composition. According to the results of conducted research the obtained products are recommended for developing the capsuled biologically active supplements for food.

Determination Of The Degree Of Hygroscopicity Of The Substance Of Biologically Active Additive "Ravonol", B.T. Sagdullaev,, Sh.M Turaboev,, F.N Atamuratov,

Problems and Perspectives in Pharmaceutics and Drug Discovery

The substance of the biologically active additive "Ravonol" from the fruits of Prunus domestica L. was obtained. The obtained substance was investigated by light microscopy and it was established that the substance consists of irregular, different size, randomly anisometric particles. The method of light mi-croscopy was conducted according to the State Pharmacopoeia of the Russian Federation. The degree of hygroscopicity of the substance is determined by the European Pharmacopoeia.

Technology And Biopharmacy Of Gel Intended For The Treatment Of Periodontal Diseases, N.М Rizayeva, N.М Vakhidova, N.S Fayzullaeva

Problems and Perspectives in Pharmaceutics and Drug Discovery

As a result of the conducted studies, it was found that the amount of diffused tannins in the 2% agar-agar gel from the dental gel of medicinal sage prepared on the basis of Na-KMC is 10-15% greater than that of the gel prepared on the basis of MC. It was also noted that samples of the dental gel based on Na-CMC, diffused in a 5% gelatin gel, are 25-30% larger than those from the MC-based gel. From this it can be concluded that in the studies of the bioavailability of hydrogels in "in vitro" experiments by the method of direct …

Effect Of Hypoglycemic Collection On Intensity Of Glucone-Ogenesis In Tissue Of Liver In Norm And At Experimental Diabetes, G.Yu Malikova, A.A Juraeva, N.U Karimova

Problems and Perspectives in Pharmaceutics and Drug Discovery

Тhe results of studying the hypoglycemic properties of plant collection are carried out. The main links of glucose metabolism in the liver and muscles under conditions of experimental diabetes under the influ-ence of collection were compared with the simultaneous comparison with the effect of insulin on these processes. The effect of collecting on the rate of glucose formation from its precursors under conditions of hyperglycemia of alloxan origin in the liver was studied.

Development Of Technology For Obtaining Immunostimulating Extracts Based On Medicinal Plants, M.A Akbaraliev, M.G Ismailova, T.F Ibragimov

Problems and Perspectives in Pharmaceutics and Drug Discovery

In these scientific studies, dry extracts of Echinacea purpurea (Echinacea purpurea (L.) Moench), measles of birch (Betula pendula) and rhodiola rosea (Rhodiola rosea) were obtained. Extraction condi-tions, the nature of the extragents, the grinding factor of the raw materials, various methods for obtaining extracts were studied. The quantitative content of active substances in dry extract was analyzed depending on the conditions of production.

Influence Of "Glucohol" On Biochemical Indicators Of Blood In Rats, N.S. Aripdjanova, X.M. Kamilov, Z.T. .Fayziyeva

Problems and Perspectives in Pharmaceutics and Drug Discovery

The biological activity of a mixture of dry extracts of Тribulus terrestris and Кareleniya Caspian in various proportions in acute hyperglycemia was revealed that in the concentration of 5 and 15 of the ex- tract of the mixture, it gains high hypoglycemic activity and the dry extract is not inferior in activity to the preparation Glucare.

He Studying Of Influence New Antineoplastic Preparation К-26 On Synthesis Dna/Rna And Expression Of Genes Mdr2 Drug Resistance And P53 Tumor Suppressor, A.A Ibragimov, Z.M Enikeeva, M.N Tilljashajhov

Problems and Perspectives in Pharmaceutics and Drug Discovery

By experiments on studying of influence of preparation К-26 on synthesis DNA and RNA, an expres-sion of MDR2 drug resistance gene and p53 gene it is established, that in tumor cells the preparation sup-presses synthesis DNA and RNA than etoposide. Low level of an expression MDR2 gene (within 15 %) in comparison with for the most expression of this gene under influence etoposide is observed. The gene ex-pression р53 considerably increases to 80 % (at etoposide to 55 %), that defines big ability К-26 to induce tumor apoptosis. Higher level of an expression of gene MDR2 in spleen cages (55 …

Diagnosis Of Medicinal Plant Physalis Alkekengi, Z.A. Kadirova, Sh.S. Tashmukhamedova, R.X. Madjidova

Problems and Perspectives in Pharmaceutics and Drug Discovery

In this research, the diagnosis of the medicinal plant Physalis alkekengi has been developed by the double diffusion method. The tobacco mosaic virus strain of tomato was purified from the Physalis al-kekengi plant by biospecific chromatography. In this case,polyamide granules based immunosorbent with covalently immobilized antibodieswas used. The optimal condition for the sorption and desorption of the virus on the immunosorbent has been established. The serological activity of the virus, which affects on biological activity of the plant, has been studied.

Studying Of Optimum Conditions Of Sertraline Extract From Water Solutions, F.S. Jalilov, M.A. Tadjiev, L.T. Pulatova

Problems and Perspectives in Pharmaceutics and Drug Discovery

The results of studying of sertraline extraction from water are given in these article solutions. At excre-tion sertraline from water solution are studied such factors of extractions defining completeness, as the nature of organic solvent and an indicator рН solution are studied. At extraction sertraline with the use as an extragent chloroform at рН environments 9,18 the exit of sertraline was from water solution 91,9%.

Determination The Identity Of Drugs Having Toxicologycal Property, X.Q. Olimov, M.A Тojiev

Problems and Perspectives in Pharmaceutics and Drug Discovery

Preparations metoprolol and atenolol are widely applied in the medical practice, for the treatment of the first stage of stenocardia, prevent re-infarction, in arterial hypertension, tachycardia, as well as for the treatment of migrainePreparations are less studied in the chemical-toxicological relation. There is no available methods for allocating from biological fluids (blood, urine, wash the stomach) as well as from biological objects (liver, kidneys).Developed a technique identifying metoprolol and atenolol TLC: solvent system is ethanol-30% acetic acid-benzole (3: 1: 1). Initially for determining rising of level substances is defected in the UV light after that is defined by Dragendorff reagents …

Isolation And Determination Of Mebendazole From Biological Material By Hplc Method, Z.U. Usmonaliyeva, M.A. Tadjiev, R. Rashitov

Problems and Perspectives in Pharmaceutics and Drug Discovery

The conditions for detection and determination of mebendazole were developed by HPLC. The re-zults showad, thet retention time of the mebendazole was 3.35 minutes. For quantitative determination of mebendazole, was constructed a calibration curve, the linearity of which was 10.0-50.0 mkg. The detec-tion limit for mebendazole is 0.5 mkg / ml. The possibility of using this method in the quantitative analysis of mebendazole isolated from a biological object. At the same time, isolated from the biological object in amount of 54.62%.

Application Of Digital Technologies On Metabolomic Profiling And Standardization Of Medicinal Plants, G.T. Mavlnov, Kh.O. Tursunov, O.V. Lee

Problems and Perspectives in Pharmaceutics and Drug Discovery

Using silica plate based 2D-HPTLC in combination with digital image processing softwares (such as Adobe Photoshop, Quantity One and Melanie) it is shown possibility of the metabolic profiling of medici-nal plants and standardization of their extract on example of chamomile’s flowers phenolics and polar lip-ids extract.

E-Co-Affectivity Beyond The Anthropocene: Rethinking The Role Of Soil To Imagine A New 'Us', Marjolein Oele

Philosophy

Following Isabelle Stengers’ call that the anthropocene should make us feel and think differently, this paper focuses on the human task to shift its affective response. Since Stengers calls for a new “us” that seeks to participate in an entanglement, I propose to explore the material and ontogenetic functions of soil, and specifically soil pores, in reimagining a new form of e-co-affectivity. A new e-co-affective response would emphasize the usually hidden fluidity and diachronic time of pores, and, in doing so, cultivate an epistemic and aesthetic sensitivity, deceleration, and percolation.

Whitworth University Catalog 2018-2019, Whitworth University

Whitworth Catalog

No abstract provided.

Social Justice Disaster Relief, Counseling, And Advocacy: The Case Of The Northern California Wildfires, Daniela Domínguez

Psychology

Using our professional experiences with natural disaster relief, as well as existing theory, the authors introduce an equity-oriented framework— Social Justice Disaster Relief, Counseling, and Advocacy. We then present the case of the 2017 Northern California wildfires using responses from 259 individuals who were living in the region of the Northern California wildfires—the most destructive fires in California state history. We collected qualitative and demographic data on each participant three months after the fires ended. Qualitative data included detailed written reflections to a prompt from each participant in response to an online questionnaire. A thematic analysis using open, axial, and …

Can Genomic Variation Explain The Extinction Of The Passenger Pigeon?, Chih-Ming Hung, R. M. Zink, Shou-Hsien Li

School of Natural Resources: Faculty Publications

No abstract provided.

Hybrid Speciation In Birds, With Special Reference To Darwin's Finches, G. E. Hill, R. M. Zink

School of Natural Resources: Faculty Publications

No abstract provided.

Gene Flow From Single And Stacked Herbicide-Resistant Rice (Oryza Sativa): Modeling Occurrence Of Multiple Herbicide-Resistant Weedy Rice, Joseph Dauer, Andrew Hulting, Dale Carlson, Luke Mankin, John Harden, Carol Mallory-Smith

School of Natural Resources: Faculty Publications

Background: Provisia™ rice (PV), a non-genetically engineered (GE) quizalofop-resistant rice, will provide growers with an additional option for weed management to use in conjunction with Clearfield® rice (CL) production. Modeling compared the impact of stacking resistance traits versus single traits in rice on introgression of the resistance trait to weedy rice (also called red rice). Common weed management practices were applied to 2-, 3- and 4-year crop rotations, and resistant and multiple-resistant weedy rice seeds, seedlings and mature plants were tracked for 15 years.

Results: Two-year crop rotations resulted in resistant weedy rice after 2 years with abundant populations (exceeding …

Dominant Plant Species Shape Soil Bacterial Community In Semiarid Sandy Land Of Northern China, Shaokun Wang, Xiaoan Zuo, Xueyong Zhao, Tala Awada, Yongqing Luo, Yuqiang Li, Hao Qu

School of Natural Resources: Faculty Publications

Plant species affect soil bacterial diversity and compositions. However, little is known about the role of dominant plant species in shaping the soil bacterial community during the restoration of sandy grasslands in Horqin Sandy Land, northern China. We established a mesocosm pots experiment to investigate short-term responses of soil bacterial diversity and composition, and the related soil properties in degraded soils without vegetation (bare sand as the control, CK) to restoration with five plant species that dominate across restoration stages: Agriophyllum squarrosum (AS), Artemisia halodendron (AH), Setaria viridis (SV), Chenopodium acuminatum (CA), and Corispermum macrocarpum (CM). We used redundancy analysis …

Urban Stream Microbial Communities Show Resistance To Pharmaceutical Exposure, E. J. Rosi, H. A. Bechtold, D. D. Snow, M. Rojas, A. J. Reisinger, J. J. Kelly

School of Natural Resources: Faculty Publications

Residues of pharmaceuticals are increasingly detected in surface waters throughout the world. In four streams in Baltimore, Maryland, USA, we detected analgesics, stimulants, antihistamines, and antibiotics using passive organic samplers. We exposed biofilm communities in these streams to the common drugs caffeine, cimetidine, ciprofloxacin, and diphenhydramine. Respiration rates in the least urban stream were suppressed when exposed to these drugs, but biofilm functioning in the most urban stream was resistant to drug exposure. Exposure to the antibiotic ciprofloxacin altered bacterial community composition at all sites, with the greatest change occurring in the most urban stream. These results indicated that continuous …

Rainfall Simulation Experiments In The Southwestern Usa Using The Walnut Gulch Rainfall Simulator, Viktor O. Polyakov, Jeffry Stone, Chandra Holifield Collins, Mark A. Nearing, Ginger Paige, Jared Buono, Rae-Landa Gomez-Pond

School of Natural Resources: Faculty Publications

This dataset contains hydrological, erosion, vegetation, ground cover, and other supplementary information from 272 rainfall simulation experiments conducted on 23 semiarid rangeland locations in Arizona and Nevada between 2002 and 2013. On 30% of the plots, simulations were conducted up to five times during the decade of study. The rainfall was generated using the Walnut Gulch Rainfall Simulator on 2m by 6m plots. Simulation sites included brush and grassland areas with various degrees of disturbance by grazing, wildfire, or brush removal. This dataset advances our understanding of basic hydrological and biological processes that drive soil erosion on arid rangelands. It …

Understanding Deer, Bear, And Forest Trends In The North Georgia Mountains: The Value Of Long-Term Data, Andrew R. Little, Gino J. D'Angelo, Charlie H. Killmaster, Kristina L. Johannsen, Karl V. Miller

School of Natural Resources: Faculty Publications

Most state wildlife agencies collect harvest data to inform management decisions. However, these data are typically considered across relatively short time periods and are rarely revisited. We present a case study using historical records to investigate potential agents (i.e., harvest, predation, and forest change) influencing the declining white-tailed deer (Odocoileus virginianus) population in the north Georgia mountains. We used long-term black bear (Ursus americanus) and deer harvest data, and indices of forest stand conditions from 1979–2015 on eight Wildlife Management Areas (WMAs) in the north Georgia mountains. During 1979–2015, harvest of male and female deer declined by 85% and 97%, …

Reproductive Ecology Of Interior Least Tern And Piping Plover In Relation To Platte River Hydrology And Sandbar Dynamics, Jason S. Alexander, Joel G. Jorgensen, Mary B. Brown

School of Natural Resources: Faculty Publications

Historical and contemporary use of large, economically important rivers by threatened and/or endangered species in the United States is a subject of great interest to a wide range of stakeholders. In a recent study of the Platte River in Nebraska, Farnsworth et al. (2017) (hereinafter referred to as “the authors” or “Farnsworth et al.”) used distributions of nest initiation dates taken mostly from human-created, off-channel habitats and a model of emergent sandbar habitat to evaluate the hypothesis that least terns (Sternula antillarum) and piping plovers (Charadrius melodus) are physiologically adapted to initiate nests concurrent with the …